Best TWAS P=5.45e-10 · Best GWAS P=1.87e-10 conditioned to 0.0104
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | NT5C2 | 0.08 | 0.02 | lasso | 7 | 0.01 | 1.2e-01 | 4.3 | 5.7 | 9.2e-09 | -0.76 | 0.06 | 0.82 | FALSE |
| 2 | GTEx | Artery Tibial | NT5C2 | 0.06 | 0.04 | lasso | 9 | 0.02 | 1.5e-02 | -5.1 | 5.5 | 5.0e-08 | -0.75 | 0.06 | 0.83 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CYP17A1-AS1 | 0.14 | 0.01 | lasso | 11 | 0.00 | 4.7e-01 | -5.0 | -5.3 | 1.0e-07 | 0.54 | 0.07 | 0.15 | FALSE |
| 4 | GTEx | Liver | ACTR1A | 0.15 | 0.00 | lasso | 10 | 0.00 | 4.6e-01 | 1.5 | 5.3 | 1.4e-07 | -0.58 | 0.04 | 0.55 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CNNM2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.2e-09 | -5.3 | -5.3 | 8.9e-08 | 0.37 | 0.70 | 0.30 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AS3MT | 0.06 | 0.09 | enet | 6 | 0.07 | 1.3e-06 | -5.9 | 6.2 | 5.4e-10 | -0.76 | 0.05 | 0.94 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AS3MT | 0.04 | 0.05 | enet | 3 | 0.04 | 8.6e-06 | -5.9 | 5.9 | 4.6e-09 | -0.80 | 0.04 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | C10orf32 | 0.17 | 0.14 | blup | 52 | 0.14 | 3.2e-04 | -5.1 | 5.5 | 4.8e-08 | -0.81 | 0.04 | 0.60 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | AS3MT | 0.23 | 0.18 | lasso | 3 | 0.18 | 1.8e-17 | -5.9 | 5.6 | 2.8e-08 | -0.80 | 0.05 | 0.95 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | CYP17A1 | 0.04 | 0.02 | lasso | 1 | 0.02 | 3.9e-03 | -5.2 | 5.2 | 1.7e-07 | -0.74 | 0.02 | 0.72 | FALSE |