TWAS hub - KIAA1908

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2390	0.0570	8.6e-08	0.086	0.059	0.174	0.114	0.154	1.3e-10	9.8e-08	1.2e-20	1e-13	2.9e-18
2	TCGA	Breast Invasive Carcinoma	0.0720	0.0248	1.3e-10	0.014	0.054	0.048	NA	0.048	5.8e-04	3.3e-11	3.4e-10	NA	4.3e-10
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0480	0.0251	6.1e-03	0.021	0.000	-0.001	NA	0.004	1.9e-03	2.9e-01	3.8e-01	NA	1.1e-01
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0870	0.0380	4.1e-04	0.015	0.063	0.053	NA	0.034	4.3e-02	1.7e-04	5.5e-04	NA	4.7e-03
5	TCGA	Brain Lower Grade Glioma	0.2936	0.0767	2.7e-11	0.054	0.124	0.140	NA	0.115	8.5e-07	6.1e-14	1.3e-15	NA	6.2e-13
6	TCGA	Prostate Adenocarcinoma	0.0471	0.0221	2.8e-04	0.003	0.036	0.024	NA	0.002	1.6e-01	1.2e-04	1.3e-03	NA	1.7e-01
7	TCGA	Thyroid Carcinoma	0.2940	0.0810	2.5e-09	0.035	0.103	0.122	NA	0.104	2.3e-04	3.0e-10	6.2e-12	NA	2.6e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Past tobacco smoking	8.6	15.8	32.2	-3.9	-4.6	-1.5	-5.7	-2.5	-4.3	-3.9
Loneliness, isolation	7.6	10.5	13.4	-3.5	-3.2	-1.2	-3.6	-3.2	-3.7	-3.5
Smoking Status	6.8	16.2	26.6	4.0	4.4	1.6	5.2	2.9	5.0	3.9
Ever smoked	6.5	11.5	24.3	3.4	4.0	1.0	4.9	1.8	3.9	3.1
Heart disease (mother)	6.1	7.4	11.2	2.2	2.7	2.4	3.3	2.5	2.9	2.8
Smoking status: Previous	6.1	9.1	19.3	2.9	3.6	1.1	4.4	1.9	3.3	2.9
Mouth/teeth dental problems: Bleeding gums	4.3	5.5	12.9	-3.6	-2.0	-0.5	-1.8	-2.4	-2.0	-2.9
Average weekly spirits intake	4.1	5.1	10.0	3.2	2.0	1.4	2.2	2.1	1.6	2.7
Bipolar Disorder or Schizophrenia	4.0	9.9	18.8	4.3	2.3	1.9	2.8	3.3	3.7	2.9
Schizophrenia (2018)	3.9	8.1	17.1	4.1	1.8	0.5	2.2	3.3	3.7	2.6
Tinnitus: Yes, but not now, but have in the past	3.5	3.8	6.5	-2.3	-2.3	-1.1	-1.8	-2.2	-0.7	-2.5
Shortness of breath walking on level ground	3.1	3.7	7.2	1.6	2.1	0.9	2.7	1.6	1.8	2.3
Pain type(s) experienced in last month: Hip pain	3.1	3.9	6.2	2.4	2.1	0.5	2.5	1.9	1.3	2.4
Commuting to job workplace: Car/motor vehicle	3.0	3.4	4.4	-1.8	-2.1	-1.4	-2.0	-1.8	-2.0	-1.7
Vitamin and mineral supplements	2.8	3.8	7.4	1.4	2.2	1.8	2.7	1.0	1.5	2.4
Osteoporosis (self-reported)	2.8	3.5	6.0	1.9	2.3	1.2	2.1	1.4	1.2	2.4
Guilty feelings	2.8	4.2	8.8	-1.7	-2.0	-1.4	-3.0	-1.5	-2.6	-1.8
Multivitamins +/- minerals	2.7	3.4	6.0	-1.4	-2.1	-1.7	-2.4	-1.4	-1.4	-2.2
Respiratory disease	2.6	5.7	10.4	2.7	1.9	1.9	3.2	1.3	2.6	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	6.3	-2.5	-0.9	-0.6	-1.2	-2.2	-1.9	-1.7
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	7.8	2.0	1.3	0.8	1.8	1.3	2.8	1.5
Medication: Co-codamol	2.4	2.7	4.9	1.5	2.2	1.1	2.2	0.5	1.8	1.6
Depressed Affect (Nagel 2018)	2.3	4.8	6.9	-2.0	-2.1	-0.6	-2.5	-2.6	-2.6	-2.3
Health satisfaction	2.3	3.0	4.5	1.9	1.4	1.2	1.9	1.4	2.1	1.9
Miserableness	2.3	4.0	6.6	-2.4	-1.8	-0.2	-2.6	-1.9	-1.9	-2.2
Sitting height	2.2	15.5	35.0	-4.8	-3.1	-0.8	-3.0	-4.2	-5.9	-3.7
Schizophrenia (2014)	2.1	4.6	9.9	3.1	1.8	0.6	2.0	2.2	2.3	2.1
Medication: Atenolol	2.1	2.7	5.5	1.7	1.5	0.7	1.6	1.9	2.3	1.3
Exposure to tobacco smoke at home	2.1	2.4	3.2	1.7	1.8	1.3	1.3	1.8	1.0	1.8
Severe depression (siblings)	2.0	2.3	4.6	1.6	1.6	-0.3	1.0	1.4	2.1	1.8
Long-standing illness, disability or infirmity	2.0	3.0	6.4	2.5	1.6	-0.1	1.3	2.0	1.8	1.9
Asthma (self-reported)	2.0	4.0	7.9	2.0	1.6	1.7	2.8	1.3	2.3	1.9
Illnesses of father: None of the above (group 1)	2.0	2.5	6.6	-0.7	-1.3	-2.1	-1.4	-1.0	-2.6	-1.0
Risk taking	2.0	2.9	4.7	-2.0	-1.9	0.4	-2.0	-1.0	-2.2	-1.6
Lung cancer (father)	1.9	2.2	3.8	-1.4	-1.2	-1.5	-2.0	-1.5	-1.6	-1.1
Commuting to job workplace: Walk	1.9	2.1	5.0	1.3	0.6	1.9	0.7	2.2	1.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.7	1.9	1.3	0.5	1.5	1.6	1.4	1.5
Fasting Glucose	1.7	2.1	4.1	-1.2	-1.8	0.1	-1.5	-1.3	-1.3	-2.0
Father’s age at death	1.7	2.2	4.5	-2.1	-1.3	-0.5	-0.9	-1.7	-1.1	-2.0
Asthma	1.7	3.3	6.9	1.7	1.3	1.9	2.6	1.1	2.0	1.7
Mouth/teeth dental problems: Dentures	1.6	2.8	6.2	2.5	1.9	-0.1	1.1	1.5	1.3	2.1
Emphysema/chronic bronchitis	1.6	1.8	3.6	1.6	1.1	0.9	1.5	1.1	1.9	0.9
Smoking status: Current	1.6	2.5	5.3	1.6	1.8	0.7	1.7	1.1	2.3	1.6
Bipolar Disorder (2018)	1.5	2.4	6.5	1.7	1.5	2.5	1.9	0.0	1.2	0.0
Lupus	1.5	2.3	3.7	-1.8	-1.4	-0.8	-1.7	-1.9	-1.3	-1.6
Relative age voice broke	1.5	2.2	5.2	0.9	1.2	2.3	1.6	1.1	1.9	0.9
Heart attack	1.5	1.9	4.5	1.5	1.3	-0.0	0.8	1.5	2.1	1.4
HbA1C	1.4	1.6	3.9	0.8	1.2	1.3	1.0	1.2	2.0	1.1
Pulse rate	1.4	2.4	4.4	-2.0	-1.1	0.6	-1.8	-1.6	-2.1	-1.2
Back pain experienced in last month	1.4	2.1	8.1	2.9	0.6	-0.7	1.0	0.6	1.6	1.4
Diastolic blood pressure, automated reading	1.4	4.3	10.4	-0.5	-2.3	-1.8	-3.2	-0.7	-3.1	-0.7
Commuting to job workplace: Cycle	1.4	1.7	4.3	0.8	1.3	1.2	2.1	-0.2	1.9	0.5
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.8	1.4	1.2	-0.2	0.9	1.4	2.2	1.3
Number of treatments/medications taken	1.3	2.3	3.7	1.9	1.7	0.4	1.4	1.2	1.7	1.6
Mean time to correctly identify matches	1.3	2.4	6.2	2.5	1.6	0.0	1.4	1.1	1.7	1.4
Medication: Ramipril	1.2	1.6	3.6	1.6	1.4	0.4	1.0	1.3	0.6	1.9
Alcohol intake versus 10 years previously	1.2	1.8	3.8	1.1	2.0	0.6	1.8	0.5	1.6	1.1
Illnesses of mother	1.2	1.5	2.1	-1.3	-1.5	-0.4	-1.3	-0.8	-1.5	-1.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.9	1.0	1.7	0.5	1.4	0.4	1.0	1.6
Pulse rate, automated reading	1.2	3.9	9.0	-1.6	-1.7	-0.7	-3.0	-1.5	-3.0	-1.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	2.7	-1.7	-1.0	0.7	-1.1	-1.1	-1.5	-1.1
Myopia	1.2	1.8	4.5	0.9	1.3	1.7	2.1	0.4	0.2	1.5
Alzheimer’s Disease (including proxy)	1.1	1.5	3.3	0.1	-1.7	-1.0	-1.8	0.6	1.3	-1.2
Prostate Cancer	1.1	1.5	2.6	-1.6	-0.9	0.7	-0.4	-1.5	-1.6	-1.4
Tanning	1.1	13.8	19.9	3.0	4.0	1.8	4.1	4.1	4.5	3.8
Relative age of first facial hair	1.1	2.2	4.3	0.8	1.8	1.3	1.5	1.2	2.1	1.3
Pack years adult smoking proportion	1.1	1.7	3.9	-0.7	-1.5	-1.2	-2.0	-1.3	-0.5	-1.4
Hair/balding pattern: Pattern 3	1.1	1.6	3.7	0.3	-1.9	-1.3	-1.3	-0.8	-1.6	-1.0
Leg fat-free mass (right)	1.1	5.7	14.5	-3.8	-1.0	-0.3	-1.1	-2.8	-3.4	-2.0
Leg predicted mass (right)	1.1	6.1	15.1	-3.9	-1.1	-0.4	-1.1	-2.9	-3.5	-2.1
Average weekly champagne plus white wine intake	1.1	1.5	3.3	-1.8	-0.6	0.2	-1.1	-1.3	-1.6	-1.3
Commuting to job workplace: Public transport	1.1	1.4	2.6	0.7	1.6	1.2	1.3	1.1	0.6	1.3
Average weekly beer plus cider intake	1.1	1.6	5.6	2.4	0.6	-1.1	1.0	0.3	1.4	1.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.4	1.6	-0.4	-2.1	0.3	0.8	1.1	0.4
Pack years of smoking	1.1	1.6	3.7	-0.7	-1.3	-1.4	-1.9	-1.2	-0.7	-1.2
Ovarian Cancer	1.0	1.3	2.7	1.3	-0.7	-1.6	-1.2	0.8	-1.4	0.4
Age at First Birth	1.0	1.5	2.5	-0.9	-1.5	-0.6	-1.4	-1.2	-0.8	-1.6
Impedance of leg (right)	1.0	4.7	12.0	3.5	0.7	-0.7	0.8	3.0	2.6	1.9
Allergy	1.0	2.2	6.3	-2.5	0.5	1.1	-0.8	-1.7	-1.9	-0.7
Trunk fat-free mass	1.0	5.7	11.6	-3.4	-1.4	-1.1	-1.2	-2.9	-3.2	-2.2
Time employed in main current job	1.0	1.1	1.5	-0.8	-0.9	-1.1	-1.2	-1.2	-1.0	-1.2
Noisy workplace	1.0	1.2	3.0	-0.6	-0.6	-1.3	-1.2	-1.7	-1.0	-0.9
Trunk predicted mass	1.0	5.5	11.0	-3.3	-1.4	-1.1	-1.2	-2.8	-3.2	-2.2
Medication: Amlodipine	1.0	1.4	1.7	1.2	1.2	1.0	1.3	0.8	1.3	1.3
Whole body fat-free mass	1.0	5.6	12.4	-3.5	-1.2	-0.8	-1.2	-2.8	-3.4	-2.0
Whole body water mass	1.0	5.5	12.0	-3.5	-1.2	-0.8	-1.1	-2.8	-3.4	-2.0
Alzheimer’s Disease (in father)	0.9	1.0	2.1	-0.2	-0.9	-1.5	-1.3	0.4	1.1	-1.1
Mean Putamen Volume	0.9	1.0	2.8	-0.3	-0.9	-1.2	-1.4	0.1	-1.7	-0.2
Neuroticism (2016)	0.9	1.3	4.2	0.9	-1.0	-1.5	-2.1	0.4	-0.8	-0.3
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.4	-1.6	-0.8	0.7	-0.7	-1.3	-1.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.3	1.6	0.3	-0.8	-0.2	1.8	0.7	1.0
Current tobacco smoking	0.9	1.4	3.7	1.1	1.3	0.7	1.1	0.7	1.9	1.0
Chronic bronchitis/emphysema (father)	0.9	1.0	6.1	-0.6	-0.1	2.5	0.2	-0.6	-0.4	-0.3
Impedance of leg (left)	0.9	4.2	10.8	3.3	0.8	-0.7	1.0	2.5	2.6	1.8
Pain all over the body in last month	0.9	1.0	3.0	0.8	1.0	0.6	1.1	0.8	1.7	0.5
Prospective memory result	0.9	1.1	2.1	-0.7	-1.2	-0.7	-1.1	-1.1	-0.7	-1.4
Number of full brothers	0.9	1.1	3.6	0.5	1.0	1.9	1.1	0.3	0.9	0.9
Comparative height size at age 10	0.9	4.9	16.6	-2.6	-0.8	-1.6	-1.5	-1.7	-4.1	-1.7
Overall health rating	0.9	2.0	3.6	1.9	1.2	0.0	1.5	1.1	1.8	1.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.2	1.1	0.4	1.5	1.3	0.7	1.3	0.2
Medication: Atorvastatin	0.9	1.1	2.2	0.1	1.3	1.5	1.3	-1.2	-0.3	0.4
Lung FVC	0.8	4.2	17.2	1.8	1.1	0.1	1.4	2.0	4.2	1.2
Sensitivity / hurt feelings	0.8	1.4	2.7	1.2	1.3	1.6	0.7	1.0	0.3	1.6
Diabetes (father)	0.8	0.9	3.2	-0.7	-0.9	-0.3	-0.5	-1.8	-0.9	-1.0
Leg fat-free mass (left)	0.8	4.5	11.4	-3.4	-0.8	-0.5	-1.0	-2.3	-3.1	-1.7
Leg predicted mass (left)	0.8	4.5	11.4	-3.4	-0.7	-0.5	-1.0	-2.3	-3.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.8	-2.2	-1.1	0.9	-0.0	-1.5	-1.1	-1.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.6	-0.2	-1.3	-1.6	-0.9	-0.8	0.1	-1.2
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	-0.5	-1.1	-0.6	-0.8	-0.9	-1.5	-0.9
Loud music exposure frequency	0.8	0.9	2.1	1.2	0.4	0.2	1.1	0.9	1.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.2	-1.2	-1.3	0.4	-0.2	-1.5	-1.2	-1.4
Number of full sisters	0.8	1.0	2.4	-0.9	-0.5	-1.6	-0.6	-1.3	-1.1	-0.2
Had major operations	0.8	1.0	3.0	-1.0	-0.6	-0.5	-0.8	-0.9	-1.7	-0.8
Diabetes diagnosed by doctor	0.8	1.2	2.0	-1.1	-1.4	-0.6	-1.4	-1.2	-0.4	-1.2
Basal metabolic rate	0.8	4.6	11.2	-3.4	-0.8	-0.6	-0.9	-2.5	-3.1	-1.7
Reaction Time	0.7	1.4	4.1	2.0	1.1	0.1	1.2	0.4	1.4	0.8
Systolic blood pressure, automated reading	0.7	2.1	5.9	0.1	-1.6	-1.7	-2.4	-0.4	-1.6	-0.6
Maternal smoking around birth	0.7	1.0	3.2	-1.8	-1.0	0.2	-0.9	-0.4	-0.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.4	-1.6	-0.7	-0.0	-1.0	-1.1	-0.4	-1.3
Age when periods started (menarche)	0.7	1.6	4.1	1.5	0.6	0.0	1.9	0.9	2.0	0.4
Medication: Omeprazole	0.7	0.9	3.6	1.2	-0.7	-1.9	-0.1	0.7	0.3	0.3
Arm predicted mass (right)	0.7	3.5	8.4	-2.9	-0.7	-0.3	-0.7	-2.3	-2.8	-1.3
Age at last live birth	0.7	1.0	2.0	-1.4	-1.0	-1.1	-1.3	-0.4	0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.8	-1.7	-0.2	0.9	0.2	-1.2	-1.9	-0.8
Medication for cholesterol	0.7	1.0	2.9	-1.5	-0.0	-0.9	-0.3	-0.7	-1.7	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	4.1	-0.3	0.6	2.0	0.9	-0.3	-0.6	0.3
Age started oral contraceptive pill	0.7	0.9	3.0	-0.1	-0.9	-0.9	-1.7	-0.3	-1.1	-0.7
Depression (Nagel 2018)	0.6	1.0	2.4	-1.2	-0.5	0.2	-0.7	-1.6	-1.0	-1.0
Ulcerative Colitis (UC)	0.6	1.0	1.9	1.2	0.9	0.8	1.0	0.2	1.4	1.2
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.0	-1.4	-0.9	-0.8	-1.1	-1.4	-0.9	-1.1
Supplements: Zinc	0.6	0.6	1.2	0.9	0.8	0.0	0.6	1.1	0.7	1.0
Diabetes (mother)	0.6	0.8	3.2	1.8	0.6	-0.7	0.4	0.2	0.3	1.1
Fed-up feelings	0.6	1.1	1.8	-0.9	-1.2	-0.1	-1.0	-1.1	-1.1	-1.4
Taking other prescription medications	0.6	0.9	1.5	1.2	1.0	-0.4	1.0	0.5	1.2	0.9
Qualifications: CSEs or equivalent	0.6	0.8	1.2	-0.5	-1.1	-0.9	-1.1	-1.0	-0.5	-1.0
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.7	1.0	0.8	1.2	0.4	1.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.1	1.0	0.7	-1.1	0.6	0.8	0.7	1.1
Alcohol usually taken with meals	0.6	1.0	2.7	-1.6	-1.0	-0.0	-1.4	-0.2	-0.8	-1.0
Qualifications: None of the above	0.6	1.3	2.3	1.1	1.5	1.2	1.3	0.1	1.0	1.2
Medication: Lansoprazole	0.6	0.7	1.2	-0.7	-0.5	-0.8	-0.3	-0.9	1.1	-1.1
Standing height	0.6	6.2	15.8	-3.2	-1.5	-1.6	-1.5	-2.3	-4.0	-2.2
Breastfed as a baby	0.6	0.7	1.5	0.7	0.7	0.6	1.2	1.1	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-0.8	-1.4	-1.2	-0.8	-1.0	0.0	-1.6
High blood pressure (siblings)	0.6	0.9	2.0	1.4	0.2	-1.1	-0.5	1.2	0.7	0.8
Arm fat-free mass (right)	0.6	3.3	7.8	-2.8	-0.7	-0.2	-0.7	-2.2	-2.8	-1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.5	-0.9	-1.0	-0.7	-1.2	-0.6	-0.6	-1.0
Migraine (self-reported)	0.6	0.8	1.1	-0.9	-1.1	-1.0	-1.0	-0.7	-0.6	-0.9
Leg pain on walking	0.6	0.8	2.1	1.2	0.4	-0.2	0.9	0.9	1.5	0.6
Mineral and other dietary supplements	0.6	0.9	1.7	-1.0	-1.3	-0.3	-0.7	-1.0	-0.8	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.2	1.0	1.1	0.6	1.1	0.6	0.3	1.0
Medication: Paracetamol	0.6	1.0	2.4	1.0	1.4	-0.3	1.0	0.3	1.6	0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.8	-0.4	-0.3	-0.5	-0.6	-0.0	-1.9	-0.0
Pain experienced in last month	0.6	1.0	2.3	-1.3	-0.8	0.3	-1.5	0.4	-1.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.5	-0.2	-0.9	-1.0	-1.2	0.7	0.3	-1.0
Alcohol drinker status: Previous	0.6	0.7	1.9	0.6	0.1	1.4	0.7	0.7	1.3	0.3
Arm predicted mass (left)	0.6	3.0	7.6	-2.6	-0.6	-0.5	-0.8	-2.0	-2.8	-1.2
Neuroticism (Nagel 2018)	0.5	1.2	4.0	-0.1	-1.0	0.2	-1.5	-0.8	-2.0	-0.5
Irritable Bowel Disease (IBD)	0.5	1.1	2.0	1.3	1.3	0.5	0.9	0.3	1.1	1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	-0.2	-1.3	-1.6	-1.1	-1.0	-1.2	-0.7
Rheumatoid Arthritis	0.5	0.8	1.7	0.2	0.9	1.3	1.0	0.4	1.0	0.6
Systolic Blood Pressure	0.5	2.4	7.6	-0.3	-2.1	-0.7	-2.8	-0.7	-1.6	-1.1
Hand grip strength (left)	0.5	1.4	3.1	-1.2	-1.7	0.2	-0.3	-1.6	-0.3	-1.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.5	1.6	-1.1	-1.6	-0.2	0.8	0.6	-0.0
Supplements: Glucosamine	0.5	0.6	1.2	0.7	1.0	0.2	1.1	0.8	0.7	0.8
Hearing difficulty/problems with background noise	0.5	0.8	1.5	-0.3	-0.9	-1.2	-1.2	-0.3	-0.7	-1.0
Had other major operations	0.5	0.6	2.2	0.0	0.6	-0.2	1.1	0.4	1.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	0.9	0.7	0.7	1.2	0.5	0.8	0.7
Medication: Simvastatin	0.5	0.7	1.8	1.1	0.1	-0.4	-0.4	1.3	0.9	0.9
Illnesses of siblings	0.5	0.7	1.7	-1.3	-0.1	1.3	0.7	-0.6	-0.6	-0.5
Falls in the last year	0.5	0.7	1.4	-1.0	-0.3	0.7	-0.8	-1.0	-1.2	-0.5
Medication: Cholesterol lowering	0.5	0.9	1.4	1.1	0.7	-0.5	-0.2	1.2	1.1	1.2
Glaucoma (self-reported)	0.5	0.6	1.9	-0.4	-0.1	-0.7	0.7	-1.4	-0.4	-0.8
Gout (self-reported)	0.5	0.7	2.2	0.1	0.8	1.5	0.7	1.0	-0.6	0.5
Birth weight	0.5	1.1	4.3	0.4	1.1	-0.8	0.7	0.8	2.1	0.1
Age at first live birth	0.5	0.9	1.3	-1.1	-0.9	-0.7	-1.1	-1.1	-0.4	-1.0
Pulse wave peak to peak time	0.5	0.6	1.5	0.2	1.1	0.6	0.8	0.5	1.2	0.8
Medication: Ibuprofen	0.5	0.5	1.1	-1.0	0.6	1.1	0.9	-0.7	0.1	-0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.6	0.3	-1.1	-1.2	-0.6	-0.5	-0.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-1.0	-0.3	0.5	-0.3	-1.3	-0.9	-0.3
Supplements: Vitamin C	0.5	0.6	1.5	-0.6	-0.7	-0.1	-0.4	-1.2	-1.0	-1.0
Medication: Gliclazide	0.5	0.5	1.2	-0.8	0.1	0.8	0.5	-1.1	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.4	0.8	-1.5	-1.5	-0.7	0.3	1.1	-0.3
Ever taken oral contraceptive pill	0.5	0.5	1.6	-1.2	-0.3	-0.1	0.0	-1.2	-0.3	-0.8
Medication: Blood pressure	0.5	1.0	1.6	1.3	0.5	1.2	0.6	1.1	1.1	0.8
Alcohol drinker status: Never	0.5	0.6	1.3	-1.1	-0.5	0.1	-1.1	-0.7	0.4	-0.8
Leg fat percentage (left)	0.5	1.7	3.1	1.0	1.6	-0.7	1.3	1.2	1.1	1.8
Arm fat-free mass (left)	0.5	2.3	6.1	-2.4	-0.2	-0.3	-0.3	-1.8	-2.5	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.1	-1.3	-0.4	-0.6	0.2	-1.8	-2.0	-0.8
Supplements: Calcium	0.5	0.6	2.1	-1.4	0.0	0.6	0.5	-0.7	-0.0	-0.9
Impedance of whole body	0.5	2.7	6.5	2.4	0.7	-0.5	0.3	2.5	1.9	1.5
Breast Cancer	0.4	1.0	4.2	-0.1	0.4	1.1	1.0	0.1	2.1	0.1
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	0.7	0.8	0.1	0.7	0.8	0.9	0.5
Hand grip strength (right)	0.4	1.2	3.6	-0.5	-1.9	0.2	-0.5	-1.4	-1.1	-1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.8	0.2	0.5	0.1	0.2	0.7	1.7	-0.0
High blood pressure	0.4	1.0	2.2	1.4	0.1	0.3	-0.3	1.5	1.4	0.8
Stomach or abdominal pain in last month	0.4	0.5	1.4	1.0	-0.3	-1.2	-0.4	0.5	0.2	0.7
Had menopause	0.4	0.5	1.2	0.0	-0.4	-1.1	-0.9	-0.1	-1.0	-0.3
Diabetes (self-reported)	0.4	0.7	1.0	-1.0	-0.9	-0.1	-1.0	-0.9	-0.4	-1.0
Neuroticism score	0.4	0.8	1.9	-0.6	-0.8	-0.0	-1.3	-0.7	-1.4	-0.7
Number of live births	0.4	0.6	1.4	-0.7	-0.9	1.2	-0.4	-0.5	0.5	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	-0.8	0.5	1.1	0.6	-0.8	-0.3	-0.2
Birth weight of first child	0.4	0.6	1.3	-1.1	-0.7	-0.9	-0.8	-0.4	-0.3	-1.0
Peak expiratory flow (PEF)	0.4	0.9	3.6	-1.9	-0.1	0.4	0.8	-0.7	0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.1	1.5	-0.7	-0.6	-0.5	0.8	-0.4	0.8
Blood clot in the leg (DVT)	0.4	0.5	1.2	0.1	-0.6	-0.8	-1.1	1.0	0.3	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	-0.1	-0.3	0.5	0.9	-0.7	1.1	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	2.6	-1.6	-1.5	-0.7	-0.5	-1.4	-0.4	-1.4
Leg fat percentage (right)	0.4	1.5	2.9	1.0	1.4	-0.9	1.0	1.3	1.0	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	1.2	0.1	-0.1	0.0	0.9	0.4	0.8
Qualifications: College or University degree	0.4	1.2	2.7	-1.6	-1.6	-0.5	-0.4	-0.6	-1.0	-1.4
Eye problems/disorders: None of the above	0.4	0.4	1.8	0.7	0.2	0.0	0.6	0.7	1.3	0.3
Neck or shoulder pain in last month	0.4	0.6	3.0	0.3	-0.4	-1.7	-0.2	-0.4	0.7	-0.4
Medication: Blood pressure	0.4	0.6	1.7	0.9	0.3	-1.3	-0.3	1.0	0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.5	0.9	-0.2	0.7	0.9	0.1	1.1
Suffer from ‘nerves’	0.4	0.6	1.7	1.3	-0.3	-0.7	-0.0	0.1	-1.2	0.5
Hypertension (Self-reported)	0.4	1.2	2.7	1.6	0.3	0.3	-0.1	1.7	1.4	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-0.6	-1.2	0.6	-0.5	-0.5	0.2	-1.1
Osteoarthritis (self-reported)	0.4	0.5	1.5	1.2	0.2	0.1	0.5	0.3	0.7	0.9
Wears glasses or contact lenses	0.4	0.5	2.0	0.8	0.2	-1.4	0.1	0.6	0.4	0.1
Hearing aid user	0.4	0.5	1.6	0.0	-0.6	-1.3	-0.7	-0.5	0.0	-0.6
Eye problems/disorders: Glaucoma	0.4	0.4	1.0	-0.2	0.2	-0.9	0.5	-0.9	-1.0	-0.2
Medication: Lisinopril	0.4	0.6	2.0	1.0	0.2	-0.6	-0.3	1.4	0.1	0.7
Unable to work because of sickness or disability	0.4	0.5	2.3	0.7	-0.4	0.0	-0.5	-0.0	1.5	-0.3
Cholesterol lowering medication	0.4	0.6	1.6	1.3	0.3	0.9	0.4	0.2	0.9	0.7
Worry (Nagel 2018)	0.3	0.6	2.4	1.6	-0.4	0.2	-0.4	0.0	-1.1	0.6
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	0.1	-1.1	-0.3	-0.8	-0.1	0.3	-0.6
Cardiovascular Disease	0.3	0.8	3.1	0.7	0.3	1.8	0.1	0.8	1.1	0.7
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.2	-0.4	0.9	-0.1	-0.2	0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.9	-1.4	-0.7	0.9	0.0	-0.4	-0.6	-0.6
Number of incorrect matches in round	0.3	0.5	1.1	-0.1	-0.6	-1.0	-1.1	-0.4	-0.2	-0.6
Financial difficulties in last 2 years	0.3	0.4	1.1	0.5	0.1	-0.4	0.2	0.9	1.0	0.6
Weight	0.3	1.6	5.2	-2.3	0.2	-0.6	-0.2	-1.2	-1.9	-0.4
Impedance of arm (right)	0.3	1.3	3.3	1.4	0.8	-0.9	0.2	1.8	1.1	0.9
Happiness	0.3	0.4	1.0	-0.4	-0.8	-1.0	-0.4	-0.3	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	-1.4	-1.4	-0.8	-0.6	-0.8	-0.3	-1.1
Pulse wave reflection index	0.3	0.4	1.7	1.3	0.1	-0.4	0.9	0.3	-0.0	0.6
Medication: Paracetamol	0.3	0.5	1.3	1.1	0.9	-0.1	0.6	0.3	0.9	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	0.1	-0.3	-1.0	-0.3	0.6	0.8	-0.6
Body fat percentage	0.3	1.0	2.8	0.1	1.7	-0.6	0.8	1.1	0.5	1.4
Worry too long after embarrassment	0.3	0.4	0.8	0.3	0.2	0.9	-0.9	0.6	-0.7	0.7
Medication: Allopurinol	0.3	0.3	0.7	-0.7	-0.5	-0.4	-0.5	0.0	-0.9	-0.7
Knee pain experienced in last month	0.3	0.5	1.3	0.4	0.9	-0.4	1.0	-0.2	1.1	0.3
Average weekly red wine intake	0.3	0.4	0.9	0.5	-0.9	-0.4	-0.2	0.9	0.6	-0.4
Friendships satisfaction	0.3	0.3	1.0	-0.2	-0.8	0.5	-1.0	-0.3	-0.3	-0.3
Breast cancer (self-reported)	0.3	0.3	0.9	-0.3	0.1	-0.2	-0.9	1.0	-0.7	0.3
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	1.0	-0.3	-0.7	-0.6	1.2	0.6	0.4
Mother’s age at death	0.3	0.4	1.0	1.0	0.7	-0.1	0.4	0.4	0.0	0.9
High cholesterol (Self-reported)	0.3	0.6	1.4	1.1	0.6	1.2	0.3	0.1	0.9	0.6
Number of operations (self-reported)	0.3	0.4	1.0	0.0	1.0	0.2	0.9	0.4	0.8	0.2
Irritability	0.3	0.5	1.2	1.1	0.4	-1.0	0.3	0.7	-0.2	0.6
Heart disease (siblings)	0.3	0.3	1.0	1.0	-0.0	-0.8	-0.3	-0.0	-0.4	0.7
Crohns Disease (2012)	0.2	0.3	1.8	0.0	-0.4	0.2	-0.5	0.0	-1.3	0.0
Ulcerative Colitis	0.2	0.2	0.3	0.5	0.3	0.6	0.5	-0.1	0.6	0.6
Blood White Count	0.2	1.3	3.1	-0.9	-0.9	0.0	-1.3	-1.8	0.0	-1.6
Heel T-Score	0.2	1.6	3.0	-1.7	-1.7	-0.3	-0.9	-0.9	-1.2	-1.6
Height	0.2	4.8	22.5	-1.2	-0.5	-2.5	-1.0	-1.2	-4.7	-0.6
Waist Hip Ratio (WHR)	0.2	0.9	3.1	0.6	0.0	1.2	1.8	0.3	1.0	0.1
Allergy or Eczema	0.2	0.5	1.3	1.1	-0.7	-0.9	0.1	0.7	0.7	-0.1
Lung FEV1/FVC ratio	0.2	1.2	5.8	-0.5	-0.8	-2.4	-0.9	-0.0	-0.8	-0.6
Neuroticism	0.2	0.4	1.8	0.2	-0.5	-0.1	-0.7	-0.6	-1.3	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.3	-0.8	-0.2	-0.5	0.1	-0.2	-0.7
Medication: Metformin	0.2	0.3	1.2	1.1	0.0	-0.4	0.3	0.4	0.3	0.6
Trunk fat percentage	0.2	0.8	2.5	-0.4	1.6	-0.5	0.6	0.9	0.2	1.1
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.2	-0.9	-0.3	-0.8	-0.5	-0.2	-0.7
Waist circumference	0.2	0.7	2.0	-0.5	1.2	0.7	1.4	0.3	0.3	0.9
Nervous feelings	0.2	0.3	0.6	0.2	-0.7	0.7	-0.6	-0.5	-0.8	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	0.6	-0.2	0.4	-1.0	0.4	-0.4	-0.0
Arm fat percentage (right)	0.2	0.8	2.6	-0.1	1.6	-0.6	0.8	0.8	0.5	1.2
Worrier / anxious feelings	0.2	0.3	1.5	0.4	0.6	0.3	-0.1	-0.2	1.2	0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	0.5	-0.6	0.7	0.9	0.4	-0.3	0.7
Depression (self-reported)	0.2	0.3	0.7	0.7	0.5	0.2	0.8	0.4	0.2	0.6
Length of working week for main job	0.2	0.2	0.5	-0.2	0.1	-0.6	0.0	-0.6	0.7	-0.6
Headache pain in last month	0.2	0.3	0.6	-0.4	-0.7	-0.0	-0.6	-0.8	0.3	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	1.6	-0.3	0.0	-0.5	-0.4	-0.2	1.3	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	2.1	0.2	-0.3	1.4	0.3	-0.5	0.6	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	1.6	0.2	0.4	0.2	0.0	1.2	-0.1	0.6
Illnesses of father: Heart disease	0.2	0.2	1.1	0.1	0.3	-0.0	0.1	0.0	1.0	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.8	0.3	0.9	0.3	0.6	-0.4	0.4	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.6	-0.4	0.8	-0.0	0.5	0.0	-0.6
Mood swings	0.2	0.3	1.4	-0.0	-0.7	1.2	-0.4	-0.3	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	-0.3	-0.0	-0.8	-0.5	-0.2	0.0	-0.2
Qualifications: nursing, teaching	0.2	0.2	0.6	-0.8	0.3	-0.4	0.0	0.7	0.7	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.4	-0.1	0.4	0.4	-0.6	0.7	-0.2
Medication: Aspirin	0.2	0.2	0.8	-0.3	-0.3	-0.2	-0.9	-0.5	-0.5	-0.1
Financial situation satisfaction	0.2	0.2	0.7	0.8	0.1	-0.7	-0.2	-0.1	0.3	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.8	0.0	0.7	0.7	-0.4	0.4	-0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.3	-0.6	0.1	-0.0	-0.7	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.4	-0.4	-0.7	-0.7	0.3	-0.6	-0.0
Crohns Disease (2017)	0.1	0.3	0.8	0.9	0.7	-0.1	0.2	-0.1	0.1	0.8
Body Mass Index (BMI) (2010)	0.1	0.1	0.8	-0.9	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.1	0.2	1.1	-1.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.5	-0.8	0.3	-0.5	0.1	-0.2	-0.3
Blood Eosinophil Count	0.1	0.7	3.3	0.9	-0.3	0.6	0.1	0.2	1.8	0.1
Blood Platelet Count	0.1	1.5	9.9	-0.5	0.2	0.5	0.3	0.1	3.1	-0.5
Blood Red Count	0.1	0.8	2.8	0.2	0.0	1.4	0.3	0.6	-1.7	0.8
BMI	0.1	0.4	1.1	-1.1	0.0	-0.6	0.3	-0.7	-0.8	-0.1
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.2	-0.7	-0.6	-0.0	-0.0	0.8	-0.8
Chronotype (morning person)	0.1	0.2	0.5	0.7	-0.3	-0.7	-0.3	0.1	0.3	-0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.0	-0.1	-0.7	-0.8	-0.3	-0.2	-0.2
Angina	0.1	0.1	0.4	0.6	0.0	-0.3	-0.3	-0.1	0.4	0.2
Townsend deprivation index at recruitment	0.1	0.1	0.5	-0.7	-0.4	-0.3	-0.2	-0.3	-0.0	-0.2
Body mass index (BMI)	0.1	0.3	0.8	-0.9	0.9	0.2	0.5	-0.2	-0.2	0.5
Trunk fat mass	0.1	0.5	1.5	-1.2	0.9	-0.8	0.2	-0.0	-0.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.6	0.5	-0.3	0.3	0.3	0.4	0.3
Forced vital capacity (FVC)	0.1	0.3	1.2	-1.1	-0.5	-0.2	0.3	-0.3	0.4	-0.5
Mouth/teeth dental problems	0.1	0.1	0.2	0.4	-0.0	0.3	0.3	0.2	-0.3	0.5
Hip circumference	0.1	0.6	1.5	-1.2	1.2	0.2	0.6	-0.0	-0.8	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.2	0.2	0.8	0.4	-0.9	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.3	-1.1	-0.9	-0.9	-0.3	-0.1	0.2	-0.7
Impedance of arm (left)	0.1	0.7	1.8	1.0	0.6	-0.5	-0.1	1.3	0.9	0.6
Arm fat mass (right)	0.1	0.5	1.4	-1.1	1.2	-0.4	0.5	-0.1	-0.6	0.6
Tense / ‘highly strung’	0.1	0.2	0.5	-0.1	-0.3	-0.5	-0.6	-0.3	-0.7	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.2	-0.8	0.7	-0.1	-0.1	0.1	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	1.0	-0.2	0.1	-0.5	-1.0	-0.1	-0.5	0.2
Comparative body size at age 10	0.1	0.3	1.1	-0.3	0.5	-1.1	-0.4	0.5	0.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.4	0.0	0.6	0.7	0.2	-0.1	0.4
Number of children fathered	0.1	0.1	0.3	0.2	0.0	-0.5	-0.2	0.2	-0.2	-0.0
Angina (self-reported)	0.1	0.1	0.4	0.6	-0.1	-0.3	-0.4	-0.0	0.2	0.2
Whole body fat mass	0.1	0.5	1.1	-1.0	0.9	-0.8	0.2	-0.1	-0.7	0.5
Leg fat mass (right)	0.1	0.4	0.8	-0.5	0.9	-0.7	0.5	0.1	-0.4	0.7
Alcohol intake frequency.	0.1	0.2	1.3	-0.2	0.3	-0.0	0.2	-0.1	1.1	-0.3
Chest pain or discomfort	0.1	0.2	0.4	0.6	0.4	-0.3	-0.2	0.5	0.2	0.6
Family relationship satisfaction	0.1	0.1	0.3	0.2	-0.6	0.2	-0.1	-0.4	-0.1	-0.3
Medication: Aspirin	0.1	0.1	0.4	-0.3	-0.1	0.2	-0.6	-0.6	-0.1	-0.1
Arm fat percentage (left)	0.1	0.6	2.0	-0.5	1.4	-0.3	0.6	0.4	0.3	0.9
Ever had bowel cancer screening	0.1	0.1	0.1	0.4	-0.3	0.1	-0.4	0.2	0.2	-0.0
Eye problems/disorders: Cataract	0.1	0.2	0.6	-0.3	0.3	0.8	0.4	-0.4	-0.1	0.1
Arm fat mass (left)	0.1	0.6	1.8	-1.3	1.1	-0.3	0.4	-0.3	-0.7	0.4
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.4	0.3	0.6	0.5	-0.1	-0.4	-0.1
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	0.1	-0.1	0.0	-0.5	0.4	-0.3
Leg fat mass (left)	0.1	0.4	1.1	-0.5	1.1	-0.6	0.8	0.1	-0.3	0.8
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.2	0.4	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.4	0.6	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	1.8	-0.2	-1.3	0.7	-1.2	-0.3	0.5	-0.8
Average weekly fortified wine intake	0.0	0.0	0.2	0.0	-0.4	-0.0	-0.0	0.2	-0.0	-0.3
High blood pressure (mother)	0.0	0.0	0.1	0.0	0.1	0.1	0.1	-0.2	-0.3	0.1
Fluid intelligence score	0.0	0.0	0.1	0.1	-0.1	-0.3	0.4	-0.2	0.2	0.1

Hub : Genes

KIAA1908

Models

Trait associations