TWAS hub - MYST1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0370	0.0240	1.7e-03	0.027	0.028	0.030	NA	0.029	2.3e-03	1.8e-03	1.2e-03	NA	1.6e-03
2	TCGA	Breast Invasive Carcinoma	0.0544	0.0256	1.5e-14	0.045	0.077	0.073	NA	0.071	1.3e-09	2.1e-15	1.2e-14	NA	2.2e-14
3	TCGA	Cervical Squamous Cell Carcinoma	0.2570	0.1080	6.2e-04	0.006	0.052	0.044	NA	0.012	1.6e-01	1.4e-03	3.2e-03	NA	7.7e-02
4	TCGA	Glioblastoma Multiforme	0.1820	0.1160	2.5e-04	0.066	0.106	0.089	NA	0.074	4.8e-03	4.2e-04	1.2e-03	NA	3.0e-03
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0753	0.0426	7.3e-08	0.040	0.066	0.053	NA	0.062	2.7e-05	7.2e-08	1.4e-06	NA	1.7e-07
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1188	0.0517	1.5e-10	0.089	0.099	0.097	NA	0.092	3.1e-10	2.8e-11	5.1e-11	NA	1.5e-10
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0720	0.0520	1.1e-03	0.008	0.030	0.044	NA	0.017	1.0e-01	7.7e-03	1.6e-03	NA	3.3e-02
8	TCGA	Brain Lower Grade Glioma	0.1642	0.0731	3.1e-12	0.083	0.120	0.107	NA	0.115	1.0e-09	1.5e-13	3.6e-12	NA	6.1e-13
9	TCGA	Liver Hepatocellular Carcinoma	0.1610	0.0780	2.5e-04	0.085	0.097	0.112	NA	0.111	8.5e-05	2.6e-05	6.2e-06	NA	7.1e-06
10	TCGA	Lung Adenocarcinoma	0.0927	0.0575	4.0e-04	0.033	0.031	0.029	NA	0.027	9.4e-05	1.4e-04	2.1e-04	NA	3.1e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0763	0.0350	6.2e-08	0.083	0.071	0.079	NA	0.078	1.1e-09	1.9e-08	2.8e-09	NA	3.4e-09
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0320	0.0200	1.2e-03	0.051	0.034	0.022	NA	0.029	2.4e-04	2.1e-03	1.2e-02	NA	4.6e-03
13	TCGA	Pancreatic Adenocarcinoma	0.2240	0.1030	3.0e-09	0.146	0.214	0.193	NA	0.182	1.0e-06	2.1e-09	1.5e-08	NA	4.3e-08
14	TCGA	Pheochromocytoma and Paraganglioma	0.0750	0.0480	1.8e-03	0.093	0.068	0.064	NA	0.069	1.6e-04	1.2e-03	1.5e-03	NA	1.0e-03
15	TCGA	Prostate Adenocarcinoma	0.1929	0.0764	5.6e-17	0.118	0.181	0.172	NA	0.176	2.4e-12	1.5e-18	1.2e-17	NA	4.2e-18
16	TCGA	Rectum Adenocarcinoma	0.1270	0.0910	5.9e-03	0.046	0.057	0.001	NA	0.033	3.1e-02	1.9e-02	3.0e-01	NA	5.7e-02
17	TCGA	Stomach Adenocarcinoma	0.0370	0.0290	7.7e-03	0.021	0.023	0.017	NA	0.016	1.1e-02	8.7e-03	2.0e-02	NA	2.3e-02
18	TCGA	Testicular Germ Cell Tumors	0.1340	0.0790	9.5e-05	0.063	0.116	0.089	NA	0.116	2.9e-03	6.8e-05	4.8e-04	NA	6.9e-05
19	TCGA	Thyroid Carcinoma	0.1250	0.0580	3.0e-13	0.101	0.135	0.136	NA	0.142	4.7e-10	4.7e-13	3.4e-13	NA	1.1e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Alzheimer’s Disease (including proxy)	22.9	33.2	39.9	-6.0	-6.0	-6.0	-5.3	-5.0	-5.9	-5.5	-6.1	-3.7	-5.5	-5.5	-5.7	-6.1	-6.1	-5.9	-6.1	-5.9	-6.3	-6.1
Waist circumference	21.5	78.8	102.0	8.9	8.9	9.1	9.1	8.0	9.1	9.2	9.7	3.1	8.2	7.5	9.7	9.4	8.2	9.6	9.9	9.1	10.1	9.6
Hip circumference	21.1	90.9	118.8	9.4	9.7	9.7	10.4	8.8	9.4	9.4	10.2	3.1	8.4	7.7	10.8	10.4	8.7	10.1	10.9	10.0	10.9	10.2
Arm fat mass (left)	17.9	73.5	97.6	8.4	8.5	9.1	9.1	7.6	8.6	8.8	9.2	2.8	7.6	7.0	9.5	9.2	7.9	9.2	9.8	8.8	9.9	9.2
Arm fat mass (right)	17.4	71.8	96.0	8.3	8.4	9.2	8.9	7.5	8.5	8.7	9.1	2.7	7.5	6.8	9.4	9.1	7.8	9.2	9.7	8.7	9.8	9.1
Leg fat mass (right)	16.6	64.2	84.5	7.9	8.1	8.3	8.7	7.4	8.0	7.8	8.6	2.6	7.2	6.5	9.0	8.7	7.3	8.5	9.1	8.4	9.2	8.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	16.6	35.1	45.2	-6.0	-6.5	-4.0	-6.7	-6.7	-5.9	-5.3	-6.1	-2.4	-5.5	-5.3	-6.7	-6.5	-5.5	-5.9	-6.5	-6.5	-6.2	-6.4
Leg fat mass (left)	16.5	64.3	84.6	7.9	8.1	8.2	8.7	7.4	8.0	7.9	8.6	2.5	7.2	6.5	9.1	8.7	7.3	8.5	9.2	8.4	9.2	8.6
Whole body fat mass	16.3	68.1	88.2	8.2	8.3	8.5	8.6	7.5	8.3	8.4	8.9	3.0	7.4	6.9	9.1	8.9	7.7	8.8	9.3	8.5	9.4	8.9
Body mass index (BMI)	15.7	67.0	95.5	7.7	8.0	9.1	9.5	7.3	7.8	8.3	8.7	1.2	6.8	5.8	9.8	8.9	6.9	8.8	9.8	8.4	9.8	8.8
Nervous feelings	15.6	29.1	34.7	-5.9	-5.7	-4.4	-4.8	-5.6	-5.7	-5.2	-5.8	-3.5	-5.9	-5.4	-5.1	-5.4	-5.6	-5.6	-5.4	-5.6	-5.5	-5.8
Weight	15.6	76.8	102.0	8.7	8.6	9.8	8.9	7.5	8.9	8.8	9.5	3.3	8.0	7.3	9.5	9.3	8.2	9.4	9.8	9.0	10.1	9.4
Arm fat percentage (left)	15.6	62.3	81.9	7.8	8.0	8.0	8.4	7.2	7.9	8.0	8.4	2.8	6.9	6.5	8.9	8.6	7.4	8.5	9.0	8.2	9.1	8.4
Worry (Nagel 2018)	15.4	32.4	42.3	-6.1	-6.4	-3.9	-5.6	-6.5	-5.9	-4.4	-5.8	-4.1	-6.0	-5.9	-5.5	-6.1	-5.8	-5.5	-5.7	-6.3	-5.5	-6.1
Trunk fat mass	15.4	66.1	83.4	8.2	8.3	8.2	8.2	7.3	8.3	8.2	8.8	3.5	7.4	7.1	8.8	8.8	7.8	8.7	9.0	8.4	9.1	8.7
Body fat percentage	15.4	61.0	76.7	7.8	8.1	7.2	8.3	7.4	7.9	7.9	8.2	3.0	7.0	6.7	8.7	8.5	7.4	8.3	8.8	8.2	8.7	8.3
Arm fat percentage (right)	15.3	60.4	80.1	7.6	7.8	7.8	8.4	7.0	7.7	8.0	8.2	2.6	6.7	6.4	8.8	8.5	7.2	8.4	8.9	8.1	8.9	8.3
Trunk fat percentage	14.4	57.7	70.2	7.7	7.9	7.0	7.8	7.2	7.8	7.7	8.1	3.4	6.9	6.8	8.2	8.2	7.3	8.1	8.4	7.9	8.4	8.1
Triglycerides	14.2	23.3	31.9	4.7	4.9	4.4	5.4	4.6	4.8	4.9	5.4	1.5	4.1	3.9	5.4	5.6	4.4	4.9	5.4	5.1	5.4	5.1
Alzheimer’s Disease (in mother)	14.1	16.5	22.2	-4.1	-4.2	-4.7	-3.9	-3.3	-4.1	-4.0	-4.3	-2.0	-3.6	-3.6	-4.2	-4.4	-4.0	-4.3	-4.5	-4.1	-4.6	-4.3
High blood pressure (siblings)	14.1	20.3	28.3	4.5	4.5	3.9	5.3	4.7	4.4	4.2	4.5	1.1	4.0	3.6	5.3	4.8	3.9	4.9	5.2	4.9	5.2	5.0
Leg fat percentage (left)	13.8	49.9	66.7	6.9	7.2	6.7	8.0	6.8	6.9	7.0	7.4	2.1	6.0	5.7	8.2	7.8	6.4	7.5	8.1	7.5	8.1	7.6
Leg fat percentage (right)	13.4	48.5	64.8	6.8	7.2	6.4	7.9	6.8	6.8	6.8	7.3	2.2	6.1	5.7	8.1	7.7	6.3	7.3	8.0	7.4	7.9	7.5
Tense / ‘highly strung’	13.3	22.0	30.0	-4.9	-5.3	-2.5	-4.9	-5.5	-4.8	-4.4	-4.6	-2.8	-4.5	-4.7	-4.9	-5.0	-4.7	-4.8	-4.9	-5.1	-4.6	-5.0
Number of incorrect matches in round	13.2	22.0	33.2	-4.4	-4.6	-4.7	-5.8	-4.5	-4.3	-4.6	-5.0	-0.5	-3.8	-3.2	-5.8	-5.2	-3.9	-4.9	-5.6	-5.0	-5.5	-5.0
BMI	12.9	75.1	106.1	8.2	8.5	9.6	9.8	7.7	8.3	9.0	9.3	1.4	7.3	6.2	10.2	9.4	7.4	9.3	10.2	8.8	10.3	9.3
Cardiovascular Disease	11.9	39.2	50.3	6.3	6.4	6.0	6.7	6.1	6.2	6.2	6.6	2.0	5.9	5.2	7.1	6.5	5.8	6.7	7.1	6.5	7.1	6.8
Overall health rating	10.6	22.8	33.4	4.4	4.6	5.3	5.2	4.0	4.6	5.7	5.2	0.1	3.9	3.2	5.8	5.0	3.8	5.4	5.8	4.6	5.8	5.1
Hypertension (Self-reported)	10.6	29.6	37.8	5.6	5.5	6.1	5.2	4.9	5.5	5.2	6.0	2.2	5.5	4.7	5.8	5.5	5.1	5.7	6.0	5.5	6.2	6.0
Illnesses of siblings	10.5	14.8	25.0	-3.5	-3.9	-3.5	-5.0	-4.0	-3.5	-3.4	-3.9	-0.1	-3.0	-2.5	-4.9	-4.3	-2.9	-4.0	-4.7	-4.2	-4.5	-4.2
Diastolic blood pressure, automated reading	10.5	32.5	40.1	6.0	5.7	6.1	5.0	4.8	6.1	5.8	6.1	3.4	5.5	5.4	5.7	5.9	5.9	6.1	6.1	5.8	6.3	6.1
Neuroticism (Nagel 2018)	10.4	24.4	40.6	-5.2	-5.9	-1.8	-5.4	-6.4	-5.0	-3.8	-4.6	-3.5	-4.7	-5.2	-5.1	-5.5	-5.0	-4.7	-5.0	-5.7	-4.5	-5.2
Worrier / anxious feelings	10.1	19.1	30.2	-4.9	-5.2	-1.8	-4.1	-5.5	-4.6	-2.9	-4.1	-4.2	-4.8	-5.1	-3.8	-4.6	-4.7	-3.9	-4.0	-5.0	-3.8	-4.5
Vascular/heart problems diagnosed by doctor	10.1	27.6	38.2	-5.3	-5.2	-6.2	-5.4	-4.7	-5.1	-5.0	-5.7	-1.5	-5.0	-4.2	-5.9	-5.3	-4.7	-5.5	-6.0	-5.3	-6.2	-5.8
High blood pressure	10.0	27.9	37.5	5.4	5.2	6.1	5.2	4.7	5.3	5.2	5.8	1.8	5.2	4.4	5.7	5.3	4.9	5.6	5.9	5.3	6.1	5.8
Suffer from ‘nerves’	9.9	15.5	24.7	-4.5	-4.0	-3.0	-3.0	-4.1	-4.4	-3.4	-4.3	-3.5	-5.0	-4.4	-3.1	-3.7	-4.4	-3.9	-3.5	-4.1	-3.6	-4.2
Medication: Bendroflumethiazide	9.9	15.0	18.9	4.1	3.7	4.2	3.6	3.3	4.1	3.8	3.9	2.3	3.9	3.6	3.8	3.8	4.0	4.3	4.1	4.0	4.3	4.2
Medication for cholesterol	9.4	14.2	17.6	-3.8	-4.1	-2.8	-4.1	-4.1	-3.8	-3.8	-3.8	-1.4	-3.6	-3.4	-4.2	-3.8	-3.4	-4.1	-4.2	-4.0	-4.0	-4.2
Arm predicted mass (left)	8.9	45.4	71.6	6.6	6.4	8.5	7.0	5.5	6.7	6.5	7.5	1.7	6.2	5.1	7.4	7.1	5.9	7.2	7.7	6.8	8.0	7.3
Financial difficulties in last 2 years	8.8	11.8	17.2	3.2	3.4	4.1	3.5	2.6	3.5	4.0	3.8	0.6	2.5	2.6	4.0	3.8	2.9	3.8	4.1	3.3	4.1	3.6
Alcohol intake frequency.	8.6	20.0	32.3	4.3	4.1	5.7	4.5	3.3	4.4	5.2	4.8	0.7	3.9	3.3	5.0	4.4	3.9	5.2	5.2	4.3	5.4	4.8
Arm fat-free mass (left)	8.6	43.8	72.1	6.5	6.2	8.5	6.7	5.3	6.6	6.4	7.4	1.8	6.1	5.0	7.2	6.9	5.8	7.1	7.5	6.7	7.9	7.2
Arm predicted mass (right)	8.4	42.8	70.7	6.5	6.2	8.4	6.5	5.3	6.6	6.2	7.4	2.1	6.3	5.1	7.0	6.8	5.9	6.9	7.4	6.6	7.7	7.1
Medication: Blood pressure	8.4	16.0	19.6	4.2	4.1	4.3	3.7	3.7	4.2	3.7	4.2	2.1	4.1	3.7	4.1	4.0	3.9	4.2	4.3	4.1	4.4	4.4
Basal metabolic rate	8.4	46.6	76.7	6.8	6.4	8.8	6.7	5.3	6.9	6.7	7.6	2.4	6.3	5.4	7.3	7.1	6.3	7.3	7.7	6.9	8.1	7.4
Cholesterol lowering medication	8.2	12.1	19.9	3.3	3.8	2.0	4.3	3.8	3.3	3.7	3.4	0.5	2.7	2.8	4.5	3.7	2.9	3.7	4.1	3.7	3.9	3.7
Comparative body size at age 10	8.1	22.5	28.6	5.0	5.3	3.2	5.0	5.3	4.8	3.8	4.6	3.3	4.5	4.8	4.9	5.2	4.9	4.7	4.9	5.3	4.8	5.0
Arm fat-free mass (right)	7.9	40.3	68.1	6.3	6.0	8.2	6.4	5.1	6.4	6.0	7.2	1.8	6.0	4.8	6.9	6.6	5.6	6.7	7.2	6.4	7.5	6.9
Pain experienced in last month	7.8	13.0	18.3	-3.4	-4.1	-2.3	-4.3	-3.8	-3.6	-3.9	-3.4	-1.3	-2.6	-3.2	-4.3	-4.2	-3.3	-3.9	-4.2	-3.9	-3.9	-3.7
Neuroticism	7.7	18.5	31.3	-4.4	-5.1	-1.1	-4.8	-5.6	-4.4	-3.7	-3.9	-2.6	-3.9	-4.4	-4.6	-4.8	-4.2	-4.3	-4.4	-4.9	-4.0	-4.5
Townsend deprivation index at recruitment	7.6	10.6	15.4	3.1	3.3	2.4	3.7	3.4	3.3	3.7	3.4	0.4	2.7	2.5	3.9	3.5	2.7	3.7	3.8	3.4	3.7	3.6
Leg fat-free mass (left)	7.5	39.8	65.6	6.2	6.0	8.1	6.3	4.9	6.4	6.1	7.0	2.2	5.7	5.0	6.8	6.7	5.8	6.7	7.2	6.4	7.5	6.8
Forced expiratory volume in 1-second (FEV1), Best measure	7.5	24.0	43.8	-4.6	-5.5	-2.1	-6.6	-6.3	-4.4	-4.7	-4.6	-0.5	-4.0	-3.7	-6.2	-5.4	-3.9	-5.0	-5.7	-5.4	-5.1	-5.2
Leg predicted mass (left)	7.4	39.3	65.1	6.2	6.0	8.1	6.3	4.9	6.3	6.0	6.9	2.2	5.6	5.0	6.8	6.7	5.7	6.7	7.1	6.4	7.5	6.8
Knee pain experienced in last month	7.4	11.6	19.1	3.1	3.6	2.9	4.3	3.3	3.1	3.4	3.5	0.6	2.4	2.5	4.4	4.0	3.0	3.5	4.1	3.6	4.0	3.5
Alzheimer’s Disease (in father)	7.2	7.8	9.2	-3.0	-2.9	-2.7	-2.3	-2.5	-3.0	-2.5	-2.9	-2.0	-2.9	-2.8	-2.7	-2.8	-2.9	-3.0	-2.8	-2.9	-3.0	-3.0
Lung FVC	7.1	35.9	54.5	-6.1	-7.0	-3.1	-7.0	-7.4	-5.8	-4.7	-5.8	-3.3	-5.6	-5.7	-6.8	-6.7	-5.8	-5.6	-6.5	-6.8	-6.0	-6.3
Number of full sisters	7.1	8.7	11.0	3.2	3.2	1.6	2.9	3.3	3.1	2.9	2.6	2.0	2.8	3.1	2.9	3.0	3.1	3.3	3.0	3.2	2.9	3.1
High cholesterol (Self-reported)	7.1	12.6	18.6	3.5	3.7	1.7	4.3	4.3	3.5	3.7	3.6	0.6	3.4	2.9	4.3	3.6	3.0	3.8	4.0	3.7	3.7	3.9
Diabetes (self-reported)	7.0	10.9	15.3	3.4	3.4	3.5	3.0	3.1	3.4	3.3	3.9	1.6	3.6	2.9	3.2	3.5	3.2	3.3	3.5	3.3	3.5	3.5
Leg predicted mass (right)	6.9	36.7	64.8	6.0	5.7	8.1	5.9	4.5	6.1	5.9	6.7	2.1	5.4	4.8	6.5	6.4	5.5	6.5	6.9	6.1	7.2	6.5
Unable to work because of sickness or disability	6.9	8.9	14.7	2.6	2.8	3.3	3.5	2.4	2.8	3.8	3.1	-0.4	2.1	1.8	3.7	3.1	2.2	3.5	3.7	2.8	3.7	3.1
Leg fat-free mass (right)	6.8	36.3	65.1	5.9	5.7	8.1	5.9	4.5	6.1	5.9	6.7	2.0	5.4	4.7	6.5	6.3	5.5	6.5	6.9	6.0	7.2	6.5
Number of treatments/medications taken	6.6	11.8	14.7	3.7	3.8	1.9	3.2	3.8	3.7	3.5	3.5	2.4	3.6	3.6	3.4	3.5	3.5	3.6	3.4	3.6	3.3	3.7
Neuroticism score	6.6	13.8	25.5	-4.0	-4.5	-0.5	-4.1	-5.0	-3.7	-3.0	-3.3	-2.6	-3.5	-4.0	-3.9	-4.0	-3.7	-3.6	-3.7	-4.2	-3.3	-3.9
Medication: Cholesterol lowering	6.6	10.2	16.7	3.1	3.4	2.0	4.0	3.6	3.0	3.2	3.3	0.4	2.7	2.4	4.1	3.5	2.7	3.3	3.8	3.4	3.5	3.5
Pulse wave Arterial Stiffness index	6.4	7.5	11.6	2.7	2.5	3.1	2.5	2.1	2.8	3.4	3.1	0.9	2.5	2.2	2.9	2.8	2.7	3.2	3.0	2.6	3.2	2.9
Mouth/teeth dental problems: Loose teeth	6.2	7.4	10.0	2.9	2.4	3.2	2.4	2.2	2.9	2.9	2.9	1.3	2.9	2.4	2.6	2.6	2.7	3.2	2.8	2.7	3.1	3.0
Diabetes diagnosed by doctor	6.2	10.2	14.1	3.1	3.4	3.4	3.3	3.1	3.1	3.2	3.8	1.0	3.2	2.5	3.5	3.5	2.8	3.1	3.6	3.2	3.5	3.4
Blood Red Count	6.0	57.6	94.1	-8.0	-9.2	-1.7	-8.2	-9.7	-7.8	-5.5	-6.7	-6.3	-6.8	-8.5	-7.7	-8.7	-8.0	-7.0	-7.4	-8.8	-6.7	-7.7
Wheeze or whistling in the chest in last year	6.0	10.7	14.8	3.1	3.5	2.4	3.7	3.2	3.2	3.5	3.1	1.5	2.4	2.9	3.8	3.7	3.2	3.6	3.7	3.5	3.7	3.3
Whole body fat-free mass	6.0	34.5	63.8	5.8	5.4	8.0	5.7	4.3	5.9	5.7	6.6	1.8	5.5	4.5	6.2	6.1	5.3	6.3	6.6	5.8	7.0	6.4
Whole body water mass	6.0	34.0	62.9	5.8	5.4	7.9	5.7	4.3	5.9	5.6	6.6	1.9	5.4	4.5	6.2	6.0	5.2	6.2	6.6	5.8	7.0	6.3
Pulse wave peak to peak time	5.9	6.9	11.0	-2.5	-2.4	-3.0	-2.7	-2.1	-2.6	-3.3	-2.9	-0.5	-2.3	-1.9	-2.9	-2.7	-2.4	-3.1	-3.0	-2.5	-3.1	-2.7
Medication: Atorvastatin	5.9	7.3	10.8	2.7	3.0	1.7	3.1	3.1	2.6	2.8	2.8	0.7	2.5	2.3	3.3	2.8	2.4	2.8	3.1	2.8	2.9	2.9
Falls in the last year	5.8	7.8	12.2	2.7	2.8	2.1	3.1	2.6	2.8	3.5	2.6	0.6	2.0	2.3	3.3	3.0	2.6	3.4	3.3	2.9	3.2	2.9
Forced expiratory volume in 1-second (FEV1)	5.6	18.8	34.0	-4.2	-5.0	-1.2	-5.7	-5.8	-4.0	-3.8	-4.0	-1.0	-3.7	-3.7	-5.4	-4.7	-3.6	-4.3	-4.9	-4.9	-4.3	-4.7
Medication: Lisinopril	5.4	6.9	12.5	3.0	2.7	3.0	1.9	2.7	2.8	2.2	3.3	1.7	3.5	2.5	2.0	2.5	2.6	2.4	2.4	2.6	2.5	2.9
Type 2 Diabetes (T2D) (2018)	5.3	9.9	16.0	3.1	3.0	4.0	3.0	2.6	3.1	3.3	3.7	0.9	3.0	2.4	3.3	3.4	2.8	3.3	3.5	3.1	3.6	3.4
Irritability	5.2	8.7	16.4	-2.8	-3.5	0.4	-4.0	-4.1	-2.8	-2.3	-2.0	-1.9	-1.8	-3.0	-3.6	-3.5	-3.0	-2.9	-3.1	-3.6	-2.7	-2.9
Medication: Co-codamol	5.0	5.8	9.6	2.1	2.3	2.7	2.7	2.2	2.1	3.1	2.6	-0.4	2.1	1.4	2.9	2.3	1.8	2.7	2.9	2.1	2.9	2.5
Hand grip strength (left)	4.9	12.9	18.5	3.5	3.9	3.3	4.1	3.6	3.4	3.0	3.6	1.9	2.9	3.2	4.0	4.3	3.6	3.4	4.0	4.0	4.0	3.7
Forced vital capacity (FVC), Best measure	4.9	17.8	40.2	-3.7	-4.9	-1.5	-6.3	-5.8	-3.4	-3.5	-3.8	0.2	-3.2	-2.7	-5.8	-4.8	-3.0	-3.9	-5.1	-4.7	-4.4	-4.4
Number of self-reported non-cancer illnesses	4.9	8.6	10.6	3.1	3.1	1.6	3.0	3.2	3.1	3.2	2.9	1.4	2.8	2.9	3.1	2.9	2.8	3.3	3.1	3.1	3.0	3.2
Fractured/broken bones in last 5 years	4.9	6.3	10.8	2.4	2.7	2.3	3.2	2.4	2.4	1.8	2.5	0.6	1.7	2.0	3.3	2.9	2.0	2.4	3.1	2.8	3.0	2.7
Emphysema/chronic bronchitis	4.8	5.4	6.6	2.4	2.4	2.0	1.9	2.1	2.5	2.5	2.3	1.8	2.3	2.4	2.2	2.4	2.6	2.6	2.3	2.4	2.4	2.4
Frequency of tenseness / restlessness in last 2 weeks	4.7	7.3	11.4	-3.1	-3.0	-0.6	-2.1	-3.3	-3.0	-2.1	-2.5	-3.1	-3.2	-3.4	-2.0	-2.6	-3.2	-2.6	-2.1	-3.0	-2.1	-2.7
Medication: Simvastatin	4.7	6.9	11.5	2.5	2.8	2.0	3.3	2.9	2.4	2.4	2.8	0.3	2.3	1.9	3.4	2.8	2.1	2.6	3.1	2.8	3.0	2.8
Birth weight of first child	4.7	8.6	12.1	3.3	3.4	1.6	2.4	3.2	3.3	2.6	2.9	2.8	3.0	3.5	2.5	3.1	3.3	2.9	2.7	3.1	2.7	3.0
Number of operations (self-reported)	4.7	7.0	10.9	2.7	2.5	3.3	2.5	2.3	2.7	2.5	3.1	0.9	3.0	2.1	2.8	2.5	2.4	2.8	2.9	2.6	3.0	3.0
Depressed Affect (Nagel 2018)	4.6	9.8	20.4	-3.4	-3.9	0.3	-3.2	-4.5	-3.2	-2.6	-2.7	-2.6	-3.1	-3.6	-3.0	-3.3	-3.2	-2.9	-2.8	-3.5	-2.4	-3.2
Medication for cholesterol, blood pressure or diabetes	4.6	7.6	11.7	-2.6	-2.8	-2.6	-3.3	-2.8	-2.6	-2.9	-3.1	-0.0	-2.6	-1.9	-3.4	-2.9	-2.1	-2.9	-3.3	-2.8	-3.2	-3.1
Pulse rate, automated reading	4.5	14.7	23.9	4.4	4.0	2.3	2.4	3.7	4.5	3.2	3.7	4.7	4.4	4.9	2.6	3.6	4.7	3.9	3.1	4.0	3.3	3.9
Trunk fat-free mass	4.4	25.2	51.7	4.9	4.5	7.2	4.8	3.5	5.1	4.8	5.8	1.5	4.7	3.8	5.3	5.2	4.5	5.4	5.7	5.0	6.1	5.4
Trunk predicted mass	4.3	24.8	51.4	4.9	4.5	7.2	4.7	3.5	5.0	4.8	5.8	1.5	4.7	3.8	5.2	5.1	4.5	5.3	5.6	4.9	6.0	5.4
Number of full brothers	4.3	5.4	8.7	2.1	2.4	2.9	3.0	2.1	2.0	2.1	2.5	-0.5	1.6	1.3	2.9	2.7	1.5	2.3	2.9	2.4	2.8	2.5
Breastfed as a baby	4.2	5.2	10.0	2.8	2.6	0.8	1.2	2.5	2.7	1.7	2.3	2.9	2.8	3.2	1.5	2.0	2.7	2.0	1.7	2.3	1.7	2.3
Exposure to tobacco smoke outside home	4.2	5.6	10.3	1.9	2.3	2.1	2.9	2.2	2.1	3.2	2.4	-0.5	1.6	1.3	3.0	2.6	1.7	2.8	2.9	2.2	2.8	2.5
Body Mass Index (BMI) (2010)	4.1	5.6	8.1	2.3	2.5	1.8	2.8	2.5	2.3	2.3	2.6	0.6	2.0	1.9	2.8	2.8	2.1	2.4	2.7	2.6	2.6	2.5
Had other major operations	4.0	4.9	8.2	2.3	2.0	2.9	1.9	1.6	2.4	2.0	2.4	1.4	2.2	2.1	2.1	2.2	2.2	2.4	2.3	2.3	2.5	2.4
Forced vital capacity (FVC)	4.0	15.4	34.3	-3.6	-4.6	-0.9	-5.9	-5.6	-3.3	-2.8	-3.4	-0.1	-3.0	-2.8	-5.4	-4.4	-2.8	-3.5	-4.7	-4.5	-4.0	-4.2
Smoking Status	3.8	9.0	15.2	2.7	3.2	3.9	3.8	2.9	2.5	2.0	3.4	-0.2	2.5	1.7	3.8	3.5	2.0	2.5	3.8	3.2	3.6	3.2
HDL Cholesterol	3.7	6.2	8.5	-2.4	-2.5	-2.4	-2.9	-2.3	-2.5	-2.6	-2.8	-0.5	-2.0	-1.9	-2.9	-2.9	-2.1	-2.6	-2.9	-2.6	-2.8	-2.6
Medication: Metformin	3.7	5.2	7.4	2.4	2.4	2.5	1.9	2.2	2.4	1.9	2.7	1.6	2.7	2.1	2.1	2.3	2.3	2.1	2.3	2.3	2.3	2.4
Pain all over the body in last month	3.7	4.0	5.7	2.1	2.4	1.4	2.1	2.3	2.1	1.4	1.9	1.0	1.8	2.0	2.2	2.2	1.8	1.9	2.2	2.2	2.1	2.2
Neck or shoulder pain in last month	3.7	5.3	7.4	2.4	2.3	2.6	1.8	1.7	2.5	2.7	2.5	1.0	2.1	2.1	2.3	2.3	2.2	2.7	2.5	2.2	2.6	2.5
Chronic bronchitis/emphysema (father)	3.6	4.2	6.3	2.1	2.5	0.8	2.4	2.3	2.1	1.7	1.8	1.2	1.2	2.1	2.4	2.5	1.9	2.0	2.3	2.4	2.1	2.1
Medication: Blood pressure	3.6	6.4	12.9	2.4	2.3	3.6	2.5	2.1	2.4	2.3	3.1	0.4	2.7	1.7	2.8	2.5	2.1	2.5	2.9	2.5	3.0	2.8
Hand grip strength (right)	3.5	9.6	12.3	3.2	3.3	2.9	3.2	3.0	3.1	2.3	3.2	2.1	2.9	2.9	3.2	3.5	3.2	2.9	3.3	3.5	3.3	3.3
Diabetes (mother)	3.4	4.4	9.1	1.9	2.0	3.0	1.9	1.3	2.0	2.6	2.4	0.2	1.6	1.4	2.4	2.2	1.7	2.3	2.5	1.8	2.6	2.2
Medication: Paracetamol	3.4	5.7	9.3	2.1	2.5	1.8	2.9	2.1	2.2	3.0	2.2	0.3	1.3	1.8	3.0	2.8	2.1	2.8	2.9	2.4	2.8	2.4
Medication: Gliclazide	3.4	3.8	7.2	2.2	1.8	2.5	1.2	1.7	2.2	1.6	2.5	1.7	2.7	1.9	1.3	1.8	2.1	1.8	1.7	1.9	1.9	2.1
Happiness	3.3	4.0	7.5	-1.8	-1.9	-0.9	-2.7	-2.4	-1.8	-2.4	-1.7	-0.1	-1.5	-1.4	-2.5	-2.2	-1.8	-2.4	-2.3	-2.2	-2.2	-2.0
Heel T-Score	3.2	25.2	37.0	-4.7	-4.9	-4.7	-5.8	-4.5	-4.9	-5.8	-5.2	-0.6	-3.8	-3.7	-6.1	-5.5	-4.3	-5.7	-6.0	-5.1	-5.9	-5.3
Neuroticism (2016)	3.1	4.4	6.8	-2.3	-2.5	-0.4	-2.6	-2.5	-2.0	-1.5	-1.5	-1.7	-1.2	-2.5	-2.2	-2.5	-2.4	-2.0	-2.1	-2.6	-1.9	-2.0
Respiratory disease	2.9	6.5	10.9	2.6	2.8	1.2	2.4	2.7	2.7	3.3	2.4	1.7	2.4	2.6	2.4	2.5	2.8	3.0	2.6	2.5	2.4	2.6
Chronic bronchitis/emphysema (mother)	2.9	3.4	5.8	1.8	2.2	0.2	2.0	2.4	2.0	1.8	1.8	1.1	1.7	1.9	2.1	2.0	1.8	1.8	1.9	2.0	1.7	1.9
Impedance of whole body	2.9	14.7	35.8	-2.6	-2.9	-6.0	-5.4	-2.5	-2.7	-3.7	-3.9	2.6	-2.1	-0.7	-5.4	-4.0	-1.8	-4.0	-5.2	-3.6	-5.2	-4.0
Past tobacco smoking	2.8	5.2	8.8	-2.1	-2.5	-2.8	-3.0	-2.3	-1.9	-1.3	-2.7	-0.0	-1.8	-1.4	-2.9	-2.8	-1.6	-1.7	-2.8	-2.5	-2.7	-2.4
Impedance of arm (right)	2.8	13.1	29.8	-2.4	-2.7	-5.5	-5.3	-2.6	-2.4	-3.3	-3.7	2.8	-2.0	-0.4	-5.1	-3.8	-1.4	-3.6	-4.9	-3.3	-4.8	-3.7
Medication: Allopurinol	2.8	3.7	5.6	-1.6	-1.8	-2.3	-2.3	-1.4	-1.8	-1.9	-1.8	-0.8	-1.2	-1.4	-2.2	-2.4	-1.9	-2.1	-2.3	-2.1	-2.4	-1.9
Had major operations	2.8	3.3	4.7	1.8	1.8	1.5	2.1	1.9	1.8	2.2	2.0	-0.0	1.8	1.3	2.2	1.7	1.4	2.1	2.1	1.8	2.0	2.1
Miserableness	2.8	4.8	8.8	-2.5	-2.4	-0.2	-1.7	-3.0	-2.4	-2.2	-2.1	-1.9	-2.8	-2.6	-1.7	-1.9	-2.4	-2.3	-1.8	-2.2	-1.7	-2.3
Relative age of first facial hair	2.7	5.5	7.5	2.5	2.7	2.5	2.3	2.0	2.4	1.1	2.1	2.2	1.8	2.5	2.4	2.7	2.6	2.0	2.5	2.7	2.6	2.4
Impedance of leg (right)	2.7	13.3	33.4	-2.7	-2.8	-5.8	-4.7	-2.2	-2.9	-3.8	-3.7	1.6	-2.0	-1.1	-4.8	-3.9	-2.1	-4.0	-4.8	-3.4	-5.0	-3.7
Relative age voice broke	2.7	4.1	6.7	2.2	2.6	1.0	1.9	2.4	2.1	0.2	1.8	2.5	1.9	2.6	1.9	2.3	2.2	1.2	1.8	2.5	1.7	2.0
Medication: Ramipril	2.7	3.5	6.1	1.5	2.0	2.3	2.3	1.6	1.6	1.3	2.1	0.4	1.2	1.2	2.5	2.4	1.5	1.5	2.3	2.0	2.3	1.9
Age at first live birth	2.7	4.7	8.3	-1.8	-2.0	-2.4	-2.8	-2.0	-1.8	-2.4	-2.3	0.6	-1.5	-1.0	-2.9	-2.4	-1.5	-2.3	-2.8	-2.2	-2.7	-2.3
Mood swings	2.7	5.0	10.7	-2.5	-2.8	0.6	-2.3	-3.3	-2.2	-1.6	-1.6	-2.0	-2.0	-2.7	-2.2	-2.3	-2.4	-2.0	-2.0	-2.6	-1.7	-2.2
Primary Biliary Cirrhosis	2.6	3.7	4.9	2.1	2.0	1.9	1.9	1.7	2.1	1.2	1.9	1.4	1.7	1.9	1.9	2.1	1.9	1.9	2.0	2.2	2.1	2.1
Blood Eosinophil Count	2.6	20.3	46.4	-4.1	-3.5	-6.8	-4.5	-2.8	-4.3	-5.3	-4.8	-1.0	-4.1	-2.9	-4.5	-4.5	-4.2	-5.5	-5.1	-4.3	-5.6	-4.7
Impedance of arm (left)	2.6	11.9	26.8	-2.1	-2.5	-5.2	-5.2	-2.4	-2.2	-3.3	-3.4	3.1	-1.7	-0.2	-5.0	-3.5	-1.2	-3.5	-4.7	-3.1	-4.6	-3.5
Illnesses of father: High blood pressure	2.6	3.2	6.6	1.4	1.6	1.9	2.5	1.9	1.3	1.7	1.8	-1.2	1.4	0.5	2.6	1.6	0.9	1.9	2.4	1.7	2.2	2.0
Impedance of leg (left)	2.5	12.2	28.3	-2.6	-2.8	-5.3	-4.6	-2.3	-2.7	-3.5	-3.5	1.6	-1.9	-1.1	-4.7	-3.7	-2.0	-3.8	-4.7	-3.3	-4.7	-3.6
Asthma	2.5	4.9	8.5	2.4	2.7	0.4	1.9	2.4	2.4	1.8	1.7	2.8	1.8	2.9	1.8	2.5	2.8	2.1	1.9	2.4	1.8	2.0
Myopia	2.5	3.7	6.8	1.8	2.2	0.3	2.6	2.3	1.8	1.3	1.3	1.3	1.1	1.9	2.4	2.3	2.0	1.9	2.1	2.4	1.9	1.9
Ever had hysterectomy (womb removed)	2.4	2.7	5.4	1.3	1.7	1.7	2.3	1.4	1.4	1.9	1.7	-0.5	0.8	0.8	2.3	1.9	1.1	1.6	2.2	1.6	2.0	1.7
Qualifications: College or University degree	2.4	7.7	18.6	-2.3	-2.2	-4.3	-3.0	-1.8	-2.4	-3.2	-3.1	0.4	-2.2	-1.3	-3.2	-2.8	-2.1	-3.2	-3.4	-2.6	-3.6	-2.9
Chest pain or discomfort	2.4	3.4	6.1	1.5	1.9	1.7	2.4	1.8	1.6	2.4	2.0	-0.5	1.3	1.0	2.5	2.1	1.3	2.0	2.3	1.7	2.2	1.9
Lung FEV1/FVC ratio	2.3	11.7	23.0	-3.5	-3.3	-1.5	-3.2	-3.4	-3.8	-4.8	-3.2	-1.7	-3.1	-3.4	-3.3	-3.4	-3.6	-4.5	-3.4	-3.4	-3.4	-3.6
Medication: Aspirin	2.3	3.1	6.0	1.5	1.8	1.1	2.5	2.2	1.4	1.6	2.0	-0.2	1.6	1.0	2.5	1.9	1.3	1.5	2.1	1.8	1.9	1.9
Medication: Paracetamol	2.3	3.5	6.6	1.4	1.9	1.7	2.5	1.5	1.6	2.5	1.7	-0.2	0.6	1.1	2.6	2.3	1.5	2.1	2.4	1.8	2.3	1.8
Current tobacco smoking	2.2	3.6	7.0	1.7	1.7	2.6	1.9	1.5	1.7	2.0	2.3	-0.3	1.8	1.1	2.2	1.8	1.3	2.0	2.3	1.7	2.3	2.1
Medication for pain relief, constipation, heartburn	2.2	3.7	6.2	-1.8	-2.2	-0.6	-2.1	-2.0	-2.0	-2.5	-1.9	-0.7	-1.2	-1.8	-2.3	-2.3	-1.8	-2.1	-2.2	-1.9	-2.0	-1.9
LDL Cholesterol	2.1	3.3	6.0	1.5	1.6	1.4	2.4	1.9	1.5	2.5	2.2	-0.9	1.4	0.8	2.4	2.0	1.0	1.9	2.2	1.7	2.1	1.9
Had menopause	2.1	2.6	3.6	1.8	1.9	0.9	1.5	1.7	1.7	1.3	1.6	1.3	1.5	1.8	1.6	1.8	1.7	1.5	1.6	1.8	1.6	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.4	1.3	1.8	0.9	2.1	2.0	1.3	1.8	1.8	-0.1	1.3	0.9	2.1	1.9	1.2	1.5	1.9	1.6	1.7	1.6
Illnesses of siblings: Diabetes	2.1	2.6	4.5	1.5	1.7	2.1	1.9	1.4	1.4	1.1	1.8	-0.1	1.2	1.0	2.1	1.8	1.0	1.4	2.0	1.7	2.0	1.8
Ever smoked	2.1	3.7	7.5	1.7	2.0	2.7	2.4	1.8	1.5	1.3	2.3	-0.3	1.6	1.0	2.5	2.2	1.2	1.6	2.4	2.0	2.3	2.0
Taking other prescription medications	2.0	3.0	5.1	2.0	1.9	1.5	1.2	1.8	2.0	1.6	2.0	1.3	2.3	1.9	1.5	1.5	1.8	1.7	1.7	1.7	1.7	2.0
Hair/balding pattern: Pattern 3	2.0	2.9	4.5	1.8	2.1	0.8	1.6	2.0	1.7	0.7	1.5	2.0	1.6	2.1	1.7	1.9	2.0	1.2	1.6	2.0	1.6	1.7
Smoking status: Previous	2.0	2.9	6.5	1.5	2.0	1.8	2.5	1.9	1.3	0.5	1.8	0.0	1.1	1.0	2.4	2.3	1.1	1.1	2.2	2.0	2.0	1.7
Asthma (self-reported)	2.0	3.9	7.0	2.1	2.5	0.1	1.6	2.1	2.1	1.9	1.5	2.6	1.5	2.6	1.7	2.3	2.5	1.9	1.7	2.1	1.6	1.8
Heart disease (siblings)	2.0	2.4	6.7	0.8	0.9	2.6	2.3	1.0	0.8	1.4	1.6	-1.8	0.7	-0.2	2.3	1.5	0.4	1.5	2.1	1.3	2.1	1.5
Depression (Nagel 2018)	1.9	2.8	6.4	-2.0	-1.8	-0.2	-0.8	-2.1	-2.0	-1.2	-1.4	-2.5	-2.3	-2.3	-0.7	-1.4	-2.0	-1.6	-0.9	-1.7	-1.0	-1.6
Sensitivity / hurt feelings	1.9	3.2	6.2	-1.8	-2.1	-0.3	-2.4	-2.5	-1.7	-1.3	-1.5	-0.6	-1.5	-1.6	-2.1	-2.0	-1.5	-1.7	-1.9	-2.1	-1.7	-1.9
Systolic blood pressure, automated reading	1.9	5.7	13.4	2.1	1.8	3.7	2.6	1.8	2.0	2.8	2.8	-0.8	2.5	1.0	2.7	2.1	1.6	2.7	2.8	2.0	3.0	2.6
Age at last live birth	1.9	2.8	4.5	-1.6	-1.7	-1.7	-1.7	-1.7	-1.6	-1.9	-2.1	-0.1	-1.8	-1.1	-1.8	-1.8	-1.4	-1.6	-1.8	-1.6	-1.8	-1.8
Handedness (chirality/laterality): Left-handed	1.9	2.2	4.5	1.5	1.7	0.1	2.0	2.1	1.4	1.3	1.2	0.5	1.1	1.4	1.7	1.7	1.3	1.6	1.6	1.8	1.4	1.6
Supplements: Fish oil (including cod liver oil)	1.9	2.4	3.7	-1.6	-1.9	-1.2	-1.4	-1.4	-1.6	-1.3	-1.5	-1.4	-1.1	-1.7	-1.7	-1.9	-1.8	-1.4	-1.7	-1.7	-1.6	-1.5
Alcohol drinker status: Previous	1.9	2.2	4.7	1.0	1.2	2.0	2.2	1.1	1.0	1.7	1.4	-1.1	0.8	0.3	2.1	1.4	0.7	1.6	2.0	1.3	2.0	1.5
Pack years of smoking	1.9	2.8	4.3	1.6	1.9	1.1	2.1	2.0	1.6	1.0	1.8	0.6	1.4	1.4	2.0	2.0	1.4	1.4	1.9	1.9	1.8	1.8
Pulse wave reflection index	1.8	2.2	5.0	1.1	1.1	2.2	1.8	0.9	1.2	2.1	1.7	-1.0	1.0	0.4	2.0	1.5	0.8	1.7	1.9	1.2	1.9	1.5
High blood pressure (mother)	1.7	2.5	4.9	1.4	1.3	2.2	1.6	1.0	1.5	2.0	1.7	-0.2	1.3	0.9	1.8	1.5	1.1	1.9	1.9	1.4	2.0	1.7
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	6.7	-0.8	-1.2	-2.6	-2.0	-0.9	-0.9	-1.5	-1.7	1.4	-0.7	0.0	-2.1	-1.6	-0.5	-1.3	-2.0	-1.2	-2.0	-1.4
Father’s age at death	1.7	2.2	5.8	-1.2	-1.4	-1.1	-2.4	-1.6	-1.1	-1.2	-1.1	0.3	-0.7	-0.8	-2.2	-1.6	-1.1	-1.6	-2.0	-1.7	-1.9	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	5.0	-1.8	-2.0	-0.5	-1.7	-2.2	-1.6	-1.1	-1.5	-1.2	-1.7	-1.8	-1.6	-1.7	-1.6	-1.4	-1.6	-1.8	-1.4	-1.7
Birth weight	1.7	3.6	7.6	1.6	1.9	2.8	2.4	1.4	1.5	1.6	2.0	-0.1	1.1	1.0	2.5	2.3	1.4	1.8	2.5	2.0	2.5	1.9
Osteoporosis (self-reported)	1.7	2.2	3.0	1.6	1.7	0.8	1.4	1.4	1.6	1.2	1.4	1.3	1.1	1.7	1.6	1.7	1.6	1.5	1.5	1.7	1.5	1.5
Pack years adult smoking proportion	1.6	2.4	3.5	1.5	1.8	1.3	1.8	1.7	1.5	1.0	1.7	0.6	1.3	1.3	1.9	1.8	1.3	1.4	1.8	1.8	1.7	1.7
Qualifications: A levels/AS levels or equivalent	1.6	3.5	17.4	-1.3	-1.0	-4.2	-1.9	-0.5	-1.3	-1.8	-2.4	1.3	-1.4	-0.2	-2.1	-1.7	-0.8	-1.8	-2.3	-1.4	-2.5	-1.9
Headache pain in last month	1.5	2.6	6.5	1.1	1.6	1.1	2.6	1.6	1.2	1.9	1.3	-0.5	0.5	0.7	2.4	2.0	1.1	1.8	2.2	1.7	2.0	1.5
Health satisfaction	1.5	1.9	4.3	0.7	1.0	2.1	2.0	1.0	0.8	1.5	1.6	-1.7	0.8	-0.2	2.0	1.4	0.2	1.2	1.9	1.1	1.7	1.4
Long-standing illness, disability or infirmity	1.5	2.3	3.6	1.4	1.7	0.3	1.9	1.9	1.4	1.9	1.2	0.2	1.1	1.2	1.9	1.6	1.2	1.8	1.8	1.6	1.5	1.6
Medication: Aspirin	1.5	1.9	4.2	1.1	1.4	1.1	2.1	1.6	1.0	1.3	1.6	-0.6	1.2	0.5	2.0	1.5	0.8	1.1	1.8	1.3	1.6	1.5
Smoking status: Current	1.5	2.3	5.9	1.4	1.4	2.4	1.4	1.2	1.4	1.6	2.0	-0.4	1.6	0.7	1.7	1.4	0.9	1.5	1.8	1.3	1.9	1.7
Illnesses of mother	1.4	1.8	3.3	-1.3	-1.4	-0.9	-1.8	-1.5	-1.3	-1.1	-1.4	-0.0	-1.1	-1.0	-1.7	-1.5	-1.0	-1.3	-1.6	-1.5	-1.5	-1.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.3	-1.3	-1.5	0.2	-1.7	-1.8	-1.2	-1.5	-1.0	-0.5	-1.0	-1.2	-1.6	-1.4	-1.2	-1.4	-1.4	-1.5	-1.2	-1.3
Eye problems/disorders: Glaucoma	1.4	1.7	3.3	-1.2	-1.4	-1.3	-1.7	-1.3	-1.2	-0.6	-1.2	-0.4	-0.8	-1.1	-1.8	-1.5	-1.1	-1.2	-1.6	-1.5	-1.6	-1.4
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.9	1.3	1.1	1.7	0.9	0.7	1.5	2.0	1.4	0.7	1.3	1.2	1.2	1.2	1.5	1.8	1.4	1.1	1.6	1.4
Vitamin and mineral supplements	1.3	1.7	2.6	-1.5	-1.1	-1.1	-1.5	-1.6	-1.4	-0.8	-1.2	-0.4	-1.6	-1.1	-1.3	-1.1	-1.1	-1.6	-1.4	-1.6	-1.4	-1.6
Fed-up feelings	1.3	2.4	7.1	-1.5	-1.9	1.2	-1.8	-2.7	-1.5	-1.3	-1.1	-0.9	-1.5	-1.7	-1.6	-1.4	-1.4	-1.4	-1.3	-1.7	-1.0	-1.5
Qualifications: CSEs or equivalent	1.3	1.8	4.8	1.4	1.2	2.2	1.0	0.6	1.3	0.3	1.0	1.7	0.9	1.5	1.1	1.4	1.6	1.2	1.3	1.5	1.6	1.3
Alcohol intake versus 10 years previously	1.3	2.0	3.3	1.6	1.7	0.1	1.2	1.8	1.6	1.3	1.3	1.2	1.4	1.7	1.2	1.4	1.4	1.4	1.2	1.5	1.1	1.5
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.7	1.4	1.5	0.5	0.6	1.1	1.5	1.3	1.1	2.2	1.1	1.8	0.6	1.5	1.8	1.2	0.9	1.3	0.9	1.0
Ever depressed for a whole week	1.3	1.6	3.4	-1.2	-1.4	0.3	-1.8	-1.8	-1.1	-1.2	-0.8	-0.6	-0.7	-1.2	-1.6	-1.5	-1.2	-1.3	-1.4	-1.5	-1.2	-1.2
Breast Cancer	1.2	2.9	8.4	1.2	1.7	0.3	2.9	2.2	1.1	1.7	1.4	-1.0	0.8	0.6	2.7	1.9	0.9	1.6	2.2	1.8	1.9	1.6
Blood White Count	1.2	8.7	17.4	-2.5	-2.6	-2.2	-3.8	-2.4	-2.8	-4.2	-2.6	-0.0	-1.4	-2.0	-3.7	-3.4	-2.5	-3.8	-3.6	-3.0	-3.5	-2.9
Gout (self-reported)	1.2	1.7	3.3	-0.9	-1.0	-1.7	-1.7	-0.8	-1.0	-1.8	-1.2	0.1	-0.6	-0.5	-1.7	-1.5	-1.1	-1.6	-1.7	-1.2	-1.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.1	-1.2	-1.6	-0.8	-1.8	-1.6	-1.0	-0.9	-1.1	-0.5	-0.9	-1.1	-1.5	-1.6	-1.1	-1.0	-1.5	-1.5	-1.3	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	6.5	1.0	1.5	1.0	2.5	1.5	0.8	0.7	1.1	-0.8	0.2	0.5	2.3	1.8	0.6	1.1	2.0	1.6	1.7	1.4
Height	1.1	21.8	50.4	5.5	4.5	5.1	1.5	3.2	5.5	2.6	5.1	7.1	6.0	6.2	2.1	4.2	6.0	3.8	3.1	4.5	3.8	4.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.8	-1.2	-1.5	-0.6	-2.4	-1.7	-1.3	-2.3	-1.4	0.6	-0.6	-0.8	-2.3	-1.8	-1.1	-1.8	-2.0	-1.6	-1.8	-1.5
Mouth/teeth dental problems	1.1	1.7	4.1	-0.9	-1.1	-1.4	-2.0	-1.1	-1.0	-1.2	-1.1	0.7	-0.5	-0.4	-1.9	-1.5	-0.6	-1.4	-1.8	-1.4	-1.7	-1.3
Time employed in main current job	1.1	1.3	3.5	1.3	0.9	0.4	0.3	0.7	1.4	1.5	0.8	1.9	1.2	1.6	0.3	0.8	1.7	1.5	0.6	1.0	0.8	1.0
Glaucoma (self-reported)	1.1	1.3	2.2	-1.1	-1.3	-0.7	-1.4	-1.4	-1.1	-0.4	-1.1	-0.4	-1.0	-1.0	-1.5	-1.2	-0.9	-0.9	-1.3	-1.4	-1.2	-1.3
Loneliness, isolation	1.1	1.5	4.8	-1.1	-1.4	2.1	-0.8	-2.2	-1.0	-0.5	-0.2	-1.9	-1.3	-1.7	-0.4	-0.7	-1.4	-0.7	-0.3	-1.1	-0.0	-0.8
Back pain experienced in last month	1.1	1.6	2.4	1.3	1.4	1.0	1.0	1.1	1.5	1.4	1.1	1.0	1.0	1.4	1.2	1.4	1.4	1.5	1.3	1.3	1.4	1.3
Wears glasses or contact lenses	1.1	1.3	2.0	1.3	1.1	1.1	1.3	1.2	1.2	0.5	0.9	0.6	1.1	1.1	1.1	1.0	0.9	1.3	1.2	1.4	1.2	1.4
Major Depression (MDD)	1.0	1.2	4.0	-0.8	-1.1	0.1	-1.2	-1.3	-1.1	-2.0	-1.0	-0.1	-0.7	-0.8	-1.2	-1.2	-1.0	-1.4	-1.1	-0.9	-0.9	-1.0
Age at First Birth	1.0	1.4	3.1	-0.9	-1.1	-1.4	-1.7	-0.9	-0.9	-1.5	-1.2	0.9	-0.5	-0.3	-1.8	-1.3	-0.6	-1.3	-1.6	-1.0	-1.5	-1.2
Frequency of depressed mood in last 2 weeks	1.0	1.5	3.1	-1.4	-1.3	-0.3	-0.7	-1.6	-1.3	-0.8	-1.1	-1.7	-1.8	-1.6	-0.6	-1.0	-1.5	-1.1	-0.8	-1.3	-0.8	-1.2
Hearing difficulty/problems: Yes	1.0	1.5	5.1	0.8	1.4	-0.5	2.3	2.0	0.7	0.6	0.5	-0.2	0.4	0.7	1.9	1.4	0.7	1.0	1.5	1.5	1.1	1.1
Fluid intelligence score	1.0	2.1	7.8	0.7	1.6	-0.2	2.8	1.9	0.7	1.1	0.7	-1.3	-0.1	0.3	2.6	1.7	0.4	1.2	2.0	1.5	1.5	1.2
Worry too long after embarrassment	1.0	1.7	4.3	-1.2	-1.5	-0.0	-2.1	-1.9	-1.0	-0.9	-0.8	0.1	-0.9	-0.9	-1.8	-1.3	-0.9	-1.3	-1.6	-1.5	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	7.6	0.7	0.7	2.7	0.8	0.1	0.7	1.1	1.3	-0.4	0.8	0.1	1.1	1.0	0.6	1.0	1.3	0.7	1.5	1.0
Systolic Blood Pressure	0.9	4.5	10.9	2.2	1.6	3.3	1.8	1.9	2.0	1.9	2.6	0.1	3.1	1.3	1.9	1.5	1.7	2.3	2.2	1.9	2.4	2.5
Exposure to tobacco smoke at home	0.9	1.1	1.5	1.1	1.0	0.7	0.9	0.9	1.2	0.9	0.9	1.0	0.8	1.2	1.0	1.1	1.2	1.2	1.0	1.2	1.1	1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	4.0	-0.6	-1.0	-0.0	-2.0	-1.8	-0.4	-0.1	-0.7	1.1	-0.8	-0.1	-1.7	-0.9	-0.1	-0.6	-1.3	-1.1	-1.0	-1.1
Average weekly beer plus cider intake	0.9	1.3	2.1	-1.2	-1.0	-1.1	-1.1	-1.0	-1.2	-1.3	-0.9	-0.9	-1.3	-1.1	-1.0	-1.0	-1.4	-1.4	-1.1	-1.2	-1.2	-1.2
Schizophrenia vs Biploar Disorder	0.8	1.1	1.6	-1.2	-1.0	-0.8	-0.8	-1.0	-1.2	-1.0	-1.2	-0.9	-1.3	-1.1	-0.8	-1.0	-1.2	-1.0	-0.9	-1.0	-1.0	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	3.6	-0.7	-1.1	1.7	-1.3	-1.9	-0.6	-1.3	-0.4	0.2	-0.7	-0.7	-0.9	-0.7	-0.5	-1.0	-0.7	-0.8	-0.3	-0.8
Qualifications: None of the above	0.8	1.6	4.9	0.9	1.0	2.2	1.4	0.8	1.0	1.4	1.6	-0.8	0.9	0.2	1.6	1.4	0.6	1.2	1.6	1.0	1.6	1.3
Pulse rate	0.8	1.4	5.9	1.4	1.0	0.3	0.0	1.0	1.5	0.6	1.0	2.4	1.6	1.9	0.1	0.8	1.6	1.0	0.4	1.1	0.5	1.0
Loud music exposure frequency	0.8	0.8	5.8	-0.8	-0.2	-0.5	1.2	0.0	-0.8	-0.2	-0.6	-2.4	-1.4	-1.3	1.1	0.1	-1.2	-0.2	0.5	-0.1	0.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.0	1.1	1.0	1.0	0.9	0.8	1.2	0.2	0.8	1.4	0.8	1.3	0.9	1.2	1.2	0.9	0.9	1.3	1.1	1.0
Comparative height size at age 10	0.8	4.5	9.7	2.5	1.9	2.2	0.4	1.6	2.6	2.6	2.7	2.1	3.1	2.5	1.0	1.5	2.5	2.2	1.5	1.6	1.8	2.2
Friendships satisfaction	0.8	1.0	2.2	-0.8	-0.9	-0.9	-1.4	-0.9	-0.8	-1.5	-1.0	0.6	-0.6	-0.4	-1.4	-1.0	-0.6	-1.2	-1.3	-0.9	-1.2	-1.1
Guilty feelings	0.8	1.2	3.9	-1.2	-1.4	1.0	-1.2	-2.0	-1.0	-0.7	-0.8	-0.8	-1.1	-1.3	-1.0	-1.0	-0.9	-0.8	-0.9	-1.2	-0.6	-1.1
Hearing aid user	0.8	0.9	4.3	0.2	0.5	0.5	2.1	0.9	0.1	0.5	0.3	-1.7	-0.3	-0.5	1.7	0.9	-0.1	0.8	1.3	0.9	1.2	0.8
Financial situation satisfaction	0.8	1.0	3.3	0.7	0.7	1.8	1.1	0.6	0.8	0.7	1.4	-0.4	0.9	0.2	1.2	1.1	0.5	0.7	1.2	0.8	1.2	1.0
Age when periods started (menarche)	0.7	1.7	6.0	-0.3	-0.6	-1.0	-2.1	-1.1	-0.4	-1.9	-1.1	2.4	-0.4	0.7	-1.9	-1.1	0.1	-1.3	-1.6	-0.8	-1.4	-1.1
Serious illness, injury or assault to yourself	0.7	0.8	2.6	0.7	0.7	1.5	0.6	0.3	0.9	1.6	1.2	-0.4	0.7	0.4	0.9	0.8	0.5	1.1	1.0	0.5	1.1	0.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.8	-0.3	-0.6	-2.2	-2.0	-0.4	-0.2	-1.1	-0.9	1.9	0.1	0.6	-1.9	-1.2	-0.1	-0.9	-1.7	-0.8	-1.7	-0.9
Number of children fathered	0.7	0.8	2.9	-1.0	-0.7	-0.0	0.3	-0.4	-1.2	-1.4	-0.7	-1.7	-1.0	-1.4	0.1	-0.6	-1.3	-1.2	-0.2	-0.6	-0.4	-0.6
Medication: Omeprazole	0.7	0.8	2.3	1.0	0.7	0.7	-0.3	0.5	1.2	1.1	1.0	1.3	1.5	1.2	0.1	0.3	1.0	0.9	0.4	0.5	0.5	0.9
Average weekly red wine intake	0.7	1.1	1.9	-1.2	-0.9	-1.4	-0.4	-0.6	-1.2	-0.9	-1.1	-1.2	-1.2	-1.2	-0.7	-0.9	-1.3	-1.1	-0.9	-1.0	-1.1	-1.0
Commuting to job workplace: Walk	0.7	0.8	3.3	-0.1	-0.4	-0.4	-1.7	-0.8	-0.0	-0.8	-0.7	1.8	0.0	0.6	-1.5	-0.8	0.3	-0.5	-1.1	-0.5	-0.9	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.4	0.6	0.8	0.3	1.2	1.1	0.7	1.2	0.8	-0.5	0.6	0.3	1.2	0.9	0.4	0.9	1.0	0.8	0.9	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	6.0	-0.9	-0.6	1.1	0.5	-0.9	-0.8	0.4	-0.1	-2.5	-1.2	-1.5	0.7	-0.1	-1.0	-0.2	0.5	-0.6	0.4	-0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	1.0	0.9	0.3	0.5	0.6	1.0	0.7	0.5	1.3	0.7	1.2	0.6	0.7	1.1	0.8	0.6	0.8	0.7	0.7
Shortness of breath walking on level ground	0.6	0.8	3.6	-0.3	0.2	1.1	1.6	0.0	-0.2	0.5	0.2	-1.9	-0.8	-0.9	1.4	0.7	-0.5	0.4	1.1	0.3	1.0	0.3
Family relationship satisfaction	0.6	0.8	3.6	1.0	1.0	-0.3	0.1	0.9	1.1	0.3	0.6	1.9	1.0	1.5	0.2	0.7	1.2	0.5	0.3	0.8	0.3	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	5.4	-0.6	-0.3	-2.3	-0.5	0.2	-0.6	-0.8	-1.0	0.4	-0.6	-0.1	-0.9	-0.6	-0.4	-0.8	-1.0	-0.5	-1.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	-0.8	-0.9	-0.4	-0.8	-0.8	-0.8	-0.7	-0.7	-0.9	-0.6	-0.9	-0.7	-0.9	-1.0	-0.7	-0.7	-0.9	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.3	0.6	0.8	1.5	1.4	0.7	0.4	-0.3	0.8	-0.3	0.4	0.1	1.1	1.1	0.2	0.3	1.1	1.0	1.1	0.8
Mean Putamen Volume	0.5	0.6	3.1	-0.4	-0.6	-0.3	-0.9	-0.7	-0.5	-1.8	-0.9	0.8	-0.5	-0.1	-1.1	-0.6	-0.5	-0.9	-0.9	-0.3	-0.8	-0.6
Fasting Glucose	0.5	0.6	1.7	0.9	0.8	1.3	1.0	0.8	0.7	-0.4	0.9	-0.0	0.9	0.5	0.9	0.8	0.1	0.4	0.9	1.0	0.9	0.6
Allergy or Eczema	0.5	1.4	6.7	-0.2	-0.4	-2.6	-1.8	0.0	-0.1	-1.0	-0.8	1.8	0.3	0.7	-1.7	-1.1	-0.1	-0.9	-1.6	-0.7	-1.7	-0.7
Hypothyroidism (self reported)	0.5	1.2	2.7	-0.9	-1.4	-0.5	-1.6	-1.5	-0.8	-0.6	-0.9	-0.3	-0.8	-0.8	-1.4	-1.4	-0.9	-0.8	-1.3	-1.3	-1.1	-1.1
Average weekly spirits intake	0.5	0.7	1.4	0.9	0.9	0.9	0.6	0.8	0.9	0.9	1.2	0.4	1.1	0.7	0.7	0.9	0.7	0.7	0.8	0.7	0.8	0.9
Alcohol usually taken with meals	0.5	0.8	3.7	-0.8	-0.6	-1.9	-0.6	-0.4	-0.8	-0.6	-1.5	-0.0	-1.1	-0.4	-0.9	-0.9	-0.6	-0.6	-1.0	-0.7	-1.1	-0.9
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	-0.7	-0.8	-1.3	-0.5	-0.5	-0.7	-0.9	-0.8	-0.2	-0.8	-0.5	-0.8	-0.6	-0.7	-0.8	-0.9	-0.6	-1.0	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	-0.7	-1.0	0.7	-1.1	-1.4	-0.6	-0.0	-0.2	-1.0	-0.6	-0.9	-0.7	-0.9	-0.9	-0.5	-0.6	-1.1	-0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.7	0.3	0.4	1.7	1.1	0.1	0.4	1.0	0.6	-1.4	0.1	-0.3	1.2	0.5	0.0	0.9	1.2	0.5	1.2	0.7
Standing height	0.5	5.0	22.2	2.7	1.7	2.1	-0.9	0.7	2.7	1.4	2.2	4.7	3.0	3.5	-0.2	1.2	3.1	1.6	0.6	1.5	1.1	1.7
Commuting to job workplace: Public transport	0.5	0.5	0.9	0.8	0.8	0.4	0.6	0.6	0.8	0.8	0.6	0.9	0.4	0.9	0.6	0.9	1.0	0.8	0.7	0.8	0.7	0.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	0.2	1.0	-0.7	1.9	1.3	0.2	0.6	0.2	-1.3	-0.4	-0.0	1.7	0.9	-0.1	0.7	1.2	0.8	0.8	0.7
Ovarian Cancer	0.4	0.6	1.4	-0.3	-0.5	-1.1	-1.2	-0.7	-0.3	-0.6	-0.7	1.0	-0.5	0.2	-1.1	-0.6	-0.1	-0.7	-1.0	-0.6	-1.0	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.9	-0.7	-0.9	-0.2	-1.2	-1.0	-0.8	-1.4	-0.8	0.0	-0.5	-0.6	-1.2	-1.0	-0.8	-1.1	-1.1	-0.9	-1.0	-0.9
Multivitamins +/- minerals	0.4	0.5	1.0	0.8	0.6	0.8	0.8	0.8	0.7	-0.3	0.6	0.5	1.0	0.6	0.6	0.5	0.6	0.5	0.6	0.9	0.7	0.9
Supplements: Glucosamine	0.4	0.6	1.6	-0.7	-0.6	-1.3	-0.5	-0.1	-0.9	-0.7	-0.7	-0.4	-0.3	-0.6	-0.7	-0.8	-0.7	-0.9	-0.8	-0.7	-1.0	-0.7
Allergy	0.4	0.9	6.0	-0.7	-0.9	1.6	0.3	-1.0	-0.7	0.4	0.1	-2.4	-0.6	-1.6	0.4	-0.3	-1.1	-0.0	0.3	-0.6	0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	0.6	0.8	0.1	0.7	0.5	0.7	0.7	0.4	0.8	-0.1	0.9	0.7	1.1	0.8	0.7	0.7	0.8	0.6	0.5
Medication: Lansoprazole	0.4	0.5	1.7	0.1	0.4	-0.2	1.3	0.7	0.2	1.0	0.2	-1.2	-0.2	-0.3	1.2	0.6	-0.1	0.7	0.9	0.5	0.7	0.5
Prospective memory result	0.4	0.5	2.2	-0.2	-0.9	0.5	-1.5	-1.0	-0.1	0.5	-0.0	-0.1	0.6	-0.3	-1.1	-1.2	-0.3	0.0	-0.8	-0.9	-0.5	-0.3
Peak expiratory flow (PEF)	0.4	1.0	3.1	-0.9	-1.2	1.4	-1.3	-1.8	-0.9	-0.8	-0.4	-0.5	-0.6	-1.1	-1.1	-0.9	-0.8	-1.0	-0.8	-1.1	-0.5	-0.9
Medication: Ibuprofen	0.4	0.4	1.3	0.5	0.9	0.4	0.4	0.3	0.7	0.5	0.5	1.1	-0.1	0.9	0.5	1.1	0.9	0.4	0.5	0.7	0.5	0.4
Qualifications: nursing, teaching	0.4	0.7	3.1	-0.3	-0.4	-1.8	-1.2	0.0	-0.4	-0.6	-0.7	0.5	0.2	0.1	-1.1	-1.1	-0.4	-0.7	-1.1	-0.7	-1.2	-0.5
Eye problems/disorders: Cataract	0.4	0.5	1.6	0.7	0.8	0.1	0.4	0.6	0.8	1.2	0.6	0.6	0.4	0.9	0.6	0.8	0.8	1.0	0.6	0.6	0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.7	0.2	-0.0	0.8	0.1	0.1	0.6	1.6	0.8	-1.2	0.7	-0.2	0.4	-0.0	-0.1	1.0	0.5	-0.1	0.6	0.6
Osteoarthritis (self-reported)	0.4	0.5	2.5	0.8	0.4	-0.0	-0.2	0.5	1.0	1.6	0.7	0.8	1.1	1.0	0.0	0.2	0.9	1.1	0.2	0.3	0.3	0.6
Mother’s age at death	0.4	0.5	2.8	-0.6	-0.7	-1.7	-0.3	-0.2	-0.5	-0.6	-0.9	-0.3	-0.7	-0.4	-0.6	-0.7	-0.7	-0.5	-0.8	-0.5	-0.9	-0.6
Risk taking	0.4	0.5	2.1	0.5	0.7	-0.3	1.4	1.1	0.5	0.6	0.6	-0.5	0.3	0.2	1.2	0.8	0.3	0.6	0.9	0.8	0.7	0.7
Bipolar Disorder (2018)	0.3	0.4	1.5	0.7	0.8	-0.5	0.3	0.9	0.7	0.1	0.3	1.2	0.7	1.0	0.2	0.5	0.7	0.3	0.2	0.7	0.2	0.6
Schizophrenia (2018)	0.3	0.5	3.7	-0.2	-0.3	-1.9	-0.8	-0.2	-0.1	-0.2	-1.0	1.0	-0.5	0.5	-0.8	-0.7	0.0	-0.2	-0.8	-0.3	-0.8	-0.5
Crohns Disease (2017)	0.3	0.7	2.0	-0.7	-1.2	1.2	-0.9	-1.4	-0.5	0.3	-0.0	-1.3	-0.2	-1.2	-0.6	-1.0	-0.9	-0.2	-0.4	-1.0	-0.2	-0.5
Schizophrenia (2014)	0.3	0.7	3.2	-0.2	-0.3	-1.8	-1.0	-0.3	-0.2	-0.9	-1.2	1.5	-0.5	0.6	-1.1	-0.8	0.1	-0.5	-1.0	-0.3	-1.0	-0.7
Waist Hip Ratio (WHR)	0.3	1.2	6.6	0.2	-0.6	-0.2	-2.6	-1.0	0.4	0.3	0.1	1.9	0.9	0.8	-1.9	-1.1	0.4	-0.2	-1.4	-0.9	-1.0	-0.5
Diabetes (father)	0.3	0.3	1.7	0.4	0.1	0.0	-0.8	0.2	0.3	-0.2	0.4	1.3	1.1	0.6	-0.9	-0.2	0.5	-0.2	-0.5	-0.0	-0.4	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.4	0.5	0.5	0.8	0.5	0.5	0.6	0.6	-0.3	0.3	0.2	0.9	0.6	0.3	0.6	0.8	0.5	0.7	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.6	0.8	0.8	-0.5	0.8	1.3	0.8	0.0	0.5	0.7	0.9	0.9	0.6	0.6	0.6	0.5	0.5	0.9	0.4	0.8
Heart attack	0.3	0.4	1.0	0.6	0.8	0.3	0.9	1.0	0.5	0.1	0.7	-0.1	0.6	0.4	1.0	0.6	0.3	0.3	0.8	0.7	0.7	0.7
Lung cancer (father)	0.3	0.4	1.9	-0.1	-0.3	0.9	-1.2	-1.4	0.1	0.4	-0.2	1.1	-0.4	0.4	-0.7	-0.3	0.4	-0.0	-0.4	-0.5	-0.1	-0.4
Blood clot in the leg (DVT)	0.3	0.4	1.7	-0.6	-0.0	-1.3	0.8	0.2	-0.7	-0.6	-0.7	-0.8	-1.2	-0.6	0.5	0.2	-0.6	-0.6	0.1	-0.0	-0.3	-0.4
Angina (self-reported)	0.3	0.3	2.2	-0.2	-0.1	1.5	0.7	-0.2	-0.2	-0.0	0.1	-1.2	-0.1	-0.7	0.7	0.1	-0.3	0.2	0.7	0.1	0.8	0.3
Migraine (self-reported)	0.3	0.3	1.2	0.1	0.2	-0.0	1.1	0.7	0.2	0.7	0.3	-1.0	0.3	-0.3	0.8	0.3	-0.1	0.7	0.7	0.4	0.6	0.5
Leg pain on walking	0.3	0.4	2.4	-0.2	-0.6	1.6	0.3	-0.6	-0.2	0.4	0.3	-1.4	0.1	-0.9	0.2	-0.2	-0.5	0.3	0.3	-0.1	0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	3.0	-0.2	-0.3	1.0	0.7	0.0	-0.4	0.2	0.5	-1.7	0.3	-1.0	0.5	-0.1	-0.6	-0.0	0.4	-0.1	0.4	0.2
Breast cancer (self-reported)	0.3	0.3	1.2	-0.2	-0.5	-1.1	-0.7	-0.4	-0.2	-0.3	-0.7	0.9	-0.1	0.2	-0.9	-0.6	0.1	-0.2	-0.8	-0.3	-0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	0.6	0.4	-0.1	-0.3	0.4	0.7	0.9	0.4	1.0	0.8	0.9	0.0	0.1	0.8	0.7	0.1	0.2	0.2	0.5
Supplements: Calcium	0.3	0.4	0.7	0.6	0.6	0.2	0.5	0.8	0.7	0.7	0.5	0.1	0.8	0.6	0.6	0.4	0.5	0.8	0.6	0.6	0.5	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	-0.4	-0.7	-0.7	-0.9	-0.4	-0.4	-0.7	-0.5	-0.1	-0.0	-0.4	-0.9	-0.9	-0.6	-0.6	-0.9	-0.6	-0.8	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	0.5	0.8	0.4	0.8	0.9	0.4	-0.0	0.6	-0.0	0.6	0.4	0.9	0.5	0.3	0.2	0.7	0.6	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.3	-0.5	0.1	-1.2	0.8	0.3	-0.6	-0.5	-0.5	-0.9	-0.9	-0.5	0.5	0.2	-0.5	-0.5	0.1	0.0	-0.2	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	3.2	0.3	0.3	-1.8	-0.4	0.4	0.4	-0.1	-0.6	1.6	0.1	1.0	-0.5	-0.2	0.5	0.1	-0.5	0.2	-0.6	-0.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.7	-0.4	-0.9	1.3	-0.7	-1.2	-0.2	0.5	0.1	-0.7	-0.1	-0.7	-0.4	-0.5	-0.3	0.1	-0.2	-0.7	0.1	-0.3
Crohns Disease (2012)	0.2	0.3	0.6	-0.6	-0.6	-0.0	-0.6	-0.7	-0.4	-0.2	-0.4	-0.8	-0.5	-0.7	-0.5	-0.6	-0.7	-0.3	-0.4	-0.6	-0.4	-0.4
Lupus	0.2	0.3	1.8	0.3	0.1	-0.1	-1.1	-0.6	0.6	0.1	0.0	1.4	0.0	0.9	-0.5	-0.2	0.4	0.1	-0.3	-0.2	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.3	-0.3	-0.2	-0.5	-0.3	-0.3	-0.8	-0.5	0.5	-0.2	-0.0	-0.6	-0.4	-0.2	-0.5	-0.5	-0.3	-0.5	-0.4
Ulcerative Colitis	0.2	0.3	1.8	-0.5	-0.4	0.1	0.3	-0.5	-0.4	0.3	-0.3	-1.3	-0.9	-0.8	0.3	-0.0	-0.6	-0.0	0.2	-0.3	0.1	-0.3
Blood Platelet Count	0.2	2.1	9.4	-1.8	-0.6	-1.3	0.7	-0.4	-1.8	-1.0	-1.3	-3.1	-2.2	-2.2	0.4	-0.6	-2.1	-1.3	-0.2	-1.0	-0.7	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.5	0.3	0.4	-0.1	0.6	0.4	0.4	1.2	0.3	-0.5	0.1	0.2	0.7	0.4	0.2	0.8	0.6	0.3	0.5	0.4
Angina	0.2	0.3	2.3	-0.1	-0.2	1.5	0.6	-0.3	-0.2	0.0	0.1	-1.1	-0.1	-0.7	0.7	0.1	-0.3	0.2	0.6	0.1	0.7	0.3
Stomach or abdominal pain in last month	0.2	0.2	1.3	-0.6	-0.3	-0.6	0.0	-0.1	-0.5	0.4	-0.3	-1.1	-0.5	-0.7	0.0	-0.4	-0.6	-0.2	-0.1	-0.5	-0.3	-0.3
Medication: Atenolol	0.2	0.3	1.9	-0.1	-0.2	1.4	0.3	-0.4	-0.2	0.1	0.5	-1.4	-0.1	-0.7	0.5	0.1	-0.5	-0.1	0.4	-0.1	0.5	0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.9	0.1	0.1	0.8	0.7	0.2	0.1	1.1	0.4	-1.4	0.2	-0.4	0.8	0.2	-0.2	0.7	0.7	0.1	0.7	0.4
Depression (self-reported)	0.2	0.3	1.3	-0.5	-0.7	-0.3	-0.0	-0.3	-0.4	-0.4	-0.2	-1.1	-0.4	-0.8	-0.1	-0.5	-0.8	-0.3	-0.3	-0.4	-0.3	-0.3
Length of working week for main job	0.2	0.2	0.7	-0.5	-0.4	-0.3	-0.5	-0.4	-0.4	-0.8	-0.3	-0.1	-0.3	-0.4	-0.6	-0.4	-0.5	-0.7	-0.6	-0.4	-0.6	-0.5
Hair/balding pattern: Pattern 4	0.2	0.4	3.2	-0.4	-0.5	0.6	-0.1	-0.4	-0.4	1.1	0.2	-1.8	0.0	-1.0	0.1	-0.5	-0.7	0.2	0.1	-0.7	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	2.1	0.1	0.1	-1.4	-0.5	0.2	0.1	-0.1	-0.6	1.3	-0.1	0.7	-0.5	-0.1	0.5	0.0	-0.5	0.0	-0.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.3	-0.4	-0.3	-0.6	-0.2	-0.3	-0.6	-0.2	0.4	0.2	-0.2	-0.7	-0.4	-0.1	-0.5	-0.6	-0.4	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.4	0.0	-0.3	-0.3	-1.2	-0.2	0.1	0.6	0.0	0.8	0.7	0.3	-0.9	-0.5	0.3	0.1	-0.7	-0.5	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-0.4	-0.7	-0.0	-1.1	-1.1	-0.3	-0.5	-0.5	0.5	-0.5	-0.1	-0.9	-0.6	-0.2	-0.5	-0.7	-0.6	-0.5	-0.6
Ever had bowel cancer screening	0.2	0.2	1.2	-0.4	-0.4	0.3	0.3	-0.2	-0.5	-1.1	-0.2	-0.9	-0.2	-0.8	0.2	-0.3	-0.7	-0.6	-0.0	-0.2	-0.1	-0.2
Mineral and other dietary supplements	0.2	0.2	0.5	0.2	0.5	0.7	0.6	-0.0	0.3	0.6	0.3	0.0	-0.3	0.2	0.7	0.7	0.4	0.5	0.7	0.4	0.7	0.3
Average weekly champagne plus white wine intake	0.2	0.3	1.7	-0.4	-0.0	-0.2	0.9	0.1	-0.5	-0.4	-0.4	-1.3	-0.9	-0.7	0.6	0.2	-0.7	-0.2	0.4	0.0	0.2	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.4	0.3	0.7	0.8	0.4	0.3	0.3	0.5	-0.5	0.3	0.0	0.6	0.5	0.1	0.5	0.6	0.5	0.6	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.3	-0.5	0.4	-0.6	-0.7	-0.4	-0.4	-0.1	-0.4	-0.2	-0.5	-0.5	-0.5	-0.6	-0.5	-0.4	-0.6	-0.3	-0.3
Age started oral contraceptive pill	0.2	0.3	1.0	0.6	0.4	-0.2	-0.0	0.4	0.6	0.6	0.3	1.0	0.5	0.9	0.1	0.3	0.7	0.5	0.1	0.4	0.2	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	4.0	-0.2	0.4	-2.0	0.7	0.8	-0.2	0.1	-0.6	-0.6	-0.8	-0.0	0.5	0.2	-0.2	-0.1	0.1	0.1	-0.3	-0.1
Reaction Time	0.1	0.3	1.1	0.2	0.5	-0.8	0.7	0.4	0.3	1.0	-0.2	-0.0	-0.5	0.3	0.7	0.5	0.4	0.8	0.5	0.4	0.4	0.2
Prostate Cancer	0.1	0.2	0.8	0.5	0.0	0.3	-0.2	0.2	0.5	0.6	0.5	0.3	0.9	0.4	-0.1	-0.1	0.3	0.5	0.0	0.1	0.1	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.8	-0.7	-0.3	-0.2	-0.1	-0.6	-0.2	-0.2	-0.6	-0.1	-0.9	-0.3	-0.2	-0.0	-0.3	-0.1	-0.2	-0.2	-0.2	-0.1
HbA1C	0.1	0.1	0.4	0.0	0.3	-0.6	0.2	0.5	0.1	-0.2	0.1	0.0	0.3	0.2	-0.1	0.1	-0.2	-0.1	-0.1	0.2	-0.2	-0.1
Rheumatoid Arthritis	0.1	0.2	0.6	0.4	-0.0	0.8	-0.3	-0.2	0.5	0.8	0.5	0.0	0.4	0.3	0.0	-0.0	0.2	0.6	0.2	0.0	0.4	0.4
Chronotype (morning person)	0.1	0.2	1.8	-0.2	-0.3	1.3	0.2	-0.4	-0.2	0.0	0.2	-0.7	-0.0	-0.6	0.1	0.0	-0.2	0.0	0.2	-0.1	0.4	0.0
Hair Pigment	0.1	3.2	4.7	-1.9	-1.8	-2.2	-1.8	-1.6	-1.8	-1.4	-1.9	-0.6	-1.9	-1.5	-2.0	-1.7	-1.6	-1.8	-2.0	-1.8	-2.1	-2.0
Tanning	0.1	1.6	3.3	-1.1	-1.0	-1.8	-1.5	-1.1	-1.1	-1.6	-1.3	0.2	-1.3	-0.6	-1.4	-1.2	-1.0	-1.6	-1.5	-1.2	-1.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	0.3	0.3	0.6	-0.1	0.3	0.4	0.6	0.7	-0.4	0.7	0.1	0.1	0.1	-0.1	0.4	0.3	0.1	0.2	0.5
Supplements: Zinc	0.1	0.1	0.3	0.0	-0.4	-0.2	-0.6	-0.3	-0.1	0.1	-0.3	0.3	0.2	0.0	-0.5	-0.5	0.1	0.1	-0.4	-0.3	-0.3	-0.2
Severe depression (siblings)	0.1	0.1	1.0	-0.1	-0.1	-0.5	-0.4	-0.2	0.1	1.0	0.1	-0.1	0.0	0.0	-0.3	-0.2	0.0	0.2	-0.2	-0.4	-0.2	-0.2
Average weekly fortified wine intake	0.1	0.1	0.7	0.2	0.1	-0.9	-0.1	0.4	0.1	-0.2	-0.2	0.7	0.3	0.4	-0.3	-0.2	0.2	-0.0	-0.3	0.1	-0.3	0.0
Maternal smoking around birth	0.1	0.2	1.2	0.2	0.2	1.1	0.4	0.3	0.2	-0.4	0.8	-0.4	0.4	-0.2	0.3	0.5	-0.2	-0.1	0.4	0.3	0.4	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.4	0.1	-0.3	0.1	-0.6	-0.4	0.2	0.1	0.0	0.6	0.2	0.3	-0.4	-0.3	0.2	0.1	-0.3	-0.2	-0.2	-0.0
Sitting height	0.1	1.0	2.4	-0.9	-1.2	1.0	-1.1	-1.5	-0.8	-0.4	-0.1	-1.4	-0.6	-1.3	-0.8	-0.9	-1.2	-0.9	-0.7	-1.2	-0.5	-0.7
Number of live births	0.1	0.2	2.0	-0.2	-0.2	1.4	0.1	-0.7	-0.2	-0.7	-0.1	-0.0	-0.5	-0.3	0.2	0.2	-0.1	-0.2	0.2	0.1	0.4	-0.1
Noisy workplace	0.1	0.1	0.5	-0.3	-0.4	0.7	-0.2	-0.6	-0.2	0.4	0.1	-0.7	-0.1	-0.5	-0.2	-0.3	-0.4	0.0	-0.1	-0.4	0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.9	-0.3	-0.7	-0.2	-1.0	-0.7	-0.2	-0.3	-0.3	0.2	-0.0	-0.2	-0.8	-0.8	-0.2	-0.3	-0.7	-0.6	-0.5	-0.4
Medication: Amlodipine	0.1	0.1	1.3	0.1	-0.0	1.1	0.0	-0.2	0.1	0.0	0.4	-0.1	0.2	-0.1	0.2	0.2	0.1	0.1	0.3	0.1	0.4	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.0	0.1	0.4	0.5	0.0	-0.1	-0.4	-0.0	-0.3	-0.1	-0.2	0.5	0.1	-0.1	-0.1	0.3	0.2	0.3	0.1
Medication: Seretide 50 evohaler	0.1	0.1	1.0	0.1	0.3	-1.0	0.2	0.5	0.2	0.6	0.1	0.2	0.1	0.4	0.2	0.2	0.2	0.2	0.1	0.1	-0.1	0.1
Mean time to correctly identify matches	0.1	0.2	1.8	-0.2	0.1	-1.4	0.5	0.2	-0.0	0.8	-0.6	-0.4	-0.8	-0.0	0.3	0.1	-0.1	0.4	0.1	0.0	-0.1	-0.1
Heart disease (mother)	0.1	0.1	1.3	-0.2	-0.3	0.1	0.3	0.0	-0.3	-0.1	-0.0	-1.1	-0.1	-0.6	0.2	-0.2	-0.6	-0.0	0.1	-0.1	0.0	0.0
Illnesses of father: Heart disease	0.1	0.2	1.1	-0.0	0.2	-0.2	0.9	0.6	-0.1	0.3	0.1	-1.1	0.1	-0.4	0.7	0.2	-0.2	0.2	0.5	0.2	0.3	0.2
Alcohol drinker status: Never	0.1	0.2	0.5	-0.5	-0.6	-0.4	-0.3	-0.7	-0.3	0.1	-0.6	-0.1	-0.7	-0.3	-0.2	-0.3	-0.2	-0.0	-0.3	-0.3	-0.2	-0.5
Commuting to job workplace: Cycle	0.1	0.1	1.1	0.1	0.4	-0.5	0.0	0.5	-0.1	-1.1	-0.0	0.5	0.1	0.3	-0.0	0.1	-0.1	-0.6	-0.1	0.2	-0.3	-0.0
Ulcerative Colitis (UC)	0.0	0.1	0.4	0.1	-0.1	0.6	-0.2	-0.4	0.2	0.6	0.2	0.1	0.1	0.0	-0.1	0.1	0.2	0.4	0.1	-0.0	0.2	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Medication for hormone replacement therapy	0.0	0.0	0.3	-0.2	0.1	-0.6	-0.0	0.1	-0.1	0.0	-0.2	-0.3	-0.2	-0.1	-0.1	-0.1	-0.3	-0.1	-0.1	-0.2	-0.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.3	0.0	-0.1	0.3	-0.5	-0.3	-0.0	-0.2	-0.0	0.4	0.2	0.1	-0.4	-0.3	0.1	-0.2	-0.2	-0.2	-0.1	-0.1
Supplements: Vitamin C	0.0	0.1	0.4	0.0	-0.1	-0.7	-0.2	0.2	0.0	0.2	-0.2	-0.2	0.1	0.0	-0.2	-0.3	-0.2	0.2	-0.2	-0.1	-0.2	-0.0

Hub : Genes

MYST1

Models

Trait associations