[Hub]/) : Traits : Worrier / anxious feelings : ← →

chr10:103,527,782-105,647,095

Best TWAS P=2.45e-13 · Best GWAS P=1.06e-11 conditioned to 0.806

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	-4.0	-5.2	2.3e-07	0.63	0.06	0.66	FALSE
2	CommonMind	Brain Pre-frontal Cortex	AS3MT	0.17	0.16	lasso	9	0.15	4.5e-18	-4.1	5.2	2.1e-07	-0.88	0.31	0.69	FALSE
3	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-3.1	-6.1	9.2e-10	0.65	0.08	0.78	FALSE
4	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	2.9	5.3	1.2e-07	-0.70	0.07	0.80	FALSE
5	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	-6.1	6.6	4.1e-11	-0.92	0.04	0.89	FALSE
6	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	-6.1	-6.2	5.5e-10	0.89	0.07	0.92	FALSE
7	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	-6.5	-6.7	2.6e-11	0.61	0.06	0.86	FALSE
8	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	-6.5	-6.8	1.3e-11	0.79	0.05	0.85	FALSE
9	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	-6.6	-7.0	2.3e-12	0.69	0.04	0.71	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	-6.5	-6.4	1.7e-10	0.78	0.06	0.74	FALSE
11	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	-6.6	-7.1	1.6e-12	0.67	0.06	0.68	FALSE
12	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	5.4	-6.0	1.8e-09	0.42	0.04	0.07	FALSE
13	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-5.2	-6.7	1.9e-11	0.64	0.05	0.34	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	3.6	-5.7	1.1e-08	0.56	0.30	0.47	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	4.1	-5.3	9.6e-08	0.34	0.20	0.16	FALSE
16	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	1.5	5.8	6.3e-09	-0.66	0.04	0.52	FALSE
17	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	4.2	5.7	9.5e-09	-0.42	0.59	0.27	FALSE
18	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	-6.5	-6.7	2.3e-11	0.78	0.06	0.92	FALSE
19	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	-6.5	-6.6	3.4e-11	0.77	0.07	0.88	FALSE
20	GTEx	Pancreas	CYP17A1-AS1	0.11	0.06	lasso	5	0.06	1.1e-03	-6.8	-5.2	1.6e-07	0.85	0.03	0.80	FALSE
21	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-5.1	5.1	2.8e-07	-0.45	0.62	0.15	FALSE
22	GTEx	Thyroid	SFXN2	0.28	0.06	enet	32	0.15	1.1e-11	1.8	5.4	7.3e-08	-0.61	0.16	0.84	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-5.2	-5.2	2.6e-07	0.44	0.99	0.01	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	-6.5	-6.8	7.3e-12	0.77	0.07	0.93	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-6.8	7.3	2.5e-13	-0.94	0.01	0.99	TRUE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	-6.8	5.8	6.8e-09	-0.94	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	5.4	5.1	2.8e-07	-0.31	0.87	0.05	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	-4.1	5.1	2.9e-07	-0.87	0.02	0.81	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	-6.1	5.4	8.4e-08	-0.89	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	-6.8	6.8	1.3e-11	-1.00	0.00	0.99	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	AS3MT	0.34	0.38	lasso	6	0.38	4.4e-46	-4.1	5.4	7.8e-08	-0.92	0.32	0.68	FALSE
32	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	-6.1	6.1	1.1e-09	-0.93	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	-6.8	5.7	1.5e-08	-0.93	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	-6.1	6.6	5.5e-11	-0.94	0.02	0.81	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	-6.8	6.5	6.5e-11	-1.00	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	-6.3	6.2	7.5e-10	-0.68	0.06	0.91	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	-6.1	6.1	8.1e-10	-0.85	0.02	0.75	FALSE