TWAS hub - IL1RL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1810	0.0470	2.2e-08	0.051	0.072	0.091	0.094	0.092	7.5e-07	3.8e-09	3.5e-11	1.8e-11	2.7e-11
2	ROSMAP	Brain Pre-frontal Cortex	0.0798	0.0310	2.4e-04	0.019	0.019	0.026	0.021	0.007	1.4e-03	1.6e-03	2.3e-04	8.5e-04	4.0e-02
3	TCGA	Breast Invasive Carcinoma	0.0217	0.0104	4.9e-03	0.018	0.002	0.010	NA	0.012	1.0e-04	1.3e-01	2.6e-03	NA	1.1e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0429	0.0240	9.8e-03	0.036	0.019	0.031	NA	0.027	6.3e-05	3.0e-03	1.9e-04	NA	4.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Allergy	43.0	98.9	190.4	6.0	12.9	-1.8	13.8
Blood Eosinophil Count	42.8	330.0	835.2	-10.4	-19.4	-0.3	-28.9
Allergy or Eczema	37.8	99.5	219.0	-6.1	-11.7	2.1	-14.8
Hayfever, allergic rhinitis or eczema	34.5	75.0	153.8	-5.4	-10.7	1.7	-12.4
Asthma (self-reported)	33.3	66.3	146.4	-4.7	-9.8	0.7	-12.1
Asthma	33.2	65.4	144.0	-4.8	-9.7	0.8	-12.0
Respiratory disease	31.8	70.7	166.4	-4.8	-9.5	1.5	-12.9
Medication: Ventolin 100micrograms inhaler	16.9	21.6	47.1	-1.6	-6.1	0.0	-6.9
Wheeze or whistling in the chest in last year	14.4	25.7	66.9	-1.8	-5.7	0.6	-8.2
Hayfever/allergic rhinitis (self-reported)	13.3	17.7	33.5	-1.9	-5.8	1.1	-5.7
Number of self-reported non-cancer illnesses	6.5	11.4	26.5	-2.0	-5.2	0.5	-3.8
Taking other prescription medications	6.1	9.4	16.8	-1.5	-4.1	1.6	-4.0
Gout (self-reported)	5.3	7.3	13.7	2.4	3.7	2.5	1.8
Number of full brothers	4.1	5.2	8.6	-2.9	-2.8	0.2	-2.1
Medication: Atenolol	3.9	4.9	16.2	1.1	1.5	0.1	4.0
Mouth/teeth dental problems: Mouth ulcers	3.9	6.2	12.1	-2.3	-2.1	-3.5	-1.8
Coronary Artery Disease (CAD)	3.5	4.2	6.5	-1.9	-2.6	-1.4	-2.1
Heart attack/myocardial infarction (self-reported)	3.4	4.4	8.0	-2.8	-2.7	-1.2	-0.9
Number of treatments/medications taken	3.3	6.0	14.6	-1.4	-3.8	-0.3	-2.7
Chest pain or discomfort	3.2	4.7	9.1	-1.4	-3.0	1.2	-2.5
Heart attack	3.1	4.0	7.1	-2.7	-2.5	-1.2	-1.1
Medication: Seretide 50 evohaler	2.9	3.3	9.0	0.6	-1.7	0.9	-3.0
Lung FEV1/FVC ratio	2.8	14.4	22.5	3.4	4.7	-1.3	4.7
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	6.0	2.4	2.5	0.1	1.1
Commuting to job workplace: Cycle	2.8	3.4	5.6	2.4	1.9	1.1	1.7
Medication: Aspirin	2.7	3.5	7.5	-1.7	-2.7	-1.9	-0.4
Pack years adult smoking proportion	2.6	3.9	8.7	-1.6	-1.8	-3.0	-1.0
Fluid intelligence score	2.6	5.4	9.6	1.9	2.3	1.7	3.1
Breastfed as a baby	2.6	3.2	6.7	1.6	2.6	1.7	0.8
Medication for pain relief, constipation, heartburn	2.6	4.5	11.3	1.3	3.4	2.1	0.7
Chronic bronchitis/emphysema (mother)	2.4	2.8	6.4	-0.9	-1.7	-1.1	-2.5
Medication: Allopurinol	2.4	3.2	4.7	1.7	2.1	2.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	5.9	-1.8	-2.4	-0.5	-1.0
Medication: Cholesterol lowering	2.3	3.5	5.4	-2.3	-2.3	-1.7	-0.8
Nervous feelings	2.1	4.0	6.9	1.5	2.4	1.0	2.6
Shortness of breath walking on level ground	2.1	2.5	5.1	-1.3	-2.3	-1.5	-1.0
Mother’s age at death	2.1	2.6	6.3	1.4	2.5	0.4	1.3
High cholesterol (Self-reported)	2.1	3.7	8.1	-2.2	-2.8	-1.1	-0.8
Risk taking	2.1	3.0	4.1	-1.7	-1.6	-1.6	-2.0
Pack years of smoking	2.1	3.1	6.4	-1.6	-1.7	-2.5	-0.9
Migraine (self-reported)	2.0	2.5	3.5	1.8	0.7	1.9	1.6
Rheumatoid Arthritis	1.9	2.6	6.0	2.4	1.6	1.0	0.8
Length of working week for main job	1.9	2.1	3.0	-1.2	-1.7	-1.2	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	3.9	5.6	2.4	2.1	1.6	1.7
Exposure to tobacco smoke at home	1.8	2.0	3.1	-1.8	-1.5	-1.4	-0.6
Suffer from ‘nerves’	1.8	2.8	6.4	1.0	1.9	0.3	2.5
Medication: Aspirin	1.8	2.4	5.7	-1.3	-2.4	-1.5	-0.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	6.0	2.4	0.7	1.2	0.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	4.6	1.9	2.1	1.9	0.3
Overall health rating	1.7	3.6	7.1	-2.0	-2.7	-1.3	-1.2
Leg pain on walking	1.7	2.1	5.6	-0.7	-0.5	-2.4	-1.4
Number of live births	1.6	2.2	3.7	1.0	1.7	1.9	1.1
Long-standing illness, disability or infirmity	1.6	2.4	3.6	0.1	-1.6	1.9	-1.9
Primary Biliary Cirrhosis	1.5	2.1	3.4	-1.8	-1.7	-1.2	-0.8
Relative age voice broke	1.5	2.3	3.3	1.8	1.7	0.4	1.6
Had other major operations	1.5	1.9	3.7	-0.2	-1.9	-0.4	-1.9
Noisy workplace	1.5	1.8	5.7	-0.1	-1.1	-0.6	-2.4
Emphysema/chronic bronchitis	1.5	1.7	2.5	-1.4	-1.4	0.7	-1.6
Average weekly red wine intake	1.5	2.2	5.4	0.5	2.3	0.5	1.7
Medication: Gliclazide	1.5	1.7	2.8	1.7	0.1	1.4	1.4
Number of operations (self-reported)	1.5	2.2	4.8	-0.8	-1.8	-0.4	-2.2
Irritability	1.5	2.6	5.2	1.4	2.3	-0.2	1.8
Intelligence (Savage-Jansen 2018)	1.4	4.4	11.7	1.3	1.9	0.9	3.4
Ovarian Cancer	1.4	1.8	5.0	1.3	2.2	0.8	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.0	0.7	-1.7	0.9	-1.6
Heart disease (siblings)	1.4	1.7	3.5	-1.9	-1.2	-1.0	-1.0
Medication: Blood pressure	1.3	2.2	5.5	-1.1	-1.5	-2.3	-0.2
Angina (self-reported)	1.3	1.7	5.1	-1.0	-2.2	0.2	-0.9
Wears glasses or contact lenses	1.3	1.5	4.0	0.7	0.7	-1.0	2.0
Prostate Cancer	1.2	1.7	5.0	-2.2	-0.8	-0.8	-0.7
Crohns Disease (2012)	1.2	1.9	4.3	1.1	2.1	-0.5	-1.3
Hypothyroidism (self reported)	1.2	2.7	5.5	-1.7	-2.3	-0.2	-1.5
Angina	1.2	1.5	4.3	-1.0	-2.1	0.3	-0.9
Diabetes (mother)	1.2	1.6	3.1	-0.7	-1.3	-1.8	-1.0
Serious illness, injury or assault to yourself	1.2	1.5	3.4	1.8	1.3	0.9	0.2
Number of incorrect matches in round	1.2	2.0	4.4	0.2	2.1	-1.1	-1.5
Neuroticism score	1.2	2.6	4.5	1.0	2.1	0.8	2.0
Leg fat percentage (right)	1.2	4.2	7.8	-1.5	-2.1	-1.5	-2.8
Miserableness	1.2	2.0	3.8	0.7	1.2	1.6	2.0
Schizophrenia (2018)	1.1	2.3	4.1	0.5	2.0	1.1	1.9
Alzheimer’s Disease (including proxy)	1.1	1.5	3.6	0.9	0.5	1.9	1.2
Body Mass Index (BMI) (2010)	1.1	1.5	2.0	-1.3	-0.9	-1.4	-1.2
Neuroticism	1.1	2.5	6.6	0.4	2.6	1.4	1.2
Relative age of first facial hair	1.1	2.4	5.1	1.9	2.3	0.1	0.9
Severe depression (siblings)	1.1	1.2	2.1	1.0	1.5	1.2	0.3
Had menopause	1.1	1.4	3.1	1.4	1.8	0.6	0.6
Medication: Amlodipine	1.1	1.6	3.0	-0.4	-1.3	-1.7	-1.2
Qualifications: College or University degree	1.1	3.4	8.6	1.3	1.4	1.1	2.9
Had major operations	1.1	1.3	2.0	-1.0	-1.4	-1.1	-1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	4.8	-2.2	0.2	-0.7	0.1
Financial situation satisfaction	1.1	1.4	2.8	-0.9	-1.7	1.3	-0.6
Depressed Affect (Nagel 2018)	1.0	2.0	3.0	0.6	1.7	1.4	1.6
Crohns Disease (2017)	1.0	2.3	7.4	0.3	2.7	0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.1	1.8	0.3	1.2	-0.8
Supplements: Zinc	1.0	1.0	1.7	1.0	1.3	-1.0	-0.7
High blood pressure (mother)	1.0	1.4	4.4	1.0	0.1	-2.1	-0.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.7	-0.6	-1.3	-1.1	-1.1
Falls in the last year	1.0	1.3	3.2	-0.1	-1.4	0.1	-1.8
Medication: Lansoprazole	1.0	1.1	2.2	1.5	1.4	0.5	-0.2
Ever had bowel cancer screening	1.0	1.1	1.8	1.1	1.4	1.1	0.5
Friendships satisfaction	1.0	1.3	2.1	1.1	0.3	1.2	1.5
Leg fat percentage (left)	1.0	3.5	7.3	-1.2	-1.9	-1.3	-2.7
Neuroticism (Nagel 2018)	0.9	2.1	5.5	-0.1	2.4	0.3	1.7
Worry (Nagel 2018)	0.9	1.9	4.7	0.1	2.2	-0.3	1.7
Alzheimer’s Disease (in father)	0.9	1.0	1.6	-0.2	-1.0	1.1	1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.0	0.0	1.5	-0.5	2.5
Townsend deprivation index at recruitment	0.9	1.3	3.7	1.1	-0.0	0.4	-1.9
Fed-up feelings	0.9	1.5	2.1	1.2	1.0	1.5	1.3
Chronic bronchitis/emphysema (father)	0.9	1.1	2.5	1.2	0.4	1.6	0.6
Medication: Ramipril	0.9	1.2	2.7	0.9	0.1	-1.6	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.2	0.6	-1.5	-1.3	0.3
Medication: Ibuprofen	0.9	1.1	1.9	0.8	-1.2	-1.4	0.7
Commuting to job workplace: Walk	0.9	1.0	2.3	0.3	1.0	-1.5	-0.7
Back pain experienced in last month	0.9	1.3	2.6	1.6	1.2	0.6	0.9
Mineral and other dietary supplements	0.9	1.2	2.0	-0.8	-1.4	-1.4	-0.4
Breast cancer (self-reported)	0.9	1.1	3.7	-0.0	-0.8	0.0	-1.9
Bipolar Disorder (2018)	0.8	1.2	3.7	-0.3	0.9	0.4	-1.9
Bipolar Disorder (2011)	0.8	0.7	1.6	0.5	1.0	0.0	-1.3
Chronotype (morning person)	0.8	1.8	4.3	-1.2	-2.1	-0.9	-0.7
Financial difficulties in last 2 years	0.8	1.1	2.2	1.1	-0.8	1.5	-0.5
Illnesses of siblings	0.8	1.1	2.2	1.5	1.0	1.1	-0.5
Father’s age at death	0.8	1.0	2.4	1.1	1.6	-0.5	0.5
Illnesses of mother	0.8	0.9	2.0	-1.1	-0.5	1.4	-0.5
Loud music exposure frequency	0.8	0.8	2.4	0.9	-0.4	0.1	-1.5
Glaucoma (self-reported)	0.8	1.0	2.3	0.6	-1.5	-0.9	-0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.1	-1.8	-1.1	0.6	-1.3
Eye problems/disorders: None of the above	0.8	0.9	2.1	-1.4	-0.3	-1.0	-0.5
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.7	0.1	0.0	-0.1	-1.9
Medication: Omeprazole	0.8	0.9	1.4	-0.4	-1.2	-0.9	-1.2
Age at last live birth	0.8	1.1	4.2	0.5	-0.1	2.1	0.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.3	1.5	0.9	0.8	0.4
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.2	0.2	0.3	0.7	1.8
Medication: Atorvastatin	0.8	0.9	2.6	-1.1	-1.6	0.1	-0.2
Illnesses of father: High blood pressure	0.8	1.0	2.6	0.6	0.1	1.0	1.6
Fractured/broken bones in last 5 years	0.8	1.0	2.6	-0.4	-1.6	0.2	-1.1
Ever depressed for a whole week	0.8	0.9	2.5	-0.5	-1.6	-1.0	-0.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	0.6	1.0	1.3	0.1
Average weekly spirits intake	0.7	0.9	2.4	1.0	-0.2	1.5	0.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.3	-0.0	0.9	0.5	1.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.2	0.8	0.1	1.5	-0.3
Multivitamins +/- minerals	0.7	0.9	2.7	0.2	-0.8	1.6	-0.2
Diabetes (self-reported)	0.7	1.1	1.9	-1.0	-1.4	-1.1	-0.6
Medication: Simvastatin	0.7	1.0	1.5	-1.0	-1.2	-1.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.1	1.2	0.6	-0.7	1.4
Birth weight of first child	0.7	1.3	2.8	-1.3	-0.6	0.7	1.7
Pulse wave reflection index	0.7	0.9	2.0	-1.1	-0.0	-0.5	-1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	1.5	1.1	1.2	1.0	0.6
Number of full sisters	0.7	0.9	2.3	-0.3	0.6	0.9	1.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.7	-1.4	1.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.8	1.7	0.6	0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.5	0.5	-0.2	2.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.9	0.1	0.2	1.2	-1.4
Osteoarthritis (self-reported)	0.7	0.9	2.5	0.5	-0.8	-0.2	1.6
Ever taken oral contraceptive pill	0.7	0.8	1.4	-0.8	-0.5	-1.0	-1.2
Bipolar Disorder or Schizophrenia	0.6	1.5	4.7	0.2	2.2	1.1	0.3
Irritable Bowel Disease (IBD)	0.6	1.5	3.7	0.4	1.9	-0.1	-1.4
Lupus	0.6	0.8	1.2	-1.1	-0.9	0.5	1.1
Lung FVC	0.6	2.9	9.2	-3.0	-1.2	-0.1	0.9
Medication: Co-codamol	0.6	0.7	1.1	0.2	0.9	1.0	1.1
Maternal smoking around birth	0.6	0.9	2.4	0.9	0.5	1.5	0.0
Stomach or abdominal pain in last month	0.6	0.8	2.9	0.2	-0.5	0.3	-1.7
Medication: Levothyroxine sodium	0.6	1.1	3.4	-1.8	-0.5	0.8	-0.2
Alcohol usually taken with meals	0.6	1.0	1.6	0.5	1.3	-1.1	1.0
Pain all over the body in last month	0.6	0.7	2.2	-0.7	0.1	-0.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.5	-0.1	-1.9	-0.1	-0.5
Headache pain in last month	0.6	1.0	3.8	-0.4	-1.9	0.1	-0.5
Birth weight	0.6	1.3	2.6	0.6	1.6	1.1	1.0
Exposure to tobacco smoke outside home	0.6	0.7	2.2	0.0	-1.5	-0.1	-0.8
Pulse rate, automated reading	0.6	1.9	3.8	0.7	-1.9	1.9	0.2
Eye problems/disorders: Cataract	0.6	0.8	1.9	0.9	1.4	0.3	0.4
Average weekly champagne plus white wine intake	0.6	0.8	1.6	-1.2	0.1	-0.4	-1.3
Myopia	0.6	0.8	1.6	-0.4	-1.1	-0.5	-1.3
Basal cell carcinoma (self-reported)	0.6	0.8	2.3	0.4	0.7	0.3	1.5
Reaction Time	0.5	1.0	3.1	-0.8	-1.8	-0.4	-0.2
Fasting Glucose	0.5	0.6	1.6	-1.2	-0.2	0.4	0.7
HbA1C	0.5	0.5	1.0	-0.4	1.0	0.2	-1.0
Triglycerides	0.5	0.9	1.8	1.1	0.6	-0.1	1.3
Height	0.5	8.9	22.7	-0.6	2.2	2.8	4.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	0.8	0.0	1.2	0.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.0	-1.0	-0.7	0.1	1.0
Qualifications: CSEs or equivalent	0.5	0.6	1.4	0.0	0.3	-1.0	-1.2
Supplements: Glucosamine	0.5	0.6	0.8	0.9	0.2	0.9	0.9
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	1.3	0.6	-0.4	0.4
Forced vital capacity (FVC)	0.5	1.8	4.1	-2.0	-0.7	1.4	0.7
Mouth/teeth dental problems	0.5	0.7	1.0	0.4	1.0	0.9	1.0
Arm fat percentage (right)	0.5	2.1	5.3	-0.6	-0.8	-1.4	-2.3
Worrier / anxious feelings	0.5	1.0	1.9	0.9	1.4	0.3	1.2
Pulse rate	0.5	0.8	2.0	1.4	-0.3	0.6	-0.8
Arm fat mass (right)	0.5	1.9	4.5	-0.9	-1.0	-1.1	-2.1
Body fat percentage	0.5	2.1	5.5	-0.6	-0.8	-1.5	-2.3
Worry too long after embarrassment	0.5	0.8	1.9	-0.3	1.4	-0.2	1.0
Leg fat mass (right)	0.5	1.9	3.8	-0.9	-1.3	-1.2	-2.0
Supplements: Vitamin C	0.5	0.6	1.3	1.1	0.8	-0.8	-0.1
Smoking status: Previous	0.5	0.8	2.3	-0.4	0.4	-0.7	-1.5
Qualifications: nursing, teaching	0.5	0.8	1.3	1.1	1.1	0.8	-0.1
Commuting to job workplace: Public transport	0.5	0.6	1.9	0.6	-0.1	-1.4	0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.4	1.0	-1.2	-0.2	-0.3
Medication: Blood pressure	0.5	0.9	1.8	0.5	1.3	0.5	1.1
Medication: Lisinopril	0.5	0.6	1.5	-0.7	-0.7	-0.3	-1.2
Average weekly beer plus cider intake	0.5	0.7	2.1	0.1	-0.9	-0.3	-1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	0.0	1.0	1.1	0.1
Unable to work because of sickness or disability	0.5	0.6	2.4	0.2	0.1	0.4	-1.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.2	1.2	0.8	1.5	-1.0
Alcohol drinker status: Previous	0.5	0.5	1.3	0.5	0.6	1.2	0.4
Depression (Nagel 2018)	0.4	0.6	1.4	0.0	1.2	0.2	1.0
Age at First Birth	0.4	0.6	1.7	-0.3	-1.3	0.3	-0.5
Ulcerative Colitis	0.4	0.6	1.5	0.4	0.7	-0.3	-1.2
Hand grip strength (right)	0.4	1.0	1.5	-1.2	0.2	1.0	1.2
Age when periods started (menarche)	0.4	1.0	2.5	0.0	-0.0	1.6	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	1.3	0.7	0.2	1.0
High blood pressure	0.4	1.0	1.4	-1.2	-0.8	-1.2	0.8
Sitting height	0.4	3.2	6.5	-0.4	0.6	2.4	2.5
Body mass index (BMI)	0.4	1.8	4.6	-0.6	-0.9	-1.1	-2.1
Waist circumference	0.4	1.4	2.0	-1.0	-1.3	-1.0	-1.4
Happiness	0.4	0.5	0.7	0.8	0.4	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	0.6	-0.6	0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.0	-0.4	1.0	0.9	1.7
Impedance of arm (left)	0.4	1.6	3.6	1.1	1.9	0.3	1.3
Tense / ‘highly strung’	0.4	0.6	1.2	-1.1	0.1	-1.1	-0.2
Medication: Paracetamol	0.4	0.7	2.3	-0.5	-1.5	-0.3	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.5	3.1	-1.8	-0.2	1.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.7	1.3	0.7	-0.3	-0.3
Heart disease (mother)	0.4	0.5	1.0	0.4	-0.3	-1.0	0.8
Family relationship satisfaction	0.4	0.4	0.8	0.9	-0.0	0.8	-0.6
Knee pain experienced in last month	0.4	0.6	2.1	1.5	0.5	0.2	-0.0
Arm fat percentage (left)	0.4	1.4	4.0	-0.5	-0.4	-1.1	-2.0
Mood swings	0.4	0.7	2.5	0.2	0.6	0.1	1.6
Medication for cholesterol	0.4	0.6	1.5	1.2	-0.0	0.9	0.4
Osteoporosis (self-reported)	0.4	0.5	0.7	0.4	0.9	0.5	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-1.0	-0.8	0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.4	-0.3	0.9	-0.9
Medication: Bendroflumethiazide	0.4	0.5	1.3	0.8	0.5	-0.0	1.1
Medication: Paracetamol	0.4	0.6	1.4	-0.2	-1.2	-1.0	-0.4
Alcohol drinker status: Never	0.4	0.5	1.0	1.0	-0.7	-0.6	-0.2
Age started oral contraceptive pill	0.4	0.5	1.6	-1.3	-0.1	0.3	0.6
Diastolic blood pressure, automated reading	0.4	1.1	1.6	-1.3	-0.7	-1.1	-1.0
Leg fat mass (left)	0.4	1.7	4.0	-0.6	-1.2	-0.9	-2.0
Major Depression (MDD)	0.3	0.3	0.7	0.8	0.8	-0.1	-0.0
Breast Cancer	0.3	0.6	1.2	0.7	0.2	-0.9	1.1
Mean Putamen Volume	0.3	0.3	0.9	0.1	-0.5	-0.3	-0.9
HDL Cholesterol	0.3	0.5	1.9	0.1	-1.4	-0.4	-0.1
LDL Cholesterol	0.3	0.5	1.3	-1.1	-0.8	-0.2	-0.1
Neuroticism (2016)	0.3	0.4	0.8	-0.3	0.8	0.9	0.1
Schizophrenia (2014)	0.3	0.8	2.6	0.4	1.6	0.3	0.5
Blood White Count	0.3	2.2	4.5	-0.2	-1.6	1.2	-2.1
Tanning	0.3	4.3	8.1	-2.8	-2.5	-1.5	-0.5
Sensitivity / hurt feelings	0.3	0.5	0.8	0.4	0.9	-0.9	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.2	-0.6	-0.9	-0.2
Vitamin and mineral supplements	0.3	0.4	0.7	-0.4	0.6	-0.8	-0.5
Medication: Metformin	0.3	0.4	1.2	1.1	-0.3	0.4	-0.2
Impedance of leg (right)	0.3	1.6	3.1	-1.5	-1.8	-0.4	-1.0
Trunk fat percentage	0.3	1.3	3.3	-0.3	0.1	-1.3	-1.8
Trunk fat mass	0.3	1.1	2.7	-0.7	-0.4	-1.1	-1.6
Time employed in main current job	0.3	0.3	0.6	-0.2	-0.8	0.1	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	-1.0	0.4	0.7	1.6
Lung cancer (father)	0.3	0.4	0.9	0.3	-0.6	-0.9	-0.6
Pulse wave Arterial Stiffness index	0.3	0.3	1.0	-0.3	-0.3	-0.4	-1.0
Standing height	0.3	2.8	6.2	-0.7	0.8	1.9	2.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-0.5	-0.2	-1.3	1.2
Peak expiratory flow (PEF)	0.3	0.6	2.1	-0.5	0.1	1.5	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	0.2	-0.6	-0.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.1	0.8	0.7	-0.6
High blood pressure (siblings)	0.3	0.4	1.3	0.4	0.3	-0.0	1.1
Comparative body size at age 10	0.3	0.9	1.7	0.7	0.5	-1.3	1.1
Number of children fathered	0.3	0.3	0.6	0.4	-0.5	-0.8	0.4
Pulse wave peak to peak time	0.3	0.4	1.1	0.3	0.3	0.5	1.0
Health satisfaction	0.3	0.3	0.7	-0.8	-0.5	-0.4	-0.5
Whole body fat mass	0.3	1.4	3.4	-0.7	-0.8	-1.1	-1.9
Illnesses of father: Heart disease	0.3	0.5	0.9	-0.2	-0.9	-1.0	-0.1
Illnesses of siblings: Diabetes	0.3	0.3	0.6	0.1	0.8	-0.8	0.4
Arm fat mass (left)	0.3	1.4	3.6	-0.8	-0.8	-0.9	-1.9
Guilty feelings	0.3	0.4	0.9	-1.0	0.9	-0.3	-0.0
Hearing aid user	0.3	0.4	1.0	-0.3	-0.4	0.3	1.0
Supplements: Calcium	0.3	0.3	0.6	0.8	0.5	0.5	-0.2
Arm predicted mass (left)	0.3	1.4	2.4	-1.6	-1.4	0.6	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.3	0.5	0.5	0.7
Ulcerative Colitis (UC)	0.2	0.4	1.0	0.0	0.7	-0.2	-1.0
Blood Platelet Count	0.2	2.9	6.2	0.7	0.3	2.2	-2.5
Blood Red Count	0.2	2.4	3.9	2.0	1.9	0.3	1.4
BMI	0.2	1.3	2.2	-0.2	-1.2	-1.3	-1.5
Waist Hip Ratio (WHR)	0.2	1.0	2.3	-1.0	-1.5	-0.8	-0.2
Systolic Blood Pressure	0.2	0.9	1.4	-1.1	-0.8	-1.2	0.4
Cardiovascular Disease	0.2	0.7	1.6	-1.3	-0.4	-0.9	0.3
Hand grip strength (left)	0.2	0.4	1.0	-0.1	1.0	0.6	0.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.2	-0.6	0.7	-0.4
Current tobacco smoking	0.2	0.3	0.7	-0.4	-0.8	0.6	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.1	0.5	0.0	-0.8
Impedance of leg (left)	0.2	1.1	1.8	-1.1	-1.4	-0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	0.7	0.9	-0.2	0.8
Impedance of arm (right)	0.2	0.8	1.5	1.1	1.2	-0.2	0.7
Trunk fat-free mass	0.2	1.0	2.3	-1.5	-1.0	0.9	0.1
Alcohol intake versus 10 years previously	0.2	0.4	1.3	-0.1	0.1	0.4	1.1
Prospective memory result	0.2	0.3	0.6	0.7	0.5	0.4	-0.4
Trunk predicted mass	0.2	1.1	2.4	-1.6	-1.1	1.0	0.2
Age at first live birth	0.2	0.4	1.2	0.0	-0.7	1.1	0.2
Mean time to correctly identify matches	0.2	0.4	1.4	-0.1	-1.2	-0.3	0.3
Comparative height size at age 10	0.2	1.3	2.6	-1.5	-1.6	-0.1	-0.4
Hypertension (Self-reported)	0.2	0.7	1.5	-0.7	-0.3	-0.7	1.2
Smoking status: Current	0.2	0.3	0.5	-0.1	-0.7	0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.3	-0.8	-0.3	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.1	0.3	0.9	-0.5
Ever smoked	0.2	0.4	0.9	-0.8	0.0	-0.1	-1.0
Arm fat-free mass (left)	0.2	0.9	1.4	-1.2	-1.2	0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.8	-0.5	-0.3	-0.3
Pain experienced in last month	0.2	0.4	0.6	-0.6	0.8	0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	-0.0	0.2	0.6
Heel T-Score	0.1	0.8	2.2	0.7	-0.0	-1.5	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.3	1.1	0.0	0.1	-1.0	0.1
Hair Pigment	0.1	1.5	3.3	0.5	-1.1	-1.1	-1.8
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.7	-0.6	0.2	-0.2
Systolic blood pressure, automated reading	0.1	0.2	0.4	-0.6	0.3	-0.4	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	0.3	0.3	-0.2
Diabetes (father)	0.1	0.1	0.2	0.2	0.4	-0.5	-0.2
Average weekly fortified wine intake	0.1	0.1	0.1	0.2	-0.4	0.3	-0.3
Past tobacco smoking	0.1	0.3	0.9	0.1	-0.3	0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.5	0.3	0.3	-0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.1	0.5	0.7	0.4
Qualifications: None of the above	0.1	0.1	0.2	-0.4	0.3	-0.2	-0.5
Weight	0.1	0.4	0.7	-0.8	-0.4	-0.2	-0.9
Hip circumference	0.1	0.3	0.7	-0.0	0.5	-0.3	-0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.5	0.0	0.3	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.3	-0.7	-0.1	-0.5
Depression (self-reported)	0.1	0.2	0.3	0.6	-0.2	-0.5	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4
Arm fat-free mass (right)	0.1	0.7	2.1	-1.4	-0.7	0.3	-0.2
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.1	-0.7	-0.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.3	0.0	0.3	-0.7
Arm predicted mass (right)	0.1	0.5	1.3	-1.1	-0.5	0.5	-0.3
Alcohol intake frequency.	0.1	0.3	0.9	-0.7	-0.9	0.1	-0.2
Whole body fat-free mass	0.1	0.4	0.9	-1.0	-0.5	0.7	0.2
Loneliness, isolation	0.1	0.1	0.3	0.5	-0.1	0.1	-0.0
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.1	-0.7	0.1	-0.4
Whole body water mass	0.1	0.4	0.8	-0.9	-0.5	0.7	0.1
Leg predicted mass (right)	0.1	0.3	0.4	0.3	0.5	0.6	0.6
Basal metabolic rate	0.1	0.4	0.9	-0.9	-0.6	0.5	-0.1
Cholesterol lowering medication	0.1	0.1	0.3	-0.0	-0.5	-0.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.5	-0.0	0.5
Smoking Status	0.0	0.1	0.1	0.3	0.2	0.3	0.1
Leg fat-free mass (left)	0.0	0.1	0.2	-0.1	0.2	0.3	0.4
Leg predicted mass (left)	0.0	0.1	0.2	-0.1	0.2	0.4	0.4
Leg fat-free mass (right)	0.0	0.2	0.3	0.2	0.5	0.5	0.5
Impedance of whole body	0.0	0.1	0.3	0.2	0.5	-0.3	0.3

Hub : Genes

IL1RL2

Models

Trait associations