Best TWAS P=1.5e-46 · Best GWAS P=3.84e-51 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SIDT2 | 0.07 | 0.06 | lasso | 5 | 0.05 | 8.8e-07 | 5.36 | -6.0 | 1.6e-09 | -0.29 | 0.99 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNF259 | 0.08 | 0.03 | enet | 6 | 0.03 | 1.2e-04 | 11.22 | -14.3 | 1.5e-46 | -0.76 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | PAFAH1B2 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.3e-01 | 9.06 | -9.9 | 5.4e-23 | -0.42 | 0.06 | 0.22 | TRUE |
| 4 | GTEx | Colon Sigmoid | PCSK7 | 0.28 | 0.09 | lasso | 8 | 0.15 | 6.5e-06 | 9.31 | -7.1 | 9.2e-13 | -0.39 | 0.82 | 0.01 | TRUE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | PCSK7 | 0.20 | 0.05 | enet | 31 | 0.07 | 7.0e-05 | 4.28 | 5.2 | 1.7e-07 | 0.27 | 0.26 | 0.08 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | SIDT2 | 0.11 | 0.00 | enet | 13 | 0.01 | 9.0e-02 | 4.75 | -6.0 | 1.4e-09 | -0.21 | 0.14 | 0.07 | TRUE |
| 7 | GTEx | Testis | TAGLN | 0.15 | 0.05 | lasso | 5 | 0.04 | 8.0e-03 | 6.22 | -7.2 | 5.4e-13 | -0.32 | 0.36 | 0.03 | FALSE |
| 8 | GTEx | Whole Blood | SIDT2 | 0.18 | 0.06 | lasso | 7 | 0.04 | 2.3e-04 | 5.30 | -5.5 | 4.5e-08 | -0.24 | 0.95 | 0.00 | FALSE |
| 9 | METSIM | Adipose | SIDT2 | 0.09 | 0.07 | lasso | 7 | 0.07 | 2.3e-10 | 5.30 | -5.9 | 2.9e-09 | -0.30 | 1.00 | 0.00 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | PAFAH1B2 | 0.09 | 0.04 | lasso | 4 | 0.05 | 1.3e-06 | 4.28 | 5.2 | 2.3e-07 | 0.31 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | SIDT2 | 0.11 | 0.00 | blup | 46 | 0.05 | 8.2e-04 | 5.30 | -6.3 | 3.4e-10 | -0.25 | 0.01 | 0.51 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PCSK7 | 0.04 | 0.03 | lasso | 3 | 0.03 | 5.6e-04 | 5.36 | 5.6 | 1.7e-08 | 0.26 | 0.15 | 0.82 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SIDT2 | 0.08 | 0.01 | blup | 46 | 0.05 | 2.4e-06 | 6.23 | -6.7 | 1.7e-11 | -0.21 | 0.04 | 0.74 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BUD13 | 0.24 | 0.03 | blup | 76 | 0.08 | 1.8e-04 | 1.80 | -6.4 | 1.4e-10 | -0.25 | 0.03 | 0.05 | TRUE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | SIDT2 | 0.02 | 0.01 | blup | 46 | 0.01 | 4.6e-02 | 4.57 | -5.4 | 7.4e-08 | -0.26 | 0.03 | 0.49 | TRUE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SIK3 | 0.04 | 0.04 | enet | 8 | 0.03 | 5.2e-04 | 6.46 | 5.5 | 4.4e-08 | 0.38 | 0.74 | 0.01 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF259 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.4e-04 | 11.45 | -11.8 | 4.4e-32 | -0.48 | 0.19 | 0.08 | TRUE |
| 18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | BUD13 | 0.08 | 0.00 | blup | 76 | 0.01 | 9.2e-02 | -0.56 | -9.2 | 2.4e-20 | -0.22 | 0.02 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SIDT2 | 0.16 | 0.08 | enet | 10 | 0.04 | 1.2e-02 | -4.02 | -5.9 | 3.5e-09 | -0.20 | 0.03 | 0.12 | FALSE |