Hub : Genes

TPH1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1230 0.0370 2.0e-06 0.075 0.063 0.070 0.079 0.074 1.8e-09 4.0e-08 6.4e-09 8.0e-10 2.6e-09
2 NTR Blood 0.0143 0.0074 2.1e-02 0.000 0.004 0.002 0.005 0.002 3.5e-01 1.1e-02 7.9e-02 7.1e-03 7.5e-02
3 TCGA Skin Cutaneous Melanoma 0.2450 0.1290 9.3e-03 -0.005 -0.006 0.046 NA 0.043 4.6e-01 5.0e-01 2.3e-02 NA 2.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.1 3.4 5.2 -1.8 2.3 -1.2
Bipolar Disorder or Schizophrenia 3.5 8.5 10.5 -2.9 3.2 -2.6
Depressed Affect (Nagel 2018) 0.7 1.5 2.7 1.2 1.6 -0.6
Depression (Nagel 2018) 0.7 1.0 2.6 1.6 -0.4 0.5
Intelligence (Savage-Jansen 2018) 1.3 4.1 7.9 2.8 0.8 1.9
Neuroticism (Nagel 2018) 0.5 1.1 2.1 1.5 1.1 -0.2
Schizophrenia (2018) 2.6 5.3 5.7 -2.2 2.4 -2.3
Schizophrenia vs Biploar Disorder 1.7 2.2 5.2 1.1 -2.3 0.6
Worry (Nagel 2018) 0.4 0.8 1.5 0.1 -1.0 -1.2
Alzheimer’s Disease (in mother) 0.7 0.8 1.8 0.4 0.7 -1.3
Alzheimer’s Disease (in father) 1.3 1.4 2.5 -1.3 1.6 0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 1.3 -0.2 1.1 -0.6
Crohns Disease (2017) 0.3 0.6 1.2 -1.1 0.6 0.5
Irritable Bowel Disease (IBD) 0.5 1.2 2.4 -1.0 1.6 -0.5
Ulcerative Colitis (UC) 1.1 2.1 2.7 -1.2 1.5 -1.6
Major Depression (MDD) 0.6 0.7 1.6 0.7 -1.3 0.2
Reaction Time 3.6 6.9 14.7 -3.8 -1.1 -2.2
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.1 1.4 0.9 1.0
Breast Cancer 0.4 1.0 2.3 0.3 -1.5 -0.9
Ovarian Cancer 1.2 1.6 4.3 -2.1 -0.6 -0.3
Prostate Cancer 0.6 0.8 1.7 1.3 -0.5 -0.6
Age at First Birth 0.9 1.3 3.1 -0.4 1.8 0.8
Bipolar Disorder (2011) 2.0 2.0 2.9 -1.7 1.0 -1.4
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 0.5 0.1 0.2
Coronary Artery Disease (CAD) 0.9 1.0 2.4 0.7 -1.5 -0.5
Crohns Disease (2012) 0.5 0.8 1.2 -1.1 0.6 -0.9
Mean Putamen Volume 0.2 0.3 0.4 -0.6 0.1 0.6
Fasting Glucose 1.7 2.0 4.3 1.2 0.5 2.1
HbA1C 0.8 0.9 1.4 0.8 0.8 1.2
HDL Cholesterol 0.6 1.1 1.8 -1.3 0.1 -1.2
LDL Cholesterol 1.1 1.8 2.9 -0.9 1.7 1.3
Lupus 0.4 0.6 1.3 1.2 0.4 0.5
Neuroticism (2016) 2.8 4.0 5.9 2.4 2.3 1.0
Primary Biliary Cirrhosis 0.7 1.0 1.4 -0.9 0.9 -1.2
Rheumatoid Arthritis 0.5 0.7 1.0 -0.9 1.0 0.5
Schizophrenia (2014) 1.4 3.1 4.9 -1.4 2.2 -1.5
Triglycerides 1.9 3.1 5.0 2.2 -0.9 1.9
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.2 0.9 -1.1 -0.1
Ulcerative Colitis 0.6 0.9 2.0 -0.3 1.4 -0.8
Blood Eosinophil Count 0.5 4.2 7.2 2.3 0.2 2.7
Blood Platelet Count 0.5 5.7 9.1 2.8 -3.0 0.3
Blood Red Count 0.2 1.5 2.3 1.5 0.6 1.3
Blood White Count 1.5 11.3 21.7 4.7 -3.3 1.2
Heel T-Score 0.3 2.1 5.0 1.0 -2.2 -0.4
BMI 1.2 6.8 13.8 2.5 0.4 3.7
Height 1.2 22.9 37.0 -6.1 3.9 -4.1
Waist Hip Ratio (WHR) 0.2 0.9 2.6 1.6 -0.4 0.3
Systolic Blood Pressure 0.4 1.8 5.2 0.2 -2.3 -0.2
Smoking Status 1.1 2.6 3.3 1.8 -1.8 -1.0
Allergy or Eczema 1.4 3.6 6.0 1.2 2.4 1.8
Cardiovascular Disease 0.4 1.3 2.5 1.6 -1.0 0.5
Hypothyroidism (self reported) 0.2 0.4 1.0 -0.5 1.0 0.3
Respiratory disease 0.2 0.4 1.2 1.1 -0.3 0.3
Type 2 Diabetes (T2D) (2018) 1.3 2.4 4.3 1.4 -1.0 2.1
Lung FEV1/FVC ratio 0.5 2.7 7.0 0.4 -2.6 -1.0
Lung FVC 0.6 3.0 7.7 -0.6 2.8 1.0
Neuroticism 0.5 1.3 3.5 1.9 0.6 0.2
Chronotype (morning person) 0.2 0.4 1.3 0.1 1.1 0.2
Hair Pigment 0.0 1.0 2.8 1.7 0.1 0.4
Tanning 0.0 0.2 0.4 0.0 -0.3 -0.6
Hand grip strength (left) 0.1 0.1 0.2 -0.3 -0.4 -0.4
Number of treatments/medications taken 1.7 3.1 3.5 1.8 -1.6 1.9
Average weekly spirits intake 1.4 1.7 3.9 2.0 -0.3 1.1
Sensitivity / hurt feelings 1.4 2.4 3.9 2.0 -1.8 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.2 1.1 0.1 -0.5
Hearing difficulty/problems: Yes 1.3 2.0 4.4 2.1 0.0 1.3
Relative age of first facial hair 0.5 1.0 2.0 -0.8 0.5 -1.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 -0.2 0.3 0.4
Ever used hormone-replacement therapy (HRT) 3.5 4.4 8.4 2.9 -0.6 2.1
Ever had hysterectomy (womb removed) 2.3 2.6 4.2 2.0 -0.5 1.8
Systolic blood pressure, automated reading 1.1 3.3 8.1 0.7 -2.9 1.1
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 2.7 1.2 -1.0 1.6
Angina 2.9 3.8 5.9 2.3 -2.4 0.2
Medication for hormone replacement therapy 0.8 0.9 1.4 0.9 -0.7 1.2
Vitamin and mineral supplements 0.1 0.1 0.3 0.1 0.4 -0.5
Supplements: Zinc 0.7 0.8 1.2 1.1 -1.1 -0.2
Medication: Co-codamol 3.1 3.5 7.5 0.8 -1.6 2.7
Medication: Metformin 0.5 0.7 1.6 -0.0 -1.3 0.7
Diabetes (father) 0.5 0.6 1.6 -1.3 -0.3 -0.2
Diabetes (mother) 0.2 0.2 0.7 -0.8 0.0 -0.1
Severe depression (siblings) 0.0 0.0 0.1 -0.2 -0.3 -0.0
Pack years adult smoking proportion 0.3 0.4 0.9 -0.1 -0.5 -0.9
Impedance of leg (right) 0.1 0.6 0.9 0.7 -0.6 -1.0
Leg fat-free mass (left) 0.8 4.1 7.2 -2.7 2.0 -0.9
Trunk fat percentage 0.2 0.9 2.4 1.6 -0.5 0.2
Hand grip strength (right) 0.1 0.3 0.8 0.2 -0.9 0.4
Townsend deprivation index at recruitment 0.2 0.3 0.6 0.7 0.8 -0.0
Current tobacco smoking 0.9 1.4 4.1 2.0 -0.4 0.3
Average weekly fortified wine intake 1.2 1.4 4.0 0.4 2.0 0.0
Maternal smoking around birth 3.4 4.9 10.3 2.1 -3.2 0.3
Fed-up feelings 0.5 1.0 2.3 1.5 0.7 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.5 1.2 -0.0 0.4
Relative age voice broke 0.4 0.5 0.8 -0.5 0.8 -0.9
Taking other prescription medications 1.2 1.9 3.8 2.0 -0.7 1.1
Age when periods started (menarche) 1.1 2.6 3.8 -1.5 1.3 -1.9
Bilateral oophorectomy (both ovaries removed) 6.9 7.9 17.3 4.2 -0.1 2.5
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 3.6 -0.3 -1.4 -1.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.3 1.1 0.2 0.4
Qualifications: CSEs or equivalent 1.9 2.5 6.3 1.0 -2.5 -0.5
Serious illness, injury or assault to yourself 0.2 0.2 0.5 0.2 0.7 0.4
High blood pressure 0.6 1.8 2.8 1.7 -1.4 0.7
Hayfever, allergic rhinitis or eczema 2.8 6.1 8.7 1.9 2.4 3.0
Multivitamins +/- minerals 0.2 0.2 0.3 0.2 -0.5 0.6
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.2 -0.5 -0.5
Supplements: Glucosamine 1.7 2.2 2.7 1.6 -1.2 1.5
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.3 0.7 1.5 0.2
Medication: Atenolol 0.3 0.3 0.5 0.7 -0.2 0.7
Medication: Levothyroxine sodium 0.5 0.8 1.9 0.6 1.4 0.5
Sitting height 2.7 19.1 37.9 -6.2 3.2 -3.0
Chronic bronchitis/emphysema (father) 0.4 0.5 1.0 1.0 -0.6 0.3
High blood pressure (mother) 3.2 4.5 9.1 -3.0 0.3 -2.0
Body mass index (BMI) 0.5 2.3 3.6 1.7 -0.4 1.9
Impedance of leg (left) 0.1 0.4 0.9 0.9 -0.1 -0.5
Leg predicted mass (left) 0.8 4.0 6.9 -2.6 2.0 -1.0
Trunk fat mass 0.0 0.1 0.2 0.5 -0.0 -0.2
Waist circumference 0.2 0.7 1.0 1.0 0.1 1.0
Number of incorrect matches in round 1.9 3.2 8.8 0.8 -3.0 -0.2
Past tobacco smoking 0.5 0.8 2.2 -1.5 0.3 0.5
Alcohol usually taken with meals 1.6 2.7 5.6 -2.4 -0.5 -1.5
Nervous feelings 1.3 2.4 3.1 -1.3 -1.5 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.5 1.9 0.8 0.3
Hearing difficulty/problems with background noise 0.5 0.8 1.1 1.1 0.8 0.8
Hair/balding pattern: Pattern 2 0.5 0.7 1.6 -0.1 0.7 -1.2
Had menopause 3.6 4.5 6.0 1.9 -2.5 2.0
Had other major operations 0.3 0.3 0.9 0.9 -0.4 0.2
Forced vital capacity (FVC) 1.7 6.5 11.4 -2.7 3.4 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.2 0.3 -1.3 -1.5
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.2 0.2 1.5 -0.7
Qualifications: None of the above 0.2 0.4 0.8 0.6 -0.3 0.9
Financial difficulties in last 2 years 0.8 1.0 2.3 0.9 0.2 1.5
Mouth/teeth dental problems 1.0 1.6 3.6 0.2 1.9 1.0
Heart attack 0.4 0.6 1.6 1.3 0.1 0.3
Allergy 2.3 5.3 8.3 -2.2 -1.6 -2.9
Pain all over the body in last month 0.8 0.9 2.4 -0.0 0.4 1.6
Diabetes (self-reported) 0.4 0.6 1.0 0.2 -0.9 1.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.3 -0.4 0.9 -1.1
Medication: Ramipril 0.4 0.5 1.2 -1.1 0.1 -0.4
Medication: Simvastatin 0.3 0.4 0.7 -0.8 -0.8 -0.2
Fluid intelligence score 0.9 1.8 2.0 1.4 1.4 1.2
Illnesses of siblings 1.6 2.3 3.6 -1.9 -0.3 -1.8
Neuroticism score 0.2 0.4 0.5 0.7 -0.5 -0.5
Weight 0.2 0.9 1.7 -1.1 1.3 -0.1
Impedance of arm (right) 1.1 5.0 13.5 -1.2 -0.3 -3.7
Arm fat percentage (right) 0.3 1.0 2.4 1.6 -0.8 0.2
Trunk fat-free mass 1.2 6.7 12.7 -3.6 2.6 -0.8
Hip circumference 0.0 0.1 0.2 -0.4 0.5 0.1
Time employed in main current job 1.7 2.0 4.3 -0.9 0.9 -2.1
Alcohol intake versus 10 years previously 1.0 1.6 2.3 1.4 -0.6 1.5
Father’s age at death 0.3 0.4 1.0 -1.0 0.2 -0.4
Worrier / anxious feelings 0.7 1.3 1.9 1.1 -1.4 -1.0
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.5 6.9 2.6 0.3 2.6
Falls in the last year 0.2 0.3 0.4 -0.6 0.4 0.4
Hair/balding pattern: Pattern 3 1.0 1.4 3.5 -0.8 -1.9 -0.1
Number of live births 1.5 2.2 4.7 -1.0 2.2 -0.9
Forced expiratory volume in 1-second (FEV1) 1.2 3.9 5.6 -2.2 2.4 -1.1
Pulse rate 0.7 1.1 1.6 1.2 0.6 1.3
Happiness 0.2 0.2 0.5 0.7 -0.0 -0.4
Noisy workplace 0.8 1.0 1.2 1.1 -0.9 0.9
Qualifications: A levels/AS levels or equivalent 1.3 3.0 4.7 -2.2 2.1 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.4 0.3 0.5 0.7
Mouth/teeth dental problems: Dentures 1.0 1.7 2.6 1.5 -1.6 -0.4
Asthma 0.4 0.8 1.3 1.0 0.3 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 0.7 0.8 0.9 -0.6
Medication: Cholesterol lowering 0.7 1.1 3.1 -0.5 -1.8 0.1
Depression (self-reported) 0.7 0.8 2.0 -0.6 -1.4 -0.1
Medication: Lansoprazole 1.0 1.1 1.7 0.5 1.3 1.1
Prospective memory result 1.1 1.3 2.1 -0.8 1.4 1.1
Lung cancer (father) 2.9 3.4 6.4 -1.8 0.8 -2.5
Illnesses of mother 0.8 0.9 2.4 1.6 -0.1 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.4 13.3 -3.6 1.6 -1.9
Pulse wave Arterial Stiffness index 0.7 0.8 2.5 0.3 -1.6 0.1
Impedance of arm (left) 1.0 4.4 11.8 -0.8 -0.9 -3.4
Arm fat mass (right) 0.0 0.1 0.3 0.5 -0.1 0.3
Trunk predicted mass 1.2 6.6 12.3 -3.5 2.6 -0.7
Standing height 2.1 21.0 33.9 -5.8 3.7 -3.9
Length of working week for main job 0.9 1.0 2.1 1.0 1.4 -0.2
Exposure to tobacco smoke at home 0.4 0.5 1.3 0.4 -1.1 -0.0
Breastfed as a baby 0.7 0.9 1.7 -0.9 0.4 -1.3
Tense / ‘highly strung’ 0.5 0.9 1.3 -0.9 0.7 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 3.8 1.8 -1.9 0.1
Hair/balding pattern: Pattern 4 1.6 3.8 6.1 2.5 1.9 1.4
Birth weight of first child 1.0 1.9 3.5 -1.9 1.4 -0.4
Peak expiratory flow (PEF) 0.4 0.9 1.4 -1.1 0.3 -1.2
Pulse wave reflection index 0.3 0.4 0.7 0.2 -0.9 -0.6
Ever highly irritable/argumentative for 2 days 1.8 2.2 2.6 1.6 1.5 1.3
Loud music exposure frequency 0.9 0.9 2.4 -1.6 0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 -0.6 -0.5 0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 -0.3 -0.4 0.4
Blood clot in the leg (DVT) 1.7 2.2 4.9 1.2 -0.5 2.2
Medication: Paracetamol 0.5 0.8 1.3 0.6 -0.8 -1.1
Headache pain in last month 0.4 0.7 1.6 1.3 0.2 -0.5
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 5.3 0.2 2.3 0.1
Glaucoma (self-reported) 0.7 0.8 1.0 0.8 1.0 1.0
Gout (self-reported) 0.8 1.1 1.6 -1.1 -1.3 -0.8
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.2 -0.2 1.5 0.2
Medication: Amlodipine 4.2 5.9 8.9 3.0 -0.1 3.0
Medication: Ventolin 100micrograms inhaler 1.1 1.5 3.0 1.7 0.6 1.0
Birth weight 1.1 2.4 6.2 -2.5 -0.2 -1.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 0.7 -0.8 0.0
High blood pressure (siblings) 2.1 3.0 4.3 2.0 0.9 2.1
Forced vital capacity (FVC), Best measure 1.8 6.7 11.2 -3.3 2.6 -1.4
Body fat percentage 0.4 1.7 3.6 1.9 -1.0 0.5
Leg fat percentage (right) 0.8 2.8 5.4 2.3 -1.2 1.3
Arm fat-free mass (right) 0.6 3.2 5.0 -2.0 2.2 0.7
Exposure to tobacco smoke outside home 1.7 2.3 3.7 1.9 -0.9 1.5
Comparative body size at age 10 1.3 3.6 4.7 1.9 1.6 2.2
Number of full brothers 0.4 0.5 1.5 -1.2 0.3 0.0
Worry too long after embarrassment 0.4 0.6 1.3 0.7 -0.3 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 2.0 3.9 -0.6 -2.0 -1.3
Wheeze or whistling in the chest in last year 0.8 1.4 2.5 1.2 1.6 0.4
Number of children fathered 1.0 1.2 2.2 -1.5 0.4 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 2.0 -0.5 -1.4 -0.2
Age at first live birth 0.5 0.9 2.5 -0.5 1.6 0.2
Pulse wave peak to peak time 0.8 1.0 2.4 -0.7 1.5 -0.4
Health satisfaction 0.4 0.5 0.8 0.9 -0.8 0.4
Shortness of breath walking on level ground 1.8 2.2 5.0 2.2 -0.7 1.0
Qualifications: College or University degree 0.3 0.9 2.3 -1.5 0.5 0.2
Eye problems/disorders: None of the above 0.2 0.2 0.4 0.1 0.5 0.6
Mouth/teeth dental problems: Loose teeth 1.3 1.6 3.3 1.2 -1.8 -0.2
Emphysema/chronic bronchitis 0.3 0.3 0.6 -0.6 -0.0 -0.8
Medication for pain relief, constipation, heartburn 0.4 0.7 1.2 -1.1 0.9 0.2
Neck or shoulder pain in last month 2.4 3.4 5.3 2.3 -0.7 2.1
Medication: Blood pressure 0.8 1.4 4.1 -0.4 -2.0 0.1
Angina (self-reported) 3.3 4.4 7.5 2.3 -2.7 0.4
Migraine (self-reported) 0.1 0.1 0.1 0.3 0.2 -0.3
Medication: Ibuprofen 0.1 0.2 0.2 0.5 0.2 -0.5
Medication: Allopurinol 0.4 0.5 0.9 -0.9 0.9 0.0
Medication: Omeprazole 1.7 2.0 2.8 0.8 1.6 1.7
Medication: Seretide 50 evohaler 2.1 2.4 4.9 -0.5 -1.4 -2.2
Mean time to correctly identify matches 2.9 5.4 9.6 -3.1 -1.8 -1.8
Heart disease (mother) 0.5 0.7 1.3 1.1 -0.1 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.6 4.0 2.0 -1.9 0.5
Whole body fat mass 0.1 0.2 0.5 0.7 -0.3 0.3
Leg fat mass (right) 0.1 0.4 0.7 0.9 -0.4 0.4
Arm predicted mass (right) 0.6 3.2 4.9 -2.0 2.2 0.6
Pulse rate, automated reading 1.5 5.0 11.0 3.3 -0.5 1.9
Alcohol intake frequency. 0.9 2.1 3.3 1.5 -0.8 1.8
Comparative height size at age 10 1.2 6.5 8.7 -3.0 3.0 -1.5
Number of full sisters 2.1 2.5 6.6 -2.6 0.7 -0.7
Suffer from ‘nerves’ 1.5 2.3 3.7 -1.6 -1.0 -1.9
Overall health rating 2.6 5.5 11.8 3.4 -0.1 2.2
Chest pain or discomfort 3.3 4.8 8.6 2.9 -0.4 2.3
Had major operations 1.1 1.3 2.3 1.2 0.4 1.5
Age at last live birth 0.1 0.2 0.2 -0.5 0.5 0.3
Family relationship satisfaction 0.6 0.7 1.4 -1.2 -0.2 -0.8
Leg pain on walking 0.8 1.0 1.8 0.9 -1.3 0.6
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.9 3.4 -0.0 -1.5 -1.9
Commuting to job workplace: Car/motor vehicle 1.0 1.2 1.6 1.1 1.3 0.8
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.6 -1.0 0.0 -1.6
Medication: Aspirin 0.4 0.6 1.6 0.4 -1.2 -0.1
Supplements: Vitamin C 0.7 0.9 2.4 0.4 -1.6 0.2
Knee pain experienced in last month 1.4 2.2 6.6 2.6 0.3 0.2
Hypertension (Self-reported) 0.4 1.2 2.1 1.4 -1.2 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 4.1 1.0 2.0 1.1
Illnesses of father: Heart disease 1.1 1.5 2.9 1.7 -0.1 1.3
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.1 0.1 0.6
Smoking status: Previous 0.7 1.1 2.7 0.5 -0.6 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 5.7 -2.4 0.9 -0.3
Whole body fat-free mass 1.0 5.8 10.1 -3.2 2.6 -0.6
Leg fat-free mass (right) 0.9 4.6 7.0 -2.6 2.5 -0.8
Arm fat percentage (left) 0.4 1.5 3.0 1.7 -1.1 0.5
Average weekly red wine intake 0.8 1.2 2.7 -0.8 1.6 -0.4
Handedness (chirality/laterality): Left-handed 2.9 3.5 5.5 -2.4 0.8 -2.1
Mood swings 0.3 0.6 1.0 0.6 1.0 -0.8
Loneliness, isolation 0.5 0.7 1.0 1.0 0.9 0.6
Long-standing illness, disability or infirmity 2.1 3.2 6.7 1.5 -2.6 0.9
Ever had bowel cancer screening 1.6 1.9 3.0 1.4 -1.7 0.8
Diabetes diagnosed by doctor 1.0 1.6 3.2 0.7 -1.8 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 -0.7 -0.3 -0.6
Friendships satisfaction 0.2 0.2 0.4 0.6 -0.6 0.2
Qualifications: nursing, teaching 0.3 0.4 0.7 0.6 0.4 0.9
Commuting to job workplace: Walk 0.1 0.1 0.4 0.1 0.2 -0.6
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.3 0.3 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.9 -0.2 -1.4 -0.3
Medication for cholesterol 0.9 1.3 2.9 -1.7 -0.2 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.0 0.1 -1.1 -1.4
Back pain experienced in last month 1.1 1.6 2.5 -1.5 -0.0 -1.6
Mineral and other dietary supplements 1.0 1.4 2.0 -1.4 1.3 -0.7
Breast cancer (self-reported) 0.7 0.8 1.3 -1.1 0.9 0.5
Asthma (self-reported) 0.4 0.8 1.4 1.2 0.0 1.0
Osteoporosis (self-reported) 1.1 1.3 2.8 -1.7 -1.1 -0.2
Osteoarthritis (self-reported) 1.7 2.3 4.2 1.6 -0.5 2.0
Medication: Aspirin 0.6 0.8 2.3 0.2 -1.5 -0.2
Medication: Gliclazide 0.8 1.0 2.2 -0.3 1.5 0.7
Illnesses of father: None of the above (group 1) 0.7 0.9 2.3 -0.5 -0.0 -1.5
Smoking status: Current 1.0 1.5 4.4 2.1 -0.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.8 -1.3 1.2 -0.1
Whole body water mass 0.9 5.4 9.5 -3.1 2.5 -0.6
Leg predicted mass (right) 0.9 4.6 7.1 -2.7 2.5 -0.8
Arm fat mass (left) 0.1 0.4 0.8 0.9 -0.3 0.5
Number of self-reported non-cancer illnesses 1.8 3.1 5.2 2.3 -2.0 0.4
Average weekly champagne plus white wine intake 0.5 0.7 2.0 -0.4 1.4 0.0
Miserableness 0.4 0.7 1.2 1.1 1.0 -0.1
Guilty feelings 0.4 0.6 1.1 1.0 0.2 0.9
Wears glasses or contact lenses 3.1 3.6 6.2 1.4 -1.6 2.5
Ever taken oral contraceptive pill 1.1 1.2 3.1 0.7 1.8 0.4
Hearing aid user 5.4 6.1 12.4 3.5 1.9 1.6
Mother’s age at death 0.7 0.9 1.6 -1.0 1.3 -0.3
Financial situation satisfaction 0.2 0.2 0.5 0.7 0.3 -0.1
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.5 0.9 -1.2 0.8
Commuting to job workplace: Public transport 2.8 3.4 5.7 -2.4 -0.8 -1.9
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 -0.2 0.5 0.7
Medication: Blood pressure 0.9 1.6 3.5 1.9 0.1 1.2
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.9 0.5 -1.7 -0.7
Supplements: Fish oil (including cod liver oil) 2.1 2.7 5.5 2.3 -1.4 0.7
High cholesterol (Self-reported) 0.3 0.5 1.4 -1.2 0.2 -0.0
Medication: Bendroflumethiazide 2.2 3.3 7.9 2.8 -0.4 1.4
Medication: Paracetamol 0.9 1.4 2.5 1.6 -1.2 0.5
Medication: Lisinopril 0.5 0.6 1.0 -1.0 0.4 -0.8
Medication: Atorvastatin 0.5 0.6 0.8 0.9 -0.8 0.6
Illnesses of father: High blood pressure 0.3 0.4 0.9 -0.1 0.6 1.0
Alcohol drinker status: Never 0.3 0.3 0.5 0.5 -0.7 -0.4
Ever smoked 0.8 1.4 3.7 1.9 -0.3 0.6
Basal metabolic rate 0.8 4.3 7.1 -2.7 2.3 -0.5
Leg fat percentage (left) 0.9 3.1 6.2 2.5 -0.9 1.5
Arm fat-free mass (left) 0.6 3.2 5.2 -2.0 2.3 0.5
Number of operations (self-reported) 1.6 2.4 4.5 2.1 -1.0 1.3
Average weekly beer plus cider intake 0.7 0.9 1.7 1.3 0.3 1.0
Irritability 0.5 0.8 2.1 -0.1 1.4 -0.5
Risk taking 1.0 1.5 2.7 -1.6 0.9 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.9 -0.6 -1.4 0.4
Fractured/broken bones in last 5 years 0.4 0.6 1.5 -0.4 -1.2 0.2
Age started oral contraceptive pill 2.1 2.6 4.0 2.0 -0.5 1.9
Diastolic blood pressure, automated reading 0.5 1.6 3.6 0.3 -1.9 1.0
Ever depressed for a whole week 1.7 2.1 3.8 -1.3 -0.9 -1.9
Unable to work because of sickness or disability 0.2 0.2 0.5 0.7 0.1 0.5
Commuting to job workplace: Cycle 0.6 0.7 1.5 -0.6 -1.2 0.4
Myopia 1.6 2.3 5.1 -1.0 -2.3 -1.0
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.0 -1.7 1.7 0.1
Cholesterol lowering medication 0.7 1.1 2.2 1.5 0.5 0.9
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 2.4 0.9 1.5 1.4
Pain experienced in last month 0.3 0.5 0.8 -0.9 0.6 -0.4
Supplements: Calcium 0.1 0.1 0.1 -0.2 0.4 0.4
Basal cell carcinoma (self-reported) 0.3 0.4 0.6 0.6 -0.4 -0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.1 1.5 -0.4 0.3
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 5.2 1.2 -0.5 2.3
Heart disease (siblings) 1.0 1.2 3.6 0.1 -1.9 0.4
Alcohol drinker status: Previous 1.0 1.2 3.0 1.7 -0.0 0.8
Pack years of smoking 0.4 0.6 1.3 -0.2 -0.8 -1.1
Impedance of whole body 0.3 1.7 5.0 0.0 -0.3 -2.2
Leg fat mass (left) 0.1 0.4 0.8 0.9 -0.3 0.6
Arm predicted mass (left) 0.7 3.5 5.9 -2.1 2.4 0.6