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chr16:30,347,731-31,833,122

Best TWAS P=4.2e-08 · Best GWAS P=6.27e-08 conditioned to 0.313

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HSD3B7	0.05	0.06	lasso	4	0.07	5.5e-09	-5.4	-5.4	6.5e-08	1.00	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	-4.3	-5.2	1.6e-07	0.88	0.10	0.90	FALSE
3	GTEx	Adipose Subcutaneous	RP11-196G11.2	0.23	0.20	lasso	9	0.21	4.2e-17	-5.1	-5.2	1.8e-07	0.96	0.05	0.95	FALSE
4	GTEx	Artery Aorta	STX1B	0.17	0.18	lasso	6	0.15	1.9e-08	-5.2	-5.3	1.2e-07	0.98	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	4.4	-5.1	2.8e-07	0.82	0.13	0.87	FALSE
6	GTEx	Cells Transformed fibroblasts	RP11-196G11.2	0.14	0.14	lasso	6	0.13	2.9e-10	-5.3	-5.3	9.9e-08	0.98	0.02	0.98	FALSE
7	GTEx	Colon Transverse	RP11-196G11.2	0.24	0.11	lasso	5	0.15	1.9e-07	-4.9	-5.2	2.1e-07	0.94	0.03	0.97	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	-4.3	-5.3	1.3e-07	0.88	0.05	0.95	FALSE
9	GTEx	Esophagus Mucosa	STX1B	0.12	0.03	lasso	5	0.05	1.7e-04	-5.3	-5.1	3.0e-07	0.86	0.04	0.96	FALSE
10	GTEx	Esophagus Mucosa	RP11-196G11.2	0.09	0.03	enet	13	0.05	1.5e-04	-5.1	-5.3	9.9e-08	0.91	0.04	0.94	FALSE
11	GTEx	Esophagus Muscularis	STX4	0.05	0.05	lasso	3	0.03	6.7e-03	-4.9	-5.1	3.1e-07	0.97	0.03	0.94	FALSE
12	GTEx	Heart Left Ventricle	HSD3B7	0.12	0.08	lasso	3	0.07	2.0e-04	-5.1	-5.2	2.5e-07	0.94	0.05	0.93	FALSE
13	GTEx	Lung	RP11-196G11.2	0.21	0.12	enet	22	0.14	1.6e-10	-5.3	-5.2	2.6e-07	0.88	0.04	0.96	FALSE
14	GTEx	Muscle Skeletal	STX4	0.04	0.04	lasso	3	0.03	2.9e-04	-5.2	-5.2	2.2e-07	0.98	0.03	0.97	FALSE
15	GTEx	Nerve Tibial	HSD3B7	0.09	0.05	lasso	3	0.03	2.4e-03	-5.3	-5.2	1.5e-07	0.95	0.04	0.85	FALSE
16	GTEx	Nerve Tibial	RP11-196G11.2	0.17	0.22	lasso	6	0.22	2.3e-15	-4.9	-5.2	2.3e-07	0.96	0.03	0.97	FALSE
17	GTEx	Pituitary	HSD3B7	0.13	0.07	lasso	7	0.05	2.1e-02	-5.1	-5.2	2.2e-07	0.90	0.05	0.86	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	RP11-196G11.2	0.22	0.21	lasso	9	0.26	3.2e-14	-5.1	-5.2	2.5e-07	0.94	0.05	0.95	FALSE
19	GTEx	Skin Sun Exposed Lower leg	HSD3B7	0.12	0.17	lasso	5	0.16	2.7e-13	-5.0	-5.1	2.7e-07	0.92	0.05	0.95	FALSE
20	GTEx	Skin Sun Exposed Lower leg	RP11-196G11.2	0.16	0.15	lasso	7	0.15	4.0e-12	-5.1	-5.1	2.9e-07	0.96	0.03	0.96	FALSE
21	GTEx	Thyroid	RP11-196G11.2	0.11	0.14	lasso	2	0.14	3.5e-11	-5.3	-5.2	1.7e-07	0.96	0.03	0.97	FALSE
22	GTEx	Uterus	RP11-196G11.2	0.18	0.16	lasso	20	0.15	5.4e-04	-5.1	-5.1	2.9e-07	0.95	0.04	0.92	FALSE
23	METSIM	Adipose	RP11-196G11.2	0.13	0.17	lasso	9	0.16	2.2e-23	-5.4	-5.3	8.9e-08	1.00	0.02	0.98	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	STX1B	0.08	0.10	lasso	7	0.10	3.0e-12	-5.2	-5.2	2.1e-07	0.90	0.05	0.95	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	HSD3B7	0.03	0.05	lasso	6	0.02	3.0e-04	-5.0	-5.1	3.1e-07	0.94	0.03	0.97	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	-3.5	-5.3	1.1e-07	0.86	0.08	0.78	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	RP11-196G11.2	0.12	0.12	lasso	4	0.12	1.1e-14	-5.4	-5.4	8.2e-08	1.00	0.02	0.98	FALSE
28	YFS	Blood	STX4	0.03	0.06	lasso	2	0.05	4.3e-17	-5.3	-5.3	1.2e-07	0.98	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD3B7	0.03	0.03	blup	31	0.04	5.2e-08	-5.1	-5.2	2.1e-07	0.92	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	-4.3	-5.3	1.1e-07	0.89	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYST1	0.08	0.04	blup	34	0.07	7.2e-08	4.3	-5.5	4.2e-08	0.91	0.01	0.99	TRUE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	3.9	5.1	2.7e-07	-0.83	0.03	0.69	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	-5.0	-5.3	1.2e-07	0.92	0.02	0.85	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	-5.1	-5.4	5.5e-08	0.93	0.01	0.58	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD3B7	0.09	0.12	blup	31	0.11	4.1e-05	-5.1	-5.4	5.9e-08	0.92	0.02	0.95	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	HSD3B7	0.20	0.27	lasso	12	0.28	1.8e-27	-5.2	-5.2	2.5e-07	0.90	0.02	0.98	FALSE