Hub : Genes

PPM1K

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.2530	0.1000	4.3e-03	0.009	NA	-0.006	NA	-0.004	1.5e-01	NA	6.1e-01	NA	4.8e-01
2	NTR	Blood	0.0222	0.0097	3.1e-03	-0.001	0.004	-0.001	0.003	-0.001	7.8e-01	1.8e-02	6.4e-01	0.037	9.3e-01
3	TCGA	Breast Invasive Carcinoma	0.0368	0.0142	1.7e-06	0.048	0.024	0.039	NA	0.042	4.1e-10	8.7e-06	1.4e-08	NA	5.4e-09
4	TCGA	Liver Hepatocellular Carcinoma	0.0750	0.0380	1.3e-03	0.026	0.048	0.041	NA	0.037	2.2e-02	2.8e-03	5.2e-03	NA	7.8e-03
5	TCGA	Prostate Adenocarcinoma	0.1298	0.0378	3.2e-11	0.110	0.101	0.143	NA	0.103	1.5e-11	1.2e-10	8.8e-15	NA	7.4e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.2	5.2	-0.2	2.3	0.8	0.1	0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	-1.1	0.3	-0.8	-0.7	-0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.5	-0.3	0.2	0.8	-0.1
Depression (Nagel 2018)	1.5	2.3	5.3	-0.1	0.4	-2.2	-1.1	-2.3
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	-0.7	-0.6	-1.1	-0.5	-0.0
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.9	0.5	-0.1	-0.1	-0.6
Schizophrenia (2018)	0.9	1.9	2.9	-1.2	-1.4	-1.7	-1.0	-1.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.4	-0.8	-0.6	0.3	-0.6
Worry (Nagel 2018)	0.4	0.9	3.0	1.0	1.7	0.4	0.0	0.3
Alzheimer’s Disease (in mother)	0.8	1.0	2.1	1.3	-0.1	-0.4	-1.4	-1.0
Alzheimer’s Disease (in father)	1.1	1.2	3.3	1.8	0.4	0.5	1.1	1.0
Alzheimer’s Disease (including proxy)	0.6	0.8	3.9	2.0	-0.2	0.3	-0.3	0.0
Crohns Disease (2017)	0.2	0.5	1.6	-1.3	-0.5	-0.1	0.5	-0.5
Irritable Bowel Disease (IBD)	0.4	1.0	3.2	-1.8	-0.5	0.5	0.9	0.5
Ulcerative Colitis (UC)	0.6	1.1	2.0	-1.4	-0.8	0.6	1.0	1.1
Major Depression (MDD)	0.3	0.4	0.8	-0.2	0.7	-0.5	0.9	-0.6
Reaction Time	1.1	2.2	5.3	0.8	-0.4	-2.3	-1.0	-1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.5	-1.6	0.1	-0.7	-0.1	0.2
Breast Cancer	8.6	20.7	36.8	0.1	-4.2	-6.0	-3.7	-6.1
Ovarian Cancer	1.4	1.8	3.3	-0.3	-0.7	-1.8	-1.5	-1.7
Prostate Cancer	2.3	3.2	5.5	-1.2	2.0	2.3	0.9	2.1
Age at First Birth	0.8	1.1	2.1	-0.7	0.7	-1.0	-1.5	-1.2
Bipolar Disorder (2011)	1.0	0.9	4.0	-2.0	0.8	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	5.4	7.4	12.5	-2.3	2.5	2.3	3.5	2.9
Coronary Artery Disease (CAD)	0.6	0.7	1.5	0.2	0.3	-1.0	-1.2	-0.9
Crohns Disease (2012)	0.4	0.7	2.5	0.2	0.4	0.8	1.6	0.1
Mean Putamen Volume	1.0	1.1	2.2	1.3	-0.4	1.5	0.6	1.0
Fasting Glucose	1.3	1.5	3.7	-0.7	-1.1	-1.4	-0.4	-1.9
HbA1C	1.1	1.2	2.1	1.4	-0.4	1.5	0.7	1.2
HDL Cholesterol	0.7	1.2	2.9	1.7	-0.5	-0.2	-1.6	-0.5
LDL Cholesterol	0.5	0.7	2.4	0.1	-1.6	0.8	-0.5	0.5
Lupus	1.0	1.5	3.9	-1.6	2.0	0.2	0.9	0.2
Neuroticism (2016)	1.7	2.5	4.6	-0.0	0.9	2.1	1.8	1.9
Primary Biliary Cirrhosis	1.2	1.7	4.6	2.2	0.2	1.2	1.1	1.1
Rheumatoid Arthritis	0.8	1.2	4.2	0.1	-0.2	0.7	2.1	1.0
Schizophrenia (2014)	0.4	0.9	1.7	-0.9	-0.7	-1.2	-0.4	-1.3
Triglycerides	0.8	1.4	3.1	-1.8	-0.4	0.9	0.8	1.4
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.3	-0.3	-0.8	2.3	1.9	1.4
Ulcerative Colitis	0.3	0.5	0.9	-0.6	0.8	0.7	0.2	0.9
Blood Eosinophil Count	0.7	5.4	20.6	-4.5	-1.0	1.3	-0.7	1.7
Blood Platelet Count	0.1	1.2	3.3	-0.2	-0.0	1.2	1.0	1.8
Blood Red Count	0.1	1.0	3.2	-1.8	0.1	-0.5	-0.6	-1.1
Blood White Count	0.7	5.0	12.7	-1.3	1.5	1.9	3.6	2.2
Heel T-Score	3.8	30.0	91.0	9.5	-7.5	0.7	-1.5	0.6
BMI	2.8	16.3	29.2	-4.4	4.2	2.6	5.4	2.9
Height	0.3	5.1	19.4	4.4	-1.7	-0.4	-1.6	-0.1
Waist Hip Ratio (WHR)	0.3	1.3	2.9	-0.3	1.7	0.5	1.6	0.8
Systolic Blood Pressure	0.4	2.2	7.2	-0.3	-0.5	1.1	2.7	1.4
Smoking Status	0.3	0.8	1.6	0.9	-1.3	-0.4	-1.0	-0.6
Allergy or Eczema	0.1	0.3	0.6	-0.8	0.7	-0.0	-0.5	0.5
Cardiovascular Disease	0.6	2.0	7.2	-0.0	-0.2	0.6	2.7	1.5
Hypothyroidism (self reported)	1.3	2.9	10.3	-1.9	3.2	0.2	0.7	0.4
Respiratory disease	0.5	1.0	2.5	0.5	1.0	1.1	-0.1	1.6
Type 2 Diabetes (T2D) (2018)	1.6	3.0	7.3	-1.7	0.4	1.4	2.7	1.7
Lung FEV1/FVC ratio	0.3	1.8	3.6	1.4	-0.0	1.2	1.9	1.3
Lung FVC	0.4	2.0	6.9	1.4	-2.6	-0.3	-0.8	-0.8
Neuroticism	0.2	0.5	1.1	-0.4	0.8	0.5	1.1	0.6
Chronotype (morning person)	0.2	0.5	1.3	1.1	0.1	-0.1	0.4	-1.1
Hair Pigment	0.1	4.1	10.2	0.7	2.3	1.2	3.2	1.8
Tanning	0.1	1.2	2.6	1.6	1.3	-0.4	-1.4	-0.1
Hand grip strength (left)	0.3	0.8	1.9	-1.4	-0.0	-1.2	-0.1	-0.8
Number of treatments/medications taken	0.4	0.8	3.5	-0.0	0.5	0.1	1.9	0.2
Average weekly spirits intake	0.2	0.2	0.9	-0.3	0.3	0.4	-0.1	0.9
Sensitivity / hurt feelings	0.4	0.6	2.2	-0.1	-1.5	-0.3	-0.8	-0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	0.6	-0.4	-0.5	-1.2	-0.9
Hearing difficulty/problems: Yes	4.4	6.7	12.2	-1.9	3.2	1.8	3.5	1.9
Relative age of first facial hair	1.5	3.1	5.0	0.6	-1.3	-2.2	-1.9	-2.2
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.0	-1.3	1.3	1.4	1.1	1.1
Ever used hormone-replacement therapy (HRT)	2.0	2.5	6.6	-2.6	2.0	0.6	-0.0	1.3
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.9	0.8	-0.4	0.2	-0.1
Systolic blood pressure, automated reading	1.1	3.3	8.6	-1.5	1.8	0.8	2.9	1.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.2	-0.5	0.9	0.6	1.1	0.1
Angina	1.1	1.4	2.7	0.1	0.7	1.2	1.7	1.5
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.0	0.5	-0.2	-0.9	0.5
Vitamin and mineral supplements	1.1	1.4	4.4	0.3	-0.8	-1.0	-2.1	-1.0
Supplements: Zinc	0.2	0.3	0.7	-0.0	0.6	-0.4	-0.9	-0.3
Medication: Co-codamol	0.1	0.1	0.6	0.8	-0.1	-0.3	0.2	0.1
Medication: Metformin	1.0	1.4	3.8	-1.9	-1.0	0.1	1.4	-0.2
Diabetes (father)	1.0	1.2	3.4	-1.9	0.8	0.8	1.1	0.6
Diabetes (mother)	3.2	4.1	7.3	0.4	-0.7	-2.4	-2.7	-2.5
Severe depression (siblings)	1.0	1.2	2.2	1.1	-0.5	-1.5	-1.0	-1.0
Pack years adult smoking proportion	0.3	0.5	1.2	-0.0	0.9	0.1	1.1	0.7
Impedance of leg (right)	1.6	7.9	19.4	3.3	-4.4	-1.8	-1.8	-1.7
Leg fat-free mass (left)	0.9	4.9	7.8	-2.0	2.8	1.9	2.4	1.8
Trunk fat percentage	0.9	3.5	11.3	-1.8	1.2	0.9	3.4	0.7
Hand grip strength (right)	0.2	0.7	1.6	-1.2	-0.0	-1.1	-0.5	-0.5
Townsend deprivation index at recruitment	4.1	5.8	9.6	2.1	-2.4	-3.1	-1.3	-2.8
Current tobacco smoking	0.1	0.1	0.2	0.3	-0.4	-0.2	0.5	-0.0
Average weekly fortified wine intake	0.4	0.4	1.2	1.1	-0.6	0.7	0.1	-0.1
Maternal smoking around birth	1.7	2.5	6.2	-2.5	1.9	0.9	1.0	0.8
Fed-up feelings	0.1	0.2	0.4	0.1	-0.3	0.5	0.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	-0.0	0.2	-1.3	-1.0	-1.1
Relative age voice broke	1.4	2.1	5.2	0.3	-0.7	-2.0	-0.9	-2.3
Taking other prescription medications	0.9	1.4	4.5	-2.1	1.1	-0.9	0.5	-0.7
Age when periods started (menarche)	2.2	5.2	10.4	-0.7	-3.2	-2.5	-2.6	-1.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.6	0.1	0.8	-0.2	0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.8	19.8	4.5	-3.7	0.3	-0.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.6	1.3	-0.1	-0.4	-0.3	-0.7
Qualifications: CSEs or equivalent	0.4	0.5	0.7	0.8	-0.7	0.1	-0.8	-0.8
Serious illness, injury or assault to yourself	2.6	3.1	10.2	-1.4	3.2	1.1	0.6	1.4
High blood pressure	0.4	1.2	4.2	-1.2	0.3	-0.3	2.0	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.9	0.6	-0.8	-1.0	-0.1
Multivitamins +/- minerals	0.8	1.1	3.3	-1.8	0.5	-0.2	1.3	0.3
Stomach or abdominal pain in last month	2.4	3.0	5.5	-0.8	-0.6	2.4	1.9	2.2
Supplements: Glucosamine	1.3	1.7	5.9	0.9	2.4	0.8	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	4.0	-2.0	-0.4	0.0	0.1	-0.2
Medication: Atenolol	0.9	1.1	3.0	1.0	-0.9	0.3	1.7	0.7
Medication: Levothyroxine sodium	1.4	2.4	10.0	-1.3	3.2	-0.1	0.3	0.4
Sitting height	0.0	0.3	1.0	0.2	-1.0	0.0	0.0	0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	0.9	1.1	-0.7	0.0	-0.4
High blood pressure (mother)	0.3	0.4	0.8	-0.8	0.1	0.8	0.9	0.3
Body mass index (BMI)	2.1	8.9	15.5	-3.1	3.4	2.1	3.9	1.9
Impedance of leg (left)	2.1	10.4	26.0	3.8	-5.1	-2.0	-1.9	-1.9
Leg predicted mass (left)	0.9	5.0	8.0	-2.1	2.8	1.8	2.4	1.8
Trunk fat mass	1.0	4.4	13.2	-1.8	1.7	1.3	3.6	1.1
Waist circumference	1.9	7.1	16.1	-2.4	2.9	1.6	4.0	1.6
Number of incorrect matches in round	0.3	0.6	1.2	1.1	0.8	-0.9	0.4	-0.5
Past tobacco smoking	0.4	0.7	1.7	-0.5	0.6	0.7	1.3	1.0
Alcohol usually taken with meals	0.2	0.3	1.1	-1.1	-0.2	0.4	0.4	0.1
Nervous feelings	0.7	1.4	2.8	1.7	0.5	-0.9	-1.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	0.8	-0.3	-1.0	-0.8	-0.9
Hearing difficulty/problems with background noise	1.9	3.0	6.4	-0.6	2.5	1.5	2.2	1.0
Hair/balding pattern: Pattern 2	1.3	1.7	3.4	1.2	-0.6	-1.4	-1.9	-1.1
Had menopause	0.6	0.8	3.1	0.3	1.8	-0.4	-0.7	-0.4
Had other major operations	1.0	1.2	4.0	0.2	2.0	0.3	1.4	0.3
Forced vital capacity (FVC)	1.3	5.2	17.2	2.7	-4.2	0.8	-0.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	24.8	5.0	-4.1	0.4	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	0.7	1.0	-1.3	-1.0	-1.2
Qualifications: None of the above	0.4	0.8	2.7	1.6	-0.7	-0.7	0.2	-0.3
Financial difficulties in last 2 years	0.5	0.6	2.4	-1.6	-0.1	0.2	0.8	-0.2
Mouth/teeth dental problems	0.5	0.8	2.9	-0.4	-0.8	-0.4	-1.7	-0.4
Heart attack	1.1	1.4	4.8	-1.0	-0.3	0.6	2.2	0.9
Allergy	0.4	0.9	1.6	0.5	-1.2	1.0	0.9	0.8
Pain all over the body in last month	0.6	0.7	1.5	0.6	0.4	-1.1	-0.6	-1.2
Diabetes (self-reported)	2.3	3.6	7.2	-2.7	0.4	1.2	2.7	1.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.0	-0.1	-0.8	-0.8	-0.2
Medication: Ramipril	0.4	0.5	1.0	0.5	-0.7	0.6	0.5	1.0
Medication: Simvastatin	0.9	1.3	3.2	0.3	-1.1	-1.8	-0.5	-1.3
Fluid intelligence score	0.2	0.4	0.9	0.3	-1.0	0.7	0.7	0.5
Illnesses of siblings	0.7	0.9	2.3	0.2	0.8	1.5	0.6	1.1
Neuroticism score	0.1	0.1	0.3	-0.0	0.2	0.5	0.5	0.1
Weight	1.0	5.2	11.6	-1.6	2.4	1.7	3.4	1.7
Impedance of arm (right)	1.2	5.5	7.8	2.8	-2.7	-2.3	-1.9	-1.9
Arm fat percentage (right)	1.5	6.0	15.2	-2.3	2.3	1.5	3.9	1.3
Trunk fat-free mass	0.5	3.2	4.3	-0.3	1.9	1.9	2.0	2.1
Hip circumference	1.0	4.3	9.9	-1.4	2.0	1.8	3.1	1.6
Time employed in main current job	0.5	0.5	1.1	-0.9	1.1	0.6	0.4	0.3
Alcohol intake versus 10 years previously	0.6	0.9	3.0	-0.6	-1.7	-1.1	0.1	-0.5
Father’s age at death	0.1	0.2	0.5	0.2	0.4	-0.1	-0.7	-0.5
Worrier / anxious feelings	0.4	0.8	1.2	0.9	0.2	1.1	1.0	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.4	-0.2	-0.4	-0.1	-0.7
Falls in the last year	0.2	0.3	1.0	-0.7	0.2	-0.2	1.0	-0.2
Hair/balding pattern: Pattern 3	0.2	0.4	0.9	-0.1	0.4	0.8	-0.1	0.9
Number of live births	0.4	0.6	1.4	1.2	0.6	-0.3	1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	13.7	1.8	-3.7	1.0	-0.2	1.2
Pulse rate	0.9	1.6	4.0	-2.0	0.8	0.3	1.6	0.7
Happiness	1.0	1.2	1.5	1.1	-1.2	-1.1	-1.0	-1.1
Noisy workplace	3.1	3.9	5.2	-1.6	2.1	2.1	1.6	2.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	0.7	-0.1	1.0	0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	0.3	-0.5	-1.5	-0.9	-1.2
Mouth/teeth dental problems: Dentures	2.0	3.4	9.9	-0.3	-0.8	1.6	3.1	2.0
Asthma	0.1	0.2	0.9	0.1	0.9	-0.2	-0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.5	1.1	1.0	-0.1	-1.2	-0.6
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.9	-0.5	0.2	0.9	0.8
Depression (self-reported)	2.5	3.0	5.0	1.2	-1.3	-2.2	-1.9	-1.8
Medication: Lansoprazole	1.1	1.3	3.1	-1.8	0.6	-0.8	1.4	-0.6
Prospective memory result	1.2	1.4	3.6	1.9	1.6	0.2	0.9	-0.6
Lung cancer (father)	0.9	1.1	3.1	0.1	1.7	0.1	1.4	0.7
Illnesses of mother	0.3	0.4	1.3	0.3	0.6	0.4	0.5	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	10.2	1.7	-3.2	0.4	-0.7	0.3
Pulse wave Arterial Stiffness index	1.0	1.2	1.8	0.2	1.4	1.2	0.9	1.3
Impedance of arm (left)	1.2	5.8	8.0	2.4	-2.8	-2.5	-2.1	-2.2
Arm fat mass (right)	1.5	6.4	15.7	-2.0	2.3	1.9	4.0	1.7
Trunk predicted mass	0.5	3.1	4.3	-0.4	1.9	1.9	2.0	2.1
Standing height	0.2	2.3	7.9	2.8	-1.8	-0.3	-0.4	0.1
Length of working week for main job	0.9	1.0	2.9	-0.3	-1.7	0.0	1.3	0.2
Exposure to tobacco smoke at home	0.9	1.1	1.9	0.7	-1.1	-0.8	-1.1	-1.4
Breastfed as a baby	1.0	1.3	2.9	-1.7	-0.1	-1.4	-0.9	-0.9
Tense / ‘highly strung’	0.8	1.3	3.1	1.8	0.7	-1.0	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.8	-0.4	-1.3	-0.4	0.2	-0.6
Hair/balding pattern: Pattern 4	1.6	3.9	5.1	1.8	-2.2	2.3	1.9	1.7
Birth weight of first child	0.3	0.5	2.2	1.5	-0.5	-0.1	-0.1	-0.2
Peak expiratory flow (PEF)	0.6	1.5	2.9	0.3	-0.8	1.7	1.0	1.7
Pulse wave reflection index	0.6	0.8	2.4	0.4	0.8	0.9	-0.1	1.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-0.1	0.1	0.8	0.7	1.1
Loud music exposure frequency	2.1	2.3	4.3	-1.8	-0.8	1.4	2.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	-1.2	0.1	0.7	0.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.2	0.9	0.4	-0.0	0.5
Blood clot in the leg (DVT)	0.7	0.9	2.4	-1.0	1.6	0.0	-0.7	-0.6
Medication: Paracetamol	1.1	1.8	4.0	1.0	2.0	1.4	1.0	1.1
Headache pain in last month	0.4	0.6	2.0	-0.9	1.4	0.6	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	4.3	0.7	2.1	0.3	-0.7	0.0
Glaucoma (self-reported)	1.3	1.5	4.1	-0.3	-0.1	-1.1	-2.0	-1.4
Gout (self-reported)	52.8	72.4	163.8	-2.2	-12.8	-7.3	-8.4	-8.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	6.2	-2.5	2.5	-0.7	0.0	-0.3
Medication: Amlodipine	1.5	2.1	4.8	2.2	-2.2	0.4	0.9	0.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.4	1.5	1.5	0.3	1.2	0.2
Birth weight	0.6	1.2	3.1	1.4	-1.8	-0.0	-0.8	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	-1.4	0.3	-0.5	-0.6	-1.0
High blood pressure (siblings)	1.1	1.5	2.0	1.4	-1.2	-1.4	-0.8	-1.2
Forced vital capacity (FVC), Best measure	0.9	3.4	11.6	2.2	-3.4	0.4	-0.6	0.2
Body fat percentage	1.2	4.7	14.5	-1.9	1.6	1.3	3.8	1.0
Leg fat percentage (right)	1.7	6.3	17.8	-2.0	1.9	1.9	4.2	1.5
Arm fat-free mass (right)	0.6	3.1	4.4	-1.2	1.8	1.8	2.1	1.8
Exposure to tobacco smoke outside home	2.6	3.5	7.6	1.3	-1.6	-1.9	-1.3	-2.8
Comparative body size at age 10	0.6	1.7	3.9	-2.0	1.7	0.7	1.1	0.1
Number of full brothers	0.3	0.4	1.2	1.1	-0.3	-0.5	-0.2	-0.7
Worry too long after embarrassment	0.5	0.8	1.9	0.0	-0.3	-1.3	-0.8	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.7	0.8	-0.8	-0.7	-0.7	-0.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.7	0.5	-0.0	-0.1	-0.7
Number of children fathered	1.7	1.9	4.0	-2.0	1.6	0.9	1.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.9	0.6	-1.4	-0.2	-0.7	-0.3
Age at first live birth	2.5	4.5	9.3	-0.5	1.5	3.0	1.5	2.9
Pulse wave peak to peak time	1.2	1.4	2.4	0.2	-1.6	-1.3	-1.0	-1.4
Health satisfaction	0.3	0.4	1.6	-1.2	0.7	-0.0	-0.1	0.2
Shortness of breath walking on level ground	1.3	1.6	3.0	-1.7	1.5	-0.8	-0.8	-1.1
Qualifications: College or University degree	0.1	0.2	0.3	0.6	-0.3	0.2	-0.1	0.6
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.5	-0.8	-0.3	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.8	3.4	1.9	-0.1	0.3	-0.5	-0.1
Emphysema/chronic bronchitis	0.7	0.8	3.3	0.2	1.8	-0.4	0.5	0.5
Medication for pain relief, constipation, heartburn	2.6	4.4	9.2	0.5	-3.0	-1.7	-3.0	-0.9
Neck or shoulder pain in last month	1.2	1.7	6.9	2.6	0.7	0.4	1.0	0.5
Medication: Blood pressure	0.6	1.1	3.1	-0.6	-1.8	-0.1	1.3	-0.3
Angina (self-reported)	0.9	1.2	2.0	0.1	0.8	1.2	1.4	1.4
Migraine (self-reported)	1.3	1.6	5.1	-0.0	-0.1	-1.3	-2.3	-1.1
Medication: Ibuprofen	0.4	0.5	1.1	0.8	0.5	0.1	-1.0	-0.6
Medication: Allopurinol	36.3	48.3	112.4	-1.3	-10.6	-5.7	-6.8	-7.0
Medication: Omeprazole	2.5	2.9	5.4	-2.2	1.6	0.8	2.3	1.2
Medication: Seretide 50 evohaler	0.4	0.5	1.6	0.4	0.5	-0.7	1.2	-0.3
Mean time to correctly identify matches	1.7	3.1	6.6	0.6	-0.5	-2.6	-1.7	-2.4
Heart disease (mother)	0.6	0.7	1.7	-0.8	1.3	0.0	1.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	4.4	1.1	0.1	1.9	1.3	2.1
Whole body fat mass	1.2	5.2	15.5	-1.5	1.9	1.6	3.9	1.5
Leg fat mass (right)	1.8	7.1	17.5	-2.4	2.2	2.1	4.2	1.8
Arm predicted mass (right)	0.6	2.9	4.7	-1.1	1.8	1.7	2.2	1.7
Pulse rate, automated reading	0.7	2.4	6.7	-1.3	1.7	0.2	2.6	0.6
Alcohol intake frequency.	0.4	0.9	2.2	-1.5	-1.2	0.2	0.6	0.6
Comparative height size at age 10	0.2	1.3	2.9	1.7	1.4	-0.3	1.1	0.4
Number of full sisters	1.1	1.3	2.7	-1.3	-1.4	-0.3	-1.6	0.1
Suffer from ‘nerves’	0.6	0.9	4.3	0.1	2.1	-0.0	0.2	-0.2
Overall health rating	0.1	0.3	0.8	-0.2	0.9	-0.2	0.6	-0.3
Chest pain or discomfort	0.3	0.4	0.9	0.8	-0.4	-0.7	0.1	-0.9
Had major operations	0.6	0.7	2.6	-0.0	-0.8	-0.1	-1.6	-0.5
Age at last live birth	1.3	1.9	3.6	1.6	-0.2	1.9	0.9	1.5
Family relationship satisfaction	2.4	2.9	4.8	1.6	-1.5	-1.1	-2.2	-1.9
Leg pain on walking	2.8	3.5	9.5	-2.0	3.1	1.1	1.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	-0.7	-0.9	-0.4	-0.3	-0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.4	-1.6	2.1	-0.5	-0.4	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.8	0.9	-1.4	-1.2	-1.2	-0.9
Medication: Aspirin	1.7	2.2	7.4	-0.4	1.2	1.2	2.7	0.8
Supplements: Vitamin C	0.4	0.4	1.4	1.2	0.8	-0.0	0.1	-0.4
Knee pain experienced in last month	1.3	2.0	4.2	0.9	1.0	1.6	1.2	2.1
Hypertension (Self-reported)	0.6	1.5	4.8	-1.5	0.3	-0.0	2.2	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	-1.0	0.4	-0.5	0.6	-0.4
Illnesses of father: Heart disease	1.5	2.1	5.5	0.9	-0.9	2.3	1.0	1.6
Illnesses of siblings: Diabetes	0.7	0.8	1.9	0.5	-0.7	-1.4	-0.9	-0.9
Smoking status: Previous	0.4	0.7	1.8	-0.3	-0.6	-0.7	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.8	-0.8	-0.3	0.9	-0.9	0.6
Whole body fat-free mass	0.6	3.6	5.1	-1.0	2.3	1.8	2.2	2.0
Leg fat-free mass (right)	0.7	3.7	5.9	-1.7	2.4	1.7	2.0	1.7
Arm fat percentage (left)	1.6	6.3	15.4	-2.4	2.3	1.7	3.9	1.5
Average weekly red wine intake	0.5	0.8	1.7	1.3	1.2	-0.4	-0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	0.8	-0.1	0.9	1.4	0.6
Mood swings	0.9	1.6	5.1	-0.7	1.1	-1.2	-0.0	-2.2
Loneliness, isolation	0.9	1.3	4.7	1.3	-2.2	0.1	-0.0	-0.4
Long-standing illness, disability or infirmity	0.5	0.7	1.0	0.5	0.4	1.0	1.0	1.0
Ever had bowel cancer screening	2.5	3.0	9.5	-1.2	3.1	-1.0	0.3	-1.7
Diabetes diagnosed by doctor	2.6	4.3	10.2	-2.2	0.6	1.7	3.2	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	0.1	0.5	0.2	-0.2
Friendships satisfaction	1.2	1.5	6.9	2.6	-0.0	0.6	0.3	-0.1
Qualifications: nursing, teaching	1.0	1.6	3.6	-1.2	1.0	-0.9	-1.9	-1.1
Commuting to job workplace: Walk	0.9	1.0	2.8	0.5	-0.5	-1.0	-0.6	-1.7
Eye problems/disorders: Cataract	0.2	0.2	0.8	0.2	0.9	-0.2	0.3	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	0.5	1.0	-0.2	0.4	-0.3
Medication for cholesterol	0.2	0.3	0.6	0.7	-0.5	0.8	-0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.2	-0.4	1.1	-0.2	0.0	0.1
Back pain experienced in last month	0.2	0.3	0.7	-0.2	0.9	-0.4	-0.6	-0.1
Mineral and other dietary supplements	0.9	1.2	2.7	-0.5	-1.2	-0.8	-0.8	-1.7
Breast cancer (self-reported)	1.7	2.0	5.2	0.8	2.3	1.2	1.1	1.2
Asthma (self-reported)	0.1	0.1	0.6	0.0	0.8	-0.0	-0.3	-0.1
Osteoporosis (self-reported)	1.2	1.5	6.4	-2.5	-0.5	-0.2	-1.0	-0.2
Osteoarthritis (self-reported)	2.9	3.7	14.0	3.7	2.0	-0.1	0.8	0.1
Medication: Aspirin	1.5	2.0	6.6	0.2	0.8	1.3	2.6	0.9
Medication: Gliclazide	0.8	0.9	2.2	-1.5	-1.1	-0.3	0.9	-0.6
Illnesses of father: None of the above (group 1)	0.6	0.8	1.7	-0.8	0.6	-0.8	-1.3	-0.7
Smoking status: Current	0.2	0.4	0.7	0.8	-0.6	-0.6	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.9	0.9	-1.7	-0.4	0.1	-0.2
Whole body water mass	0.7	3.8	5.9	-1.1	2.4	1.8	2.2	1.9
Leg predicted mass (right)	0.7	3.9	6.0	-1.7	2.4	1.8	2.1	1.8
Arm fat mass (left)	1.5	6.1	14.6	-2.0	2.3	1.9	3.8	1.8
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	-0.9	0.4	0.0	0.3	0.3
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-1.2	-0.5	-0.0	-0.5	0.5
Miserableness	0.4	0.7	1.4	-0.1	-1.2	-0.7	-0.5	-1.1
Guilty feelings	0.1	0.2	0.8	0.9	-0.3	0.1	-0.2	-0.4
Wears glasses or contact lenses	0.9	1.0	1.6	0.1	1.1	1.3	1.0	1.1
Ever taken oral contraceptive pill	2.0	2.2	4.9	-0.8	2.2	1.3	1.6	1.2
Hearing aid user	1.3	1.5	3.8	-0.9	-0.6	1.0	2.0	1.3
Mother’s age at death	2.1	2.6	5.5	2.3	-1.8	-0.3	-1.7	-1.2
Financial situation satisfaction	0.2	0.3	0.9	-0.1	-1.0	-0.3	-0.3	-0.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.3	-0.0	0.7	1.5	1.4	1.3
Commuting to job workplace: Public transport	2.5	2.9	4.2	2.0	-1.1	1.8	2.0	1.4
Eye problems/disorders: Glaucoma	1.0	1.1	3.2	-1.3	0.9	-0.3	-1.8	-0.0
Medication: Blood pressure	1.0	1.8	3.6	-0.3	1.9	0.8	1.7	1.5
Pain type(s) experienced in last month: Hip pain	2.5	3.1	10.6	0.1	3.3	1.2	1.5	1.2
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.2	1.8	0.4	1.2	1.1	1.4
High cholesterol (Self-reported)	0.2	0.3	1.2	0.1	-1.1	-0.4	0.4	0.0
Medication: Bendroflumethiazide	1.5	2.3	4.0	-0.7	2.0	1.7	1.3	1.6
Medication: Paracetamol	0.8	1.2	2.5	0.2	1.6	1.4	0.7	1.1
Medication: Lisinopril	0.1	0.2	0.5	-0.3	-0.1	-0.3	-0.1	-0.7
Medication: Atorvastatin	2.5	3.1	5.1	-1.8	-0.1	1.9	2.2	1.9
Illnesses of father: High blood pressure	0.7	0.8	1.5	0.4	-0.8	1.2	1.2	0.5
Alcohol drinker status: Never	1.1	1.3	3.4	0.1	-0.8	-1.8	-0.4	-1.5
Ever smoked	1.0	1.8	2.8	0.7	-1.3	-1.3	-1.7	-1.5
Basal metabolic rate	0.8	4.2	6.5	-1.3	2.4	1.9	2.5	2.0
Leg fat percentage (left)	1.6	5.8	17.6	-1.8	1.6	1.9	4.2	1.4
Arm fat-free mass (left)	0.6	3.1	5.1	-1.0	1.9	1.7	2.3	1.7
Number of operations (self-reported)	0.8	1.2	3.4	0.1	1.8	0.9	1.0	1.1
Average weekly beer plus cider intake	0.7	1.1	2.0	0.9	0.1	-1.1	-1.1	-1.4
Irritability	0.3	0.5	1.3	0.2	1.1	1.1	0.3	-0.0
Risk taking	1.8	2.6	5.3	-1.6	0.2	-1.9	-1.1	-2.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.7	-1.9	0.9	0.6	1.3	1.0
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.4	-0.5	0.9	-0.0	0.4
Age started oral contraceptive pill	0.2	0.3	0.5	-0.6	0.5	-0.7	-0.4	-0.5
Diastolic blood pressure, automated reading	0.3	1.1	1.9	-1.4	0.9	-1.1	1.0	-0.5
Ever depressed for a whole week	1.2	1.4	3.6	0.3	1.9	-1.3	-0.5	-1.2
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.3	0.3	-0.1	0.1	0.3
Commuting to job workplace: Cycle	0.8	1.0	3.4	0.5	-0.3	-1.0	-1.9	-0.6
Myopia	0.5	0.7	3.1	-1.8	0.1	0.2	0.6	-0.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	5.4	1.7	-0.5	0.1	-2.3	-0.6
Cholesterol lowering medication	0.5	0.8	1.1	-0.8	-1.1	-1.0	0.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.8	-1.9	1.4	0.0	2.2	0.7
Pain experienced in last month	0.2	0.4	1.6	-0.2	-1.3	-0.4	0.1	-0.2
Supplements: Calcium	2.0	2.2	8.1	-1.4	2.8	0.9	0.2	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.3	-0.4	0.6	0.8	0.3
Heart attack/myocardial infarction (self-reported)	1.2	1.6	5.2	-0.9	-0.2	0.8	2.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.2	-1.1	1.5	-0.5	-1.0	-1.1
Heart disease (siblings)	0.9	1.1	5.0	-2.2	0.5	0.3	0.6	-0.1
Alcohol drinker status: Previous	0.5	0.6	2.2	-1.5	0.7	0.2	-0.3	0.0
Pack years of smoking	0.5	0.8	1.7	-0.2	1.2	0.0	1.3	0.7
Impedance of whole body	1.8	9.1	18.4	3.3	-4.3	-2.4	-2.3	-2.3
Leg fat mass (left)	1.7	6.6	17.1	-2.1	1.9	2.1	4.1	1.8
Arm predicted mass (left)	0.8	3.8	5.9	-1.0	2.1	2.0	2.4	2.0