Best TWAS P=4.66e-15 · Best GWAS P=1.29e-17 conditioned to 9.43e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | LOXL2 | 0.48 | 0.01 | enet | 8 | 0.00 | 3.8e-01 | 3.3 | 5.6 | 2.1e-08 | -0.06 | 0.05 | 0.39 | TRUE |
| 2 | GTEx | Esophagus Muscularis | LOXL2 | 0.19 | 0.06 | lasso | 6 | 0.07 | 6.0e-05 | 6.6 | 5.8 | 8.1e-09 | 0.05 | 0.01 | 0.98 | TRUE |
| 3 | NTR | Blood | R3HCC1 | 0.02 | 0.01 | enet | 13 | 0.02 | 6.7e-06 | -5.3 | 5.5 | 4.7e-08 | 0.04 | 0.89 | 0.07 | TRUE |
| 4 | YFS | Blood | XPO7 | 0.02 | 0.01 | lasso | 3 | 0.01 | 4.0e-04 | -7.1 | 6.8 | 9.2e-12 | 0.55 | 0.19 | 0.20 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STC1 | 0.04 | 0.05 | enet | 7 | 0.06 | 8.9e-12 | -8.1 | 7.8 | 4.7e-15 | 0.04 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHMP7 | 0.03 | 0.03 | blup | 89 | 0.01 | 3.8e-02 | 2.0 | -5.3 | 1.3e-07 | -0.01 | 0.06 | 0.10 | FALSE |