Hub : Genes

FASN

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0423 0.0176 0.00076 0.048 NA 0.033 NA 0.031 1.6e-05 NA 3.1e-04 NA 5.1e-04
2 GTEx Whole Blood 0.0600 0.0280 0.00190 -0.001 NA 0.010 NA 0.003 3.8e-01 NA 4.0e-02 NA 1.6e-01
3 YFS Blood 0.0842 0.0186 0.00000 0.086 0.123 0.130 NA 0.132 1.3e-26 5e-38 2.3e-40 NA 4.8e-41

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.8 1.6 0.9 1.3 -0.0
Bipolar Disorder or Schizophrenia 1.1 2.6 3.6 1.9 1.8 -1.0
Depressed Affect (Nagel 2018) 0.4 0.8 2.0 0.1 -1.4 -0.5
Depression (Nagel 2018) 0.7 1.0 1.7 0.6 -1.3 -1.0
Intelligence (Savage-Jansen 2018) 0.6 1.9 2.5 -1.6 1.2 1.3
Neuroticism (Nagel 2018) 0.7 1.5 2.8 1.0 -1.0 -1.7
Schizophrenia (2018) 1.0 2.0 3.0 1.7 1.2 -1.2
Schizophrenia vs Biploar Disorder 1.0 1.3 2.2 1.5 -0.2 -1.3
Worry (Nagel 2018) 0.8 1.7 3.1 1.4 0.2 -1.8
Alzheimer’s Disease (in mother) 3.2 3.8 5.5 -1.9 1.4 2.3
Alzheimer’s Disease (in father) 0.4 0.5 1.0 -0.5 1.0 0.4
Alzheimer’s Disease (including proxy) 2.1 3.1 3.8 -1.5 1.8 1.9
Crohns Disease (2017) 0.1 0.2 0.2 0.3 0.5 -0.5
Irritable Bowel Disease (IBD) 0.1 0.4 0.7 0.5 -0.3 -0.8
Ulcerative Colitis (UC) 0.2 0.5 0.7 0.3 -0.8 -0.8
Major Depression (MDD) 2.7 3.2 5.1 2.3 0.0 -2.1
Reaction Time 0.8 1.5 2.7 1.6 -0.2 -1.3
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.9 -0.5 -0.9 0.0
Breast Cancer 0.7 1.8 4.2 0.7 -2.1 -0.8
Ovarian Cancer 0.3 0.4 1.0 -0.4 1.0 0.1
Prostate Cancer 3.5 4.9 7.7 -0.8 2.8 2.5
Age at First Birth 1.2 1.8 2.2 -1.5 1.5 1.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 8.2 11.2 13.9 -2.9 3.7 3.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.2
Crohns Disease (2012) 0.3 0.4 0.8 0.6 0.1 -0.9
Mean Putamen Volume 1.0 1.1 3.2 0.1 -1.8 -0.4
Fasting Glucose 0.1 0.1 0.2 -0.0 -0.4 -0.4
HbA1C 2.0 2.2 4.5 -0.5 2.1 1.4
HDL Cholesterol 1.2 2.0 3.0 -1.7 0.9 1.5
LDL Cholesterol 1.7 2.6 3.7 -1.1 1.7 1.9
Lupus 0.1 0.1 0.2 0.1 -0.2 -0.5
Neuroticism (2016) 2.1 3.1 5.1 0.9 -2.3 -1.8
Primary Biliary Cirrhosis 1.8 2.6 3.0 1.7 -1.6 -1.5
Rheumatoid Arthritis 1.3 1.8 3.7 0.6 -1.9 -1.2
Schizophrenia (2014) 1.4 3.1 5.3 2.3 1.3 -1.5
Triglycerides 1.9 3.1 4.2 -1.4 1.8 2.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.0 0.0 0.0 1.4
Ulcerative Colitis 0.5 0.7 1.1 0.5 -0.8 -1.0
Blood Eosinophil Count 1.3 10.1 12.0 -3.4 2.6 3.5
Blood Platelet Count 0.1 1.5 4.1 0.5 -2.0 0.5
Blood Red Count 0.1 0.9 1.2 -1.1 -1.0 -0.7
Blood White Count 0.1 0.6 1.1 0.9 -1.1 -0.1
Heel T-Score 0.3 2.3 4.0 -1.7 2.0 -0.1
BMI 3.0 17.3 26.0 -5.1 1.0 5.0
Height 2.3 43.5 55.7 6.5 -5.7 -7.5
Waist Hip Ratio (WHR) 0.7 3.0 6.8 -2.6 0.5 1.4
Systolic Blood Pressure 0.1 0.3 0.7 0.4 0.8 -0.1
Smoking Status 1.3 3.1 4.9 -2.0 0.7 2.2
Allergy or Eczema 1.8 4.9 9.4 -3.1 -0.1 2.3
Cardiovascular Disease 0.1 0.4 0.5 -0.7 0.6 0.7
Hypothyroidism (self reported) 0.1 0.3 0.6 -0.4 0.4 0.8
Respiratory disease 0.2 0.4 0.6 0.8 -0.8 -0.4
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 -0.2 -0.3 -0.2
Lung FEV1/FVC ratio 0.2 0.8 1.3 -1.2 -0.1 1.0
Lung FVC 1.3 6.7 10.0 2.6 -1.7 -3.2
Neuroticism 0.0 0.0 0.1 -0.1 -0.2 -0.2
Chronotype (morning person) 0.5 1.1 2.0 0.9 -0.8 -1.4
Hair Pigment 0.1 1.7 3.6 1.2 1.9 0.1
Tanning 0.0 0.1 0.2 0.2 -0.4 0.4
Hand grip strength (left) 0.6 1.5 1.9 -1.3 1.4 1.0
Number of treatments/medications taken 0.2 0.3 0.6 -0.1 -0.8 0.6
Average weekly spirits intake 0.1 0.1 0.1 -0.3 0.4 0.2
Sensitivity / hurt feelings 1.3 2.3 3.5 1.5 -1.1 -1.9
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.0 1.0 -1.1 -1.4
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.4 -0.5 -0.4
Relative age of first facial hair 0.3 0.6 1.0 0.7 1.0 0.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 0.3 0.6 -0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.7 -0.8 0.4 -0.0
Ever had hysterectomy (womb removed) 0.2 0.3 0.5 -0.7 -0.1 0.6
Systolic blood pressure, automated reading 0.8 2.3 3.2 -1.4 1.8 1.3
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.1 0.2 0.1
Angina 1.6 2.1 4.8 0.7 -2.2 -1.1
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.1 0.3 -0.5
Vitamin and mineral supplements 2.7 3.7 5.1 -2.1 1.3 2.3
Supplements: Zinc 0.7 0.7 1.2 0.3 -1.0 -1.1
Medication: Co-codamol 1.3 1.5 2.3 -1.1 -1.5 1.0
Medication: Metformin 0.2 0.3 0.4 -0.3 -0.6 0.6
Diabetes (father) 0.3 0.4 0.6 0.7 -0.1 -0.7
Diabetes (mother) 0.0 0.0 0.0 -0.1 0.0 0.1
Severe depression (siblings) 1.5 1.7 3.2 1.4 -0.1 -1.8
Pack years adult smoking proportion 0.4 0.6 1.0 -1.0 0.0 0.9
Impedance of leg (right) 0.9 4.4 8.7 2.1 -0.6 -2.9
Leg fat-free mass (left) 0.3 1.4 4.0 0.5 -2.0 -0.2
Trunk fat percentage 0.4 1.8 3.8 -2.0 -0.4 1.2
Hand grip strength (right) 0.2 0.6 1.5 -0.3 1.2 0.5
Townsend deprivation index at recruitment 1.0 1.5 1.6 1.3 -1.3 -1.1
Current tobacco smoking 0.1 0.2 0.3 0.6 -0.6 0.0
Average weekly fortified wine intake 0.8 0.9 1.7 -1.3 0.3 1.0
Maternal smoking around birth 1.1 1.5 3.9 -0.2 2.0 0.8
Fed-up feelings 0.1 0.2 0.5 -0.3 -0.7 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.0 0.7 -1.0 -1.0
Relative age voice broke 0.1 0.1 0.2 -0.0 0.5 0.2
Taking other prescription medications 0.7 1.0 1.3 -0.6 -1.2 1.1
Age when periods started (menarche) 1.5 3.5 5.4 2.3 -1.2 -1.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.7 0.2 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 0.9 -0.9 1.0 0.7
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 3.2 1.8 -0.7 -1.8
Qualifications: CSEs or equivalent 0.3 0.4 0.9 -0.9 0.5 0.1
Serious illness, injury or assault to yourself 1.4 1.7 2.2 1.2 -1.5 -1.2
High blood pressure 0.7 2.0 2.6 -1.6 1.3 1.3
Hayfever, allergic rhinitis or eczema 1.2 2.5 5.0 -2.2 -0.3 1.6
Multivitamins +/- minerals 0.6 0.8 1.1 0.8 -0.8 -1.1
Stomach or abdominal pain in last month 0.9 1.2 3.4 0.2 1.8 -0.3
Supplements: Glucosamine 0.2 0.3 0.5 0.5 -0.1 -0.7
Diverticular disease/diverticulitis (self-reported) 2.5 2.9 5.5 -2.3 0.8 1.6
Medication: Atenolol 0.3 0.3 0.8 -0.4 0.2 0.9
Medication: Levothyroxine sodium 1.8 3.1 3.7 -1.9 1.8 1.5
Sitting height 4.8 33.8 38.8 5.9 -6.2 -5.2
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.3 -0.0 0.3
High blood pressure (mother) 0.7 0.9 1.7 1.1 0.1 -1.3
Body mass index (BMI) 2.6 11.1 19.6 -4.4 0.6 3.7
Impedance of leg (left) 0.8 3.8 7.5 2.0 -0.2 -2.7
Leg predicted mass (left) 0.3 1.6 4.3 0.6 -2.1 -0.3
Trunk fat mass 0.4 1.8 3.3 -1.8 -0.9 1.0
Waist circumference 2.8 10.2 19.5 -4.4 -0.3 3.3
Number of incorrect matches in round 0.6 1.0 1.4 1.2 0.7 -1.0
Past tobacco smoking 2.9 5.2 7.8 2.7 -0.8 -2.8
Alcohol usually taken with meals 1.3 2.2 5.2 -2.3 -0.3 1.1
Nervous feelings 4.0 7.5 11.1 3.3 -0.8 -3.3
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 2.8 1.7 -1.0 -1.7
Hearing difficulty/problems with background noise 0.4 0.6 1.0 1.0 -0.4 -0.7
Hair/balding pattern: Pattern 2 0.3 0.4 0.5 0.6 -0.7 -0.5
Had menopause 1.5 1.8 4.0 -1.1 2.0 0.6
Had other major operations 0.4 0.5 1.6 0.1 1.3 0.1
Forced vital capacity (FVC) 4.4 17.0 21.2 4.0 -3.7 -4.6
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.0 -0.8 1.0 0.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 0.4 0.5 0.3
Qualifications: None of the above 0.1 0.2 0.3 0.4 -0.6 -0.4
Financial difficulties in last 2 years 0.2 0.3 0.7 -0.4 -0.9 0.0
Mouth/teeth dental problems 1.4 2.2 5.9 -0.3 2.4 0.8
Heart attack 1.4 1.8 4.6 0.6 -2.1 -0.6
Allergy 0.7 1.6 2.5 1.4 1.6 -0.7
Pain all over the body in last month 0.3 0.4 0.7 -0.3 0.8 0.6
Diabetes (self-reported) 0.0 0.0 0.1 -0.3 -0.2 -0.0
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.4 -0.8 -1.5 0.5
Medication: Ramipril 1.0 1.3 2.1 -1.4 0.2 1.5
Medication: Simvastatin 1.3 2.0 2.9 -1.4 1.0 1.7
Fluid intelligence score 0.2 0.3 0.8 -0.3 -0.9 -0.2
Illnesses of siblings 0.1 0.1 0.3 0.5 -0.3 0.3
Neuroticism score 0.3 0.6 1.0 0.4 -0.9 -1.0
Weight 0.4 2.0 2.9 -1.7 -1.4 1.0
Impedance of arm (right) 2.4 11.1 16.4 4.0 -1.0 -4.0
Arm fat percentage (right) 1.4 5.6 10.6 -3.3 -0.1 2.5
Trunk fat-free mass 0.1 0.8 2.2 0.3 -1.5 -0.3
Hip circumference 0.5 2.1 5.0 -0.9 -2.2 0.6
Time employed in main current job 0.7 0.8 1.3 0.1 -1.1 -1.1
Alcohol intake versus 10 years previously 0.3 0.4 0.7 -0.8 -0.2 0.8
Father’s age at death 0.6 0.8 1.4 1.2 0.6 -0.8
Worrier / anxious feelings 0.1 0.2 0.4 -0.2 0.6 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 3.5 1.9 -1.3 -1.9
Falls in the last year 0.7 1.0 1.4 1.2 -1.0 -0.7
Hair/balding pattern: Pattern 3 0.7 1.0 2.6 -1.6 -0.2 0.6
Number of live births 2.2 3.1 4.3 2.1 -0.9 -2.1
Forced expiratory volume in 1-second (FEV1) 4.0 13.4 14.7 3.4 -3.7 -3.8
Pulse rate 0.5 0.9 1.4 0.9 -0.7 -1.2
Happiness 0.5 0.6 1.7 -0.3 1.3 0.4
Noisy workplace 0.3 0.4 0.8 0.6 -0.3 -0.9
Qualifications: A levels/AS levels or equivalent 0.7 1.7 3.0 -1.7 0.3 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.1 -0.4 0.0
Mouth/teeth dental problems: Dentures 0.7 1.2 2.9 0.4 -1.7 -0.7
Asthma 0.6 1.1 3.0 0.5 -1.7 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.5 0.1 -1.2 -0.6
Medication: Cholesterol lowering 0.3 0.5 0.8 -0.5 -0.9 0.6
Depression (self-reported) 1.6 1.9 3.0 1.7 -0.2 -1.7
Medication: Lansoprazole 0.7 0.8 1.1 1.0 -1.0 -0.6
Prospective memory result 0.3 0.4 0.7 0.6 -0.5 -0.8
Lung cancer (father) 1.8 2.1 4.4 -2.1 0.3 1.4
Illnesses of mother 0.3 0.4 0.5 0.7 -0.7 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 3.8 12.2 14.8 3.3 -3.3 -3.9
Pulse wave Arterial Stiffness index 0.5 0.6 0.9 -0.8 0.4 0.9
Impedance of arm (left) 2.9 13.6 20.8 4.6 -1.1 -4.3
Arm fat mass (right) 1.0 4.2 8.0 -2.8 -0.5 2.1
Trunk predicted mass 0.1 0.7 2.1 0.2 -1.5 -0.2
Standing height 2.9 28.4 34.3 5.9 -4.2 -5.7
Length of working week for main job 1.1 1.2 1.8 -1.0 1.0 1.3
Exposure to tobacco smoke at home 0.3 0.4 1.1 0.0 -1.1 -0.2
Breastfed as a baby 0.2 0.3 0.9 -0.1 0.9 -0.1
Tense / ‘highly strung’ 0.3 0.6 1.0 -0.8 1.0 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.2 -1.1 0.6 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 -0.5 -1.0 -0.4
Birth weight of first child 4.2 7.6 11.9 1.7 -3.4 -2.8
Peak expiratory flow (PEF) 0.5 1.2 1.9 1.4 -0.8 -1.1
Pulse wave reflection index 1.9 2.4 3.2 -1.8 0.9 1.8
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.5 -0.7 0.7 0.5
Loud music exposure frequency 2.1 2.3 2.8 1.6 -1.2 -1.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 0.2 -0.6 -0.7
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.2 0.4 -1.5 -1.3
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.9 -0.3 0.6
Medication: Paracetamol 0.1 0.2 0.4 0.1 -0.7 -0.1
Headache pain in last month 0.1 0.1 0.2 0.4 -0.3 -0.1
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.1 1.0 -0.6 -1.4
Glaucoma (self-reported) 0.3 0.3 0.7 0.4 -0.8 -0.2
Gout (self-reported) 3.8 5.2 6.9 -2.6 1.4 2.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 0.7 -0.8 0.9 0.7
Medication: Amlodipine 0.1 0.2 0.4 0.6 -0.1 -0.5
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 -0.7 -0.5 0.3
Birth weight 1.0 2.1 3.1 1.3 -1.8 -1.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.9 0.3 0.3 -0.9
High blood pressure (siblings) 0.2 0.3 0.5 -0.0 0.7 -0.6
Forced vital capacity (FVC), Best measure 5.1 18.5 23.4 4.2 -3.8 -4.8
Body fat percentage 1.2 4.8 9.8 -3.1 -0.0 2.2
Leg fat percentage (right) 2.4 8.8 18.4 -4.3 0.1 2.9
Arm fat-free mass (right) 0.2 0.9 2.3 -0.4 -1.5 0.3
Exposure to tobacco smoke outside home 0.1 0.2 0.4 0.3 -0.6 0.0
Comparative body size at age 10 1.3 3.7 6.7 -2.6 0.3 2.0
Number of full brothers 2.3 2.9 3.6 1.7 -1.4 -1.9
Worry too long after embarrassment 1.3 2.3 3.4 1.3 -1.3 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.6 0.8 0.5 -0.7
Wheeze or whistling in the chest in last year 0.3 0.5 0.7 0.5 -0.9 -0.7
Number of children fathered 0.3 0.4 0.6 -0.6 -0.8 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 -0.1 -0.1 -0.1
Age at first live birth 0.6 1.0 1.6 -1.3 0.1 1.2
Pulse wave peak to peak time 1.3 1.5 2.1 1.4 -0.7 -1.5
Health satisfaction 0.4 0.5 0.9 1.0 -0.8 -0.1
Shortness of breath walking on level ground 4.4 5.3 5.9 2.4 -2.0 -2.4
Qualifications: College or University degree 3.0 9.5 10.8 -3.0 3.3 3.0
Eye problems/disorders: None of the above 3.3 3.8 5.0 2.2 -1.7 -1.9
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.3 -0.2 -0.4 0.5
Emphysema/chronic bronchitis 0.4 0.5 0.6 0.7 -0.7 -0.7
Medication for pain relief, constipation, heartburn 0.6 1.1 3.1 0.3 1.8 0.0
Neck or shoulder pain in last month 1.3 1.9 2.6 1.6 -0.8 -1.6
Medication: Blood pressure 3.0 5.4 9.2 -2.4 1.0 3.0
Angina (self-reported) 2.6 3.4 6.9 1.1 -2.6 -1.5
Migraine (self-reported) 1.5 1.8 2.3 1.3 -1.5 -1.2
Medication: Ibuprofen 0.4 0.5 1.1 -0.7 -1.0 -0.1
Medication: Allopurinol 5.2 6.9 9.8 -3.1 1.1 3.1
Medication: Omeprazole 1.7 2.0 3.4 1.8 -0.8 -1.4
Medication: Seretide 50 evohaler 0.7 0.8 1.3 0.9 -0.6 -1.2
Mean time to correctly identify matches 0.3 0.5 1.1 1.0 0.6 -0.5
Heart disease (mother) 0.1 0.1 0.2 -0.2 0.1 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.8 -1.1 0.9 1.4
Whole body fat mass 0.7 3.1 6.0 -2.4 -0.7 1.7
Leg fat mass (right) 1.4 5.6 10.7 -3.3 -0.6 2.4
Arm predicted mass (right) 0.2 1.0 2.4 -0.6 -1.5 0.5
Pulse rate, automated reading 2.5 8.0 10.6 1.8 -3.2 -3.3
Alcohol intake frequency. 0.5 1.2 1.7 1.0 -0.9 -1.3
Comparative height size at age 10 1.6 9.0 9.5 3.1 -3.0 -3.0
Number of full sisters 5.4 6.6 7.8 2.8 -2.3 -2.6
Suffer from ‘nerves’ 0.9 1.5 3.0 1.1 -0.5 -1.7
Overall health rating 0.8 1.8 2.9 1.2 -1.7 -1.0
Chest pain or discomfort 1.6 2.3 3.8 0.9 -1.9 -1.5
Had major operations 0.5 0.6 1.5 0.6 1.2 -0.0
Age at last live birth 0.1 0.2 0.6 -0.8 -0.1 -0.0
Family relationship satisfaction 0.1 0.1 0.2 0.5 -0.1 -0.2
Leg pain on walking 0.6 0.8 1.4 0.8 -1.2 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 -0.1 -0.4 -0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.2 -0.4 -0.4 0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.5 0.0 1.6 0.3
Medication: Aspirin 0.5 0.7 1.6 -0.3 -1.3 -0.6
Supplements: Vitamin C 1.0 1.2 1.9 1.3 0.0 -1.4
Knee pain experienced in last month 1.3 2.0 2.9 1.7 -1.0 -1.5
Hypertension (Self-reported) 1.3 3.6 4.9 -2.2 1.6 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 0.1 -0.5 0.1
Illnesses of father: Heart disease 1.5 2.1 3.6 1.7 0.0 -1.9
Illnesses of siblings: Diabetes 0.2 0.2 0.3 -0.6 0.2 0.6
Smoking status: Previous 2.2 3.3 5.3 -2.3 0.9 2.0
Forced expiratory volume in 1-second (FEV1), predicted 2.4 4.9 5.5 2.3 -2.0 -2.4
Whole body fat-free mass 0.1 0.8 2.4 0.2 -1.6 -0.1
Leg fat-free mass (right) 0.2 1.3 3.3 0.7 -1.8 -0.2
Arm fat percentage (left) 1.3 5.4 9.8 -3.1 -0.1 2.5
Average weekly red wine intake 4.2 6.1 11.8 -3.4 0.5 2.5
Handedness (chirality/laterality): Left-handed 6.4 7.7 8.4 -2.8 2.9 2.7
Mood swings 1.1 2.1 3.7 1.2 -1.9 -1.1
Loneliness, isolation 3.0 4.1 6.7 1.4 -2.6 -1.9
Long-standing illness, disability or infirmity 2.2 3.4 6.2 1.4 -2.5 -1.4
Ever had bowel cancer screening 1.3 1.5 2.4 -1.5 0.4 1.4
Diabetes diagnosed by doctor 0.1 0.2 0.5 -0.3 -0.7 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.8 0.9 -0.9 -0.2
Friendships satisfaction 0.2 0.3 0.6 0.3 0.8 -0.4
Qualifications: nursing, teaching 0.2 0.3 0.8 -0.4 0.2 0.9
Commuting to job workplace: Walk 2.0 2.1 2.3 1.5 -1.4 -1.5
Eye problems/disorders: Cataract 4.5 5.2 7.1 -2.1 2.7 2.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.7 0.4 -0.8 -0.0
Medication for cholesterol 2.0 3.0 6.2 1.4 -2.5 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.0 0.4 1.4 -0.2
Back pain experienced in last month 1.3 1.9 4.3 0.3 -2.1 -1.1
Mineral and other dietary supplements 0.0 0.0 0.1 -0.1 -0.3 0.1
Breast cancer (self-reported) 0.4 0.5 0.7 -0.4 0.8 0.8
Asthma (self-reported) 0.5 1.0 2.9 0.4 -1.7 0.1
Osteoporosis (self-reported) 0.1 0.2 0.5 0.1 -0.7 0.1
Osteoarthritis (self-reported) 1.9 2.5 2.9 -1.6 1.7 1.4
Medication: Aspirin 0.3 0.4 0.8 -0.5 -0.9 -0.4
Medication: Gliclazide 1.0 1.1 2.7 0.2 -1.6 -0.7
Illnesses of father: None of the above (group 1) 0.6 0.7 1.2 -0.9 1.1 0.5
Smoking status: Current 0.1 0.1 0.3 -0.0 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.7 1.1 -0.0 -1.3
Whole body water mass 0.1 0.7 2.1 0.0 -1.4 0.1
Leg predicted mass (right) 0.2 1.2 3.2 0.7 -1.8 -0.2
Arm fat mass (left) 1.0 4.0 7.2 -2.7 -0.6 2.1
Number of self-reported non-cancer illnesses 0.1 0.3 0.7 -0.2 -0.8 0.2
Average weekly champagne plus white wine intake 2.5 3.4 4.2 -2.1 1.9 1.6
Miserableness 0.2 0.3 0.9 -0.3 -0.9 0.0
Guilty feelings 0.1 0.2 0.3 -0.6 0.3 -0.3
Wears glasses or contact lenses 0.4 0.5 1.4 -1.2 0.3 0.3
Ever taken oral contraceptive pill 0.6 0.7 1.0 -1.0 0.4 0.9
Hearing aid user 0.1 0.1 0.2 0.4 -0.2 -0.4
Mother’s age at death 0.3 0.4 0.6 -0.8 0.6 0.5
Financial situation satisfaction 0.2 0.3 0.8 0.1 -0.9 0.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 0.0 -0.8 -0.6
Commuting to job workplace: Public transport 0.1 0.2 0.5 0.1 -0.7 -0.0
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 0.5 -0.8 -0.2
Medication: Blood pressure 1.6 3.1 3.1 -1.8 1.7 1.7
Pain type(s) experienced in last month: Hip pain 2.7 3.4 6.0 2.4 -0.5 -2.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.5 -0.4 1.2 0.8
High cholesterol (Self-reported) 0.4 0.8 1.2 -0.7 1.1 0.8
Medication: Bendroflumethiazide 0.9 1.4 2.2 -0.9 1.5 1.0
Medication: Paracetamol 0.3 0.5 1.5 0.1 -1.2 -0.3
Medication: Lisinopril 4.1 5.3 5.7 -2.4 2.3 2.2
Medication: Atorvastatin 0.1 0.1 0.1 -0.4 0.1 0.3
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.1 0.3 -0.4
Alcohol drinker status: Never 0.1 0.2 0.3 -0.3 -0.5 0.3
Ever smoked 1.4 2.5 4.2 -1.7 0.4 2.1
Basal metabolic rate 0.2 1.1 3.3 0.0 -1.8 -0.1
Leg fat percentage (left) 2.6 9.4 19.0 -4.4 0.4 3.0
Arm fat-free mass (left) 0.2 1.0 1.9 -0.8 -1.4 0.6
Number of operations (self-reported) 0.2 0.2 0.4 0.5 0.7 -0.2
Average weekly beer plus cider intake 0.0 0.0 0.0 0.1 -0.1 0.0
Irritability 0.4 0.7 1.2 1.0 -0.0 -1.1
Risk taking 0.2 0.4 0.8 0.9 0.3 -0.4
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.3 1.5 -0.3 -1.1
Fractured/broken bones in last 5 years 0.4 0.5 1.3 0.2 -1.1 -0.2
Age started oral contraceptive pill 2.3 2.8 3.7 -1.9 1.4 1.7
Diastolic blood pressure, automated reading 0.8 2.5 3.8 -1.9 1.7 0.8
Ever depressed for a whole week 0.0 0.0 0.0 0.1 0.2 0.1
Unable to work because of sickness or disability 2.1 2.7 4.1 2.0 -1.1 -1.7
Commuting to job workplace: Cycle 0.2 0.3 0.8 -0.1 -0.9 0.4
Myopia 1.7 2.5 5.4 0.2 -2.3 -1.4
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.9 0.9 -0.2 -0.6
Cholesterol lowering medication 3.5 5.1 6.9 -2.2 2.6 1.9
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 2.7 1.6 -0.9 -1.1
Pain experienced in last month 3.5 5.9 7.5 -2.0 2.7 2.5
Supplements: Calcium 0.9 1.0 1.4 -0.9 1.2 0.9
Basal cell carcinoma (self-reported) 0.3 0.3 1.0 -1.0 -0.2 -0.0
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.7 0.5 -1.9 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.3 -1.1 -0.1 0.8
Heart disease (siblings) 0.5 0.6 1.3 -1.1 0.1 0.7
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.0 -0.3 -0.5
Pack years of smoking 0.5 0.8 1.3 -1.1 0.3 0.9
Impedance of whole body 2.3 11.9 18.0 4.0 -1.2 -4.2
Leg fat mass (left) 1.5 5.9 11.3 -3.4 -0.4 2.5
Arm predicted mass (left) 0.2 1.1 2.4 -0.7 -1.5 0.5