Best TWAS P=7.66e-09 · Best GWAS P=5.83e-08 conditioned to 0.891
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | 5.1 | -5.1 | 2.9e-07 | -0.95 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | 5.3 | -5.3 | 1.1e-07 | -0.97 | 0.02 | 0.87 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | 5.4 | 5.2 | 1.6e-07 | 0.91 | 0.04 | 0.95 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | 5.3 | -5.1 | 3.0e-07 | -0.96 | 0.02 | 0.98 | FALSE |
| 5 | YFS | Blood | SERPING1 | 0.04 | 0.04 | lasso | 6 | 0.04 | 1.2e-12 | 4.8 | 5.2 | 2.4e-07 | 0.74 | 0.16 | 0.84 | FALSE |
| 6 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | 5.1 | 5.8 | 7.7e-09 | 0.95 | 0.02 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | 5.3 | 5.3 | 1.0e-07 | 0.97 | 0.00 | 0.90 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | 5.4 | -5.4 | 8.3e-08 | -0.97 | 0.00 | 0.84 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | 5.1 | -5.1 | 2.9e-07 | -0.95 | 0.00 | 0.83 | FALSE |