TWAS hub - PAFAH1B2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2990	0.1090	6.9e-03	0.030	NA	0.064	NA	0.040	4.6e-02	NA	6.0e-03	NA	2.4e-02
2	GTEx	Cells Transformed fibroblasts	0.1130	0.0510	9.4e-03	-0.004	NA	-0.003	NA	0.005	8.2e-01	NA	6.0e-01	NA	1.3e-01
3	METSIM	Adipose	0.0675	0.0233	6.4e-05	0.016	0.024	0.022	0.024	0.019	1.3e-03	1.5e-04	2.5e-04	1.2e-04	5.6e-04
4	NTR	Blood	0.0430	0.0119	1.7e-07	0.040	0.025	0.039	0.035	0.038	5.6e-13	1.2e-08	1.1e-12	2.2e-11	2.7e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.0947	0.0277	4.6e-06	0.038	0.041	0.035	0.044	0.046	9.7e-06	4.9e-06	2.5e-05	2.0e-06	1.3e-06
6	YFS	Blood	0.0146	0.0063	1.8e-03	0.016	0.008	0.011	0.009	0.013	3.9e-06	1.0e-03	1.2e-04	5.3e-04	3.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Triglycerides	53.8	88.1	320.4	-5.3	-17.9	4.7	5.5	9.0	-6.9
High cholesterol (Self-reported)	16.4	29.0	97.4	-3.3	-9.9	3.2	4.2	5.2	-3.5
Cholesterol lowering medication	10.2	15.0	44.5	-2.8	-6.7	0.9	2.7	4.1	-3.5
Medication: Cholesterol lowering	8.8	13.8	53.7	-2.7	-7.3	1.5	1.8	3.0	-2.6
Medication: Atorvastatin	8.4	10.4	37.6	-1.2	-6.1	1.3	2.7	3.2	-2.1
LDL Cholesterol	7.4	11.7	35.2	-2.7	-5.9	2.6	1.8	3.4	-2.6
Medication: Simvastatin	6.5	9.5	37.9	-2.6	-6.2	1.5	1.2	2.1	-2.0
Medication for cholesterol, blood pressure or diabetes	6.1	10.1	29.8	2.7	5.5	-0.4	-2.2	-3.6	2.4
HDL Cholesterol	4.8	7.9	17.3	-3.5	3.3	-4.2	0.8	2.2	-1.5
Cardiovascular Disease	4.4	14.6	50.6	-3.0	-7.1	0.4	1.1	3.2	-4.1
Illnesses of father: Heart disease	4.4	6.1	16.1	-0.4	-2.3	2.7	4.0	2.4	1.5
Medication: Gliclazide	4.1	4.7	8.7	-2.9	-2.9	-1.7	-1.8	-0.2	-2.2
Ovarian Cancer	4.0	5.3	17.0	-1.5	-0.7	-2.0	2.4	4.1	-1.5
Medication: Metformin	3.6	5.1	13.6	-3.7	-1.9	-2.1	-0.2	1.1	-2.8
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	7.9	-2.7	-0.2	-2.7	0.9	1.6	-2.8
Medication for cholesterol	3.4	5.2	15.0	1.8	3.9	1.6	0.2	-1.3	3.0
Time employed in main current job	3.3	3.8	8.6	-2.4	-1.9	-1.9	-0.1	1.0	-2.9
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	7.7	-0.8	-1.8	-2.4	-2.3	-0.5	-2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	9.9	0.7	1.4	-3.1	-2.5	-2.1	-0.3
Coronary Artery Disease (CAD)	3.2	3.8	10.5	-0.9	-3.2	2.3	2.0	1.6	0.0
Medication: Lansoprazole	3.1	3.5	8.5	-0.0	0.9	-1.7	2.7	2.9	-1.2
Alzheimer’s Disease (including proxy)	3.0	4.3	9.6	-2.8	-2.1	-1.3	-0.9	1.2	-3.1
Illnesses of mother	3.0	3.7	8.8	3.0	2.5	0.5	0.2	-0.9	2.5
Commuting to job workplace: Cycle	3.0	3.6	7.3	-0.7	0.8	2.5	2.7	2.3	1.4
Alzheimer’s Disease (in mother)	2.8	3.3	6.1	-2.5	-2.4	-0.4	0.1	1.3	-2.4
Ulcerative Colitis (UC)	2.8	5.2	12.0	0.8	2.5	-0.6	-3.4	-3.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.1	5.3	-1.7	0.3	-2.3	1.9	2.0	-1.8
Ulcerative Colitis	2.6	3.7	12.7	1.6	3.6	0.1	-1.3	-2.0	1.0
Diabetes (self-reported)	2.5	3.8	9.0	-3.0	-2.5	-1.1	-0.1	0.3	-2.5
Medication: Blood pressure	2.5	4.4	10.4	-2.1	-3.2	-1.1	0.8	2.1	-2.4
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	9.8	-0.3	-1.2	-2.4	-0.9	1.3	-3.1
High blood pressure (mother)	2.3	3.2	6.6	-2.0	-2.2	-1.5	-0.6	1.1	-2.6
Rheumatoid Arthritis	2.2	3.0	5.1	1.9	2.0	0.7	-1.0	-2.0	2.3
Hypothyroidism (self reported)	2.2	5.0	16.9	-0.6	-0.7	4.1	-1.6	-2.1	2.3
Migraine (self-reported)	2.2	2.8	5.4	1.6	1.9	1.4	-0.9	-1.5	2.3
Back pain experienced in last month	2.2	3.2	6.6	2.6	0.9	0.6	-1.5	-2.6	1.6
Type 2 Diabetes (T2D) (2018)	2.1	3.9	8.4	-2.4	-2.3	-1.6	0.1	1.1	-2.9
Waist Hip Ratio (WHR)	2.0	8.8	18.7	-3.6	-0.2	-4.3	0.1	2.3	-4.0
Diabetes (mother)	2.0	2.6	7.1	-1.4	-0.6	-2.1	0.8	1.0	-2.7
Happiness	2.0	2.5	3.8	1.2	1.5	1.9	1.9	1.0	1.8
Prospective memory result	2.0	2.4	6.9	0.7	-0.8	-0.9	-2.6	-2.4	-0.4
Blood Eosinophil Count	1.9	14.8	60.8	0.7	4.1	-7.8	-1.9	-1.7	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	5.1	2.1	1.8	0.4	2.3	1.0	1.2
Alcohol intake versus 10 years previously	1.9	2.9	7.4	2.6	1.3	0.8	0.4	-0.8	2.7
Birth weight of first child	1.9	3.4	6.9	2.6	1.9	1.9	1.2	-0.0	2.1
Diabetes diagnosed by doctor	1.9	3.1	6.9	-2.6	-2.6	-0.9	0.2	0.6	-2.0
Medication: Lisinopril	1.9	2.5	4.6	-1.4	-0.9	-1.2	1.4	2.0	-2.1
Ever smoked	1.9	3.4	9.1	2.5	3.0	-0.9	1.0	0.5	1.8
Pack years adult smoking proportion	1.8	2.7	11.0	1.4	0.4	-3.3	-0.4	0.3	-1.7
Hayfever, allergic rhinitis or eczema	1.8	4.0	10.4	-0.6	-1.7	-3.0	-0.6	1.0	-3.2
Ever taken oral contraceptive pill	1.8	2.0	4.8	-0.6	-1.1	-0.8	-2.2	-0.3	-2.2
Number of treatments/medications taken	1.7	3.1	9.4	-0.9	-3.1	-1.4	0.6	1.2	-2.2
Diabetes (father)	1.7	2.1	4.4	-2.1	-1.0	-1.7	-0.7	0.7	-1.9
Waist circumference	1.7	6.1	22.3	-1.2	-0.2	-4.7	-0.1	0.4	-3.6
Past tobacco smoking	1.7	3.1	6.4	-2.5	-2.4	0.5	-1.5	-0.6	-1.9
Heart attack	1.7	2.2	5.8	1.0	-1.2	1.4	2.4	1.5	0.8
Medication: Ramipril	1.7	2.1	7.9	-1.3	-2.8	-0.4	1.3	0.8	-1.0
Medication: Omeprazole	1.7	2.0	4.0	-2.0	0.2	-1.6	1.1	1.1	-1.8
Guilty feelings	1.7	2.6	6.0	1.4	1.1	1.1	2.2	0.7	2.4
Age started oral contraceptive pill	1.7	2.1	5.2	-0.3	-1.7	1.5	-1.5	-2.3	0.4
Blood Platelet Count	1.6	18.2	53.1	2.5	7.3	3.1	1.9	-3.0	5.2
Father’s age at death	1.6	2.2	5.7	0.2	1.3	1.9	-0.4	-1.3	2.4
Pulse wave Arterial Stiffness index	1.6	1.9	4.2	-0.2	1.6	-0.6	-1.5	-2.0	1.4
Hypothyroidism/myxoedema (self-reported)	1.6	3.0	11.5	-1.3	-0.9	3.4	-0.9	-1.1	1.5
Knee pain experienced in last month	1.6	2.5	4.6	-1.1	2.1	-1.9	-1.3	-2.1	-0.2
Hypertension (Self-reported)	1.6	4.5	8.5	-2.9	-2.7	-1.4	-1.0	0.8	-2.7
Commuting to job workplace: Walk	1.6	1.7	5.3	-1.3	-2.3	-0.7	0.3	1.3	-1.0
Verbal and Numeric Reasoning (VNR)	1.5	3.7	10.8	0.4	-1.3	0.7	3.3	2.9	-0.3
Prostate Cancer	1.5	2.1	6.5	1.7	0.6	-2.6	-1.4	-0.8	0.7
Systolic Blood Pressure	1.5	7.5	18.1	-1.5	-4.3	1.2	0.8	4.1	-2.3
Allergy or Eczema	1.5	4.0	13.6	0.1	-0.9	-3.7	-0.2	1.5	-2.7
Lung FEV1/FVC ratio	1.5	7.7	14.9	-1.5	-2.5	-3.4	1.8	2.8	-3.9
Chronotype (morning person)	1.5	3.4	5.3	2.3	2.2	1.4	-1.1	-1.4	2.3
High blood pressure	1.5	4.3	8.8	-3.0	-2.7	-1.2	-0.5	1.2	-2.6
Stomach or abdominal pain in last month	1.5	1.9	5.2	2.3	1.8	-1.4	-0.2	-0.7	0.5
Breastfed as a baby	1.5	1.8	4.1	2.0	1.3	0.6	-1.4	-1.5	0.8
Forced vital capacity (FVC), Best measure	1.5	5.6	10.4	1.3	1.3	3.1	-2.1	-3.2	2.4
Age at first live birth	1.5	2.6	5.5	-1.9	-2.3	-0.1	-0.3	1.7	-1.9
Pulse wave peak to peak time	1.5	1.7	3.5	0.1	-1.7	0.6	1.2	1.9	-1.4
Had major operations	1.5	1.8	3.0	1.6	0.1	1.7	1.5	0.9	1.4
Average weekly red wine intake	1.5	2.2	4.5	-0.5	-1.4	1.6	2.1	1.6	1.2
Number of self-reported non-cancer illnesses	1.5	2.6	7.2	-1.2	-2.7	-1.5	0.2	0.7	-2.0
Illnesses of father: High blood pressure	1.5	1.9	2.8	-1.5	-1.7	-1.5	0.3	1.5	-1.2
Pain experienced in last month	1.5	2.4	5.1	-2.2	-1.6	0.7	0.7	2.3	-1.0
Heart attack/myocardial infarction (self-reported)	1.5	2.0	4.4	1.4	-1.2	1.5	2.1	1.0	1.0
Intelligence (Savage-Jansen 2018)	1.4	4.3	12.1	-0.4	-1.1	2.1	3.5	2.6	1.1
Lung FVC	1.4	7.1	13.2	2.9	2.2	3.3	0.1	-2.3	3.6
Medication for hormone replacement therapy	1.4	1.5	4.6	0.0	-1.0	-2.2	-0.1	0.4	-1.8
Supplements: Zinc	1.4	1.5	4.7	-0.0	0.1	-0.2	-2.2	-2.0	0.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.1	1.7	2.0	-1.2	0.7	-0.5	-0.1
Age at last live birth	1.4	2.1	4.5	-1.4	-2.1	-0.1	-0.4	1.6	-1.8
Smoking status: Previous	1.4	2.1	6.3	2.5	1.6	-0.2	0.8	-0.2	1.9
Medication: Bendroflumethiazide	1.4	2.2	4.3	-2.1	-1.9	-0.5	0.4	1.2	-1.8
Myopia	1.4	2.0	3.5	-1.8	-1.4	-1.3	0.0	1.4	-1.9
Vascular/heart problems diagnosed by doctor	1.4	3.8	10.1	2.3	3.2	0.8	-0.2	-1.4	2.3
Noisy workplace	1.3	1.6	5.9	2.4	0.7	-0.1	-1.1	-1.1	0.9
Comparative height size at age 10	1.3	7.0	22.7	-0.7	0.6	-0.3	-4.1	-4.8	1.3
Medication: Blood pressure	1.3	2.4	6.4	-1.9	-2.5	-0.9	0.2	1.4	-1.4
Heart disease (siblings)	1.3	1.6	3.1	-1.0	-1.8	1.4	1.6	1.0	-0.5
Pack years of smoking	1.3	1.8	7.6	1.0	0.1	-2.8	-0.4	0.2	-1.5
Bipolar Disorder or Schizophrenia	1.2	2.9	7.7	-0.1	1.2	-2.4	-2.8	-1.2	-1.1
Major Depression (MDD)	1.2	1.5	4.1	-0.6	1.3	-2.0	0.5	1.3	-0.9
Breast Cancer	1.2	2.9	6.3	0.2	-0.5	2.5	2.2	2.2	1.0
Bipolar Disorder (2011)	1.2	1.2	5.0	-0.9	0.1	0.1	-2.2	-1.1	0.2
Schizophrenia (2014)	1.2	2.6	7.1	0.2	0.0	-2.1	-2.7	-1.8	-0.8
Current tobacco smoking	1.2	1.9	4.6	1.1	1.1	-2.1	1.2	1.4	-1.0
Had menopause	1.2	1.6	4.3	-0.9	-0.8	2.1	-0.2	-1.8	0.5
Had other major operations	1.2	1.4	3.4	1.9	1.2	-1.0	-0.9	-1.3	-0.2
Forced vital capacity (FVC)	1.2	4.7	10.6	0.5	0.7	3.2	-1.4	-2.7	2.7
Fluid intelligence score	1.2	2.5	6.7	-0.3	-0.8	0.9	2.5	2.6	-0.4
Worrier / anxious feelings	1.2	2.2	4.6	2.2	0.4	0.1	1.9	0.9	2.0
Number of children fathered	1.2	1.4	2.0	-1.3	-1.3	1.2	1.2	1.4	-0.0
Heart disease (mother)	1.2	1.4	3.6	-1.2	-1.9	0.7	-0.7	-0.4	-1.5
Number of full sisters	1.2	1.4	3.2	-1.0	-1.8	0.4	0.7	1.0	-1.6
Overall health rating	1.2	2.6	5.4	-1.8	-0.3	0.2	2.3	2.1	-1.6
Schizophrenia (2018)	1.1	2.3	5.2	0.6	1.0	-2.1	-2.3	-1.0	-1.3
Irritable Bowel Disease (IBD)	1.1	2.7	5.1	0.9	2.2	-0.7	-2.3	-2.2	-0.2
Body Mass Index (BMI) (2010)	1.1	1.4	3.3	-1.4	-1.3	-0.8	0.6	0.9	-1.8
Sensitivity / hurt feelings	1.1	1.8	5.0	0.2	-0.4	-1.1	2.2	2.2	0.2
Hearing difficulty/problems: Yes	1.1	1.7	3.4	-1.6	1.8	1.2	1.3	0.8	0.7
Supplements: Glucosamine	1.1	1.5	5.3	1.1	-1.5	-2.3	0.0	0.1	-0.5
Allergy	1.1	2.6	6.6	0.4	1.3	2.6	1.1	0.2	2.5
Illnesses of siblings	1.1	1.5	3.3	0.5	1.8	0.6	-1.3	-1.4	1.2
Exposure to tobacco smoke outside home	1.1	1.5	3.7	1.8	1.1	-1.9	0.8	0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.2	0.1	1.8	1.0	1.1	0.8	1.4
Number of operations (self-reported)	1.1	1.7	8.7	3.0	0.7	0.3	0.8	0.1	0.3
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.3	-2.1	-0.7	-0.2	-0.2	0.4	-1.3
Ever had hysterectomy (womb removed)	1.0	1.2	2.0	1.1	1.2	-0.5	-1.2	-1.4	-0.9
Angina	1.0	1.3	2.6	1.1	-1.6	1.4	1.0	1.0	0.0
Maternal smoking around birth	1.0	1.5	5.4	-1.5	0.2	-2.3	0.5	0.6	-0.6
Number of incorrect matches in round	1.0	1.6	4.8	-0.2	-0.7	-1.2	-1.6	-2.2	-0.6
Financial difficulties in last 2 years	1.0	1.4	3.0	1.7	-0.4	-0.4	1.7	1.4	0.4
Pulse rate	1.0	1.7	4.3	2.1	1.7	-0.6	-0.9	-1.4	0.2
Medication: Amlodipine	1.0	1.4	5.2	-1.7	-2.3	0.1	-0.4	-0.3	-0.5
Angina (self-reported)	1.0	1.3	3.3	0.9	-1.8	1.2	1.1	1.1	-0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	0.1	0.6	-0.6	1.6	1.7	-1.0
Alcohol drinker status: Never	1.0	1.2	2.2	-0.8	-0.1	-1.3	-1.5	-1.4	-0.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.6	0.3	1.9	0.3	0.8	0.2	1.6
Smoking Status	0.9	2.3	4.2	1.9	1.0	-2.0	1.9	1.2	-0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.6	0.0	0.3	0.2	-1.5	-2.1	0.3
Average weekly fortified wine intake	0.9	1.1	4.1	-0.4	0.1	-2.0	-0.1	0.7	-1.3
Age when periods started (menarche)	0.9	2.3	5.5	1.2	0.2	2.3	1.4	1.5	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	4.3	1.3	0.3	0.5	2.1	1.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.5	1.0	0.7	0.4	2.3	1.0	1.0
Pulse wave reflection index	0.9	1.2	5.5	-2.3	0.0	-1.0	-0.5	-0.1	0.3
Wheeze or whistling in the chest in last year	0.9	1.7	4.4	1.0	1.2	-2.1	1.2	1.1	-0.8
Supplements: Vitamin C	0.9	1.0	2.7	-0.5	-0.3	-1.1	-1.6	-1.3	-0.3
Smoking status: Current	0.9	1.5	2.6	0.9	0.8	-1.3	1.6	1.6	-0.8
Average weekly champagne plus white wine intake	0.9	1.2	4.2	-2.0	-0.9	1.1	-0.5	0.6	-0.5
Financial situation satisfaction	0.9	1.1	2.9	1.1	0.3	-0.1	1.6	1.7	0.0
Alcohol drinker status: Previous	0.9	1.1	2.8	1.2	1.7	-0.4	0.0	0.1	1.4
Age at First Birth	0.8	1.1	2.0	1.3	-1.4	0.3	0.4	1.1	1.2
BMI	0.8	4.5	18.7	1.2	0.8	-4.3	-0.7	-0.3	-2.4
Qualifications: CSEs or equivalent	0.8	1.1	3.8	-0.2	1.2	-2.0	0.3	0.6	-0.8
Medication: Atenolol	0.8	1.0	2.0	-1.1	-1.0	0.4	1.2	1.4	-0.5
Medication: Levothyroxine sodium	0.8	1.4	6.8	-0.2	-0.2	2.6	-0.2	-0.4	1.0
Mouth/teeth dental problems: Dentures	0.8	1.3	3.1	1.8	0.8	-1.6	1.0	0.7	-0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.0	1.3	-0.1	-0.8	-1.0	-1.7	0.2
Blood clot in the leg (DVT)	0.8	1.1	2.3	0.7	1.3	0.2	-1.2	-1.5	0.9
Gout (self-reported)	0.8	1.1	3.1	-0.9	-1.8	0.1	1.2	0.8	-1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.9	-1.2	1.1	-1.4	-0.5	-0.7	-0.1
Leg fat percentage (right)	0.8	3.1	9.2	0.5	1.3	-3.0	1.8	1.2	-1.6
Leg pain on walking	0.8	1.0	2.6	1.2	-0.8	1.0	1.6	0.2	0.4
Qualifications: nursing, teaching	0.8	1.2	2.8	-1.7	-0.6	-0.7	-1.1	-0.0	-1.5
Leg fat percentage (left)	0.8	3.0	9.4	0.3	1.0	-3.1	1.8	1.3	-1.6
Irritability	0.8	1.4	2.5	1.6	1.4	-0.5	1.2	1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	0.4	1.0	0.4	-1.1	-1.5	0.9
Neuroticism (2016)	0.7	1.0	4.6	-0.5	-0.2	-2.2	-0.3	-1.0	-0.3
Blood White Count	0.7	4.9	15.8	0.9	4.0	-3.1	1.5	0.9	-0.0
Frequency of depressed mood in last 2 weeks	0.7	0.9	3.9	0.7	2.0	-0.4	0.7	-0.1	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.0	-0.1	0.5	0.7	-1.2	-1.7	-0.3
Leg fat-free mass (left)	0.7	3.6	7.2	-0.1	0.1	-2.4	-2.7	-2.7	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.3	0.1	1.1	0.8	0.8	-0.1	1.5
Leg predicted mass (left)	0.7	3.7	7.5	-0.1	0.1	-2.4	-2.7	-2.7	-1.1
Hearing difficulty/problems with background noise	0.7	1.2	2.5	-1.4	0.8	-0.0	1.6	1.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.9	0.2	-1.4	-0.8	1.0	1.3	-0.6
Neuroticism score	0.7	1.6	4.1	1.3	0.8	-0.5	2.0	1.0	1.3
Number of live births	0.7	1.0	3.2	-0.9	-0.1	0.8	1.8	1.2	-0.2
Asthma	0.7	1.4	4.5	-0.3	0.1	-2.1	0.0	-0.2	-2.0
Impedance of arm (left)	0.7	3.2	7.8	0.6	0.6	1.4	-2.7	-2.8	0.9
Hair/balding pattern: Pattern 4	0.7	1.6	2.8	0.3	-0.2	1.5	1.6	1.3	1.7
Glaucoma (self-reported)	0.7	0.8	3.0	-0.1	-0.6	-0.3	1.7	0.9	-0.9
Birth weight	0.7	1.5	4.2	-0.4	-2.1	2.0	0.2	-0.2	0.3
Shortness of breath walking on level ground	0.7	0.8	1.4	0.5	-1.2	-0.7	0.9	0.9	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	5.8	-0.5	-0.0	2.4	0.2	-0.0	1.0
Pulse rate, automated reading	0.7	2.4	8.0	-0.1	-1.2	-1.8	-1.3	-0.1	-2.8
Chest pain or discomfort	0.7	1.0	2.8	1.7	1.6	-0.3	0.7	-0.2	-0.2
Leg fat-free mass (right)	0.7	3.6	7.4	-0.3	-0.3	-2.4	-2.7	-2.6	-1.1
Arm fat percentage (left)	0.7	2.8	8.6	0.5	1.0	-2.9	-1.3	-1.7	-1.5
Loneliness, isolation	0.7	0.9	3.2	1.8	0.8	-0.3	0.9	-0.3	0.8
Leg predicted mass (right)	0.7	3.5	7.3	-0.3	-0.2	-2.4	-2.7	-2.6	-1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.6	0.8	1.6	0.4	-0.6	-0.5	0.9
Average weekly beer plus cider intake	0.7	1.0	2.5	1.6	0.5	-1.6	0.1	-0.1	0.6
Unable to work because of sickness or disability	0.7	1.0	2.4	1.1	1.6	-0.7	-0.0	-1.1	0.7
Supplements: Calcium	0.7	0.8	2.8	-1.0	-1.7	0.9	0.1	-0.3	-0.2
Bipolar Disorder (2018)	0.6	0.9	2.5	-0.7	0.6	-1.2	-1.6	-0.7	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	-0.5	-1.0	-0.5	1.0	1.1	-0.9
Alzheimer’s Disease (in father)	0.6	0.6	1.7	-0.4	0.5	-0.7	-1.3	-0.8	-0.6
Fasting Glucose	0.6	0.8	1.9	-0.8	-1.3	0.2	-0.4	-0.2	-1.4
Heel T-Score	0.6	4.5	9.5	-2.5	-3.1	-2.3	-0.6	0.6	-2.4
Height	0.6	10.8	37.8	-1.0	-1.6	0.2	-6.2	-4.8	-0.2
Neuroticism	0.6	1.5	3.9	0.9	1.3	-0.8	2.0	1.2	0.6
Relative age of first facial hair	0.6	1.2	2.2	1.4	0.4	0.7	1.3	0.6	1.5
Trunk fat percentage	0.6	2.3	7.0	0.7	1.4	-2.6	-1.1	-1.5	-1.0
Fed-up feelings	0.6	1.1	3.7	0.2	-0.6	-0.6	1.6	1.9	0.3
Body mass index (BMI)	0.6	2.6	12.2	0.3	0.7	-3.5	0.3	-0.0	-1.7
Trunk fat mass	0.6	2.6	8.4	0.5	0.8	-2.9	-1.5	-1.7	-1.2
Alcohol usually taken with meals	0.6	1.0	3.0	-1.7	0.2	1.1	-1.2	-0.5	0.3
Hair/balding pattern: Pattern 2	0.6	0.7	2.3	0.5	-1.2	0.1	-0.6	0.1	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	5.5	0.1	-2.3	-1.0	0.9	0.9	-0.3
Qualifications: None of the above	0.6	1.3	2.9	1.1	1.7	-1.7	0.7	-0.1	0.3
Mouth/teeth dental problems	0.6	0.9	2.5	-1.6	0.2	1.5	0.2	0.7	0.4
Weight	0.6	3.0	9.7	-0.3	0.0	-3.1	-1.7	-1.6	-1.6
Arm fat percentage (right)	0.6	2.5	9.2	0.6	1.2	-3.0	-0.9	-1.2	-1.4
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.7	-1.6	-1.2	1.1	0.5	1.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.9	1.4	0.9	-0.1	0.5	0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.5	0.5	0.6	1.8	-1.4	-1.9	1.2
Arm fat mass (right)	0.6	2.6	9.9	-0.1	0.7	-3.1	-1.1	-1.2	-1.6
Standing height	0.6	6.2	18.9	-1.4	-1.6	0.7	-4.3	-3.6	0.3
Loud music exposure frequency	0.6	0.7	2.2	1.0	0.2	0.8	1.5	0.3	-0.4
High blood pressure (siblings)	0.6	0.9	2.1	-0.7	-1.0	-1.1	0.3	0.8	-1.5
Emphysema/chronic bronchitis	0.6	0.6	1.2	1.1	0.3	0.8	0.9	0.8	0.6
Neck or shoulder pain in last month	0.6	0.9	1.9	0.4	-0.0	-1.4	-1.3	-0.6	-1.2
Whole body fat mass	0.6	2.6	9.7	0.0	0.6	-3.1	-1.2	-1.3	-1.5
Leg fat mass (right)	0.6	2.4	10.6	0.4	1.1	-3.3	0.2	-0.3	-1.6
Family relationship satisfaction	0.6	0.8	2.0	0.7	1.4	0.6	0.6	0.2	1.1
Medication: Aspirin	0.6	0.8	1.9	0.8	-1.1	-0.3	1.4	1.1	-0.1
Illnesses of siblings: Diabetes	0.6	0.7	3.3	-0.2	-1.8	-0.4	0.7	0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.2	1.5	-0.0	1.3	0.4	0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.3	-1.1	-0.4	-1.0	0.7	0.7	-0.6
Breast cancer (self-reported)	0.6	0.7	2.7	0.5	0.3	0.6	-0.6	-1.6	0.3
Osteoarthritis (self-reported)	0.6	0.8	2.6	1.0	0.6	0.2	1.6	1.0	0.1
Arm fat mass (left)	0.6	2.6	9.7	-0.2	0.4	-3.1	-1.1	-1.2	-1.7
Wears glasses or contact lenses	0.6	0.7	3.5	-1.9	-0.2	0.1	-0.5	-0.4	-0.4
Mother’s age at death	0.6	0.7	2.1	-1.5	0.2	0.8	-1.0	-0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.2	-0.2	1.5	-0.3	0.5	-1.3	0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.7	-1.3	-0.4	-0.6	-0.9	-1.1	-0.4
Fractured/broken bones in last 5 years	0.6	0.8	2.0	-0.9	-0.4	-0.3	1.4	1.2	-0.5
Leg fat mass (left)	0.6	2.4	11.0	0.2	1.0	-3.3	0.2	-0.1	-1.5
Depression (Nagel 2018)	0.5	0.8	1.6	0.2	1.1	1.3	1.0	-0.1	1.1
Reaction Time	0.5	0.9	1.9	1.4	1.1	-1.0	-0.7	-0.9	0.4
Lupus	0.5	0.8	2.0	-0.2	0.6	1.4	0.7	0.8	1.0
Average weekly spirits intake	0.5	0.6	1.2	-0.2	-1.1	-1.0	-0.5	-0.6	-0.9
Systolic blood pressure, automated reading	0.5	1.5	4.5	-0.9	-2.1	1.3	0.1	1.2	-0.7
Severe depression (siblings)	0.5	0.5	2.0	1.4	-0.1	0.0	-0.3	-1.0	0.1
Serious illness, injury or assault to yourself	0.5	0.7	1.7	1.3	0.7	0.4	0.8	0.5	0.8
Sitting height	0.5	3.3	9.1	-2.0	-1.2	0.8	-3.0	-2.1	-0.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.6	1.0	0.3	-0.4	-1.5	0.3
Impedance of arm (right)	0.5	2.2	5.8	0.4	0.9	0.8	-2.4	-2.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.7	0.0	0.0	1.9	-0.9	-1.6	1.6
Lung cancer (father)	0.5	0.6	1.1	-0.9	-1.0	-0.5	-0.2	0.7	-1.1
Length of working week for main job	0.5	0.6	1.9	0.2	1.4	-0.9	0.4	0.7	-0.1
Tense / ‘highly strung’	0.5	0.8	1.9	1.4	0.5	-1.2	0.5	0.3	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-0.9	-0.4	0.9	0.8	0.9	-0.3
Medication: Paracetamol	0.5	0.9	2.2	-0.2	0.2	-0.8	-1.5	-1.4	-0.7
Body fat percentage	0.5	2.1	8.0	0.6	1.4	-2.8	-0.4	-0.9	-1.2
Worry too long after embarrassment	0.5	0.8	2.1	0.5	0.8	0.3	1.1	-0.5	1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.1	1.8	0.6	0.0	0.1	-0.2	-0.1
Suffer from ‘nerves’	0.5	0.7	2.4	-0.1	1.5	-1.3	-0.3	-0.0	0.2
Long-standing illness, disability or infirmity	0.5	0.7	2.3	0.3	-0.7	0.3	1.5	1.1	-0.5
Friendships satisfaction	0.5	0.7	1.7	0.7	0.3	0.6	1.3	1.2	-0.1
Asthma (self-reported)	0.5	1.1	3.2	-0.2	-0.1	-1.8	0.3	0.1	-1.7
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-0.5	1.1	0.6	-1.2	-0.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.2	0.3	0.3	2.0	0.5	-0.3	1.4
Basal metabolic rate	0.5	2.6	5.7	-0.5	-0.4	-2.4	-2.1	-1.9	-1.2
Risk taking	0.5	0.7	1.8	1.0	1.3	-0.3	0.1	-0.3	1.1
Ever depressed for a whole week	0.5	0.7	2.0	-0.3	0.0	-0.4	1.4	1.2	0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	-0.7	-0.5	0.9	-1.2	-0.1	-0.7
Worry (Nagel 2018)	0.4	0.8	1.4	1.2	0.9	-0.4	0.9	0.6	1.1
Crohns Disease (2012)	0.4	0.6	1.7	0.1	-0.7	0.7	1.3	0.8	-0.7
Mean Putamen Volume	0.4	0.5	1.2	-0.8	0.3	-0.2	-0.8	-1.1	-0.5
Respiratory disease	0.4	0.9	3.5	0.4	1.0	-1.9	0.6	-0.5	-0.1
Hand grip strength (left)	0.4	0.9	2.7	1.6	0.3	0.7	0.8	1.2	0.5
Hip circumference	0.4	1.9	6.2	-0.0	0.1	-2.5	-1.1	-1.4	-1.4
Trunk predicted mass	0.4	2.1	4.0	-1.3	-1.1	-1.5	-2.0	-1.5	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	0.9	0.6	0.0	0.0	-1.0	1.2
Peak expiratory flow (PEF)	0.4	0.8	2.5	0.1	-0.7	0.1	1.5	1.6	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	0.1	-0.3	1.4	-0.8	-0.5	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	0.8	0.2	-0.3	1.0	-0.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	-0.8	0.2	0.6	-0.9	-0.9	0.3
Health satisfaction	0.4	0.5	1.3	-0.7	0.5	-0.2	-0.8	-0.5	-1.1
Medication: Ibuprofen	0.4	0.5	1.4	0.7	1.2	0.5	0.6	0.3	0.7
Medication: Allopurinol	0.4	0.5	2.2	0.3	-0.8	0.2	1.5	0.3	0.4
Mean time to correctly identify matches	0.4	0.7	2.2	0.4	0.6	-0.9	-1.0	-1.5	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.4	-0.5	0.3	0.1	1.2	0.6	0.6
Whole body fat-free mass	0.4	2.3	4.6	-0.7	-0.5	-1.9	-2.1	-1.9	-1.0
Mood swings	0.4	0.8	3.6	0.9	0.0	-1.9	0.1	0.5	-0.1
Medication: Aspirin	0.4	0.5	1.4	0.7	-1.2	-0.1	1.0	0.7	0.1
Whole body water mass	0.4	2.3	4.5	-0.7	-0.5	-2.0	-2.1	-1.9	-1.0
Commuting to job workplace: Public transport	0.4	0.4	1.4	-0.0	-0.6	-0.3	-1.2	-0.8	-0.0
Diastolic blood pressure, automated reading	0.4	1.2	3.0	-1.7	-1.5	-0.6	-1.0	-0.3	-0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.8	0.7	0.6	-0.7	1.3	0.9	0.5
HbA1C	0.3	0.3	0.7	-0.3	-0.7	-0.5	-0.3	0.6	-0.9
Primary Biliary Cirrhosis	0.3	0.5	1.2	0.3	0.8	1.1	0.6	-0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.0	0.5	-0.8	-0.2	0.5	-0.9
Impedance of leg (right)	0.3	1.6	3.7	0.4	0.8	1.3	1.7	1.9	0.6
Hand grip strength (right)	0.3	0.7	1.4	1.0	-0.3	1.2	0.4	0.6	1.1
Townsend deprivation index at recruitment	0.3	0.4	1.4	0.4	-0.3	-0.2	1.2	0.8	-0.1
Taking other prescription medications	0.3	0.4	1.6	0.5	-0.5	0.0	1.3	0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	0.8	-1.4	-0.8	-0.3	-0.8	0.4
Impedance of leg (left)	0.3	1.5	4.5	-0.0	0.3	1.2	1.7	2.1	0.5
Trunk fat-free mass	0.3	2.0	3.7	-1.2	-1.1	-1.5	-1.9	-1.4	-1.0
Falls in the last year	0.3	0.4	1.2	1.1	0.6	-0.3	0.8	-0.2	0.4
Depression (self-reported)	0.3	0.3	1.8	-1.3	0.3	-0.3	0.1	-0.3	0.2
Headache pain in last month	0.3	0.6	0.9	0.1	0.9	-0.8	-0.9	-0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.4	-1.2	-0.2	0.2	0.2	-0.8
Qualifications: College or University degree	0.3	0.9	2.5	-0.3	-1.3	1.6	0.6	0.9	0.3
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.7	-0.7	-0.7	-0.6	-0.2	-0.8
Alcohol intake frequency.	0.3	0.7	2.5	-0.4	0.7	0.0	-0.6	-1.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.6	1.3	0.1	-0.6	0.4	0.2	-0.3
Eye problems/disorders: Cataract	0.3	0.4	0.6	0.7	-0.8	0.3	0.5	-0.4	-0.7
Osteoporosis (self-reported)	0.3	0.3	1.4	-0.4	-1.2	0.5	-0.3	-0.0	-0.2
Medication: Paracetamol	0.3	0.5	0.6	-0.6	0.8	-0.1	-0.8	-0.7	-0.8
Depressed Affect (Nagel 2018)	0.2	0.3	1.2	-0.0	-0.0	-0.4	1.1	0.7	-0.1
Blood Red Count	0.2	1.5	3.5	0.5	1.9	0.7	1.7	-0.6	1.3
Hair Pigment	0.2	6.7	17.2	-2.4	-2.5	-2.8	-1.1	1.3	-4.2
Vitamin and mineral supplements	0.2	0.2	0.5	0.7	0.1	0.5	0.4	0.4	0.6
Medication: Co-codamol	0.2	0.2	0.4	0.2	0.5	0.1	0.5	-0.7	0.3
Relative age voice broke	0.2	0.2	0.8	-0.2	-0.9	0.5	0.2	0.5	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.5	-0.7	0.6	0.4	-0.2	-0.3
Multivitamins +/- minerals	0.2	0.3	0.8	-0.1	0.3	-0.2	0.8	0.9	0.1
Exposure to tobacco smoke at home	0.2	0.2	0.8	0.0	0.3	-0.2	0.5	0.5	-0.9
Arm fat-free mass (right)	0.2	1.0	3.4	-0.3	-0.5	-1.8	-1.0	-0.9	-0.7
Comparative body size at age 10	0.2	0.4	0.9	0.5	-1.0	-0.9	0.1	0.4	-0.5
Number of full brothers	0.2	0.2	0.7	-0.0	-0.0	0.5	0.8	0.6	0.3
Eye problems/disorders: None of the above	0.2	0.3	1.1	-0.1	-0.3	0.1	0.2	1.0	0.6
Arm predicted mass (right)	0.2	1.2	3.3	-0.5	-0.6	-1.8	-1.2	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.7	-1.1	0.1	0.3	-1.3	-0.0	-0.1
Ever had bowel cancer screening	0.2	0.2	0.5	-0.6	0.7	-0.5	0.2	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.4	1.2	0.1	-0.0	0.1	-0.5	0.3
Miserableness	0.2	0.3	0.6	0.4	-0.5	-0.4	0.8	0.6	-0.5
Hearing aid user	0.2	0.2	0.5	-0.5	0.7	-0.4	-0.3	0.4	-0.2
Eye problems/disorders: Glaucoma	0.2	0.3	1.3	0.6	0.1	-0.3	1.2	-0.0	-0.2
Arm fat-free mass (left)	0.2	0.9	3.4	-0.5	-0.4	-1.9	-0.7	-0.5	-0.8
Impedance of whole body	0.2	0.8	2.4	0.4	0.6	1.6	-0.9	-0.7	0.8
Arm predicted mass (left)	0.2	0.8	3.3	-0.5	-0.1	-1.8	-0.5	-0.6	-0.7
Tanning	0.1	1.5	4.9	-0.4	1.0	-0.9	-2.2	-1.4	-0.4
Nervous feelings	0.1	0.2	0.6	-0.4	0.6	0.2	0.8	0.5	0.0
Pain all over the body in last month	0.1	0.1	0.4	0.4	0.1	-0.1	0.6	-0.1	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.7	-0.0	-0.6	0.0	0.2	-0.2
Mineral and other dietary supplements	0.1	0.2	0.7	0.2	0.1	0.4	0.5	0.8	-0.1
Crohns Disease (2017)	0.0	0.1	0.4	0.1	0.3	-0.0	0.2	0.3	-0.6

Hub : Genes

PAFAH1B2

Models

Trait associations