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chr20:61,522,825-62,912,463

Best TWAS P=2.24e-12 · Best GWAS P=4.58e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LIME1	0.04	0.00	bslmm	439	0.01	3.3e-02	-3.3	5.3	1.2e-07	-0.17	0.28	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TPD52L2	0.13	0.07	bslmm	418	0.08	4.5e-10	-4.9	5.5	3.7e-08	-0.36	0.72	0.27	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZBTB46	0.11	0.08	lasso	3	0.07	1.2e-08	-6.9	-7.0	2.2e-12	1.00	0.00	1.00	TRUE
4	GTEx	Adipose Subcutaneous	TCEA2	0.11	0.06	lasso	2	0.03	9.4e-04	5.2	5.1	2.8e-07	-0.10	0.29	0.25	TRUE
5	GTEx	Adrenal Gland	OPRL1	0.48	0.29	enet	21	0.22	1.5e-08	-5.6	-5.3	1.0e-07	0.31	0.80	0.18	TRUE
6	GTEx	Adrenal Gland	RGS19	0.32	0.20	lasso	8	0.21	5.8e-08	-5.6	-5.8	5.2e-09	0.26	0.41	0.14	FALSE
7	GTEx	Artery Aorta	TPD52L2	0.16	0.07	enet	15	0.16	4.4e-09	1.9	-5.3	1.2e-07	0.20	0.70	0.04	FALSE
8	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	-5.6	-6.5	7.9e-11	0.35	0.75	0.25	FALSE
9	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	-5.6	6.0	1.9e-09	-0.23	0.39	0.11	FALSE
10	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	-5.6	-5.7	9.3e-09	0.26	0.72	0.20	FALSE
11	GTEx	Artery Tibial	RGS19	0.12	0.07	lasso	2	0.07	2.8e-06	5.5	-5.4	7.8e-08	0.25	0.82	0.13	TRUE
12	GTEx	Breast Mammary Tissue	GMEB2	0.18	0.02	lasso	5	0.06	3.0e-04	-3.3	-5.2	1.8e-07	0.11	0.16	0.04	TRUE
13	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	5.5	-5.6	2.0e-08	0.26	0.86	0.14	FALSE
14	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	-4.0	-5.6	2.5e-08	0.38	0.47	0.12	FALSE
15	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	-5.6	-6.1	8.4e-10	0.30	0.77	0.23	TRUE
16	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	-5.6	-5.6	1.9e-08	0.25	0.75	0.22	FALSE
17	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	-5.6	-5.3	1.4e-07	0.26	0.76	0.18	FALSE
18	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	5.5	-5.3	1.4e-07	0.27	0.88	0.12	FALSE
19	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	-5.6	-6.0	2.3e-09	0.24	0.77	0.23	TRUE
20	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	-5.6	-5.5	3.6e-08	0.27	0.81	0.19	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RGS19	0.51	0.28	enet	28	0.32	4.3e-18	-5.6	-5.7	1.5e-08	0.23	0.77	0.23	FALSE
22	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	5.5	-5.7	9.0e-09	0.27	0.83	0.17	FALSE
23	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	-5.6	-5.9	4.4e-09	0.28	0.79	0.21	FALSE
24	GTEx	Stomach	OPRL1	0.36	0.23	enet	16	0.19	1.3e-09	-5.6	-6.3	2.3e-10	0.28	0.77	0.22	FALSE
25	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	-5.6	-5.7	1.3e-08	0.25	0.77	0.23	FALSE
26	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	5.5	-5.7	1.2e-08	0.35	0.79	0.21	FALSE
27	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	5.5	-6.3	3.5e-10	0.27	0.07	0.06	FALSE
28	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	5.7	5.4	6.0e-08	-0.26	0.79	0.20	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	ZBTB46	0.11	0.07	lasso	1	0.06	5.2e-08	-6.9	-6.9	4.6e-12	1.00	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS19	0.03	0.02	blup	48	0.02	6.9e-06	5.3	-5.2	1.9e-07	0.14	0.02	0.97	TRUE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	-5.6	-5.6	1.9e-08	0.25	0.00	0.96	FALSE
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS19	0.11	0.00	blup	48	0.03	1.7e-02	5.3	-5.5	2.9e-08	0.19	0.02	0.62	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS19	0.07	0.05	blup	48	0.07	1.1e-07	-4.1	-5.9	3.9e-09	0.28	0.03	0.97	TRUE
34	The Cancer Genome Atlas	Thyroid Carcinoma	UCKL1AS	0.05	0.02	blup	41	0.03	4.6e-04	4.1	-5.6	2.8e-08	0.16	0.06	0.28	TRUE