TWAS hub - MTMR9L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0142	0.0085	0.00100	0.020	0.014	0.012	NA	0.018	5.4e-05	0.00063	1.1e-03	NA	9.7e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0257	0.0168	0.00280	0.026	0.012	0.004	NA	0.011	6.2e-04	0.01600	9.7e-02	NA	1.8e-02
3	TCGA	Brain Lower Grade Glioma	0.0399	0.0245	0.00093	0.037	0.023	0.015	NA	0.019	4.5e-05	0.00100	7.6e-03	NA	2.7e-03
4	TCGA	Lung Adenocarcinoma	0.0267	0.0165	0.00400	0.004	0.013	-0.001	NA	0.000	9.1e-02	0.01000	5.4e-01	NA	3.2e-01
5	TCGA	Lung Squamous Cell Carcinoma	0.0313	0.0191	0.00076	0.040	0.023	0.038	NA	0.035	2.2e-05	0.00100	3.1e-05	NA	7.2e-05
6	TCGA	Skin Cutaneous Melanoma	0.1500	0.0870	0.00840	0.021	0.085	0.085	NA	0.029	8.7e-02	0.00280	2.8e-03	NA	5.6e-02
7	TCGA	Thyroid Carcinoma	0.0270	0.0160	0.00064	0.036	0.033	0.018	NA	0.033	2.0e-04	0.00033	6.8e-03	NA	3.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Tinnitus: Yes, now most or all of the time	6.3	7.4	9.3	2.8	3.0	2.5	3.0	2.8	2.6	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.1	7.3	10.4	2.4	2.9	2.3	2.9	2.7	3.2	2.3
Illnesses of father: High blood pressure	6.1	7.5	10.7	-2.7	-2.8	-3.3	-2.1	-2.6	-2.3	-3.3
Pulse wave Arterial Stiffness index	5.4	6.3	9.2	2.2	2.7	2.8	1.6	2.1	2.8	3.0
Supplements: Calcium	5.2	5.8	7.7	2.7	2.4	2.7	2.1	2.8	2.0	2.0
Number of live births	5.1	7.3	8.9	2.5	3.0	2.7	2.9	2.3	2.5	3.0
Relative age voice broke	4.5	6.8	8.3	2.6	2.9	2.8	2.5	2.6	2.1	2.6
Bilateral oophorectomy (both ovaries removed)	4.3	4.9	6.9	2.6	2.1	2.4	2.2	2.5	0.9	2.3
Sitting height	4.2	30.1	39.4	4.4	6.0	5.7	6.2	4.0	5.3	6.3
Arm fat-free mass (right)	4.2	21.5	31.2	3.3	5.3	4.7	4.8	2.8	5.6	5.3
Arm predicted mass (right)	4.0	20.5	31.0	3.1	5.2	4.5	4.8	2.7	5.6	5.1
Ever depressed for a whole week	4.0	5.0	8.1	2.0	2.4	1.8	2.5	2.2	2.9	1.7
Pulse wave peak to peak time	3.8	4.5	6.7	-1.9	-2.3	-2.4	-1.2	-1.8	-2.4	-2.6
Number of self-reported non-cancer illnesses	3.8	6.6	8.9	2.8	2.6	2.2	2.6	3.0	2.1	2.5
Qualifications: CSEs or equivalent	3.7	4.9	7.2	-2.2	-2.3	-2.2	-2.3	-2.0	-2.7	-1.7
Trunk fat-free mass	3.6	20.6	28.7	3.2	5.2	4.7	4.9	2.7	5.4	5.0
Trunk predicted mass	3.6	20.4	28.5	3.2	5.2	4.7	4.9	2.7	5.3	5.0
Arm fat-free mass (left)	3.6	18.3	28.3	2.8	4.9	4.2	4.6	2.3	5.3	4.9
Chronic bronchitis/emphysema (father)	3.5	4.1	4.8	-2.1	-2.2	-2.2	-1.8	-2.0	-2.1	-1.8
Lupus	3.4	5.1	9.1	2.2	2.4	3.0	1.6	2.1	2.0	2.2
Comparative height size at age 10	3.4	18.5	25.6	2.9	4.8	4.7	4.7	2.1	5.1	4.8
Suffer from ‘nerves’	3.4	5.3	10.2	-1.5	-2.6	-2.4	-1.9	-1.8	-3.2	-2.2
Whole body fat-free mass	3.4	19.2	26.5	3.1	5.1	4.4	4.7	2.6	5.2	4.9
Arm predicted mass (left)	3.4	17.3	27.0	2.6	4.8	4.0	4.5	2.1	5.2	4.8
Standing height	3.3	32.3	40.7	4.2	6.4	6.2	6.3	3.7	6.1	6.2
Length of working week for main job	3.3	3.6	6.2	-1.9	-1.6	-2.5	-1.7	-1.6	-1.4	-2.4
Number of full brothers	3.3	4.1	5.2	-2.3	-1.8	-2.3	-1.8	-2.2	-2.1	-1.6
Whole body water mass	3.3	18.6	26.5	3.0	5.0	4.3	4.7	2.5	5.2	4.8
Verbal and Numeric Reasoning (VNR)	3.2	7.8	12.4	2.2	3.0	3.1	2.6	2.3	3.5	2.6
Average weekly champagne plus white wine intake	3.2	4.4	8.0	2.1	2.0	2.8	1.4	2.2	2.3	1.6
Basal metabolic rate	3.1	17.0	24.1	2.7	4.8	4.1	4.5	2.3	4.9	4.7
High cholesterol (Self-reported)	3.0	5.3	7.6	2.5	2.2	2.8	1.9	2.5	2.0	2.1
Pain all over the body in last month	2.7	2.9	4.3	-1.6	-1.6	-1.7	-2.1	-1.5	-2.0	-1.3
Depression (Nagel 2018)	2.6	4.0	5.2	1.9	2.3	2.0	2.0	2.0	1.7	2.1
Leg fat-free mass (left)	2.6	14.0	19.4	2.5	4.4	3.6	4.1	2.2	4.3	4.3
Pulse wave reflection index	2.6	3.2	5.7	1.4	2.0	2.1	0.9	1.4	1.8	2.4
Pain experienced in last month	2.6	4.3	5.2	2.0	2.3	2.2	1.9	2.0	2.2	1.9
Rheumatoid Arthritis	2.5	3.4	5.3	1.7	1.8	2.1	2.2	0.0	2.3	1.9
Leg predicted mass (left)	2.5	13.1	18.1	2.4	4.3	3.4	4.0	2.1	4.2	4.2
Leg fat-free mass (right)	2.5	13.6	18.2	2.6	4.3	3.6	4.0	2.2	4.2	4.2
Leg predicted mass (right)	2.5	13.5	18.1	2.5	4.3	3.7	4.0	2.2	4.2	4.2
Illnesses of father: None of the above (group 1)	2.4	2.9	4.7	1.5	1.9	1.9	1.4	1.4	1.6	2.2
Height	2.3	44.5	58.4	4.7	7.6	7.0	7.4	3.9	7.4	7.6
Number of treatments/medications taken	2.3	4.1	6.3	1.9	2.5	1.9	1.8	1.9	2.1	1.9
Breastfed as a baby	2.3	2.9	5.6	1.2	1.8	1.5	1.5	1.4	2.4	1.8
Hearing difficulty/problems: Yes	2.2	3.4	5.5	1.7	1.9	1.2	2.3	1.7	2.3	1.3
Taking other prescription medications	2.2	3.4	5.6	1.4	2.4	1.6	1.7	1.4	2.1	2.0
Myopia	2.2	3.1	5.7	2.4	1.9	1.7	0.9	2.4	1.1	1.6
Intelligence (Savage-Jansen 2018)	2.1	6.5	7.7	2.2	2.7	2.7	2.4	2.4	2.8	2.6
Loud music exposure frequency	2.1	2.2	3.6	1.3	1.9	1.5	0.7	1.5	1.8	1.4
Medication: Co-codamol	2.0	2.3	3.5	0.9	1.7	1.6	1.4	1.0	1.8	1.9
Weight	2.0	10.1	15.9	1.8	3.7	3.0	3.5	1.5	4.0	3.8
Commuting to job workplace: Public transport	2.0	2.4	3.4	1.5	1.7	1.4	1.5	1.8	1.0	1.8
Reaction Time	1.9	3.6	7.7	-2.7	-1.3	-1.9	-1.7	-2.8	-0.6	-1.3
Schizophrenia (2014)	1.9	4.1	9.1	-3.0	-2.0	-2.3	-2.1	0.0	-1.4	-2.0
Fasting Glucose	1.8	2.1	2.9	1.4	1.7	1.5	1.1	1.6	1.0	1.7
Smoking Status	1.8	4.4	6.2	2.2	2.5	2.2	1.3	2.1	1.7	2.4
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.7	0.9	1.4	1.0	1.4	1.0	2.2	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	4.8	2.0	2.0	2.1	2.2	1.9	2.2	1.9
Diabetes (self-reported)	1.8	2.8	4.2	1.6	1.8	1.5	1.4	1.5	2.0	1.8
Medication: Allopurinol	1.8	2.4	5.7	0.9	1.9	1.0	1.7	1.1	2.4	1.3
Mineral and other dietary supplements	1.8	2.4	5.1	-0.6	-2.1	-1.1	-1.6	-0.7	-2.3	-1.6
Eye problems/disorders: Cataract	1.7	1.9	3.8	1.1	1.3	1.1	1.9	1.1	1.7	1.2
Wears glasses or contact lenses	1.7	2.0	3.8	1.2	1.6	1.4	1.2	0.9	1.3	1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	5.0	2.2	1.8	1.9	1.6	2.1	1.7	1.7
Fluid intelligence score	1.6	3.4	6.7	1.1	1.9	1.9	2.0	1.2	2.6	1.9
Number of full sisters	1.6	1.9	2.8	1.6	1.5	1.3	0.8	1.7	0.9	1.6
Qualifications: nursing, teaching	1.6	2.5	3.8	-1.7	-1.7	-1.9	-0.8	-1.8	-0.8	-1.8
Noisy workplace	1.5	1.8	3.0	1.7	1.1	1.5	1.3	1.7	0.9	1.0
Asthma	1.5	2.9	3.4	1.7	1.6	1.6	1.8	1.7	1.7	1.8
Prospective memory result	1.5	1.8	4.6	-0.7	-1.3	-1.6	-1.3	-0.6	-1.2	-2.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	3.6	-1.6	-1.8	-1.3	-1.5	-1.5	-1.9	-1.3
Medication: Blood pressure	1.5	2.7	4.4	1.4	2.1	1.2	1.5	1.3	2.1	1.6
Asthma (self-reported)	1.5	3.0	4.0	1.7	1.7	1.6	2.0	1.6	1.8	1.8
Number of operations (self-reported)	1.5	2.2	5.2	0.9	1.4	1.1	2.3	0.6	1.9	1.5
Medication: Metformin	1.4	1.9	2.2	1.4	1.4	1.3	1.3	1.4	1.5	1.4
Eye problems/disorders: None of the above	1.4	1.7	3.6	-0.8	-1.2	-1.1	-1.9	-0.9	-1.8	-1.0
Medication: Aspirin	1.4	1.9	4.0	1.0	1.9	1.2	0.5	1.1	2.0	1.1
Knee pain experienced in last month	1.4	2.2	3.8	-1.8	-1.5	-1.6	-0.6	-1.9	-0.6	-1.7
Long-standing illness, disability or infirmity	1.4	2.1	2.8	1.4	1.7	1.6	1.4	1.0	1.3	1.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.4	0.5	1.8	0.6	1.5	0.7	1.6	1.7
Had other major operations	1.3	1.6	3.6	1.0	1.1	1.0	1.6	1.0	1.1	1.9
Supplements: Vitamin C	1.3	1.5	3.4	1.2	1.2	1.1	1.0	1.0	1.9	1.1
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	3.7	1.0	1.9	1.0	1.5	1.2	1.6	1.5
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.4	1.2	1.6	1.4	1.5	1.0	2.1	1.6
Multivitamins +/- minerals	1.2	1.6	3.2	0.7	1.6	1.6	0.7	0.9	1.8	0.9
Trunk fat mass	1.2	5.3	9.0	1.0	2.8	1.9	2.5	1.0	3.0	2.9
Allergy	1.2	2.6	5.4	-1.3	-1.7	-1.3	-2.3	-1.4	-1.9	-1.3
Medication: Cholesterol lowering	1.2	1.8	2.8	1.7	1.4	1.5	1.0	1.5	1.2	1.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.6	1.8	1.4	1.4	1.9	1.9	0.6	1.5
Bipolar Disorder or Schizophrenia	1.1	2.8	5.1	-2.3	-1.8	-2.1	-1.6	0.0	-1.1	-1.7
Systolic blood pressure, automated reading	1.1	3.3	4.9	-1.4	-2.0	-2.2	-1.3	-1.5	-2.0	-1.9
Hair/balding pattern: Pattern 2	1.1	1.4	3.1	1.3	0.9	1.0	1.8	1.4	0.6	1.0
Whole body fat mass	1.1	4.5	7.6	0.8	2.6	1.7	2.2	0.8	2.7	2.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.7	0.9	1.1	1.6	0.7	0.9	1.0	1.0
Commuting to job workplace: Walk	1.1	1.2	1.9	-1.0	-1.2	-0.6	-1.1	-1.0	-1.4	-1.3
Medication: Aspirin	1.1	1.5	4.1	0.8	1.8	0.9	0.3	0.8	2.0	1.0
Schizophrenia vs Biploar Disorder	1.0	1.4	3.4	-1.9	-1.0	-1.7	-0.7	0.0	-0.3	-1.3
LDL Cholesterol	1.0	1.5	3.0	-1.6	-1.0	-1.7	-0.6	-1.4	-0.6	-1.2
Relative age of first facial hair	1.0	2.1	3.5	1.9	1.3	1.6	1.4	1.7	0.7	1.3
Diabetes (mother)	1.0	1.3	2.3	0.8	1.2	1.0	0.9	0.9	1.5	1.5
Medication: Levothyroxine sodium	1.0	1.7	2.4	1.3	1.2	1.5	1.5	1.2	0.7	1.6
High blood pressure (mother)	1.0	1.4	3.3	-0.4	-1.5	-1.2	-0.8	-0.6	-1.8	-1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.4	1.5	0.9	0.7	1.6	1.4	0.6	0.7
Birth weight of first child	1.0	1.8	4.0	0.9	1.5	0.8	2.0	0.7	1.9	0.9
Emphysema/chronic bronchitis	1.0	1.1	2.5	-1.3	-0.6	-1.6	-0.8	-1.2	-0.6	-0.8
Medication: Ibuprofen	1.0	1.2	3.3	-1.1	-1.3	-1.1	-0.7	-0.9	-0.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	3.6	1.1	1.5	1.5	1.9	0.8	1.6	1.5
Medication: Lisinopril	1.0	1.3	2.0	1.4	1.3	0.9	1.0	1.4	0.8	1.2
Heart disease (siblings)	1.0	1.2	3.2	0.9	1.2	0.9	0.8	1.0	1.8	0.6
Leg fat mass (left)	1.0	3.8	7.7	0.7	2.4	1.5	2.0	0.6	2.5	2.8
Bipolar Disorder (2018)	0.9	1.4	2.0	-1.1	-1.4	-1.3	-1.3	0.0	-1.4	-1.2
Worry (Nagel 2018)	0.9	1.9	5.5	-0.7	-1.8	-1.1	-1.0	-1.1	-2.3	-1.0
HbA1C	0.9	1.1	1.7	1.1	1.1	0.9	1.1	1.1	0.4	1.3
Respiratory disease	0.9	1.9	3.2	1.7	1.3	1.2	1.1	1.8	0.8	1.4
Vitamin and mineral supplements	0.9	1.3	2.4	-0.6	-1.4	-1.6	-0.8	-0.5	-1.6	-1.0
Supplements: Zinc	0.9	0.9	3.4	0.7	1.0	0.7	0.9	0.5	1.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.9	1.2	1.0	1.4	0.9	1.2	0.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	1.9	1.0	1.2	1.4	1.2	0.8	1.4	1.3
Heart disease (mother)	0.9	1.1	2.2	0.6	1.2	0.5	1.2	0.7	1.5	1.1
Leg fat mass (right)	0.9	3.4	6.7	0.6	2.3	1.4	1.9	0.5	2.5	2.6
Age at last live birth	0.9	1.3	1.9	1.3	0.9	1.3	0.8	1.4	1.3	0.9
Smoking status: Previous	0.9	1.3	2.3	1.2	1.2	1.5	0.5	1.2	0.8	1.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.6	-0.8	-1.1	-1.3	-0.6	-1.1	-1.2	-1.1
Loneliness, isolation	0.9	1.2	2.4	1.6	0.7	1.0	1.2	1.6	-0.2	0.8
Diabetes diagnosed by doctor	0.9	1.5	3.0	1.1	1.3	1.1	0.8	0.9	1.7	1.4
Back pain experienced in last month	0.9	1.3	1.7	-1.1	-1.2	-1.3	-0.9	-1.2	-1.2	-0.9
BMI	0.8	4.8	7.3	1.4	2.6	1.9	2.3	1.5	2.7	2.6
Cardiovascular Disease	0.8	2.8	3.3	1.5	1.6	1.7	1.8	1.4	1.8	1.8
Past tobacco smoking	0.8	1.4	2.2	-1.2	-1.5	-1.4	-0.5	-1.2	-0.8	-1.3
Had menopause	0.8	1.0	3.5	0.2	1.3	0.3	0.5	0.3	1.9	1.0
Forced vital capacity (FVC)	0.8	2.9	6.7	1.1	1.8	1.7	2.6	1.1	1.7	1.5
Hip circumference	0.8	3.7	6.3	0.9	2.3	1.7	2.1	0.8	2.3	2.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	1.2	0.6	0.9	1.1	1.3	0.6	0.6
Neck or shoulder pain in last month	0.8	1.1	2.4	-0.9	-1.6	-0.9	-0.6	-0.9	-0.9	-1.1
Chest pain or discomfort	0.8	1.2	2.1	-1.4	-0.8	-1.1	-0.7	-1.5	-0.4	-1.3
Illnesses of siblings: Diabetes	0.8	1.0	1.6	1.0	1.1	1.1	0.9	0.5	1.3	0.7
Schizophrenia (2018)	0.7	1.5	4.0	-2.0	-1.2	-1.6	-1.0	0.0	-0.4	-1.2
Breast Cancer	0.7	1.7	4.8	0.5	1.1	0.6	2.2	0.7	2.0	0.9
Blood White Count	0.7	5.2	8.0	2.0	2.3	2.6	2.4	1.6	1.9	2.8
Diabetes (father)	0.7	0.8	1.2	-0.9	-0.9	-0.9	-0.7	-1.0	-1.1	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.0	0.7	1.0	1.0	2.0	0.9	1.5	0.8
Waist circumference	0.7	2.7	5.1	0.3	1.9	1.3	1.8	0.3	2.2	2.3
Nervous feelings	0.7	1.2	2.7	-0.8	-1.5	-0.9	-0.8	-1.0	-1.6	-0.6
Medication: Simvastatin	0.7	1.0	1.5	1.1	0.8	1.1	0.8	1.2	1.0	0.8
Arm fat mass (right)	0.7	2.9	5.2	0.6	2.1	1.3	1.7	0.6	2.3	2.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	0.9	0.8	1.5	0.3	0.7	0.3	1.2
Medication: Amlodipine	0.7	0.9	2.3	0.7	1.3	0.6	0.4	0.6	1.5	1.1
Forced vital capacity (FVC), Best measure	0.7	2.5	4.8	1.3	1.5	1.9	2.2	1.1	1.4	1.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	4.0	-0.4	-0.2	0.2	-2.0	-0.3	-1.1	-0.4
Medication for cholesterol	0.7	1.0	1.7	0.8	1.0	1.1	1.3	0.6	1.2	0.9
Medication: Paracetamol	0.7	1.1	2.2	-1.1	-0.9	-1.1	-0.8	-0.7	-1.5	-0.8
Risk taking	0.7	1.0	2.7	1.5	0.7	1.1	0.2	1.7	0.0	0.5
Age started oral contraceptive pill	0.7	0.8	1.5	-1.1	-0.9	-1.2	-0.3	-1.2	0.2	-0.8
Blood Eosinophil Count	0.6	4.3	5.2	2.1	2.3	1.8	2.3	1.9	1.9	2.3
Medication for hormone replacement therapy	0.6	0.6	1.4	0.1	-0.7	-0.6	-1.2	0.3	-1.2	-0.8
Serious illness, injury or assault to yourself	0.6	0.7	1.2	1.1	0.7	1.0	-0.5	1.1	0.9	0.2
Supplements: Glucosamine	0.6	0.7	1.3	0.3	1.2	0.9	0.8	0.4	1.0	1.0
Alcohol intake versus 10 years previously	0.6	0.9	1.8	0.4	1.4	0.4	0.8	0.2	1.3	1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.6	-0.6	-1.2	-1.1	-1.2	-0.5	-1.0	-1.2
Medication: Lansoprazole	0.6	0.7	1.6	-0.1	1.0	0.1	1.2	-0.2	1.0	1.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-1.1	-0.6	-1.1	-0.7	-0.9	-0.3	-0.7
Mean time to correctly identify matches	0.6	1.2	2.8	-1.7	-0.4	-1.0	-1.0	-1.6	0.5	-0.6
Smoking status: Current	0.6	1.0	1.6	1.1	1.3	0.9	0.8	1.0	1.0	1.0
Arm fat mass (left)	0.6	2.6	5.4	0.4	2.0	1.2	1.7	0.4	2.3	2.1
Medication: Atorvastatin	0.6	0.7	1.3	1.1	1.2	0.6	0.6	1.1	0.4	0.6
Alcohol drinker status: Never	0.6	0.8	1.2	0.7	1.1	0.9	0.9	0.8	1.1	0.4
Prostate Cancer	0.5	0.8	1.2	-1.0	-0.7	-1.1	-0.8	-1.0	-0.8	-0.7
Crohns Disease (2012)	0.5	0.7	1.5	1.0	0.8	1.1	0.8	0.0	0.7	1.2
Allergy or Eczema	0.5	1.4	3.1	0.9	0.8	1.0	1.8	1.1	1.5	0.7
Hand grip strength (left)	0.5	1.3	3.7	0.5	1.0	0.9	1.9	0.3	1.2	1.3
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.1	1.0	1.0	0.9	0.8	1.1	0.4	0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	0.8	0.7	0.6	-0.1	1.0	1.0	0.1
Severe depression (siblings)	0.5	0.6	1.2	-0.7	-1.1	-0.3	-0.5	-0.8	-0.7	-1.1
Impedance of arm (right)	0.5	2.4	5.2	-1.1	-1.7	-1.3	-1.4	-0.9	-2.3	-1.7
Tense / ‘highly strung’	0.5	0.9	1.5	-0.4	-1.2	-1.1	-0.2	-0.5	-1.2	-1.2
Hair/balding pattern: Pattern 4	0.5	1.3	2.0	-1.2	-1.4	-1.1	-0.8	-1.4	-1.0	-0.7
Peak expiratory flow (PEF)	0.5	1.1	1.8	0.8	1.2	0.9	1.3	0.8	1.4	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	1.1	0.8	0.8	0.8	0.9	0.4	0.9
Had major operations	0.5	0.6	2.8	-0.6	0.4	0.0	0.7	-0.8	1.7	-0.2
Illnesses of father: Heart disease	0.5	0.7	1.0	1.0	0.9	1.0	0.7	1.0	0.3	0.9
Hearing aid user	0.5	0.5	1.3	0.6	0.8	0.4	1.1	0.7	0.8	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	0.3	0.8	0.3	1.2	0.3	1.0	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.9	-0.8	-1.3	-0.9	-1.2	-0.9	-1.7	-1.2
Basal cell carcinoma (self-reported)	0.5	0.7	1.0	0.9	0.7	1.0	0.6	0.6	0.7	1.0
Triglycerides	0.4	0.7	1.2	1.0	1.1	1.1	0.4	1.0	0.2	0.8
Hypothyroidism (self reported)	0.4	1.0	1.8	1.1	0.7	0.8	1.2	1.4	-0.0	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	0.6	0.6	0.2	0.1	0.9	1.2	0.5
Current tobacco smoking	0.4	0.7	1.1	0.8	1.1	0.7	0.6	0.6	0.9	1.0
Maternal smoking around birth	0.4	0.6	1.8	-0.1	1.3	0.4	0.3	-0.0	0.6	1.3
High blood pressure	0.4	1.0	2.0	0.6	1.2	0.7	0.9	0.7	1.4	1.2
Alcohol usually taken with meals	0.4	0.7	1.3	0.9	0.1	0.6	1.1	1.1	1.1	-0.5
Financial difficulties in last 2 years	0.4	0.5	1.4	-0.3	-0.6	-0.1	-1.2	0.1	-1.2	-0.5
Heart attack	0.4	0.5	1.2	0.5	1.1	0.8	0.1	0.2	0.3	1.0
Illnesses of siblings	0.4	0.6	2.1	-0.1	-0.9	-0.6	-0.4	-0.1	-1.4	-0.7
Blood clot in the leg (DVT)	0.4	0.5	1.1	-0.7	-0.3	-0.4	-1.1	-0.8	-0.4	-0.8
Gout (self-reported)	0.4	0.5	2.4	-0.4	0.8	-0.3	0.6	-0.1	1.6	0.3
Leg pain on walking	0.4	0.5	1.2	0.1	0.7	0.4	1.0	0.6	1.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	-0.9	-0.5	-0.7	0.2	-1.2	0.2	-0.5
Diastolic blood pressure, automated reading	0.4	1.3	2.0	-1.3	-1.1	-1.4	-0.5	-1.4	-0.8	-1.0
Coronary Artery Disease (CAD)	0.3	0.3	0.8	0.4	0.5	0.6	0.6	0.0	0.4	0.9
HDL Cholesterol	0.3	0.5	1.1	-0.9	-0.5	-0.7	-0.2	-1.1	0.3	-0.6
Neuroticism (2016)	0.3	0.4	1.0	1.0	0.4	0.6	1.0	0.0	-0.2	0.7
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.9	0.9	0.4	0.3	0.9	-0.0	0.2
Systolic Blood Pressure	0.3	1.3	5.0	0.0	-1.2	-1.3	-0.6	0.1	-2.2	-0.9
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.8	0.7	0.6	0.4	0.6	0.5	0.6
Pack years adult smoking proportion	0.3	0.5	0.9	-0.7	-0.4	-1.0	-0.5	-0.6	-1.0	-0.5
Impedance of leg (right)	0.3	1.5	3.1	-1.1	-1.5	-1.1	-1.1	-0.9	-1.8	-1.1
Trunk fat percentage	0.3	1.1	2.3	-0.1	1.3	0.5	1.0	0.1	1.5	1.5
Age when periods started (menarche)	0.3	0.7	2.1	-0.8	-0.6	-0.2	-1.5	-0.7	0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-1.0	0.3	-0.7	0.5	-0.8	-0.0	0.4
Medication: Atenolol	0.3	0.3	0.9	-0.4	-0.5	-0.6	-0.9	-0.2	-0.2	-0.8
Impedance of leg (left)	0.3	1.4	3.3	-1.0	-1.5	-0.8	-1.2	-0.9	-1.8	-0.9
Qualifications: None of the above	0.3	0.6	0.9	-0.7	-0.6	-0.7	-0.8	-0.9	-0.8	-0.6
Neuroticism score	0.3	0.5	3.1	-0.1	-0.6	-0.2	0.0	-0.5	-1.8	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.9	0.5	1.0	1.0	1.7	0.5	1.1	0.8
Happiness	0.3	0.3	0.8	0.9	0.3	0.6	0.6	0.7	0.2	0.5
Lung cancer (father)	0.3	0.3	0.6	0.2	0.8	0.4	0.6	0.1	0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.8	0.7	0.9	1.3	1.4	0.5	0.9	0.8
Impedance of arm (left)	0.3	1.4	2.7	-0.8	-1.3	-1.0	-0.9	-0.5	-1.6	-1.6
Exposure to tobacco smoke at home	0.3	0.4	0.7	0.5	0.6	0.7	-0.8	0.6	0.3	0.6
Glaucoma (self-reported)	0.3	0.3	0.7	0.8	0.7	0.4	0.2	0.8	0.4	0.6
Number of children fathered	0.3	0.4	0.7	0.8	0.3	-0.0	0.8	0.9	0.6	-0.2
Migraine (self-reported)	0.3	0.3	0.5	0.6	0.6	0.7	0.5	0.5	0.5	0.6
Pulse rate, automated reading	0.3	1.0	2.0	0.6	1.2	0.8	1.0	0.6	1.4	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	-0.9	-0.5	-0.6	-0.5	-0.7	-0.1	-0.7
Medication: Gliclazide	0.3	0.4	1.1	1.1	0.4	0.4	0.0	0.9	0.5	0.2
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.7	-0.3	-0.5	-0.5	-0.9	-0.6	0.1
Medication: Bendroflumethiazide	0.3	0.5	1.3	0.9	0.4	0.4	0.6	1.1	0.0	0.7
Irritability	0.3	0.5	1.4	-0.6	-0.5	-0.3	0.0	-0.8	-1.2	-0.7
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.0	0.6	1.0	-0.9	-0.3	0.3	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.4	1.0	0.7	0.0	0.1	0.2	1.0
Impedance of whole body	0.3	1.3	2.7	-0.8	-1.4	-0.9	-1.0	-0.6	-1.6	-1.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.4	0.5	0.7	1.0	-0.1	-0.6	1.0
Neuroticism (Nagel 2018)	0.2	0.4	2.1	-0.1	-0.5	-0.1	0.3	-0.6	-1.5	0.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	-0.0	0.4	-0.6	0.7	0.8	0.4	-0.1
Mean Putamen Volume	0.2	0.3	0.6	0.1	-0.8	-0.6	-0.5	0.2	-0.5	-0.6
Blood Red Count	0.2	2.2	5.0	1.2	1.3	1.3	2.2	1.0	1.5	1.4
Neuroticism	0.2	0.6	3.7	0.0	-0.5	-0.1	-0.3	-0.3	-1.9	-0.2
Sensitivity / hurt feelings	0.2	0.3	1.3	0.3	0.1	0.3	0.4	0.1	-1.1	0.4
Angina	0.2	0.3	0.7	0.8	0.1	0.3	0.8	0.7	-0.2	-0.0
Hand grip strength (right)	0.2	0.7	2.3	0.2	0.8	0.5	1.5	0.2	0.9	0.7
Average weekly fortified wine intake	0.2	0.3	0.8	0.4	0.0	0.1	0.9	0.5	0.8	0.1
Fed-up feelings	0.2	0.3	0.9	0.4	0.1	0.4	0.6	-0.1	-0.9	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.0	1.0	0.5	0.6	0.4	0.9	-0.1	0.2
Hearing difficulty/problems with background noise	0.2	0.4	1.5	0.3	0.9	0.3	0.0	0.3	1.2	0.1
Medication: Ramipril	0.2	0.2	0.9	0.5	0.2	0.1	-0.4	0.9	-0.4	0.1
Time employed in main current job	0.2	0.2	0.5	-0.7	-0.4	-0.5	0.3	-0.7	0.1	-0.4
Father’s age at death	0.2	0.2	0.6	-0.1	0.4	0.2	0.8	-0.2	0.7	0.2
Worrier / anxious feelings	0.2	0.4	1.6	0.4	0.2	0.5	1.3	-0.0	-0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	0.8	0.7	0.9	0.8	0.6	0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.2	-0.2	-0.6	-0.5	0.2	-0.1	0.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	-0.5	0.1	0.5	0.5	-0.5	0.6	0.2
Medication: Paracetamol	0.2	0.4	1.1	-0.7	-0.6	-0.7	-0.3	-0.4	-1.0	-0.3
Body fat percentage	0.2	0.7	1.6	-0.3	1.0	0.2	0.7	-0.1	1.3	1.2
Exposure to tobacco smoke outside home	0.2	0.2	0.6	0.3	0.5	0.6	-0.2	0.2	0.8	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.5	-0.0	0.2	0.8	0.4	-0.6	0.3
Health satisfaction	0.2	0.2	0.4	0.6	0.5	0.6	0.4	0.4	0.4	0.4
Qualifications: College or University degree	0.2	0.7	1.5	1.1	0.7	0.5	0.8	1.2	0.7	-0.1
Alcohol intake frequency.	0.2	0.4	1.7	-0.3	0.6	0.4	0.5	-0.5	1.3	0.4
Family relationship satisfaction	0.2	0.2	0.4	0.4	0.0	0.6	-0.1	0.6	-0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.3	0.1	0.7	-0.4	0.3	-0.5	0.6
Hypertension (Self-reported)	0.2	0.6	1.6	0.3	0.9	0.3	0.8	0.5	1.3	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.1	0.6	-0.1	0.5	0.2	0.5	0.6
Mood swings	0.2	0.3	0.8	0.1	0.3	0.4	0.7	-0.4	-0.9	0.8
Ever had bowel cancer screening	0.2	0.2	0.5	0.1	0.5	0.3	0.3	0.1	0.6	0.7
Friendships satisfaction	0.2	0.3	0.7	-0.6	-0.5	-0.6	-0.6	-0.3	-0.8	-0.1
Guilty feelings	0.2	0.3	1.6	0.1	-0.2	-0.3	-0.1	0.3	-1.3	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.1	-0.4	-0.6	-0.2	-0.0	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.4	0.4	0.8	-0.2	0.5	0.1	0.3
Cholesterol lowering medication	0.2	0.3	0.5	0.5	0.5	0.6	0.3	0.7	0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.5	-0.1	-0.3	-0.9	-0.5	-0.2	-0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.2	0.3	0.5	-0.1	0.5	0.3	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	0.5	0.2	0.9	0.0	0.5	0.2	0.2
Crohns Disease (2017)	0.1	0.2	0.7	-0.2	-0.5	-0.1	-0.5	-0.1	-0.8	-0.2
Ovarian Cancer	0.1	0.1	0.2	0.4	0.1	0.4	-0.2	0.4	0.4	0.4
Age at First Birth	0.1	0.2	0.6	-0.6	-0.1	-0.0	-0.3	-0.8	0.1	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	-0.5	-0.5	-0.0	0.0	-0.3	-0.6
Ulcerative Colitis	0.1	0.2	0.4	0.0	0.6	0.5	0.4	0.0	0.2	0.6
Blood Platelet Count	0.1	0.7	1.9	0.0	0.6	0.9	1.2	0.1	0.6	1.4
Waist Hip Ratio (WHR)	0.1	0.6	1.6	-0.4	0.7	0.6	0.8	-0.3	1.2	0.8
Lung FEV1/FVC ratio	0.1	0.6	1.6	-1.3	-0.2	-0.8	-0.8	-1.2	0.3	-0.5
Average weekly spirits intake	0.1	0.1	0.3	-0.2	-0.1	-0.4	0.4	0.0	0.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.1	0.4	0.3	0.3	0.1	0.4	0.2
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.3	0.2	-0.3	-0.6	0.3	-0.7	0.4
Stomach or abdominal pain in last month	0.1	0.2	0.5	-0.3	-0.1	-0.4	0.2	-0.5	-0.7	-0.4
Body mass index (BMI)	0.1	0.6	1.6	-0.1	0.9	0.2	0.7	-0.1	1.3	1.1
Number of incorrect matches in round	0.1	0.2	0.5	-0.4	-0.2	-0.7	-0.5	-0.3	-0.1	-0.5
Falls in the last year	0.1	0.1	0.5	-0.1	-0.0	0.1	-0.7	-0.2	0.4	0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.4	0.1	-0.4	-0.6	0.7	0.3	-0.2
Depression (self-reported)	0.1	0.1	0.4	-0.4	-0.4	-0.2	-0.2	-0.7	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.8	0.3	-0.1	0.1	0.9	0.1	-0.6	0.2
Headache pain in last month	0.1	0.2	0.4	0.4	0.5	0.6	0.5	0.4	0.3	0.2
Birth weight	0.1	0.2	0.7	-0.5	0.2	0.5	-0.2	-0.7	0.8	-0.1
High blood pressure (siblings)	0.1	0.1	0.2	-0.4	-0.1	-0.0	-0.3	-0.4	0.3	-0.1
Leg fat percentage (right)	0.1	0.3	0.9	-0.4	0.6	-0.1	0.3	-0.3	0.8	0.9
Worry too long after embarrassment	0.1	0.2	1.1	0.3	0.3	-0.1	1.0	-0.1	-0.3	0.2
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.6	-0.1	0.2	0.2	0.4	-0.4	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.6	-0.4	-0.0	0.3	-0.5	-0.3	-0.8	0.1
Shortness of breath walking on level ground	0.1	0.2	0.6	0.1	0.6	-0.4	-0.1	0.2	0.7	0.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.1	0.3	0.5	0.3	-0.3	0.2	0.6
Angina (self-reported)	0.1	0.2	0.5	0.6	0.0	0.1	0.7	0.6	-0.3	-0.1
Medication: Omeprazole	0.1	0.1	0.2	0.5	0.2	0.3	0.2	0.4	-0.5	0.4
Medication: Seretide 50 evohaler	0.1	0.2	0.6	-0.2	-0.0	-0.7	-0.2	0.3	-0.2	-0.6
Overall health rating	0.1	0.3	0.9	0.0	-0.2	0.1	-0.8	-0.4	-0.9	0.6
Arm fat percentage (left)	0.1	0.3	0.7	-0.5	0.6	-0.2	0.2	-0.2	0.9	0.6
Average weekly red wine intake	0.1	0.2	0.5	0.1	-0.4	-0.0	-0.5	0.3	-0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	0.4	0.3	0.1	0.0	0.6	0.7	-0.3
Breast cancer (self-reported)	0.1	0.2	0.5	0.6	0.1	0.3	0.4	0.7	0.0	0.3
Osteoporosis (self-reported)	0.1	0.1	0.5	0.0	-0.0	-0.4	0.7	0.1	-0.0	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.1	0.1	-0.6	0.3	-0.2	0.6	-0.0
Miserableness	0.1	0.3	1.0	-0.5	-0.0	0.1	0.4	-1.0	-0.5	0.4
Financial situation satisfaction	0.1	0.1	0.3	0.3	-0.0	0.1	0.5	0.4	-0.2	-0.1
Medication: Blood pressure	0.1	0.2	0.6	-0.6	-0.4	-0.8	-0.3	-0.3	-0.4	-0.1
Ever smoked	0.1	0.2	0.3	0.4	0.5	0.3	-0.4	0.5	-0.3	0.4
Leg fat percentage (left)	0.1	0.4	1.2	-0.3	0.6	0.1	0.3	-0.3	0.8	1.1
Average weekly beer plus cider intake	0.1	0.1	0.7	-0.3	-0.1	-0.1	-0.9	-0.5	-0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.3	-0.2	-0.0	0.3	0.2	-0.7	0.2
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.5	0.1	0.2	-0.5	-0.5	-0.0	0.3
Pack years of smoking	0.1	0.1	0.4	-0.4	-0.0	-0.7	-0.1	-0.4	-0.4	-0.2
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.0	-0.2	0.4	-0.2	-0.2	-0.0	-0.1
Irritable Bowel Disease (IBD)	0.0	0.0	0.2	0.1	0.1	0.0	-0.1	0.2	-0.5	0.1
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.1	0.2	-0.3	0.0	0.2	-0.4	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.4	0.3	-0.5	-0.1	0.2	-0.0	-0.7	0.5
Lung FVC	0.0	0.1	0.4	0.1	0.1	0.4	0.3	0.3	0.6	0.1
Chronotype (morning person)	0.0	0.1	0.2	-0.0	-0.0	-0.0	-0.3	0.1	0.4	-0.3
Hair Pigment	0.0	0.8	1.4	-0.7	-1.1	-1.2	-0.3	-0.5	-1.1	-0.9
Tanning	0.0	0.5	2.0	-0.6	-0.1	-0.1	-1.4	-0.6	0.5	-0.6
Mouth/teeth dental problems	0.0	0.0	0.2	0.1	0.1	-0.1	0.2	0.2	0.4	-0.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.2	0.0	-0.0	-0.1
Arm fat percentage (right)	0.0	0.2	0.4	-0.6	0.3	-0.4	-0.0	-0.4	0.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.3	-0.1	0.0	0.1	-0.1	-0.5	-0.2	0.5
Pulse rate	0.0	0.1	0.1	0.1	0.4	-0.3	0.3	0.3	0.3	0.0
Illnesses of mother	0.0	0.1	0.1	0.2	0.3	0.4	-0.3	0.2	0.1	0.1
Comparative body size at age 10	0.0	0.1	0.2	-0.4	0.2	-0.1	0.2	-0.4	0.5	-0.0
Age at first live birth	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2	0.0	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.1	0.0	0.4	0.4	0.3	-0.2	0.0
Mother’s age at death	0.0	0.0	0.1	-0.2	0.0	-0.4	-0.0	-0.1	0.2	-0.3
Fractured/broken bones in last 5 years	0.0	0.1	0.1	0.2	0.2	-0.1	-0.0	0.4	0.2	-0.3
Commuting to job workplace: Cycle	0.0	0.0	0.2	0.2	0.0	-0.0	0.4	-0.2	-0.2	-0.0

Hub : Genes

MTMR9L

Models

Trait associations