Hub : Genes

ABCG2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0465	0.0205	0.00590	0.012	0.014	0.005	0.014	0.007	4.9e-03	3.0e-03	5.1e-02	2.9e-03	2.8e-02
2	NTR	Blood	0.0259	0.0129	0.02000	0.022	0.001	0.013	0.020	0.022	1.0e-07	1.1e-01	3.2e-05	2.9e-07	1.2e-07
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0446	0.0210	0.00052	0.016	0.041	0.031	NA	0.024	5.2e-03	1.8e-05	1.9e-04	NA	8.6e-04
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.1070	0.0470	0.00140	0.033	0.015	0.021	NA	0.050	2.8e-03	3.1e-02	1.3e-02	NA	2.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.2	0.6	-0.1	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	1.2	-1.1	0.7	-0.6
Depressed Affect (Nagel 2018)	0.3	0.5	1.2	0.7	1.1	0.7	0.1
Depression (Nagel 2018)	0.9	1.4	4.3	0.5	-0.5	0.8	2.1
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.2	1.0	-2.1	1.0	0.8
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.7	0.5	-0.2	0.3
Schizophrenia (2018)	1.0	2.0	3.4	1.6	-1.9	1.0	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.9	0.9	-0.4	-0.0	-0.2
Worry (Nagel 2018)	0.1	0.3	0.8	-0.3	0.1	-0.9	0.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.1	0.9	0.8	0.7	1.1
Alzheimer’s Disease (in father)	2.8	3.0	4.6	-1.0	1.8	-1.7	-2.1
Alzheimer’s Disease (including proxy)	0.6	0.9	3.1	0.3	1.7	-0.5	0.0
Crohns Disease (2017)	0.8	1.7	3.3	-1.8	1.6	-0.5	-0.8
Irritable Bowel Disease (IBD)	0.7	1.6	3.1	-1.8	0.5	-1.6	-0.8
Ulcerative Colitis (UC)	0.8	1.5	4.5	-0.9	-0.4	-2.1	-0.8
Major Depression (MDD)	1.4	1.7	3.0	-0.2	-1.3	1.7	1.5
Reaction Time	1.3	2.5	4.8	1.2	-0.3	1.9	2.2
Verbal and Numeric Reasoning (VNR)	0.4	1.1	3.6	-0.1	-1.9	0.6	0.6
Breast Cancer	3.5	8.4	16.2	3.3	-0.2	4.0	2.6
Ovarian Cancer	0.3	0.4	0.7	0.9	0.6	0.7	-0.0
Prostate Cancer	0.3	0.5	1.7	-0.2	-0.1	0.4	-1.3
Age at First Birth	0.1	0.2	0.3	0.5	0.6	0.5	0.2
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.9	0.5	0.0	0.0
Body Mass Index (BMI) (2010)	2.0	2.8	6.1	-2.5	-0.9	-1.9	-0.7
Coronary Artery Disease (CAD)	0.5	0.5	1.0	1.0	-0.1	0.9	0.6
Crohns Disease (2012)	1.2	2.0	3.5	-1.1	1.9	-1.4	-1.2
Mean Putamen Volume	0.9	1.0	2.0	-0.3	1.4	-0.4	-1.4
Fasting Glucose	0.3	0.3	0.9	-1.0	-0.3	0.4	0.2
HbA1C	0.9	1.0	1.7	0.2	1.2	0.9	1.3
HDL Cholesterol	0.6	0.9	2.4	0.6	0.6	-1.5	0.7
LDL Cholesterol	0.2	0.4	1.2	-0.1	-0.4	0.4	-1.1
Lupus	0.9	1.4	3.3	-1.0	0.7	-1.8	-0.9
Neuroticism (2016)	0.8	1.2	2.6	-0.8	-1.2	-0.1	-1.6
Primary Biliary Cirrhosis	0.8	1.1	2.4	-1.4	0.2	-0.1	-1.5
Rheumatoid Arthritis	0.9	1.3	3.6	-0.4	-0.2	-1.1	-1.9
Schizophrenia (2014)	0.5	1.0	2.3	1.5	-0.7	0.4	-1.1
Triglycerides	0.3	0.4	1.3	-0.0	-1.1	0.6	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	0.9	-0.3	-0.7	-0.3
Ulcerative Colitis	2.3	3.4	10.0	-1.2	0.2	-3.2	-1.4
Blood Eosinophil Count	1.4	10.4	17.6	2.8	-4.2	3.0	2.8
Blood Platelet Count	0.0	0.3	0.6	-0.3	0.3	-0.8	-0.6
Blood Red Count	0.0	0.3	0.5	0.7	-0.7	0.6	-0.1
Blood White Count	0.7	5.1	12.2	-3.5	-0.1	-2.1	-2.0
Heel T-Score	0.7	5.8	17.5	4.2	-0.2	-2.4	-0.3
BMI	1.9	11.1	27.7	-3.0	-0.9	-5.3	-2.6
Height	0.2	4.8	6.0	-2.5	1.9	-2.4	-1.9
Waist Hip Ratio (WHR)	0.2	1.0	3.2	-1.8	-0.0	-0.3	-0.9
Systolic Blood Pressure	0.2	0.8	2.5	-0.7	0.4	0.3	-1.6
Smoking Status	0.8	1.9	3.7	1.9	-0.6	-0.0	1.9
Allergy or Eczema	0.4	1.0	1.8	1.4	-0.7	1.2	0.5
Cardiovascular Disease	0.4	1.2	1.9	-1.3	-1.4	-1.1	-0.3
Hypothyroidism (self reported)	0.6	1.3	2.9	-1.7	-0.5	-0.8	-1.1
Respiratory disease	0.1	0.2	0.3	0.1	0.4	-0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.2	-1.1	0.2	-0.5	-1.5
Lung FEV1/FVC ratio	0.1	0.4	1.0	0.0	1.0	-0.1	-0.7
Lung FVC	0.7	3.5	7.0	2.6	1.3	1.9	1.2
Neuroticism	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.4
Chronotype (morning person)	1.0	2.3	3.8	-2.0	0.1	-1.7	-1.6
Hair Pigment	0.0	1.1	2.2	-1.4	-0.4	-0.3	-1.5
Tanning	0.1	1.7	3.3	-0.7	0.1	-1.8	-1.7
Hand grip strength (left)	0.8	2.2	5.1	2.2	-0.8	1.6	0.6
Number of treatments/medications taken	0.9	1.6	4.0	-0.5	-2.0	1.2	0.9
Average weekly spirits intake	0.4	0.5	1.0	1.0	0.1	-0.7	0.5
Sensitivity / hurt feelings	0.8	1.3	4.2	2.0	0.4	0.9	-0.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.7	0.3	-0.7	0.5	1.9
Hearing difficulty/problems: Yes	3.5	5.3	9.6	-3.1	-0.4	-2.4	-2.4
Relative age of first facial hair	0.8	1.6	5.2	1.0	-0.5	2.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	-0.1	-1.4	-0.6	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.2	-0.6	0.1	0.9
Ever had hysterectomy (womb removed)	1.9	2.1	3.6	-1.9	1.5	-1.2	-1.0
Systolic blood pressure, automated reading	0.6	1.9	4.2	-1.3	0.7	-1.1	-2.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	4.9	-1.1	0.3	-2.2	-0.6
Angina	2.0	2.7	5.1	-1.6	0.6	-2.2	-1.6
Medication for hormone replacement therapy	1.3	1.4	4.0	-0.9	0.7	2.0	0.6
Vitamin and mineral supplements	0.5	0.7	1.7	-0.2	1.3	-0.7	0.8
Supplements: Zinc	0.7	0.8	2.7	-0.3	-0.1	-1.6	-0.5
Medication: Co-codamol	0.6	0.7	1.2	-0.8	1.1	0.8	0.4
Medication: Metformin	0.8	1.1	3.0	-0.5	-1.7	1.0	0.3
Diabetes (father)	1.3	1.7	3.0	-1.0	-1.7	-1.2	1.1
Diabetes (mother)	1.1	1.5	4.0	1.2	0.3	0.5	2.0
Severe depression (siblings)	1.2	1.4	4.4	2.1	0.7	0.7	0.3
Pack years adult smoking proportion	3.5	5.3	12.7	-2.5	-0.1	-3.6	-1.5
Impedance of leg (right)	0.7	3.3	8.9	1.5	0.8	3.0	1.3
Leg fat-free mass (left)	1.6	8.5	18.1	-2.9	0.5	-4.2	-2.6
Trunk fat percentage	1.1	4.5	10.5	-1.6	0.4	-3.2	-2.2
Hand grip strength (right)	0.5	1.4	4.1	2.0	0.2	1.1	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.0	-0.5	-0.2	0.6
Current tobacco smoking	1.0	1.6	4.3	0.6	-0.9	-1.1	2.1
Average weekly fortified wine intake	0.1	0.2	0.2	-0.5	-0.5	-0.4	-0.3
Maternal smoking around birth	1.3	1.9	4.6	-1.2	-1.1	-2.2	-0.3
Fed-up feelings	0.1	0.1	0.3	0.6	0.3	-0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.2	-0.2	-0.1	1.5	1.2
Relative age voice broke	0.8	1.3	2.1	1.3	-1.1	1.4	0.5
Taking other prescription medications	1.3	2.0	4.1	-1.8	-2.0	0.7	0.4
Age when periods started (menarche)	1.0	2.4	2.9	1.7	1.6	1.6	1.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.5	-0.4	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	0.8	0.7	-0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.9	-0.3	1.0	0.8	-0.5
Qualifications: CSEs or equivalent	0.8	1.1	2.0	0.9	1.2	1.4	0.2
Serious illness, injury or assault to yourself	1.6	1.9	3.8	-2.0	-0.1	-1.9	-0.4
High blood pressure	0.8	2.1	3.0	-1.7	-0.6	-1.7	-1.6
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	0.6	-0.3	0.2	-0.2
Multivitamins +/- minerals	0.7	0.9	2.0	-0.1	-1.4	0.8	-1.0
Stomach or abdominal pain in last month	1.0	1.3	3.3	0.2	-0.1	-1.8	-1.3
Supplements: Glucosamine	0.1	0.2	0.4	-0.4	-0.6	-0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.4	-0.8	-1.1	-0.0	1.2
Medication: Atenolol	3.0	3.8	7.3	-2.5	1.4	-0.2	-2.7
Medication: Levothyroxine sodium	0.6	1.0	3.2	-1.8	0.0	-0.8	-0.2
Sitting height	0.5	3.7	7.6	-2.8	0.1	-2.2	-1.5
Chronic bronchitis/emphysema (father)	1.8	2.1	4.7	-1.7	0.6	-2.2	-0.4
High blood pressure (mother)	0.3	0.4	1.0	-0.6	-1.0	-0.5	-0.4
Body mass index (BMI)	2.2	9.3	22.5	-2.8	0.4	-4.7	-2.6
Impedance of leg (left)	1.0	4.9	11.3	2.2	0.2	3.4	1.8
Leg predicted mass (left)	1.5	7.9	17.1	-2.8	0.4	-4.1	-2.5
Trunk fat mass	1.7	7.5	16.6	-2.3	0.7	-4.1	-2.7
Waist circumference	3.2	11.8	23.4	-3.5	0.9	-4.8	-3.2
Number of incorrect matches in round	0.4	0.6	2.1	-0.5	0.1	-1.5	-0.2
Past tobacco smoking	0.1	0.2	0.6	-0.3	-0.8	-0.2	-0.4
Alcohol usually taken with meals	0.2	0.3	1.1	-0.1	1.0	0.0	-0.1
Nervous feelings	0.1	0.2	0.8	0.2	-0.0	-0.2	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.0	0.7	-0.5	1.1
Hearing difficulty/problems with background noise	1.5	2.4	4.4	-2.1	0.9	-0.8	-1.9
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-0.6	1.1	0.4	0.6
Had menopause	0.5	0.7	1.2	-0.6	1.1	-0.6	0.8
Had other major operations	1.4	1.8	6.1	-2.5	-0.2	-0.9	-0.4
Forced vital capacity (FVC)	0.3	1.0	1.4	1.2	1.2	1.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.8	2.4	0.8	-0.5	0.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.9	-0.1	0.7	1.7	0.6
Qualifications: None of the above	0.6	1.4	4.0	-2.0	0.0	-1.2	-0.3
Financial difficulties in last 2 years	0.7	1.0	1.2	-1.1	-0.7	-1.1	-1.1
Mouth/teeth dental problems	0.5	0.7	1.8	0.8	-0.0	1.3	0.6
Heart attack	0.4	0.5	1.4	0.2	-1.2	0.7	-0.0
Allergy	0.1	0.3	0.7	0.9	-0.0	0.5	0.5
Pain all over the body in last month	1.1	1.1	4.3	-0.3	-0.3	-0.2	2.1
Diabetes (self-reported)	0.9	1.3	2.5	-1.6	-1.2	-1.1	-0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	1.1	-0.4	1.2	0.1
Medication: Ramipril	0.3	0.4	1.0	1.0	-0.6	-0.0	0.3
Medication: Simvastatin	2.1	3.1	4.8	1.5	-1.0	2.1	2.2
Fluid intelligence score	0.2	0.5	1.4	-0.6	-0.5	1.2	-0.0
Illnesses of siblings	0.9	1.3	2.9	-1.7	0.3	-1.3	-0.8
Neuroticism score	0.1	0.2	0.6	0.2	-0.4	0.8	0.1
Weight	2.4	11.6	26.7	-3.1	1.1	-5.2	-3.0
Impedance of arm (right)	0.9	4.4	9.3	1.9	-0.7	3.1	2.0
Arm fat percentage (right)	1.7	6.5	13.5	-2.5	0.2	-3.7	-2.5
Trunk fat-free mass	1.3	7.6	15.6	-2.7	1.0	-4.0	-2.6
Hip circumference	1.9	8.1	22.2	-2.1	0.8	-4.7	-2.3
Time employed in main current job	0.5	0.6	0.8	0.2	-0.9	0.8	0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.2	-1.1	-0.6	-0.4	-0.6
Father’s age at death	0.9	1.1	3.3	-0.6	1.8	-0.8	-0.4
Worrier / anxious feelings	0.3	0.6	1.8	-0.3	0.6	-1.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	0.6	-0.0	1.0	0.7
Falls in the last year	0.6	0.9	1.8	-1.3	-0.8	-0.5	-1.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.2	-0.1	-0.1	-0.8
Number of live births	0.1	0.1	0.2	0.4	0.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.5	1.7	1.2	1.9	0.2
Pulse rate	1.3	2.2	4.2	-1.4	-0.4	-2.1	-1.5
Happiness	1.5	1.8	5.6	0.1	2.4	-1.2	-0.5
Noisy workplace	1.8	2.2	6.0	-1.1	-0.7	-2.4	-1.0
Qualifications: A levels/AS levels or equivalent	1.4	3.0	6.5	-0.8	1.8	-2.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-0.3	1.1	-0.6	-0.9
Mouth/teeth dental problems: Dentures	0.7	1.2	2.6	-0.7	-0.7	-1.6	-1.1
Asthma	0.4	0.8	1.4	-1.0	-0.7	-1.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.4	1.3	1.2	0.1	1.8
Medication: Cholesterol lowering	0.7	1.1	1.8	0.9	-1.3	1.3	0.1
Depression (self-reported)	0.4	0.5	1.2	0.2	-1.1	-0.7	0.5
Medication: Lansoprazole	1.0	1.2	2.0	-1.2	-0.7	0.9	-1.4
Prospective memory result	1.3	1.6	3.9	-2.0	0.0	-1.5	-0.6
Lung cancer (father)	2.6	3.0	7.6	-1.9	-0.1	-2.8	-0.9
Illnesses of mother	0.6	0.7	1.5	-1.2	-0.6	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	6.2	2.5	1.4	1.7	1.3
Pulse wave Arterial Stiffness index	0.8	0.9	1.4	-1.2	1.0	-1.2	-0.1
Impedance of arm (left)	0.8	3.9	9.3	1.6	-0.2	3.0	1.9
Arm fat mass (right)	2.2	9.1	20.4	-2.7	0.7	-4.5	-2.9
Trunk predicted mass	1.3	7.2	14.6	-2.6	1.1	-3.8	-2.5
Standing height	0.1	1.4	1.9	-0.9	1.4	-1.4	-1.1
Length of working week for main job	0.7	0.8	2.5	-0.7	-0.4	-0.4	-1.6
Exposure to tobacco smoke at home	0.6	0.6	2.1	0.4	-0.1	-1.4	-0.5
Breastfed as a baby	0.8	1.0	2.1	-0.4	-1.3	0.1	1.5
Tense / ‘highly strung’	0.1	0.2	0.5	-0.4	-0.6	-0.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.2	0.4	-0.1
Hair/balding pattern: Pattern 4	0.6	1.4	4.5	0.2	1.0	0.1	-2.1
Birth weight of first child	1.2	2.1	3.6	-0.6	1.6	-1.4	-1.9
Peak expiratory flow (PEF)	0.3	0.8	1.5	1.2	-0.0	1.2	0.5
Pulse wave reflection index	0.4	0.5	1.7	-0.0	0.6	0.0	1.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.2	-0.8	-0.3	0.4
Loud music exposure frequency	1.4	1.5	3.0	-0.6	-1.6	1.7	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.6	1.3	-0.5	0.5	0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.1	-0.9	-0.2	-1.8	-0.4
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.7	-0.1	0.3	-0.6
Medication: Paracetamol	0.7	1.1	2.7	-1.6	0.6	-1.0	-0.6
Headache pain in last month	0.2	0.4	1.2	0.4	0.1	1.1	-0.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.0	-1.3	1.3	-2.2	-0.5
Glaucoma (self-reported)	1.1	1.3	3.8	0.6	0.8	2.0	0.5
Gout (self-reported)	140.8	193.0	557.0	10.2	-3.0	23.6	10.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.4	-1.2	-1.2	-0.1	-0.0
Medication: Amlodipine	0.3	0.4	1.0	0.3	1.0	-0.6	0.2
Medication: Ventolin 100micrograms inhaler	0.7	1.0	2.7	-1.0	-0.1	-1.6	0.1
Birth weight	1.6	3.4	6.8	1.8	1.5	-1.1	-2.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.2	-0.8	0.5	-0.3
High blood pressure (siblings)	0.9	1.3	4.3	2.1	0.6	0.6	-0.0
Forced vital capacity (FVC), Best measure	0.4	1.4	2.4	1.6	1.4	0.8	0.7
Body fat percentage	1.7	6.5	13.6	-2.1	0.6	-3.7	-2.8
Leg fat percentage (right)	2.4	8.7	16.1	-2.8	0.8	-4.0	-3.2
Arm fat-free mass (right)	1.5	7.9	17.7	-2.4	1.1	-4.2	-2.6
Exposure to tobacco smoke outside home	0.4	0.6	1.2	1.1	0.1	-0.3	1.0
Comparative body size at age 10	0.1	0.4	0.8	0.4	-0.7	-0.9	0.3
Number of full brothers	0.5	0.7	1.3	-0.5	1.1	-0.2	1.1
Worry too long after embarrassment	0.4	0.6	1.9	1.4	-0.7	0.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.7	0.5	-1.2	-0.2
Wheeze or whistling in the chest in last year	1.3	2.4	8.4	-0.9	-0.6	-2.9	0.1
Number of children fathered	1.0	1.2	3.1	-0.6	-1.8	0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	4.5	0.8	2.1	-0.1	-1.6
Age at first live birth	0.6	1.1	1.8	-0.1	1.3	-1.1	-1.1
Pulse wave peak to peak time	0.8	1.0	1.7	1.2	-0.9	1.3	0.1
Health satisfaction	0.5	0.7	2.0	-0.2	-0.8	-1.4	0.0
Shortness of breath walking on level ground	1.2	1.5	4.9	0.3	-0.7	-2.2	0.7
Qualifications: College or University degree	0.1	0.3	0.9	0.4	0.9	0.2	0.1
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.5	-0.0	1.3	0.9
Mouth/teeth dental problems: Loose teeth	2.1	2.5	6.3	-0.4	1.8	-2.5	-0.6
Emphysema/chronic bronchitis	0.5	0.5	0.9	-0.9	0.4	-0.9	0.5
Medication for pain relief, constipation, heartburn	2.4	4.2	10.7	3.3	-0.1	2.4	0.6
Neck or shoulder pain in last month	3.7	5.2	7.6	-1.8	1.9	-2.7	-2.5
Medication: Blood pressure	0.7	1.3	3.3	1.0	-0.9	1.8	0.1
Angina (self-reported)	1.9	2.5	4.9	-1.5	0.7	-2.2	-1.5
Migraine (self-reported)	0.5	0.7	2.0	0.7	-0.3	1.4	0.3
Medication: Ibuprofen	1.0	1.2	2.7	0.9	0.9	-0.5	1.6
Medication: Allopurinol	130.7	174.0	529.0	9.8	-1.8	23.0	8.3
Medication: Omeprazole	0.3	0.3	0.6	-0.8	-0.4	-0.7	-0.0
Medication: Seretide 50 evohaler	0.4	0.4	0.9	-0.3	-0.8	-1.0	-0.1
Mean time to correctly identify matches	1.2	2.3	4.3	1.6	-0.2	2.1	1.5
Heart disease (mother)	0.1	0.1	0.3	-0.2	0.5	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.5	1.9	-0.6	1.1	-1.0
Whole body fat mass	2.4	9.9	21.4	-2.6	0.9	-4.6	-3.2
Leg fat mass (right)	2.9	11.4	22.5	-3.2	0.6	-4.7	-3.5
Arm predicted mass (right)	1.4	7.0	15.7	-2.3	0.8	-4.0	-2.5
Pulse rate, automated reading	1.2	3.9	6.9	-2.4	0.0	-2.6	-1.8
Alcohol intake frequency.	0.3	0.6	1.4	-1.2	-0.8	-0.1	-0.6
Comparative height size at age 10	1.0	5.4	11.3	-1.8	1.9	-3.4	-1.9
Number of full sisters	0.5	0.6	2.0	0.3	-1.4	0.4	0.4
Suffer from ‘nerves’	0.4	0.6	0.9	-0.8	-0.9	-0.2	0.8
Overall health rating	0.1	0.2	0.9	-0.1	0.1	-0.9	0.1
Chest pain or discomfort	1.7	2.4	8.6	-1.0	-0.3	-2.9	0.1
Had major operations	0.3	0.4	0.8	0.2	0.6	-0.9	0.6
Age at last live birth	1.0	1.4	3.1	1.5	1.8	0.4	-0.2
Family relationship satisfaction	1.5	1.8	5.7	2.4	1.3	-0.3	-0.0
Leg pain on walking	0.6	0.7	1.7	-1.3	-0.6	-0.9	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.8	1.2	-0.6	1.7	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	-1.3	-1.0	-0.0	-0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.9	1.1	-0.8	0.8	1.7
Medication: Aspirin	1.6	2.1	4.3	-1.5	-0.9	-2.1	-1.0
Supplements: Vitamin C	0.2	0.3	0.7	0.3	0.6	-0.9	0.2
Knee pain experienced in last month	1.4	2.1	3.6	0.4	1.8	-1.9	-1.2
Hypertension (Self-reported)	0.5	1.4	2.4	-1.6	-0.9	-0.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.7	-0.1	-1.3	0.6	0.4
Illnesses of father: Heart disease	0.5	0.7	1.7	0.9	-1.3	-0.4	-0.4
Illnesses of siblings: Diabetes	0.2	0.3	1.2	0.2	0.1	0.0	1.1
Smoking status: Previous	0.4	0.6	1.0	0.7	-0.0	0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.1	-0.1	-0.7	-0.3
Whole body fat-free mass	1.3	7.5	16.0	-2.6	0.8	-4.0	-2.5
Leg fat-free mass (right)	1.2	6.3	15.0	-2.4	0.2	-3.9	-2.2
Arm fat percentage (left)	1.9	7.6	15.5	-2.5	0.6	-3.9	-2.8
Average weekly red wine intake	0.6	0.9	3.6	0.4	1.9	-0.1	0.1
Handedness (chirality/laterality): Left-handed	2.3	2.8	3.5	-1.7	1.7	-1.9	-1.3
Mood swings	0.1	0.1	0.4	-0.0	0.6	-0.3	0.2
Loneliness, isolation	0.7	0.9	1.9	0.5	-0.2	1.4	1.2
Long-standing illness, disability or infirmity	0.6	0.9	1.6	-1.3	0.8	-0.4	-1.0
Ever had bowel cancer screening	1.7	2.0	4.3	-2.1	0.2	-1.9	0.2
Diabetes diagnosed by doctor	1.0	1.7	3.5	-1.9	-0.8	-1.0	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	5.6	-0.4	2.4	0.8	-1.2
Friendships satisfaction	1.6	2.0	4.4	0.2	2.1	-1.6	-1.0
Qualifications: nursing, teaching	2.1	3.3	6.1	2.4	-0.1	1.1	2.5
Commuting to job workplace: Walk	0.8	0.8	2.3	0.3	0.2	1.5	0.9
Eye problems/disorders: Cataract	1.5	1.8	5.0	-1.3	0.4	-2.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.9	-2.0	-0.3	-0.1	-0.8
Medication for cholesterol	0.5	0.7	2.0	0.1	1.4	-0.7	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.7	-0.7	-0.2	0.8
Back pain experienced in last month	0.4	0.7	1.9	-0.5	0.0	-0.7	-1.4
Mineral and other dietary supplements	0.2	0.3	0.5	-0.3	0.7	0.5	0.5
Breast cancer (self-reported)	2.2	2.6	7.9	-1.5	0.5	-2.8	-0.1
Asthma (self-reported)	0.3	0.6	1.1	-0.8	-0.7	-1.1	-0.5
Osteoporosis (self-reported)	1.2	1.5	3.9	2.0	0.1	1.4	0.4
Osteoarthritis (self-reported)	1.8	2.4	4.6	-1.8	0.7	-2.2	-1.1
Medication: Aspirin	0.9	1.2	3.0	-0.9	-0.4	-1.7	-0.9
Medication: Gliclazide	1.1	1.3	2.7	-1.6	-0.1	-0.1	-1.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	0.1	0.9	0.5	-0.4
Smoking status: Current	0.8	1.3	3.8	1.0	-0.1	-0.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	6.1	2.4	0.3	2.5	0.5
Whole body water mass	1.3	7.5	16.4	-2.6	0.7	-4.0	-2.5
Leg predicted mass (right)	1.1	6.1	14.6	-2.3	0.1	-3.8	-2.1
Arm fat mass (left)	2.4	9.9	22.0	-2.8	0.8	-4.7	-3.0
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	-1.6	-1.3	0.6	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.8	-0.8	0.7	0.0
Miserableness	0.5	0.9	3.2	0.1	0.1	1.8	0.7
Guilty feelings	0.6	0.9	1.1	1.0	-0.9	1.1	0.7
Wears glasses or contact lenses	2.0	2.3	4.4	-2.1	1.4	-1.7	-0.1
Ever taken oral contraceptive pill	1.6	1.7	3.6	-1.5	-0.0	-1.0	-1.9
Hearing aid user	1.4	1.6	3.8	1.0	-1.2	2.0	-0.1
Mother’s age at death	3.0	3.7	5.1	1.9	-1.1	2.3	2.2
Financial situation satisfaction	0.2	0.3	0.5	0.2	0.7	-0.2	-0.7
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.3	-1.2	0.1	0.5	-1.5
Commuting to job workplace: Public transport	2.0	2.4	4.6	-0.9	1.4	-2.1	-1.6
Eye problems/disorders: Glaucoma	0.9	1.1	2.7	1.2	-0.0	1.7	0.4
Medication: Blood pressure	0.6	1.1	1.7	-0.9	-0.5	-1.3	-1.3
Pain type(s) experienced in last month: Hip pain	3.8	4.8	6.5	-2.2	1.1	-2.5	-2.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.2	-0.2	-0.2	-1.8	-1.6
High cholesterol (Self-reported)	3.0	5.3	11.1	2.0	-1.7	3.3	1.8
Medication: Bendroflumethiazide	1.3	2.0	4.3	-1.5	-0.5	-2.1	-1.1
Medication: Paracetamol	0.3	0.5	1.4	-1.2	-0.1	-0.6	-0.6
Medication: Lisinopril	0.5	0.6	1.4	-0.7	-0.5	0.5	-1.2
Medication: Atorvastatin	0.5	0.7	1.6	0.0	-1.3	0.4	-1.0
Illnesses of father: High blood pressure	0.2	0.3	1.0	0.2	0.2	0.3	-1.0
Alcohol drinker status: Never	0.8	1.0	2.2	0.2	-1.3	1.5	0.4
Ever smoked	0.2	0.4	0.8	0.5	0.5	-0.4	0.9
Basal metabolic rate	1.6	9.0	20.1	-2.8	0.9	-4.5	-2.7
Leg fat percentage (left)	2.1	7.7	15.6	-2.4	0.6	-4.0	-3.0
Arm fat-free mass (left)	1.3	6.5	14.3	-2.4	0.7	-3.8	-2.3
Number of operations (self-reported)	1.6	2.4	4.9	-2.2	-0.0	-2.1	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.4	0.5	0.7	0.0	0.2
Irritability	0.0	0.1	0.1	-0.4	0.1	-0.0	0.4
Risk taking	1.5	2.1	4.2	0.1	-1.3	2.0	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.4	-1.5	-0.8	-1.1	-0.7
Fractured/broken bones in last 5 years	1.3	1.6	4.5	-2.1	0.4	-0.5	-1.2
Age started oral contraceptive pill	0.7	0.9	2.6	-0.8	-0.4	-0.3	-1.6
Diastolic blood pressure, automated reading	0.3	1.0	2.0	-0.1	1.0	-0.9	-1.4
Ever depressed for a whole week	0.6	0.7	1.5	-0.4	0.1	1.2	1.1
Unable to work because of sickness or disability	1.1	1.4	4.0	-1.1	-0.6	-2.0	-0.4
Commuting to job workplace: Cycle	2.1	2.5	5.1	2.1	0.0	0.9	2.3
Myopia	0.4	0.5	1.2	-1.1	0.4	-0.5	-0.7
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.5	1.9	1.1	1.3	1.1
Cholesterol lowering medication	1.9	2.8	6.5	1.0	-1.3	2.5	1.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.5	-0.8	-0.4	-0.3
Pain experienced in last month	1.4	2.3	3.8	0.2	-1.9	1.9	1.4
Supplements: Calcium	0.3	0.3	0.5	0.5	-0.7	0.7	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.9	0.0	-0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.5	-1.2	0.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	-0.3	-0.3	0.7	-0.1
Heart disease (siblings)	1.4	1.7	4.0	-1.0	-2.0	0.9	0.9
Alcohol drinker status: Previous	1.3	1.5	3.7	-1.9	0.3	-1.0	-1.0
Pack years of smoking	3.4	4.9	11.0	-2.5	-0.4	-3.3	-1.5
Impedance of whole body	1.1	5.7	13.7	2.3	0.0	3.7	2.0
Leg fat mass (left)	2.8	11.1	22.8	-3.0	0.6	-4.8	-3.5
Arm predicted mass (left)	1.6	8.2	18.3	-2.5	1.0	-4.3	-2.7