Best TWAS P=6.8e-22 · Best GWAS P=2.04e-23 conditioned to 0.00635
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TNNT3 | 0.21 | -0.01 | enet | 17 | 0.00 | 6.4e-01 | -2.6 | -7.3 | 2.1e-13 | -0.30 | 0.05 | 0.06 | TRUE |
| 2 | GTEx | Artery Aorta | MRPL23-AS1 | 0.22 | 0.07 | enet | 10 | 0.12 | 2.9e-07 | 6.8 | 6.3 | 3.0e-10 | 0.45 | 0.97 | 0.01 | FALSE |
| 3 | GTEx | Artery Tibial | MRPL23-AS1 | 0.27 | 0.10 | lasso | 6 | 0.19 | 1.5e-14 | 3.2 | 5.3 | 9.6e-08 | 0.43 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | MRPL23-AS1 | 0.26 | 0.07 | enet | 11 | 0.10 | 6.3e-04 | 3.2 | 5.8 | 7.7e-09 | 0.41 | 0.24 | 0.06 | FALSE |
| 5 | GTEx | Brain Cerebellum | MRPL23-AS1 | 0.25 | 0.14 | enet | 12 | 0.18 | 6.8e-06 | 4.9 | 5.6 | 2.2e-08 | 0.46 | 0.27 | 0.24 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | MRPL23-AS1 | 0.36 | 0.23 | lasso | 3 | 0.21 | 3.8e-06 | 6.8 | 6.8 | 9.9e-12 | 0.49 | 0.34 | 0.30 | FALSE |
| 7 | GTEx | Brain Nucleus accumbens basal ganglia | MRPL23-AS1 | 0.25 | 0.07 | lasso | 5 | 0.03 | 6.8e-02 | 4.7 | 5.2 | 2.3e-07 | 0.40 | 0.10 | 0.17 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | MRPL23-AS1 | 0.30 | 0.15 | lasso | 5 | 0.19 | 6.4e-10 | 4.7 | 5.4 | 8.5e-08 | 0.29 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | MRPL23-AS1 | 0.24 | 0.06 | lasso | 4 | 0.01 | 1.9e-01 | 4.7 | 5.3 | 1.1e-07 | 0.29 | 0.08 | 0.05 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | LSP1 | 0.21 | 0.04 | enet | 28 | 0.06 | 3.4e-05 | 10.0 | 7.3 | 3.3e-13 | 0.72 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Colon Sigmoid | MRPL23-AS1 | 0.39 | 0.13 | lasso | 6 | 0.23 | 9.8e-09 | 4.9 | 5.6 | 1.9e-08 | 0.37 | 0.92 | 0.01 | FALSE |
| 12 | GTEx | Esophagus Muscularis | MRPL23-AS1 | 0.21 | 0.07 | lasso | 4 | 0.10 | 1.8e-06 | 4.9 | 5.5 | 3.0e-08 | 0.44 | 0.93 | 0.01 | FALSE |
| 13 | GTEx | Nerve Tibial | MRPL23-AS1 | 0.18 | 0.11 | lasso | 4 | 0.16 | 1.2e-11 | 5.3 | 5.7 | 9.5e-09 | 0.43 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | TNNT3 | 0.33 | 0.16 | lasso | 7 | 0.17 | 2.0e-09 | 8.7 | 9.1 | 1.2e-19 | 0.91 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | MRPL23-AS1 | 0.33 | 0.19 | enet | 30 | 0.21 | 9.5e-12 | 5.3 | 5.8 | 4.9e-09 | 0.37 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | TNNT3 | 0.63 | 0.02 | lasso | 20 | 0.00 | 3.5e-01 | -5.1 | 5.9 | 3.3e-09 | 0.38 | 0.04 | 0.10 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | MRPL23-AS1 | 0.19 | 0.19 | enet | 9 | 0.21 | 5.3e-17 | 4.9 | 6.2 | 5.7e-10 | 0.45 | 1.00 | 0.00 | FALSE |
| 18 | NTR | Blood | TNNT3 | 0.04 | 0.02 | blup | 461 | 0.02 | 4.3e-06 | 7.3 | -5.2 | 1.6e-07 | -0.66 | 0.10 | 0.90 | FALSE |
| 19 | YFS | Blood | TNNT3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.9e-05 | 8.7 | -7.6 | 2.7e-14 | -0.81 | 0.04 | 0.96 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LSP1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 5.0e-11 | -9.1 | -9.6 | 6.8e-22 | -0.60 | 0.10 | 0.90 | TRUE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOC100133545 | 0.06 | 0.02 | blup | 49 | 0.03 | 6.7e-03 | -4.0 | 5.2 | 2.3e-07 | 0.37 | 0.06 | 0.41 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LSP1 | 0.06 | 0.04 | enet | 6 | 0.04 | 3.1e-05 | 7.8 | 7.1 | 1.4e-12 | 0.11 | 0.65 | 0.04 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC100133545 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.1e-02 | 5.3 | 6.3 | 3.4e-10 | 0.39 | 0.00 | 0.88 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LSP1 | 0.07 | 0.03 | lasso | 4 | 0.03 | 2.4e-04 | 7.8 | -9.4 | 5.5e-21 | -0.35 | 0.09 | 0.25 | FALSE |
| 25 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNNI2 | 0.11 | 0.09 | lasso | 2 | 0.08 | 4.1e-06 | 7.8 | -7.8 | 7.2e-15 | -0.19 | 0.62 | 0.05 | FALSE |