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chr7:871,369-3,581,391

Best TWAS P=2.2e-84 · Best GWAS P=6.9e-86 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	7.63	8.3	9.5e-17	-0.45	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GNA12	0.06	0.00	bslmm	603	0.02	3.7e-03	-1.18	6.8	1.1e-11	-0.43	0.13	0.07	FALSE
3	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-15.85	-16.4	1.2e-60	0.74	0.65	0.35	FALSE
4	GTEx	Adipose Visceral Omentum	GNA12	0.28	0.06	enet	46	0.08	8.0e-05	10.88	-7.6	3.8e-14	0.37	0.10	0.74	FALSE
5	GTEx	Adrenal Gland	GNA12	0.33	-0.01	enet	41	0.10	1.6e-04	3.27	-5.6	1.7e-08	0.20	0.06	0.28	FALSE
6	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-19.43	-18.9	1.4e-79	0.86	0.04	0.96	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-19.36	-19.4	1.4e-83	0.93	0.20	0.80	FALSE
8	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-19.42	-17.5	2.3e-68	0.88	0.02	0.98	FALSE
9	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-15.23	-18.2	2.1e-74	0.83	0.03	0.88	FALSE
10	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	13.32	-15.0	3.5e-51	0.62	0.24	0.74	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-15.85	-18.4	2.1e-75	0.85	0.03	0.96	TRUE
12	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-19.02	-18.9	5.1e-80	0.88	0.05	0.95	TRUE
13	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-19.43	-19.5	2.2e-84	0.96	0.02	0.98	TRUE
14	GTEx	Liver	AC004840.9	0.27	0.01	enet	27	0.06	7.0e-03	-0.66	8.4	4.3e-17	-0.38	0.07	0.19	TRUE
15	GTEx	Lung	SNX8	0.14	0.01	lasso	6	0.04	4.1e-04	-0.36	8.0	1.9e-15	-0.29	0.24	0.15	TRUE
16	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-19.00	-16.7	1.1e-62	0.77	0.02	0.98	FALSE
17	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-15.56	-18.3	1.6e-74	0.84	0.93	0.07	FALSE
18	GTEx	Prostate	MAFK	0.43	-0.01	enet	22	0.01	1.8e-01	5.58	-5.9	3.5e-09	0.04	0.05	0.09	TRUE
19	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	10.88	-12.3	5.2e-35	0.54	0.30	0.69	FALSE
20	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-15.53	-18.4	3.0e-75	0.87	0.10	0.90	FALSE
21	GTEx	Skin Sun Exposed Lower leg	AC004840.9	0.18	0.01	enet	36	0.02	3.7e-03	4.49	-7.8	5.5e-15	0.13	0.20	0.10	TRUE
22	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-15.93	-16.2	9.3e-59	0.73	0.08	0.74	FALSE
23	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-15.23	-15.4	2.8e-53	0.67	0.75	0.24	FALSE
24	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-18.52	-18.7	2.3e-78	0.95	0.02	0.94	FALSE
25	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-15.93	-16.1	3.0e-58	0.74	0.20	0.80	FALSE
26	METSIM	Adipose	MAD1L1	0.07	0.00	enet	28	0.03	9.8e-06	3.73	-6.0	1.8e-09	0.14	0.39	0.02	TRUE
27	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-12.01	-11.0	3.0e-28	0.63	0.95	0.05	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-19.43	18.5	8.2e-77	-0.94	0.01	0.99	FALSE
29	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	3.68	-8.5	2.4e-17	0.52	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM184A	0.03	0.01	lasso	2	0.02	1.5e-02	5.64	5.9	3.6e-09	-0.05	0.01	0.78	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	GNA12	0.09	0.00	blup	103	0.03	9.3e-03	-15.56	-10.8	2.8e-27	0.49	0.04	0.11	FALSE
32	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	9.64	-15.4	8.1e-54	0.73	0.01	0.70	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-15.85	-15.9	1.4e-56	0.71	0.09	0.72	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	9.64	11.7	7.8e-32	-0.63	0.05	0.86	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	10.59	-16.8	1.5e-63	0.77	0.04	0.82	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMZ1	0.14	0.06	enet	15	0.06	7.4e-08	4.42	7.1	1.7e-12	-0.32	0.83	0.04	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AMZ1	0.17	0.11	enet	9	0.10	5.0e-05	4.42	9.0	1.9e-19	-0.45	0.05	0.39	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-15.85	12.3	1.2e-34	-0.63	0.05	0.76	TRUE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1908	0.05	0.00	blup	50	0.04	1.2e-04	-3.30	-5.9	3.3e-09	0.03	0.05	0.31	TRUE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM184A	0.06	0.10	lasso	4	0.10	3.1e-10	5.57	5.3	1.4e-07	-0.04	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	-12.01	10.8	3.1e-27	-0.56	0.34	0.66	TRUE