TWAS hub - TUBB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.485	0.1310	1.8e-03	0.004	0.024	0.110	NA	0.001	1.2e-01	3.4e-03	1.4e-09	NA	2.3e-01
2	TCGA	Breast Invasive Carcinoma	0.447	0.0697	8.6e-11	0.026	0.045	0.099	NA	0.071	3.0e-06	1.1e-09	1.3e-19	NA	2.4e-14
3	TCGA	Lung Squamous Cell Carcinoma	0.165	0.0968	8.1e-04	0.050	0.025	0.089	NA	0.048	2.4e-06	6.8e-04	2.7e-10	NA	3.8e-06
4	TCGA	Prostate Adenocarcinoma	0.512	0.1066	1.5e-06	0.056	0.049	0.125	NA	0.056	1.7e-06	6.4e-06	5.2e-13	NA	1.6e-06
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.132	0.0680	5.3e-03	0.057	0.044	0.011	NA	0.015	1.1e-02	2.3e-02	1.5e-01	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Platelet Count	7.6	88.4	278.9	-2.0	-4.9	3.1	-11.2	-16.7
Medication: Blood pressure	4.8	8.4	20.5	2.4	1.7	0.4	4.5	3.6
Hypertension (Self-reported)	4.0	11.2	28.9	1.8	1.0	0.3	4.8	5.4
High blood pressure	3.8	10.7	26.5	2.0	1.2	0.4	4.6	5.2
Medication for cholesterol, blood pressure or diabetes	3.6	6.0	15.3	-2.1	-1.0	0.6	-3.9	-3.0
Hearing difficulty/problems: Yes	3.5	5.3	8.6	-2.7	-2.9	-2.6	-1.9	-0.2
High cholesterol (Self-reported)	3.1	5.5	11.2	1.7	1.8	1.4	2.8	3.3
Diastolic blood pressure, automated reading	3.1	9.6	26.6	2.2	1.3	0.7	3.8	5.2
Vascular/heart problems diagnosed by doctor	3.1	8.4	19.6	-1.8	-0.9	0.2	-4.3	-4.4
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.3	5.2	2.1	2.0	0.7	2.3	1.6
Financial situation satisfaction	2.9	3.6	6.6	1.9	2.3	2.6	0.5	1.4
Medication: Atorvastatin	2.9	3.6	6.2	2.5	1.9	2.0	1.2	1.7
Townsend deprivation index at recruitment	2.7	3.7	8.9	-0.4	-2.1	-1.3	-3.0	-1.8
Systolic Blood Pressure	2.5	12.7	36.2	1.9	1.0	0.2	4.7	6.0
Medication: Cholesterol lowering	2.5	3.8	8.9	2.2	1.0	-0.2	3.0	2.1
Medication: Levothyroxine sodium	2.4	4.0	7.6	1.8	2.1	1.0	2.8	2.0
Falls in the last year	2.4	3.2	4.6	-0.5	-1.9	-2.0	-2.1	-1.9
Cardiovascular Disease	2.2	7.4	22.5	1.1	0.6	-0.3	3.5	4.7
Systolic blood pressure, automated reading	2.2	6.2	15.9	1.5	1.0	-0.0	3.5	4.0
Medication: Simvastatin	1.9	2.7	7.8	0.8	0.5	-0.2	2.8	2.2
Medication: Atenolol	1.8	2.2	6.4	0.5	0.5	1.2	1.6	2.5
Blood clot in the leg (DVT)	1.8	2.3	5.1	-0.3	-1.2	-1.4	-1.7	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	2.7	1.4	1.2	1.5	1.2	1.6
Ovarian Cancer	1.7	2.3	3.9	-1.7	-1.4	0.0	-2.0	-1.7
Alcohol usually taken with meals	1.7	2.7	5.6	-2.4	-1.8	-1.6	-1.4	-0.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	8.9	-1.0	-0.2	-3.0	0.7	-0.3
Average weekly beer plus cider intake	1.7	2.5	6.6	-1.0	-1.7	-0.4	-1.3	-2.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	5.0	1.8	2.2	1.3	2.2	1.2
Pain type(s) experienced in last month: Hip pain	1.6	2.0	7.6	-0.5	-0.9	-2.8	-0.8	-0.7
Alcohol drinker status: Never	1.6	1.9	6.2	-1.1	-0.6	-2.5	-0.9	-1.0
Ever had hysterectomy (womb removed)	1.5	1.7	3.5	-1.1	-1.3	-1.4	-1.9	0.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	5.3	0.8	2.3	0.9	1.1	0.5
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	4.2	0.0	-0.8	1.4	-2.1	-1.7
Number of live births	1.5	2.1	4.2	1.6	2.0	1.5	1.3	0.1
Number of treatments/medications taken	1.4	2.5	5.8	0.9	1.4	0.7	2.4	1.9
High blood pressure (mother)	1.4	2.0	4.1	1.2	1.0	0.8	2.0	1.7
Illnesses of siblings	1.4	1.9	3.9	-2.0	-0.9	1.0	-2.0	0.3
Depression (self-reported)	1.4	1.7	4.8	-0.5	-1.0	-0.3	-2.2	-1.4
High blood pressure (siblings)	1.4	2.1	4.8	2.2	0.6	0.2	1.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	4.7	-1.8	-1.5	-1.8	-1.2	-2.2
Primary Biliary Cirrhosis	1.3	1.9	7.6	0.5	-0.9	0.2	-1.0	-2.8
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.8	1.7	1.2	1.0	1.2	-0.9
Shortness of breath walking on level ground	1.3	1.5	4.7	1.2	0.5	2.2	0.6	0.9
Supplements: Vitamin C	1.3	1.5	5.0	0.8	0.9	2.2	0.9	-0.2
Breast Cancer	1.2	3.0	6.1	-0.9	-2.0	-1.6	-2.5	-1.2
HbA1C	1.2	1.3	3.2	0.4	-1.8	-0.4	-0.8	-1.5
Sensitivity / hurt feelings	1.2	2.0	4.0	-2.0	-1.5	-1.7	-1.0	0.2
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.5	-1.1	-1.6	-0.3	-1.6	-1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.5	1.0	0.8	-0.1	1.9	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.2	-1.8	-1.6	-1.6	-0.6	0.5
Osteoporosis (self-reported)	1.2	1.4	3.2	0.9	1.2	1.1	0.6	1.8
Eye problems/disorders: Glaucoma	1.2	1.4	2.4	1.3	1.5	1.4	0.8	0.5
Medication: Bendroflumethiazide	1.2	1.8	4.1	0.3	0.7	0.4	2.0	2.0
Medication: Lisinopril	1.2	1.5	4.9	-0.1	0.3	-0.9	2.2	1.4
Lupus	1.1	1.6	4.5	1.0	1.0	0.3	2.1	1.2
Waist Hip Ratio (WHR)	1.1	4.9	8.4	1.2	1.8	2.0	2.9	2.8
Had menopause	1.1	1.4	4.2	-1.3	-0.5	-2.1	-0.8	-0.5
Loud music exposure frequency	1.1	1.2	3.7	1.1	0.5	1.9	0.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.5	-1.6	-0.9	-1.3	-0.9	-1.1
Health satisfaction	1.1	1.4	3.8	0.0	1.9	1.3	1.1	0.7
Neck or shoulder pain in last month	1.1	1.6	2.3	-1.0	-1.2	-1.5	-0.9	-1.5
Medication: Aspirin	1.1	1.4	3.2	1.8	1.2	-0.0	1.4	0.7
Number of self-reported non-cancer illnesses	1.1	1.9	7.3	0.4	-0.3	0.5	1.3	2.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.2	-1.2	-1.1	-1.8	-0.6	0.2
Average weekly fortified wine intake	1.0	1.2	3.6	-0.4	-1.0	-0.7	-1.9	-0.8
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	-0.3	0.4	1.7	1.2	1.4
Angina (self-reported)	1.0	1.4	2.5	0.4	0.7	-1.3	1.6	1.4
Friendships satisfaction	1.0	1.3	4.0	0.6	1.3	2.0	-0.2	-0.2
Medication: Aspirin	1.0	1.3	3.4	1.8	1.3	0.0	1.1	0.3
Hearing aid user	1.0	1.1	2.2	-1.5	-1.5	-1.0	-0.3	-0.0
Medication: Blood pressure	1.0	1.9	6.2	0.2	0.2	0.4	1.8	2.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.2	-0.3	-0.8	-1.2	-1.1	-1.8
Angina	0.9	1.2	2.5	0.4	0.4	-1.6	1.3	1.2
Current tobacco smoking	0.9	1.5	4.6	-0.2	-0.9	0.1	-1.4	-2.2
Hair/balding pattern: Pattern 2	0.9	1.2	1.9	-0.7	-1.3	-1.3	-1.4	-0.2
Diabetes (self-reported)	0.9	1.4	3.2	1.8	1.3	0.8	1.2	0.6
Length of working week for main job	0.9	1.0	2.6	-0.2	0.8	-0.1	-1.3	-1.6
Wheeze or whistling in the chest in last year	0.9	1.5	3.0	-0.9	-1.7	-0.8	-1.6	-0.9
Eye problems/disorders: None of the above	0.9	1.0	2.7	-0.9	-1.2	-1.6	0.3	-0.3
Medication: Ibuprofen	0.9	1.1	4.7	0.1	0.5	0.6	-0.0	2.2
Illnesses of siblings: Diabetes	0.9	1.1	3.3	0.5	-0.2	-1.4	0.0	-1.8
Commuting to job workplace: Walk	0.9	0.9	2.8	0.9	1.7	0.8	-0.2	-0.6
Age started oral contraceptive pill	0.9	1.2	1.9	-1.3	-1.1	-1.4	-1.1	-0.3
Alzheimer’s Disease (including proxy)	0.8	1.1	2.3	-1.5	-1.5	-0.9	-0.5	-0.1
Crohns Disease (2017)	0.8	1.9	2.6	1.5	1.1	-1.0	1.5	1.6
Irritable Bowel Disease (IBD)	0.8	1.8	4.8	2.2	0.7	-0.8	1.4	1.1
Heel T-Score	0.8	6.3	19.2	-1.8	-1.3	-0.8	-2.7	-4.4
Respiratory disease	0.8	1.7	2.6	0.7	1.4	1.6	1.3	1.3
Diabetes (father)	0.8	0.9	2.9	0.7	-0.5	1.7	-0.8	0.6
Maternal smoking around birth	0.8	1.1	4.8	0.4	-0.3	2.2	-0.7	-0.3
Qualifications: CSEs or equivalent	0.8	1.0	3.1	1.8	0.1	1.2	0.7	0.0
Serious illness, injury or assault to yourself	0.8	0.9	1.8	1.3	0.9	1.3	-0.5	0.2
Qualifications: None of the above	0.8	1.7	4.5	-1.5	-2.1	-1.0	-0.3	-0.8
Fluid intelligence score	0.8	1.8	3.9	-0.8	0.2	-2.0	1.2	1.6
Hair/balding pattern: Pattern 3	0.8	1.2	3.4	0.6	0.4	-0.3	1.8	1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-0.3	2.0	0.7	0.2	2.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.3	0.3	1.8	1.3	0.4	1.0
Medication: Seretide 50 evohaler	0.8	1.0	2.1	0.2	0.8	1.5	1.2	0.8
Osteoarthritis (self-reported)	0.8	1.0	3.6	1.0	0.5	-0.1	0.1	-1.9
Risk taking	0.8	1.2	4.5	0.7	-0.1	-0.4	-0.8	-2.1
Pack years of smoking	0.8	1.2	3.6	-0.4	-0.6	-0.0	-1.3	-1.9
Age at First Birth	0.7	1.0	3.9	0.1	0.7	2.0	-0.1	0.8
Average weekly spirits intake	0.7	0.9	1.7	0.0	-1.3	-1.3	0.1	-1.0
Pack years adult smoking proportion	0.7	1.1	3.3	-0.3	-0.3	0.7	-1.2	-1.8
Impedance of leg (right)	0.7	3.2	6.9	-2.1	-0.4	-2.6	0.6	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.3	-1.3	-0.1	0.7	-0.7	-1.5
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	-0.5	-1.1	0.4	-1.5	0.0
Heart attack	0.7	0.9	2.3	-0.0	-0.9	-1.5	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.7	-1.3	-1.2	-1.8	-1.3	-1.9
Asthma	0.7	1.4	2.7	1.1	1.2	1.7	1.1	0.7
Lung cancer (father)	0.7	0.8	1.5	0.6	1.1	1.2	0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.8	-1.4	-1.4	-1.4	-1.2	-2.0
Birth weight of first child	0.7	1.3	2.5	1.6	1.1	-0.7	1.6	0.1
Diabetes diagnosed by doctor	0.7	1.1	2.7	1.6	1.0	0.8	1.0	0.4
Eye problems/disorders: Cataract	0.7	0.8	2.0	0.3	0.1	-0.1	-1.4	-1.4
Asthma (self-reported)	0.7	1.4	2.1	1.1	1.2	1.4	1.4	0.8
Smoking status: Current	0.7	1.2	3.0	-0.3	-1.1	-0.3	-1.2	-1.7
Myopia	0.7	1.0	2.9	-0.8	-0.8	0.6	0.7	1.7
Worry (Nagel 2018)	0.6	1.4	3.6	0.5	0.1	0.2	1.9	1.7
Verbal and Numeric Reasoning (VNR)	0.6	1.5	6.0	-1.0	0.1	-2.5	0.4	0.5
Prostate Cancer	0.6	0.8	1.9	-1.4	-0.1	-1.3	0.4	-0.3
Blood Red Count	0.6	5.7	21.2	0.1	1.6	-1.2	1.9	4.6
Severe depression (siblings)	0.6	0.7	1.8	-1.1	-0.6	-0.2	-0.4	1.3
Taking other prescription medications	0.6	0.9	2.1	-0.2	1.0	0.9	1.4	0.6
Impedance of leg (left)	0.6	3.1	4.9	-2.2	-0.8	-2.2	0.6	2.2
Nervous feelings	0.6	1.2	2.4	1.2	0.5	0.5	1.6	1.3
Forced vital capacity (FVC)	0.6	2.3	3.7	-1.2	-1.4	-1.7	-1.3	-1.9
Medication: Ramipril	0.6	0.8	2.2	-0.4	0.0	-0.6	1.0	1.5
Pulse rate	0.6	1.0	2.8	-0.2	-1.0	-1.7	-0.8	-0.7
Happiness	0.6	0.7	1.4	-0.1	1.2	0.9	0.7	0.8
Prospective memory result	0.6	0.8	1.8	-0.0	-0.7	0.5	-1.1	-1.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	0.8	-0.4	1.2	-0.7	-0.8
Age at first live birth	0.6	1.1	3.7	-0.0	-0.1	1.9	-0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	-0.6	-0.5	-1.0	-0.7	1.1
Overall health rating	0.6	1.2	4.1	0.5	0.6	0.0	1.1	2.0
Illnesses of father: Heart disease	0.6	0.9	3.1	0.2	0.1	-1.8	0.4	-1.0
Smoking status: Previous	0.6	0.9	1.9	0.1	0.2	-1.4	1.4	0.6
Loneliness, isolation	0.6	0.9	1.2	-1.1	-0.9	-0.7	-1.0	-1.0
Ever had bowel cancer screening	0.6	0.7	2.8	0.7	-0.3	-1.7	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.5	-1.2	-0.7	-0.3	-0.3	1.6
Medication for cholesterol	0.6	0.9	2.3	-0.2	-0.5	-0.7	-1.5	-1.2
Back pain experienced in last month	0.6	0.9	1.5	-0.9	-1.2	-1.0	-0.6	-0.9
Breast cancer (self-reported)	0.6	0.7	1.5	0.8	-0.4	-1.2	-0.7	-0.8
Miserableness	0.6	1.0	2.3	-1.0	-1.5	-0.7	-1.2	0.1
Commuting to job workplace: Public transport	0.6	0.7	1.4	-0.1	-0.4	-1.0	-1.2	-0.9
Unable to work because of sickness or disability	0.6	0.8	2.7	0.9	0.4	1.6	-0.7	-0.3
Cholesterol lowering medication	0.6	0.9	1.6	0.4	0.8	0.9	1.3	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	-0.0	-0.8	-1.5	-0.7	-0.7
Heart disease (siblings)	0.6	0.8	1.5	0.1	0.7	-0.7	1.1	-1.2
Depressed Affect (Nagel 2018)	0.5	1.0	3.5	-0.8	-0.8	0.1	0.7	1.9
Neuroticism (Nagel 2018)	0.5	1.1	2.5	-0.5	-1.1	-0.6	1.1	1.6
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	1.2	0.7	0.9	0.5	-0.3
Fasting Glucose	0.5	0.5	1.5	-0.1	0.9	0.6	0.3	-1.2
Neuroticism (2016)	0.5	0.7	2.1	-0.6	-1.5	-1.0	-0.2	0.3
Rheumatoid Arthritis	0.5	0.7	1.3	-0.6	-1.1	-0.6	-0.9	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.4	1.2	0.4	0.4	0.7	0.9
Neuroticism	0.5	1.2	3.7	-0.8	-1.0	-0.3	0.7	1.9
Relative age of first facial hair	0.5	1.1	2.5	0.1	0.5	1.6	0.4	1.5
Past tobacco smoking	0.5	0.9	2.9	-0.3	0.3	1.7	-1.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	0.4	0.9	1.1	0.6	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	-0.2	0.5	0.4	-0.4	1.7
Medication: Lansoprazole	0.5	0.6	1.3	-0.6	-1.2	0.4	-1.0	0.4
Illnesses of mother	0.5	0.6	1.8	-0.6	-0.4	-0.8	-1.3	-0.5
Hair/balding pattern: Pattern 4	0.5	1.2	2.6	-0.5	-0.8	1.3	-0.8	1.6
Headache pain in last month	0.5	0.9	1.5	1.1	1.2	0.3	1.1	0.5
Glaucoma (self-reported)	0.5	0.6	1.3	1.1	1.0	0.7	0.5	-0.2
Number of full brothers	0.5	0.7	1.5	1.2	0.0	-0.7	0.7	-1.0
Worry too long after embarrassment	0.5	0.8	2.5	0.2	0.1	0.0	1.3	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	2.2	0.2	0.1	1.5	-0.6	0.3
Number of full sisters	0.5	0.6	2.0	0.1	-1.4	-0.2	-0.9	-0.5
Average weekly red wine intake	0.5	0.8	1.9	-0.1	1.1	-0.6	1.4	0.6
Long-standing illness, disability or infirmity	0.5	0.8	2.5	0.8	-0.1	-0.1	0.9	1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	-0.7	-0.4	0.0	-1.3	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	-0.9	-0.4	-1.4	0.3	-0.4
Illnesses of father: High blood pressure	0.5	0.6	2.3	0.7	0.2	0.0	0.6	1.5
Supplements: Calcium	0.5	0.5	1.5	1.2	0.3	0.4	-0.8	0.5
Impedance of whole body	0.5	2.6	5.3	-2.3	-0.5	-2.2	0.2	1.6
Bipolar Disorder (2018)	0.4	0.7	1.3	0.9	0.5	0.2	1.1	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.5	-1.3	0.2	-2.1	0.1	-0.5
Alzheimer’s Disease (in father)	0.4	0.5	1.0	-0.7	-1.0	-0.8	-0.2	0.3
Ulcerative Colitis (UC)	0.4	0.8	3.9	2.0	0.2	-0.0	0.5	0.1
Crohns Disease (2012)	0.4	0.7	1.6	1.3	0.7	-0.4	0.2	1.1
Mean Putamen Volume	0.4	0.4	1.1	-1.1	-0.5	-0.2	-0.7	0.6
HDL Cholesterol	0.4	0.7	2.5	1.6	0.1	-0.6	-0.1	-0.9
LDL Cholesterol	0.4	0.7	1.6	-0.5	-0.5	0.0	-1.3	-1.2
Triglycerides	0.4	0.6	1.7	-0.3	0.7	1.3	-0.0	0.8
Ulcerative Colitis	0.4	0.6	2.1	1.5	-0.9	-0.1	-0.3	-0.3
Supplements: Zinc	0.4	0.4	1.5	0.6	-0.1	1.2	-0.3	-0.2
Medication: Co-codamol	0.4	0.5	0.9	0.5	0.5	-0.5	0.9	1.0
Diabetes (mother)	0.4	0.5	0.8	0.9	-0.7	-0.9	-0.0	-0.5
Relative age voice broke	0.4	0.6	1.3	-1.0	-0.7	-0.1	-1.1	0.1
Age when periods started (menarche)	0.4	0.9	1.6	1.0	1.3	0.6	1.1	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	0.4	-0.6	0.4	-1.0	-0.6
Number of incorrect matches in round	0.4	0.6	1.5	0.6	-0.8	-0.3	-0.7	-1.2
Financial difficulties in last 2 years	0.4	0.6	1.4	0.7	-0.4	0.9	-1.2	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-0.7	-0.9	1.1	-0.5	0.5
Worrier / anxious feelings	0.4	0.7	2.9	0.5	0.1	-0.0	0.5	1.7
Noisy workplace	0.4	0.5	1.2	-0.6	-0.8	0.4	-0.4	-1.1
Leg fat percentage (right)	0.4	1.3	4.6	-0.5	-1.3	-2.1	0.4	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.6	1.3	0.5	0.2	-0.4	-0.7
Qualifications: College or University degree	0.4	1.2	2.0	0.5	1.4	1.3	0.3	1.4
Emphysema/chronic bronchitis	0.4	0.5	0.9	-0.6	0.4	0.9	0.4	0.9
Chest pain or discomfort	0.4	0.6	1.4	-1.1	-1.2	-0.6	-0.1	0.4
Knee pain experienced in last month	0.4	0.7	1.1	0.5	0.8	0.5	1.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	-0.8	-0.5	0.5	-1.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	-0.8	-0.6	-0.3	-1.0	-0.2
Medication: Gliclazide	0.4	0.5	1.4	1.2	0.8	0.2	0.4	0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.6	-0.6	-0.4	-0.8	-1.3	-0.2
Mother’s age at death	0.4	0.5	1.7	0.1	0.8	-0.2	0.3	1.3
Leg fat percentage (left)	0.4	1.3	3.8	-0.5	-1.5	-2.0	0.4	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.0	0.6	-0.4	0.4	-0.8	-1.0
Pain experienced in last month	0.4	0.6	1.7	0.1	0.4	1.3	-0.0	1.2
Bipolar Disorder or Schizophrenia	0.3	0.8	1.6	1.2	0.9	0.1	1.2	0.5
Depression (Nagel 2018)	0.3	0.5	1.7	-0.0	0.2	0.9	-0.4	-1.3
Schizophrenia (2018)	0.3	0.7	1.6	1.2	1.2	-0.0	0.7	-0.1
Major Depression (MDD)	0.3	0.4	1.5	-1.2	-0.3	0.3	0.2	0.4
Reaction Time	0.3	0.5	1.0	0.6	0.7	0.7	-1.0	0.4
Coronary Artery Disease (CAD)	0.3	0.3	1.3	-0.5	0.0	0.0	0.0	-1.1
Hypothyroidism (self reported)	0.3	0.6	0.9	0.5	1.0	0.9	0.9	0.6
Tanning	0.3	3.4	4.7	-1.9	-2.2	-1.2	-2.1	-1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.8	-0.4	-0.6	0.3	1.0
Medication: Metformin	0.3	0.5	0.8	0.3	0.6	0.9	0.7	0.8
Trunk fat percentage	0.3	1.2	3.1	-0.6	-1.8	-1.6	-0.0	-0.0
Multivitamins +/- minerals	0.3	0.4	1.0	0.1	0.8	1.0	-0.6	-0.0
Stomach or abdominal pain in last month	0.3	0.4	1.5	-0.7	-0.1	-0.2	-0.2	-1.2
Supplements: Glucosamine	0.3	0.3	0.8	-0.3	-0.9	-0.9	-0.1	-0.2
Hearing difficulty/problems with background noise	0.3	0.5	0.8	-0.9	-0.9	-0.7	-0.8	-0.2
Pain all over the body in last month	0.3	0.3	0.6	0.8	-0.3	-0.8	-0.2	0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.9	-0.5	-0.7	-1.4	0.3	-0.1
Breastfed as a baby	0.3	0.3	0.5	-0.7	-0.2	-0.5	0.7	0.7
Pulse wave reflection index	0.3	0.3	0.6	0.7	0.6	0.4	0.8	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.7	0.8	0.3	0.6	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.3	1.7	-1.1	-1.3	-1.1	-0.6	-1.3
Body fat percentage	0.3	1.3	3.3	-0.5	-1.6	-1.8	0.1	-0.1
Number of children fathered	0.3	0.4	1.6	0.0	0.5	-1.3	-0.0	-0.0
Migraine (self-reported)	0.3	0.4	1.0	-0.6	-0.7	-0.1	0.4	1.0
Mean time to correctly identify matches	0.3	0.6	1.4	0.8	1.2	0.8	-0.4	0.4
Heart disease (mother)	0.3	0.4	1.4	0.5	0.1	1.2	0.4	0.2
Suffer from ‘nerves’	0.3	0.4	0.9	-0.2	-0.8	-0.6	0.6	1.0
Age at last live birth	0.3	0.5	0.8	-0.4	-0.8	0.7	-0.9	0.7
Family relationship satisfaction	0.3	0.4	1.2	0.7	1.1	0.6	-0.2	-0.2
Leg pain on walking	0.3	0.4	1.1	-1.0	0.8	0.0	0.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	0.1	0.4	-0.7	1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.2	0.2	-1.1	0.8	-1.1	-0.7
Leg fat-free mass (right)	0.3	1.4	3.0	1.4	-0.7	1.7	-0.2	-1.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.3	0.4	0.4	-0.5	1.0
Qualifications: nursing, teaching	0.3	0.4	1.8	0.2	1.3	0.5	0.4	-0.0
Leg predicted mass (right)	0.3	1.4	2.9	1.4	-0.7	1.7	-0.2	-1.2
Wears glasses or contact lenses	0.3	0.4	1.5	0.4	-0.2	0.0	0.6	1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.1	0.2	-0.6	0.8	0.9
Ever smoked	0.3	0.6	1.4	0.9	0.5	-0.4	1.2	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	0.9	0.5	0.4	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.7	-0.8	0.2	-0.6	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	-0.1	0.8	-0.5	1.0	-0.0
Alcohol drinker status: Previous	0.3	0.3	1.0	0.0	-0.6	0.1	0.6	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.8	-0.1	0.4	-0.2	0.2
Smoking Status	0.2	0.4	0.9	0.2	-0.2	-1.0	-0.2	-0.8
Allergy or Eczema	0.2	0.6	1.8	-0.7	-0.1	-0.7	-0.1	-1.3
Lung FEV1/FVC ratio	0.2	0.8	2.4	-0.7	0.2	-1.0	-0.5	-1.5
Lung FVC	0.2	0.9	2.1	-0.7	0.0	-1.3	0.1	-1.5
Hair Pigment	0.2	7.0	10.9	2.9	1.7	3.3	1.6	3.2
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.5	-0.0	0.4	0.7	0.4
Vitamin and mineral supplements	0.2	0.3	0.5	-0.4	-0.7	-0.7	-0.0	0.4
Leg fat-free mass (left)	0.2	1.1	2.0	1.4	-0.6	1.3	-0.2	-1.1
Hand grip strength (right)	0.2	0.5	1.7	0.1	0.2	0.9	1.3	0.4
Fed-up feelings	0.2	0.4	1.1	0.1	0.1	1.1	0.6	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	-1.0	-0.6	0.0	-0.9	-0.6
Leg predicted mass (left)	0.2	1.0	1.7	1.3	-0.6	1.2	-0.3	-1.1
Trunk fat mass	0.2	1.0	3.5	-0.5	-1.9	-1.2	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.1	0.1	0.8	-0.4	-0.8
Mouth/teeth dental problems	0.2	0.4	0.7	0.4	0.6	0.8	-0.6	-0.5
Neuroticism score	0.2	0.3	0.7	-0.5	-0.8	-0.2	0.1	0.7
Time employed in main current job	0.2	0.3	0.6	-0.8	-0.6	-0.4	-0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.4	-1.2	0.1	0.7	0.1	0.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.6	0.6	0.0	0.5	0.2
Impedance of arm (left)	0.2	0.9	2.4	-1.6	-0.2	-1.3	-0.1	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.8	0.6	-0.0	0.1	0.0
Tense / ‘highly strung’	0.2	0.3	1.3	-0.0	-0.0	-0.0	1.1	0.0
Medication: Paracetamol	0.2	0.4	0.6	-0.4	-0.8	0.4	-0.7	-0.7
Birth weight	0.2	0.5	1.0	0.3	-0.1	-0.7	1.0	-0.9
Comparative body size at age 10	0.2	0.6	1.7	0.3	-0.4	-1.3	-0.7	-0.7
Pulse wave peak to peak time	0.2	0.2	0.5	-0.7	-0.7	-0.0	-0.5	-0.2
Whole body fat mass	0.2	0.7	2.3	-0.2	-1.5	-1.0	0.1	-0.2
Leg fat mass (right)	0.2	0.8	2.5	-0.4	-1.6	-1.2	0.0	-0.4
Had major operations	0.2	0.2	0.7	0.9	0.1	0.5	-0.2	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.1	-0.5	0.6	0.8	0.0
Whole body fat-free mass	0.2	0.9	1.5	1.1	-0.8	1.2	-0.2	-0.9
Arm fat percentage (left)	0.2	0.7	1.7	0.2	-1.3	-0.9	-0.0	-0.8
Mood swings	0.2	0.3	0.9	-0.3	-1.0	-0.3	-0.7	-0.2
Whole body water mass	0.2	0.9	1.6	1.2	-0.7	1.2	-0.2	-0.9
Guilty feelings	0.2	0.2	0.7	-0.8	-0.5	-0.5	-0.0	-0.1
Medication: Paracetamol	0.2	0.3	0.5	0.2	-0.6	0.7	-0.6	-0.4
Irritability	0.2	0.3	0.7	0.3	-0.8	-0.8	-0.5	-0.1
Leg fat mass (left)	0.2	0.8	2.7	-0.4	-1.7	-1.1	0.1	-0.4
Schizophrenia (2014)	0.1	0.2	0.6	0.8	0.0	-0.6	0.0	0.2
Blood Eosinophil Count	0.1	0.7	1.6	-0.8	-0.4	-0.1	0.9	1.3
Blood White Count	0.1	1.1	4.5	-0.3	-0.6	-2.1	0.3	-0.7
BMI	0.1	0.5	1.2	1.1	-0.5	0.2	0.5	-0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.5	-0.2	0.2	0.0	-0.7
Chronotype (morning person)	0.1	0.2	0.5	-0.2	-0.7	-0.4	0.3	0.4
Hand grip strength (left)	0.1	0.2	0.4	-0.7	-0.6	0.1	-0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.1	0.1	0.6	0.9	-0.5
Sitting height	0.1	1.0	2.7	-0.5	-1.6	-1.0	-0.8	0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.4	-0.4
Body mass index (BMI)	0.1	0.6	1.0	0.9	-0.9	-0.0	-0.1	-1.0
Waist circumference	0.1	0.4	1.0	0.8	-0.4	0.6	1.0	0.2
Had other major operations	0.1	0.1	0.2	-0.1	0.1	-0.2	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.3	-0.2	0.7	0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.3	0.2	0.4	0.2	-0.4
Allergy	0.1	0.2	0.6	0.1	0.1	-0.8	0.7	0.2
Weight	0.1	0.5	1.5	0.7	-1.2	0.2	-0.1	-0.5
Impedance of arm (right)	0.1	0.5	1.0	-1.0	0.1	-0.9	-0.5	0.6
Arm fat percentage (right)	0.1	0.5	1.1	0.6	-1.1	-0.7	-0.0	-0.7
Trunk fat-free mass	0.1	0.6	1.2	1.0	-0.8	1.1	-0.2	-0.6
Hip circumference	0.1	0.6	1.2	0.7	-1.0	0.0	-0.6	-1.1
Father’s age at death	0.1	0.1	0.2	0.1	0.4	-0.2	-0.4	-0.3
Arm fat mass (right)	0.1	0.4	1.0	0.6	-1.0	-0.1	-0.3	-0.7
Trunk predicted mass	0.1	0.7	1.2	1.1	-0.8	1.1	-0.2	-0.7
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.3	0.1	-0.8	-0.2	-0.3
Gout (self-reported)	0.1	0.1	0.3	0.2	-0.2	-0.4	0.4	-0.5
Medication: Amlodipine	0.1	0.1	0.3	0.3	-0.5	-0.4	0.1	0.2
Arm fat-free mass (right)	0.1	0.4	1.1	0.4	-1.0	0.5	0.1	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.0	-0.5
Medication: Allopurinol	0.1	0.1	0.4	-0.0	0.1	0.5	0.6	0.2
Medication: Omeprazole	0.1	0.2	0.7	-0.3	-0.1	0.8	0.0	-0.1
Arm predicted mass (right)	0.1	0.5	1.7	0.3	-1.3	0.4	-0.1	-0.6
Pulse rate, automated reading	0.1	0.3	0.8	0.5	0.9	-0.1	-0.1	-0.4
Alcohol intake frequency.	0.1	0.2	0.5	-0.3	-0.4	0.2	-0.7	0.6
Comparative height size at age 10	0.1	0.4	0.9	-0.9	-0.3	0.9	-0.1	-0.2
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.0	0.2	0.3	0.4
Arm fat mass (left)	0.1	0.4	1.2	0.4	-1.1	-0.3	-0.1	-0.8
Basal metabolic rate	0.1	0.7	1.1	1.0	-0.9	1.1	-0.3	-0.8
Arm fat-free mass (left)	0.1	0.4	0.6	0.8	-0.7	0.7	0.0	-0.4
Number of operations (self-reported)	0.1	0.1	0.2	0.5	-0.3	0.0	0.2	0.2
Ever depressed for a whole week	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.4	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.4	0.5	-0.1	-0.1	0.1
Arm predicted mass (left)	0.1	0.5	1.0	1.0	-0.8	0.9	-0.1	-0.4
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	0.2	0.2	0.1	-0.1	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.6	1.4	-0.2	-0.6	1.2	0.7	0.9
Standing height	0.0	0.4	1.0	-0.6	-1.0	0.2	-0.1	0.8
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	-0.4

Hub : Genes

TUBB1

Models

Trait associations