Best TWAS P=2.57e-21 · Best GWAS P=3.04e-17 conditioned to 0.0535
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Colon Transverse | IL18R1 | 0.14 | 0.00 | enet | 41 | 0.00 | 2.1e-01 | 2.4 | 5.8 | 6.0e-09 | -0.45 | 0.06 | 0.16 | FALSE |
2 | ROSMAP | Brain Pre-frontal Cortex | IL1RL2 | 0.08 | 0.02 | enet | 33 | 0.03 | 2.3e-04 | 4.0 | -5.8 | 7.1e-09 | 0.18 | 0.19 | 0.06 | FALSE |
3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL1RL1 | 0.04 | 0.03 | lasso | 7 | 0.03 | 8.1e-04 | -8.3 | -8.4 | 4.8e-17 | 0.90 | 0.02 | 0.93 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL18R1 | 0.05 | 0.01 | blup | 108 | 0.03 | 1.8e-07 | -8.2 | 6.6 | 5.6e-11 | -0.78 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL1RL1 | 0.02 | 0.01 | blup | 78 | 0.01 | 1.5e-03 | 8.2 | -8.2 | 2.3e-16 | 0.68 | 0.03 | 0.86 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL1RL1 | 0.04 | 0.04 | lasso | 8 | 0.04 | 1.7e-05 | -7.6 | -8.9 | 3.8e-19 | 0.81 | 0.11 | 0.75 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL18RAP | 0.03 | 0.02 | blup | 94 | 0.02 | 1.2e-03 | -8.2 | 7.6 | 2.7e-14 | -0.81 | 0.00 | 0.93 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL1RL1 | 0.08 | 0.08 | enet | 9 | 0.08 | 1.2e-09 | -7.5 | -8.9 | 8.0e-19 | 0.61 | 0.91 | 0.09 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL1RL2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.9e-04 | -5.6 | -5.7 | 1.3e-08 | 0.37 | 0.06 | 0.41 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IL1RL1 | 0.18 | 0.06 | blup | 78 | 0.15 | 3.7e-09 | 8.2 | -9.3 | 2.0e-20 | 0.59 | 0.06 | 0.94 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL1RL1 | 0.03 | 0.01 | blup | 78 | 0.02 | 4.7e-03 | -7.4 | -9.5 | 2.6e-21 | 0.76 | 0.09 | 0.40 | TRUE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IL1RL1 | 0.19 | 0.05 | blup | 78 | 0.10 | 7.1e-05 | 8.3 | -9.3 | 2.1e-20 | 0.84 | 0.03 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | IL1RL1 | 0.05 | 0.03 | enet | 6 | 0.03 | 9.7e-04 | -7.5 | -7.7 | 1.8e-14 | 0.51 | 0.64 | 0.14 | FALSE |