Hub : Genes

SPP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.2530	0.0650	2.7e-05	0.088	NA	0.098	NA	0.093	8.9e-05	NA	3.6e-05	NA	5.9e-05
2	GTEx	Nerve Tibial	0.1493	0.0575	1.8e-03	0.083	NA	0.069	NA	0.081	1.7e-06	NA	1.3e-05	NA	2.4e-06
3	NTR	Blood	0.1854	0.0265	0.0e+00	0.079	0.151	0.172	0.175	0.181	3.1e-24	3.4e-46	4.8e-53	4.1e-54	6.2e-56
4	TCGA	Breast Invasive Carcinoma	0.0366	0.0180	5.1e-04	0.002	0.010	0.010	NA	0.004	1.4e-01	3.5e-03	3.3e-03	NA	4.2e-02
5	TCGA	Pancreatic Adenocarcinoma	0.1430	0.0660	2.2e-03	0.026	0.065	0.024	NA	0.013	3.0e-02	1.0e-03	3.3e-02	NA	8.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.6	-0.4	-0.2	-1.3	0.8	0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.4	-0.5	-0.5	-0.0	-0.6
Depressed Affect (Nagel 2018)	0.7	1.4	2.2	1.2	1.2	1.5	-0.3	1.4
Depression (Nagel 2018)	0.5	0.7	1.1	1.0	-0.3	1.1	-1.0	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.6	2.1	0.3	1.8	-0.5	0.0
Neuroticism (Nagel 2018)	0.5	1.1	2.7	1.6	0.7	1.1	-0.7	0.8
Schizophrenia (2018)	0.2	0.5	0.7	0.8	-0.5	0.4	-0.7	-0.8
Schizophrenia vs Biploar Disorder	0.8	1.0	2.9	0.2	-1.4	-0.1	-0.2	-1.7
Worry (Nagel 2018)	0.5	1.1	2.8	1.1	1.1	0.8	-0.1	1.7
Alzheimer’s Disease (in mother)	1.8	2.1	7.6	1.2	1.1	-0.2	0.0	2.8
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.4	0.6	-0.3	0.6	-0.3
Alzheimer’s Disease (including proxy)	1.1	1.6	3.2	1.2	1.5	-0.9	0.5	1.8
Crohns Disease (2017)	0.9	2.0	4.7	-2.2	-1.1	1.3	-1.1	-1.1
Irritable Bowel Disease (IBD)	1.4	3.4	10.8	-3.3	-1.5	1.6	-0.3	-1.2
Ulcerative Colitis (UC)	1.3	2.4	9.4	-3.1	-0.8	1.3	0.5	-0.3
Major Depression (MDD)	0.7	0.9	2.0	0.3	1.1	1.4	-1.0	-0.1
Reaction Time	0.3	0.5	0.9	0.8	0.6	-0.9	-0.9	-0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.7	1.6	0.6	0.1	0.2	0.0
Breast Cancer	0.6	1.5	3.1	-0.2	-0.8	1.3	-1.8	1.4
Ovarian Cancer	0.4	0.5	1.5	-0.1	-1.2	0.3	-0.9	0.5
Prostate Cancer	1.6	2.3	5.4	-0.5	-1.1	2.3	-1.2	-1.8
Age at First Birth	1.2	1.8	2.8	1.2	-0.3	1.7	-1.5	-1.5
Bipolar Disorder (2011)	1.0	1.0	2.7	-0.4	-1.1	-0.4	-0.7	-1.7
Body Mass Index (BMI) (2010)	0.8	1.0	2.8	-1.0	-1.7	-0.8	-0.5	-0.9
Coronary Artery Disease (CAD)	2.7	3.3	9.8	-0.9	-1.1	3.1	-1.7	-1.2
Crohns Disease (2012)	0.7	1.1	2.2	-1.2	0.8	-0.5	1.0	-1.5
Mean Putamen Volume	1.3	1.4	3.9	1.0	2.0	-0.6	1.1	0.8
Fasting Glucose	0.6	0.7	1.3	-1.2	-1.1	-0.7	-0.6	0.5
HbA1C	0.0	0.0	0.1	-0.2	-0.0	0.2	0.2	0.1
HDL Cholesterol	0.5	0.8	2.1	0.6	0.7	-0.9	1.4	0.2
LDL Cholesterol	0.3	0.5	1.2	-0.6	0.6	0.2	1.1	0.6
Lupus	1.1	1.7	3.3	1.3	-1.6	0.8	-1.8	-0.1
Neuroticism (2016)	0.4	0.6	1.2	0.7	1.1	1.0	0.4	0.4
Primary Biliary Cirrhosis	1.7	2.5	3.0	-1.1	1.6	-1.7	1.5	1.7
Rheumatoid Arthritis	0.1	0.1	0.3	-0.5	0.2	-0.2	0.5	0.3
Schizophrenia (2014)	0.3	0.6	1.3	1.0	-0.4	-0.3	0.5	-1.2
Triglycerides	0.3	0.4	1.2	-0.4	0.0	1.1	-0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.7	-1.3	-0.6	0.1	-0.0	0.0
Ulcerative Colitis	1.2	1.8	5.4	-2.3	-0.2	-0.1	1.7	-0.9
Blood Eosinophil Count	0.4	2.8	6.0	-0.7	-2.4	1.3	-1.5	-1.9
Blood Platelet Count	0.2	1.9	3.6	-1.4	0.8	-1.9	1.2	-1.4
Blood Red Count	0.1	1.2	2.3	0.9	-0.9	1.5	-0.9	1.1
Blood White Count	0.4	2.8	5.6	-0.4	1.6	-2.4	2.3	0.7
Heel T-Score	15.7	124.7	259.2	9.2	16.1	-5.7	13.0	8.8
BMI	0.9	5.1	10.8	-2.3	-2.8	1.0	-0.5	-3.3
Height	1.2	23.0	38.1	-0.8	6.1	-1.1	6.2	6.1
Waist Hip Ratio (WHR)	0.5	2.0	4.4	2.0	2.1	-0.3	-0.3	1.3
Systolic Blood Pressure	0.4	1.9	4.5	2.1	1.5	-0.7	0.6	1.3
Smoking Status	0.3	0.7	1.9	-0.4	1.4	-0.8	0.8	0.5
Allergy or Eczema	0.6	1.6	5.5	0.7	-1.0	0.1	-0.9	-2.4
Cardiovascular Disease	0.4	1.4	4.2	0.9	2.0	-0.7	0.9	0.9
Hypothyroidism (self reported)	1.6	3.6	5.3	-0.9	-2.3	2.3	-2.2	-1.3
Respiratory disease	0.1	0.3	0.7	-0.8	0.8	-0.0	0.6	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-0.8	-0.6	-0.2	0.1	-1.0
Lung FEV1/FVC ratio	0.1	0.7	2.5	-1.6	0.3	0.3	-0.4	-0.8
Lung FVC	0.2	0.9	3.2	-0.5	0.8	-1.8	0.7	-0.3
Neuroticism	0.3	0.8	2.3	0.8	0.5	1.5	-0.4	1.0
Chronotype (morning person)	1.1	2.5	5.8	0.4	1.7	-1.7	2.4	0.8
Hair Pigment	0.1	3.0	9.7	0.3	3.1	-1.9	1.2	0.1
Tanning	0.0	0.5	0.8	0.6	0.8	-0.7	0.9	-0.1
Hand grip strength (left)	1.9	5.1	16.1	-1.0	-2.0	4.0	-1.5	-1.5
Number of treatments/medications taken	0.4	0.7	1.4	-0.4	0.8	0.9	-0.7	1.2
Average weekly spirits intake	0.4	0.4	1.6	0.5	0.0	-0.0	0.6	1.3
Sensitivity / hurt feelings	0.7	1.2	2.1	0.2	-1.4	0.9	-1.4	-1.0
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.4	1.5	0.5	-0.0	-0.7	1.2
Hearing difficulty/problems: Yes	0.7	1.1	3.4	-0.8	-1.2	-1.8	-0.4	-0.3
Relative age of first facial hair	0.2	0.5	0.8	-0.5	0.3	0.9	-0.9	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	-0.5	-0.8	1.1	-1.2	-1.0
Ever used hormone-replacement therapy (HRT)	3.3	4.2	7.0	-1.4	-2.7	2.0	-1.9	-2.2
Ever had hysterectomy (womb removed)	1.3	1.5	3.1	-0.5	1.1	-0.1	1.6	1.8
Systolic blood pressure, automated reading	0.2	0.7	1.9	1.2	-0.1	1.4	0.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.2	-1.1	-0.8	0.3	-0.6	-0.7
Angina	0.4	0.5	1.9	0.6	-0.1	-0.7	1.4	0.2
Medication for hormone replacement therapy	0.8	0.9	2.6	-0.8	-0.6	0.8	-1.6	-0.2
Vitamin and mineral supplements	0.1	0.1	0.3	-0.4	-0.4	-0.1	0.5	-0.1
Supplements: Zinc	0.5	0.6	1.3	1.1	-0.8	0.7	0.1	-0.5
Medication: Co-codamol	1.2	1.4	4.0	-1.0	-0.9	1.2	-2.0	-0.1
Medication: Metformin	0.6	0.8	1.8	-0.3	-1.1	1.4	-1.0	-0.2
Diabetes (father)	0.6	0.8	1.7	-0.4	-0.7	-1.3	1.2	-0.2
Diabetes (mother)	0.4	0.5	1.8	1.3	0.0	0.7	0.1	0.1
Severe depression (siblings)	1.2	1.4	3.2	1.8	1.4	0.4	0.9	0.8
Pack years adult smoking proportion	0.6	1.0	2.7	-0.3	1.1	-0.8	1.7	-0.4
Impedance of leg (right)	1.7	8.4	19.6	2.4	3.0	-2.6	0.6	4.4
Leg fat-free mass (left)	0.4	2.3	3.7	-1.9	-1.1	1.9	1.1	-1.5
Trunk fat percentage	0.1	0.6	1.1	-0.9	-1.1	0.1	0.8	-0.5
Hand grip strength (right)	1.5	4.2	6.8	-1.4	-2.3	2.6	-1.2	-2.3
Townsend deprivation index at recruitment	2.2	3.0	4.9	-0.8	2.2	-1.4	2.2	1.6
Current tobacco smoking	0.6	1.0	2.0	-1.0	1.1	-1.4	0.7	0.3
Average weekly fortified wine intake	0.4	0.4	1.3	-0.3	-0.7	0.2	0.5	1.1
Maternal smoking around birth	0.5	0.7	2.5	-0.4	-1.6	0.5	-0.6	-0.2
Fed-up feelings	0.5	0.9	2.2	0.7	0.9	0.1	1.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	1.0	-0.0	0.1	-1.2	1.0
Relative age voice broke	0.2	0.4	0.8	-0.4	0.6	0.7	0.1	-0.9
Taking other prescription medications	0.9	1.3	3.0	-1.7	-0.8	0.1	-1.7	0.5
Age when periods started (menarche)	1.9	4.6	10.1	-1.4	-3.2	1.2	-3.0	-1.0
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	11.8	-0.5	-0.3	3.4	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	11.3	25.5	57.2	3.0	7.6	-4.1	5.2	4.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	-0.3	-1.7	0.7	-1.7	-0.4
Qualifications: CSEs or equivalent	1.0	1.4	5.3	0.3	-0.7	0.9	-2.3	-0.3
Serious illness, injury or assault to yourself	0.2	0.3	1.3	-0.3	-0.3	1.1	-0.2	0.2
High blood pressure	0.0	0.1	0.3	0.6	0.5	-0.2	0.0	-0.1
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.3	0.1	-1.9	0.2	-1.4	-2.5
Multivitamins +/- minerals	0.4	0.5	0.8	0.9	0.4	-0.1	-0.8	0.9
Stomach or abdominal pain in last month	0.4	0.5	1.5	-1.2	-0.1	-0.6	0.3	-0.6
Supplements: Glucosamine	1.1	1.4	5.5	0.6	1.0	0.3	2.4	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.5	-0.9	-0.1	-0.5	-0.7
Medication: Atenolol	1.4	1.7	5.0	-1.1	1.2	-1.0	-0.1	2.2
Medication: Levothyroxine sodium	0.8	1.3	1.7	-1.3	-1.3	1.3	-1.3	0.1
Sitting height	1.1	7.5	14.2	-3.7	2.1	1.0	3.8	2.0
Chronic bronchitis/emphysema (father)	0.9	1.1	1.9	1.4	1.2	-0.9	1.1	0.2
High blood pressure (mother)	0.6	0.9	3.0	1.7	1.0	-0.1	-0.2	0.7
Body mass index (BMI)	1.2	5.0	9.1	-2.3	-3.0	1.3	-0.6	-3.0
Impedance of leg (left)	2.2	10.6	28.0	2.6	3.6	-2.1	0.5	5.3
Leg predicted mass (left)	0.4	2.3	4.0	-1.8	-1.1	2.0	1.0	-1.4
Trunk fat mass	0.2	0.8	1.6	-1.3	-1.0	0.7	0.9	-0.5
Waist circumference	0.5	1.6	3.1	-1.7	-1.2	1.7	0.4	-0.9
Number of incorrect matches in round	0.4	0.7	2.4	-0.4	0.8	-0.7	1.5	-0.3
Past tobacco smoking	0.1	0.3	0.8	0.1	0.1	0.9	0.6	0.3
Alcohol usually taken with meals	1.2	1.9	4.2	-1.9	-2.0	-0.3	-0.5	-1.2
Nervous feelings	0.5	0.9	3.2	1.8	0.6	-0.1	-0.0	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.5	-0.1	-0.3	0.4	-1.2	1.2
Hearing difficulty/problems with background noise	0.7	1.2	2.7	0.8	-0.4	-1.6	-0.7	1.3
Hair/balding pattern: Pattern 2	0.9	1.2	3.7	0.2	1.4	-0.2	0.1	1.9
Had menopause	0.5	0.6	1.9	-0.4	-1.4	0.5	-0.9	-0.2
Had other major operations	0.5	0.6	1.5	-0.3	1.2	-0.3	0.9	-0.6
Forced vital capacity (FVC)	1.3	4.9	10.8	-0.2	3.3	-2.0	2.3	2.2
Heel bone mineral density (BMD) T-score, automated (right)	9.5	21.8	50.0	3.0	7.1	-3.5	4.9	3.7
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.6	0.2	0.7	1.5	-1.4	1.6
Qualifications: None of the above	2.0	4.2	11.6	-1.0	1.4	-3.4	1.0	2.3
Financial difficulties in last 2 years	0.2	0.2	0.6	-0.0	-0.3	0.7	-0.8	0.2
Mouth/teeth dental problems	1.0	1.5	4.1	0.5	-1.5	0.6	-2.0	-0.9
Heart attack	0.1	0.1	0.3	0.2	0.4	-0.6	0.2	-0.1
Allergy	0.6	1.4	2.1	0.8	1.5	0.8	1.1	1.4
Pain all over the body in last month	0.4	0.5	1.8	-0.3	0.5	-1.3	-0.1	-0.5
Diabetes (self-reported)	0.3	0.5	1.1	-0.4	-0.8	0.4	-0.6	-1.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.5	-1.1	-1.1	-0.9	0.1	-2.4
Medication: Ramipril	1.7	2.2	6.2	2.5	1.7	-0.3	0.3	1.2
Medication: Simvastatin	0.4	0.6	1.3	1.2	0.4	1.0	-0.4	0.6
Fluid intelligence score	1.0	2.0	5.3	2.3	1.7	-0.0	0.2	1.3
Illnesses of siblings	0.6	0.8	2.2	-1.1	-0.5	0.2	0.6	-1.5
Neuroticism score	0.5	1.1	2.0	1.1	0.1	1.4	-1.1	1.0
Weight	0.4	2.0	4.7	-2.2	-1.0	1.4	1.1	-0.9
Impedance of arm (right)	1.7	7.8	10.4	2.6	3.2	-2.7	2.6	2.8
Arm fat percentage (right)	0.5	2.1	4.6	-1.5	-1.9	-0.3	0.6	-2.2
Trunk fat-free mass	0.3	1.8	4.3	-1.7	0.0	2.1	1.4	0.1
Hip circumference	0.7	2.9	7.5	-2.7	-1.0	1.6	1.7	-0.7
Time employed in main current job	0.7	0.8	3.0	-0.7	-1.7	0.4	-0.0	-0.4
Alcohol intake versus 10 years previously	0.6	0.9	2.6	-0.4	0.9	-0.4	-0.7	1.6
Father’s age at death	1.1	1.5	3.2	-1.0	1.0	-1.3	1.8	0.8
Worrier / anxious feelings	0.1	0.2	0.5	0.5	0.7	0.5	-0.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	-0.3	-0.1	0.8	-1.0	-1.4
Falls in the last year	0.2	0.2	0.4	-0.6	0.2	0.5	-0.6	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	0.2	0.5	-1.2	1.1	-0.7
Number of live births	1.0	1.4	3.6	0.7	1.9	-1.4	0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	8.4	-0.8	2.9	-1.3	1.6	1.3
Pulse rate	0.5	0.8	1.7	-0.3	-1.1	1.3	0.1	-1.0
Happiness	0.2	0.2	0.9	-0.2	0.3	-0.2	-0.2	1.0
Noisy workplace	1.2	1.5	4.4	-0.6	-2.1	0.4	-0.5	-1.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	1.2	1.0	-0.7	1.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	0.1	-0.4	-0.3	-1.0	-0.4
Mouth/teeth dental problems: Dentures	2.5	4.2	10.8	-1.5	2.2	-0.8	3.3	1.6
Asthma	0.2	0.4	0.8	-0.3	0.6	-0.8	0.9	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.2	0.1	-0.1	0.4	-1.1	-0.6
Medication: Cholesterol lowering	0.2	0.3	1.0	0.3	-0.6	0.1	-1.0	-0.2
Depression (self-reported)	0.8	1.0	3.6	0.2	0.8	0.8	-0.0	1.9
Medication: Lansoprazole	0.8	0.9	4.5	-2.1	-0.3	0.2	0.2	0.2
Prospective memory result	1.5	1.8	5.7	0.2	1.2	-2.4	1.3	-0.1
Lung cancer (father)	0.4	0.4	1.1	0.8	0.4	0.4	1.1	-0.3
Illnesses of mother	1.3	1.7	4.0	-2.0	-1.1	0.8	-0.1	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	5.2	0.2	2.3	-1.0	0.7	1.2
Pulse wave Arterial Stiffness index	0.8	0.9	1.7	0.9	0.4	-1.3	0.3	1.3
Impedance of arm (left)	1.2	5.5	7.2	2.0	2.6	-2.6	1.6	2.7
Arm fat mass (right)	0.5	2.0	3.5	-1.9	-1.6	0.6	0.5	-1.8
Trunk predicted mass	0.3	1.8	4.4	-1.6	-0.0	2.1	1.3	0.1
Standing height	0.9	9.1	17.0	-0.2	3.9	0.2	3.6	4.1
Length of working week for main job	0.3	0.4	1.3	0.2	-0.2	-0.1	-0.7	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.5	0.0	0.6	-0.9	0.4	1.2
Breastfed as a baby	0.4	0.4	2.2	1.5	-0.1	0.1	-0.0	-0.2
Tense / ‘highly strung’	1.9	3.1	6.7	2.6	1.6	-0.7	-0.2	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-1.0	-0.2	1.3	-1.0	-0.8
Hair/balding pattern: Pattern 4	0.8	2.0	3.1	0.9	1.8	-1.4	1.5	1.3
Birth weight of first child	0.2	0.4	1.1	-0.3	0.5	0.3	0.8	1.1
Peak expiratory flow (PEF)	0.9	2.0	6.3	-0.1	2.5	-0.4	1.8	0.8
Pulse wave reflection index	1.2	1.4	5.4	0.9	0.1	-2.3	0.2	0.9
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.6	1.0	-0.1	1.3	-1.1	1.2
Loud music exposure frequency	0.9	0.9	3.2	-1.8	-1.1	0.5	0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	8.1	0.3	-1.2	2.8	-0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.6	1.6	-0.7	0.6	-0.8	-0.0
Blood clot in the leg (DVT)	0.3	0.4	1.0	1.0	-0.1	0.7	-0.6	0.4
Medication: Paracetamol	0.6	1.0	4.4	-2.1	-0.3	0.1	-0.4	0.3
Headache pain in last month	1.4	2.4	6.5	0.8	-1.8	1.2	-2.5	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	-0.3	0.2	-0.1	1.1	0.4
Glaucoma (self-reported)	0.3	0.3	0.9	0.6	-0.0	-0.3	-0.5	0.9
Gout (self-reported)	21.4	29.4	93.1	0.8	-1.1	3.8	-9.7	6.2
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	6.6	-1.2	-2.3	2.3	-2.6	-0.6
Medication: Amlodipine	0.9	1.3	2.5	-0.5	1.6	-0.3	1.0	1.6
Medication: Ventolin 100micrograms inhaler	0.9	1.2	4.0	0.1	1.2	-2.0	0.7	-0.5
Birth weight	0.4	0.9	3.9	0.2	0.5	-0.4	2.0	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.3	0.4
High blood pressure (siblings)	1.6	2.4	4.7	2.1	2.2	0.3	0.8	1.3
Forced vital capacity (FVC), Best measure	1.0	3.7	8.9	0.7	3.0	-1.6	1.6	2.0
Body fat percentage	0.2	1.0	2.2	-1.1	-1.5	0.2	0.5	-1.0
Leg fat percentage (right)	0.3	1.0	2.2	-1.2	-1.5	-0.2	0.1	-1.1
Arm fat-free mass (right)	0.5	2.5	7.2	-2.0	-1.0	2.7	0.4	-0.6
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.2	0.6	0.4	0.3	0.2
Comparative body size at age 10	0.4	1.2	3.3	-0.3	-1.6	0.2	0.1	-1.8
Number of full brothers	0.6	0.7	1.9	-0.5	0.8	-0.8	0.1	1.4
Worry too long after embarrassment	0.8	1.3	2.9	1.6	-0.5	1.7	-0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.7	-0.3	0.4	-1.0	-0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	0.1	1.2	-0.6	0.6	1.0
Number of children fathered	0.8	1.0	2.4	-0.2	-1.3	0.0	-0.8	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.5	0.6	-1.3	0.7	-0.9	-1.6
Age at first live birth	0.3	0.5	1.3	0.6	-0.7	-0.4	0.5	-1.2
Pulse wave peak to peak time	0.5	0.6	1.6	-0.8	0.1	1.3	-0.0	-0.8
Health satisfaction	0.3	0.4	1.1	-1.1	-0.2	-0.0	0.5	-0.8
Shortness of breath walking on level ground	1.6	2.0	5.5	-0.9	-1.9	-0.2	-0.2	-2.3
Qualifications: College or University degree	0.3	0.9	3.1	1.7	0.3	0.1	0.7	-0.9
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.5	-0.1	-0.6	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.1	-0.4	1.3	-1.4	1.8	0.6
Emphysema/chronic bronchitis	1.5	1.7	5.2	0.4	-0.5	-2.3	-1.6	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.9	0.2	1.2	0.5	0.3
Neck or shoulder pain in last month	1.6	2.3	5.6	-0.5	2.4	-1.2	1.6	1.4
Medication: Blood pressure	0.1	0.2	0.6	-0.1	0.1	0.3	-0.5	-0.8
Angina (self-reported)	0.5	0.6	1.7	0.9	-0.1	-0.8	1.3	0.2
Migraine (self-reported)	0.8	1.0	1.8	1.4	-0.2	0.8	-0.8	1.3
Medication: Ibuprofen	0.3	0.3	1.2	0.0	-0.2	0.5	-1.1	-0.2
Medication: Allopurinol	16.5	22.0	69.6	1.4	-0.8	2.6	-8.3	5.6
Medication: Omeprazole	0.6	0.7	2.0	-0.8	-0.4	-0.4	-0.8	-1.4
Medication: Seretide 50 evohaler	0.6	0.6	1.2	-0.6	1.1	-0.1	0.8	-1.0
Mean time to correctly identify matches	0.2	0.4	1.0	0.6	-0.1	-0.2	-1.0	-0.6
Heart disease (mother)	1.4	1.7	3.8	1.9	1.2	-0.9	1.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.2	1.4	0.9	0.8	0.3
Whole body fat mass	0.3	1.0	2.3	-1.5	-1.0	0.5	1.0	-0.9
Leg fat mass (right)	0.4	1.5	2.9	-1.6	-1.7	0.6	0.2	-1.3
Arm predicted mass (right)	0.5	2.3	6.4	-2.0	-0.7	2.5	0.6	-0.4
Pulse rate, automated reading	0.5	1.5	2.7	-1.7	-0.9	1.2	0.3	-1.6
Alcohol intake frequency.	1.1	2.5	6.3	-1.5	-1.5	1.0	-2.5	-0.8
Comparative height size at age 10	0.8	4.4	9.5	0.3	2.1	0.4	2.8	3.1
Number of full sisters	0.6	0.7	2.8	0.4	-0.6	0.2	-1.7	0.3
Suffer from ‘nerves’	0.2	0.4	0.8	0.3	0.2	0.8	-0.4	0.9
Overall health rating	0.0	0.1	0.2	-0.5	0.5	0.3	-0.1	-0.0
Chest pain or discomfort	0.8	1.1	2.0	-1.0	1.2	-1.0	1.4	0.3
Had major operations	0.6	0.7	2.9	0.7	-0.3	0.5	0.1	1.7
Age at last live birth	0.6	0.8	1.4	1.0	0.9	-1.2	0.9	-0.2
Family relationship satisfaction	1.8	2.2	6.8	1.0	-0.8	2.6	-1.6	0.4
Leg pain on walking	1.2	1.6	2.4	-1.6	0.9	-1.0	1.5	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.6	-1.0	-2.1	1.1	-1.3	-0.8
Commuting to job workplace: Car/motor vehicle	2.6	3.0	7.0	-1.7	-2.7	-0.5	-0.9	-2.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.6	1.6	0.5	0.0	1.1	0.9
Medication: Aspirin	0.6	0.8	1.8	1.3	0.3	-0.5	1.4	0.1
Supplements: Vitamin C	1.2	1.4	4.0	-0.3	-0.4	2.0	-1.1	-1.2
Knee pain experienced in last month	1.8	2.9	6.3	-2.0	-0.1	-0.2	1.9	-2.5
Hypertension (Self-reported)	0.0	0.1	0.4	0.6	0.4	-0.1	-0.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.0	-1.2	-0.7	1.4	-1.1	-0.7
Illnesses of father: Heart disease	1.2	1.6	4.1	1.1	2.0	0.0	1.7	0.0
Illnesses of siblings: Diabetes	1.4	1.7	4.0	-0.0	0.7	-2.0	0.7	2.0
Smoking status: Previous	0.3	0.5	0.9	0.3	-0.6	0.2	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.8	1.0	1.0	-0.0	1.4	0.6
Whole body fat-free mass	0.3	1.9	4.9	-1.7	-0.4	2.2	1.2	-0.5
Leg fat-free mass (right)	0.4	2.2	4.6	-1.8	-0.9	2.1	1.0	-1.1
Arm fat percentage (left)	0.6	2.2	4.5	-1.6	-1.9	-0.2	0.4	-2.1
Average weekly red wine intake	0.5	0.7	1.8	1.2	0.6	0.3	1.3	-0.0
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.8	-0.5	1.2	-1.2	1.4	1.1
Mood swings	0.6	1.1	2.9	0.3	-1.3	1.7	-0.9	-0.2
Loneliness, isolation	0.7	1.0	1.8	1.2	0.6	0.8	-0.9	1.4
Long-standing illness, disability or infirmity	0.2	0.2	0.9	-0.0	0.9	0.3	0.1	0.4
Ever had bowel cancer screening	0.3	0.3	1.0	-0.5	0.4	-0.0	-0.4	-1.0
Diabetes diagnosed by doctor	0.2	0.3	0.7	-0.6	-0.4	-0.0	0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.6	-1.3	-1.2	0.2	-1.9	-0.1
Friendships satisfaction	2.0	2.5	6.2	2.5	1.5	-0.7	0.5	1.8
Qualifications: nursing, teaching	0.9	1.4	2.5	-0.4	-1.6	1.5	-0.9	-1.1
Commuting to job workplace: Walk	0.4	0.5	1.4	1.2	-0.1	0.3	-0.5	0.7
Eye problems/disorders: Cataract	1.1	1.3	2.9	1.3	1.7	-1.0	0.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.0	-1.1	0.3	-0.9	0.8	-1.4
Medication for cholesterol	0.5	0.7	1.4	-0.6	-1.2	-1.1	0.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.1	1.2	-1.2	0.8	-1.4	1.3
Back pain experienced in last month	0.9	1.4	3.3	-1.8	-0.0	1.8	0.1	-0.5
Mineral and other dietary supplements	0.6	0.8	2.3	-1.5	-0.2	-0.5	-0.9	-0.7
Breast cancer (self-reported)	2.1	2.5	5.7	1.1	0.6	-0.2	2.4	-2.3
Asthma (self-reported)	0.1	0.2	0.3	-0.4	0.4	-0.5	0.5	-0.1
Osteoporosis (self-reported)	18.4	22.8	37.1	-0.9	-5.8	4.9	-6.1	-4.4
Osteoarthritis (self-reported)	2.6	3.4	6.9	-0.4	2.6	-2.3	2.2	0.5
Medication: Aspirin	1.0	1.3	2.8	1.7	0.8	0.1	1.5	0.9
Medication: Gliclazide	1.4	1.6	3.1	-1.8	-1.3	1.7	-0.7	-0.1
Illnesses of father: None of the above (group 1)	1.1	1.4	2.7	0.6	-1.2	1.6	-1.4	-0.6
Smoking status: Current	0.5	0.8	2.1	-1.1	0.8	-1.5	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.0	0.4	1.7	-1.2	0.9	0.4
Whole body water mass	0.4	2.0	4.9	-1.8	-0.5	2.2	1.2	-0.6
Leg predicted mass (right)	0.4	2.2	5.0	-1.8	-0.9	2.2	1.0	-1.1
Arm fat mass (left)	0.5	1.9	4.0	-2.0	-1.4	0.3	0.8	-1.7
Number of self-reported non-cancer illnesses	0.3	0.6	2.0	-1.4	0.4	0.1	-0.9	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.8	-0.3	-0.9	0.4	-0.5	-0.3
Miserableness	0.4	0.7	1.7	1.3	0.1	0.3	-1.2	0.2
Guilty feelings	0.8	1.2	3.3	0.3	-0.8	1.2	-1.8	-0.5
Wears glasses or contact lenses	0.5	0.6	1.2	-1.0	-0.1	-0.6	1.1	-0.6
Ever taken oral contraceptive pill	0.6	0.7	3.3	0.2	-0.5	0.1	0.0	-1.8
Hearing aid user	0.1	0.1	0.3	0.2	-0.4	-0.3	-0.6	-0.3
Mother’s age at death	1.0	1.2	2.2	1.4	1.5	0.2	0.1	1.3
Financial situation satisfaction	0.2	0.3	0.8	0.3	0.5	-0.1	0.6	0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.3	0.7	0.1	0.6	0.3
Commuting to job workplace: Public transport	1.3	1.5	2.7	0.2	1.6	-1.5	1.6	0.4
Eye problems/disorders: Glaucoma	1.3	1.5	2.6	1.4	-1.2	-0.2	-1.6	-1.1
Medication: Blood pressure	0.8	1.6	3.8	1.9	1.7	0.5	0.2	1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	1.0	0.4	1.4	0.4	-0.7
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.6	1.9	1.7	-1.2	1.8	1.1
High cholesterol (Self-reported)	1.1	2.0	2.3	1.4	1.0	1.5	-1.5	1.5
Medication: Bendroflumethiazide	0.4	0.6	1.7	-0.8	-0.6	1.3	0.2	-0.4
Medication: Paracetamol	0.7	1.1	2.7	-1.7	-1.2	0.8	-0.7	-0.4
Medication: Lisinopril	1.1	1.5	3.9	0.7	-0.4	1.3	-1.0	-2.0
Medication: Atorvastatin	0.4	0.5	1.5	-0.4	0.3	1.2	-0.7	-0.0
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.4	0.6	0.1	0.3	0.6
Alcohol drinker status: Never	0.4	0.5	1.5	0.5	1.2	0.4	-0.3	0.7
Ever smoked	0.2	0.3	0.8	0.8	0.2	-0.4	-0.9	0.2
Basal metabolic rate	0.4	2.0	4.2	-1.9	-0.7	2.0	1.1	-0.7
Leg fat percentage (left)	0.2	0.7	1.5	-1.2	-1.2	0.2	0.2	-0.8
Arm fat-free mass (left)	0.3	1.7	4.2	-1.8	-0.3	2.1	1.0	-0.2
Number of operations (self-reported)	0.4	0.6	2.2	-0.7	0.2	0.2	1.5	-0.4
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.6	0.6	0.4	0.4	-0.8
Irritability	0.4	0.7	2.1	0.7	-0.8	0.7	-1.5	0.0
Risk taking	1.6	2.3	6.0	0.2	-1.6	1.6	-2.4	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.5	-0.1	0.2	-0.3	1.2	0.2
Fractured/broken bones in last 5 years	0.9	1.1	2.3	-1.1	-1.5	-1.0	-0.9	-0.4
Age started oral contraceptive pill	0.1	0.2	0.6	-0.4	0.0	0.1	-0.2	0.8
Diastolic blood pressure, automated reading	0.4	1.3	5.2	0.1	-0.5	2.3	-0.6	-0.8
Ever depressed for a whole week	0.9	1.2	3.3	-0.1	1.0	0.8	-0.9	1.8
Unable to work because of sickness or disability	0.1	0.1	0.5	0.0	0.1	0.4	-0.0	0.7
Commuting to job workplace: Cycle	0.8	0.9	1.8	1.1	0.7	1.3	0.9	0.5
Myopia	0.3	0.4	1.1	-1.1	-0.8	0.1	0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.8	-0.5	0.2	0.3	-0.2
Cholesterol lowering medication	1.1	1.6	3.9	0.5	0.8	2.0	-0.3	1.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	-0.4	-0.8	0.7	-1.1	-1.3
Pain experienced in last month	0.4	0.7	2.6	1.6	0.4	0.3	-0.2	0.7
Supplements: Calcium	5.6	6.2	10.9	1.0	-3.0	2.1	-3.3	-2.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.2	-0.1	-0.2	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.6	0.6	-0.5	0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.8	-0.3	0.8	-0.7	0.1
Heart disease (siblings)	1.7	2.1	4.0	1.1	-1.9	1.3	-2.0	0.0
Alcohol drinker status: Previous	0.8	0.9	2.4	-0.4	-1.5	0.4	-0.9	-1.1
Pack years of smoking	0.6	0.9	2.3	-0.3	0.9	-0.8	1.5	-0.6
Impedance of whole body	1.7	8.5	17.4	2.4	3.4	-2.5	1.3	4.2
Leg fat mass (left)	0.3	1.3	2.6	-1.6	-1.5	0.9	0.2	-1.1
Arm predicted mass (left)	0.5	2.4	6.4	-2.0	-0.3	2.5	1.1	-0.5