TWAS hub - SLC22A12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0219	0.0145	0.0031	0.024	0.017	0.000	NA	0.013	0.0010	0.0043	0.290	NA	0.011
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0530	0.0360	0.0063	0.018	0.032	0.022	NA	0.021	0.0310	0.0063	0.019	NA	0.023
3	TCGA	Brain Lower Grade Glioma	0.0364	0.0285	0.0043	0.023	0.008	0.002	NA	0.006	0.0011	0.0330	0.160	NA	0.055

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Gout (self-reported)	60.9	83.6	110.2	10.5	10.0	6.4
Medication: Allopurinol	40.6	54.0	74.7	8.6	8.0	4.8
Ever smoked	10.0	17.6	22.0	4.0	4.7	3.9
Serious illness, injury or assault of a close relative in last 2 years	7.4	8.5	11.0	2.4	3.0	3.3
BMI	5.8	33.7	40.7	-5.5	-6.4	-5.5
Leg fat percentage (right)	5.4	19.7	26.1	-4.4	-5.1	-3.7
Leg fat percentage (left)	5.4	19.4	25.5	-4.4	-5.0	-3.6
Smoking Status	4.9	11.7	14.5	3.0	3.8	3.4
Body mass index (BMI)	4.5	19.0	25.4	-4.1	-5.0	-3.8
Illness, injury, bereavement, stress in last 2 years	4.3	5.3	6.1	-2.0	-2.5	-2.4
Qualifications: CSEs or equivalent	4.2	5.5	5.8	2.2	2.4	2.4
Leg fat mass (right)	4.1	15.8	21.6	-3.8	-4.7	-3.4
Past tobacco smoking	4.0	7.3	10.0	-2.5	-3.2	-2.4
Hip circumference	4.0	17.2	27.3	-3.3	-5.2	-3.7
Leg fat mass (left)	3.9	15.1	20.8	-3.6	-4.6	-3.4
Medication: Amlodipine	3.4	4.8	6.2	2.2	1.8	2.5
Wears glasses or contact lenses	3.4	3.9	4.6	-1.7	-2.1	-2.0
Depression (Nagel 2018)	3.3	5.0	5.6	2.4	2.3	2.0
Frequency of depressed mood in last 2 weeks	3.3	4.6	5.6	2.4	2.2	1.9
Whole body fat mass	3.2	13.4	20.3	-3.2	-4.5	-3.1
Average weekly beer plus cider intake	3.2	4.6	7.9	1.7	2.8	1.7
Body fat percentage	3.1	12.3	18.7	-3.1	-4.3	-2.9
Arm fat mass (right)	2.9	11.8	18.6	-2.9	-4.3	-2.9
Loud music exposure frequency	2.9	3.2	4.8	2.2	1.9	1.0
Guilty feelings	2.9	4.4	6.4	2.5	2.1	1.5
Hayfever, allergic rhinitis or eczema	2.7	6.0	8.3	2.4	2.9	1.9
Arm fat percentage (right)	2.7	10.8	17.6	-2.9	-4.2	-2.5
Ever highly irritable/argumentative for 2 days	2.7	3.2	5.5	1.5	1.4	2.4
Smoking status: Previous	2.7	4.0	4.9	2.0	2.2	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.7	6.9	-2.6	-2.3	-2.2
Arm fat mass (left)	2.7	11.2	17.6	-2.8	-4.2	-2.8
Waist circumference	2.6	9.4	12.9	-2.7	-3.6	-2.8
Hearing difficulty/problems with background noise	2.5	4.0	5.3	1.5	2.3	2.1
Arm fat percentage (left)	2.5	10.0	16.5	-2.8	-4.1	-2.5
Back pain experienced in last month	2.5	3.6	5.3	1.9	2.3	1.4
Breast cancer (self-reported)	2.5	2.9	4.1	1.6	1.5	2.0
Neuroticism (2016)	2.4	3.5	3.6	1.8	1.9	1.9
Multivitamins +/- minerals	2.4	3.1	3.9	1.6	2.0	1.7
Trunk fat mass	2.4	10.4	17.1	-2.7	-4.1	-2.6
Impedance of arm (left)	2.4	11.2	13.5	3.7	2.8	3.5
Leg pain on walking	2.4	3.0	4.2	-1.4	-1.6	-2.0
Ever had prostate specific antigen (PSA) test	2.4	2.8	4.8	2.2	1.5	1.2
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	4.9	1.7	2.2	0.9
Trunk fat percentage	2.2	8.9	14.7	-2.5	-3.8	-2.4
Bipolar Disorder (2018)	2.1	3.4	5.7	1.4	1.5	2.4
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	3.9	2.0	1.9	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.3	4.0	1.6	2.0	1.8
Diabetes (mother)	2.0	2.6	2.8	-1.6	-1.5	-1.7
Shortness of breath walking on level ground	2.0	2.4	3.3	-1.2	-1.6	-1.8
Emphysema/chronic bronchitis	2.0	2.3	3.5	-1.9	-1.4	-1.2
Average weekly champagne plus white wine intake	2.0	2.7	4.0	2.0	1.1	1.7
Allergy or Eczema	1.9	5.0	5.5	2.2	2.3	2.1
Hand grip strength (left)	1.9	5.0	7.6	2.8	1.9	2.0
Weight	1.9	9.5	15.4	-2.5	-3.9	-2.6
Impedance of arm (right)	1.9	9.1	10.6	3.3	2.6	3.2
Time employed in main current job	1.9	2.2	5.2	2.3	0.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.1	1.4	1.1	2.0
Medication: Atorvastatin	1.9	2.3	3.9	1.3	2.0	1.2
Alzheimer’s Disease (in father)	1.8	2.0	3.2	1.3	1.8	1.1
Schizophrenia (2014)	1.7	3.7	5.1	1.4	2.3	2.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.1	1.8	0.6	1.4
Impedance of whole body	1.7	8.8	9.3	3.0	2.9	2.9
Happiness	1.6	1.9	2.7	1.5	1.6	1.0
Pulse wave reflection index	1.6	1.9	2.8	-1.4	-1.1	-1.7
Mean time to correctly identify matches	1.6	3.1	4.0	-2.0	-1.3	-1.9
Pack years of smoking	1.6	2.3	3.8	-1.4	-1.1	-2.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.4	1.0	1.9	0.8
Vitamin and mineral supplements	1.5	2.0	3.0	-1.2	-1.7	-1.3
Hand grip strength (right)	1.5	4.0	6.1	2.5	1.6	1.8
Lung cancer (father)	1.5	1.8	3.2	1.0	1.1	1.8
Commuting to job workplace: Car/motor vehicle	1.5	1.7	1.8	-1.3	-1.2	-1.3
Qualifications: nursing, teaching	1.5	2.3	3.0	1.7	1.3	1.5
Medication: Blood pressure	1.5	2.9	4.6	1.3	1.5	2.1
Birth weight of first child	1.4	2.6	4.2	-2.1	-1.9	0.0
Angina	1.3	1.7	2.1	-1.4	-1.3	-1.2
Medication: Co-codamol	1.3	1.5	2.2	1.1	1.1	1.5
Maternal smoking around birth	1.3	1.9	2.4	1.5	1.3	1.3
Nervous feelings	1.3	2.3	3.7	1.4	1.2	1.9
Allergy	1.3	3.0	4.9	-1.8	-2.2	-0.9
Exposure to tobacco smoke outside home	1.3	1.7	3.0	-1.7	-0.9	-1.2
Family relationship satisfaction	1.3	1.5	2.3	1.5	1.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	2.6	-1.0	-1.1	-1.6
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.4	1.5	1.0	1.2
Fed-up feelings	1.2	2.3	3.0	1.7	1.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.4	1.4	1.6	0.5
Taking other prescription medications	1.2	1.8	2.5	1.6	1.6	0.6
Hair/balding pattern: Pattern 3	1.2	1.7	3.1	1.3	1.7	0.6
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.6	1.8	1.9	0.4
Health satisfaction	1.2	1.6	2.1	-0.9	-1.4	-1.4
Heart disease (mother)	1.2	1.5	2.3	1.4	1.5	0.5
Illnesses of father: Heart disease	1.2	1.6	2.3	-1.4	-0.8	-1.5
Eye problems/disorders: Cataract	1.2	1.4	2.0	-1.4	-1.1	-1.0
Systolic Blood Pressure	1.1	5.3	7.8	1.7	2.8	2.2
Pack years adult smoking proportion	1.1	1.7	3.0	-1.2	-0.8	-1.7
Alcohol usually taken with meals	1.1	1.7	2.9	-1.4	-1.7	-0.7
Illnesses of siblings	1.1	1.6	1.8	1.2	1.2	1.3
Noisy workplace	1.1	1.3	1.9	1.4	1.3	0.6
Tense / ‘highly strung’	1.1	1.8	3.3	1.1	0.8	1.8
Commuting to job workplace: Walk	1.1	1.2	1.5	0.9	1.2	1.1
High cholesterol (Self-reported)	1.1	1.9	2.2	1.5	1.2	1.5
Cholesterol lowering medication	1.1	1.6	2.8	1.0	1.7	1.0
Body Mass Index (BMI) (2010)	1.0	1.3	1.5	-1.2	-1.1	-1.1
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.1	-0.9	-1.4	-1.0
Impedance of leg (left)	1.0	4.7	5.9	1.9	2.4	2.1
Medication: Lansoprazole	1.0	1.2	2.0	-0.9	-1.4	-0.8
Forced vital capacity (FVC), Best measure	1.0	3.6	4.0	2.0	1.7	1.9
Worry too long after embarrassment	1.0	1.7	2.0	1.2	1.4	1.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.9	-0.9	-0.9	-1.4
Illnesses of father: High blood pressure	1.0	1.2	1.9	0.7	1.1	1.4
Fractured/broken bones in last 5 years	1.0	1.3	2.9	1.7	0.9	0.4
Ever depressed for a whole week	1.0	1.3	1.9	0.7	1.1	1.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	0.8	1.7	-0.0
Bipolar Disorder or Schizophrenia	0.9	2.3	3.3	0.9	1.6	1.8
Worry (Nagel 2018)	0.9	1.9	3.0	1.4	0.9	1.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.8	-1.3	-0.7	-0.8
Hypothyroidism (self reported)	0.9	2.1	3.3	1.8	1.8	0.1
Impedance of leg (right)	0.9	4.2	4.9	1.9	2.2	2.0
Financial difficulties in last 2 years	0.9	1.2	1.4	1.1	1.2	1.0
Illnesses of mother	0.9	1.1	2.7	-0.6	-1.6	-0.5
Blood clot in the leg (DVT)	0.9	1.2	1.8	-0.7	-1.1	-1.3
Osteoporosis (self-reported)	0.9	1.2	1.5	-1.2	-0.7	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.2	2.3	1.5	0.1	1.1
Prostate Cancer	0.8	1.1	1.8	-1.1	-1.4	-0.4
Coronary Artery Disease (CAD)	0.8	0.9	2.2	-0.6	-0.4	-1.5
Waist Hip Ratio (WHR)	0.8	3.4	5.9	1.4	2.4	1.5
Cardiovascular Disease	0.8	2.6	3.9	1.3	1.4	2.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	1.8	1.3	1.4	1.0
Current tobacco smoking	0.8	1.2	1.6	0.8	1.2	1.2
Chronic bronchitis/emphysema (father)	0.8	0.9	1.4	-1.1	-0.3	-1.2
Number of incorrect matches in round	0.8	1.3	2.0	-0.8	-1.2	-1.4
Had menopause	0.8	1.1	1.9	-0.8	-1.4	-0.8
Pain all over the body in last month	0.8	0.9	1.6	-0.5	-0.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	2.0	1.4	1.4	0.3
Exposure to tobacco smoke at home	0.8	0.9	2.0	-0.6	-0.6	-1.4
Angina (self-reported)	0.8	1.1	1.4	-1.2	-0.9	-1.0
Medication: Seretide 50 evohaler	0.8	1.0	1.0	-1.0	-0.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	-0.7	-0.2	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.7	0.7	0.5	1.3
Number of self-reported non-cancer illnesses	0.8	1.4	2.5	1.1	1.6	0.7
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	-1.0	-1.4	-0.3
Arm fat-free mass (left)	0.8	3.9	6.1	-1.6	-2.5	-1.7
Blood White Count	0.7	5.5	8.0	2.8	2.3	1.8
Hearing difficulty/problems: Yes	0.7	1.0	1.1	1.0	1.0	1.0
Medication for hormone replacement therapy	0.7	0.8	1.5	-0.3	-1.2	-0.9
Supplements: Zinc	0.7	0.8	1.3	0.6	1.1	0.8
Alcohol intake versus 10 years previously	0.7	1.0	2.3	0.9	1.5	-0.1
Worrier / anxious feelings	0.7	1.2	2.6	0.6	0.8	1.6
Standing height	0.7	6.7	10.8	3.3	1.9	2.4
Number of full brothers	0.7	0.9	1.1	-0.9	-1.1	-0.9
Number of children fathered	0.7	0.8	1.7	0.7	0.3	1.3
Alcohol intake frequency.	0.7	1.6	3.6	-0.5	-0.9	-1.9
Age at last live birth	0.7	1.0	1.7	1.3	0.7	0.9
Supplements: Vitamin C	0.7	0.8	1.6	0.7	1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.9	-1.4	-0.4	-1.1
Osteoarthritis (self-reported)	0.7	0.9	1.7	-0.4	-1.3	-1.0
Medication: Gliclazide	0.7	0.8	1.2	0.9	1.1	0.7
Mother’s age at death	0.7	0.9	1.8	0.9	1.4	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	-1.1	-0.0	-1.1
Medication: Paracetamol	0.7	1.1	2.2	-1.1	-1.5	-0.3
Arm predicted mass (left)	0.7	3.8	6.5	-1.5	-2.5	-1.6
Reaction Time	0.6	1.1	1.6	-1.0	-0.7	-1.3
Ovarian Cancer	0.6	0.8	1.3	0.8	1.1	0.7
Townsend deprivation index at recruitment	0.6	0.8	2.2	0.6	1.5	-0.1
High blood pressure (mother)	0.6	0.8	1.5	0.6	0.8	1.2
Leg predicted mass (left)	0.6	2.9	6.1	-1.0	-2.5	-1.3
Hair/balding pattern: Pattern 2	0.6	0.8	0.9	-0.9	-0.8	-0.9
Neuroticism score	0.6	1.3	2.5	1.0	0.7	1.6
Length of working week for main job	0.6	0.7	1.7	-0.4	-0.4	-1.3
High blood pressure (siblings)	0.6	0.8	1.6	-0.9	-1.3	-0.3
Medication: Ibuprofen	0.6	0.7	1.0	-0.7	-1.0	-0.8
Illnesses of siblings: Diabetes	0.6	0.7	0.9	-1.0	-1.0	-0.5
Smoking status: Current	0.6	0.9	1.4	0.6	1.2	0.9
Financial situation satisfaction	0.6	0.7	1.1	1.0	1.0	-0.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.5	-1.6	-1.4	-0.5
HDL Cholesterol	0.5	0.9	1.8	1.3	0.0	0.9
Triglycerides	0.5	0.8	1.1	-1.1	-0.7	-0.9
Blood Eosinophil Count	0.5	3.7	6.1	2.5	1.7	1.4
Neuroticism	0.5	1.3	2.7	0.8	0.7	1.7
Leg fat-free mass (left)	0.5	2.7	5.6	-0.9	-2.4	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	0.3	0.9	-1.0
Falls in the last year	0.5	0.7	1.0	-0.5	-1.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.4	1.6	0.9	0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	1.7	-1.3	-0.3	-0.9
Depression (self-reported)	0.5	0.5	0.8	0.6	0.9	0.7
Peak expiratory flow (PEF)	0.5	1.1	2.0	1.4	0.3	1.2
Headache pain in last month	0.5	0.9	1.1	0.9	0.9	1.0
Comparative body size at age 10	0.5	1.3	2.2	-1.5	-1.0	-0.9
Neck or shoulder pain in last month	0.5	0.7	1.1	1.0	0.9	0.6
Comparative height size at age 10	0.5	2.7	5.3	2.3	0.8	1.5
Number of full sisters	0.5	0.6	1.6	0.5	-0.0	1.3
Knee pain experienced in last month	0.5	0.8	1.3	-0.9	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.2	1.5	0.8	-0.1
Long-standing illness, disability or infirmity	0.5	0.8	1.5	0.8	1.2	-0.4
Ever had bowel cancer screening	0.5	0.5	0.9	-0.6	-0.6	-0.9
Medication for cholesterol	0.5	0.8	1.0	-0.9	-1.0	-0.7
Hearing aid user	0.5	0.6	0.9	0.8	0.9	0.5
Commuting to job workplace: Public transport	0.5	0.6	1.0	0.9	0.0	1.0
Basal metabolic rate	0.5	2.6	5.4	-1.0	-2.3	-1.2
Diastolic blood pressure, automated reading	0.5	1.5	1.8	1.3	1.2	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	0.9	-0.6	-0.9	-0.9
Alcohol drinker status: Previous	0.5	0.5	0.7	-0.8	-0.5	-0.8
Neuroticism (Nagel 2018)	0.4	0.8	1.6	0.7	0.6	1.3
Major Depression (MDD)	0.4	0.4	0.7	0.9	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.5	-0.7	-1.6	-0.4
Crohns Disease (2012)	0.4	0.7	1.1	-0.7	-1.0	-0.7
Primary Biliary Cirrhosis	0.4	0.6	0.9	-0.6	-0.9	-0.8
Heel T-Score	0.4	3.5	5.7	-1.5	-1.6	-2.4
Medication: Metformin	0.4	0.5	1.2	-0.3	-0.5	-1.1
Relative age voice broke	0.4	0.6	0.8	-0.7	-0.9	-0.6
High blood pressure	0.4	1.1	2.4	0.5	0.8	1.6
Forced vital capacity (FVC)	0.4	1.5	2.1	1.2	1.0	1.4
Qualifications: None of the above	0.4	1.0	2.6	-0.4	-0.3	-1.6
Mouth/teeth dental problems	0.4	0.6	1.6	1.3	-0.2	0.1
Heart attack	0.4	0.5	1.0	-0.6	-0.5	-1.0
Father’s age at death	0.4	0.5	0.8	0.3	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.2	1.3	0.6	1.5
Arm fat-free mass (right)	0.4	1.9	3.4	-1.0	-1.8	-1.1
Age at first live birth	0.4	0.7	1.2	0.9	0.1	1.1
Eye problems/disorders: None of the above	0.4	0.4	1.2	-0.2	-0.3	-1.1
Arm predicted mass (right)	0.4	2.2	3.8	-1.1	-1.9	-1.3
Hypertension (Self-reported)	0.4	1.1	1.9	0.6	1.0	1.4
Mineral and other dietary supplements	0.4	0.5	1.3	0.4	-0.2	-1.1
Alcohol drinker status: Never	0.4	0.4	0.6	-0.4	-0.7	-0.8
Number of operations (self-reported)	0.4	0.6	1.5	-0.1	-0.6	-1.2
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	-0.4	-0.1	-0.9
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.3	1.0	-0.5
Rheumatoid Arthritis	0.3	0.4	0.6	0.6	-0.2	0.8
Average weekly spirits intake	0.3	0.4	0.9	-0.4	-0.3	-0.9
Severe depression (siblings)	0.3	0.3	0.5	-0.5	-0.7	-0.6
Sitting height	0.3	2.4	3.4	1.8	1.2	1.6
Medication: Ramipril	0.3	0.4	1.1	-0.3	-1.1	-0.3
Fluid intelligence score	0.3	0.6	1.3	-0.0	-0.8	1.1
Prospective memory result	0.3	0.3	0.4	-0.5	-0.7	-0.5
Breastfed as a baby	0.3	0.4	0.6	0.8	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	-0.8	-0.8	-0.4
Glaucoma (self-reported)	0.3	0.3	0.6	0.3	-0.5	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.7	0.8	0.5	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.1	-0.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	0.8	0.5	0.4
Whole body fat-free mass	0.3	1.6	3.6	-0.7	-1.9	-0.9
Leg fat-free mass (right)	0.3	1.7	4.0	-0.6	-2.0	-0.9
Leg predicted mass (right)	0.3	1.6	3.7	-0.5	-1.9	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.3	0.4	0.9
Medication: Bendroflumethiazide	0.3	0.4	1.0	-1.0	-0.2	0.4
Irritability	0.3	0.6	0.8	0.9	0.3	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.6	-0.3	-0.8
Heart disease (siblings)	0.3	0.4	0.6	0.3	0.7	-0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.6	-0.1	-0.5
HbA1C	0.2	0.2	0.2	-0.4	-0.5	0.4
Ulcerative Colitis	0.2	0.3	0.4	-0.6	-0.7	0.0
Number of treatments/medications taken	0.2	0.3	0.6	0.7	0.7	0.1
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.6	-0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.6	0.4	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.5	0.4	0.4
Supplements: Glucosamine	0.2	0.2	0.3	-0.5	-0.4	0.4
Medication: Atenolol	0.2	0.3	0.3	0.5	0.6	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.7	0.5	-0.5
Trunk fat-free mass	0.2	1.0	2.2	-0.5	-1.5	-0.6
Pulse rate	0.2	0.4	0.7	0.5	-0.3	0.8
Trunk predicted mass	0.2	1.1	2.6	-0.6	-1.6	-0.7
Medication: Omeprazole	0.2	0.2	0.3	0.3	0.6	0.4
Overall health rating	0.2	0.4	0.7	0.3	0.8	0.7
Chest pain or discomfort	0.2	0.2	0.6	0.1	-0.2	-0.8
Had major operations	0.2	0.2	0.6	-0.0	0.2	-0.8
Diabetes diagnosed by doctor	0.2	0.3	0.9	-0.3	-0.2	-0.9
Friendships satisfaction	0.2	0.3	0.6	0.7	-0.3	0.3
Whole body water mass	0.2	1.2	2.8	-0.5	-1.7	-0.8
Medication: Lisinopril	0.2	0.3	0.6	0.4	0.4	0.8
Age started oral contraceptive pill	0.2	0.2	0.6	-0.7	0.2	-0.3
Myopia	0.2	0.2	0.6	0.3	0.2	0.8
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.4	-0.0	-0.5	-1.2
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.4	-0.5	0.1
Schizophrenia (2018)	0.1	0.3	0.7	-0.0	0.8	0.4
Crohns Disease (2017)	0.1	0.3	0.5	0.7	0.6	-0.1
Breast Cancer	0.1	0.1	0.3	0.3	-0.2	-0.6
Age at First Birth	0.1	0.2	0.4	0.4	0.6	0.2
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.3	-0.1	0.4
Mean Putamen Volume	0.1	0.1	0.3	0.2	0.2	0.5
Fasting Glucose	0.1	0.1	0.1	-0.4	-0.2	-0.1
LDL Cholesterol	0.1	0.2	0.6	-0.0	0.3	0.8
Height	0.1	1.9	4.0	2.0	0.9	1.0
Lung FEV1/FVC ratio	0.1	0.4	1.1	-0.1	-1.0	-0.1
Chronotype (morning person)	0.1	0.3	0.4	0.4	-0.5	-0.6
Tanning	0.1	1.4	1.9	1.0	1.2	1.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.1	0.6	0.1
Systolic blood pressure, automated reading	0.1	0.4	0.6	-0.6	0.4	-0.7
Diabetes (father)	0.1	0.1	0.3	-0.3	-0.2	-0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	0.3	-0.5	-0.5
Had other major operations	0.1	0.2	0.5	0.7	0.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.2	0.2	0.5
Diabetes (self-reported)	0.1	0.1	0.4	-0.1	0.2	-0.6
Medication: Simvastatin	0.1	0.1	0.3	0.6	-0.1	0.2
Number of live births	0.1	0.2	0.4	0.2	-0.7	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.8	0.4	-0.1	0.9
Asthma	0.1	0.3	0.4	0.4	0.7	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.2	0.5	0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.6	0.3	0.1
Medication: Paracetamol	0.1	0.2	0.6	-0.1	-0.2	0.8
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.2	-0.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.1	-0.5	0.2
Pulse wave peak to peak time	0.1	0.2	0.3	0.1	0.3	0.6
Qualifications: College or University degree	0.1	0.2	0.7	0.8	-0.2	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.5	0.5	-0.4
Migraine (self-reported)	0.1	0.1	0.4	-0.6	-0.1	-0.0
Pulse rate, automated reading	0.1	0.2	0.2	0.4	-0.5	0.5
Medication: Aspirin	0.1	0.1	0.1	-0.3	0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.2	-0.3	0.3
Average weekly red wine intake	0.1	0.1	0.2	-0.2	-0.0	0.5
Mood swings	0.1	0.2	0.5	0.1	0.4	0.7
Loneliness, isolation	0.1	0.1	0.3	-0.2	-0.5	0.2
Asthma (self-reported)	0.1	0.1	0.2	0.4	0.4	-0.3
Medication: Aspirin	0.1	0.1	0.1	-0.3	0.2	0.3
Miserableness	0.1	0.2	0.5	-0.0	0.1	-0.7
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.3	0.2	-0.5
Unable to work because of sickness or disability	0.1	0.2	0.3	0.2	0.6	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.1	-0.3	-0.3
Pain experienced in last month	0.1	0.1	0.1	-0.4	-0.2	-0.2
Supplements: Calcium	0.1	0.1	0.3	-0.5	0.1	-0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.2	0.2	-0.1
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.2	-0.4	-0.0
Lupus	0.0	0.0	0.1	-0.1	0.0	0.4
Blood Platelet Count	0.0	0.4	1.1	1.1	-0.2	0.1
Blood Red Count	0.0	0.1	0.3	0.6	0.0	0.2
Respiratory disease	0.0	0.1	0.1	0.3	0.1	-0.3
Lung FVC	0.0	0.1	0.1	-0.4	0.3	-0.2
Hair Pigment	0.0	0.2	0.3	-0.5	-0.4	-0.6
Relative age of first facial hair	0.0	0.0	0.1	-0.2	0.2	0.1
Average weekly fortified wine intake	0.0	0.0	0.0	0.0	-0.0	-0.2
Age when periods started (menarche)	0.0	0.1	0.1	0.4	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	-0.2	-0.1	-0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.3	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.3	0.2	-0.0
Medication: Cholesterol lowering	0.0	0.1	0.2	0.5	-0.1	-0.1
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	0.2	-0.2	-0.3
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	-0.1	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.3	0.2	0.3
Birth weight	0.0	0.1	0.2	0.5	0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.2	0.1	0.1
Medication: Blood pressure	0.0	0.1	0.2	0.4	0.1	-0.1
Suffer from ‘nerves’	0.0	0.1	0.2	-0.0	-0.0	0.4
Risk taking	0.0	0.0	0.1	0.2	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.1	0.2	0.3

Hub : Genes

SLC22A12

Models

Trait associations