Hub : Genes

PKD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1710	0.0370	1.4e-11	0.104	0.121	0.155	0.144	0.149	1.3e-12	1.6e-14	2.1e-18	3.8e-17	1.1e-17
2	GTEx	Testis	0.4470	0.0620	6.0e-13	0.476	NA	0.424	NA	0.473	1.4e-23	NA	2.0e-20	NA	2.1e-23
3	ROSMAP	Brain Pre-frontal Cortex	0.1110	0.0257	5.7e-12	0.089	0.098	0.102	0.105	0.112	1.5e-11	1.4e-12	4.7e-13	2.4e-13	3.3e-14
4	YFS	Blood	0.2985	0.0347	0.0e+00	0.073	0.189	0.218	0.253	0.171	1.2e-22	1.4e-59	1.1e-69	2.8e-82	1.0e-53
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0676	0.0406	2.4e-03	0.013	0.021	0.012	NA	0.014	1.2e-02	2.0e-03	1.4e-02	NA	9.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.6	0.3	0.4	-0.9	-0.4	1.3
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.2	0.4	-0.1	0.2	0.1
Depressed Affect (Nagel 2018)	0.5	1.0	2.0	-1.1	-1.4	-0.8	0.5	-1.0
Depression (Nagel 2018)	1.1	1.7	3.1	-1.8	-1.4	-1.3	1.1	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.3	-1.5	-0.8	-0.6	0.1	-0.3
Neuroticism (Nagel 2018)	1.4	3.2	6.6	-1.6	-2.4	-2.6	-0.9	-0.6
Schizophrenia (2018)	0.1	0.3	0.7	-0.0	0.2	0.6	0.5	-0.8
Schizophrenia vs Biploar Disorder	0.7	1.0	2.3	0.7	1.5	1.2	0.7	0.4
Worry (Nagel 2018)	3.1	6.4	13.9	-1.7	-3.4	-3.7	-1.8	-0.7
Alzheimer’s Disease (in mother)	1.0	1.1	3.3	-1.0	-1.8	-0.9	-0.2	-0.6
Alzheimer’s Disease (in father)	0.4	0.4	1.0	1.0	1.0	0.4	0.1	0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.3	-0.2	0.4	-0.1	-0.2
Crohns Disease (2017)	0.2	0.3	1.2	-0.2	-0.3	0.5	1.1	-0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-0.2	-0.1	0.7	1.4	-0.0
Ulcerative Colitis (UC)	0.2	0.4	1.9	-0.0	-0.0	0.6	1.4	-0.0
Major Depression (MDD)	0.4	0.5	1.0	-0.6	-0.6	-0.6	0.5	-1.0
Reaction Time	0.3	0.6	1.1	1.1	0.6	0.4	-1.0	-0.5
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	-0.2	0.3	0.2	0.2	-0.2
Breast Cancer	3.3	7.9	20.2	-1.9	-0.8	2.2	3.2	-4.5
Ovarian Cancer	0.1	0.2	0.3	-0.5	-0.6	-0.6	0.2	0.1
Prostate Cancer	1.8	2.5	6.2	-1.7	-1.5	-2.5	-0.9	0.5
Age at First Birth	1.0	1.5	3.1	-1.8	-0.7	-1.8	-0.7	0.6
Bipolar Disorder (2011)	0.2	0.1	0.5	-0.3	0.2	-0.3	-0.0	-0.7
Body Mass Index (BMI) (2010)	0.9	1.3	2.9	0.0	-0.9	-1.7	-1.5	0.8
Coronary Artery Disease (CAD)	2.6	3.2	6.4	-2.4	-1.7	-2.5	0.7	0.4
Crohns Disease (2012)	1.0	1.6	2.4	1.6	1.6	1.4	0.8	0.7
Mean Putamen Volume	0.3	0.4	0.9	0.9	0.1	0.5	-0.8	-0.0
Fasting Glucose	1.0	1.2	4.4	-0.3	-1.1	0.4	-0.4	-2.1
HbA1C	0.1	0.1	0.5	0.0	-0.4	-0.1	0.1	-0.7
HDL Cholesterol	1.3	2.1	6.6	1.1	1.6	0.3	-0.5	2.6
LDL Cholesterol	0.5	0.8	2.6	0.3	0.4	0.6	0.7	-1.6
Lupus	1.2	1.8	3.7	-1.0	-1.4	-1.9	-1.5	0.3
Neuroticism (2016)	0.6	0.8	2.7	0.1	-0.9	-1.6	-0.4	-0.6
Primary Biliary Cirrhosis	0.5	0.7	1.3	1.1	0.3	1.1	-0.5	-0.8
Rheumatoid Arthritis	0.1	0.1	0.2	0.2	0.5	0.0	0.0	0.4
Schizophrenia (2014)	0.4	0.9	2.5	0.6	1.6	0.8	0.9	0.3
Triglycerides	0.7	1.2	3.5	-1.2	-1.1	0.1	0.3	-1.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	0.1	0.1	0.9	1.0	0.5
Ulcerative Colitis	0.1	0.1	0.3	0.2	0.4	0.0	0.0	0.6
Blood Eosinophil Count	0.0	0.2	0.5	-0.4	0.5	0.7	0.2	0.0
Blood Platelet Count	0.2	2.8	5.4	2.3	2.0	1.2	-1.5	1.0
Blood Red Count	0.1	1.1	3.5	-1.9	-1.1	-0.4	-0.1	0.9
Blood White Count	0.4	3.2	6.4	2.5	1.9	1.3	-1.5	1.5
Heel T-Score	6.0	47.9	98.6	6.3	8.3	9.9	3.3	4.7
BMI	0.5	3.1	8.9	-0.4	1.0	-2.0	-1.3	3.0
Height	0.1	2.0	4.7	2.2	-0.0	1.6	0.8	-1.4
Waist Hip Ratio (WHR)	0.1	0.3	0.8	0.2	-0.6	0.1	-0.4	-0.9
Systolic Blood Pressure	0.1	0.6	1.4	1.1	0.5	1.2	-0.2	0.2
Smoking Status	0.4	0.9	1.7	1.3	1.0	1.3	-0.3	0.0
Allergy or Eczema	0.1	0.3	0.9	0.5	0.9	-0.1	0.4	0.6
Cardiovascular Disease	0.3	1.1	2.6	1.0	1.2	1.6	-0.8	0.2
Hypothyroidism (self reported)	3.5	8.1	15.9	-3.2	-3.4	-4.0	-1.3	-0.9
Respiratory disease	0.3	0.6	1.3	0.6	-0.8	-0.1	-1.1	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.4	1.0	0.8	1.2	-0.6	-0.7
Lung FEV1/FVC ratio	0.1	0.3	1.2	1.1	0.5	0.1	-0.1	0.3
Lung FVC	1.2	6.0	11.8	2.0	3.0	3.4	2.3	0.2
Neuroticism	1.3	3.1	7.0	-1.7	-2.3	-2.6	-0.5	-0.2
Chronotype (morning person)	0.6	1.3	2.7	1.6	1.1	1.0	0.8	1.0
Hair Pigment	0.1	2.5	4.9	1.9	1.4	0.6	-2.2	1.3
Tanning	0.2	2.1	5.3	1.2	0.8	-1.5	-1.1	2.3
Hand grip strength (left)	1.6	4.3	10.0	-3.2	-1.6	-1.7	1.4	-2.0
Number of treatments/medications taken	0.5	0.8	2.5	-0.3	-1.6	-0.5	-1.0	-0.6
Average weekly spirits intake	0.6	0.8	2.2	-0.9	-0.5	-0.5	-0.8	1.5
Sensitivity / hurt feelings	0.6	1.1	2.1	-1.4	-0.7	-0.0	1.4	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.8	-1.2	-0.7	0.0	-0.4
Hearing difficulty/problems: Yes	1.3	1.9	4.4	0.5	-1.1	-1.8	-2.1	0.7
Relative age of first facial hair	0.3	0.6	2.3	-0.1	-0.5	0.1	0.7	-1.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	-0.2	-0.4	-1.2	-0.8	0.8
Ever used hormone-replacement therapy (HRT)	2.2	2.9	5.8	-0.5	-0.5	-2.4	-2.2	1.7
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	0.0	0.1	-0.5	1.6	0.7
Systolic blood pressure, automated reading	0.2	0.7	1.6	-0.7	0.1	-0.8	0.7	1.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.0	0.1	-0.7	0.7	0.4
Angina	0.6	0.8	1.4	0.4	1.1	-0.0	1.1	1.2
Medication for hormone replacement therapy	1.4	1.6	3.9	-0.5	-2.0	-1.1	-1.0	-1.3
Vitamin and mineral supplements	0.2	0.2	0.4	0.4	0.2	0.4	-0.6	-0.6
Supplements: Zinc	0.6	0.7	1.8	-0.4	0.3	-0.8	0.7	1.4
Medication: Co-codamol	0.9	1.0	1.7	-1.3	-1.3	-1.0	-0.0	-0.9
Medication: Metformin	0.8	1.1	3.4	-1.0	-0.5	0.4	1.9	-0.9
Diabetes (father)	0.8	1.0	2.1	1.3	0.5	-0.3	-0.9	1.4
Diabetes (mother)	0.2	0.3	1.2	-0.1	0.3	-0.1	0.1	1.1
Severe depression (siblings)	0.5	0.5	1.2	0.6	0.2	0.1	-0.9	1.1
Pack years adult smoking proportion	1.9	2.9	6.4	1.9	1.9	0.4	-1.0	2.5
Impedance of leg (right)	0.9	4.6	12.0	1.8	-0.5	3.5	0.3	-2.7
Leg fat-free mass (left)	0.3	1.8	5.2	-0.7	0.3	-2.3	-0.1	1.8
Trunk fat percentage	0.3	1.1	3.9	0.7	0.9	-0.5	-0.2	2.0
Hand grip strength (right)	0.4	1.1	2.2	-1.5	-0.4	-1.1	0.3	-1.3
Townsend deprivation index at recruitment	1.1	1.6	4.6	1.5	0.7	2.2	-0.4	-0.5
Current tobacco smoking	0.5	0.8	1.6	1.3	0.3	0.7	-1.2	0.8
Average weekly fortified wine intake	0.3	0.3	1.2	-0.6	-0.4	-0.2	-0.1	1.1
Maternal smoking around birth	0.5	0.7	1.6	-0.8	-1.0	-1.3	-0.3	0.6
Fed-up feelings	0.1	0.2	0.4	-0.6	-0.5	-0.5	0.3	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.5	-1.0	-1.6	-0.5	-0.2	-1.5
Relative age voice broke	0.7	1.1	3.2	0.6	1.1	0.5	1.8	-0.3
Taking other prescription medications	1.9	2.9	5.4	-0.3	-2.3	-1.1	-1.7	-2.3
Age when periods started (menarche)	0.8	1.9	7.1	-0.8	-0.5	0.7	1.1	-2.7
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.1	-1.7	-1.1	-1.8	1.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	4.9	11.2	30.2	3.8	3.3	5.5	-0.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	-1.3	-0.9	-1.1	0.1	-0.8
Qualifications: CSEs or equivalent	1.8	2.3	5.3	-1.5	-2.3	-0.8	-1.7	-0.9
Serious illness, injury or assault to yourself	3.5	4.3	8.2	-1.8	-2.4	-2.9	-1.9	0.6
High blood pressure	0.1	0.3	1.1	0.1	1.0	0.8	0.1	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.1	0.7	-0.3	0.4	0.4
Multivitamins +/- minerals	0.1	0.1	0.4	-0.1	-0.6	-0.4	-0.2	0.1
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.9	0.6	0.9	-0.2	-0.3
Supplements: Glucosamine	2.2	2.9	9.5	1.0	0.8	-1.4	-1.2	3.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.3	0.8	0.0	0.3	-1.8	1.0
Medication: Atenolol	0.5	0.6	1.8	0.4	0.0	1.3	0.6	-0.8
Medication: Levothyroxine sodium	3.7	6.2	11.2	-2.6	-3.0	-3.4	-2.0	-0.4
Sitting height	0.2	1.3	2.8	1.7	0.8	0.6	1.6	-0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	1.2	0.3	0.1	-0.6	0.0
High blood pressure (mother)	0.2	0.2	0.5	-0.1	-0.1	0.5	0.5	0.7
Body mass index (BMI)	0.6	2.4	5.6	-0.3	0.7	-2.0	-1.2	2.4
Impedance of leg (left)	0.9	4.3	10.7	1.4	-1.2	3.3	0.4	-2.7
Leg predicted mass (left)	0.4	1.9	5.6	-0.9	0.2	-2.4	-0.2	1.8
Trunk fat mass	0.2	1.0	3.5	0.3	0.6	-1.1	-0.4	1.9
Waist circumference	0.3	1.1	3.1	-0.6	-0.1	-1.7	-0.4	1.3
Number of incorrect matches in round	0.4	0.7	1.2	1.0	0.9	0.3	-0.5	1.1
Past tobacco smoking	0.4	0.7	1.2	-1.1	-1.0	-0.9	0.4	0.7
Alcohol usually taken with meals	0.1	0.1	0.5	0.4	0.7	-0.0	-0.0	-0.2
Nervous feelings	0.9	1.6	3.5	-0.9	-1.9	-1.8	-0.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.4	-1.3	-2.3	-1.4	0.3	-1.4
Hearing difficulty/problems with background noise	1.7	2.7	5.5	0.1	-2.1	-1.5	-2.3	-1.0
Hair/balding pattern: Pattern 2	0.5	0.7	1.4	-0.3	-0.9	0.8	0.5	-1.2
Had menopause	1.0	1.3	4.6	-0.9	-0.9	-2.1	0.1	0.5
Had other major operations	0.3	0.4	0.9	1.0	0.7	-0.1	-0.4	0.4
Forced vital capacity (FVC)	2.2	8.6	20.2	2.7	2.4	4.5	2.8	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	5.2	11.9	32.8	3.5	3.6	5.7	0.3	1.0
Ever unenthusiastic/disinterested for a whole week	3.8	4.7	9.7	-2.2	-3.1	-1.8	-1.6	-1.7
Qualifications: None of the above	1.0	2.2	6.0	2.5	0.8	1.9	-0.3	-0.7
Financial difficulties in last 2 years	0.6	0.9	1.9	-1.4	-1.1	-0.7	0.1	-0.9
Mouth/teeth dental problems	0.5	0.8	1.3	-1.1	-1.2	-0.8	-0.9	-0.5
Heart attack	1.2	1.5	3.0	1.7	1.4	1.4	0.3	0.8
Allergy	0.3	0.7	2.5	-0.5	0.3	0.7	1.6	0.0
Pain all over the body in last month	0.8	0.9	1.3	1.1	0.9	0.5	-0.8	1.1
Diabetes (self-reported)	0.1	0.2	0.5	0.3	0.4	0.2	-0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.5	1.2	1.2	1.0	0.7	-0.9
Medication: Ramipril	0.2	0.3	0.8	0.2	0.6	0.9	0.0	0.5
Medication: Simvastatin	0.4	0.7	2.1	-0.5	-0.2	0.8	0.5	-1.4
Fluid intelligence score	0.6	1.2	4.4	0.1	-0.0	1.1	0.5	-2.1
Illnesses of siblings	0.2	0.3	0.9	0.5	0.2	-0.3	-0.6	0.9
Neuroticism score	1.7	3.6	7.1	-2.2	-2.7	-2.3	0.0	-0.9
Weight	0.2	1.2	3.1	-0.1	0.5	-1.6	-0.4	1.8
Impedance of arm (right)	0.7	3.0	6.7	2.2	1.1	2.6	1.4	-0.6
Arm fat percentage (right)	0.5	1.9	5.0	1.1	1.5	-0.8	-0.6	2.2
Trunk fat-free mass	0.2	1.2	3.8	-1.0	-0.2	-2.0	-0.2	1.0
Hip circumference	0.4	1.7	5.6	-0.5	0.4	-1.5	0.1	2.4
Time employed in main current job	0.2	0.2	0.4	-0.6	-0.2	-0.6	0.2	-0.3
Alcohol intake versus 10 years previously	0.6	0.9	2.4	-0.2	-0.2	1.4	-0.4	-1.5
Father’s age at death	0.6	0.8	1.6	1.3	0.4	0.1	-1.2	0.8
Worrier / anxious feelings	0.1	0.2	0.7	0.2	-0.5	-0.8	-0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.5	-0.4	-0.2	-0.9	-0.2
Falls in the last year	0.2	0.3	0.7	-0.7	-0.3	0.1	0.5	-0.8
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	1.3	0.4	0.1	-1.2	0.8
Number of live births	1.3	1.8	4.0	2.0	1.3	1.1	-0.5	1.4
Forced expiratory volume in 1-second (FEV1)	2.2	7.3	16.6	2.5	2.2	4.1	2.4	-1.7
Pulse rate	0.9	1.5	4.8	-0.5	-0.5	-0.7	-2.2	1.3
Happiness	0.6	0.8	2.1	0.8	-0.4	0.7	-1.5	0.7
Noisy workplace	0.7	0.9	2.3	-0.7	-0.2	-1.5	0.7	1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.6	0.8	0.7	-0.6	-0.9	2.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	0.0	-0.5	-0.4	-0.1	-1.1
Mouth/teeth dental problems: Dentures	3.1	5.2	6.8	2.2	2.5	2.3	2.6	1.6
Asthma	0.4	0.8	3.3	0.6	-0.6	-0.3	-1.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.5	-0.1	-0.7	-1.0	-1.6	0.4
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.1	-0.4	-0.1	-0.6	-0.9
Depression (self-reported)	1.2	1.5	3.5	-1.3	-1.9	-0.8	0.3	-1.3
Medication: Lansoprazole	0.3	0.3	1.1	0.0	-0.3	-0.2	1.1	-0.6
Prospective memory result	1.7	2.1	6.5	1.5	0.2	-1.0	-2.6	0.8
Lung cancer (father)	1.6	1.9	7.0	-0.1	1.0	-1.0	0.8	2.7
Illnesses of mother	0.4	0.6	1.5	-0.6	-0.3	-0.8	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	9.5	1.6	1.4	3.1	1.1	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	0.0	-0.6	-0.8	-1.4	0.5
Impedance of arm (left)	0.5	2.2	5.5	1.9	0.4	2.4	0.9	-1.1
Arm fat mass (right)	0.3	1.4	3.9	0.4	0.9	-1.3	-0.4	2.0
Trunk predicted mass	0.2	1.1	3.7	-1.0	-0.3	-1.9	-0.2	0.9
Standing height	0.1	0.9	2.5	0.6	-0.1	0.9	1.6	-1.0
Length of working week for main job	0.7	0.8	2.3	0.1	0.0	1.5	0.8	-0.9
Exposure to tobacco smoke at home	0.4	0.4	0.7	0.8	0.4	0.8	-0.0	0.8
Breastfed as a baby	0.5	0.7	2.4	-0.2	0.8	0.5	-0.3	1.5
Tense / ‘highly strung’	2.8	4.7	9.6	-0.6	-3.1	-2.5	-2.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	-0.4	0.1	0.3	-0.7
Hair/balding pattern: Pattern 4	2.5	6.2	12.6	1.8	2.8	3.5	2.6	-0.7
Birth weight of first child	0.1	0.2	0.4	-0.4	-0.4	-0.4	0.6	-0.3
Peak expiratory flow (PEF)	0.8	1.7	3.7	1.9	1.2	1.7	0.8	0.0
Pulse wave reflection index	0.1	0.1	0.2	0.4	0.4	0.1	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.3	-1.8	-1.7	-1.5	-0.4	-0.3
Loud music exposure frequency	0.9	1.0	2.6	0.4	0.2	1.0	1.1	-1.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.9	-2.2	-1.7	-1.8	0.7	0.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.5	-1.5	-1.3	-1.6	-0.3	0.3
Blood clot in the leg (DVT)	2.0	2.6	4.3	-2.1	-1.8	-1.9	-1.4	-0.4
Medication: Paracetamol	1.2	2.0	3.7	-0.5	-1.9	-1.9	-1.5	0.7
Headache pain in last month	1.5	2.6	4.7	-2.2	-1.9	-2.2	-0.5	-0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.1	-0.2	-0.4	-1.4	0.1	1.8
Glaucoma (self-reported)	0.2	0.2	0.5	0.3	-0.5	0.2	-0.7	-0.3
Gout (self-reported)	57.0	78.1	256.0	-6.2	-6.4	6.3	4.0	-16.0
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	12.8	-3.4	-3.6	-3.5	-0.6	-1.8
Medication: Amlodipine	0.7	1.0	3.4	0.5	0.7	1.9	1.0	-0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.3	4.1	2.0	0.8	0.4	-1.2	0.7
Birth weight	1.3	2.9	6.6	1.2	2.6	1.8	1.2	1.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	-0.3	-0.7	-0.8	0.4	-0.1
High blood pressure (siblings)	0.2	0.2	0.8	-0.1	0.5	0.9	0.3	-0.2
Forced vital capacity (FVC), Best measure	1.2	4.4	12.7	2.2	1.7	3.6	1.0	-0.6
Body fat percentage	0.3	1.2	4.0	0.7	0.9	-0.6	-0.5	2.0
Leg fat percentage (right)	0.4	1.4	3.2	1.1	0.9	-0.3	-1.3	1.8
Arm fat-free mass (right)	0.3	1.7	5.0	-1.3	-0.6	-2.2	-0.4	1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.1	-0.0	0.9	0.9	1.1	0.9
Comparative body size at age 10	0.6	1.7	6.6	-0.7	0.3	-0.9	-0.5	2.6
Number of full brothers	0.3	0.4	1.1	0.5	-0.6	0.2	1.0	-0.4
Worry too long after embarrassment	0.8	1.4	2.6	-1.6	-1.4	-1.6	0.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.2	-0.6	-0.5	-1.0	-0.3
Wheeze or whistling in the chest in last year	0.6	1.1	3.2	0.6	-0.0	0.1	-1.8	1.3
Number of children fathered	0.1	0.1	0.3	-0.3	0.0	-0.2	0.6	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	-0.4	0.4	-0.1	0.8	-1.2
Age at first live birth	0.4	0.7	1.9	0.0	0.2	-1.0	-1.4	0.9
Pulse wave peak to peak time	0.5	0.6	1.9	-0.0	0.4	0.8	1.4	-0.6
Health satisfaction	0.4	0.6	1.4	0.7	0.5	-0.2	-1.2	0.8
Shortness of breath walking on level ground	1.5	1.8	6.0	0.2	0.9	-1.1	-1.0	2.5
Qualifications: College or University degree	0.4	1.1	2.2	1.5	1.5	0.3	0.2	1.1
Eye problems/disorders: None of the above	0.3	0.3	1.1	-0.2	-0.3	0.6	0.3	-1.1
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.5	2.1	1.6	0.9	-0.4	1.2
Emphysema/chronic bronchitis	2.5	2.8	13.1	0.7	-0.6	0.2	-3.6	0.3
Medication for pain relief, constipation, heartburn	2.2	3.7	11.7	-0.5	1.1	1.4	3.4	-1.8
Neck or shoulder pain in last month	2.1	3.0	6.8	1.7	0.3	-0.0	-2.6	2.2
Medication: Blood pressure	0.6	1.1	3.2	0.5	1.2	1.8	0.2	-0.9
Angina (self-reported)	0.6	0.8	1.6	0.3	1.1	-0.0	0.9	1.3
Migraine (self-reported)	2.0	2.5	6.7	-1.2	-2.6	-1.5	-1.4	-0.7
Medication: Ibuprofen	0.6	0.8	1.5	-0.3	-0.8	-1.1	-1.2	0.6
Medication: Allopurinol	51.7	68.8	237.2	-5.6	-6.0	5.4	3.2	-15.4
Medication: Omeprazole	0.7	0.8	3.0	0.8	-0.2	-0.1	-1.7	0.6
Medication: Seretide 50 evohaler	1.2	1.4	3.6	1.4	1.9	1.1	0.0	0.4
Mean time to correctly identify matches	0.1	0.3	0.6	0.4	0.8	0.3	0.2	-0.6
Heart disease (mother)	1.7	2.1	4.8	1.7	1.5	0.6	-0.4	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	0.3	-0.6	-0.2	-0.5	-0.3
Whole body fat mass	0.3	1.3	3.9	0.6	0.9	-1.0	-0.5	2.0
Leg fat mass (right)	0.3	1.2	3.1	0.4	0.5	-1.1	-1.0	1.8
Arm predicted mass (right)	0.3	1.3	3.8	-1.1	-0.4	-2.0	-0.3	1.1
Pulse rate, automated reading	0.3	1.1	2.1	0.4	-0.2	-1.4	-1.4	1.1
Alcohol intake frequency.	0.4	0.9	2.5	-0.9	-0.9	0.7	-0.1	-1.6
Comparative height size at age 10	0.2	1.4	3.2	-0.9	-1.2	-1.8	0.9	0.6
Number of full sisters	0.3	0.4	0.7	-0.7	-0.7	-0.2	-0.6	-0.8
Suffer from ‘nerves’	3.2	5.1	10.9	-1.7	-2.9	-3.3	-1.7	0.1
Overall health rating	0.7	1.5	5.6	0.3	-0.9	-0.9	-2.4	0.3
Chest pain or discomfort	2.1	3.0	5.7	2.4	2.1	1.8	0.2	1.3
Had major operations	0.9	1.0	2.6	-1.6	-1.1	-0.5	0.6	-0.9
Age at last live birth	0.7	1.1	2.3	1.5	1.1	0.7	-1.0	0.5
Family relationship satisfaction	1.4	1.8	4.2	-2.1	-1.8	-0.6	-0.8	-0.4
Leg pain on walking	1.9	2.4	5.2	1.7	0.8	-0.5	-2.3	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.8	-1.1	-0.9	0.7	-0.1	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.2	-0.2	-0.4	-1.8	-1.4	0.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.6	0.2	1.2	0.7	1.9	0.8
Medication: Aspirin	0.9	1.2	4.1	0.8	1.1	0.0	-0.6	2.0
Supplements: Vitamin C	1.5	1.8	5.5	-1.1	-0.1	-1.5	-0.1	2.4
Knee pain experienced in last month	1.6	2.6	6.7	2.0	2.6	0.3	0.8	1.2
Hypertension (Self-reported)	0.1	0.4	1.2	0.1	1.1	0.8	-0.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	-0.8	-1.3	-1.3	0.2	-0.1
Illnesses of father: Heart disease	0.8	1.1	1.9	0.6	1.3	0.7	1.1	1.4
Illnesses of siblings: Diabetes	0.7	0.9	1.3	1.1	0.4	1.1	0.8	-1.0
Smoking status: Previous	0.2	0.3	0.8	0.6	0.9	0.5	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.7	0.8	0.4	0.3	0.9	-0.0
Whole body fat-free mass	0.3	1.6	4.9	-1.1	-0.2	-2.2	-0.2	1.4
Leg fat-free mass (right)	0.4	1.9	5.6	-1.0	-0.0	-2.4	0.0	1.7
Arm fat percentage (left)	0.5	1.8	4.8	1.0	1.3	-0.9	-0.9	2.2
Average weekly red wine intake	0.3	0.5	1.2	0.3	0.7	-1.1	0.2	0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.6	1.3	0.3	1.0	-0.9	-0.3
Mood swings	2.3	4.2	7.7	-2.6	-2.3	-2.8	0.7	-1.1
Loneliness, isolation	0.4	0.6	1.2	-0.0	-0.8	1.1	0.1	-1.0
Long-standing illness, disability or infirmity	0.5	0.7	2.0	1.4	-0.1	0.1	-1.2	-0.6
Ever had bowel cancer screening	0.9	1.1	3.4	0.1	-0.3	-1.8	-1.3	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.8	0.8	0.6	0.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	6.4	-0.6	-1.9	-0.5	-0.4	-2.5
Friendships satisfaction	0.4	0.5	1.9	-0.2	0.5	0.2	-0.7	1.4
Qualifications: nursing, teaching	1.4	2.1	5.5	-1.7	-1.4	-2.3	0.3	0.0
Commuting to job workplace: Walk	1.1	1.2	2.0	-1.3	-1.4	-0.9	-0.9	-0.6
Eye problems/disorders: Cataract	1.9	2.2	5.2	1.1	1.9	0.7	-0.8	2.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	1.3	1.2	0.5	-0.5	0.4
Medication for cholesterol	0.1	0.1	0.2	0.4	0.3	0.2	0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	5.8	-2.0	-2.4	-2.0	-0.7	-0.1
Back pain experienced in last month	0.9	1.3	3.0	-0.6	-1.2	-1.7	-1.1	-0.7
Mineral and other dietary supplements	0.5	0.7	2.1	0.3	0.5	1.5	-0.3	-1.0
Breast cancer (self-reported)	3.4	4.0	11.0	2.1	2.1	-0.3	-0.4	3.3
Asthma (self-reported)	0.3	0.6	2.4	0.6	-0.4	-0.3	-1.5	-0.3
Osteoporosis (self-reported)	5.1	6.3	14.6	-3.8	-2.3	-2.7	1.6	-1.5
Osteoarthritis (self-reported)	3.7	4.8	8.8	2.4	1.4	0.4	-2.7	3.0
Medication: Aspirin	0.8	1.0	3.9	0.3	0.8	-0.0	-0.6	2.0
Medication: Gliclazide	0.9	1.0	2.7	-1.0	-0.5	-0.1	1.6	-0.9
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	-1.8	-0.6	-1.4	0.1	-0.2
Smoking status: Current	0.4	0.6	1.2	1.1	0.2	0.8	-1.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	4.9	1.5	1.3	2.2	0.2	0.4
Whole body water mass	0.3	1.7	5.2	-1.1	-0.2	-2.3	-0.2	1.4
Leg predicted mass (right)	0.4	2.0	5.8	-1.1	-0.1	-2.4	0.1	1.6
Arm fat mass (left)	0.4	1.8	5.0	0.7	1.1	-1.2	-0.8	2.2
Number of self-reported non-cancer illnesses	0.8	1.4	4.2	0.4	-0.5	0.3	-1.5	-2.1
Average weekly champagne plus white wine intake	0.9	1.3	2.6	-1.3	-0.4	-0.2	1.6	-1.4
Miserableness	0.4	0.6	2.7	-0.3	-0.7	0.0	0.1	-1.6
Guilty feelings	1.4	2.1	2.9	-1.7	-1.6	-1.5	0.1	-1.7
Wears glasses or contact lenses	1.6	1.8	3.5	1.6	1.9	0.7	1.3	0.9
Ever taken oral contraceptive pill	1.3	1.4	4.0	0.5	0.9	-1.2	-0.8	2.0
Hearing aid user	0.6	0.6	1.2	1.0	0.8	1.1	0.2	-0.5
Mother’s age at death	0.7	0.9	2.0	-0.5	-0.6	0.2	1.4	-1.4
Financial situation satisfaction	0.5	0.6	2.4	-0.2	0.6	1.5	0.5	0.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.5	0.2	0.6	-0.2	-0.7
Commuting to job workplace: Public transport	2.8	3.4	5.3	1.9	2.3	2.3	0.1	1.7
Eye problems/disorders: Glaucoma	0.8	1.0	3.4	-0.3	-0.6	-1.0	-1.8	0.5
Medication: Blood pressure	0.3	0.5	1.1	-0.6	0.1	-0.9	-0.5	1.1
Pain type(s) experienced in last month: Hip pain	2.5	3.2	8.8	-1.0	-1.1	-3.0	-1.8	1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.4	1.6	1.1	0.2	0.8	1.2
High cholesterol (Self-reported)	1.3	2.3	6.7	-1.2	-1.8	0.4	-0.2	-2.6
Medication: Bendroflumethiazide	1.5	2.3	5.6	-1.1	-0.9	-2.4	-1.3	1.4
Medication: Paracetamol	1.1	1.7	3.6	-0.8	-1.7	-1.9	-0.9	1.0
Medication: Lisinopril	0.2	0.2	1.0	0.0	1.0	0.2	0.1	0.5
Medication: Atorvastatin	0.4	0.5	1.1	-0.7	-0.8	-0.3	0.3	-1.1
Illnesses of father: High blood pressure	0.0	0.1	0.1	-0.2	-0.3	0.4	0.2	0.1
Alcohol drinker status: Never	0.1	0.2	0.5	0.2	-0.0	0.2	0.5	-0.7
Ever smoked	0.1	0.1	0.4	0.3	0.4	0.6	-0.2	-0.3
Basal metabolic rate	0.3	1.5	4.5	-0.8	-0.0	-2.1	-0.2	1.4
Leg fat percentage (left)	0.4	1.3	3.6	0.9	0.6	-0.5	-1.2	1.9
Arm fat-free mass (left)	0.2	1.1	3.1	-0.7	-0.2	-1.8	-0.4	1.2
Number of operations (self-reported)	0.4	0.6	1.5	0.2	0.5	-1.0	0.6	1.2
Average weekly beer plus cider intake	0.4	0.7	2.4	-0.1	-0.2	-0.2	-0.9	1.5
Irritability	1.7	2.9	5.2	-1.7	-2.0	-2.3	0.9	-1.3
Risk taking	0.7	1.0	2.6	-1.6	-0.8	-0.9	0.2	-1.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	0.9	0.4	0.6	-0.3	0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.3	1.1	0.2	0.4	0.2	-1.1
Age started oral contraceptive pill	0.4	0.5	1.3	-0.3	-0.6	-0.8	-1.1	-0.2
Diastolic blood pressure, automated reading	0.2	0.6	1.0	-0.9	-0.2	-1.0	-0.5	1.0
Ever depressed for a whole week	3.2	4.0	7.5	-1.7	-2.7	-1.9	-2.0	-1.2
Unable to work because of sickness or disability	0.9	1.2	2.7	-0.4	-1.4	-1.6	-1.0	0.6
Commuting to job workplace: Cycle	0.7	0.9	2.7	-0.7	-0.1	-0.5	1.6	1.0
Myopia	0.8	1.1	2.3	-0.7	0.2	0.7	1.5	-1.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.8	-0.1	-0.9	-0.6	-0.0	-0.1
Cholesterol lowering medication	1.1	1.7	3.4	-1.0	-0.8	0.5	1.7	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.2	-0.3	-0.7	-0.6	-1.1	0.5
Pain experienced in last month	0.9	1.5	3.3	-1.2	0.0	1.4	1.8	-0.9
Supplements: Calcium	4.2	4.6	10.4	-2.4	-2.2	-3.2	-1.4	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.7	0.4	0.2	0.8	-1.3	-0.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.1	1.8	1.5	1.3	0.0	1.1
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	4.5	-2.1	-1.5	-1.7	-1.0	-0.3
Heart disease (siblings)	1.5	1.8	2.6	-1.6	-1.1	-1.4	1.4	-1.0
Alcohol drinker status: Previous	0.6	0.7	2.6	-0.4	-0.5	-0.5	-1.6	-0.5
Pack years of smoking	2.0	3.0	6.8	1.7	2.0	0.4	-1.0	2.6
Impedance of whole body	0.7	3.6	9.8	1.9	-0.3	3.1	0.7	-2.0
Leg fat mass (left)	0.3	1.2	3.4	0.3	0.4	-1.2	-1.0	1.8
Arm predicted mass (left)	0.3	1.3	4.0	-0.9	-0.2	-2.0	-0.1	1.4