Best TWAS P=4.31e-18 · Best GWAS P=2.49e-34 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NELFCD | 0.43 | 0.31 | enet | 36 | 0.38 | 3.3e-33 | -4.9 | 5.8 | 8.2e-09 | 0.17 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Artery Aorta | NELFCD | 0.43 | 0.34 | lasso | 4 | 0.37 | 1.8e-21 | -4.9 | 5.3 | 1.4e-07 | 0.21 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Coronary | NELFCD | 0.36 | 0.20 | lasso | 7 | 0.22 | 6.5e-08 | -4.7 | 5.2 | 2.5e-07 | 0.13 | 0.85 | 0.02 | FALSE |
| 4 | GTEx | Artery Tibial | NELFCD | 0.24 | 0.16 | lasso | 4 | 0.16 | 1.2e-12 | -4.9 | 5.1 | 2.8e-07 | 0.25 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Breast Mammary Tissue | NELFCD | 0.40 | 0.20 | lasso | 7 | 0.19 | 4.1e-10 | -5.0 | 5.2 | 2.3e-07 | 0.19 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | NELFCD | 0.45 | 0.14 | lasso | 9 | 0.18 | 3.4e-07 | -5.2 | 5.1 | 2.7e-07 | 0.17 | 0.96 | 0.01 | FALSE |
| 7 | GTEx | Esophagus Mucosa | NELFCD | 0.32 | 0.20 | enet | 8 | 0.27 | 2.1e-18 | -4.7 | 5.9 | 3.7e-09 | 0.22 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | NELFCD | 0.23 | 0.15 | enet | 14 | 0.18 | 6.7e-11 | -4.9 | 5.4 | 6.6e-08 | 0.18 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Lung | NELFCD | 0.22 | 0.22 | lasso | 2 | 0.21 | 5.0e-16 | -4.9 | 5.1 | 2.8e-07 | 0.19 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | NELFCD | 0.30 | 0.17 | enet | 25 | 0.23 | 2.8e-16 | -4.9 | 6.1 | 8.3e-10 | 0.27 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | NELFCD | 0.28 | 0.21 | lasso | 7 | 0.22 | 1.1e-17 | -5.0 | 5.4 | 5.7e-08 | 0.18 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | TH1L | 0.08 | 0.05 | lasso | 3 | 0.07 | 8.1e-05 | -4.7 | 5.7 | 1.3e-08 | 0.14 | 0.01 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TH1L | 0.07 | 0.00 | blup | 46 | 0.02 | 2.8e-02 | -4.9 | 5.6 | 2.6e-08 | 0.26 | 0.02 | 0.38 | TRUE |
| 14 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | ZNF831 | 0.22 | 0.03 | enet | 6 | 0.15 | 9.0e-05 | 11.7 | -8.7 | 4.3e-18 | -0.65 | 0.02 | 0.62 | TRUE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TH1L | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-03 | -5.0 | 5.4 | 7.8e-08 | 0.17 | 0.15 | 0.48 | TRUE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TUBB1 | 0.13 | 0.06 | blup | 50 | 0.04 | 2.3e-02 | -5.6 | 5.4 | 7.5e-08 | 0.13 | 0.01 | 0.53 | TRUE |