Hub : Genes

ATP5J2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1330 0.0460 1.0e-04 0.058 NA 0.072 NA 0.055 1.7e-05 NA 1.7e-06 NA 2.8e-05
2 GTEx Artery Coronary 0.2670 0.1240 6.0e-03 0.064 NA 0.000 NA 0.037 3.5e-03 NA 3.3e-01 NA 2.1e-02
3 GTEx Artery Tibial 0.0945 0.0474 5.3e-03 0.050 NA 0.066 NA 0.056 8.8e-05 NA 7.5e-06 NA 3.1e-05
4 GTEx Brain Cerebellum 0.2740 0.0900 1.1e-03 0.030 NA -0.006 NA 0.001 4.5e-02 NA 5.3e-01 NA 3.0e-01
5 GTEx Breast Mammary Tissue (Female) 0.1316 0.0905 3.2e-02 0.042 NA 0.103 NA 0.065 2.2e-02 NA 5.5e-04 NA 5.3e-03
6 GTEx Cells Transformed fibroblasts 0.1560 0.0600 3.7e-03 0.043 NA 0.040 NA 0.042 3.6e-04 NA 5.1e-04 NA 4.1e-04
7 GTEx Esophagus Muscularis 0.1040 0.0510 4.0e-03 0.050 NA 0.043 NA 0.059 5.4e-04 NA 1.3e-03 NA 1.8e-04
8 GTEx Heart Left Ventricle 0.2932 0.1057 1.9e-03 0.037 NA 0.050 NA 0.041 4.8e-03 NA 1.2e-03 NA 3.1e-03
9 GTEx Skin Sun Exposed Lower leg 0.1610 0.0520 1.2e-05 0.094 NA 0.098 NA 0.093 3.4e-08 NA 1.6e-08 NA 4.0e-08
10 GTEx Testis 0.2090 0.0650 1.4e-06 0.134 NA 0.144 NA 0.190 1.6e-06 NA 6.4e-07 NA 7.5e-09
11 GTEx Thyroid 0.1890 0.0590 3.1e-04 0.003 NA 0.055 NA 0.032 1.6e-01 NA 5.2e-05 NA 1.6e-03
12 METSIM Adipose 0.0763 0.0271 6.9e-08 0.077 0.053 0.070 0.069 0.073 1.3e-11 1.8e-08 1.1e-10 1.4e-10 5.1e-11
13 YFS Blood 0.0219 0.0085 2.2e-05 0.018 0.007 0.005 0.011 0.011 1.4e-06 1.4e-03 5.1e-03 8.5e-05 9.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.2 0.4 1.4 -0.5 -0.5 -0.7 0.5 -0.5 0.3 -0.2 0.9 0.6 1.2 0.7 -0.0 0.5
Bipolar Disorder or Schizophrenia 0.2 0.5 2.6 -0.9 -0.6 -0.7 0.5 -1.6 -0.1 -0.3 0.2 0.2 1.0 0.5 -0.2 0.2
Depressed Affect (Nagel 2018) 0.3 0.6 1.5 0.9 0.4 0.9 1.2 -0.1 0.4 0.3 -1.0 0.6 1.1 1.0 0.4 -0.3
Depression (Nagel 2018) 0.6 0.9 4.4 2.1 -1.0 0.1 0.3 -0.4 -0.1 0.5 -1.6 1.3 0.8 1.0 0.2 -0.3
Intelligence (Savage-Jansen 2018) 1.2 3.7 9.9 3.1 1.2 2.2 1.6 0.7 2.3 1.9 0.2 1.5 1.7 2.4 2.3 -1.9
Neuroticism (Nagel 2018) 0.2 0.5 2.7 0.6 0.7 0.4 0.7 -1.6 0.3 0.4 -0.8 0.4 0.2 0.3 0.3 -0.7
Schizophrenia (2018) 0.2 0.3 2.7 -0.7 -0.3 -0.2 0.3 -1.7 -0.3 -0.2 -0.5 -0.2 0.3 0.0 -0.3 -0.1
Schizophrenia vs Biploar Disorder 1.1 1.4 5.0 -0.6 -0.2 -0.5 -1.8 -0.8 -1.1 -1.0 -0.8 -1.5 -2.2 -0.9 -1.4 1.2
Worry (Nagel 2018) 0.3 0.5 2.9 -0.5 0.2 0.2 0.3 -1.7 -0.1 -0.1 -1.0 -1.0 -1.2 -0.4 -0.4 -0.2
Alzheimer’s Disease (in mother) 0.3 0.4 2.0 -0.2 -0.7 1.4 -0.5 0.5 -0.1 0.1 -0.7 -1.1 -0.3 -0.5 0.1 0.6
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.8 -0.0 -0.6 -0.2 0.2 0.3 0.7 0.5 -0.7 -0.2 -0.8 0.5 -0.1
Alzheimer’s Disease (including proxy) 0.3 0.5 2.5 0.2 -0.3 0.9 -0.5 0.9 0.2 0.5 -0.4 -1.6 -0.7 -0.7 0.4 0.3
Crohns Disease (2017) 0.6 1.4 4.3 1.1 -2.1 0.0 0.4 1.9 1.1 0.8 -1.0 0.9 -0.2 1.8 1.1 -0.8
Irritable Bowel Disease (IBD) 0.7 1.7 6.7 0.9 -1.8 -0.1 0.1 2.6 0.8 0.3 -1.3 1.0 -0.9 2.5 0.8 -0.1
Ulcerative Colitis (UC) 0.6 1.2 5.9 0.4 -0.8 -0.3 -0.4 2.4 0.3 -0.4 -1.4 0.4 -1.3 2.0 0.1 0.8
Major Depression (MDD) 1.8 2.1 4.8 0.7 1.3 2.0 1.4 0.7 1.4 1.3 0.9 2.2 1.5 2.2 1.1 -1.4
Reaction Time 1.5 2.8 6.4 1.4 0.6 1.0 1.6 2.0 2.0 1.9 0.3 1.8 2.5 -0.9 2.2 -1.9
Verbal and Numeric Reasoning (VNR) 0.8 2.0 5.7 2.0 0.7 1.4 1.2 0.9 1.5 1.1 1.0 0.7 1.1 2.4 1.7 -1.3
Breast Cancer 1.4 3.4 9.4 1.0 2.7 1.6 1.5 0.0 1.6 1.8 3.1 2.0 1.0 0.8 2.1 -2.3
Ovarian Cancer 1.2 1.7 3.5 1.2 1.3 1.6 1.0 1.0 1.0 1.1 0.9 1.9 1.6 1.4 1.2 -1.0
Prostate Cancer 0.2 0.3 1.7 -0.3 -1.3 0.1 -0.2 0.9 -0.1 0.5 0.3 0.1 0.1 0.1 0.2 -0.5
Age at First Birth 2.3 3.4 7.5 -1.1 -0.9 -2.2 -2.3 -1.9 -2.1 -1.9 -1.1 -2.1 -2.7 -1.1 -2.2 1.3
Bipolar Disorder (2011) 0.9 0.9 2.6 0.4 -0.3 0.2 1.6 -0.1 1.0 0.8 -0.5 1.3 1.6 0.9 0.9 -0.7
Body Mass Index (BMI) (2010) 0.2 0.3 2.1 0.2 -0.7 0.0 -0.1 -1.5 -0.2 0.1 0.3 0.1 0.6 -0.6 -0.0 0.0
Coronary Artery Disease (CAD) 1.0 1.2 3.1 0.5 1.8 0.6 0.6 -0.4 0.8 1.2 0.4 1.4 1.1 1.6 0.8 -1.7
Crohns Disease (2012) 0.8 1.3 4.8 1.1 -0.9 0.7 0.5 1.8 1.1 0.7 -1.0 1.5 -0.1 2.2 1.2 -0.7
Mean Putamen Volume 2.0 2.3 7.1 0.8 2.2 1.4 0.8 -0.7 1.1 1.7 2.7 0.7 1.7 1.4 1.6 -1.6
Fasting Glucose 1.4 1.7 4.6 -0.5 -0.6 -1.2 -1.2 -2.1 -1.5 -1.3 -0.9 -1.1 -1.2 -1.6 -1.6 1.3
HbA1C 11.3 12.6 19.5 -2.5 -4.2 -4.3 -3.2 -2.5 -4.1 -4.3 -2.6 -2.7 -3.6 -2.5 -4.4 4.1
HDL Cholesterol 1.1 1.8 3.3 -1.7 -0.8 -1.8 -0.9 -1.3 -1.2 -1.3 -0.3 -1.8 -1.8 -0.7 -1.6 1.4
LDL Cholesterol 0.8 1.2 2.3 -0.9 -0.9 -1.4 -1.5 -1.5 -0.9 -1.1 -1.1 -0.5 -1.2 -0.4 -1.1 1.2
Lupus 1.7 2.5 4.6 0.9 2.1 1.8 1.3 1.5 2.1 1.8 1.1 1.2 1.5 1.1 2.1 -1.6
Neuroticism (2016) 0.2 0.3 2.1 -1.4 -0.5 -0.4 -0.1 -0.4 0.2 -0.3 -0.2 0.1 0.4 0.7 -0.5 0.1
Primary Biliary Cirrhosis 0.3 0.5 1.9 0.1 0.1 0.4 0.0 0.3 -0.8 -1.4 -0.7 -0.3 -0.4 0.9 -0.8 1.0
Rheumatoid Arthritis 5.2 7.2 11.3 -2.8 -2.7 -2.4 -2.2 -2.1 -2.9 -3.1 -2.1 -3.1 -3.4 -2.0 -3.1 2.7
Schizophrenia (2014) 0.1 0.2 0.6 -0.1 0.3 0.3 0.5 -0.6 0.4 0.4 -0.2 0.6 0.8 0.6 0.3 -0.4
Triglycerides 1.9 3.1 5.1 2.0 1.3 1.7 1.4 1.5 2.0 1.9 0.9 2.2 2.2 1.1 2.1 -2.1
Type 2 Diabetes (T2D) (2012) 0.7 0.8 8.3 0.3 0.3 0.3 -0.9 -0.1 0.0 -0.2 -2.9 -0.0 -0.3 0.8 -0.1 0.3
Ulcerative Colitis 0.6 0.8 4.8 0.1 -0.0 0.4 0.4 2.2 0.7 -0.2 -0.9 0.6 -0.5 1.9 0.4 0.3
Blood Eosinophil Count 0.6 4.4 7.5 -2.4 -2.3 -2.5 -1.6 2.4 -1.7 -2.6 -2.2 -0.7 -1.7 0.5 -2.5 2.7
Blood Platelet Count 1.2 13.5 28.7 4.0 0.9 2.3 4.4 5.4 4.3 4.2 3.1 3.0 4.2 4.0 3.8 -1.4
Blood Red Count 2.8 26.7 49.6 5.1 4.5 3.9 -1.7 4.4 7.0 6.5 -3.1 6.3 5.1 3.8 6.3 -6.5
Blood White Count 0.3 2.0 9.1 1.5 0.9 0.8 -0.5 2.3 0.6 0.1 0.0 1.4 3.0 1.8 0.1 1.2
Heel T-Score 1.1 8.8 21.8 3.0 3.4 3.7 2.4 0.3 2.8 2.8 -1.5 3.2 4.7 2.3 3.1 -3.2
BMI 0.9 5.4 23.6 3.1 0.9 2.7 1.0 2.8 1.5 2.2 1.3 2.2 4.9 1.1 2.4 -0.6
Height 0.9 17.6 75.7 -2.5 -2.5 -3.7 -2.8 -8.7 -3.8 -3.2 -3.8 -3.4 -5.9 -3.8 -3.1 2.9
Waist Hip Ratio (WHR) 1.0 4.5 12.4 1.7 1.5 1.4 2.2 2.9 1.3 1.9 3.5 2.6 2.7 0.1 2.0 -1.6
Systolic Blood Pressure 1.5 7.6 12.5 2.0 3.4 2.4 2.1 1.4 3.3 3.3 0.6 3.5 2.9 2.9 2.9 -3.4
Smoking Status 2.8 6.7 17.1 1.6 1.2 2.0 2.3 3.6 2.4 2.0 4.0 2.8 4.1 2.0 2.5 -1.1
Allergy or Eczema 3.6 9.5 19.1 -2.9 -2.2 -3.2 -2.9 -0.4 -3.4 -3.9 -4.4 -2.6 -3.5 -2.0 -3.6 3.1
Cardiovascular Disease 2.8 9.2 19.7 2.7 3.5 2.7 2.4 1.5 2.7 3.5 1.9 3.4 4.4 2.0 3.3 -3.8
Hypothyroidism (self reported) 0.3 0.6 2.4 0.3 0.2 -0.1 -1.2 0.7 -0.7 -0.9 -1.6 -0.5 -1.4 -0.2 -0.9 -0.1
Respiratory disease 1.1 2.5 5.2 -1.6 -2.1 -2.0 -0.9 0.1 -2.3 -2.1 -1.4 -1.1 -0.8 0.2 -1.9 1.9
Type 2 Diabetes (T2D) (2018) 2.2 4.2 11.4 3.0 1.8 2.2 1.6 2.5 1.5 1.5 -1.0 2.2 3.4 -0.5 2.1 -1.5
Lung FEV1/FVC ratio 2.5 12.8 31.2 3.3 3.5 5.6 2.4 3.6 4.6 4.2 -0.2 2.7 3.0 3.3 4.3 -3.0
Lung FVC 1.5 7.8 17.5 -1.2 -4.2 -2.9 -2.5 -4.1 -3.0 -2.8 -1.3 -2.5 -3.4 -1.6 -2.6 2.5
Neuroticism 0.2 0.4 3.2 -0.5 -0.1 -0.6 -0.0 -1.8 -0.1 -0.0 0.5 -1.0 -0.6 0.1 -0.5 -0.1
Chronotype (morning person) 1.5 3.6 11.7 -2.9 -0.7 -0.5 -0.7 -3.4 -2.2 -2.1 -0.4 -1.8 -2.7 -0.5 -1.8 1.3
Hair Pigment 0.0 1.4 7.2 0.2 -0.7 0.4 0.2 -1.5 -0.7 -0.9 -2.7 -1.2 0.1 0.1 -1.0 2.1
Tanning 0.2 2.7 5.6 -1.4 -2.1 -1.2 -1.5 -1.0 -2.4 -2.0 1.1 -1.8 -2.0 -0.3 -1.7 1.9
Hand grip strength (left) 0.9 2.3 13.9 -1.0 -0.2 -1.1 -0.9 -3.7 -1.2 -1.0 0.2 -1.4 -2.7 0.2 -1.0 0.6
Number of treatments/medications taken 1.3 2.4 6.9 0.8 1.5 1.0 0.3 2.6 1.6 1.6 -0.2 1.8 2.1 1.5 1.1 -2.0
Average weekly spirits intake 0.7 0.9 3.8 -0.7 -1.8 -0.7 -1.2 0.5 -0.6 -0.4 -0.3 -0.2 0.4 -1.9 -0.4 1.0
Sensitivity / hurt feelings 0.1 0.1 0.2 -0.3 0.3 -0.1 0.1 -0.1 0.0 0.4 0.3 0.5 -0.4 0.5 -0.2 -0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 3.1 0.4 -1.1 -0.1 -0.5 -1.4 -0.5 -0.3 -1.8 -0.2 -0.1 -0.0 -0.7 0.6
Hearing difficulty/problems: Yes 0.7 1.0 2.3 0.8 1.0 1.2 0.4 1.5 0.8 1.2 0.6 1.3 1.0 1.4 0.8 -0.6
Relative age of first facial hair 0.4 0.8 2.9 -1.4 1.2 0.6 -0.5 -1.7 0.0 -0.4 1.5 -0.2 -0.2 0.5 -0.7 -0.3
Other serious medical condition/disability diagnosed by doctor 1.0 1.4 3.4 -1.1 -1.2 -1.3 -0.8 -0.1 -1.2 -1.4 -0.9 -1.8 -1.0 -0.4 -1.3 1.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.3 -0.3 -0.5 0.8 0.3 1.1 0.5 0.5 -0.4 -0.1 0.5 0.2 0.3 -0.6
Ever had hysterectomy (womb removed) 0.3 0.3 1.0 -0.5 -0.3 -0.1 -1.0 -0.4 0.1 -0.4 -1.0 -1.0 -0.3 0.5 -0.1 0.6
Systolic blood pressure, automated reading 2.6 7.5 12.5 2.8 3.4 3.1 1.8 2.0 3.0 3.1 -0.6 3.5 3.0 2.5 2.4 -2.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.4 0.0 0.3 0.4 0.9 0.6 -0.0 -0.2 -0.4 -0.2 1.2 0.0 -0.2 -0.1
Angina 0.9 1.1 3.4 0.5 1.3 0.7 1.3 -0.2 0.8 1.0 1.8 0.3 1.8 0.4 0.9 -1.2
Medication for hormone replacement therapy 0.5 0.6 3.3 -0.4 0.3 0.6 1.1 1.8 1.0 0.6 -0.4 0.3 0.8 -0.4 0.3 -0.4
Vitamin and mineral supplements 3.5 4.7 10.0 2.8 1.1 1.5 1.6 2.3 2.2 2.8 0.0 3.2 2.1 1.3 2.5 -2.6
Supplements: Zinc 0.4 0.5 1.5 -0.2 -1.2 -0.5 0.2 -0.8 -0.6 -1.1 0.6 -0.2 -0.4 0.3 -0.6 1.0
Medication: Co-codamol 0.9 1.0 2.6 0.5 -1.1 -1.6 -1.0 -0.4 -0.7 -0.8 -0.9 -1.1 -0.6 -1.4 -1.0 1.0
Medication: Metformin 0.7 1.0 3.8 2.0 0.4 1.0 0.4 1.0 0.5 0.6 -1.1 0.7 1.9 -0.1 1.1 -0.4
Diabetes (father) 0.4 0.5 1.3 -1.1 -0.8 -0.7 -0.1 -1.1 -0.5 -0.9 -0.2 -0.4 -0.8 -0.1 -0.4 0.8
Diabetes (mother) 1.5 1.9 7.8 -0.2 1.6 0.5 1.4 2.8 0.7 1.2 1.6 1.5 2.0 -0.0 1.0 -1.0
Severe depression (siblings) 0.5 0.5 1.9 0.1 1.4 0.6 0.2 -0.0 0.6 0.9 1.0 0.6 1.2 -0.5 0.6 -0.6
Pack years adult smoking proportion 1.0 1.5 5.8 1.5 0.4 0.5 0.8 1.2 0.9 1.2 -0.0 2.4 2.3 -0.1 1.1 -0.9
Impedance of leg (right) 0.5 2.4 8.2 -0.4 2.5 -0.2 1.3 0.7 1.4 1.2 1.1 2.4 -0.3 1.9 0.8 -2.9
Leg fat-free mass (left) 0.4 2.2 6.2 0.4 -2.3 -0.0 -1.5 -2.2 -1.5 -1.2 -1.3 -1.6 -0.3 -1.4 -0.5 2.5
Trunk fat percentage 0.9 3.6 9.4 2.4 1.9 2.5 0.5 1.3 1.4 2.0 0.8 2.8 3.1 0.7 2.0 -1.2
Hand grip strength (right) 0.6 1.6 13.0 -0.9 0.4 -0.7 -0.1 -3.6 -0.9 -0.4 0.1 -1.1 -1.8 -0.3 -0.6 0.1
Townsend deprivation index at recruitment 0.7 0.9 4.3 0.3 0.7 0.4 0.1 1.3 0.4 0.4 2.1 1.3 1.4 -0.8 0.9 -0.4
Current tobacco smoking 0.8 1.4 7.1 0.1 -0.4 0.3 0.3 2.7 0.5 0.6 2.3 1.2 1.2 1.1 0.5 -0.3
Average weekly fortified wine intake 0.2 0.3 1.5 0.3 -0.2 -0.4 -0.3 -1.2 -0.4 -0.6 -0.0 -0.5 -0.6 -0.1 -0.6 0.4
Maternal smoking around birth 0.7 1.0 3.9 -0.2 -0.4 -0.8 -0.0 0.5 -0.8 -0.9 -1.6 2.0 1.0 -0.7 -1.3 1.1
Fed-up feelings 0.2 0.3 1.0 0.2 -1.0 -0.5 0.3 0.0 -0.0 0.0 -0.9 -0.6 1.0 -0.8 0.1 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.9 1.2 -0.3 0.2 1.0 0.4 0.1 0.7 0.6 1.0 1.4 1.3 0.5 -0.7
Relative age voice broke 0.9 1.4 3.8 -0.5 1.3 1.3 0.6 -2.0 1.4 1.0 1.5 0.5 -0.2 1.7 0.6 -1.3
Taking other prescription medications 0.9 1.4 4.1 -0.6 -0.9 -1.4 -2.0 0.4 -1.2 -1.5 -1.5 -0.8 -1.1 0.2 -1.1 1.1
Age when periods started (menarche) 0.3 0.6 3.2 0.7 -0.6 -0.6 0.7 0.2 -0.0 -0.2 0.1 1.2 -1.1 1.8 -0.3 0.3
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 3.9 -1.8 -2.0 -1.6 -1.6 -0.2 -1.2 -1.1 -1.1 -1.0 -0.6 -0.9 -1.2 1.9
Heel bone mineral density (BMD) T-score, automated (left) 2.6 5.9 12.1 2.4 2.3 2.6 3.4 1.0 2.6 2.5 0.8 2.4 3.5 1.7 2.6 -2.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.4 0.5 0.6 0.6 0.0 0.6 -0.1 -0.2 0.2 0.7 -0.3 0.0 0.1 0.4
Qualifications: CSEs or equivalent 1.2 1.6 3.9 0.3 0.6 1.7 1.6 2.0 0.9 0.7 0.7 1.7 1.5 1.8 0.7 -0.8
Serious illness, injury or assault to yourself 1.2 1.4 3.7 -1.4 -1.2 -0.9 -1.8 -0.6 -0.8 -1.3 0.5 -1.9 -1.0 -0.5 -1.2 1.3
High blood pressure 2.2 6.3 15.6 2.2 2.8 1.9 2.1 1.5 2.2 2.8 1.0 3.1 4.0 1.6 2.7 -3.1
Hayfever, allergic rhinitis or eczema 2.3 5.0 8.4 -2.9 -1.1 -2.1 -2.4 -0.5 -2.4 -2.9 -2.3 -2.2 -2.5 -1.6 -2.6 2.3
Multivitamins +/- minerals 2.0 2.6 6.7 -1.8 -0.4 -0.9 -1.5 -2.1 -1.4 -2.0 0.2 -2.6 -1.6 -0.0 -1.9 2.0
Stomach or abdominal pain in last month 1.2 1.5 3.4 -1.5 -1.4 -0.5 -1.4 -0.5 -1.2 -1.2 -0.1 -1.8 -0.7 -1.2 -1.5 1.5
Supplements: Glucosamine 0.7 0.9 1.9 -0.6 1.0 -0.0 0.4 -1.2 -0.7 -1.1 -1.1 -1.4 -1.3 0.8 -1.3 0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 4.6 -2.1 0.0 0.1 -0.8 -0.5 -0.8 -0.5 0.0 -0.8 -0.7 -0.9 -1.1 -0.3
Medication: Atenolol 0.9 1.1 2.2 1.5 0.2 0.5 0.7 0.9 1.1 1.1 1.1 0.9 1.0 1.5 1.5 -0.9
Medication: Levothyroxine sodium 0.3 0.5 3.2 0.7 0.6 0.2 -0.6 1.8 0.3 -0.0 -1.1 0.0 -0.8 0.2 -0.1 -0.6
Sitting height 1.3 9.1 35.0 -1.4 -2.3 -2.1 -1.8 -5.9 -2.6 -2.6 -3.0 -3.8 -4.2 -1.5 -2.0 2.6
Chronic bronchitis/emphysema (father) 0.6 0.7 1.5 -1.2 -0.8 -0.6 -0.2 -0.0 -1.2 -1.0 0.2 -0.8 -0.5 -0.9 -1.2 1.1
High blood pressure (mother) 0.3 0.4 2.5 -0.1 -0.1 0.5 0.6 0.8 0.1 0.0 -1.6 0.8 0.1 0.5 0.0 -0.5
Body mass index (BMI) 0.9 4.0 15.5 2.4 0.9 2.8 0.5 2.3 1.5 2.0 0.8 2.1 3.9 0.5 2.2 -0.3
Impedance of leg (left) 0.6 3.0 10.6 0.1 2.9 0.0 1.9 0.5 1.7 1.6 1.2 2.5 0.2 1.5 1.0 -3.3
Leg predicted mass (left) 0.4 2.2 6.0 0.4 -2.3 0.0 -1.6 -2.2 -1.5 -1.1 -1.3 -1.6 -0.2 -1.4 -0.5 2.4
Trunk fat mass 0.4 1.9 6.4 2.2 0.9 1.9 0.1 0.6 0.7 1.3 0.2 1.9 2.5 0.2 1.5 -0.1
Waist circumference 1.0 3.6 12.7 2.9 0.9 2.5 0.6 1.9 1.1 1.8 1.5 1.9 3.6 -0.0 2.1 -0.3
Number of incorrect matches in round 0.1 0.2 0.7 0.6 0.1 0.2 0.2 0.1 0.3 0.6 0.8 0.8 -0.1 0.7 0.3 -0.6
Past tobacco smoking 2.5 4.6 11.5 -2.5 -1.1 -1.7 -2.0 -2.8 -1.8 -1.6 -2.3 -2.6 -3.4 -2.0 -2.1 0.8
Alcohol usually taken with meals 0.1 0.1 0.5 0.0 0.1 0.3 0.4 0.4 0.1 -0.2 -0.5 0.5 0.0 0.7 -0.3 0.3
Nervous feelings 0.3 0.6 2.0 -0.7 0.1 -1.0 -0.4 -1.3 -0.0 -0.1 -0.6 -1.0 -1.4 -0.3 -0.7 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 0.7 -0.0 0.7 -0.1 -0.6 -0.4 0.1 -1.0 -0.0 -0.0 0.7 -0.3 -0.2
Hearing difficulty/problems with background noise 0.6 1.0 2.9 1.0 0.6 0.8 0.4 1.7 0.6 1.2 1.7 1.4 0.9 0.2 0.9 -0.5
Hair/balding pattern: Pattern 2 0.3 0.3 1.7 -0.9 -0.1 -0.5 0.2 -0.4 -0.4 -0.5 -1.3 -0.1 -0.1 -0.1 -1.0 0.1
Had menopause 1.3 1.6 3.5 -0.9 -0.9 -0.6 -1.9 0.9 -1.0 -1.3 -1.4 -1.2 -1.9 -1.0 -1.5 1.2
Had other major operations 0.5 0.6 2.3 1.0 -0.2 0.9 -1.0 0.4 0.3 0.0 0.2 -0.0 1.0 1.5 0.4 0.9
Forced vital capacity (FVC) 0.7 2.6 8.9 -0.7 -2.6 -1.2 -0.8 -3.0 -1.3 -1.2 -1.1 -1.6 -2.3 -0.9 -0.9 1.6
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.1 10.4 2.9 1.8 2.5 2.5 1.2 2.1 2.0 0.3 2.6 3.2 2.0 2.4 -2.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.3 -0.4 -1.5 -0.2 -0.9 -0.4 -0.6 -0.9 -1.5 -0.4 -0.6 -0.3 -0.7 1.4
Qualifications: None of the above 0.1 0.3 1.5 0.3 0.5 0.3 0.5 1.2 0.1 0.2 1.0 0.8 0.4 -0.1 0.1 -0.1
Financial difficulties in last 2 years 0.3 0.4 1.5 -0.1 -1.0 -0.6 -0.7 -0.2 -0.4 -0.3 1.2 -0.6 0.5 -0.3 -0.6 0.4
Mouth/teeth dental problems 0.4 0.6 3.2 0.4 0.3 -0.2 0.6 1.3 0.7 0.5 -0.5 1.8 0.0 0.8 0.4 -0.2
Heart attack 0.3 0.3 1.1 0.6 -0.1 -0.3 0.2 -1.0 -0.1 0.3 1.1 -0.5 0.5 0.9 0.2 -0.6
Allergy 2.7 6.2 10.2 2.0 2.0 2.6 2.8 0.5 2.9 3.2 2.4 2.8 2.5 1.8 2.8 -2.8
Pain all over the body in last month 0.3 0.3 0.8 -0.7 0.1 -0.3 0.3 -0.6 -0.4 -0.4 0.3 -0.9 0.0 -0.5 -0.7 0.7
Diabetes (self-reported) 1.3 2.0 6.1 2.1 0.5 1.4 1.1 2.1 0.7 0.7 -1.6 1.3 2.5 -1.0 1.2 -0.5
Hayfever/allergic rhinitis (self-reported) 9.1 12.0 18.9 -3.6 -2.0 -2.8 -4.3 -2.3 -3.6 -4.2 -2.9 -4.1 -3.6 -3.6 -3.5 3.8
Medication: Ramipril 0.2 0.3 1.1 0.5 -0.6 -0.7 0.0 0.1 -0.3 -0.0 1.1 -1.0 -0.1 -0.4 -0.5 -0.1
Medication: Simvastatin 2.5 3.6 9.6 3.1 2.1 2.1 0.2 1.3 1.6 1.9 0.8 2.0 2.8 0.8 2.2 -1.7
Fluid intelligence score 2.6 5.3 15.0 2.2 1.6 2.5 2.7 1.0 2.6 2.2 1.5 1.3 1.9 3.9 2.6 -2.6
Illnesses of siblings 4.0 5.6 10.3 -2.3 -2.6 -1.9 -2.8 -1.7 -2.2 -2.6 -0.2 -3.2 -2.8 -1.8 -2.7 2.6
Neuroticism score 0.1 0.1 1.1 0.0 0.1 -0.2 -0.1 -1.0 0.2 0.3 -0.2 -0.3 0.1 0.4 -0.3 -0.4
Weight 0.2 1.0 3.2 1.8 -0.0 1.6 -0.4 -0.4 0.1 0.6 -0.4 0.7 1.8 -0.3 1.1 0.8
Impedance of arm (right) 0.4 1.7 6.2 -0.2 2.5 0.6 0.3 -0.4 0.9 0.8 1.1 1.6 -0.9 1.6 0.2 -2.5
Arm fat percentage (right) 0.8 3.2 10.2 2.1 1.1 2.7 0.2 2.0 1.1 1.6 1.2 2.2 3.2 0.8 1.7 -0.5
Trunk fat-free mass 0.7 4.0 9.7 -0.2 -2.8 -1.0 -1.7 -2.5 -2.2 -2.0 -1.8 -2.4 -1.5 -1.6 -1.1 3.1
Hip circumference 0.2 0.9 3.3 1.6 0.1 1.7 -0.6 -0.2 0.2 0.7 -0.0 0.6 1.8 -0.4 0.9 0.5
Time employed in main current job 0.3 0.4 1.0 0.5 -0.2 0.2 0.6 0.8 0.4 0.4 -1.0 0.5 0.7 -0.4 0.6 -0.8
Alcohol intake versus 10 years previously 0.5 0.7 3.8 1.7 -0.1 0.1 -0.1 2.0 -0.3 0.1 0.1 1.0 0.9 0.7 -0.4 0.5
Father’s age at death 0.5 0.6 2.5 -1.6 0.3 -0.6 0.8 0.8 0.1 -0.1 1.2 -0.4 -1.4 -0.0 -0.4 -0.2
Worrier / anxious feelings 1.5 2.9 6.3 0.9 2.0 1.6 1.8 0.2 2.2 2.3 0.9 1.3 1.2 1.9 1.7 -2.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.4 0.3 0.3 0.6 -0.3 0.1 0.1 0.2 -0.3 -0.2 0.6 0.5 -0.2 -0.1
Falls in the last year 0.3 0.4 1.5 -0.7 -0.0 0.5 0.3 0.1 -0.1 -0.0 1.2 -0.8 -0.6 1.2 -0.4 0.3
Hair/balding pattern: Pattern 3 0.5 0.8 2.9 -0.2 -1.2 -0.1 -0.7 -0.1 -1.0 -0.8 -0.7 -1.2 -1.7 -0.1 -1.1 0.8
Number of live births 1.8 2.5 4.8 1.9 1.3 2.2 0.1 2.2 1.2 1.5 -0.5 1.5 1.7 2.1 1.5 -1.4
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 3.8 0.2 -1.6 0.3 -0.1 -1.9 0.1 -0.0 -1.6 -0.9 -1.4 0.2 0.2 0.8
Pulse rate 2.1 3.6 7.0 0.8 2.1 1.6 0.4 1.5 2.0 2.5 2.5 2.6 2.5 0.6 2.0 -1.7
Happiness 0.7 0.8 3.1 -0.7 -1.2 0.5 -0.4 0.6 -1.2 -1.2 -0.3 -0.8 -0.4 0.1 -0.9 1.8
Noisy workplace 1.0 1.3 3.8 0.7 -0.1 1.2 1.9 1.3 1.1 0.7 1.4 1.0 0.9 1.8 0.9 -0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.0 0.7 1.0 0.6 0.1 -0.5 -0.0 0.0 0.3 -0.8 -0.2 -0.6 0.4 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.3 3.2 -0.5 -1.7 0.5 -1.4 -0.6 -1.0 -1.8 -0.9 -1.6 -1.3 0.1 -1.1 1.1
Mouth/teeth dental problems: Dentures 0.6 1.0 3.8 -1.1 -0.2 -0.6 -1.6 -0.7 -1.0 -0.5 -0.0 -1.6 -0.1 -2.0 -0.9 0.5
Asthma 0.3 0.6 2.0 -0.2 -1.4 -1.1 -0.6 0.4 -0.9 -0.9 -0.9 -0.6 0.0 1.0 -0.6 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.9 0.8 -0.7 0.3 0.4 0.3 -0.1 -0.2 0.3 -0.2 0.9 0.2 0.2 0.1
Medication: Cholesterol lowering 1.7 2.7 7.9 2.1 1.5 0.6 0.9 1.1 1.4 1.7 0.4 2.8 2.6 0.8 1.3 -1.8
Depression (self-reported) 1.8 2.2 4.7 -1.3 -0.6 -0.4 -1.6 -0.9 -1.6 -2.2 -2.0 -1.1 -1.4 -1.1 -1.8 1.9
Medication: Lansoprazole 1.3 1.5 5.8 0.3 -1.3 -0.8 -1.5 -0.5 -0.8 -1.2 -1.6 -1.2 -0.8 2.4 -1.0 1.2
Prospective memory result 0.5 0.6 4.2 -0.4 2.0 0.9 -1.1 0.4 -0.1 -0.2 0.4 -0.0 -0.0 0.6 -0.3 0.5
Lung cancer (father) 0.3 0.3 0.7 -0.8 -0.1 -0.1 -0.1 0.4 -0.7 -0.7 -0.1 -0.8 -0.3 -0.6 -0.7 0.8
Illnesses of mother 1.6 1.9 5.6 -1.4 -1.1 -1.0 -1.4 -2.4 -1.3 -1.1 0.8 -1.6 -1.4 -1.5 -0.8 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.1 10.0 -0.5 -1.7 -0.5 -0.2 -3.2 -0.7 -0.7 -2.0 -1.9 -1.7 -0.5 -0.4 1.1
Pulse wave Arterial Stiffness index 2.0 2.4 3.9 0.6 1.6 1.2 1.2 1.1 1.7 1.9 2.0 1.6 2.0 1.7 1.3 -1.6
Impedance of arm (left) 0.3 1.2 5.6 -0.5 2.2 0.4 0.3 -1.1 0.4 0.4 0.6 1.1 -1.1 0.9 -0.1 -2.4
Arm fat mass (right) 0.5 2.2 8.7 2.1 0.4 2.4 0.1 1.2 0.7 1.2 0.4 1.6 3.0 0.3 1.6 0.3
Trunk predicted mass 0.7 3.9 9.5 -0.1 -2.8 -0.9 -1.7 -2.4 -2.2 -2.0 -1.8 -2.3 -1.5 -1.6 -1.1 3.1
Standing height 0.8 7.5 30.1 -0.9 -1.8 -2.1 -1.8 -5.5 -2.7 -2.5 -2.5 -2.6 -4.1 -1.7 -2.1 2.3
Length of working week for main job 0.9 1.0 6.3 -0.4 -1.6 -0.0 -0.4 -1.0 -0.7 -0.2 -0.4 -0.9 -0.7 -2.5 -0.3 0.5
Exposure to tobacco smoke at home 2.6 3.0 7.0 -1.4 -2.6 -1.2 -1.3 -0.7 -1.8 -2.1 -1.1 -1.2 -1.5 -1.9 -1.7 2.6
Breastfed as a baby 1.6 2.0 7.6 2.8 0.5 0.9 0.0 1.1 1.4 1.3 0.4 1.6 1.3 2.2 1.6 -1.2
Tense / ‘highly strung’ 0.2 0.4 0.9 0.7 0.9 0.6 0.9 -0.9 0.5 0.6 -0.5 0.4 0.6 0.1 0.2 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 1.1 -0.5 0.1 0.5 1.1 -0.2 0.1 -0.1 -0.4 0.5 0.6 0.2 -0.0 0.1
Hair/balding pattern: Pattern 4 2.1 5.2 10.3 2.2 2.0 2.3 2.0 0.8 2.8 2.8 0.9 2.6 2.0 1.6 3.2 -2.9
Birth weight of first child 2.4 4.4 9.5 2.7 1.7 2.1 2.0 1.3 2.7 2.6 0.5 1.2 0.5 3.1 2.5 -2.0
Peak expiratory flow (PEF) 0.9 2.2 4.5 -0.7 -1.9 -1.0 -1.3 -0.9 -0.9 -1.3 -2.0 -1.6 -2.1 1.3 -1.4 1.9
Pulse wave reflection index 1.7 2.1 5.2 0.5 1.3 1.1 1.6 0.3 1.4 1.4 2.3 1.2 1.1 2.1 1.4 -1.8
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.9 0.8 0.8 1.4 0.8 0.1 1.0 1.1 1.7 0.9 0.9 0.6 1.1 -0.8
Loud music exposure frequency 0.8 0.8 2.5 0.3 0.4 1.2 0.3 1.5 1.0 0.7 1.0 0.3 1.6 0.1 1.2 -0.5
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.4 0.5 -0.2 -0.3 -0.2 0.6 0.4 0.3 0.2 0.5 0.6 0.4 -0.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.3 1.0 0.4 1.1 1.1 -0.0 0.4 0.4 0.6 -0.7 -0.1 0.5 0.4 -0.4
Blood clot in the leg (DVT) 2.4 3.2 7.7 -0.5 -2.1 -1.3 -2.3 -0.9 -1.9 -2.1 0.0 -2.0 -1.9 -0.9 -2.0 2.8
Medication: Paracetamol 0.5 0.8 3.1 -0.3 0.9 0.8 0.4 0.5 0.8 0.9 1.6 0.5 1.8 0.3 0.9 -0.9
Headache pain in last month 0.1 0.2 1.2 -0.5 0.3 -0.3 -0.5 -0.4 -0.7 -0.4 0.6 -0.2 0.2 1.1 -0.4 0.2
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 7.8 -1.6 -1.4 -0.5 -1.1 -1.4 -1.5 -1.7 -0.3 -2.5 -2.8 -0.9 -1.2 1.8
Glaucoma (self-reported) 3.1 3.6 6.8 1.4 2.0 1.5 2.0 2.0 2.6 2.2 0.0 1.6 1.8 1.3 2.6 -2.2
Gout (self-reported) 0.5 0.7 2.1 1.3 -0.5 0.1 -0.0 0.9 0.2 0.3 -0.7 1.5 1.3 0.9 0.7 -0.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.8 0.2 -0.5 -0.5 -1.6 1.7 -0.8 -1.1 -2.0 -0.4 -1.9 -0.3 -1.1 0.3
Medication: Amlodipine 2.1 3.0 5.8 1.3 1.5 2.4 0.9 2.1 1.7 1.7 2.0 2.0 2.2 1.0 1.8 -1.2
Medication: Ventolin 100micrograms inhaler 0.2 0.2 1.0 -0.0 -0.7 0.0 0.4 1.0 -0.2 -0.2 -0.1 0.2 0.7 0.6 0.1 0.1
Birth weight 0.3 0.7 5.6 0.0 0.1 -0.7 0.0 -2.4 -0.7 -0.3 -0.9 -0.7 -0.7 0.6 -0.3 0.3
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.4 -1.2 -0.5 -1.3 -1.4 -0.2 -1.2 -1.6 -0.3 0.0 -0.6 -0.3 -1.5 1.8
High blood pressure (siblings) 1.4 2.0 3.8 0.7 1.8 1.4 2.0 0.2 1.5 1.4 -0.5 1.8 1.7 1.1 1.5 -1.6
Forced vital capacity (FVC), Best measure 1.5 5.3 19.8 -1.4 -2.8 -2.0 -1.1 -4.4 -2.0 -1.9 -1.8 -2.7 -2.8 -1.3 -1.6 2.0
Body fat percentage 0.9 3.7 11.4 2.4 1.7 2.4 0.4 1.7 1.4 1.9 0.8 2.8 3.4 0.6 2.0 -0.9
Leg fat percentage (right) 1.7 6.3 16.6 2.6 1.7 2.8 1.0 2.9 2.1 2.6 0.9 3.7 4.1 1.6 2.6 -1.6
Arm fat-free mass (right) 0.4 2.2 6.2 0.5 -2.3 -0.5 -1.2 -2.0 -1.4 -1.1 -1.6 -1.5 -0.3 -1.6 -0.4 2.5
Exposure to tobacco smoke outside home 0.8 1.1 5.2 -0.6 -2.3 -1.0 -0.8 -1.3 -1.2 -0.9 -0.6 -0.6 -0.1 -0.6 -0.7 1.3
Comparative body size at age 10 0.3 0.9 2.2 -0.6 -0.2 -0.5 0.4 -0.4 -1.5 -1.3 1.3 -1.5 -0.8 -0.7 -1.1 0.8
Number of full brothers 1.0 1.2 3.5 0.1 1.7 1.3 0.8 0.3 0.9 0.9 -0.1 1.7 1.9 0.1 1.2 -1.1
Worry too long after embarrassment 0.9 1.5 5.0 1.1 0.7 0.8 1.1 -0.2 1.4 1.3 0.1 1.3 1.0 2.2 1.0 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.8 -0.7 0.0 0.1 0.2 -0.8 -0.6 -0.6 -1.2 0.1 1.4 -0.2 -0.6 0.9
Wheeze or whistling in the chest in last year 0.4 0.7 1.8 0.6 -1.3 -0.6 -0.4 1.1 -0.4 0.0 -1.3 0.7 1.4 0.7 -0.1 0.5
Number of children fathered 0.4 0.4 1.5 0.1 -0.7 -0.6 0.8 0.3 -0.2 -0.9 -0.1 -0.4 0.4 1.2 -0.5 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 3.7 1.3 1.7 1.0 1.6 1.0 1.3 1.0 0.5 1.6 1.9 0.6 1.3 -1.1
Age at first live birth 0.3 0.5 2.6 0.4 -1.1 -0.7 0.1 -0.8 0.1 -0.3 -0.4 -1.1 -1.6 0.6 0.0 0.1
Pulse wave peak to peak time 2.5 3.0 5.3 -0.8 -1.8 -1.4 -1.2 -1.4 -1.9 -2.1 -2.1 -1.7 -2.3 -1.8 -1.5 1.8
Health satisfaction 0.4 0.6 3.8 0.6 -0.7 -0.0 -1.2 0.3 -0.4 -0.4 -2.0 0.3 0.0 -0.4 -0.3 0.6
Shortness of breath walking on level ground 0.5 0.6 4.8 1.0 0.3 0.1 0.1 -0.5 -0.4 -0.5 -2.2 0.5 0.4 -0.4 -0.3 1.0
Qualifications: College or University degree 0.4 1.1 2.5 0.1 -0.8 -0.9 -0.8 -1.6 -1.0 -1.5 -1.6 -1.3 -1.1 0.3 -0.9 0.7
Eye problems/disorders: None of the above 0.4 0.4 1.4 -0.1 0.9 0.8 -0.1 0.1 0.7 0.5 1.2 0.2 0.2 1.2 0.4 -0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.7 0.3 -1.1 -0.7 -1.0 1.6 -0.6 -0.5 1.3 0.4 -0.1 0.0 -0.6 0.7
Emphysema/chronic bronchitis 0.4 0.4 2.4 0.7 0.4 0.6 0.3 -0.4 0.3 0.2 1.6 0.5 1.1 0.2 0.5 0.0
Medication for pain relief, constipation, heartburn 1.0 1.8 5.1 -1.4 -0.6 -1.3 -0.9 -1.9 -1.1 -1.4 -0.7 -0.9 -2.3 -1.3 -1.4 1.3
Neck or shoulder pain in last month 0.6 0.9 2.0 -0.6 -0.3 0.7 -1.4 -1.3 -0.8 -1.1 -0.2 -1.3 -0.7 0.3 -1.3 1.0
Medication: Blood pressure 1.0 1.8 5.9 1.5 0.9 0.6 1.0 1.0 0.9 1.4 1.0 1.9 2.4 1.3 1.1 -1.3
Angina (self-reported) 1.1 1.4 3.5 0.8 1.6 0.8 1.4 -0.0 1.0 1.2 1.9 0.5 1.8 0.8 1.0 -1.3
Migraine (self-reported) 0.2 0.3 1.5 -0.3 -0.4 -0.4 -1.2 0.3 -0.1 -0.3 -0.1 -0.5 -0.8 -0.3 0.1 0.5
Medication: Ibuprofen 0.1 0.2 0.6 0.4 -0.8 0.0 -0.2 0.2 -0.4 -0.6 0.5 -0.4 0.5 -0.3 -0.2 0.2
Medication: Allopurinol 0.2 0.3 1.4 -0.2 -1.0 -0.7 -1.2 0.2 -0.7 -0.5 0.1 -0.2 0.3 -0.0 -0.2 0.5
Medication: Omeprazole 0.4 0.4 1.7 0.5 0.4 0.6 -0.2 1.3 0.5 0.4 1.0 0.6 0.6 0.9 0.1 -0.2
Medication: Seretide 50 evohaler 4.2 4.9 9.3 -3.0 -2.2 -2.7 -0.5 -1.4 -2.5 -2.4 0.4 -2.4 -1.3 -2.8 -2.5 2.3
Mean time to correctly identify matches 1.2 2.3 5.7 1.9 -0.3 0.7 1.4 2.4 1.4 1.3 -1.2 1.8 2.2 -1.3 1.5 -1.2
Heart disease (mother) 3.8 4.7 11.4 2.1 2.2 1.6 3.4 1.3 2.1 2.0 1.3 1.8 2.9 2.3 1.6 -2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 4.7 -1.0 -0.1 0.1 1.3 2.2 0.9 0.6 1.6 0.6 0.5 1.8 0.5 -0.1
Whole body fat mass 0.6 2.4 9.7 2.1 0.9 2.1 0.3 1.2 0.9 1.5 0.5 2.0 3.1 0.1 1.7 -0.2
Leg fat mass (right) 0.7 2.9 11.5 2.2 0.8 2.3 0.5 1.4 1.0 1.6 0.5 2.3 3.4 0.6 1.9 -0.3
Arm predicted mass (right) 0.4 2.1 6.5 0.5 -2.2 -0.5 -1.2 -1.9 -1.4 -1.2 -1.6 -1.6 -0.3 -1.5 -0.3 2.5
Pulse rate, automated reading 3.4 11.1 22.2 2.2 2.6 3.2 3.0 3.4 3.8 4.2 2.9 3.9 4.7 0.7 3.8 -3.2
Alcohol intake frequency. 0.6 1.4 3.7 -0.6 -0.8 -1.3 -1.9 0.3 -1.2 -1.1 -1.3 -1.3 -1.7 -0.2 -1.1 1.4
Comparative height size at age 10 0.4 2.1 4.1 0.4 -1.0 -1.3 -0.3 -1.7 -2.0 -1.9 -2.0 -1.2 -1.4 -1.3 -1.4 1.9
Number of full sisters 0.9 1.1 3.2 1.8 0.0 0.9 -0.2 0.8 1.0 1.0 -0.6 1.7 1.4 0.7 1.1 -0.7
Suffer from ‘nerves’ 0.5 0.8 3.3 -0.1 -1.1 -0.5 -0.4 -0.9 -0.5 -0.5 -1.8 -0.5 -1.8 -0.7 -0.5 0.4
Overall health rating 0.3 0.6 2.6 0.7 -0.3 1.1 0.5 1.3 0.5 0.6 -0.2 0.3 1.6 0.7 0.4 0.1
Chest pain or discomfort 1.9 2.7 6.8 2.3 0.9 0.8 2.0 0.5 1.2 1.8 0.8 1.6 2.6 1.9 1.4 -1.8
Had major operations 0.1 0.2 0.4 -0.5 0.2 -0.3 0.5 0.6 -0.5 -0.4 0.2 -0.3 -0.5 -0.0 -0.6 0.1
Age at last live birth 0.4 0.6 4.0 0.7 -0.7 -1.1 -0.0 0.2 0.1 -0.0 -0.3 -0.1 -0.8 2.0 0.2 -0.1
Family relationship satisfaction 0.3 0.3 1.7 -0.1 -0.6 0.0 0.2 0.4 -0.3 -0.5 1.3 -0.6 0.4 0.5 -0.2 0.8
Leg pain on walking 0.4 0.5 2.1 0.8 -0.4 0.6 0.4 1.4 0.3 0.4 -1.0 0.4 1.2 -0.5 0.5 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.7 0.1 -0.8 0.3 0.0 0.4 -0.2 -0.1 -0.8 -0.1 0.1 0.6 -0.4 0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.8 0.9 0.1 0.4 0.8 0.3 -0.2 -0.5 -0.5 0.1 -0.1 0.0 -0.7 0.5
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.8 0.7 1.7 -0.2 1.3 -0.3 0.3 0.8 -0.9 1.2 0.1 0.2 1.0 -1.0
Medication: Aspirin 2.2 2.9 8.0 2.8 0.6 1.1 1.2 1.8 1.4 1.8 0.4 1.3 2.1 2.8 1.5 -1.2
Supplements: Vitamin C 0.1 0.1 0.6 0.2 0.8 0.5 -0.0 0.0 0.2 -0.0 -0.1 0.2 -0.2 -0.1 0.5 -0.2
Knee pain experienced in last month 0.2 0.4 1.6 -0.3 -0.3 -1.0 -0.8 -0.6 -0.1 0.0 -1.2 -0.7 0.4 -0.4 -0.4 0.3
Hypertension (Self-reported) 2.1 5.8 14.6 2.3 2.6 1.9 1.9 1.7 2.1 2.7 0.7 2.9 3.8 1.3 2.6 -3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 3.8 0.3 -1.0 0.1 -1.3 -0.2 -1.1 -1.2 -0.5 -0.7 -1.3 2.0 -1.2 1.3
Illnesses of father: Heart disease 0.5 0.8 2.7 0.7 1.6 1.1 -0.0 -0.1 0.5 0.5 -0.2 1.2 0.7 1.3 0.8 -0.6
Illnesses of siblings: Diabetes 0.2 0.2 1.1 -1.0 0.5 0.2 -0.1 0.4 -0.1 -0.2 -0.7 -0.3 -0.0 -0.4 0.5 0.3
Smoking status: Previous 1.2 1.8 5.5 1.8 0.9 0.8 1.3 1.0 1.1 1.0 1.2 1.7 2.4 1.6 1.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 2.3 0.9 0.1 0.4 1.2 -1.1 0.2 0.1 0.7 -0.2 0.2 1.5 0.3 -0.6
Whole body fat-free mass 0.6 3.1 8.3 0.2 -2.6 -0.6 -1.6 -2.4 -1.9 -1.6 -1.7 -2.0 -0.9 -1.6 -0.8 2.9
Leg fat-free mass (right) 0.4 2.3 6.1 0.5 -2.2 0.0 -1.4 -2.5 -1.4 -1.1 -1.3 -1.8 -0.2 -1.8 -0.5 2.3
Arm fat percentage (left) 0.8 3.3 11.1 2.2 1.1 2.8 0.2 1.8 1.2 1.7 1.1 2.2 3.3 0.6 1.8 -0.6
Average weekly red wine intake 0.9 1.3 3.8 1.5 0.6 1.5 1.0 1.0 0.7 0.5 -0.5 2.0 1.2 1.8 1.0 0.2
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.5 1.2 1.1 2.0 1.0 1.3 1.0 1.3 1.6 1.1 2.1 0.4 1.2 -0.9
Mood swings 0.1 0.2 1.1 -0.7 -0.2 0.1 0.7 -0.6 0.1 -0.3 -0.6 -0.2 1.0 -0.0 -0.0 0.5
Loneliness, isolation 0.3 0.4 1.9 0.1 -0.0 0.5 0.3 -0.3 0.3 0.4 1.1 0.4 0.9 1.4 0.2 -0.4
Long-standing illness, disability or infirmity 0.7 1.0 3.0 -0.6 -1.6 -1.5 -1.0 -0.4 -0.9 -0.9 -1.7 -0.4 -0.5 0.8 -0.9 0.4
Ever had bowel cancer screening 0.4 0.4 1.2 -0.7 -0.9 -0.0 -0.4 -0.6 -0.6 -0.3 0.2 -0.8 -1.1 1.0 -0.7 -0.2
Diabetes diagnosed by doctor 2.0 3.3 7.6 2.7 1.1 2.1 1.4 2.3 1.5 1.4 -1.2 1.9 2.7 -0.1 1.9 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.3 -0.5 1.1 -0.4 0.2 -0.4 0.1 0.1 0.8 0.7 0.9 0.3 0.6 -0.7
Friendships satisfaction 0.3 0.4 1.8 0.5 -0.3 0.7 1.0 0.6 0.1 0.1 0.9 -0.7 -0.1 1.3 0.2 -0.0
Qualifications: nursing, teaching 1.5 2.3 4.3 -1.1 -2.1 -1.1 -1.1 -1.0 -2.0 -1.8 -1.4 -1.6 -1.7 -0.8 -1.8 1.7
Commuting to job workplace: Walk 0.5 0.5 3.8 -1.0 1.0 -0.5 0.2 -0.3 0.4 -0.0 1.9 -0.1 -0.2 -0.2 0.6 -0.3
Eye problems/disorders: Cataract 0.6 0.7 1.9 1.4 -0.0 -0.6 0.9 1.1 0.4 0.7 -1.2 1.1 0.3 -0.4 0.3 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 3.2 0.9 0.7 0.7 1.1 -0.5 0.3 0.5 -0.3 0.5 0.4 1.8 0.5 -1.1
Medication for cholesterol 2.3 3.5 6.2 -1.4 -1.4 -1.8 -1.9 -2.4 -2.3 -2.5 -0.2 -1.4 -2.4 -0.9 -2.1 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.5 -0.8 -1.2 0.4 -0.8 -1.0 -0.8 -0.5 -0.2 -1.4 -1.6 -1.4 -0.7 0.6
Back pain experienced in last month 0.6 0.9 6.3 1.3 -1.6 0.4 -0.2 0.6 -0.3 -0.1 -2.5 -0.7 -0.1 0.8 -0.0 0.0
Mineral and other dietary supplements 3.5 4.6 9.3 2.3 1.0 2.0 1.1 1.9 2.2 2.8 2.1 2.3 3.0 0.2 3.0 -2.2
Breast cancer (self-reported) 1.4 1.6 4.9 -0.4 -1.4 -0.6 -1.7 -0.4 -1.2 -1.2 -1.1 -2.2 -1.4 -0.4 -1.1 1.8
Asthma (self-reported) 0.6 1.2 3.5 -0.7 -1.9 -1.4 -1.1 0.2 -1.2 -1.2 -1.1 -0.8 -0.4 0.7 -1.0 1.1
Osteoporosis (self-reported) 0.4 0.5 2.3 -0.6 -0.3 -1.5 -1.2 -0.2 -0.3 0.2 0.6 -0.1 -1.1 0.1 -0.7 -0.2
Osteoarthritis (self-reported) 0.3 0.4 2.6 1.0 -1.0 -0.5 -0.7 0.7 0.2 -0.0 -1.6 0.0 0.2 0.2 -0.1 0.1
Medication: Aspirin 1.8 2.3 5.9 2.4 0.4 1.2 0.8 2.0 1.2 1.6 0.6 0.9 2.0 2.3 1.4 -1.0
Medication: Gliclazide 0.3 0.3 0.7 0.8 0.3 0.5 0.4 0.8 0.6 0.7 -0.6 0.1 0.8 -0.0 0.5 -0.7
Illnesses of father: None of the above (group 1) 0.4 0.6 1.5 -1.1 -1.2 -0.6 -0.2 0.9 -0.5 -0.8 -0.2 -0.8 -0.2 -0.8 -0.7 0.8
Smoking status: Current 0.8 1.3 6.5 0.2 -0.3 0.6 0.3 2.6 0.7 0.7 2.1 1.1 1.2 1.2 0.6 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.9 0.6 -0.9 0.1 -0.2 -0.7 0.7 0.8 -0.8 -0.8 -0.7 0.1 0.8 -0.9
Whole body water mass 0.6 3.2 8.8 0.2 -2.7 -0.5 -1.6 -2.4 -1.8 -1.6 -1.8 -2.0 -0.9 -1.6 -0.8 3.0
Leg predicted mass (right) 0.4 2.2 5.8 0.6 -2.2 0.1 -1.3 -2.4 -1.4 -1.1 -1.3 -1.7 -0.2 -1.7 -0.4 2.3
Arm fat mass (left) 0.6 2.4 9.2 2.2 0.5 2.5 0.0 1.2 0.9 1.5 0.6 1.8 3.0 0.3 1.8 0.0
Number of self-reported non-cancer illnesses 0.4 0.8 3.0 -0.1 0.5 -0.5 -1.7 1.3 -0.6 -1.0 -1.5 0.7 0.4 0.2 -0.3 0.7
Average weekly champagne plus white wine intake 0.2 0.2 1.3 0.3 0.0 -0.3 1.1 -0.5 0.2 0.2 0.7 -0.4 0.4 -0.1 -0.0 -0.3
Miserableness 0.4 0.6 1.4 0.5 0.6 0.5 0.3 0.5 0.9 0.8 -0.1 0.9 1.2 1.0 0.7 -1.1
Guilty feelings 0.6 0.9 2.7 0.2 1.1 0.5 0.2 -0.5 1.1 1.3 0.6 1.0 1.4 0.2 1.1 -1.6
Wears glasses or contact lenses 0.6 0.7 3.4 0.8 0.9 0.9 -0.5 0.5 0.4 0.5 0.3 0.9 -0.1 1.8 0.3 -1.3
Ever taken oral contraceptive pill 0.5 0.6 2.4 -0.4 -1.2 -1.2 -0.1 0.4 -0.6 -0.7 -0.6 -0.0 -0.3 -1.6 -0.4 0.6
Hearing aid user 0.9 1.0 3.3 -0.9 -0.1 -1.4 -1.5 0.3 -0.6 -0.3 -1.8 -0.2 -1.3 -0.8 -1.2 0.3
Mother’s age at death 2.6 3.3 7.4 -1.8 -1.0 -1.7 -0.7 -1.7 -1.8 -2.3 -1.0 -2.7 -2.5 -1.4 -1.8 2.0
Financial situation satisfaction 2.1 2.6 5.8 -0.9 -2.4 -1.5 -1.1 -0.7 -1.8 -1.8 -0.7 -1.7 -1.0 -2.4 -1.4 2.3
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.6 1.3 0.3 0.5 0.8 0.6 0.4 0.1 -0.9 0.3 -0.0 1.2 0.0 0.3
Commuting to job workplace: Public transport 0.9 1.1 2.5 -1.0 0.1 -0.6 -1.1 -1.6 -1.3 -0.9 1.2 -1.4 -0.3 -1.0 -0.6 1.2
Eye problems/disorders: Glaucoma 3.0 3.5 7.0 1.6 1.4 1.4 2.2 2.6 2.4 2.0 0.6 1.6 1.9 1.1 2.4 -2.0
Medication: Blood pressure 2.4 4.5 8.4 1.8 2.2 2.6 1.8 1.6 2.0 2.5 1.5 1.9 2.9 1.1 2.5 -2.5
Pain type(s) experienced in last month: Hip pain 2.0 2.5 8.1 1.6 0.1 0.5 -0.3 2.1 1.9 1.6 -0.1 1.3 1.9 2.8 1.6 -1.7
Supplements: Fish oil (including cod liver oil) 3.9 5.2 10.6 -2.5 -1.3 -1.6 -1.4 -1.6 -2.3 -3.1 -2.4 -2.2 -3.3 -0.7 -2.9 2.7
High cholesterol (Self-reported) 0.9 1.7 4.8 0.8 2.2 1.1 0.1 1.6 0.8 1.3 0.1 1.8 1.1 1.8 0.6 -1.6
Medication: Bendroflumethiazide 1.7 2.6 5.5 1.6 0.8 1.3 1.7 2.0 1.8 1.8 -0.3 2.3 2.0 -0.0 2.0 -1.6
Medication: Paracetamol 0.6 0.9 3.6 -0.2 0.7 0.6 0.2 0.9 1.1 0.9 1.3 0.7 1.9 -0.3 1.0 -0.9
Medication: Lisinopril 1.0 1.2 4.0 0.3 1.5 1.3 0.5 0.5 1.0 1.4 0.6 1.1 2.0 -0.0 1.2 -1.3
Medication: Atorvastatin 0.9 1.1 2.8 -1.6 -0.2 -0.9 -1.2 -0.3 -1.4 -1.1 -0.2 -0.7 -1.0 -0.7 -1.7 0.9
Illnesses of father: High blood pressure 0.6 0.8 2.8 0.1 1.5 0.7 0.7 -0.6 1.0 0.9 0.6 0.6 0.7 0.5 0.6 -1.7
Alcohol drinker status: Never 1.5 1.9 5.4 -2.0 -0.2 -1.2 -0.2 -1.8 -1.4 -1.4 -0.8 -2.3 -1.5 -0.9 -1.0 0.8
Ever smoked 2.2 3.8 11.7 2.3 0.6 1.6 1.9 2.8 1.5 1.3 2.1 2.0 3.4 1.6 1.9 -0.4
Basal metabolic rate 0.3 1.9 5.8 0.6 -2.0 -0.0 -1.3 -2.0 -1.4 -1.1 -1.3 -1.3 -0.2 -1.3 -0.3 2.4
Leg fat percentage (left) 1.7 6.3 18.2 2.9 1.7 2.8 1.1 2.8 2.1 2.6 0.7 3.6 4.3 1.3 2.6 -1.5
Arm fat-free mass (left) 0.3 1.8 6.2 0.7 -2.1 -0.3 -1.2 -1.6 -1.3 -1.0 -1.6 -1.1 -0.2 -1.0 -0.3 2.5
Number of operations (self-reported) 0.6 0.9 2.8 -1.0 -1.0 -0.7 -1.7 0.1 -0.9 -1.0 -0.4 -0.7 -0.8 0.5 -1.1 1.4
Average weekly beer plus cider intake 1.8 2.6 6.5 1.9 1.1 1.4 0.8 2.1 1.3 1.5 0.0 2.4 2.6 1.2 1.7 -1.1
Irritability 0.5 0.8 2.8 0.3 0.0 -1.6 -1.4 -1.7 -0.6 -0.6 -0.2 -0.8 -0.1 -0.8 -0.7 0.9
Risk taking 1.0 1.4 3.9 -1.2 -1.9 -1.3 0.0 -1.2 -1.3 -1.1 0.9 -2.0 0.1 -0.7 -0.8 1.1
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.6 -1.3 -0.1 -1.3 -1.4 -1.2 -1.0 -1.3 -0.3 -0.9 -1.6 0.2 -0.9 0.8
Fractured/broken bones in last 5 years 3.7 4.8 8.2 -2.7 -2.8 -2.0 -1.7 -1.7 -2.0 -2.2 -1.1 -2.9 -2.7 -1.5 -2.0 2.5
Age started oral contraceptive pill 0.5 0.6 3.1 0.8 0.9 0.6 0.1 -0.1 0.6 0.7 -1.8 0.4 -0.0 -0.6 0.7 -1.2
Diastolic blood pressure, automated reading 2.2 6.8 15.3 1.8 2.4 2.7 1.2 2.0 3.1 3.1 0.7 3.9 3.2 2.5 2.7 -2.8
Ever depressed for a whole week 0.3 0.4 0.9 -0.4 -0.1 0.5 -0.3 -0.6 -0.7 -0.6 -0.9 -0.1 -0.6 -0.6 -0.7 0.9
Unable to work because of sickness or disability 0.2 0.3 2.3 -0.2 -0.1 -0.4 0.0 1.5 -0.5 -0.5 -0.3 -0.6 -0.2 0.6 -0.5 0.3
Commuting to job workplace: Cycle 0.4 0.5 3.3 0.3 0.1 0.1 1.8 -0.9 0.6 0.6 0.3 0.1 0.7 0.0 0.5 -0.7
Myopia 0.9 1.2 4.9 -1.5 0.2 -0.5 -1.6 -2.2 -0.6 -1.0 -0.6 -0.8 -1.6 -0.6 -0.8 0.6
Vascular/heart problems diagnosed by doctor 2.3 6.4 17.6 -2.3 -2.7 -2.1 -1.9 -1.1 -2.3 -3.0 -1.1 -2.8 -4.2 -1.5 -2.8 3.1
Cholesterol lowering medication 0.6 0.8 3.0 0.9 1.0 1.7 0.1 1.1 0.6 1.0 -0.7 0.5 0.9 0.6 0.9 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 0.1 -0.5 0.0 -0.6 0.6 0.0 -0.0 0.2 0.1 -0.1 0.4 -0.1 0.1
Pain experienced in last month 0.2 0.3 1.4 0.0 -0.7 -0.9 0.5 0.7 0.0 -0.3 -0.3 0.3 -0.6 -1.2 -0.1 0.3
Supplements: Calcium 2.4 2.7 8.2 -2.6 -0.9 -1.1 -0.9 -0.1 -1.4 -1.9 -0.1 -2.0 -2.9 -0.8 -2.1 1.5
Basal cell carcinoma (self-reported) 0.2 0.2 1.8 0.4 0.0 -0.0 0.2 -0.3 0.3 0.5 -0.1 0.5 0.0 1.4 -0.0 -0.6
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.0 0.7 -0.3 -0.2 0.1 -1.0 -0.0 0.3 0.8 -0.5 0.3 1.0 0.2 -0.6
Deep venous thrombosis (DVT) (self-reported) 3.3 4.2 9.9 -0.8 -2.3 -1.4 -2.6 -1.0 -2.3 -2.5 0.0 -2.4 -2.4 -1.1 -2.3 3.1
Heart disease (siblings) 6.3 7.8 14.2 2.1 3.8 2.4 1.9 1.4 2.7 3.2 2.7 3.8 3.2 1.4 2.8 -3.4
Alcohol drinker status: Previous 0.9 1.0 2.7 0.7 0.4 0.4 -0.0 1.6 1.3 1.1 -0.5 1.5 1.2 1.0 1.1 -0.5
Pack years of smoking 0.7 1.1 4.3 1.5 0.1 0.1 0.5 1.1 0.6 0.9 -0.5 2.1 2.0 -0.4 0.7 -0.5
Impedance of whole body 0.4 2.0 8.2 -0.3 2.7 -0.0 0.9 -0.5 1.0 1.0 0.9 1.9 -0.7 1.5 0.3 -2.9
Leg fat mass (left) 0.7 2.8 12.0 2.3 0.7 2.2 0.6 1.3 1.0 1.6 0.3 2.1 3.5 0.4 1.8 -0.2
Arm predicted mass (left) 0.3 1.6 6.1 0.7 -2.0 -0.2 -1.0 -1.5 -1.2 -0.9 -1.4 -1.0 0.0 -1.0 -0.2 2.5