Hub : Genes

FASN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0423	0.0176	0.00076	0.048	NA	0.033	NA	0.031	1.6e-05	NA	3.1e-04	NA	5.1e-04
2	GTEx	Whole Blood	0.0600	0.0280	0.00190	-0.001	NA	0.010	NA	0.003	3.8e-01	NA	4.0e-02	NA	1.6e-01
3	YFS	Blood	0.0842	0.0186	0.00000	0.086	0.123	0.130	NA	0.132	1.3e-26	5e-38	2.3e-40	NA	4.8e-41

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	1.6	0.9	1.3	-0.0
Bipolar Disorder or Schizophrenia	1.1	2.6	3.6	1.9	1.8	-1.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.0	0.1	-1.4	-0.5
Depression (Nagel 2018)	0.7	1.0	1.7	0.6	-1.3	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.5	-1.6	1.2	1.3
Neuroticism (Nagel 2018)	0.7	1.5	2.8	1.0	-1.0	-1.7
Schizophrenia (2018)	1.0	2.0	3.0	1.7	1.2	-1.2
Schizophrenia vs Biploar Disorder	1.0	1.3	2.2	1.5	-0.2	-1.3
Worry (Nagel 2018)	0.8	1.7	3.1	1.4	0.2	-1.8
Alzheimer’s Disease (in mother)	3.2	3.8	5.5	-1.9	1.4	2.3
Alzheimer’s Disease (in father)	0.4	0.5	1.0	-0.5	1.0	0.4
Alzheimer’s Disease (including proxy)	2.1	3.1	3.8	-1.5	1.8	1.9
Crohns Disease (2017)	0.1	0.2	0.2	0.3	0.5	-0.5
Irritable Bowel Disease (IBD)	0.1	0.4	0.7	0.5	-0.3	-0.8
Ulcerative Colitis (UC)	0.2	0.5	0.7	0.3	-0.8	-0.8
Major Depression (MDD)	2.7	3.2	5.1	2.3	0.0	-2.1
Reaction Time	0.8	1.5	2.7	1.6	-0.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.5	-0.9	0.0
Breast Cancer	0.7	1.8	4.2	0.7	-2.1	-0.8
Ovarian Cancer	0.3	0.4	1.0	-0.4	1.0	0.1
Prostate Cancer	3.5	4.9	7.7	-0.8	2.8	2.5
Age at First Birth	1.2	1.8	2.2	-1.5	1.5	1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	8.2	11.2	13.9	-2.9	3.7	3.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.2
Crohns Disease (2012)	0.3	0.4	0.8	0.6	0.1	-0.9
Mean Putamen Volume	1.0	1.1	3.2	0.1	-1.8	-0.4
Fasting Glucose	0.1	0.1	0.2	-0.0	-0.4	-0.4
HbA1C	2.0	2.2	4.5	-0.5	2.1	1.4
HDL Cholesterol	1.2	2.0	3.0	-1.7	0.9	1.5
LDL Cholesterol	1.7	2.6	3.7	-1.1	1.7	1.9
Lupus	0.1	0.1	0.2	0.1	-0.2	-0.5
Neuroticism (2016)	2.1	3.1	5.1	0.9	-2.3	-1.8
Primary Biliary Cirrhosis	1.8	2.6	3.0	1.7	-1.6	-1.5
Rheumatoid Arthritis	1.3	1.8	3.7	0.6	-1.9	-1.2
Schizophrenia (2014)	1.4	3.1	5.3	2.3	1.3	-1.5
Triglycerides	1.9	3.1	4.2	-1.4	1.8	2.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	0.0	0.0	1.4
Ulcerative Colitis	0.5	0.7	1.1	0.5	-0.8	-1.0
Blood Eosinophil Count	1.3	10.1	12.0	-3.4	2.6	3.5
Blood Platelet Count	0.1	1.5	4.1	0.5	-2.0	0.5
Blood Red Count	0.1	0.9	1.2	-1.1	-1.0	-0.7
Blood White Count	0.1	0.6	1.1	0.9	-1.1	-0.1
Heel T-Score	0.3	2.3	4.0	-1.7	2.0	-0.1
BMI	3.0	17.3	26.0	-5.1	1.0	5.0
Height	2.3	43.5	55.7	6.5	-5.7	-7.5
Waist Hip Ratio (WHR)	0.7	3.0	6.8	-2.6	0.5	1.4
Systolic Blood Pressure	0.1	0.3	0.7	0.4	0.8	-0.1
Smoking Status	1.3	3.1	4.9	-2.0	0.7	2.2
Allergy or Eczema	1.8	4.9	9.4	-3.1	-0.1	2.3
Cardiovascular Disease	0.1	0.4	0.5	-0.7	0.6	0.7
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.4	0.4	0.8
Respiratory disease	0.2	0.4	0.6	0.8	-0.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.2	-0.3	-0.2
Lung FEV1/FVC ratio	0.2	0.8	1.3	-1.2	-0.1	1.0
Lung FVC	1.3	6.7	10.0	2.6	-1.7	-3.2
Neuroticism	0.0	0.0	0.1	-0.1	-0.2	-0.2
Chronotype (morning person)	0.5	1.1	2.0	0.9	-0.8	-1.4
Hair Pigment	0.1	1.7	3.6	1.2	1.9	0.1
Tanning	0.0	0.1	0.2	0.2	-0.4	0.4
Hand grip strength (left)	0.6	1.5	1.9	-1.3	1.4	1.0
Number of treatments/medications taken	0.2	0.3	0.6	-0.1	-0.8	0.6
Average weekly spirits intake	0.1	0.1	0.1	-0.3	0.4	0.2
Sensitivity / hurt feelings	1.3	2.3	3.5	1.5	-1.1	-1.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.0	1.0	-1.1	-1.4
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.4	-0.5	-0.4
Relative age of first facial hair	0.3	0.6	1.0	0.7	1.0	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.3	0.6	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.8	0.4	-0.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.7	-0.1	0.6
Systolic blood pressure, automated reading	0.8	2.3	3.2	-1.4	1.8	1.3
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.1	0.2	0.1
Angina	1.6	2.1	4.8	0.7	-2.2	-1.1
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	0.3	-0.5
Vitamin and mineral supplements	2.7	3.7	5.1	-2.1	1.3	2.3
Supplements: Zinc	0.7	0.7	1.2	0.3	-1.0	-1.1
Medication: Co-codamol	1.3	1.5	2.3	-1.1	-1.5	1.0
Medication: Metformin	0.2	0.3	0.4	-0.3	-0.6	0.6
Diabetes (father)	0.3	0.4	0.6	0.7	-0.1	-0.7
Diabetes (mother)	0.0	0.0	0.0	-0.1	0.0	0.1
Severe depression (siblings)	1.5	1.7	3.2	1.4	-0.1	-1.8
Pack years adult smoking proportion	0.4	0.6	1.0	-1.0	0.0	0.9
Impedance of leg (right)	0.9	4.4	8.7	2.1	-0.6	-2.9
Leg fat-free mass (left)	0.3	1.4	4.0	0.5	-2.0	-0.2
Trunk fat percentage	0.4	1.8	3.8	-2.0	-0.4	1.2
Hand grip strength (right)	0.2	0.6	1.5	-0.3	1.2	0.5
Townsend deprivation index at recruitment	1.0	1.5	1.6	1.3	-1.3	-1.1
Current tobacco smoking	0.1	0.2	0.3	0.6	-0.6	0.0
Average weekly fortified wine intake	0.8	0.9	1.7	-1.3	0.3	1.0
Maternal smoking around birth	1.1	1.5	3.9	-0.2	2.0	0.8
Fed-up feelings	0.1	0.2	0.5	-0.3	-0.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.0	0.7	-1.0	-1.0
Relative age voice broke	0.1	0.1	0.2	-0.0	0.5	0.2
Taking other prescription medications	0.7	1.0	1.3	-0.6	-1.2	1.1
Age when periods started (menarche)	1.5	3.5	5.4	2.3	-1.2	-1.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.7	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	0.9	-0.9	1.0	0.7
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	3.2	1.8	-0.7	-1.8
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.9	0.5	0.1
Serious illness, injury or assault to yourself	1.4	1.7	2.2	1.2	-1.5	-1.2
High blood pressure	0.7	2.0	2.6	-1.6	1.3	1.3
Hayfever, allergic rhinitis or eczema	1.2	2.5	5.0	-2.2	-0.3	1.6
Multivitamins +/- minerals	0.6	0.8	1.1	0.8	-0.8	-1.1
Stomach or abdominal pain in last month	0.9	1.2	3.4	0.2	1.8	-0.3
Supplements: Glucosamine	0.2	0.3	0.5	0.5	-0.1	-0.7
Diverticular disease/diverticulitis (self-reported)	2.5	2.9	5.5	-2.3	0.8	1.6
Medication: Atenolol	0.3	0.3	0.8	-0.4	0.2	0.9
Medication: Levothyroxine sodium	1.8	3.1	3.7	-1.9	1.8	1.5
Sitting height	4.8	33.8	38.8	5.9	-6.2	-5.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.3	-0.0	0.3
High blood pressure (mother)	0.7	0.9	1.7	1.1	0.1	-1.3
Body mass index (BMI)	2.6	11.1	19.6	-4.4	0.6	3.7
Impedance of leg (left)	0.8	3.8	7.5	2.0	-0.2	-2.7
Leg predicted mass (left)	0.3	1.6	4.3	0.6	-2.1	-0.3
Trunk fat mass	0.4	1.8	3.3	-1.8	-0.9	1.0
Waist circumference	2.8	10.2	19.5	-4.4	-0.3	3.3
Number of incorrect matches in round	0.6	1.0	1.4	1.2	0.7	-1.0
Past tobacco smoking	2.9	5.2	7.8	2.7	-0.8	-2.8
Alcohol usually taken with meals	1.3	2.2	5.2	-2.3	-0.3	1.1
Nervous feelings	4.0	7.5	11.1	3.3	-0.8	-3.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	2.8	1.7	-1.0	-1.7
Hearing difficulty/problems with background noise	0.4	0.6	1.0	1.0	-0.4	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	0.6	-0.7	-0.5
Had menopause	1.5	1.8	4.0	-1.1	2.0	0.6
Had other major operations	0.4	0.5	1.6	0.1	1.3	0.1
Forced vital capacity (FVC)	4.4	17.0	21.2	4.0	-3.7	-4.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.0	-0.8	1.0	0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.4	0.5	0.3
Qualifications: None of the above	0.1	0.2	0.3	0.4	-0.6	-0.4
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.4	-0.9	0.0
Mouth/teeth dental problems	1.4	2.2	5.9	-0.3	2.4	0.8
Heart attack	1.4	1.8	4.6	0.6	-2.1	-0.6
Allergy	0.7	1.6	2.5	1.4	1.6	-0.7
Pain all over the body in last month	0.3	0.4	0.7	-0.3	0.8	0.6
Diabetes (self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.4	-0.8	-1.5	0.5
Medication: Ramipril	1.0	1.3	2.1	-1.4	0.2	1.5
Medication: Simvastatin	1.3	2.0	2.9	-1.4	1.0	1.7
Fluid intelligence score	0.2	0.3	0.8	-0.3	-0.9	-0.2
Illnesses of siblings	0.1	0.1	0.3	0.5	-0.3	0.3
Neuroticism score	0.3	0.6	1.0	0.4	-0.9	-1.0
Weight	0.4	2.0	2.9	-1.7	-1.4	1.0
Impedance of arm (right)	2.4	11.1	16.4	4.0	-1.0	-4.0
Arm fat percentage (right)	1.4	5.6	10.6	-3.3	-0.1	2.5
Trunk fat-free mass	0.1	0.8	2.2	0.3	-1.5	-0.3
Hip circumference	0.5	2.1	5.0	-0.9	-2.2	0.6
Time employed in main current job	0.7	0.8	1.3	0.1	-1.1	-1.1
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.8	-0.2	0.8
Father’s age at death	0.6	0.8	1.4	1.2	0.6	-0.8
Worrier / anxious feelings	0.1	0.2	0.4	-0.2	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	3.5	1.9	-1.3	-1.9
Falls in the last year	0.7	1.0	1.4	1.2	-1.0	-0.7
Hair/balding pattern: Pattern 3	0.7	1.0	2.6	-1.6	-0.2	0.6
Number of live births	2.2	3.1	4.3	2.1	-0.9	-2.1
Forced expiratory volume in 1-second (FEV1)	4.0	13.4	14.7	3.4	-3.7	-3.8
Pulse rate	0.5	0.9	1.4	0.9	-0.7	-1.2
Happiness	0.5	0.6	1.7	-0.3	1.3	0.4
Noisy workplace	0.3	0.4	0.8	0.6	-0.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.7	3.0	-1.7	0.3	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	-0.4	0.0
Mouth/teeth dental problems: Dentures	0.7	1.2	2.9	0.4	-1.7	-0.7
Asthma	0.6	1.1	3.0	0.5	-1.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	0.1	-1.2	-0.6
Medication: Cholesterol lowering	0.3	0.5	0.8	-0.5	-0.9	0.6
Depression (self-reported)	1.6	1.9	3.0	1.7	-0.2	-1.7
Medication: Lansoprazole	0.7	0.8	1.1	1.0	-1.0	-0.6
Prospective memory result	0.3	0.4	0.7	0.6	-0.5	-0.8
Lung cancer (father)	1.8	2.1	4.4	-2.1	0.3	1.4
Illnesses of mother	0.3	0.4	0.5	0.7	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.2	14.8	3.3	-3.3	-3.9
Pulse wave Arterial Stiffness index	0.5	0.6	0.9	-0.8	0.4	0.9
Impedance of arm (left)	2.9	13.6	20.8	4.6	-1.1	-4.3
Arm fat mass (right)	1.0	4.2	8.0	-2.8	-0.5	2.1
Trunk predicted mass	0.1	0.7	2.1	0.2	-1.5	-0.2
Standing height	2.9	28.4	34.3	5.9	-4.2	-5.7
Length of working week for main job	1.1	1.2	1.8	-1.0	1.0	1.3
Exposure to tobacco smoke at home	0.3	0.4	1.1	0.0	-1.1	-0.2
Breastfed as a baby	0.2	0.3	0.9	-0.1	0.9	-0.1
Tense / ‘highly strung’	0.3	0.6	1.0	-0.8	1.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	-1.1	0.6	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-0.5	-1.0	-0.4
Birth weight of first child	4.2	7.6	11.9	1.7	-3.4	-2.8
Peak expiratory flow (PEF)	0.5	1.2	1.9	1.4	-0.8	-1.1
Pulse wave reflection index	1.9	2.4	3.2	-1.8	0.9	1.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.5	-0.7	0.7	0.5
Loud music exposure frequency	2.1	2.3	2.8	1.6	-1.2	-1.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.2	-0.6	-0.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.2	0.4	-1.5	-1.3
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.9	-0.3	0.6
Medication: Paracetamol	0.1	0.2	0.4	0.1	-0.7	-0.1
Headache pain in last month	0.1	0.1	0.2	0.4	-0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.1	1.0	-0.6	-1.4
Glaucoma (self-reported)	0.3	0.3	0.7	0.4	-0.8	-0.2
Gout (self-reported)	3.8	5.2	6.9	-2.6	1.4	2.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	0.7	-0.8	0.9	0.7
Medication: Amlodipine	0.1	0.2	0.4	0.6	-0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.7	-0.5	0.3
Birth weight	1.0	2.1	3.1	1.3	-1.8	-1.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	0.3	0.3	-0.9
High blood pressure (siblings)	0.2	0.3	0.5	-0.0	0.7	-0.6
Forced vital capacity (FVC), Best measure	5.1	18.5	23.4	4.2	-3.8	-4.8
Body fat percentage	1.2	4.8	9.8	-3.1	-0.0	2.2
Leg fat percentage (right)	2.4	8.8	18.4	-4.3	0.1	2.9
Arm fat-free mass (right)	0.2	0.9	2.3	-0.4	-1.5	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.3	-0.6	0.0
Comparative body size at age 10	1.3	3.7	6.7	-2.6	0.3	2.0
Number of full brothers	2.3	2.9	3.6	1.7	-1.4	-1.9
Worry too long after embarrassment	1.3	2.3	3.4	1.3	-1.3	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.8	0.5	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	0.5	-0.9	-0.7
Number of children fathered	0.3	0.4	0.6	-0.6	-0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.1	-0.1	-0.1
Age at first live birth	0.6	1.0	1.6	-1.3	0.1	1.2
Pulse wave peak to peak time	1.3	1.5	2.1	1.4	-0.7	-1.5
Health satisfaction	0.4	0.5	0.9	1.0	-0.8	-0.1
Shortness of breath walking on level ground	4.4	5.3	5.9	2.4	-2.0	-2.4
Qualifications: College or University degree	3.0	9.5	10.8	-3.0	3.3	3.0
Eye problems/disorders: None of the above	3.3	3.8	5.0	2.2	-1.7	-1.9
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.2	-0.4	0.5
Emphysema/chronic bronchitis	0.4	0.5	0.6	0.7	-0.7	-0.7
Medication for pain relief, constipation, heartburn	0.6	1.1	3.1	0.3	1.8	0.0
Neck or shoulder pain in last month	1.3	1.9	2.6	1.6	-0.8	-1.6
Medication: Blood pressure	3.0	5.4	9.2	-2.4	1.0	3.0
Angina (self-reported)	2.6	3.4	6.9	1.1	-2.6	-1.5
Migraine (self-reported)	1.5	1.8	2.3	1.3	-1.5	-1.2
Medication: Ibuprofen	0.4	0.5	1.1	-0.7	-1.0	-0.1
Medication: Allopurinol	5.2	6.9	9.8	-3.1	1.1	3.1
Medication: Omeprazole	1.7	2.0	3.4	1.8	-0.8	-1.4
Medication: Seretide 50 evohaler	0.7	0.8	1.3	0.9	-0.6	-1.2
Mean time to correctly identify matches	0.3	0.5	1.1	1.0	0.6	-0.5
Heart disease (mother)	0.1	0.1	0.2	-0.2	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.8	-1.1	0.9	1.4
Whole body fat mass	0.7	3.1	6.0	-2.4	-0.7	1.7
Leg fat mass (right)	1.4	5.6	10.7	-3.3	-0.6	2.4
Arm predicted mass (right)	0.2	1.0	2.4	-0.6	-1.5	0.5
Pulse rate, automated reading	2.5	8.0	10.6	1.8	-3.2	-3.3
Alcohol intake frequency.	0.5	1.2	1.7	1.0	-0.9	-1.3
Comparative height size at age 10	1.6	9.0	9.5	3.1	-3.0	-3.0
Number of full sisters	5.4	6.6	7.8	2.8	-2.3	-2.6
Suffer from ‘nerves’	0.9	1.5	3.0	1.1	-0.5	-1.7
Overall health rating	0.8	1.8	2.9	1.2	-1.7	-1.0
Chest pain or discomfort	1.6	2.3	3.8	0.9	-1.9	-1.5
Had major operations	0.5	0.6	1.5	0.6	1.2	-0.0
Age at last live birth	0.1	0.2	0.6	-0.8	-0.1	-0.0
Family relationship satisfaction	0.1	0.1	0.2	0.5	-0.1	-0.2
Leg pain on walking	0.6	0.8	1.4	0.8	-1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.1	-0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	-0.4	-0.4	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.5	0.0	1.6	0.3
Medication: Aspirin	0.5	0.7	1.6	-0.3	-1.3	-0.6
Supplements: Vitamin C	1.0	1.2	1.9	1.3	0.0	-1.4
Knee pain experienced in last month	1.3	2.0	2.9	1.7	-1.0	-1.5
Hypertension (Self-reported)	1.3	3.6	4.9	-2.2	1.6	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.1	-0.5	0.1
Illnesses of father: Heart disease	1.5	2.1	3.6	1.7	0.0	-1.9
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.6	0.2	0.6
Smoking status: Previous	2.2	3.3	5.3	-2.3	0.9	2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	5.5	2.3	-2.0	-2.4
Whole body fat-free mass	0.1	0.8	2.4	0.2	-1.6	-0.1
Leg fat-free mass (right)	0.2	1.3	3.3	0.7	-1.8	-0.2
Arm fat percentage (left)	1.3	5.4	9.8	-3.1	-0.1	2.5
Average weekly red wine intake	4.2	6.1	11.8	-3.4	0.5	2.5
Handedness (chirality/laterality): Left-handed	6.4	7.7	8.4	-2.8	2.9	2.7
Mood swings	1.1	2.1	3.7	1.2	-1.9	-1.1
Loneliness, isolation	3.0	4.1	6.7	1.4	-2.6	-1.9
Long-standing illness, disability or infirmity	2.2	3.4	6.2	1.4	-2.5	-1.4
Ever had bowel cancer screening	1.3	1.5	2.4	-1.5	0.4	1.4
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.3	-0.7	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.8	0.9	-0.9	-0.2
Friendships satisfaction	0.2	0.3	0.6	0.3	0.8	-0.4
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.4	0.2	0.9
Commuting to job workplace: Walk	2.0	2.1	2.3	1.5	-1.4	-1.5
Eye problems/disorders: Cataract	4.5	5.2	7.1	-2.1	2.7	2.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.4	-0.8	-0.0
Medication for cholesterol	2.0	3.0	6.2	1.4	-2.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	0.4	1.4	-0.2
Back pain experienced in last month	1.3	1.9	4.3	0.3	-2.1	-1.1
Mineral and other dietary supplements	0.0	0.0	0.1	-0.1	-0.3	0.1
Breast cancer (self-reported)	0.4	0.5	0.7	-0.4	0.8	0.8
Asthma (self-reported)	0.5	1.0	2.9	0.4	-1.7	0.1
Osteoporosis (self-reported)	0.1	0.2	0.5	0.1	-0.7	0.1
Osteoarthritis (self-reported)	1.9	2.5	2.9	-1.6	1.7	1.4
Medication: Aspirin	0.3	0.4	0.8	-0.5	-0.9	-0.4
Medication: Gliclazide	1.0	1.1	2.7	0.2	-1.6	-0.7
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	-0.9	1.1	0.5
Smoking status: Current	0.1	0.1	0.3	-0.0	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.7	1.1	-0.0	-1.3
Whole body water mass	0.1	0.7	2.1	0.0	-1.4	0.1
Leg predicted mass (right)	0.2	1.2	3.2	0.7	-1.8	-0.2
Arm fat mass (left)	1.0	4.0	7.2	-2.7	-0.6	2.1
Number of self-reported non-cancer illnesses	0.1	0.3	0.7	-0.2	-0.8	0.2
Average weekly champagne plus white wine intake	2.5	3.4	4.2	-2.1	1.9	1.6
Miserableness	0.2	0.3	0.9	-0.3	-0.9	0.0
Guilty feelings	0.1	0.2	0.3	-0.6	0.3	-0.3
Wears glasses or contact lenses	0.4	0.5	1.4	-1.2	0.3	0.3
Ever taken oral contraceptive pill	0.6	0.7	1.0	-1.0	0.4	0.9
Hearing aid user	0.1	0.1	0.2	0.4	-0.2	-0.4
Mother’s age at death	0.3	0.4	0.6	-0.8	0.6	0.5
Financial situation satisfaction	0.2	0.3	0.8	0.1	-0.9	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.0	-0.8	-0.6
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.1	-0.7	-0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	0.5	-0.8	-0.2
Medication: Blood pressure	1.6	3.1	3.1	-1.8	1.7	1.7
Pain type(s) experienced in last month: Hip pain	2.7	3.4	6.0	2.4	-0.5	-2.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.4	1.2	0.8
High cholesterol (Self-reported)	0.4	0.8	1.2	-0.7	1.1	0.8
Medication: Bendroflumethiazide	0.9	1.4	2.2	-0.9	1.5	1.0
Medication: Paracetamol	0.3	0.5	1.5	0.1	-1.2	-0.3
Medication: Lisinopril	4.1	5.3	5.7	-2.4	2.3	2.2
Medication: Atorvastatin	0.1	0.1	0.1	-0.4	0.1	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.1	0.3	-0.4
Alcohol drinker status: Never	0.1	0.2	0.3	-0.3	-0.5	0.3
Ever smoked	1.4	2.5	4.2	-1.7	0.4	2.1
Basal metabolic rate	0.2	1.1	3.3	0.0	-1.8	-0.1
Leg fat percentage (left)	2.6	9.4	19.0	-4.4	0.4	3.0
Arm fat-free mass (left)	0.2	1.0	1.9	-0.8	-1.4	0.6
Number of operations (self-reported)	0.2	0.2	0.4	0.5	0.7	-0.2
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1	0.0
Irritability	0.4	0.7	1.2	1.0	-0.0	-1.1
Risk taking	0.2	0.4	0.8	0.9	0.3	-0.4
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.3	1.5	-0.3	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.2	-1.1	-0.2
Age started oral contraceptive pill	2.3	2.8	3.7	-1.9	1.4	1.7
Diastolic blood pressure, automated reading	0.8	2.5	3.8	-1.9	1.7	0.8
Ever depressed for a whole week	0.0	0.0	0.0	0.1	0.2	0.1
Unable to work because of sickness or disability	2.1	2.7	4.1	2.0	-1.1	-1.7
Commuting to job workplace: Cycle	0.2	0.3	0.8	-0.1	-0.9	0.4
Myopia	1.7	2.5	5.4	0.2	-2.3	-1.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	0.9	-0.2	-0.6
Cholesterol lowering medication	3.5	5.1	6.9	-2.2	2.6	1.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.7	1.6	-0.9	-1.1
Pain experienced in last month	3.5	5.9	7.5	-2.0	2.7	2.5
Supplements: Calcium	0.9	1.0	1.4	-0.9	1.2	0.9
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-1.0	-0.2	-0.0
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.7	0.5	-1.9	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.3	-1.1	-0.1	0.8
Heart disease (siblings)	0.5	0.6	1.3	-1.1	0.1	0.7
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.0	-0.3	-0.5
Pack years of smoking	0.5	0.8	1.3	-1.1	0.3	0.9
Impedance of whole body	2.3	11.9	18.0	4.0	-1.2	-4.2
Leg fat mass (left)	1.5	5.9	11.3	-3.4	-0.4	2.5
Arm predicted mass (left)	0.2	1.1	2.4	-0.7	-1.5	0.5