[Hub]/) : Traits : Nervous feelings :

chr10:103,550,604-105,647,095

Best TWAS P=5.45e-10 · Best GWAS P=1.87e-10 conditioned to 0.0104

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta NT5C2 0.08 0.02 lasso 7 0.01 1.2e-01 4.3 5.7 9.2e-09 -0.76 0.06 0.82 FALSE
2 GTEx Artery Tibial NT5C2 0.06 0.04 lasso 9 0.02 1.5e-02 -5.1 5.5 5.0e-08 -0.75 0.06 0.83 FALSE
3 GTEx Breast Mammary Tissue (Female) CYP17A1-AS1 0.14 0.01 lasso 11 0.00 4.7e-01 -5.0 -5.3 1.0e-07 0.54 0.07 0.15 FALSE
4 GTEx Liver ACTR1A 0.15 0.00 lasso 10 0.00 4.6e-01 1.5 5.3 1.4e-07 -0.58 0.04 0.55 FALSE
5 ROSMAP Brain Pre-frontal Cortex CNNM2 0.11 0.08 lasso 3 0.07 2.2e-09 -5.3 -5.3 8.9e-08 0.37 0.70 0.30 FALSE
6 The Cancer Genome Atlas Bladder Urothelial Carcinoma AS3MT 0.06 0.09 enet 6 0.07 1.3e-06 -5.9 6.2 5.4e-10 -0.76 0.05 0.94 TRUE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AS3MT 0.04 0.05 enet 3 0.04 8.6e-06 -5.9 5.9 4.6e-09 -0.80 0.04 0.96 FALSE
8 The Cancer Genome Atlas Rectum Adenocarcinoma C10orf32 0.17 0.14 blup 52 0.14 3.2e-04 -5.1 5.5 4.8e-08 -0.81 0.04 0.60 FALSE
9 The Cancer Genome Atlas Thyroid Carcinoma AS3MT 0.23 0.18 lasso 3 0.18 1.8e-17 -5.9 5.6 2.8e-08 -0.80 0.05 0.95 FALSE
10 The Cancer Genome Atlas Thyroid Carcinoma CYP17A1 0.04 0.02 lasso 1 0.02 3.9e-03 -5.2 5.2 1.7e-07 -0.74 0.02 0.72 FALSE