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chr1:45,100,098-47,339,113

Best TWAS P=1.77e-21 · Best GWAS P=5.84e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	MAST2	0.09	0.09	lasso	4	0.08	2.6e-07	-7.579	-7.3	3.3e-13	-0.45	0.98	0.01	FALSE
2	GTEx	Adipose Subcutaneous	MUTYH	0.04	0.00	enet	23	0.00	8.5e-01	4.069	-6.6	4.5e-11	-0.63	0.08	0.56	FALSE
3	GTEx	Adipose Subcutaneous	CCDC17	0.07	0.03	enet	11	0.05	3.1e-05	8.209	-7.4	1.7e-13	-0.75	0.18	0.77	TRUE
4	GTEx	Adipose Subcutaneous	GPBP1L1	0.05	0.05	lasso	4	0.05	8.7e-05	-7.563	-9.0	2.8e-19	-0.77	0.20	0.77	FALSE
5	GTEx	Adipose Subcutaneous	RP11-767N6.2	0.03	0.03	enet	6	0.04	3.0e-04	7.390	7.9	3.7e-15	0.77	0.10	0.73	FALSE
6	GTEx	Adipose Visceral Omentum	PIK3R3	0.07	0.02	lasso	3	0.04	4.6e-03	8.423	8.4	3.0e-17	0.88	0.14	0.73	TRUE
7	GTEx	Adipose Visceral Omentum	GPBP1L1	0.10	0.04	lasso	6	0.06	3.4e-04	-7.697	-9.1	6.1e-20	-0.84	0.18	0.82	TRUE
8	GTEx	Artery Aorta	MAST2	0.26	0.32	lasso	16	0.31	2.0e-17	-7.697	-7.8	8.6e-15	-0.55	0.98	0.02	FALSE
9	GTEx	Artery Aorta	TMEM69	0.09	0.02	enet	9	0.03	6.4e-03	-8.090	-5.8	5.6e-09	-0.26	0.57	0.09	FALSE
10	GTEx	Artery Coronary	MAST2	0.09	0.09	lasso	4	0.08	1.3e-03	-7.773	-7.0	3.6e-12	-0.50	0.37	0.31	FALSE
11	GTEx	Artery Tibial	MAST2	0.29	0.30	lasso	2	0.30	1.8e-23	-7.563	-7.6	3.9e-14	-0.52	1.00	0.00	FALSE
12	GTEx	Artery Tibial	GPBP1L1	0.04	0.04	enet	7	0.03	2.2e-03	7.190	-8.8	2.0e-18	-0.77	0.20	0.74	FALSE
13	GTEx	Artery Tibial	RP11-767N6.2	0.04	0.02	enet	5	0.04	6.9e-04	0.628	5.7	1.1e-08	0.81	0.08	0.86	FALSE
14	GTEx	Breast Mammary Tissue	GPBP1L1	0.06	0.02	lasso	5	0.00	2.4e-01	8.427	-8.8	1.8e-18	-0.91	0.10	0.64	FALSE
15	GTEx	Cells Transformed fibroblasts	MAST2	0.25	0.33	enet	16	0.30	1.0e-22	-7.563	-7.9	2.4e-15	-0.52	0.99	0.01	FALSE
16	GTEx	Cells Transformed fibroblasts	MUTYH	0.20	0.10	enet	22	0.11	8.3e-09	4.290	-7.2	8.6e-13	-0.56	0.87	0.13	FALSE
17	GTEx	Cells Transformed fibroblasts	GPBP1L1	0.05	0.02	enet	21	0.02	1.1e-02	-7.697	-9.5	1.8e-21	-0.71	0.17	0.69	TRUE
18	GTEx	Cells Transformed fibroblasts	IPP	0.04	0.08	lasso	1	0.08	2.3e-06	8.666	-8.7	4.5e-18	-0.99	0.04	0.95	FALSE
19	GTEx	Colon Sigmoid	MAST2	0.18	0.10	lasso	4	0.13	2.5e-05	-7.563	-8.1	4.0e-16	-0.61	0.62	0.33	FALSE
20	GTEx	Colon Transverse	MAST2	0.18	0.09	lasso	7	0.07	4.5e-04	-7.390	-6.4	1.4e-10	-0.43	0.76	0.02	FALSE
21	GTEx	Colon Transverse	GPBP1L1	0.06	0.01	lasso	6	0.01	8.3e-02	8.742	-8.6	8.2e-18	-0.88	0.08	0.79	TRUE
22	GTEx	Esophagus Mucosa	GPBP1L1	0.04	0.02	lasso	3	0.02	1.5e-02	8.752	-9.3	1.4e-20	-0.97	0.05	0.78	FALSE
23	GTEx	Esophagus Muscularis	MAST2	0.17	0.13	enet	30	0.11	3.8e-07	-7.731	-5.9	3.7e-09	-0.43	0.98	0.02	FALSE
24	GTEx	Esophagus Muscularis	CCDC17	0.04	0.04	lasso	6	0.01	9.1e-02	8.666	-8.6	9.1e-18	-0.99	0.06	0.88	FALSE
25	GTEx	Heart Atrial Appendage	MMACHC	0.10	0.06	enet	11	0.10	3.3e-05	8.398	5.7	1.5e-08	0.84	0.22	0.68	FALSE
26	GTEx	Heart Left Ventricle	MAST2	0.21	0.08	lasso	7	0.10	5.5e-06	-8.083	-5.3	1.3e-07	-0.26	0.83	0.15	FALSE
27	GTEx	Lung	MAST2	0.06	0.06	lasso	5	0.05	1.7e-04	-7.563	-7.4	1.4e-13	-0.48	0.90	0.07	FALSE
28	GTEx	Lung	GPBP1L1	0.04	0.02	enet	14	0.02	5.8e-03	8.810	-9.4	4.9e-21	-0.89	0.08	0.87	FALSE
29	GTEx	Lung	RP11-767N6.2	0.04	0.02	enet	7	0.03	3.1e-03	8.349	6.7	1.6e-11	0.92	0.06	0.90	FALSE
30	GTEx	Muscle Skeletal	MAST2	0.10	0.01	enet	14	0.03	4.0e-04	-0.074	5.3	1.1e-07	0.46	0.23	0.17	TRUE
31	GTEx	Muscle Skeletal	GPBP1L1	0.03	0.02	enet	19	0.03	7.2e-04	8.305	-6.9	6.7e-12	-0.85	0.09	0.85	FALSE
32	GTEx	Muscle Skeletal	RP11-767N6.7	0.06	0.06	lasso	3	0.04	6.6e-05	-7.890	-7.9	2.1e-15	-0.60	0.35	0.56	FALSE
33	GTEx	Nerve Tibial	TESK2	0.07	0.00	lasso	13	0.00	3.5e-01	4.069	7.0	3.8e-12	0.52	0.20	0.45	FALSE
34	GTEx	Nerve Tibial	MAST2	0.08	0.05	lasso	4	0.06	5.6e-05	-7.563	-5.3	1.0e-07	-0.25	0.76	0.02	FALSE
35	GTEx	Nerve Tibial	IPP	0.07	0.04	enet	12	0.05	1.9e-04	-8.050	-8.0	1.7e-15	-0.67	0.51	0.26	FALSE
36	GTEx	Pancreas	TESK2	0.14	0.07	lasso	2	0.07	5.7e-04	4.539	5.1	2.9e-07	0.11	0.57	0.06	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	CCDC17	0.10	0.13	lasso	6	0.13	9.6e-08	8.895	-8.6	6.7e-18	-0.99	0.03	0.97	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	GPBP1L1	0.09	0.02	enet	11	0.02	3.5e-02	8.513	-7.2	5.8e-13	-0.94	0.09	0.89	FALSE
39	GTEx	Skin Sun Exposed Lower leg	GPBP1L1	0.03	0.00	lasso	5	0.00	4.8e-01	5.522	-9.3	9.7e-21	-0.77	0.08	0.54	FALSE
40	GTEx	Skin Sun Exposed Lower leg	RP11-767N6.2	0.05	0.01	enet	13	0.02	1.6e-02	8.349	6.5	1.1e-10	0.74	0.10	0.86	FALSE
41	GTEx	Stomach	MUTYH	0.08	0.02	lasso	4	0.02	4.1e-02	4.069	-6.2	4.3e-10	-0.73	0.08	0.55	TRUE
42	GTEx	Stomach	RP11-767N6.7	0.08	0.03	enet	16	0.05	1.3e-03	-7.776	-8.7	4.4e-18	-0.68	0.29	0.29	TRUE
43	GTEx	Testis	PIK3R3	0.08	0.05	enet	7	0.06	1.5e-03	8.895	-8.7	4.0e-18	-0.99	0.06	0.89	FALSE
44	GTEx	Testis	GPBP1L1	0.07	0.06	enet	7	0.03	1.7e-02	-8.050	-8.9	4.9e-19	-0.73	0.11	0.73	FALSE
45	GTEx	Testis	IPP	0.05	0.06	enet	8	0.03	1.4e-02	8.686	8.2	2.6e-16	0.97	0.06	0.82	FALSE
46	GTEx	Testis	RP11-767N6.2	0.05	0.00	enet	14	0.01	1.1e-01	8.686	6.6	4.9e-11	0.86	0.09	0.67	FALSE
47	GTEx	Thyroid	MAST2	0.06	0.05	lasso	4	0.04	4.9e-04	8.415	-8.9	4.1e-19	-0.85	0.18	0.78	FALSE
48	GTEx	Thyroid	CCDC17	0.05	0.08	lasso	2	0.08	1.1e-06	7.395	-7.3	3.2e-13	-0.69	0.28	0.62	FALSE
49	GTEx	Thyroid	GPBP1L1	0.05	0.06	enet	6	0.07	7.9e-06	7.190	-8.9	6.0e-19	-0.85	0.14	0.86	FALSE
50	GTEx	Thyroid	IPP	0.08	0.07	lasso	3	0.08	7.1e-07	-7.731	-7.9	2.2e-15	-0.57	0.96	0.04	FALSE
51	GTEx	Uterus	MAST2	0.30	0.28	lasso	2	0.18	2.0e-04	-7.563	-7.4	9.9e-14	-0.50	0.55	0.21	FALSE
52	GTEx	Whole Blood	MAST2	0.03	0.02	lasso	3	0.02	2.9e-03	8.153	-7.1	1.4e-12	-0.89	0.14	0.71	TRUE
53	METSIM	Adipose	CCDC17	0.03	0.02	blup	287	0.01	5.6e-03	-7.752	-8.7	2.4e-18	-0.69	0.28	0.34	FALSE
54	METSIM	Adipose	MAST2	0.06	0.06	lasso	6	0.05	1.3e-08	-7.563	-8.1	7.7e-16	-0.60	0.96	0.04	FALSE
55	NTR	Blood	PIK3R3	0.01	0.02	lasso	2	0.02	4.5e-06	-7.686	-7.7	1.4e-14	-0.54	0.94	0.04	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	PIK3R3	0.05	0.02	lasso	4	0.03	4.4e-05	5.251	-5.6	2.1e-08	-0.23	0.59	0.04	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	MMACHC	0.04	0.01	blup	274	0.02	1.4e-03	-3.875	6.1	1.4e-09	0.52	0.64	0.10	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	MUTYH	0.04	0.04	blup	282	0.03	3.7e-05	4.069	5.1	3.0e-07	0.57	0.82	0.10	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	IPP	0.08	0.15	lasso	9	0.14	5.0e-18	8.531	-8.8	8.5e-19	-0.98	0.04	0.96	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	RPS15AP10	0.03	0.05	blup	283	0.04	8.0e-06	8.398	7.5	8.3e-14	0.95	0.07	0.93	FALSE
61	YFS	Blood	CCDC17	0.04	0.02	lasso	8	0.02	6.8e-08	8.630	-9.1	6.5e-20	-0.95	0.04	0.96	FALSE
62	YFS	Blood	IPP	0.10	0.11	lasso	15	0.12	4.6e-36	8.297	-7.9	2.1e-15	-0.95	0.41	0.59	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPBP1L1	0.01	0.02	lasso	2	0.02	1.2e-04	8.799	-8.8	1.4e-18	-0.99	0.02	0.96	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	MMACHC	0.01	0.00	blup	41	0.01	5.4e-03	-3.913	5.5	4.5e-08	0.33	0.02	0.57	FALSE
65	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GPBP1L1	0.05	0.05	blup	51	0.06	1.0e-03	8.531	-7.8	4.4e-15	-0.98	0.04	0.78	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPBP1L1	0.03	0.04	lasso	1	0.03	8.0e-05	8.666	-8.7	4.5e-18	-0.99	0.05	0.93	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GPBP1L1	0.07	0.10	lasso	3	0.09	6.3e-06	8.799	-8.8	1.4e-18	-0.99	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS15AP10	0.04	0.02	enet	18	0.02	1.4e-02	8.424	5.3	9.8e-08	0.75	0.03	0.87	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPBP1L1	0.04	0.04	blup	50	0.04	2.9e-05	8.752	-9.0	1.5e-19	-0.98	0.03	0.96	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMACHC	0.07	0.05	enet	12	0.09	3.1e-09	-3.875	6.4	1.9e-10	0.47	0.50	0.50	FALSE
71	The Cancer Genome Atlas	Stomach Adenocarcinoma	IPP	0.04	0.04	blup	47	0.04	1.4e-03	8.427	-9.0	2.2e-19	-0.95	0.02	0.81	FALSE
72	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM69	0.10	0.05	lasso	2	0.04	5.9e-04	-8.083	-8.1	6.3e-16	-0.59	0.12	0.54	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	GPBP1L1	0.11	0.06	lasso	3	0.06	1.6e-06	8.752	-9.3	2.1e-20	-0.98	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	MAST2	0.04	0.01	blup	97	0.02	1.8e-03	8.452	-6.0	2.5e-09	-0.74	0.03	0.74	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	MMACHC	0.09	0.05	blup	41	0.06	2.5e-06	-5.822	5.2	1.7e-07	0.44	0.04	0.96	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	PIK3R3	0.05	0.01	blup	64	0.04	4.4e-05	7.241	-7.7	1.8e-14	-0.76	0.02	0.92	TRUE