TWAS hub - SLC22A11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Ovarian Serous Cystadenocarcinoma	0.0600	0.0330	0.00120	0.032	0.039	0.017	NA	0.033	0.00290	0.00120	0.0220	NA	0.0026
2	TCGA	Prostate Adenocarcinoma	0.0535	0.0295	0.00380	0.026	0.009	0.003	NA	0.021	0.00086	0.03700	0.1400	NA	0.0028
3	TCGA	Thyroid Carcinoma	0.0430	0.0250	0.00093	0.011	0.028	0.027	NA	0.025	0.02700	0.00085	0.0012	NA	0.0015

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Gout (self-reported)	55.6	76.2	100.0	-10.0	-9.4	-6.3
Medication: Allopurinol	35.8	47.6	67.1	-8.2	-7.5	-4.4
Ever smoked	5.3	9.4	13.0	-3.4	-1.9	-3.6
Guilty feelings	4.0	6.0	8.7	-2.9	-2.5	-1.7
Time employed in main current job	3.2	3.7	5.6	-2.3	-2.4	-0.2
Heart disease (mother)	3.0	3.6	7.3	-1.6	-2.7	-1.0
Birth weight of first child	2.8	5.0	9.8	3.1	2.3	-0.2
Mean time to correctly identify matches	2.7	5.1	9.8	2.1	1.2	3.1
Emphysema/chronic bronchitis	2.6	3.0	4.9	2.2	0.6	1.9
Illnesses of father: None of the above (group 1)	2.6	3.3	4.5	-2.1	-1.9	-1.2
Average weekly champagne plus white wine intake	2.6	3.6	4.9	-2.2	-1.4	-1.9
Pain type(s) experienced in last month: Hip pain	2.5	3.1	4.7	-1.7	-2.2	-1.4
Hypothyroidism (self reported)	2.4	5.6	11.8	-2.1	-3.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	4.7	-0.6	1.7	-2.2
Ever highly irritable/argumentative for 2 days	2.3	2.8	7.4	-0.8	0.5	-2.7
Medication: Bendroflumethiazide	2.3	3.5	6.2	2.5	2.0	0.6
Mineral and other dietary supplements	2.2	2.9	6.2	-1.6	-2.5	0.5
Fractured/broken bones in last 5 years	2.2	2.8	5.9	-2.4	-1.6	-0.1
Hypothyroidism/myxoedema (self-reported)	2.1	4.1	7.8	-1.9	-2.8	-0.9
Shortness of breath walking on level ground	2.1	2.5	5.7	1.1	0.8	2.4
Supplements: Glucosamine	2.0	2.6	5.0	1.5	2.2	0.6
Lung cancer (father)	2.0	2.3	5.5	-0.7	-1.0	-2.4
Peak expiratory flow (PEF)	2.0	4.7	6.4	-2.4	-1.5	-2.5
Loud music exposure frequency	2.0	2.2	3.4	-1.9	-1.8	-0.0
HDL Cholesterol	1.9	3.2	4.8	-2.2	-1.0	-2.0
Type 2 Diabetes (T2D) (2012)	1.9	2.2	3.8	1.4	1.9	0.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.3	-1.8	-1.4	-0.9
Hayfever, allergic rhinitis or eczema	1.9	4.1	5.3	-2.3	-1.4	-2.3
Happiness	1.9	2.4	3.4	-1.6	-1.8	-1.1
Length of working week for main job	1.9	2.1	4.9	0.2	-1.1	2.2
Long-standing illness, disability or infirmity	1.9	3.0	6.5	-1.2	-2.5	0.9
Hand grip strength (left)	1.8	4.6	6.9	-2.6	-1.5	-2.2
Smoking Status	1.7	4.2	8.1	-1.9	-0.8	-2.8
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.1	-1.7	-1.7	-0.8
Chronic bronchitis/emphysema (father)	1.7	2.0	2.7	1.5	1.0	1.6
High blood pressure (mother)	1.7	2.4	6.1	-1.0	-0.3	-2.5
Allergy	1.7	3.8	5.6	2.1	2.4	1.3
Alcohol intake versus 10 years previously	1.7	2.5	5.8	-1.1	-2.4	-0.6
Number of children fathered	1.7	2.0	5.1	-0.7	-0.5	-2.3
Wears glasses or contact lenses	1.7	1.9	3.8	1.3	0.5	1.9
Taking other prescription medications	1.5	2.3	4.0	-1.3	-2.0	-1.0
Past tobacco smoking	1.5	2.7	3.7	1.9	1.1	1.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.9	-1.4	-2.2	0.7
Impedance of arm (left)	1.5	7.1	11.4	-3.4	-1.0	-3.0
Leg fat percentage (right)	1.5	5.3	11.8	3.4	1.4	1.4
Financial situation satisfaction	1.5	1.8	3.2	-1.4	-1.8	0.6
High cholesterol (Self-reported)	1.5	2.6	5.2	-1.4	-0.9	-2.3
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.1	-1.8	-1.3	-0.6
BMI	1.4	8.3	12.7	3.6	0.6	3.4
Allergy or Eczema	1.4	3.8	7.2	-1.9	-0.9	-2.7
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.1	-1.8	-1.4	-0.9
Medication: Co-codamol	1.4	1.6	3.3	-1.3	-0.1	-1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.1	6.0	-2.4	-1.6	-0.9
Pulse wave reflection index	1.4	1.7	3.4	1.2	0.5	1.8
Exposure to tobacco smoke outside home	1.4	1.8	2.4	1.5	1.1	1.4
Leg fat percentage (left)	1.4	5.1	11.2	3.4	1.4	1.4
HbA1C	1.3	1.4	3.1	0.9	1.8	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.5	-0.8	-1.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.6	-1.9	-1.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	4.7	-2.2	-1.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	2.6	-0.8	1.0	-1.6
Commuting to job workplace: Cycle	1.3	1.6	4.7	0.2	-0.0	2.2
Basal cell carcinoma (self-reported)	1.3	1.6	2.8	-1.1	-1.7	0.8
Pack years of smoking	1.3	2.0	4.4	1.2	-0.2	2.1
Alzheimer’s Disease (in father)	1.2	1.3	1.6	-1.0	-1.2	-1.3
Prostate Cancer	1.2	1.7	3.2	1.8	1.2	0.7
Fasting Glucose	1.2	1.5	2.8	1.0	1.7	0.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.3	-0.8	-2.1	0.1
Medication: Simvastatin	1.2	1.8	3.3	-1.0	-1.1	-1.8
Forced vital capacity (FVC), Best measure	1.2	4.5	7.2	-2.7	-0.8	-2.4
Knee pain experienced in last month	1.2	1.8	2.9	1.7	0.9	1.3
Qualifications: nursing, teaching	1.2	1.9	2.8	-1.7	-0.5	-1.6
Mother’s age at death	1.2	1.4	2.7	-1.0	-1.6	0.8
Medication: Lisinopril	1.2	1.5	4.2	-0.6	0.2	-2.0
Sensitivity / hurt feelings	1.1	1.9	2.6	1.3	1.6	-1.2
Pack years adult smoking proportion	1.1	1.7	3.9	1.0	-0.4	2.0
Hand grip strength (right)	1.1	2.9	4.2	-2.0	-1.3	-1.7
Body mass index (BMI)	1.1	4.7	9.4	3.1	0.7	2.1
Mouth/teeth dental problems	1.1	1.7	2.3	-1.4	-1.5	0.9
Impedance of arm (right)	1.1	5.1	8.5	-2.9	-0.7	-2.5
Noisy workplace	1.1	1.4	2.1	-1.0	-1.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.7	5.9	-2.2	-0.3	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.6	-0.9	-0.8	-1.9
Reaction Time	1.0	1.9	5.0	0.8	0.0	2.2
Maternal smoking around birth	1.0	1.4	2.0	-1.4	-0.7	-1.4
Medication: Levothyroxine sodium	1.0	1.8	4.0	-1.2	-2.0	0.0
Number of incorrect matches in round	1.0	1.7	3.9	1.0	0.3	2.0
Blood clot in the leg (DVT)	1.0	1.3	2.1	0.6	-1.3	1.4
Comparative height size at age 10	1.0	5.3	7.6	-2.8	-2.2	-1.9
Age at last live birth	1.0	1.5	2.5	-1.4	-1.6	-0.3
Osteoporosis (self-reported)	1.0	1.2	1.6	1.3	0.8	1.2
Age started oral contraceptive pill	1.0	1.2	2.7	1.6	0.6	0.8
Heart disease (siblings)	1.0	1.2	2.8	-0.9	-1.7	-0.2
Depression (Nagel 2018)	0.9	1.4	2.1	-1.5	-1.2	-0.8
Ovarian Cancer	0.9	1.1	1.4	-1.2	-1.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.2	-1.0	-1.1	-0.8
Number of live births	0.9	1.2	2.8	-0.8	-0.6	-1.7
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.8	-1.1	-1.4	-0.4
Medication: Amlodipine	0.9	1.3	2.6	-0.9	-0.6	-1.6
Health satisfaction	0.9	1.2	2.4	1.0	-0.5	1.5
Number of full sisters	0.9	1.1	3.0	-0.2	0.4	-1.7
Smoking status: Previous	0.9	1.4	2.0	-1.4	-0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	2.6	1.4	1.6	1.0
Unable to work because of sickness or disability	0.9	1.2	2.3	-1.1	-1.5	-0.2
Ulcerative Colitis	0.8	1.1	2.1	1.0	1.4	-0.4
Blood Eosinophil Count	0.8	5.9	10.0	-3.2	-1.5	-2.4
Average weekly spirits intake	0.8	1.0	2.9	0.1	-0.4	1.7
Angina	0.8	1.0	1.4	1.1	1.2	0.6
Diabetes (father)	0.8	1.0	2.2	-0.7	-0.3	-1.5
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.6	-0.4	-1.3	-1.1
Had other major operations	0.8	1.0	1.5	-1.2	-1.2	0.2
Father’s age at death	0.8	1.1	1.7	-1.3	-1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	5.3	-1.5	0.3	-2.3
Mouth/teeth dental problems: Dentures	0.8	1.3	2.3	1.5	1.2	0.3
Standing height	0.8	7.9	15.8	-4.0	-1.9	-2.1
Migraine (self-reported)	0.8	0.9	1.5	1.2	1.1	0.3
Leg fat mass (right)	0.8	3.2	6.6	2.6	0.8	1.5
Illnesses of father: Heart disease	0.8	1.1	1.6	1.0	0.8	1.3
Commuting to job workplace: Public transport	0.8	0.9	1.5	-1.1	0.3	-1.2
Number of operations (self-reported)	0.8	1.1	2.0	-0.9	-1.4	0.7
Supplements: Calcium	0.8	0.8	1.7	0.9	1.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.5	0.8	-0.8	1.2
Impedance of whole body	0.8	4.3	6.9	-2.6	-0.6	-2.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	0.8	0.5	1.2
Major Depression (MDD)	0.7	0.9	1.5	-0.9	-0.5	-1.2
Coronary Artery Disease (CAD)	0.7	0.8	1.8	-0.5	-1.4	0.5
LDL Cholesterol	0.7	1.2	2.5	0.3	0.9	-1.6
Schizophrenia (2014)	0.7	1.5	3.9	-0.7	0.1	-2.0
Townsend deprivation index at recruitment	0.7	1.0	1.9	-0.5	-1.4	1.0
Alcohol usually taken with meals	0.7	1.2	1.8	1.2	1.3	0.5
Forced vital capacity (FVC)	0.7	2.9	5.0	-1.9	0.1	-2.2
Fluid intelligence score	0.7	1.5	3.0	0.4	1.1	-1.7
Hair/balding pattern: Pattern 3	0.7	1.0	1.8	-1.3	-1.0	-0.5
Comparative body size at age 10	0.7	1.8	4.0	2.0	0.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.3	-0.5	0.0	-1.5
Eye problems/disorders: None of the above	0.7	0.8	2.3	-0.1	-0.3	1.5
Chest pain or discomfort	0.7	1.1	1.6	-1.2	-1.2	0.4
Leg pain on walking	0.7	0.9	2.2	0.4	-0.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.0	1.4	0.8	0.1
Ever had bowel cancer screening	0.7	0.8	1.4	1.0	-0.3	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.4	0.7	1.1	1.2
Back pain experienced in last month	0.7	1.1	1.6	-1.3	-1.3	-0.1
Myopia	0.7	1.0	2.6	-0.3	0.6	-1.6
Cholesterol lowering medication	0.7	1.0	2.1	-0.8	-0.6	-1.5
Alcohol drinker status: Previous	0.7	0.8	1.1	1.0	1.0	0.3
Leg fat mass (left)	0.7	2.8	5.8	2.4	0.7	1.4
Blood Platelet Count	0.6	7.3	9.8	-2.7	-3.1	-2.2
Blood White Count	0.6	4.6	8.5	-2.9	-1.5	-1.8
Cardiovascular Disease	0.6	2.0	5.9	-0.4	-0.3	-2.4
Diabetes (mother)	0.6	0.7	1.1	0.9	0.5	1.0
Current tobacco smoking	0.6	0.9	2.5	-0.4	-0.4	-1.6
Multivitamins +/- minerals	0.6	0.8	1.6	-0.8	-0.3	-1.3
Had menopause	0.6	0.7	1.8	0.6	0.1	1.3
Pain all over the body in last month	0.6	0.6	1.3	-0.2	-1.1	0.7
Depression (self-reported)	0.6	0.7	1.7	-0.1	-0.5	-1.3
Illnesses of mother	0.6	0.7	1.7	0.6	1.3	0.3
Family relationship satisfaction	0.6	0.7	1.0	-1.0	-1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	-0.2	-0.8	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.5	0.5	-0.7	1.2
Breast cancer (self-reported)	0.6	0.7	1.9	-0.3	0.4	-1.4
Medication: Aspirin	0.6	0.8	1.6	1.3	0.7	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.9	0.8	0.6	1.0
Bipolar Disorder (2018)	0.5	0.8	1.9	0.2	0.6	-1.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.9	1.4	1.7	0.1
Bipolar Disorder (2011)	0.5	0.5	0.8	0.9	0.8	0.1
Triglycerides	0.5	0.8	1.4	1.2	0.5	0.8
Chronotype (morning person)	0.5	1.2	2.3	-0.8	-1.5	0.8
Number of treatments/medications taken	0.5	0.9	2.5	-0.1	-1.6	-0.5
Medication: Metformin	0.5	0.6	1.8	-0.3	-1.3	0.2
Fed-up feelings	0.5	0.9	1.3	-1.0	-1.1	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.1	-0.9	-0.5	-1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	0.8	-0.4	1.0
Exposure to tobacco smoke at home	0.5	0.6	1.1	-0.2	-0.8	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	0.6	1.2	0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	-1.1	-0.9	0.5
High blood pressure (siblings)	0.5	0.7	1.3	1.1	0.9	-0.0
Number of full brothers	0.5	0.6	1.1	1.1	0.4	0.7
Qualifications: College or University degree	0.5	1.5	2.9	-1.7	-1.2	0.1
Angina (self-reported)	0.5	0.7	0.9	0.9	0.9	0.6
Overall health rating	0.5	1.1	1.9	1.4	-0.3	1.1
Average weekly red wine intake	0.5	0.7	2.0	0.3	1.4	0.2
Friendships satisfaction	0.5	0.6	0.9	-0.9	-0.9	-0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.4	0.2	0.6	-1.2
Medication: Paracetamol	0.5	0.8	1.6	1.3	0.8	-0.4
Risk taking	0.5	0.7	2.0	0.2	-0.2	1.4
Ever depressed for a whole week	0.5	0.7	1.9	-0.1	0.3	-1.4
Bipolar Disorder or Schizophrenia	0.4	1.1	2.3	0.2	0.9	-1.5
Mean Putamen Volume	0.4	0.5	1.4	0.3	1.2	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.7	-0.5	0.9
Sitting height	0.4	2.5	5.3	-2.3	-0.7	-1.4
Impedance of leg (left)	0.4	1.9	3.3	-1.5	0.0	-1.8
Waist circumference	0.4	1.4	2.2	1.5	0.2	1.4
Arm fat percentage (right)	0.4	1.5	4.0	2.0	0.5	0.6
Pulse rate	0.4	0.6	1.1	-0.5	-0.7	-1.0
Asthma	0.4	0.8	1.7	-0.7	-1.3	0.3
Tense / ‘highly strung’	0.4	0.7	1.7	-0.4	0.5	-1.3
Medication: Paracetamol	0.4	0.6	0.7	0.7	0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	0.6	1.3	0.5
Glaucoma (self-reported)	0.4	0.5	1.3	-0.2	0.4	-1.1
Body fat percentage	0.4	1.5	3.7	1.9	0.4	0.8
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	-1.3	-0.4	0.5
Medication: Ibuprofen	0.4	0.4	0.9	1.0	0.0	0.6
Whole body fat mass	0.4	1.7	3.5	1.9	0.3	1.2
Had major operations	0.4	0.4	1.1	-0.5	-1.0	-0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	0.2	-1.1	0.5
Medication: Aspirin	0.4	0.5	1.3	1.1	0.5	0.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	1.2	0.5	-0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.3	-0.7	1.0
Smoking status: Current	0.4	0.6	1.7	-0.2	-0.4	-1.3
Hearing aid user	0.4	0.4	1.2	-0.3	-0.2	-1.1
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.7	1.0	-0.1
Average weekly beer plus cider intake	0.4	0.6	0.9	-0.9	-0.9	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	-0.3	0.2	1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	-0.6	-0.9	0.4
Breast Cancer	0.3	0.8	1.2	-1.0	-1.1	-0.4
Lupus	0.3	0.4	1.1	0.2	1.0	-0.1
Neuroticism (2016)	0.3	0.4	0.9	-0.9	-0.3	-0.6
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.2	-0.9	0.6
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.3	-0.8	0.5
Vitamin and mineral supplements	0.3	0.4	1.0	0.5	-0.1	1.0
Impedance of leg (right)	0.3	1.5	2.6	-1.3	0.2	-1.6
Serious illness, injury or assault to yourself	0.3	0.4	1.2	-0.0	0.1	1.1
High blood pressure	0.3	0.7	1.1	1.1	0.5	-0.9
Nervous feelings	0.3	0.6	1.6	-0.3	-0.1	-1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	0.0	0.0	-1.1
Qualifications: None of the above	0.3	0.6	1.0	0.0	-1.0	0.9
Illnesses of siblings	0.3	0.4	1.1	-1.0	0.3	-0.1
Hip circumference	0.3	1.5	3.4	1.0	-0.4	1.8
Worrier / anxious feelings	0.3	0.7	1.1	0.9	1.1	-0.4
Medication: Cholesterol lowering	0.3	0.4	0.8	-0.5	-0.9	-0.5
Arm fat mass (right)	0.3	1.3	2.9	1.7	-0.0	1.0
Hair/balding pattern: Pattern 4	0.3	0.6	0.8	0.7	0.7	0.9
Wheeze or whistling in the chest in last year	0.3	0.6	0.9	0.2	-0.9	1.0
Neck or shoulder pain in last month	0.3	0.5	0.7	-0.7	-0.9	0.4
Alcohol intake frequency.	0.3	0.8	1.8	-0.7	-1.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	1.0	-0.1	0.2
Arm fat percentage (left)	0.3	1.1	2.9	1.7	0.3	0.5
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.5	0.3	-0.8
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.9	0.1	0.4
Asthma (self-reported)	0.3	0.6	1.6	-0.6	-1.2	0.2
Medication: Gliclazide	0.3	0.4	0.6	-0.8	-0.7	-0.3
Arm fat mass (left)	0.3	1.2	2.7	1.6	-0.0	1.0
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	0.1	-1.1	-0.4
Miserableness	0.3	0.5	1.3	-0.1	-0.6	1.1
Medication: Atorvastatin	0.3	0.4	0.5	-0.6	-0.7	-0.5
Alcohol drinker status: Never	0.3	0.3	0.7	-0.2	-0.8	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	-1.3	-0.5	0.9
Pain experienced in last month	0.3	0.5	1.2	-0.5	0.3	-1.1
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	1.0	0.8	0.1
Schizophrenia (2018)	0.2	0.4	0.7	0.1	0.7	-0.9
Worry (Nagel 2018)	0.2	0.4	0.8	-0.6	-0.2	-0.9
Ulcerative Colitis (UC)	0.2	0.3	0.7	0.2	0.5	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.5	0.4	0.7
Crohns Disease (2012)	0.2	0.3	0.7	0.9	0.5	0.1
Height	0.2	3.1	7.0	-2.6	-1.3	-0.8
Respiratory disease	0.2	0.5	1.2	-0.4	-1.1	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.8	-0.2	-0.6
Relative age of first facial hair	0.2	0.4	0.8	0.5	0.9	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.7	0.1	0.6
Systolic blood pressure, automated reading	0.2	0.6	1.0	0.9	0.1	1.0
Severe depression (siblings)	0.2	0.2	0.5	0.1	-0.7	0.2
Average weekly fortified wine intake	0.2	0.3	0.3	-0.6	-0.5	-0.4
Relative age voice broke	0.2	0.4	0.7	0.4	0.6	0.8
Trunk fat mass	0.2	0.7	1.6	1.3	0.0	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.1	0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.7	-0.8	-0.2	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	-0.3	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.1	-0.7	0.3
Birth weight	0.2	0.4	1.0	-0.2	-0.4	1.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.1	-0.6	0.5
Worry too long after embarrassment	0.2	0.3	0.6	-0.8	0.4	-0.2
Pulse wave peak to peak time	0.2	0.2	0.3	-0.5	0.5	-0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.7	-0.2	0.4
Suffer from ‘nerves’	0.2	0.3	0.9	0.2	-0.2	-0.9
Hypertension (Self-reported)	0.2	0.5	1.0	0.7	-0.0	-1.0
Loneliness, isolation	0.2	0.2	0.4	0.7	-0.5	0.1
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.6	-0.7	0.1
Medication: Blood pressure	0.2	0.4	0.7	0.0	0.6	-0.9
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.0	0.7	-0.6
Irritability	0.2	0.3	0.5	-0.7	-0.5	-0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.0	-1.0	-0.6	-0.7
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.1	0.4	-0.8
Crohns Disease (2017)	0.1	0.3	0.4	-0.3	-0.6	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.2	0.6	-0.4
Age at First Birth	0.1	0.2	0.3	-0.5	-0.5	-0.1
Blood Red Count	0.1	1.4	2.7	-1.1	-0.7	-1.6
Heel T-Score	0.1	0.5	0.9	0.3	-0.6	1.0
Waist Hip Ratio (WHR)	0.1	0.3	0.8	-0.2	0.4	-0.9
Systolic Blood Pressure	0.1	0.3	0.7	-0.1	0.6	-0.8
Lung FEV1/FVC ratio	0.1	0.6	1.8	-0.2	-0.3	-1.4
Lung FVC	0.1	0.7	1.5	-0.7	-0.0	-1.2
Neuroticism	0.1	0.2	0.3	0.2	0.5	-0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.3	0.5	0.2
Supplements: Zinc	0.1	0.2	0.3	-0.3	0.2	-0.6
Trunk fat percentage	0.1	0.5	1.4	1.2	-0.1	0.4
Medication: Atenolol	0.1	0.1	0.2	-0.1	-0.1	-0.4
Diabetes (self-reported)	0.1	0.2	0.4	0.1	-0.5	0.6
Medication: Ramipril	0.1	0.1	0.2	0.4	0.3	0.3
Neuroticism score	0.1	0.2	0.7	-0.1	-0.1	-0.8
Weight	0.1	0.7	1.2	1.1	-0.1	1.0
Falls in the last year	0.1	0.2	0.3	-0.2	-0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	-0.5	-0.3
Medication: Lansoprazole	0.1	0.1	0.4	0.7	0.0	-0.1
Prospective memory result	0.1	0.1	0.3	0.6	0.1	0.2
Breastfed as a baby	0.1	0.1	0.1	-0.3	-0.4	0.2
Headache pain in last month	0.1	0.1	0.3	0.1	0.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.5	0.2	-0.4
Age at first live birth	0.1	0.2	0.6	-0.8	0.0	-0.3
Medication: Blood pressure	0.1	0.2	0.7	-0.0	-0.9	-0.0
Medication: Omeprazole	0.1	0.2	0.3	0.4	0.2	0.6
Pulse rate, automated reading	0.1	0.4	1.1	-0.2	-1.0	-0.4
Supplements: Vitamin C	0.1	0.2	0.2	-0.4	-0.3	-0.5
Mood swings	0.1	0.2	0.3	0.6	0.3	-0.5
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.2	-0.5	0.6
Medication for cholesterol	0.1	0.2	0.3	0.4	0.6	-0.0
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.0	-0.1	0.5
Arm fat-free mass (left)	0.1	0.6	1.1	0.8	-0.1	1.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	0.5	0.5	0.2
Arm predicted mass (left)	0.1	0.4	0.8	0.7	-0.2	0.9
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.1	0.1	-0.1
Rheumatoid Arthritis	0.0	0.0	0.1	-0.1	0.1	-0.3
Hair Pigment	0.0	0.1	0.2	0.1	0.4	0.2
Tanning	0.0	0.1	0.1	0.4	0.4	-0.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.0	-0.2	-0.1
Leg fat-free mass (left)	0.0	0.2	0.5	-0.1	-0.7	0.2
Age when periods started (menarche)	0.0	0.1	0.3	-0.0	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.0	0.1	-0.5
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.3	-0.1	0.2
Leg predicted mass (left)	0.0	0.2	0.6	-0.1	-0.8	0.3
Heart attack	0.0	0.0	0.1	0.1	-0.2	0.2
Trunk fat-free mass	0.0	0.0	0.1	-0.0	-0.2	0.3
Trunk predicted mass	0.0	0.0	0.1	0.0	-0.2	0.3
Arm fat-free mass (right)	0.0	0.2	0.4	0.3	-0.2	0.6
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.2	-0.1	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.2	-0.2	-0.0
Arm predicted mass (right)	0.0	0.2	0.4	0.4	-0.4	0.6
Whole body fat-free mass	0.0	0.1	0.2	-0.1	-0.4	0.2
Leg fat-free mass (right)	0.0	0.2	0.6	-0.4	-0.8	-0.0
Whole body water mass	0.0	0.2	0.4	-0.3	-0.7	0.1
Leg predicted mass (right)	0.0	0.3	0.6	-0.4	-0.8	-0.0
Basal metabolic rate	0.0	0.1	0.2	0.1	-0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	-0.1	-0.1

Hub : Genes

SLC22A11

Models

Trait associations