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chr17:37,083,464-39,048,774

Best TWAS P=1.67e-14 · Best GWAS P=3.08e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ORMDL3	0.09	0.08	enet	10	0.06	4.2e-08	7.21	6.0	1.7e-09	0.87	0.06	0.94	FALSE
2	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	-7.02	-6.5	6.7e-11	-0.80	0.05	0.62	FALSE
3	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	-4.81	-5.8	6.3e-09	-0.75	0.02	0.96	FALSE
4	GTEx	Cells Transformed fibroblasts	ORMDL3	0.24	0.09	enet	21	0.07	7.8e-06	7.21	5.8	5.7e-09	0.82	0.08	0.92	FALSE
5	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	-7.50	7.3	3.0e-13	0.92	0.02	0.98	FALSE
6	GTEx	Colon Transverse	PGAP3	0.24	0.20	enet	19	0.20	8.3e-10	4.63	5.4	6.6e-08	0.55	0.99	0.01	FALSE
7	GTEx	Esophagus Mucosa	GSDMB	0.06	0.04	lasso	3	0.03	4.7e-03	5.66	6.5	1.2e-10	0.76	0.05	0.80	FALSE
8	GTEx	Esophagus Mucosa	ORMDL3	0.09	0.01	enet	20	0.00	1.8e-01	4.45	5.9	3.7e-09	0.63	0.06	0.48	FALSE
9	GTEx	Esophagus Muscularis	PGAP3	0.11	0.08	enet	10	0.10	1.1e-06	4.63	5.5	3.6e-08	0.65	0.66	0.32	FALSE
10	GTEx	Heart Atrial Appendage	PPP1R1B	0.09	0.04	enet	10	0.08	2.2e-04	5.96	6.9	7.0e-12	0.82	0.08	0.85	FALSE
11	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	-7.02	6.5	6.6e-11	0.82	0.10	0.55	FALSE
12	GTEx	Liver	PGAP3	0.27	0.17	lasso	4	0.13	1.7e-04	4.95	5.5	3.7e-08	0.64	0.48	0.34	FALSE
13	GTEx	Lung	GSDMB	0.07	0.07	lasso	4	0.05	1.5e-04	7.21	7.3	2.4e-13	0.93	0.04	0.93	FALSE
14	GTEx	Lung	ORMDL3	0.16	0.13	enet	15	0.14	1.6e-10	7.30	6.9	6.0e-12	0.92	0.04	0.96	FALSE
15	GTEx	Muscle Skeletal	PGAP3	0.04	0.03	lasso	5	0.04	1.3e-04	4.65	5.3	1.1e-07	0.55	0.63	0.07	FALSE
16	GTEx	Pancreas	PGAP3	0.37	0.25	lasso	6	0.21	1.9e-09	4.95	5.9	3.4e-09	0.67	0.90	0.10	FALSE
17	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	4.64	5.3	1.0e-07	0.56	0.18	0.25	FALSE
18	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	4.96	6.6	4.9e-11	0.78	0.11	0.73	FALSE
19	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	7.20	7.0	1.8e-12	0.93	0.07	0.93	FALSE
20	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	7.20	7.3	2.7e-13	0.95	0.07	0.93	FALSE
21	GTEx	Thyroid	PGAP3	0.19	0.21	lasso	10	0.24	3.5e-18	4.98	5.7	1.4e-08	0.68	1.00	0.00	FALSE
22	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	7.30	7.5	9.0e-14	0.98	0.04	0.96	FALSE
23	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	7.21	7.3	3.0e-13	0.93	0.05	0.95	FALSE
24	METSIM	Adipose	GSDMA	0.14	0.16	lasso	7	0.17	2.6e-24	5.66	-5.4	8.3e-08	-0.62	1.00	0.00	FALSE
25	METSIM	Adipose	RP11-387H17.4	0.04	0.00	bslmm	286	0.01	8.4e-03	0.67	-5.8	8.0e-09	-0.71	0.03	0.67	FALSE
26	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	6.92	7.0	3.7e-12	0.91	0.06	0.94	FALSE
27	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	-7.05	-6.7	1.7e-11	-0.85	0.04	0.96	FALSE
28	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	-7.22	6.8	8.0e-12	0.89	0.02	0.98	FALSE
29	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	7.31	7.1	1.5e-12	0.93	0.04	0.96	FALSE
30	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	7.31	6.8	7.7e-12	0.90	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	-7.23	7.5	8.1e-14	0.93	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	-7.23	7.2	5.2e-13	0.93	0.02	0.61	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMB	0.06	0.05	enet	7	0.05	2.2e-06	7.49	7.3	3.7e-13	0.99	0.01	0.98	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	7.45	7.2	4.1e-13	0.97	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	7.45	7.6	3.5e-14	0.96	0.01	0.90	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	-7.50	7.7	1.7e-14	0.97	0.01	0.99	TRUE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	-7.22	7.2	5.6e-13	0.91	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	-6.62	7.3	2.6e-13	0.94	0.02	0.90	FALSE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	PGAP3	0.20	0.14	blup	38	0.16	1.4e-04	4.63	5.3	1.4e-07	0.65	0.02	0.63	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	7.27	7.6	4.0e-14	0.96	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	IKZF3	0.03	0.01	blup	43	0.02	1.3e-02	7.31	-6.0	1.4e-09	-0.85	0.01	0.67	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZPBP2	0.08	0.09	enet	5	0.10	6.1e-08	7.59	-7.4	1.0e-13	-0.99	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	7.49	7.1	1.0e-12	0.92	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	7.21	7.3	3.1e-13	0.96	0.02	0.98	FALSE