Hub : Traits :

Nervous feelings

738 significantly associated models · 121 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	148450412	149022674	1	1	2.6e-08	5.5e-07	0.5440	98	ORC4L
2	3	49598064	51234774	6	1	9.6e-08	7.8e-08	1.0000	100	U73166.2
3	3	51616334	53778875	11	1	1.2e-08	8.9e-08	0.5710	99	ITIH4
4	3	84317575	86808226	1	1	6.4e-17	3.1e-17	0.1000	96	CADM2
5	3	135273949	137261517	5	1	1.0e-10	5.1e-10	0.5410	99	RP11-85F14.5
6	5	92808753	94615316	1	1	2.4e-09	2.4e-08	1.0000	100	KIAA0825
7	6	25296606	26689223	1	1	9.8e-08	1.1e-06	0.0061	68	U91328.19
8	6	89108830	90520848	1	1	2.1e-07	1.6e-05	0.2340	92	SRSF12
9	7	6502367	7988091	1	1	7.0e-08	1.8e-08	0.0542	88	C1GALT1
10	8	8092025	13120332	34	1	7.6e-20	1.7e-16	0.0251	93	AF131215.2
11	10	103550604	105647095	7	1	5.4e-10	1.9e-10	0.0104	84	AS3MT
12	11	46499874	48028343	2	2	6.7e-09	2.0e-07	0.6930	99	MADD PACSIN3
13	14	74424938	76089054	4	1	5.8e-11	2.4e-09	0.5020	99	AREL1
14	16	28825605	31860399	17	2	4.5e-11	5.5e-10	0.4220	98	INO80E KAT8
15	17	1517914	2939981	3	1	5.0e-10	5.5e-07	0.0055	69	SRR
16	17	4488884	6031861	2	1	4.2e-08	4.4e-08	1.0000	100	RPAIN
17	17	42607368	45796313	20	1	2.3e-11	1.3e-10	1.0000	100	LRRC37A4P
18	20	32594714	34225302	3	2	6.5e-08	1.5e-08	0.1320	93	GSS TP53INP2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder (2018)	3.1	2	0	0.0	0.00	1.0e+00	ITIH4 TP53INP2
Bipolar Disorder or Schizophrenia	4.5	3	3	6.7	0.00	1.0e+00	AS3MT INO80E ITIH4
Depressed Affect (Nagel 2018)	6.5	5	3	6.7	0.97	7.1e-03	AREL1 LRRC37A4P MADD ORC4L RP11-85F14.5
Depression (Nagel 2018)	5.0	4	1	2.2	-0.01	9.9e-01	LRRC37A4P MADD RP11-85F14.5 U73166.2
Intelligence (Savage-Jansen 2018)	2.2	3	1	2.2	0.00	1.0e+00	ITIH4 LRRC37A4P RP11-85F14.5
Neuroticism (Nagel 2018)	12.3	14	7	15.6	0.95	2.5e-07	AREL1 AS3MT CADM2 GSS ITIH4 KAT8 LRRC37A4P MADD ORC4L RP11-85F14.5 SRR SRSF12 TP53INP2 U73166.2
Schizophrenia (2018)	4.7	5	3	6.7	0.98	4.6e-03	AS3MT INO80E ITIH4 RP11-85F14.5 U91328.19
Worry (Nagel 2018)	16.3	17	11	24.4	0.99	9.6e-14	AREL1 AS3MT CADM2 GSS INO80E ITIH4 KAT8 LRRC37A4P MADD ORC4L PACSIN3 RP11-85F14.5 RPAIN SRR SRSF12 TP53INP2 U73166.2
Alzheimer’s Disease (in mother)	2.3	1	0	0.0	0.00	1.0e+00	KAT8
Alzheimer’s Disease (including proxy)	3.5	2	1	2.2	0.00	1.0e+00	KAT8 MADD
Verbal and Numeric Reasoning (VNR)	2.5	2	1	2.2	0.00	1.0e+00	ITIH4 LRRC37A4P
Breast Cancer	2.4	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Ovarian Cancer	2.7	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Bipolar Disorder (2011)	5.0	1	1	2.2	0.00	1.0e+00	ITIH4
Body Mass Index (BMI) (2010)	4.0	2	0	0.0	0.00	1.0e+00	MADD RPAIN
Coronary Artery Disease (CAD)	2.0	1	0	0.0	0.00	1.0e+00	AS3MT
Mean Putamen Volume	2.4	1	0	0.0	0.00	1.0e+00	TP53INP2
Fasting Glucose	3.5	2	1	2.2	0.00	1.0e+00	MADD PACSIN3
Lupus	1.8	1	0	0.0	0.00	1.0e+00	AF131215.2
Neuroticism (2016)	9.0	5	2	4.4	1.00	1.2e-04	AF131215.2 AREL1 LRRC37A4P MADD U73166.2
Primary Biliary Cirrhosis	1.8	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Schizophrenia (2014)	4.9	4	3	6.7	0.97	2.7e-02	AS3MT INO80E ITIH4 RP11-85F14.5
Triglycerides	3.3	2	1	2.2	0.00	1.0e+00	KAT8 TP53INP2
Blood Eosinophil Count	2.0	6	3	6.7	-0.32	5.3e-01	INO80E ITIH4 KAT8 LRRC37A4P ORC4L SRSF12
Blood Platelet Count	1.4	9	6	13.3	-0.60	9.0e-02	AREL1 AS3MT ITIH4 LRRC37A4P MADD PACSIN3 RP11-85F14.5 RPAIN U73166.2
Blood Red Count	4.3	5	4	8.9	0.90	3.9e-02	AS3MT INO80E ITIH4 KAT8 LRRC37A4P
Blood White Count	1.7	4	3	6.7	-0.69	3.1e-01	LRRC37A4P MADD RP11-85F14.5 RPAIN
Heel T-Score	2.1	6	5	11.1	0.02	9.7e-01	AREL1 INO80E KAT8 LRRC37A4P MADD PACSIN3
BMI	6.0	10	9	20.0	-0.84	2.3e-03	AS3MT CADM2 INO80E ITIH4 KAT8 MADD RPAIN SRR SRSF12 TP53INP2
Height	2.2	11	8	17.8	-0.35	2.9e-01	AREL1 AS3MT GSS INO80E ITIH4 KAT8 LRRC37A4P MADD ORC4L TP53INP2 U73166.2
Waist Hip Ratio (WHR)	3.0	4	4	8.9	-0.21	7.9e-01	ITIH4 LRRC37A4P RP11-85F14.5 U73166.2
Systolic Blood Pressure	5.0	7	6	13.3	0.70	8.1e-02	AREL1 AS3MT CADM2 LRRC37A4P MADD ORC4L SRR
Smoking Status	5.2	4	3	6.7	-0.98	2.1e-02	AS3MT CADM2 ITIH4 SRR
Allergy or Eczema	1.4	1	0	0.0	0.00	1.0e+00	SRR
Cardiovascular Disease	2.6	3	1	2.2	0.00	1.0e+00	AS3MT KAT8 RP11-85F14.5
Lung FEV1/FVC ratio	1.8	5	1	2.2	-0.64	2.5e-01	AREL1 C1GALT1 INO80E ITIH4 LRRC37A4P
Lung FVC	3.8	4	3	6.7	-0.59	4.1e-01	KAT8 LRRC37A4P TP53INP2 U73166.2
Neuroticism	11.9	13	8	17.8	0.96	2.8e-07	AREL1 AS3MT CADM2 GSS ITIH4 KAT8 LRRC37A4P MADD ORC4L RP11-85F14.5 SRSF12 TP53INP2 U73166.2
Chronotype (morning person)	2.2	1	1	2.2	0.00	1.0e+00	U73166.2
Hair Pigment	11.0	3	2	4.4	0.00	1.0e+00	GSS LRRC37A4P TP53INP2
Tanning	22.0	5	3	6.7	-0.65	2.4e-01	AREL1 CADM2 GSS ITIH4 TP53INP2
Hand grip strength (left)	4.7	7	4	8.9	-0.43	3.4e-01	AREL1 AS3MT CADM2 INO80E KAT8 LRRC37A4P MADD
Number of treatments/medications taken	2.8	1	1	2.2	0.00	1.0e+00	AREL1
Sensitivity / hurt feelings	7.3	4	2	4.4	0.93	7.5e-02	AF131215.2 LRRC37A4P ORC4L RP11-85F14.5
Frequency of depressed mood in last 2 weeks	5.4	4	0	0.0	-0.78	2.2e-01	LRRC37A4P MADD RP11-85F14.5 U73166.2
Hearing difficulty/problems: Yes	2.3	1	0	0.0	0.00	1.0e+00	KIAA0825
Relative age of first facial hair	4.2	2	1	2.2	0.00	1.0e+00	LRRC37A4P TP53INP2
Systolic blood pressure, automated reading	4.6	6	4	8.9	0.29	5.8e-01	AF131215.2 AREL1 AS3MT LRRC37A4P MADD SRR
Vitamin and mineral supplements	2.5	1	0	0.0	0.00	1.0e+00	U91328.19
Diabetes (father)	2.0	1	0	0.0	0.00	1.0e+00	INO80E
Impedance of leg (right)	5.3	12	9	20.0	0.84	6.5e-04	AF131215.2 AREL1 AS3MT CADM2 INO80E ITIH4 KAT8 LRRC37A4P MADD PACSIN3 TP53INP2 U73166.2
Leg fat-free mass (left)	5.7	10	8	17.8	-0.94	4.5e-05	AF131215.2 AS3MT CADM2 INO80E KAT8 PACSIN3 RPAIN SRSF12 TP53INP2 U91328.19
Trunk fat percentage	4.9	8	5	11.1	-0.68	6.1e-02	AREL1 INO80E KAT8 LRRC37A4P MADD RPAIN SRR U91328.19
Hand grip strength (right)	3.5	4	2	4.4	-0.61	3.9e-01	CADM2 INO80E LRRC37A4P MADD
Current tobacco smoking	2.3	1	0	0.0	0.00	1.0e+00	AS3MT
Maternal smoking around birth	1.8	1	0	0.0	0.00	1.0e+00	AS3MT
Fed-up feelings	5.5	6	4	8.9	0.98	3.5e-04	AF131215.2 AREL1 LRRC37A4P MADD ORC4L RP11-85F14.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	2	0	0.0	0.00	1.0e+00	RP11-85F14.5 U73166.2
Relative age voice broke	3.5	2	1	2.2	0.00	1.0e+00	LRRC37A4P TP53INP2
Taking other prescription medications	2.7	1	1	2.2	0.00	1.0e+00	AREL1
Age when periods started (menarche)	3.3	3	1	2.2	0.00	1.0e+00	INO80E LRRC37A4P MADD
Heel bone mineral density (BMD) T-score, automated (left)	3.5	2	1	2.2	0.00	1.0e+00	AF131215.2 U91328.19
High blood pressure	4.1	3	3	6.7	0.00	1.0e+00	AF131215.2 KAT8 MADD
Hayfever, allergic rhinitis or eczema	2.4	2	1	2.2	0.00	1.0e+00	SRR U91328.19
Medication: Levothyroxine sodium	2.0	1	1	2.2	0.00	1.0e+00	U91328.19
Sitting height	3.2	6	5	11.1	-0.36	4.8e-01	INO80E ITIH4 LRRC37A4P MADD TP53INP2 U91328.19
Body mass index (BMI)	6.7	11	9	20.0	-0.87	5.4e-04	AF131215.2 AS3MT CADM2 INO80E ITIH4 KAT8 MADD RPAIN SRR SRSF12 U91328.19
Impedance of leg (left)	5.3	12	9	20.0	0.84	6.6e-04	AF131215.2 AREL1 AS3MT CADM2 INO80E ITIH4 LRRC37A4P MADD PACSIN3 SRSF12 TP53INP2 U73166.2
Leg predicted mass (left)	5.7	10	8	17.8	-0.94	4.3e-05	AF131215.2 AS3MT CADM2 INO80E KAT8 PACSIN3 RPAIN SRSF12 TP53INP2 U91328.19
Trunk fat mass	5.8	10	6	13.3	-0.81	4.7e-03	AS3MT CADM2 INO80E KAT8 LRRC37A4P MADD RPAIN SRR SRSF12 U91328.19
Waist circumference	6.0	8	5	11.1	-0.95	3.7e-04	AS3MT CADM2 INO80E KAT8 MADD RPAIN SRSF12 U91328.19
Number of incorrect matches in round	3.7	3	0	0.0	0.00	1.0e+00	AS3MT INO80E KAT8
Past tobacco smoking	5.2	3	2	4.4	0.00	1.0e+00	AS3MT CADM2 SRR
Alcohol usually taken with meals	2.4	1	0	0.0	0.00	1.0e+00	SRR
Frequency of tenseness / restlessness in last 2 weeks	6.6	3	1	2.2	0.00	1.0e+00	LRRC37A4P MADD RP11-85F14.5
Hearing difficulty/problems with background noise	3.9	3	0	0.0	0.00	1.0e+00	KIAA0825 LRRC37A4P U91328.19
Hair/balding pattern: Pattern 2	2.5	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Forced vital capacity (FVC)	2.8	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Heel bone mineral density (BMD) T-score, automated (right)	3.4	2	1	2.2	0.00	1.0e+00	AF131215.2 U91328.19
Ever unenthusiastic/disinterested for a whole week	3.2	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Allergy	2.0	2	1	2.2	0.00	1.0e+00	SRR U91328.19
Hayfever/allergic rhinitis (self-reported)	2.1	1	0	0.0	0.00	1.0e+00	U91328.19
Neuroticism score	13.3	8	8	17.8	0.99	1.3e-06	AF131215.2 AREL1 LRRC37A4P MADD ORC4L RP11-85F14.5 TP53INP2 U73166.2
Weight	6.8	10	9	20.0	-0.93	9.4e-05	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRSF12 TP53INP2 U91328.19
Impedance of arm (right)	5.4	9	8	17.8	0.77	1.6e-02	AF131215.2 CADM2 GSS INO80E ITIH4 LRRC37A4P RPAIN TP53INP2 U73166.2
Arm fat percentage (right)	5.4	9	6	13.3	-0.80	9.1e-03	AF131215.2 AS3MT INO80E KAT8 MADD RPAIN SRR SRSF12 U91328.19
Trunk fat-free mass	4.9	9	7	15.6	-0.91	5.5e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Hip circumference	6.8	10	8	17.8	-0.91	2.5e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRSF12 TP53INP2 U91328.19
Worrier / anxious feelings	14.0	12	8	17.8	0.98	8.8e-09	AF131215.2 AREL1 AS3MT C1GALT1 CADM2 INO80E ITIH4 KAT8 LRRC37A4P ORC4L RP11-85F14.5 U73166.2
Frequency of tiredness / lethargy in last 2 weeks	3.3	1	0	0.0	0.00	1.0e+00	ORC4L
Hair/balding pattern: Pattern 3	4.1	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Number of live births	2.4	2	0	0.0	0.00	1.0e+00	CADM2 LRRC37A4P
Forced expiratory volume in 1-second (FEV1)	3.3	3	1	2.2	0.00	1.0e+00	AF131215.2 KAT8 LRRC37A4P
Qualifications: A levels/AS levels or equivalent	1.9	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Mouth/teeth dental problems: Dentures	4.1	3	1	2.2	0.00	1.0e+00	AF131215.2 TP53INP2 U91328.19
Medication: Ibuprofen (e.g. Nurofen)	2.4	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	2	2	4.4	0.00	1.0e+00	KAT8 LRRC37A4P
Impedance of arm (left)	5.4	10	7	15.6	0.77	9.9e-03	AF131215.2 AS3MT CADM2 GSS INO80E ITIH4 LRRC37A4P RPAIN TP53INP2 U73166.2
Arm fat mass (right)	6.6	11	7	15.6	-0.83	1.6e-03	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRR SRSF12 TP53INP2 U91328.19
Trunk predicted mass	4.9	9	6	13.3	-0.91	5.8e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Standing height	2.3	8	6	13.3	-0.39	3.3e-01	AF131215.2 AS3MT INO80E ITIH4 LRRC37A4P MADD TP53INP2 U91328.19
Tense / 'highly strung'	10.5	11	1	2.2	0.99	7.0e-09	AF131215.2 AREL1 CADM2 GSS INO80E KAT8 ORC4L RP11-85F14.5 RPAIN TP53INP2 U73166.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	1	0	0.0	0.00	1.0e+00	AREL1
Hair/balding pattern: Pattern 4	6.1	2	2	4.4	0.00	1.0e+00	LRRC37A4P SRR
Birth weight of first child	1.8	1	0	0.0	0.00	1.0e+00	AS3MT
Peak expiratory flow (PEF)	3.1	2	1	2.2	0.00	1.0e+00	AF131215.2 LRRC37A4P
Medication: Paracetamol	3.5	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Headache pain in last month	4.1	2	1	2.2	0.00	1.0e+00	ITIH4 LRRC37A4P
Hypothyroidism/myxoedema (self-reported)	1.8	1	1	2.2	0.00	1.0e+00	U91328.19
Birth weight	1.8	2	0	0.0	0.00	1.0e+00	AS3MT SRR
High blood pressure (siblings)	2.0	1	0	0.0	0.00	1.0e+00	KAT8
Forced vital capacity (FVC), Best measure	2.7	2	1	2.2	0.00	1.0e+00	KAT8 LRRC37A4P
Body fat percentage	5.0	7	5	11.1	-0.71	7.5e-02	AREL1 INO80E KAT8 MADD RPAIN SRR U91328.19
Leg fat percentage (right)	4.5	8	6	13.3	-0.67	7.0e-02	AF131215.2 AREL1 CADM2 INO80E KAT8 MADD RPAIN U91328.19
Arm fat-free mass (right)	5.9	9	8	17.8	-0.93	2.2e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Comparative body size at age 10	6.3	9	5	11.1	-0.27	4.8e-01	AF131215.2 CADM2 KAT8 MADD PACSIN3 SRR TP53INP2 U73166.2 U91328.19
Worry too long after embarrassment	7.2	5	2	4.4	0.99	4.5e-04	AF131215.2 LRRC37A4P RP11-85F14.5 SRR TP53INP2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	1	0	0.0	0.00	1.0e+00	U91328.19
Number of children fathered	3.0	1	1	2.2	0.00	1.0e+00	CADM2
Age at first live birth	1.8	1	0	0.0	0.00	1.0e+00	AF131215.2
Qualifications: College or University degree	2.2	2	1	2.2	0.00	1.0e+00	CADM2 LRRC37A4P
Medication for pain relief, constipation, heartburn	2.8	2	1	2.2	0.00	1.0e+00	AREL1 LRRC37A4P
Medication: Ibuprofen	1.8	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Whole body fat mass	6.1	11	7	15.6	-0.81	2.6e-03	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRR SRSF12 TP53INP2 U91328.19
Leg fat mass (right)	6.5	9	8	17.8	-0.94	1.5e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRSF12 U91328.19
Arm predicted mass (right)	5.9	9	8	17.8	-0.93	2.2e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Pulse rate, automated reading	1.7	1	0	0.0	0.00	1.0e+00	ORC4L
Alcohol intake frequency.	3.9	5	4	8.9	-0.26	6.7e-01	CADM2 INO80E KAT8 LRRC37A4P MADD
Comparative height size at age 10	2.1	4	4	8.9	-0.67	3.3e-01	INO80E ITIH4 LRRC37A4P TP53INP2
Number of full sisters	1.8	1	0	0.0	0.00	1.0e+00	CADM2
Suffer from 'nerves'	10.9	8	3	6.7	0.97	3.9e-05	AF131215.2 AREL1 AS3MT CADM2 INO80E KAT8 KIAA0825 MADD
Overall health rating	2.4	1	0	0.0	0.00	1.0e+00	KAT8
Age at last live birth	2.0	1	0	0.0	0.00	1.0e+00	AF131215.2
Supplements: Vitamin C	2.2	1	0	0.0	0.00	1.0e+00	U91328.19
Hypertension (Self-reported)	3.9	3	2	4.4	0.00	1.0e+00	AF131215.2 KAT8 MADD
Smoking status: Previous	4.2	1	1	2.2	0.00	1.0e+00	CADM2
Forced expiratory volume in 1-second (FEV1), predicted	2.3	1	1	2.2	0.00	1.0e+00	TP53INP2
Whole body fat-free mass	5.4	9	8	17.8	-0.93	2.9e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Leg fat-free mass (right)	5.6	10	8	17.8	-0.94	4.8e-05	AF131215.2 AS3MT CADM2 INO80E KAT8 PACSIN3 RPAIN SRSF12 TP53INP2 U91328.19
Arm fat percentage (left)	5.5	9	6	13.3	-0.80	9.1e-03	AF131215.2 AS3MT INO80E KAT8 MADD RPAIN SRR SRSF12 U91328.19
Handedness (chirality/laterality): Left-handed	1.7	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Mood swings	6.6	4	3	6.7	0.94	5.7e-02	AF131215.2 AREL1 LRRC37A4P MADD
Loneliness, isolation	4.7	4	1	2.2	0.98	2.1e-02	LRRC37A4P MADD ORC4L RP11-85F14.5
Mouth/teeth dental problems: Mouth ulcers	2.1	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Medication for cholesterol	2.5	1	0	0.0	0.00	1.0e+00	KAT8
Smoking status: Current	2.7	1	0	0.0	0.00	1.0e+00	AS3MT
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.9	4	3	6.7	-0.07	9.3e-01	AF131215.2 KAT8 LRRC37A4P U91328.19
Whole body water mass	5.4	9	8	17.8	-0.93	3.0e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Leg predicted mass (right)	5.6	10	7	15.6	-0.94	5.3e-05	AF131215.2 AS3MT CADM2 INO80E KAT8 PACSIN3 RPAIN SRSF12 TP53INP2 U91328.19
Arm fat mass (left)	6.7	11	8	17.8	-0.84	1.3e-03	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRR SRSF12 TP53INP2 U91328.19
Number of self-reported non-cancer illnesses	2.1	1	0	0.0	0.00	1.0e+00	AREL1
Average weekly champagne plus white wine intake	2.4	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Miserableness	6.3	5	3	6.7	0.94	1.8e-02	AF131215.2 LRRC37A4P MADD ORC4L RP11-85F14.5
Guilty feelings	6.2	4	3	6.7	0.99	6.3e-03	AF131215.2 AREL1 LRRC37A4P MADD
Medication: Blood pressure	3.9	4	2	4.4	-0.86	1.4e-01	AF131215.2 C1GALT1 KAT8 LRRC37A4P
Medication: Bendroflumethiazide	3.5	2	0	0.0	0.00	1.0e+00	AF131215.2 KAT8
Medication: Paracetamol	3.4	1	1	2.2	0.00	1.0e+00	LRRC37A4P
Illnesses of father: High blood pressure	2.2	1	0	0.0	0.00	1.0e+00	MADD
Ever smoked	4.3	3	1	2.2	0.00	1.0e+00	AS3MT CADM2 SRR
Basal metabolic rate	5.8	9	8	17.8	-0.93	2.3e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Leg fat percentage (left)	4.8	8	6	13.3	-0.68	6.6e-02	AF131215.2 AREL1 CADM2 INO80E KAT8 MADD RPAIN U91328.19
Arm fat-free mass (left)	5.9	9	8	17.8	-0.94	2.1e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19
Irritability	6.5	5	3	6.7	0.98	2.9e-03	AF131215.2 AREL1 LRRC37A4P ORC4L TP53INP2
Risk taking	5.3	3	1	2.2	0.00	1.0e+00	AF131215.2 CADM2 RP11-85F14.5
Diastolic blood pressure, automated reading	3.1	4	3	6.7	0.08	9.2e-01	AF131215.2 KAT8 MADD SRR
Vascular/heart problems diagnosed by doctor	3.7	3	2	4.4	0.00	1.0e+00	AF131215.2 KAT8 MADD
Pain experienced in last month	2.0	1	0	0.0	0.00	1.0e+00	LRRC37A4P
Basal cell carcinoma (self-reported)	2.8	2	1	2.2	0.00	1.0e+00	GSS TP53INP2
Impedance of whole body	5.9	11	8	17.8	0.79	4.2e-03	AF131215.2 AREL1 AS3MT CADM2 GSS INO80E ITIH4 KAT8 LRRC37A4P TP53INP2 U73166.2
Leg fat mass (left)	6.7	9	8	17.8	-0.94	1.8e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 MADD RPAIN SRSF12 U91328.19
Arm predicted mass (left)	6.0	9	8	17.8	-0.94	1.9e-04	AF131215.2 AS3MT CADM2 INO80E KAT8 RPAIN SRSF12 TP53INP2 U91328.19

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	15	0.43	1.8
GTEx	Adipose Visceral Omentum	12	0.59	2.0
GTEx	Adrenal Gland	9	0.62	1.9
GTEx	Artery Aorta	19	0.64	2.0
GTEx	Artery Coronary	12	1.01	2.1
GTEx	Artery Tibial	17	0.45	1.9
GTEx	Brain Caudate basal ganglia	6	0.65	2.0
GTEx	Brain Cerebellar Hemisphere	9	0.60	2.0
GTEx	Brain Cerebellum	8	0.40	2.0
GTEx	Brain Cortex	7	0.68	2.1
GTEx	Brain Frontal Cortex BA9	6	0.65	2.2
GTEx	Brain Hippocampus	5	0.95	2.2
GTEx	Brain Hypothalamus	4	0.68	1.9
GTEx	Brain Nucleus accumbens basal ganglia	8	0.92	1.9
GTEx	Brain Putamen basal ganglia	4	0.64	2.0
GTEx	Breast Mammary Tissue	13	0.66	2.0
GTEx	Breast Mammary Tissue (Male)	11	0.92	2.0
GTEx	Breast Mammary Tissue (Female)	14	0.85	2.0
GTEx	Cells EBV-transformed lymphocytes	13	0.91	2.1
GTEx	Cells Transformed fibroblasts	16	0.38	1.9
GTEx	Colon Sigmoid	11	0.75	2.0
GTEx	Colon Transverse	15	0.73	2.1
GTEx	Esophagus Gastroesophageal Junction	11	0.76	2.0
GTEx	Esophagus Mucosa	17	0.51	1.9
GTEx	Esophagus Muscularis	20	0.62	2.0
GTEx	Heart Atrial Appendage	11	0.70	2.0
GTEx	Heart Left Ventricle	12	0.78	2.1
GTEx	Liver	4	0.56	2.1
GTEx	Lung	17	0.59	2.0
GTEx	Muscle Skeletal	14	0.48	1.9
GTEx	Nerve Tibial	17	0.39	1.9
GTEx	Ovary	11	1.21	2.2
GTEx	Pancreas	9	0.55	2.0
GTEx	Pituitary	10	0.90	2.1
GTEx	Prostate	7	0.84	2.1
GTEx	Skin Not Sun Exposed Suprapubic	18	0.73	2.0
GTEx	Skin Sun Exposed Lower leg	16	0.44	1.9
GTEx	Small Intestine Terminal Ileum	9	1.95	2.4
GTEx	Spleen	9	0.64	2.1
GTEx	Stomach	11	0.76	2.0
GTEx	Testis	18	0.57	1.9
GTEx	Thyroid	20	0.50	1.9
GTEx	Uterus	8	1.41	2.2
GTEx	Vagina	10	1.57	2.2
GTEx	Whole Blood	9	0.45	1.9
METSIM	Adipose	6	0.13	1.7
NTR	Blood	7	0.29	1.8
ROSMAP	Brain Pre-frontal Cortex	30	0.68	2.0
YFS	Blood	5	0.11	1.6
CommonMind	Brain Pre-frontal Cortex	10	0.19	1.8
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	8	0.48	1.9
The Cancer Genome Atlas	Breast Invasive Carcinoma	12	0.27	1.8
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.36	1.7
The Cancer Genome Atlas	Colon Adenocarcinoma	3	0.15	1.8
The Cancer Genome Atlas	Esophageal Carcinoma	6	0.88	2.0
The Cancer Genome Atlas	Glioblastoma Multiforme	3	0.29	1.8
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	7	0.26	1.7
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	12	0.29	1.8
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	6	0.29	1.8
The Cancer Genome Atlas	Brain Lower Grade Glioma	10	0.23	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.18	1.8
The Cancer Genome Atlas	Lung Adenocarcinoma	11	0.37	1.8
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	12	0.48	1.8
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	8	0.50	1.8
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	5	0.30	1.8
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	6	0.45	1.9
The Cancer Genome Atlas	Prostate Adenocarcinoma	10	0.22	1.7
The Cancer Genome Atlas	Rectum Adenocarcinoma	4	0.58	1.8
The Cancer Genome Atlas	Soft Tissue Sarcoma	4	0.37	1.8
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.19	1.7
The Cancer Genome Atlas	Stomach Adenocarcinoma	6	0.36	1.7
The Cancer Genome Atlas	Testicular Germ Cell Tumors	6	0.47	1.7
The Cancer Genome Atlas	Thyroid Carcinoma	11	0.21	1.7
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.20	1.6