TWAS hub - SETD1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0250	0.0062	0.028	0.011	0.008	0.016	0.016	0.00022	0.01300	0.034	0.00380	0.004
2	ROSMAP	Brain Pre-frontal Cortex	0.0206	0.0107	0.0015	0.006	0.024	0.007	0.022	0.006	0.04900	0.00043	0.039	0.00059	0.052

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hip circumference	17.4	74.9	88.5	7.8	9.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	16.9	35.8	45.9	-5.1	-6.8
Waist circumference	15.8	57.8	73.3	6.5	8.6
Lupus	14.9	22.6	43.3	6.6	1.4
Alzheimer’s Disease (including proxy)	14.6	21.1	29.7	-3.5	-5.5
Arm fat mass (left)	13.8	56.5	70.6	6.5	8.4
Leg fat mass (left)	13.7	53.6	65.8	6.4	8.1
Number of incorrect matches in round	13.4	22.2	23.6	-4.6	-4.9
Irritability	13.4	22.7	26.1	-4.4	-5.1
Leg fat mass (right)	13.3	51.6	63.8	6.3	8.0
Triglycerides	13.1	21.4	24.1	4.3	4.9
Arm fat mass (right)	13.1	54.1	67.2	6.4	8.2
Body mass index (BMI)	13.0	55.5	65.4	6.7	8.1
Leg fat percentage (left)	13.0	47.2	58.7	6.0	7.7
Arm fat percentage (left)	12.9	51.3	65.4	6.1	8.1
Arm fat percentage (right)	12.7	50.0	63.2	6.1	8.0
Body fat percentage	12.7	50.2	64.6	6.0	8.0
Whole body fat mass	12.6	52.5	66.1	6.2	8.1
Tense / ‘highly strung’	12.4	20.6	28.2	-3.6	-5.3
Cholesterol lowering medication	12.4	18.3	18.3	4.3	4.3
Leg fat percentage (right)	11.9	43.2	54.7	5.6	7.4
Weight	11.8	58.2	69.7	6.8	8.3
Trunk fat mass	11.7	50.2	64.0	6.0	8.0
Trunk fat percentage	11.4	45.7	59.1	5.7	7.7
Medication: Atorvastatin	11.0	13.5	14.9	3.9	3.5
Comparative body size at age 10	10.9	30.2	40.8	4.4	6.4
Worry (Nagel 2018)	10.8	22.7	36.1	-3.0	-6.0
Nervous feelings	10.7	20.0	30.2	-3.1	-5.5
Overall health rating	10.7	22.9	24.2	4.9	4.7
Diastolic blood pressure, automated reading	10.3	31.9	34.0	5.5	5.8
BMI	9.5	55.4	70.6	6.3	8.4
Illnesses of siblings	9.5	13.3	15.1	-3.4	-3.9
Blood Red Count	9.4	91.1	118.8	-8.0	-10.9
Cardiovascular Disease	9.2	30.4	36.8	4.9	6.1
Neuroticism (Nagel 2018)	9.1	21.5	28.8	-3.8	-5.4
Alcohol intake frequency.	9.1	21.2	23.0	4.4	4.8
Forced expiratory volume in 1-second (FEV1), Best measure	8.9	28.3	37.7	-4.3	-6.1
Alzheimer’s Disease (in mother)	8.8	10.4	13.7	-2.7	-3.7
High cholesterol (Self-reported)	8.7	15.4	18.2	3.6	4.3
Pain experienced in last month	8.5	14.2	16.0	-3.5	-4.0
High blood pressure (siblings)	8.4	12.1	15.0	3.0	3.9
Worrier / anxious feelings	8.0	15.2	23.9	-2.6	-4.9
Vascular/heart problems diagnosed by doctor	8.0	21.8	26.1	-4.2	-5.1
Neuroticism	7.8	18.8	25.6	-3.4	-5.1
Wheeze or whistling in the chest in last year	7.7	13.8	17.9	3.1	4.2
Neuroticism score	7.6	15.8	21.2	-3.2	-4.6
High blood pressure	7.2	20.0	25.2	3.8	5.0
Hypertension (Self-reported)	7.0	19.4	25.2	3.7	5.0
Fractured/broken bones in last 5 years	6.9	8.9	11.1	3.3	2.6
Lung FVC	6.8	34.4	48.6	-4.5	-7.0
Medication for cholesterol	6.8	10.3	14.1	-2.5	-3.8
Frequency of tenseness / restlessness in last 2 weeks	6.7	10.4	15.8	-2.2	-4.0
Suffer from ‘nerves’	6.6	10.4	14.9	-2.4	-3.9
Blood White Count	6.5	47.8	56.0	-6.3	-7.5
Number of treatments/medications taken	6.4	11.5	14.3	3.0	3.8
Forced expiratory volume in 1-second (FEV1)	6.3	21.2	29.4	-3.6	-5.4
Medication: Cholesterol lowering	6.2	9.6	11.3	2.8	3.4
Arm predicted mass (left)	6.2	31.6	35.0	5.3	5.9
Arm predicted mass (right)	5.9	30.0	32.7	5.2	5.7
Hearing difficulty/problems: Yes	5.8	8.8	9.3	3.0	2.9
Basal metabolic rate	5.8	31.8	36.2	5.2	6.0
Pain all over the body in last month	5.7	6.1	7.2	2.2	2.7
Forced vital capacity (FVC), Best measure	5.7	20.7	26.7	-3.8	-5.2
Leg fat-free mass (left)	5.6	29.9	33.2	5.2	5.8
Leg predicted mass (left)	5.6	29.4	32.8	5.1	5.7
Knee pain experienced in last month	5.6	8.7	9.4	2.8	3.1
Arm fat-free mass (left)	5.6	28.4	31.7	5.0	5.6
Financial difficulties in last 2 years	5.5	7.4	8.0	2.6	2.8
Arm fat-free mass (right)	5.5	28.3	31.0	5.0	5.6
Myopia	5.5	8.0	9.0	2.6	3.0
Pulse rate, automated reading	5.3	17.1	18.3	4.0	4.3
Medication: Blood pressure	5.3	10.1	14.4	2.4	3.8
Chronic bronchitis/emphysema (father)	5.2	6.1	7.6	2.2	2.8
Neuroticism (2016)	5.1	7.4	8.0	-2.6	-2.8
Primary Biliary Cirrhosis	5.1	7.3	7.5	2.7	2.7
Hand grip strength (left)	5.1	13.6	19.0	2.9	4.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.1	6.1	7.3	2.7	2.2
Leg fat-free mass (right)	5.1	27.4	29.6	5.0	5.4
Leg predicted mass (right)	5.1	27.3	29.8	5.0	5.5
Medication: Ramipril	5.0	6.4	7.2	2.4	2.7
Pulse wave Arterial Stiffness index	5.0	5.8	6.8	2.6	2.2
Medication: Bendroflumethiazide	5.0	7.6	11.1	2.0	3.3
Heel T-Score	4.9	38.8	40.8	-6.1	-6.4
Number of self-reported non-cancer illnesses	4.9	8.6	10.2	2.6	3.2
Lung FEV1/FVC ratio	4.8	24.4	29.7	-4.4	-5.5
Ever had hysterectomy (womb removed)	4.7	5.3	7.4	2.7	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	4.7	6.1	6.6	-2.4	-2.6
Asthma	4.6	9.0	12.9	2.3	3.6
Pulse wave peak to peak time	4.6	5.4	6.3	-2.5	-2.1
Unable to work because of sickness or disability	4.6	5.9	6.4	2.3	2.5
Forced vital capacity (FVC)	4.5	17.2	23.4	-3.3	-4.8
Chest pain or discomfort	4.5	6.5	7.7	2.8	2.3
Medication: Simvastatin	4.4	6.5	7.2	2.4	2.7
Chronic bronchitis/emphysema (mother)	4.4	5.1	6.8	1.8	2.6
Respiratory disease	4.2	9.4	13.5	2.3	3.7
Father’s age at death	4.2	5.6	5.8	-2.4	-2.3
Asthma (self-reported)	4.2	8.3	11.8	2.2	3.4
Medication: Co-codamol	4.1	4.8	5.7	2.0	2.4
Whole body fat-free mass	4.0	23.0	24.8	4.6	5.0
Whole body water mass	4.0	22.7	24.7	4.5	5.0
Alzheimer’s Disease (in father)	3.9	4.2	6.8	-1.3	-2.6
Townsend deprivation index at recruitment	3.9	5.4	8.0	1.7	2.8
Pack years of smoking	3.9	5.7	5.8	2.4	2.4
Relative age voice broke	3.8	5.8	7.7	2.0	2.8
HDL Cholesterol	3.7	6.1	7.0	-2.6	-2.3
Sensitivity / hurt feelings	3.7	6.3	6.5	-2.5	-2.5
Hand grip strength (right)	3.7	10.1	14.7	2.3	3.8
Mood swings	3.7	6.7	8.5	-2.2	-2.9
Medication: Paracetamol	3.7	5.7	5.9	2.3	2.4
Medication: Paracetamol	3.6	5.9	8.2	1.9	2.9
Pack years adult smoking proportion	3.5	5.3	5.6	2.4	2.2
Osteoporosis (self-reported)	3.5	4.3	5.5	2.4	1.8
Headache pain in last month	3.4	5.8	5.9	2.4	2.4
Had menopause	3.1	3.9	4.2	1.9	2.0
Falls in the last year	3.1	4.2	7.6	0.9	2.8
Exposure to tobacco smoke outside home	3.1	4.1	4.5	1.9	2.1
Blood Eosinophil Count	3.0	22.8	25.9	-5.1	-4.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	4.8	-2.1	-2.2
Worry too long after embarrassment	3.0	5.0	5.0	-2.2	-2.2
Number of operations (self-reported)	2.9	4.3	5.3	1.8	2.3
Depressed Affect (Nagel 2018)	2.8	5.8	8.5	-1.8	-2.9
Supplements: Zinc	2.8	3.0	4.2	-2.0	-1.4
Impedance of leg (right)	2.8	13.5	15.4	-3.9	-3.4
Medication for cholesterol, blood pressure or diabetes	2.8	4.6	5.2	-2.0	-2.3
Medication for pain relief, constipation, heartburn	2.8	4.7	6.6	-1.7	-2.6
Trunk fat-free mass	2.7	15.4	16.3	3.8	4.0
Happiness	2.7	3.3	4.7	-1.4	-2.2
Health satisfaction	2.7	3.5	4.4	2.1	1.6
Diabetes diagnosed by doctor	2.7	4.4	7.1	1.3	2.7
Tinnitus: Yes, but not now, but have in the past	2.6	2.7	2.9	1.7	1.6
Trunk predicted mass	2.6	15.0	15.8	3.8	4.0
Age at last live birth	2.6	3.8	4.4	-2.1	-1.8
Miserableness	2.6	4.4	5.7	-1.8	-2.4
Diabetes (mother)	2.5	3.2	3.4	1.9	1.7
Taking other prescription medications	2.5	3.9	4.2	1.9	2.0
Impedance of leg (left)	2.5	12.1	13.5	-3.7	-3.3
Had other major operations	2.5	3.1	3.5	1.6	1.9
Birth weight of first child	2.5	4.5	7.4	1.3	2.7
Long-standing illness, disability or infirmity	2.5	3.8	4.6	1.7	2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	3.5	-1.9	-1.4
Breast Cancer	2.4	5.8	7.4	2.7	2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.4	6.5	-2.1	-2.6
Impedance of arm (right)	2.4	11.1	13.3	-3.6	-3.0
Number of full brothers	2.4	3.0	3.0	1.7	1.7
Qualifications: College or University degree	2.4	7.5	8.8	-2.5	-3.0
Impedance of whole body	2.4	12.4	14.3	-3.8	-3.2
Type 2 Diabetes (T2D) (2018)	2.3	4.4	7.3	1.2	2.7
Number of full sisters	2.3	2.8	4.8	0.9	2.2
Breastfed as a baby	2.2	2.8	5.1	0.7	2.2
Age at first live birth	2.2	4.0	4.2	-2.1	-1.9
Back pain experienced in last month	2.2	3.2	3.5	1.9	1.7
Diabetes (self-reported)	2.1	3.2	5.9	0.8	2.4
Emphysema/chronic bronchitis	2.1	2.3	3.6	1.0	1.9
Hearing aid user	2.1	2.4	2.9	1.7	1.4
Leg pain on walking	2.0	2.5	3.4	-1.8	-1.3
Body Mass Index (BMI) (2010)	1.9	2.7	3.3	1.4	1.8
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	2.8	-1.7	-1.3
Impedance of arm (left)	1.9	9.0	10.7	-3.3	-2.7
Ever depressed for a whole week	1.9	2.4	3.7	-1.0	-1.9
Irritable Bowel Disease (IBD)	1.8	4.3	6.4	-2.5	-1.5
Relative age of first facial hair	1.8	3.6	5.7	1.3	2.4
Qualifications: None of the above	1.8	3.8	5.3	2.3	1.5
Prospective memory result	1.8	2.2	2.3	-1.5	-1.5
Supplements: Fish oil (including cod liver oil)	1.8	2.3	2.5	-1.5	-1.6
Crohns Disease (2017)	1.7	3.7	3.7	-1.9	-1.9
HbA1C	1.7	1.9	1.9	1.4	1.4
Illnesses of mother	1.7	2.1	2.3	-1.5	-1.3
Neck or shoulder pain in last month	1.7	2.4	3.5	1.1	1.9
Medication: Allopurinol	1.7	2.3	3.4	-1.1	-1.9
Illnesses of siblings: Diabetes	1.7	2.1	3.2	1.0	1.8
LDL Cholesterol	1.6	2.5	4.3	2.1	0.8
Medication: Metformin	1.6	2.2	3.8	0.8	1.9
Alcohol intake versus 10 years previously	1.6	2.4	3.3	1.2	1.8
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.3	-1.2	-1.5
Medication: Ventolin 100micrograms inhaler	1.6	2.0	2.4	1.3	1.6
Alcohol drinker status: Previous	1.6	1.8	2.0	1.3	1.4
Major Depression (MDD)	1.5	1.8	2.5	-1.6	-1.0
Hearing difficulty/problems with background noise	1.5	2.4	2.5	1.6	1.5
Hair/balding pattern: Pattern 3	1.5	2.2	2.6	1.6	1.3
Heart disease (siblings)	1.5	1.9	2.2	1.5	1.2
Supplements: Glucosamine	1.4	1.8	2.5	-1.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.4	-1.5	-0.9
Crohns Disease (2012)	1.3	2.1	2.8	-1.7	-1.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.9	1.7	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	3.1	-1.6	-1.8
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	1.9	-1.3	-1.4
Medication: Lansoprazole	1.3	1.5	1.8	1.4	1.1
Pulse wave reflection index	1.3	1.6	2.3	1.5	0.9
Tinnitus: Yes, now most or all of the time	1.3	1.5	1.6	1.3	1.2
Average weekly spirits intake	1.2	1.5	1.5	1.2	1.2
Medication: Amlodipine	1.2	1.7	3.2	-1.8	-0.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.6	0.5	1.6
Medication: Lisinopril	1.2	1.5	2.1	0.9	1.5
Ulcerative Colitis (UC)	1.1	2.1	4.1	-2.0	-0.5
Waist Hip Ratio (WHR)	1.1	4.9	8.2	-2.9	-1.3
Coronary Artery Disease (CAD)	1.0	1.1	1.7	-1.3	-0.8
Fed-up feelings	1.0	1.9	2.4	-1.2	-1.5
Fluid intelligence score	1.0	2.2	2.3	1.5	1.4
Medication: Blood pressure	1.0	1.8	2.6	1.0	1.6
Medication: Aspirin	1.0	1.3	1.5	1.1	1.2
Illnesses of father: Heart disease	1.0	1.4	2.6	-1.6	-0.4
Medication: Gliclazide	1.0	1.1	2.2	-0.2	1.5
Rheumatoid Arthritis	0.9	1.2	2.2	0.5	1.5
Current tobacco smoking	0.9	1.5	2.1	0.9	1.5
Mouth/teeth dental problems	0.9	1.3	1.6	-1.0	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.8	0.7	1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.8	-0.4	1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.2	-0.9	-1.1
Friendships satisfaction	0.9	1.1	1.2	-1.0	-1.1
Ovarian Cancer	0.8	1.1	1.7	-1.3	-0.6
Smoking Status	0.8	2.0	3.7	0.5	1.9
Hayfever, allergic rhinitis or eczema	0.8	1.8	2.6	-1.6	-1.0
Pulse rate	0.8	1.3	1.3	1.1	1.1
Loud music exposure frequency	0.8	0.9	1.8	1.4	0.0
Gout (self-reported)	0.8	1.1	1.3	-0.9	-1.2
Birth weight	0.8	1.6	2.5	0.9	1.6
Medication: Ibuprofen	0.8	1.0	1.4	0.7	1.2
Supplements: Vitamin C	0.8	1.0	1.3	-1.1	-0.8
Illnesses of father: High blood pressure	0.8	1.0	1.1	0.9	1.0
Average weekly beer plus cider intake	0.8	1.2	1.2	-1.1	-1.1
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	-0.1	-1.4
Mean Putamen Volume	0.7	0.8	1.5	-1.2	-0.3
Ulcerative Colitis	0.7	1.0	1.9	-1.4	-0.4
Blood Platelet Count	0.7	8.2	12.2	-2.1	-3.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.2	-1.5	-0.8
Loneliness, isolation	0.7	0.9	1.2	-0.9	-1.1
Commuting to job workplace: Walk	0.7	0.7	1.0	-0.7	-1.0
Medication: Aspirin	0.7	0.9	1.0	1.0	0.9
Guilty feelings	0.7	1.0	1.3	-0.8	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.0	-0.8	-1.0
Age at First Birth	0.6	0.9	1.4	-0.6	-1.2
Diabetes (father)	0.6	0.8	0.9	-1.0	-0.8
Sitting height	0.6	3.9	7.4	-0.7	-2.7
Number of children fathered	0.6	0.7	1.2	1.1	-0.3
Mineral and other dietary supplements	0.6	0.7	1.1	1.1	0.6
Commuting to job workplace: Public transport	0.6	0.8	1.0	0.7	1.0
Commuting to job workplace: Cycle	0.6	0.7	1.4	-1.2	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.0	1.0	-0.7
Vitamin and mineral supplements	0.5	0.7	1.3	-0.4	-1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.6	0.8	0.7
Time employed in main current job	0.5	0.6	1.2	0.1	1.1
Peak expiratory flow (PEF)	0.5	1.2	2.1	-0.5	-1.4
Blood clot in the leg (DVT)	0.5	0.7	1.2	1.1	0.3
Qualifications: nursing, teaching	0.5	0.8	0.9	-0.8	-0.9
Breast cancer (self-reported)	0.5	0.6	0.7	0.9	0.7
Wears glasses or contact lenses	0.5	0.5	0.6	0.7	0.8
Schizophrenia (2014)	0.4	0.9	1.6	-1.2	-0.5
Height	0.4	8.5	13.9	1.8	3.7
Multivitamins +/- minerals	0.4	0.6	1.1	-1.0	0.2
Noisy workplace	0.4	0.5	0.7	-0.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.9	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.0	-1.0
Smoking status: Current	0.4	0.6	1.0	0.5	1.0
Alcohol drinker status: Never	0.4	0.4	0.8	0.9	0.3
Age started oral contraceptive pill	0.4	0.5	0.9	0.9	0.4
Supplements: Calcium	0.4	0.5	0.6	0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.1	1.0	0.3
Depression (Nagel 2018)	0.3	0.5	1.0	-0.0	-1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	0.9	0.9	0.8
Allergy or Eczema	0.3	0.7	0.8	-0.9	-0.7
Hypothyroidism (self reported)	0.3	0.7	1.1	-0.6	-1.0
Systolic blood pressure, automated reading	0.3	1.0	1.2	1.1	0.9
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.8	-0.5
Past tobacco smoking	0.3	0.5	0.9	0.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.3	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.8	-0.9	-0.8
Lung cancer (father)	0.3	0.3	0.3	-0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	0.6	0.7
Glaucoma (self-reported)	0.3	0.3	0.6	-0.1	-0.8
Medication: Omeprazole	0.3	0.4	0.8	-0.9	-0.2
Had major operations	0.3	0.4	0.7	0.2	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.6	-0.8	-0.3
Smoking status: Previous	0.3	0.5	0.8	-0.3	0.9
Average weekly red wine intake	0.3	0.5	0.8	0.9	-0.3
Average weekly champagne plus white wine intake	0.3	0.5	0.7	-0.5	-0.8
Mother’s age at death	0.3	0.4	0.6	-0.8	-0.5
Risk taking	0.3	0.4	0.5	0.5	0.7
Schizophrenia (2018)	0.2	0.5	0.8	-0.9	-0.4
Severe depression (siblings)	0.2	0.2	0.3	-0.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.0	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.4	-0.4	0.6
Heart attack	0.2	0.2	0.4	0.2	0.6
Allergy	0.2	0.5	1.0	-0.1	-1.0
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	0.4	0.8
Depression (self-reported)	0.2	0.2	0.4	0.6	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.3	0.7
Shortness of breath walking on level ground	0.2	0.3	0.5	0.3	0.7
Migraine (self-reported)	0.2	0.3	0.5	-0.7	0.1
Heart disease (mother)	0.2	0.2	0.3	-0.4	-0.5
Comparative height size at age 10	0.2	0.8	1.5	-0.4	1.2
Family relationship satisfaction	0.2	0.3	0.5	0.7	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.4	0.6	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.6	0.1
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.1	0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	0.6	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.2	-0.3
Prostate Cancer	0.1	0.2	0.3	-0.6	-0.1
Hair Pigment	0.1	3.7	4.8	-2.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.5	-0.0
Angina	0.1	0.1	0.1	-0.4	-0.1
Average weekly fortified wine intake	0.1	0.1	0.2	0.1	-0.4
Age when periods started (menarche)	0.1	0.2	0.2	0.5	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.5	-0.1
High blood pressure (mother)	0.1	0.1	0.3	-0.1	0.5
Alcohol usually taken with meals	0.1	0.2	0.3	0.5	-0.2
Number of live births	0.1	0.1	0.2	0.2	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.2	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.5	0.0
Angina (self-reported)	0.1	0.1	0.2	-0.4	-0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.0	0.5
Ever smoked	0.1	0.2	0.3	-0.5	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.1	0.6
Reaction Time	0.0	0.1	0.1	-0.2	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	-0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.2	0.2
Systolic Blood Pressure	0.0	0.1	0.1	-0.3	0.3
Chronotype (morning person)	0.0	0.0	0.0	0.0	0.1
Tanning	0.0	0.3	0.3	0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	0.1	-0.1
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.1	0.2
Maternal smoking around birth	0.0	0.0	0.0	0.2	0.0
Medication: Atenolol	0.0	0.0	0.0	0.0	0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.3	0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.4	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	0.1
Standing height	0.0	0.4	0.7	0.4	0.8
Length of working week for main job	0.0	0.0	0.1	-0.3	-0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.2	-0.2
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.0	0.3
Mean time to correctly identify matches	0.0	0.0	0.0	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.2	-0.0
Ever had bowel cancer screening	0.0	0.0	0.0	0.0	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.3	-0.0
Ever taken oral contraceptive pill	0.0	0.0	0.0	0.2	0.0
Financial situation satisfaction	0.0	0.0	0.1	0.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.0	0.2

Hub : Genes

SETD1A

Models

Trait associations