TWAS hub - ATP5J2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1330	0.0460	1.0e-04	0.058	NA	0.072	NA	0.055	1.7e-05	NA	1.7e-06	NA	2.8e-05
2	GTEx	Artery Coronary	0.2670	0.1240	6.0e-03	0.064	NA	0.000	NA	0.037	3.5e-03	NA	3.3e-01	NA	2.1e-02
3	GTEx	Artery Tibial	0.0945	0.0474	5.3e-03	0.050	NA	0.066	NA	0.056	8.8e-05	NA	7.5e-06	NA	3.1e-05
4	GTEx	Brain Cerebellum	0.2740	0.0900	1.1e-03	0.030	NA	-0.006	NA	0.001	4.5e-02	NA	5.3e-01	NA	3.0e-01
5	GTEx	Breast Mammary Tissue (Female)	0.1316	0.0905	3.2e-02	0.042	NA	0.103	NA	0.065	2.2e-02	NA	5.5e-04	NA	5.3e-03
6	GTEx	Cells Transformed fibroblasts	0.1560	0.0600	3.7e-03	0.043	NA	0.040	NA	0.042	3.6e-04	NA	5.1e-04	NA	4.1e-04
7	GTEx	Esophagus Muscularis	0.1040	0.0510	4.0e-03	0.050	NA	0.043	NA	0.059	5.4e-04	NA	1.3e-03	NA	1.8e-04
8	GTEx	Heart Left Ventricle	0.2932	0.1057	1.9e-03	0.037	NA	0.050	NA	0.041	4.8e-03	NA	1.2e-03	NA	3.1e-03
9	GTEx	Skin Sun Exposed Lower leg	0.1610	0.0520	1.2e-05	0.094	NA	0.098	NA	0.093	3.4e-08	NA	1.6e-08	NA	4.0e-08
10	GTEx	Testis	0.2090	0.0650	1.4e-06	0.134	NA	0.144	NA	0.190	1.6e-06	NA	6.4e-07	NA	7.5e-09
11	GTEx	Thyroid	0.1890	0.0590	3.1e-04	0.003	NA	0.055	NA	0.032	1.6e-01	NA	5.2e-05	NA	1.6e-03
12	METSIM	Adipose	0.0763	0.0271	6.9e-08	0.077	0.053	0.070	0.069	0.073	1.3e-11	1.8e-08	1.1e-10	1.4e-10	5.1e-11
13	YFS	Blood	0.0219	0.0085	2.2e-05	0.018	0.007	0.005	0.011	0.011	1.4e-06	1.4e-03	5.1e-03	8.5e-05	9.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
HbA1C	11.3	12.6	19.5	-2.5	-4.2	-4.3	-3.2	-2.5	-4.1	-4.3	-2.6	-2.7	-3.6	-2.5	-4.4	4.1
Hayfever/allergic rhinitis (self-reported)	9.1	12.0	18.9	-3.6	-2.0	-2.8	-4.3	-2.3	-3.6	-4.2	-2.9	-4.1	-3.6	-3.6	-3.5	3.8
Heart disease (siblings)	6.3	7.8	14.2	2.1	3.8	2.4	1.9	1.4	2.7	3.2	2.7	3.8	3.2	1.4	2.8	-3.4
Rheumatoid Arthritis	5.2	7.2	11.3	-2.8	-2.7	-2.4	-2.2	-2.1	-2.9	-3.1	-2.1	-3.1	-3.4	-2.0	-3.1	2.7
Medication: Seretide 50 evohaler	4.2	4.9	9.3	-3.0	-2.2	-2.7	-0.5	-1.4	-2.5	-2.4	0.4	-2.4	-1.3	-2.8	-2.5	2.3
Illnesses of siblings	4.0	5.6	10.3	-2.3	-2.6	-1.9	-2.8	-1.7	-2.2	-2.6	-0.2	-3.2	-2.8	-1.8	-2.7	2.6
Supplements: Fish oil (including cod liver oil)	3.9	5.2	10.6	-2.5	-1.3	-1.6	-1.4	-1.6	-2.3	-3.1	-2.4	-2.2	-3.3	-0.7	-2.9	2.7
Heart disease (mother)	3.8	4.7	11.4	2.1	2.2	1.6	3.4	1.3	2.1	2.0	1.3	1.8	2.9	2.3	1.6	-2.5
Fractured/broken bones in last 5 years	3.7	4.8	8.2	-2.7	-2.8	-2.0	-1.7	-1.7	-2.0	-2.2	-1.1	-2.9	-2.7	-1.5	-2.0	2.5
Allergy or Eczema	3.6	9.5	19.1	-2.9	-2.2	-3.2	-2.9	-0.4	-3.4	-3.9	-4.4	-2.6	-3.5	-2.0	-3.6	3.1
Vitamin and mineral supplements	3.5	4.7	10.0	2.8	1.1	1.5	1.6	2.3	2.2	2.8	0.0	3.2	2.1	1.3	2.5	-2.6
Mineral and other dietary supplements	3.5	4.6	9.3	2.3	1.0	2.0	1.1	1.9	2.2	2.8	2.1	2.3	3.0	0.2	3.0	-2.2
Pulse rate, automated reading	3.4	11.1	22.2	2.2	2.6	3.2	3.0	3.4	3.8	4.2	2.9	3.9	4.7	0.7	3.8	-3.2
Deep venous thrombosis (DVT) (self-reported)	3.3	4.2	9.9	-0.8	-2.3	-1.4	-2.6	-1.0	-2.3	-2.5	0.0	-2.4	-2.4	-1.1	-2.3	3.1
Glaucoma (self-reported)	3.1	3.6	6.8	1.4	2.0	1.5	2.0	2.0	2.6	2.2	0.0	1.6	1.8	1.3	2.6	-2.2
Eye problems/disorders: Glaucoma	3.0	3.5	7.0	1.6	1.4	1.4	2.2	2.6	2.4	2.0	0.6	1.6	1.9	1.1	2.4	-2.0
Blood Red Count	2.8	26.7	49.6	5.1	4.5	3.9	-1.7	4.4	7.0	6.5	-3.1	6.3	5.1	3.8	6.3	-6.5
Smoking Status	2.8	6.7	17.1	1.6	1.2	2.0	2.3	3.6	2.4	2.0	4.0	2.8	4.1	2.0	2.5	-1.1
Cardiovascular Disease	2.8	9.2	19.7	2.7	3.5	2.7	2.4	1.5	2.7	3.5	1.9	3.4	4.4	2.0	3.3	-3.8
Allergy	2.7	6.2	10.2	2.0	2.0	2.6	2.8	0.5	2.9	3.2	2.4	2.8	2.5	1.8	2.8	-2.8
Systolic blood pressure, automated reading	2.6	7.5	12.5	2.8	3.4	3.1	1.8	2.0	3.0	3.1	-0.6	3.5	3.0	2.5	2.4	-2.8
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.9	12.1	2.4	2.3	2.6	3.4	1.0	2.6	2.5	0.8	2.4	3.5	1.7	2.6	-2.6
Fluid intelligence score	2.6	5.3	15.0	2.2	1.6	2.5	2.7	1.0	2.6	2.2	1.5	1.3	1.9	3.9	2.6	-2.6
Exposure to tobacco smoke at home	2.6	3.0	7.0	-1.4	-2.6	-1.2	-1.3	-0.7	-1.8	-2.1	-1.1	-1.2	-1.5	-1.9	-1.7	2.6
Mother’s age at death	2.6	3.3	7.4	-1.8	-1.0	-1.7	-0.7	-1.7	-1.8	-2.3	-1.0	-2.7	-2.5	-1.4	-1.8	2.0
Lung FEV1/FVC ratio	2.5	12.8	31.2	3.3	3.5	5.6	2.4	3.6	4.6	4.2	-0.2	2.7	3.0	3.3	4.3	-3.0
Past tobacco smoking	2.5	4.6	11.5	-2.5	-1.1	-1.7	-2.0	-2.8	-1.8	-1.6	-2.3	-2.6	-3.4	-2.0	-2.1	0.8
Medication: Simvastatin	2.5	3.6	9.6	3.1	2.1	2.1	0.2	1.3	1.6	1.9	0.8	2.0	2.8	0.8	2.2	-1.7
Pulse wave peak to peak time	2.5	3.0	5.3	-0.8	-1.8	-1.4	-1.2	-1.4	-1.9	-2.1	-2.1	-1.7	-2.3	-1.8	-1.5	1.8
Birth weight of first child	2.4	4.4	9.5	2.7	1.7	2.1	2.0	1.3	2.7	2.6	0.5	1.2	0.5	3.1	2.5	-2.0
Blood clot in the leg (DVT)	2.4	3.2	7.7	-0.5	-2.1	-1.3	-2.3	-0.9	-1.9	-2.1	0.0	-2.0	-1.9	-0.9	-2.0	2.8
Medication: Blood pressure	2.4	4.5	8.4	1.8	2.2	2.6	1.8	1.6	2.0	2.5	1.5	1.9	2.9	1.1	2.5	-2.5
Supplements: Calcium	2.4	2.7	8.2	-2.6	-0.9	-1.1	-0.9	-0.1	-1.4	-1.9	-0.1	-2.0	-2.9	-0.8	-2.1	1.5
Age at First Birth	2.3	3.4	7.5	-1.1	-0.9	-2.2	-2.3	-1.9	-2.1	-1.9	-1.1	-2.1	-2.7	-1.1	-2.2	1.3
Hayfever, allergic rhinitis or eczema	2.3	5.0	8.4	-2.9	-1.1	-2.1	-2.4	-0.5	-2.4	-2.9	-2.3	-2.2	-2.5	-1.6	-2.6	2.3
Medication for cholesterol	2.3	3.5	6.2	-1.4	-1.4	-1.8	-1.9	-2.4	-2.3	-2.5	-0.2	-1.4	-2.4	-0.9	-2.1	2.2
Vascular/heart problems diagnosed by doctor	2.3	6.4	17.6	-2.3	-2.7	-2.1	-1.9	-1.1	-2.3	-3.0	-1.1	-2.8	-4.2	-1.5	-2.8	3.1
Type 2 Diabetes (T2D) (2018)	2.2	4.2	11.4	3.0	1.8	2.2	1.6	2.5	1.5	1.5	-1.0	2.2	3.4	-0.5	2.1	-1.5
High blood pressure	2.2	6.3	15.6	2.2	2.8	1.9	2.1	1.5	2.2	2.8	1.0	3.1	4.0	1.6	2.7	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	10.4	2.9	1.8	2.5	2.5	1.2	2.1	2.0	0.3	2.6	3.2	2.0	2.4	-2.3
Medication: Aspirin	2.2	2.9	8.0	2.8	0.6	1.1	1.2	1.8	1.4	1.8	0.4	1.3	2.1	2.8	1.5	-1.2
Ever smoked	2.2	3.8	11.7	2.3	0.6	1.6	1.9	2.8	1.5	1.3	2.1	2.0	3.4	1.6	1.9	-0.4
Diastolic blood pressure, automated reading	2.2	6.8	15.3	1.8	2.4	2.7	1.2	2.0	3.1	3.1	0.7	3.9	3.2	2.5	2.7	-2.8
Pulse rate	2.1	3.6	7.0	0.8	2.1	1.6	0.4	1.5	2.0	2.5	2.5	2.6	2.5	0.6	2.0	-1.7
Hair/balding pattern: Pattern 4	2.1	5.2	10.3	2.2	2.0	2.3	2.0	0.8	2.8	2.8	0.9	2.6	2.0	1.6	3.2	-2.9
Medication: Amlodipine	2.1	3.0	5.8	1.3	1.5	2.4	0.9	2.1	1.7	1.7	2.0	2.0	2.2	1.0	1.8	-1.2
Hypertension (Self-reported)	2.1	5.8	14.6	2.3	2.6	1.9	1.9	1.7	2.1	2.7	0.7	2.9	3.8	1.3	2.6	-3.0
Financial situation satisfaction	2.1	2.6	5.8	-0.9	-2.4	-1.5	-1.1	-0.7	-1.8	-1.8	-0.7	-1.7	-1.0	-2.4	-1.4	2.3
Mean Putamen Volume	2.0	2.3	7.1	0.8	2.2	1.4	0.8	-0.7	1.1	1.7	2.7	0.7	1.7	1.4	1.6	-1.6
Multivitamins +/- minerals	2.0	2.6	6.7	-1.8	-0.4	-0.9	-1.5	-2.1	-1.4	-2.0	0.2	-2.6	-1.6	-0.0	-1.9	2.0
Pulse wave Arterial Stiffness index	2.0	2.4	3.9	0.6	1.6	1.2	1.2	1.1	1.7	1.9	2.0	1.6	2.0	1.7	1.3	-1.6
Diabetes diagnosed by doctor	2.0	3.3	7.6	2.7	1.1	2.1	1.4	2.3	1.5	1.4	-1.2	1.9	2.7	-0.1	1.9	-1.4
Pain type(s) experienced in last month: Hip pain	2.0	2.5	8.1	1.6	0.1	0.5	-0.3	2.1	1.9	1.6	-0.1	1.3	1.9	2.8	1.6	-1.7
Triglycerides	1.9	3.1	5.1	2.0	1.3	1.7	1.4	1.5	2.0	1.9	0.9	2.2	2.2	1.1	2.1	-2.1
Chest pain or discomfort	1.9	2.7	6.8	2.3	0.9	0.8	2.0	0.5	1.2	1.8	0.8	1.6	2.6	1.9	1.4	-1.8
Major Depression (MDD)	1.8	2.1	4.8	0.7	1.3	2.0	1.4	0.7	1.4	1.3	0.9	2.2	1.5	2.2	1.1	-1.4
Number of live births	1.8	2.5	4.8	1.9	1.3	2.2	0.1	2.2	1.2	1.5	-0.5	1.5	1.7	2.1	1.5	-1.4
Depression (self-reported)	1.8	2.2	4.7	-1.3	-0.6	-0.4	-1.6	-0.9	-1.6	-2.2	-2.0	-1.1	-1.4	-1.1	-1.8	1.9
Medication: Aspirin	1.8	2.3	5.9	2.4	0.4	1.2	0.8	2.0	1.2	1.6	0.6	0.9	2.0	2.3	1.4	-1.0
Average weekly beer plus cider intake	1.8	2.6	6.5	1.9	1.1	1.4	0.8	2.1	1.3	1.5	0.0	2.4	2.6	1.2	1.7	-1.1
Lupus	1.7	2.5	4.6	0.9	2.1	1.8	1.3	1.5	2.1	1.8	1.1	1.2	1.5	1.1	2.1	-1.6
Medication: Cholesterol lowering	1.7	2.7	7.9	2.1	1.5	0.6	0.9	1.1	1.4	1.7	0.4	2.8	2.6	0.8	1.3	-1.8
Pulse wave reflection index	1.7	2.1	5.2	0.5	1.3	1.1	1.6	0.3	1.4	1.4	2.3	1.2	1.1	2.1	1.4	-1.8
Leg fat percentage (right)	1.7	6.3	16.6	2.6	1.7	2.8	1.0	2.9	2.1	2.6	0.9	3.7	4.1	1.6	2.6	-1.6
Medication: Bendroflumethiazide	1.7	2.6	5.5	1.6	0.8	1.3	1.7	2.0	1.8	1.8	-0.3	2.3	2.0	-0.0	2.0	-1.6
Leg fat percentage (left)	1.7	6.3	18.2	2.9	1.7	2.8	1.1	2.8	2.1	2.6	0.7	3.6	4.3	1.3	2.6	-1.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.9	-1.8	-2.0	-1.6	-1.6	-0.2	-1.2	-1.1	-1.1	-1.0	-0.6	-0.9	-1.2	1.9
Illnesses of mother	1.6	1.9	5.6	-1.4	-1.1	-1.0	-1.4	-2.4	-1.3	-1.1	0.8	-1.6	-1.4	-1.5	-0.8	1.4
Breastfed as a baby	1.6	2.0	7.6	2.8	0.5	0.9	0.0	1.1	1.4	1.3	0.4	1.6	1.3	2.2	1.6	-1.2
Reaction Time	1.5	2.8	6.4	1.4	0.6	1.0	1.6	2.0	2.0	1.9	0.3	1.8	2.5	-0.9	2.2	-1.9
Systolic Blood Pressure	1.5	7.6	12.5	2.0	3.4	2.4	2.1	1.4	3.3	3.3	0.6	3.5	2.9	2.9	2.9	-3.4
Lung FVC	1.5	7.8	17.5	-1.2	-4.2	-2.9	-2.5	-4.1	-3.0	-2.8	-1.3	-2.5	-3.4	-1.6	-2.6	2.5
Chronotype (morning person)	1.5	3.6	11.7	-2.9	-0.7	-0.5	-0.7	-3.4	-2.2	-2.1	-0.4	-1.8	-2.7	-0.5	-1.8	1.3
Diabetes (mother)	1.5	1.9	7.8	-0.2	1.6	0.5	1.4	2.8	0.7	1.2	1.6	1.5	2.0	-0.0	1.0	-1.0
Worrier / anxious feelings	1.5	2.9	6.3	0.9	2.0	1.6	1.8	0.2	2.2	2.3	0.9	1.3	1.2	1.9	1.7	-2.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	7.8	-1.6	-1.4	-0.5	-1.1	-1.4	-1.5	-1.7	-0.3	-2.5	-2.8	-0.9	-1.2	1.8
Forced vital capacity (FVC), Best measure	1.5	5.3	19.8	-1.4	-2.8	-2.0	-1.1	-4.4	-2.0	-1.9	-1.8	-2.7	-2.8	-1.3	-1.6	2.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.5	1.2	1.1	2.0	1.0	1.3	1.0	1.3	1.6	1.1	2.1	0.4	1.2	-0.9
Qualifications: nursing, teaching	1.5	2.3	4.3	-1.1	-2.1	-1.1	-1.1	-1.0	-2.0	-1.8	-1.4	-1.6	-1.7	-0.8	-1.8	1.7
Alcohol drinker status: Never	1.5	1.9	5.4	-2.0	-0.2	-1.2	-0.2	-1.8	-1.4	-1.4	-0.8	-2.3	-1.5	-0.9	-1.0	0.8
Breast Cancer	1.4	3.4	9.4	1.0	2.7	1.6	1.5	0.0	1.6	1.8	3.1	2.0	1.0	0.8	2.1	-2.3
Fasting Glucose	1.4	1.7	4.6	-0.5	-0.6	-1.2	-1.2	-2.1	-1.5	-1.3	-0.9	-1.1	-1.2	-1.6	-1.6	1.3
High blood pressure (siblings)	1.4	2.0	3.8	0.7	1.8	1.4	2.0	0.2	1.5	1.4	-0.5	1.8	1.7	1.1	1.5	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.7	1.3	1.7	1.0	1.6	1.0	1.3	1.0	0.5	1.6	1.9	0.6	1.3	-1.1
Breast cancer (self-reported)	1.4	1.6	4.9	-0.4	-1.4	-0.6	-1.7	-0.4	-1.2	-1.2	-1.1	-2.2	-1.4	-0.4	-1.1	1.8
Number of treatments/medications taken	1.3	2.4	6.9	0.8	1.5	1.0	0.3	2.6	1.6	1.6	-0.2	1.8	2.1	1.5	1.1	-2.0
Sitting height	1.3	9.1	35.0	-1.4	-2.3	-2.1	-1.8	-5.9	-2.6	-2.6	-3.0	-3.8	-4.2	-1.5	-2.0	2.6
Had menopause	1.3	1.6	3.5	-0.9	-0.9	-0.6	-1.9	0.9	-1.0	-1.3	-1.4	-1.2	-1.9	-1.0	-1.5	1.2
Diabetes (self-reported)	1.3	2.0	6.1	2.1	0.5	1.4	1.1	2.1	0.7	0.7	-1.6	1.3	2.5	-1.0	1.2	-0.5
Medication: Lansoprazole	1.3	1.5	5.8	0.3	-1.3	-0.8	-1.5	-0.5	-0.8	-1.2	-1.6	-1.2	-0.8	2.4	-1.0	1.2
Intelligence (Savage-Jansen 2018)	1.2	3.7	9.9	3.1	1.2	2.2	1.6	0.7	2.3	1.9	0.2	1.5	1.7	2.4	2.3	-1.9
Ovarian Cancer	1.2	1.7	3.5	1.2	1.3	1.6	1.0	1.0	1.0	1.1	0.9	1.9	1.6	1.4	1.2	-1.0
Blood Platelet Count	1.2	13.5	28.7	4.0	0.9	2.3	4.4	5.4	4.3	4.2	3.1	3.0	4.2	4.0	3.8	-1.4
Qualifications: CSEs or equivalent	1.2	1.6	3.9	0.3	0.6	1.7	1.6	2.0	0.9	0.7	0.7	1.7	1.5	1.8	0.7	-0.8
Serious illness, injury or assault to yourself	1.2	1.4	3.7	-1.4	-1.2	-0.9	-1.8	-0.6	-0.8	-1.3	0.5	-1.9	-1.0	-0.5	-1.2	1.3
Stomach or abdominal pain in last month	1.2	1.5	3.4	-1.5	-1.4	-0.5	-1.4	-0.5	-1.2	-1.2	-0.1	-1.8	-0.7	-1.2	-1.5	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.2	-0.5	-1.7	0.5	-1.4	-0.6	-1.0	-1.8	-0.9	-1.6	-1.3	0.1	-1.1	1.1
Mean time to correctly identify matches	1.2	2.3	5.7	1.9	-0.3	0.7	1.4	2.4	1.4	1.3	-1.2	1.8	2.2	-1.3	1.5	-1.2
Smoking status: Previous	1.2	1.8	5.5	1.8	0.9	0.8	1.3	1.0	1.1	1.0	1.2	1.7	2.4	1.6	1.2	-0.4
Schizophrenia vs Biploar Disorder	1.1	1.4	5.0	-0.6	-0.2	-0.5	-1.8	-0.8	-1.1	-1.0	-0.8	-1.5	-2.2	-0.9	-1.4	1.2
HDL Cholesterol	1.1	1.8	3.3	-1.7	-0.8	-1.8	-0.9	-1.3	-1.2	-1.3	-0.3	-1.8	-1.8	-0.7	-1.6	1.4
Heel T-Score	1.1	8.8	21.8	3.0	3.4	3.7	2.4	0.3	2.8	2.8	-1.5	3.2	4.7	2.3	3.1	-3.2
Respiratory disease	1.1	2.5	5.2	-1.6	-2.1	-2.0	-0.9	0.1	-2.3	-2.1	-1.4	-1.1	-0.8	0.2	-1.9	1.9
Angina (self-reported)	1.1	1.4	3.5	0.8	1.6	0.8	1.4	-0.0	1.0	1.2	1.9	0.5	1.8	0.8	1.0	-1.3
Coronary Artery Disease (CAD)	1.0	1.2	3.1	0.5	1.8	0.6	0.6	-0.4	0.8	1.2	0.4	1.4	1.1	1.6	0.8	-1.7
Waist Hip Ratio (WHR)	1.0	4.5	12.4	1.7	1.5	1.4	2.2	2.9	1.3	1.9	3.5	2.6	2.7	0.1	2.0	-1.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	3.4	-1.1	-1.2	-1.3	-0.8	-0.1	-1.2	-1.4	-0.9	-1.8	-1.0	-0.4	-1.3	1.5
Pack years adult smoking proportion	1.0	1.5	5.8	1.5	0.4	0.5	0.8	1.2	0.9	1.2	-0.0	2.4	2.3	-0.1	1.1	-0.9
Waist circumference	1.0	3.6	12.7	2.9	0.9	2.5	0.6	1.9	1.1	1.8	1.5	1.9	3.6	-0.0	2.1	-0.3
Noisy workplace	1.0	1.3	3.8	0.7	-0.1	1.2	1.9	1.3	1.1	0.7	1.4	1.0	0.9	1.8	0.9	-0.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.4	-1.2	-0.5	-1.3	-1.4	-0.2	-1.2	-1.6	-0.3	0.0	-0.6	-0.3	-1.5	1.8
Number of full brothers	1.0	1.2	3.5	0.1	1.7	1.3	0.8	0.3	0.9	0.9	-0.1	1.7	1.9	0.1	1.2	-1.1
Medication for pain relief, constipation, heartburn	1.0	1.8	5.1	-1.4	-0.6	-1.3	-0.9	-1.9	-1.1	-1.4	-0.7	-0.9	-2.3	-1.3	-1.4	1.3
Medication: Blood pressure	1.0	1.8	5.9	1.5	0.9	0.6	1.0	1.0	0.9	1.4	1.0	1.9	2.4	1.3	1.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.7	-1.0	-0.1	0.1	1.3	2.2	0.9	0.6	1.6	0.6	0.5	1.8	0.5	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.8	0.3	-1.0	0.1	-1.3	-0.2	-1.1	-1.2	-0.5	-0.7	-1.3	2.0	-1.2	1.3
Medication: Lisinopril	1.0	1.2	4.0	0.3	1.5	1.3	0.5	0.5	1.0	1.4	0.6	1.1	2.0	-0.0	1.2	-1.3
Risk taking	1.0	1.4	3.9	-1.2	-1.9	-1.3	0.0	-1.2	-1.3	-1.1	0.9	-2.0	0.1	-0.7	-0.8	1.1
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.6	-1.3	-0.1	-1.3	-1.4	-1.2	-1.0	-1.3	-0.3	-0.9	-1.6	0.2	-0.9	0.8
Bipolar Disorder (2011)	0.9	0.9	2.6	0.4	-0.3	0.2	1.6	-0.1	1.0	0.8	-0.5	1.3	1.6	0.9	0.9	-0.7
BMI	0.9	5.4	23.6	3.1	0.9	2.7	1.0	2.8	1.5	2.2	1.3	2.2	4.9	1.1	2.4	-0.6
Height	0.9	17.6	75.7	-2.5	-2.5	-3.7	-2.8	-8.7	-3.8	-3.2	-3.8	-3.4	-5.9	-3.8	-3.1	2.9
Hand grip strength (left)	0.9	2.3	13.9	-1.0	-0.2	-1.1	-0.9	-3.7	-1.2	-1.0	0.2	-1.4	-2.7	0.2	-1.0	0.6
Angina	0.9	1.1	3.4	0.5	1.3	0.7	1.3	-0.2	0.8	1.0	1.8	0.3	1.8	0.4	0.9	-1.2
Medication: Co-codamol	0.9	1.0	2.6	0.5	-1.1	-1.6	-1.0	-0.4	-0.7	-0.8	-0.9	-1.1	-0.6	-1.4	-1.0	1.0
Trunk fat percentage	0.9	3.6	9.4	2.4	1.9	2.5	0.5	1.3	1.4	2.0	0.8	2.8	3.1	0.7	2.0	-1.2
Relative age voice broke	0.9	1.4	3.8	-0.5	1.3	1.3	0.6	-2.0	1.4	1.0	1.5	0.5	-0.2	1.7	0.6	-1.3
Taking other prescription medications	0.9	1.4	4.1	-0.6	-0.9	-1.4	-2.0	0.4	-1.2	-1.5	-1.5	-0.8	-1.1	0.2	-1.1	1.1
Medication: Atenolol	0.9	1.1	2.2	1.5	0.2	0.5	0.7	0.9	1.1	1.1	1.1	0.9	1.0	1.5	1.5	-0.9
Body mass index (BMI)	0.9	4.0	15.5	2.4	0.9	2.8	0.5	2.3	1.5	2.0	0.8	2.1	3.9	0.5	2.2	-0.3
Length of working week for main job	0.9	1.0	6.3	-0.4	-1.6	-0.0	-0.4	-1.0	-0.7	-0.2	-0.4	-0.9	-0.7	-2.5	-0.3	0.5
Peak expiratory flow (PEF)	0.9	2.2	4.5	-0.7	-1.9	-1.0	-1.3	-0.9	-0.9	-1.3	-2.0	-1.6	-2.1	1.3	-1.4	1.9
Body fat percentage	0.9	3.7	11.4	2.4	1.7	2.4	0.4	1.7	1.4	1.9	0.8	2.8	3.4	0.6	2.0	-0.9
Worry too long after embarrassment	0.9	1.5	5.0	1.1	0.7	0.8	1.1	-0.2	1.4	1.3	0.1	1.3	1.0	2.2	1.0	-2.0
Number of full sisters	0.9	1.1	3.2	1.8	0.0	0.9	-0.2	0.8	1.0	1.0	-0.6	1.7	1.4	0.7	1.1	-0.7
Average weekly red wine intake	0.9	1.3	3.8	1.5	0.6	1.5	1.0	1.0	0.7	0.5	-0.5	2.0	1.2	1.8	1.0	0.2
Hearing aid user	0.9	1.0	3.3	-0.9	-0.1	-1.4	-1.5	0.3	-0.6	-0.3	-1.8	-0.2	-1.3	-0.8	-1.2	0.3
Commuting to job workplace: Public transport	0.9	1.1	2.5	-1.0	0.1	-0.6	-1.1	-1.6	-1.3	-0.9	1.2	-1.4	-0.3	-1.0	-0.6	1.2
High cholesterol (Self-reported)	0.9	1.7	4.8	0.8	2.2	1.1	0.1	1.6	0.8	1.3	0.1	1.8	1.1	1.8	0.6	-1.6
Medication: Atorvastatin	0.9	1.1	2.8	-1.6	-0.2	-0.9	-1.2	-0.3	-1.4	-1.1	-0.2	-0.7	-1.0	-0.7	-1.7	0.9
Myopia	0.9	1.2	4.9	-1.5	0.2	-0.5	-1.6	-2.2	-0.6	-1.0	-0.6	-0.8	-1.6	-0.6	-0.8	0.6
Alcohol drinker status: Previous	0.9	1.0	2.7	0.7	0.4	0.4	-0.0	1.6	1.3	1.1	-0.5	1.5	1.2	1.0	1.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.7	2.0	0.7	1.4	1.2	0.9	1.5	1.1	1.0	0.7	1.1	2.4	1.7	-1.3
Crohns Disease (2012)	0.8	1.3	4.8	1.1	-0.9	0.7	0.5	1.8	1.1	0.7	-1.0	1.5	-0.1	2.2	1.2	-0.7
LDL Cholesterol	0.8	1.2	2.3	-0.9	-0.9	-1.4	-1.5	-1.5	-0.9	-1.1	-1.1	-0.5	-1.2	-0.4	-1.1	1.2
Current tobacco smoking	0.8	1.4	7.1	0.1	-0.4	0.3	0.3	2.7	0.5	0.6	2.3	1.2	1.2	1.1	0.5	-0.3
Arm fat percentage (right)	0.8	3.2	10.2	2.1	1.1	2.7	0.2	2.0	1.1	1.6	1.2	2.2	3.2	0.8	1.7	-0.5
Standing height	0.8	7.5	30.1	-0.9	-1.8	-2.1	-1.8	-5.5	-2.7	-2.5	-2.5	-2.6	-4.1	-1.7	-2.1	2.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	0.8	0.8	1.4	0.8	0.1	1.0	1.1	1.7	0.9	0.9	0.6	1.1	-0.8
Loud music exposure frequency	0.8	0.8	2.5	0.3	0.4	1.2	0.3	1.5	1.0	0.7	1.0	0.3	1.6	0.1	1.2	-0.5
Exposure to tobacco smoke outside home	0.8	1.1	5.2	-0.6	-2.3	-1.0	-0.8	-1.3	-1.2	-0.9	-0.6	-0.6	-0.1	-0.6	-0.7	1.3
Arm fat percentage (left)	0.8	3.3	11.1	2.2	1.1	2.8	0.2	1.8	1.2	1.7	1.1	2.2	3.3	0.6	1.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.5	-0.8	-1.2	0.4	-0.8	-1.0	-0.8	-0.5	-0.2	-1.4	-1.6	-1.4	-0.7	0.6
Smoking status: Current	0.8	1.3	6.5	0.2	-0.3	0.6	0.3	2.6	0.7	0.7	2.1	1.1	1.2	1.2	0.6	-0.4
Irritable Bowel Disease (IBD)	0.7	1.7	6.7	0.9	-1.8	-0.1	0.1	2.6	0.8	0.3	-1.3	1.0	-0.9	2.5	0.8	-0.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	8.3	0.3	0.3	0.3	-0.9	-0.1	0.0	-0.2	-2.9	-0.0	-0.3	0.8	-0.1	0.3
Average weekly spirits intake	0.7	0.9	3.8	-0.7	-1.8	-0.7	-1.2	0.5	-0.6	-0.4	-0.3	-0.2	0.4	-1.9	-0.4	1.0
Hearing difficulty/problems: Yes	0.7	1.0	2.3	0.8	1.0	1.2	0.4	1.5	0.8	1.2	0.6	1.3	1.0	1.4	0.8	-0.6
Medication: Metformin	0.7	1.0	3.8	2.0	0.4	1.0	0.4	1.0	0.5	0.6	-1.1	0.7	1.9	-0.1	1.1	-0.4
Townsend deprivation index at recruitment	0.7	0.9	4.3	0.3	0.7	0.4	0.1	1.3	0.4	0.4	2.1	1.3	1.4	-0.8	0.9	-0.4
Maternal smoking around birth	0.7	1.0	3.9	-0.2	-0.4	-0.8	-0.0	0.5	-0.8	-0.9	-1.6	2.0	1.0	-0.7	-1.3	1.1
Supplements: Glucosamine	0.7	0.9	1.9	-0.6	1.0	-0.0	0.4	-1.2	-0.7	-1.1	-1.1	-1.4	-1.3	0.8	-1.3	0.4
Forced vital capacity (FVC)	0.7	2.6	8.9	-0.7	-2.6	-1.2	-0.8	-3.0	-1.3	-1.2	-1.1	-1.6	-2.3	-0.9	-0.9	1.6
Trunk fat-free mass	0.7	4.0	9.7	-0.2	-2.8	-1.0	-1.7	-2.5	-2.2	-2.0	-1.8	-2.4	-1.5	-1.6	-1.1	3.1
Happiness	0.7	0.8	3.1	-0.7	-1.2	0.5	-0.4	0.6	-1.2	-1.2	-0.3	-0.8	-0.4	0.1	-0.9	1.8
Trunk predicted mass	0.7	3.9	9.5	-0.1	-2.8	-0.9	-1.7	-2.4	-2.2	-2.0	-1.8	-2.3	-1.5	-1.6	-1.1	3.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.8	0.2	-0.5	-0.5	-1.6	1.7	-0.8	-1.1	-2.0	-0.4	-1.9	-0.3	-1.1	0.3
Leg fat mass (right)	0.7	2.9	11.5	2.2	0.8	2.3	0.5	1.4	1.0	1.6	0.5	2.3	3.4	0.6	1.9	-0.3
Long-standing illness, disability or infirmity	0.7	1.0	3.0	-0.6	-1.6	-1.5	-1.0	-0.4	-0.9	-0.9	-1.7	-0.4	-0.5	0.8	-0.9	0.4
Pack years of smoking	0.7	1.1	4.3	1.5	0.1	0.1	0.5	1.1	0.6	0.9	-0.5	2.1	2.0	-0.4	0.7	-0.5
Leg fat mass (left)	0.7	2.8	12.0	2.3	0.7	2.2	0.6	1.3	1.0	1.6	0.3	2.1	3.5	0.4	1.8	-0.2
Depression (Nagel 2018)	0.6	0.9	4.4	2.1	-1.0	0.1	0.3	-0.4	-0.1	0.5	-1.6	1.3	0.8	1.0	0.2	-0.3
Crohns Disease (2017)	0.6	1.4	4.3	1.1	-2.1	0.0	0.4	1.9	1.1	0.8	-1.0	0.9	-0.2	1.8	1.1	-0.8
Ulcerative Colitis (UC)	0.6	1.2	5.9	0.4	-0.8	-0.3	-0.4	2.4	0.3	-0.4	-1.4	0.4	-1.3	2.0	0.1	0.8
Ulcerative Colitis	0.6	0.8	4.8	0.1	-0.0	0.4	0.4	2.2	0.7	-0.2	-0.9	0.6	-0.5	1.9	0.4	0.3
Blood Eosinophil Count	0.6	4.4	7.5	-2.4	-2.3	-2.5	-1.6	2.4	-1.7	-2.6	-2.2	-0.7	-1.7	0.5	-2.5	2.7
Hand grip strength (right)	0.6	1.6	13.0	-0.9	0.4	-0.7	-0.1	-3.6	-0.9	-0.4	0.1	-1.1	-1.8	-0.3	-0.6	0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	4.6	-2.1	0.0	0.1	-0.8	-0.5	-0.8	-0.5	0.0	-0.8	-0.7	-0.9	-1.1	-0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	-1.2	-0.8	-0.6	-0.2	-0.0	-1.2	-1.0	0.2	-0.8	-0.5	-0.9	-1.2	1.1
Impedance of leg (left)	0.6	3.0	10.6	0.1	2.9	0.0	1.9	0.5	1.7	1.6	1.2	2.5	0.2	1.5	1.0	-3.3
Hearing difficulty/problems with background noise	0.6	1.0	2.9	1.0	0.6	0.8	0.4	1.7	0.6	1.2	1.7	1.4	0.9	0.2	0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.3	-0.4	-1.5	-0.2	-0.9	-0.4	-0.6	-0.9	-1.5	-0.4	-0.6	-0.3	-0.7	1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	3.8	-1.1	-0.2	-0.6	-1.6	-0.7	-1.0	-0.5	-0.0	-1.6	-0.1	-2.0	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	10.0	-0.5	-1.7	-0.5	-0.2	-3.2	-0.7	-0.7	-2.0	-1.9	-1.7	-0.5	-0.4	1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.7	0.3	-1.1	-0.7	-1.0	1.6	-0.6	-0.5	1.3	0.4	-0.1	0.0	-0.6	0.7
Neck or shoulder pain in last month	0.6	0.9	2.0	-0.6	-0.3	0.7	-1.4	-1.3	-0.8	-1.1	-0.2	-1.3	-0.7	0.3	-1.3	1.0
Whole body fat mass	0.6	2.4	9.7	2.1	0.9	2.1	0.3	1.2	0.9	1.5	0.5	2.0	3.1	0.1	1.7	-0.2
Alcohol intake frequency.	0.6	1.4	3.7	-0.6	-0.8	-1.3	-1.9	0.3	-1.2	-1.1	-1.3	-1.3	-1.7	-0.2	-1.1	1.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.8	0.7	1.7	-0.2	1.3	-0.3	0.3	0.8	-0.9	1.2	0.1	0.2	1.0	-1.0
Whole body fat-free mass	0.6	3.1	8.3	0.2	-2.6	-0.6	-1.6	-2.4	-1.9	-1.6	-1.7	-2.0	-0.9	-1.6	-0.8	2.9
Eye problems/disorders: Cataract	0.6	0.7	1.9	1.4	-0.0	-0.6	0.9	1.1	0.4	0.7	-1.2	1.1	0.3	-0.4	0.3	-1.0
Back pain experienced in last month	0.6	0.9	6.3	1.3	-1.6	0.4	-0.2	0.6	-0.3	-0.1	-2.5	-0.7	-0.1	0.8	-0.0	0.0
Asthma (self-reported)	0.6	1.2	3.5	-0.7	-1.9	-1.4	-1.1	0.2	-1.2	-1.2	-1.1	-0.8	-0.4	0.7	-1.0	1.1
Whole body water mass	0.6	3.2	8.8	0.2	-2.7	-0.5	-1.6	-2.4	-1.8	-1.6	-1.8	-2.0	-0.9	-1.6	-0.8	3.0
Arm fat mass (left)	0.6	2.4	9.2	2.2	0.5	2.5	0.0	1.2	0.9	1.5	0.6	1.8	3.0	0.3	1.8	0.0
Guilty feelings	0.6	0.9	2.7	0.2	1.1	0.5	0.2	-0.5	1.1	1.3	0.6	1.0	1.4	0.2	1.1	-1.6
Wears glasses or contact lenses	0.6	0.7	3.4	0.8	0.9	0.9	-0.5	0.5	0.4	0.5	0.3	0.9	-0.1	1.8	0.3	-1.3
Medication: Paracetamol	0.6	0.9	3.6	-0.2	0.7	0.6	0.2	0.9	1.1	0.9	1.3	0.7	1.9	-0.3	1.0	-0.9
Illnesses of father: High blood pressure	0.6	0.8	2.8	0.1	1.5	0.7	0.7	-0.6	1.0	0.9	0.6	0.6	0.7	0.5	0.6	-1.7
Number of operations (self-reported)	0.6	0.9	2.8	-1.0	-1.0	-0.7	-1.7	0.1	-0.9	-1.0	-0.4	-0.7	-0.8	0.5	-1.1	1.4
Cholesterol lowering medication	0.6	0.8	3.0	0.9	1.0	1.7	0.1	1.1	0.6	1.0	-0.7	0.5	0.9	0.6	0.9	-0.9
Medication for hormone replacement therapy	0.5	0.6	3.3	-0.4	0.3	0.6	1.1	1.8	1.0	0.6	-0.4	0.3	0.8	-0.4	0.3	-0.4
Severe depression (siblings)	0.5	0.5	1.9	0.1	1.4	0.6	0.2	-0.0	0.6	0.9	1.0	0.6	1.2	-0.5	0.6	-0.6
Impedance of leg (right)	0.5	2.4	8.2	-0.4	2.5	-0.2	1.3	0.7	1.4	1.2	1.1	2.4	-0.3	1.9	0.8	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	1.2	-0.3	0.2	1.0	0.4	0.1	0.7	0.6	1.0	1.4	1.3	0.5	-0.7
Had other major operations	0.5	0.6	2.3	1.0	-0.2	0.9	-1.0	0.4	0.3	0.0	0.2	-0.0	1.0	1.5	0.4	0.9
Alcohol intake versus 10 years previously	0.5	0.7	3.8	1.7	-0.1	0.1	-0.1	2.0	-0.3	0.1	0.1	1.0	0.9	0.7	-0.4	0.5
Father’s age at death	0.5	0.6	2.5	-1.6	0.3	-0.6	0.8	0.8	0.1	-0.1	1.2	-0.4	-1.4	-0.0	-0.4	-0.2
Hair/balding pattern: Pattern 3	0.5	0.8	2.9	-0.2	-1.2	-0.1	-0.7	-0.1	-1.0	-0.8	-0.7	-1.2	-1.7	-0.1	-1.1	0.8
Prospective memory result	0.5	0.6	4.2	-0.4	2.0	0.9	-1.1	0.4	-0.1	-0.2	0.4	-0.0	-0.0	0.6	-0.3	0.5
Arm fat mass (right)	0.5	2.2	8.7	2.1	0.4	2.4	0.1	1.2	0.7	1.2	0.4	1.6	3.0	0.3	1.6	0.3
Medication: Paracetamol	0.5	0.8	3.1	-0.3	0.9	0.8	0.4	0.5	0.8	0.9	1.6	0.5	1.8	0.3	0.9	-0.9
Gout (self-reported)	0.5	0.7	2.1	1.3	-0.5	0.1	-0.0	0.9	0.2	0.3	-0.7	1.5	1.3	0.9	0.7	-0.5
Shortness of breath walking on level ground	0.5	0.6	4.8	1.0	0.3	0.1	0.1	-0.5	-0.4	-0.5	-2.2	0.5	0.4	-0.4	-0.3	1.0
Suffer from ‘nerves’	0.5	0.8	3.3	-0.1	-1.1	-0.5	-0.4	-0.9	-0.5	-0.5	-1.8	-0.5	-1.8	-0.7	-0.5	0.4
Illnesses of father: Heart disease	0.5	0.8	2.7	0.7	1.6	1.1	-0.0	-0.1	0.5	0.5	-0.2	1.2	0.7	1.3	0.8	-0.6
Commuting to job workplace: Walk	0.5	0.5	3.8	-1.0	1.0	-0.5	0.2	-0.3	0.4	-0.0	1.9	-0.1	-0.2	-0.2	0.6	-0.3
Ever taken oral contraceptive pill	0.5	0.6	2.4	-0.4	-1.2	-1.2	-0.1	0.4	-0.6	-0.7	-0.6	-0.0	-0.3	-1.6	-0.4	0.6
Irritability	0.5	0.8	2.8	0.3	0.0	-1.6	-1.4	-1.7	-0.6	-0.6	-0.2	-0.8	-0.1	-0.8	-0.7	0.9
Age started oral contraceptive pill	0.5	0.6	3.1	0.8	0.9	0.6	0.1	-0.1	0.6	0.7	-1.8	0.4	-0.0	-0.6	0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.1	0.4	-1.1	-0.1	-0.5	-1.4	-0.5	-0.3	-1.8	-0.2	-0.1	-0.0	-0.7	0.6
Relative age of first facial hair	0.4	0.8	2.9	-1.4	1.2	0.6	-0.5	-1.7	0.0	-0.4	1.5	-0.2	-0.2	0.5	-0.7	-0.3
Supplements: Zinc	0.4	0.5	1.5	-0.2	-1.2	-0.5	0.2	-0.8	-0.6	-1.1	0.6	-0.2	-0.4	0.3	-0.6	1.0
Diabetes (father)	0.4	0.5	1.3	-1.1	-0.8	-0.7	-0.1	-1.1	-0.5	-0.9	-0.2	-0.4	-0.8	-0.1	-0.4	0.8
Leg fat-free mass (left)	0.4	2.2	6.2	0.4	-2.3	-0.0	-1.5	-2.2	-1.5	-1.2	-1.3	-1.6	-0.3	-1.4	-0.5	2.5
Leg predicted mass (left)	0.4	2.2	6.0	0.4	-2.3	0.0	-1.6	-2.2	-1.5	-1.1	-1.3	-1.6	-0.2	-1.4	-0.5	2.4
Trunk fat mass	0.4	1.9	6.4	2.2	0.9	1.9	0.1	0.6	0.7	1.3	0.2	1.9	2.5	0.2	1.5	-0.1
Mouth/teeth dental problems	0.4	0.6	3.2	0.4	0.3	-0.2	0.6	1.3	0.7	0.5	-0.5	1.8	0.0	0.8	0.4	-0.2
Impedance of arm (right)	0.4	1.7	6.2	-0.2	2.5	0.6	0.3	-0.4	0.9	0.8	1.1	1.6	-0.9	1.6	0.2	-2.5
Arm fat-free mass (right)	0.4	2.2	6.2	0.5	-2.3	-0.5	-1.2	-2.0	-1.4	-1.1	-1.6	-1.5	-0.3	-1.6	-0.4	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-0.7	0.0	0.1	0.2	-0.8	-0.6	-0.6	-1.2	0.1	1.4	-0.2	-0.6	0.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.8	0.6	-1.3	-0.6	-0.4	1.1	-0.4	0.0	-1.3	0.7	1.4	0.7	-0.1	0.5
Number of children fathered	0.4	0.4	1.5	0.1	-0.7	-0.6	0.8	0.3	-0.2	-0.9	-0.1	-0.4	0.4	1.2	-0.5	0.9
Health satisfaction	0.4	0.6	3.8	0.6	-0.7	-0.0	-1.2	0.3	-0.4	-0.4	-2.0	0.3	0.0	-0.4	-0.3	0.6
Qualifications: College or University degree	0.4	1.1	2.5	0.1	-0.8	-0.9	-0.8	-1.6	-1.0	-1.5	-1.6	-1.3	-1.1	0.3	-0.9	0.7
Eye problems/disorders: None of the above	0.4	0.4	1.4	-0.1	0.9	0.8	-0.1	0.1	0.7	0.5	1.2	0.2	0.2	1.2	0.4	-0.2
Emphysema/chronic bronchitis	0.4	0.4	2.4	0.7	0.4	0.6	0.3	-0.4	0.3	0.2	1.6	0.5	1.1	0.2	0.5	0.0
Medication: Omeprazole	0.4	0.4	1.7	0.5	0.4	0.6	-0.2	1.3	0.5	0.4	1.0	0.6	0.6	0.9	0.1	-0.2
Arm predicted mass (right)	0.4	2.1	6.5	0.5	-2.2	-0.5	-1.2	-1.9	-1.4	-1.2	-1.6	-1.6	-0.3	-1.5	-0.3	2.5
Comparative height size at age 10	0.4	2.1	4.1	0.4	-1.0	-1.3	-0.3	-1.7	-2.0	-1.9	-2.0	-1.2	-1.4	-1.3	-1.4	1.9
Age at last live birth	0.4	0.6	4.0	0.7	-0.7	-1.1	-0.0	0.2	0.1	-0.0	-0.3	-0.1	-0.8	2.0	0.2	-0.1
Leg pain on walking	0.4	0.5	2.1	0.8	-0.4	0.6	0.4	1.4	0.3	0.4	-1.0	0.4	1.2	-0.5	0.5	-0.1
Leg fat-free mass (right)	0.4	2.3	6.1	0.5	-2.2	0.0	-1.4	-2.5	-1.4	-1.1	-1.3	-1.8	-0.2	-1.8	-0.5	2.3
Ever had bowel cancer screening	0.4	0.4	1.2	-0.7	-0.9	-0.0	-0.4	-0.6	-0.6	-0.3	0.2	-0.8	-1.1	1.0	-0.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.2	0.9	0.7	0.7	1.1	-0.5	0.3	0.5	-0.3	0.5	0.4	1.8	0.5	-1.1
Osteoporosis (self-reported)	0.4	0.5	2.3	-0.6	-0.3	-1.5	-1.2	-0.2	-0.3	0.2	0.6	-0.1	-1.1	0.1	-0.7	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.6	1.5	-1.1	-1.2	-0.6	-0.2	0.9	-0.5	-0.8	-0.2	-0.8	-0.2	-0.8	-0.7	0.8
Leg predicted mass (right)	0.4	2.2	5.8	0.6	-2.2	0.1	-1.3	-2.4	-1.4	-1.1	-1.3	-1.7	-0.2	-1.7	-0.4	2.3
Number of self-reported non-cancer illnesses	0.4	0.8	3.0	-0.1	0.5	-0.5	-1.7	1.3	-0.6	-1.0	-1.5	0.7	0.4	0.2	-0.3	0.7
Miserableness	0.4	0.6	1.4	0.5	0.6	0.5	0.3	0.5	0.9	0.8	-0.1	0.9	1.2	1.0	0.7	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.6	1.3	0.3	0.5	0.8	0.6	0.4	0.1	-0.9	0.3	-0.0	1.2	0.0	0.3
Commuting to job workplace: Cycle	0.4	0.5	3.3	0.3	0.1	0.1	1.8	-0.9	0.6	0.6	0.3	0.1	0.7	0.0	0.5	-0.7
Impedance of whole body	0.4	2.0	8.2	-0.3	2.7	-0.0	0.9	-0.5	1.0	1.0	0.9	1.9	-0.7	1.5	0.3	-2.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	0.9	0.4	0.9	1.2	-0.1	0.4	0.3	-1.0	0.6	1.1	1.0	0.4	-0.3
Worry (Nagel 2018)	0.3	0.5	2.9	-0.5	0.2	0.2	0.3	-1.7	-0.1	-0.1	-1.0	-1.0	-1.2	-0.4	-0.4	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	2.0	-0.2	-0.7	1.4	-0.5	0.5	-0.1	0.1	-0.7	-1.1	-0.3	-0.5	0.1	0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	2.5	0.2	-0.3	0.9	-0.5	0.9	0.2	0.5	-0.4	-1.6	-0.7	-0.7	0.4	0.3
Primary Biliary Cirrhosis	0.3	0.5	1.9	0.1	0.1	0.4	0.0	0.3	-0.8	-1.4	-0.7	-0.3	-0.4	0.9	-0.8	1.0
Blood White Count	0.3	2.0	9.1	1.5	0.9	0.8	-0.5	2.3	0.6	0.1	0.0	1.4	3.0	1.8	0.1	1.2
Hypothyroidism (self reported)	0.3	0.6	2.4	0.3	0.2	-0.1	-1.2	0.7	-0.7	-0.9	-1.6	-0.5	-1.4	-0.2	-0.9	-0.1
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	-0.5	-0.3	-0.1	-1.0	-0.4	0.1	-0.4	-1.0	-1.0	-0.3	0.5	-0.1	0.6
Age when periods started (menarche)	0.3	0.6	3.2	0.7	-0.6	-0.6	0.7	0.2	-0.0	-0.2	0.1	1.2	-1.1	1.8	-0.3	0.3
Medication: Levothyroxine sodium	0.3	0.5	3.2	0.7	0.6	0.2	-0.6	1.8	0.3	-0.0	-1.1	0.0	-0.8	0.2	-0.1	-0.6
High blood pressure (mother)	0.3	0.4	2.5	-0.1	-0.1	0.5	0.6	0.8	0.1	0.0	-1.6	0.8	0.1	0.5	0.0	-0.5
Nervous feelings	0.3	0.6	2.0	-0.7	0.1	-1.0	-0.4	-1.3	-0.0	-0.1	-0.6	-1.0	-1.4	-0.3	-0.7	-0.4
Hair/balding pattern: Pattern 2	0.3	0.3	1.7	-0.9	-0.1	-0.5	0.2	-0.4	-0.4	-0.5	-1.3	-0.1	-0.1	-0.1	-1.0	0.1
Financial difficulties in last 2 years	0.3	0.4	1.5	-0.1	-1.0	-0.6	-0.7	-0.2	-0.4	-0.3	1.2	-0.6	0.5	-0.3	-0.6	0.4
Heart attack	0.3	0.3	1.1	0.6	-0.1	-0.3	0.2	-1.0	-0.1	0.3	1.1	-0.5	0.5	0.9	0.2	-0.6
Pain all over the body in last month	0.3	0.3	0.8	-0.7	0.1	-0.3	0.3	-0.6	-0.4	-0.4	0.3	-0.9	0.0	-0.5	-0.7	0.7
Time employed in main current job	0.3	0.4	1.0	0.5	-0.2	0.2	0.6	0.8	0.4	0.4	-1.0	0.5	0.7	-0.4	0.6	-0.8
Falls in the last year	0.3	0.4	1.5	-0.7	-0.0	0.5	0.3	0.1	-0.1	-0.0	1.2	-0.8	-0.6	1.2	-0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.8	0.2	-1.6	0.3	-0.1	-1.9	0.1	-0.0	-1.6	-0.9	-1.4	0.2	0.2	0.8
Asthma	0.3	0.6	2.0	-0.2	-1.4	-1.1	-0.6	0.4	-0.9	-0.9	-0.9	-0.6	0.0	1.0	-0.6	0.8
Lung cancer (father)	0.3	0.3	0.7	-0.8	-0.1	-0.1	-0.1	0.4	-0.7	-0.7	-0.1	-0.8	-0.3	-0.6	-0.7	0.8
Impedance of arm (left)	0.3	1.2	5.6	-0.5	2.2	0.4	0.3	-1.1	0.4	0.4	0.6	1.1	-1.1	0.9	-0.1	-2.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	1.0	0.4	1.1	1.1	-0.0	0.4	0.4	0.6	-0.7	-0.1	0.5	0.4	-0.4
Birth weight	0.3	0.7	5.6	0.0	0.1	-0.7	0.0	-2.4	-0.7	-0.3	-0.9	-0.7	-0.7	0.6	-0.3	0.3
Comparative body size at age 10	0.3	0.9	2.2	-0.6	-0.2	-0.5	0.4	-0.4	-1.5	-1.3	1.3	-1.5	-0.8	-0.7	-1.1	0.8
Age at first live birth	0.3	0.5	2.6	0.4	-1.1	-0.7	0.1	-0.8	0.1	-0.3	-0.4	-1.1	-1.6	0.6	0.0	0.1
Overall health rating	0.3	0.6	2.6	0.7	-0.3	1.1	0.5	1.3	0.5	0.6	-0.2	0.3	1.6	0.7	0.4	0.1
Family relationship satisfaction	0.3	0.3	1.7	-0.1	-0.6	0.0	0.2	0.4	-0.3	-0.5	1.3	-0.6	0.4	0.5	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.3	0.9	0.1	0.4	1.2	-1.1	0.2	0.1	0.7	-0.2	0.2	1.5	0.3	-0.6
Loneliness, isolation	0.3	0.4	1.9	0.1	-0.0	0.5	0.3	-0.3	0.3	0.4	1.1	0.4	0.9	1.4	0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.3	-0.5	1.1	-0.4	0.2	-0.4	0.1	0.1	0.8	0.7	0.9	0.3	0.6	-0.7
Friendships satisfaction	0.3	0.4	1.8	0.5	-0.3	0.7	1.0	0.6	0.1	0.1	0.9	-0.7	-0.1	1.3	0.2	-0.0
Osteoarthritis (self-reported)	0.3	0.4	2.6	1.0	-1.0	-0.5	-0.7	0.7	0.2	-0.0	-1.6	0.0	0.2	0.2	-0.1	0.1
Medication: Gliclazide	0.3	0.3	0.7	0.8	0.3	0.5	0.4	0.8	0.6	0.7	-0.6	0.1	0.8	-0.0	0.5	-0.7
Basal metabolic rate	0.3	1.9	5.8	0.6	-2.0	-0.0	-1.3	-2.0	-1.4	-1.1	-1.3	-1.3	-0.2	-1.3	-0.3	2.4
Arm fat-free mass (left)	0.3	1.8	6.2	0.7	-2.1	-0.3	-1.2	-1.6	-1.3	-1.0	-1.6	-1.1	-0.2	-1.0	-0.3	2.5
Ever depressed for a whole week	0.3	0.4	0.9	-0.4	-0.1	0.5	-0.3	-0.6	-0.7	-0.6	-0.9	-0.1	-0.6	-0.6	-0.7	0.9
Arm predicted mass (left)	0.3	1.6	6.1	0.7	-2.0	-0.2	-1.0	-1.5	-1.2	-0.9	-1.4	-1.0	0.0	-1.0	-0.2	2.5
Bipolar Disorder (2018)	0.2	0.4	1.4	-0.5	-0.5	-0.7	0.5	-0.5	0.3	-0.2	0.9	0.6	1.2	0.7	-0.0	0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	2.6	-0.9	-0.6	-0.7	0.5	-1.6	-0.1	-0.3	0.2	0.2	1.0	0.5	-0.2	0.2
Neuroticism (Nagel 2018)	0.2	0.5	2.7	0.6	0.7	0.4	0.7	-1.6	0.3	0.4	-0.8	0.4	0.2	0.3	0.3	-0.7
Schizophrenia (2018)	0.2	0.3	2.7	-0.7	-0.3	-0.2	0.3	-1.7	-0.3	-0.2	-0.5	-0.2	0.3	0.0	-0.3	-0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.8	-0.0	-0.6	-0.2	0.2	0.3	0.7	0.5	-0.7	-0.2	-0.8	0.5	-0.1
Prostate Cancer	0.2	0.3	1.7	-0.3	-1.3	0.1	-0.2	0.9	-0.1	0.5	0.3	0.1	0.1	0.1	0.2	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	2.1	0.2	-0.7	0.0	-0.1	-1.5	-0.2	0.1	0.3	0.1	0.6	-0.6	-0.0	0.0
Neuroticism (2016)	0.2	0.3	2.1	-1.4	-0.5	-0.4	-0.1	-0.4	0.2	-0.3	-0.2	0.1	0.4	0.7	-0.5	0.1
Neuroticism	0.2	0.4	3.2	-0.5	-0.1	-0.6	-0.0	-1.8	-0.1	-0.0	0.5	-1.0	-0.6	0.1	-0.5	-0.1
Tanning	0.2	2.7	5.6	-1.4	-2.1	-1.2	-1.5	-1.0	-2.4	-2.0	1.1	-1.8	-2.0	-0.3	-1.7	1.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.3	-0.3	-0.5	0.8	0.3	1.1	0.5	0.5	-0.4	-0.1	0.5	0.2	0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.4	0.0	0.3	0.4	0.9	0.6	-0.0	-0.2	-0.4	-0.2	1.2	0.0	-0.2	-0.1
Average weekly fortified wine intake	0.2	0.3	1.5	0.3	-0.2	-0.4	-0.3	-1.2	-0.4	-0.6	-0.0	-0.5	-0.6	-0.1	-0.6	0.4
Fed-up feelings	0.2	0.3	1.0	0.2	-1.0	-0.5	0.3	0.0	-0.0	0.0	-0.9	-0.6	1.0	-0.8	0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	0.7	-0.0	0.7	-0.1	-0.6	-0.4	0.1	-1.0	-0.0	-0.0	0.7	-0.3	-0.2
Medication: Ramipril	0.2	0.3	1.1	0.5	-0.6	-0.7	0.0	0.1	-0.3	-0.0	1.1	-1.0	-0.1	-0.4	-0.5	-0.1
Weight	0.2	1.0	3.2	1.8	-0.0	1.6	-0.4	-0.4	0.1	0.6	-0.4	0.7	1.8	-0.3	1.1	0.8
Hip circumference	0.2	0.9	3.3	1.6	0.1	1.7	-0.6	-0.2	0.2	0.7	-0.0	0.6	1.8	-0.4	0.9	0.5
Tense / ‘highly strung’	0.2	0.4	0.9	0.7	0.9	0.6	0.9	-0.9	0.5	0.6	-0.5	0.4	0.6	0.1	0.2	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	1.0	-0.0	-0.7	0.0	0.4	1.0	-0.2	-0.2	-0.1	0.2	0.7	0.6	0.1	0.1
Migraine (self-reported)	0.2	0.3	1.5	-0.3	-0.4	-0.4	-1.2	0.3	-0.1	-0.3	-0.1	-0.5	-0.8	-0.3	0.1	0.5
Medication: Allopurinol	0.2	0.3	1.4	-0.2	-1.0	-0.7	-1.2	0.2	-0.7	-0.5	0.1	-0.2	0.3	-0.0	-0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	0.9	0.1	0.4	0.8	0.3	-0.2	-0.5	-0.5	0.1	-0.1	0.0	-0.7	0.5
Knee pain experienced in last month	0.2	0.4	1.6	-0.3	-0.3	-1.0	-0.8	-0.6	-0.1	0.0	-1.2	-0.7	0.4	-0.4	-0.4	0.3
Illnesses of siblings: Diabetes	0.2	0.2	1.1	-1.0	0.5	0.2	-0.1	0.4	-0.1	-0.2	-0.7	-0.3	-0.0	-0.4	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	0.6	-0.9	0.1	-0.2	-0.7	0.7	0.8	-0.8	-0.8	-0.7	0.1	0.8	-0.9
Average weekly champagne plus white wine intake	0.2	0.2	1.3	0.3	0.0	-0.3	1.1	-0.5	0.2	0.2	0.7	-0.4	0.4	-0.1	-0.0	-0.3
Unable to work because of sickness or disability	0.2	0.3	2.3	-0.2	-0.1	-0.4	0.0	1.5	-0.5	-0.5	-0.3	-0.6	-0.2	0.6	-0.5	0.3
Pain experienced in last month	0.2	0.3	1.4	0.0	-0.7	-0.9	0.5	0.7	0.0	-0.3	-0.3	0.3	-0.6	-1.2	-0.1	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	1.8	0.4	0.0	-0.0	0.2	-0.3	0.3	0.5	-0.1	0.5	0.0	1.4	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	0.7	-0.3	-0.2	0.1	-1.0	-0.0	0.3	0.8	-0.5	0.3	1.0	0.2	-0.6
Schizophrenia (2014)	0.1	0.2	0.6	-0.1	0.3	0.3	0.5	-0.6	0.4	0.4	-0.2	0.6	0.8	0.6	0.3	-0.4
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.3	0.3	-0.1	0.1	-0.1	0.0	0.4	0.3	0.5	-0.4	0.5	-0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.4	0.5	0.6	0.6	0.0	0.6	-0.1	-0.2	0.2	0.7	-0.3	0.0	0.1	0.4
Number of incorrect matches in round	0.1	0.2	0.7	0.6	0.1	0.2	0.2	0.1	0.3	0.6	0.8	0.8	-0.1	0.7	0.3	-0.6
Alcohol usually taken with meals	0.1	0.1	0.5	0.0	0.1	0.3	0.4	0.4	0.1	-0.2	-0.5	0.5	0.0	0.7	-0.3	0.3
Qualifications: None of the above	0.1	0.3	1.5	0.3	0.5	0.3	0.5	1.2	0.1	0.2	1.0	0.8	0.4	-0.1	0.1	-0.1
Neuroticism score	0.1	0.1	1.1	0.0	0.1	-0.2	-0.1	-1.0	0.2	0.3	-0.2	-0.3	0.1	0.4	-0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.3	0.3	0.6	-0.3	0.1	0.1	0.2	-0.3	-0.2	0.6	0.5	-0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.0	0.7	1.0	0.6	0.1	-0.5	-0.0	0.0	0.3	-0.8	-0.2	-0.6	0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.9	0.8	-0.7	0.3	0.4	0.3	-0.1	-0.2	0.3	-0.2	0.9	0.2	0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	1.1	-0.5	0.1	0.5	1.1	-0.2	0.1	-0.1	-0.4	0.5	0.6	0.2	-0.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.4	0.5	-0.2	-0.3	-0.2	0.6	0.4	0.3	0.2	0.5	0.6	0.4	-0.4
Headache pain in last month	0.1	0.2	1.2	-0.5	0.3	-0.3	-0.5	-0.4	-0.7	-0.4	0.6	-0.2	0.2	1.1	-0.4	0.2
Medication: Ibuprofen	0.1	0.2	0.6	0.4	-0.8	0.0	-0.2	0.2	-0.4	-0.6	0.5	-0.4	0.5	-0.3	-0.2	0.2
Had major operations	0.1	0.2	0.4	-0.5	0.2	-0.3	0.5	0.6	-0.5	-0.4	0.2	-0.3	-0.5	-0.0	-0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.7	0.1	-0.8	0.3	0.0	0.4	-0.2	-0.1	-0.8	-0.1	0.1	0.6	-0.4	0.3
Supplements: Vitamin C	0.1	0.1	0.6	0.2	0.8	0.5	-0.0	0.0	0.2	-0.0	-0.1	0.2	-0.2	-0.1	0.5	-0.2
Mood swings	0.1	0.2	1.1	-0.7	-0.2	0.1	0.7	-0.6	0.1	-0.3	-0.6	-0.2	1.0	-0.0	-0.0	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.1	-0.5	0.0	-0.6	0.6	0.0	-0.0	0.2	0.1	-0.1	0.4	-0.1	0.1
Hair Pigment	0.0	1.4	7.2	0.2	-0.7	0.4	0.2	-1.5	-0.7	-0.9	-2.7	-1.2	0.1	0.1	-1.0	2.1

Hub : Genes

ATP5J2

Models

Trait associations