Best TWAS P=1.38e-15 · Best GWAS P=3.44e-18 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TXLNA | 0.04 | 0.04 | bslmm | 221 | 0.03 | 1.8e-04 | 7.0 | -5.8 | 7.5e-09 | -0.20 | 0.84 | 0.01 | TRUE |
| 2 | GTEx | Artery Aorta | PEF1 | 0.15 | 0.05 | lasso | 5 | 0.04 | 2.2e-03 | -5.0 | 5.8 | 5.5e-09 | 0.10 | 0.51 | 0.02 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | KPNA6 | 0.19 | 0.14 | enet | 18 | 0.10 | 4.9e-04 | 7.0 | 6.9 | 4.3e-12 | 0.36 | 0.22 | 0.05 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | KPNA6 | 0.13 | 0.10 | lasso | 5 | 0.11 | 1.3e-08 | 7.0 | 7.0 | 3.4e-12 | 0.38 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Esophagus Mucosa | MTMR9LP | 0.07 | 0.09 | lasso | 3 | 0.05 | 1.5e-04 | 4.5 | 5.3 | 1.4e-07 | 0.35 | 0.73 | 0.09 | FALSE |
| 6 | GTEx | Nerve Tibial | TXLNA | 0.10 | 0.00 | enet | 5 | 0.00 | 6.8e-01 | -1.9 | -5.6 | 2.4e-08 | -0.32 | 0.04 | 0.04 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | EIF3I | 0.12 | 0.06 | lasso | 1 | 0.03 | 7.2e-03 | 6.9 | -6.9 | 6.5e-12 | -0.38 | 0.09 | 0.04 | FALSE |
| 8 | GTEx | Testis | RP4-622L5.7 | 0.12 | 0.11 | lasso | 5 | 0.08 | 2.3e-04 | 7.0 | 7.0 | 2.5e-12 | 0.38 | 0.35 | 0.13 | FALSE |
| 9 | METSIM | Adipose | KPNA6 | 0.07 | 0.06 | lasso | 10 | 0.06 | 1.8e-09 | 6.9 | 7.1 | 1.2e-12 | 0.40 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | KPNA6 | 0.03 | 0.04 | lasso | 4 | 0.02 | 8.1e-04 | 7.0 | 7.1 | 1.3e-12 | 0.42 | 0.60 | 0.22 | TRUE |
| 11 | YFS | Blood | KPNA6 | 0.03 | 0.03 | bslmm | 236 | 0.04 | 1.1e-11 | 6.7 | 7.0 | 1.7e-12 | 0.40 | 1.00 | 0.00 | TRUE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM39B | 0.04 | 0.03 | blup | 16 | 0.03 | 5.0e-04 | 6.9 | -6.4 | 1.2e-10 | -0.31 | 0.01 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MTMR9L | 0.03 | 0.03 | blup | 28 | 0.01 | 1.6e-02 | 4.7 | 6.0 | 1.6e-09 | 0.39 | 0.03 | 0.60 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KPNA6 | 0.02 | 0.02 | blup | 29 | 0.02 | 1.9e-03 | 6.9 | 6.6 | 3.1e-11 | 0.36 | 0.02 | 0.87 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MTMR9L | 0.04 | 0.04 | blup | 29 | 0.02 | 1.0e-03 | 4.5 | 5.7 | 1.6e-08 | 0.40 | 0.18 | 0.48 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | MTMR9L | 0.03 | 0.00 | blup | 30 | 0.01 | 1.0e-02 | 4.4 | 6.2 | 4.2e-10 | 0.32 | 0.01 | 0.62 | TRUE |
| 17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TMEM39B | 0.05 | 0.04 | enet | 9 | 0.05 | 1.7e-04 | 6.9 | -6.0 | 1.4e-09 | -0.22 | 0.01 | 0.82 | FALSE |
| 18 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | MTMR9L | 0.15 | 0.02 | blup | 29 | 0.09 | 2.8e-03 | 1.6 | 5.3 | 9.7e-08 | 0.35 | 0.01 | 0.37 | FALSE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PTP4A2 | 0.09 | -0.01 | blup | 26 | 0.00 | 4.1e-01 | 6.1 | 8.0 | 1.4e-15 | 0.80 | 0.01 | 0.57 | TRUE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM167B | 0.03 | 0.01 | blup | 26 | 0.02 | 2.4e-03 | 4.7 | -5.4 | 5.9e-08 | -0.37 | 0.02 | 0.71 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | KPNA6 | 0.03 | 0.03 | blup | 28 | 0.03 | 5.3e-04 | 6.7 | 6.9 | 4.6e-12 | 0.34 | 0.02 | 0.89 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | MTMR9L | 0.03 | 0.04 | blup | 28 | 0.03 | 3.3e-04 | 4.4 | 6.3 | 3.4e-10 | 0.38 | 0.02 | 0.93 | TRUE |