Hub : Genes

FAM167B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.4270	0.1150	7.0e-04	-0.004	NA	-0.009	NA	0.001	4.4e-01	NA	7.5e-01	NA	3.0e-01
2	GTEx	Cells EBV-transformed lymphocytes	0.3810	0.1000	2.0e-06	0.323	NA	0.310	NA	0.311	3.2e-11	NA	8.9e-11	NA	8.2e-11
3	GTEx	Whole Blood	0.1130	0.0550	6.3e-04	0.100	NA	0.070	NA	0.072	1.6e-09	NA	4.6e-07	NA	3.4e-07
4	ROSMAP	Brain Pre-frontal Cortex	0.0487	0.0243	2.7e-02	0.036	0.002	0.022	0.009	0.030	1.6e-05	0.1500	6.7e-04	0.024	9.1e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0499	0.0273	8.9e-04	0.040	0.014	0.027	NA	0.030	2.4e-05	0.0093	4.1e-04	NA	2.5e-04
6	TCGA	Thyroid Carcinoma	0.0290	0.0180	2.2e-03	0.006	0.023	0.009	NA	0.005	7.1e-02	0.0024	4.2e-02	NA	9.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.8	1.3	0.7	-1.1	-1.0	0.2	1.0	0.9
Bipolar Disorder or Schizophrenia	1.5	3.6	5.1	1.6	-2.2	-2.3	-1.2	2.3	1.4
Depressed Affect (Nagel 2018)	0.2	0.4	1.5	-1.2	0.5	0.5	-0.3	-0.5	-0.5
Depression (Nagel 2018)	2.1	3.1	4.5	-0.7	2.0	2.0	-1.5	-1.9	-2.1
Intelligence (Savage-Jansen 2018)	1.4	4.3	7.4	1.8	2.4	2.1	0.5	-2.2	-2.7
Neuroticism (Nagel 2018)	0.0	0.1	0.4	-0.7	-0.1	-0.0	-0.3	-0.1	0.3
Schizophrenia (2018)	1.5	3.2	4.6	1.5	-2.0	-2.1	-1.7	2.1	1.1
Schizophrenia vs Biploar Disorder	1.5	1.9	3.4	-0.3	-1.7	-1.8	0.0	1.8	1.5
Worry (Nagel 2018)	0.2	0.4	1.4	0.3	-0.7	-0.7	-0.1	0.4	1.2
Alzheimer’s Disease (in mother)	0.4	0.4	1.8	0.7	0.0	0.2	1.4	-0.1	-0.4
Alzheimer’s Disease (in father)	0.9	1.0	3.3	1.5	-0.0	-0.0	1.8	-0.2	-0.2
Alzheimer’s Disease (including proxy)	1.1	1.6	5.6	1.8	0.2	0.4	2.4	-0.5	-0.6
Crohns Disease (2017)	0.1	0.3	1.3	0.2	-0.2	-0.2	1.1	0.2	0.1
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.1	0.2	0.1	-0.0	-0.2	0.0
Ulcerative Colitis (UC)	0.3	0.7	2.8	-0.9	0.3	0.2	-1.7	-0.2	0.4
Major Depression (MDD)	0.9	1.1	3.1	1.8	-1.0	-1.1	0.1	1.2	0.0
Reaction Time	2.2	4.2	8.2	0.8	-2.7	-2.9	-0.3	2.8	1.3
Verbal and Numeric Reasoning (VNR)	1.7	4.0	8.0	0.4	2.4	2.2	-0.1	-2.3	-2.8
Breast Cancer	0.3	0.7	1.4	1.2	0.6	0.6	0.9	-0.5	-1.0
Ovarian Cancer	0.5	0.6	2.7	-0.7	0.2	0.2	1.7	-0.3	-0.7
Prostate Cancer	1.1	1.6	4.9	-2.2	-0.9	-1.0	-0.9	1.1	1.1
Age at First Birth	0.3	0.4	1.1	-1.0	-0.6	-0.7	-0.0	0.6	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	-1.4	0.2	0.1	-0.5	-0.1	0.0
Coronary Artery Disease (CAD)	0.9	1.1	5.2	-0.1	0.5	0.4	2.3	-0.4	-0.8
Crohns Disease (2012)	0.8	1.4	2.8	1.7	0.9	0.9	1.0	-0.9	-1.3
Mean Putamen Volume	0.5	0.6	3.1	-1.8	-0.1	0.0	0.4	-0.1	0.3
Fasting Glucose	1.2	1.5	2.9	-0.6	1.3	1.4	0.5	-1.3	-1.7
HbA1C	1.0	1.1	1.5	-1.2	1.1	1.2	0.1	-1.2	-1.0
HDL Cholesterol	0.6	1.0	2.0	1.4	-0.8	-0.7	-1.3	1.0	0.5
LDL Cholesterol	0.9	1.4	2.6	-0.0	-1.5	-1.5	-0.6	1.6	1.2
Lupus	2.5	3.7	5.8	0.8	2.2	2.1	1.4	-2.1	-2.4
Neuroticism (2016)	0.5	0.8	1.2	-0.3	1.1	0.9	-1.0	-1.1	-0.5
Primary Biliary Cirrhosis	0.4	0.6	1.1	0.1	0.9	0.8	-0.9	-1.1	-0.1
Rheumatoid Arthritis	2.1	2.9	5.0	1.2	1.8	1.7	1.1	-1.9	-2.2
Schizophrenia (2014)	2.7	6.1	9.8	1.6	-2.9	-3.1	-1.6	3.1	1.9
Triglycerides	0.5	0.9	1.7	-1.3	1.1	0.9	0.4	-1.0	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.8	0.1	0.2	-0.6	-0.3	0.5
Ulcerative Colitis	0.2	0.3	1.2	-0.1	0.3	0.0	-1.1	-0.1	-0.4
Blood Eosinophil Count	0.5	4.1	5.6	-1.5	2.4	2.1	-2.0	-2.2	-1.9
Blood Platelet Count	0.1	1.0	3.6	1.9	0.3	0.2	0.8	-0.1	-1.1
Blood Red Count	0.1	1.4	1.7	1.1	1.3	1.3	1.1	-1.1	-1.3
Blood White Count	0.7	5.0	7.9	2.8	2.1	1.8	1.9	-1.9	-2.7
Heel T-Score	0.1	0.8	4.5	-2.1	0.2	0.3	0.5	-0.3	-0.2
BMI	0.4	2.6	5.9	-0.4	1.5	1.3	-1.9	-1.3	-2.4
Height	1.3	24.6	45.3	6.4	4.9	4.5	0.3	-4.2	-6.7
Waist Hip Ratio (WHR)	0.1	0.5	1.3	0.1	-0.4	-0.5	0.9	0.5	-1.1
Systolic Blood Pressure	0.1	0.4	2.1	0.5	0.1	0.3	0.3	-0.1	1.4
Smoking Status	1.5	3.6	5.3	1.7	2.3	2.1	-0.4	-2.0	-2.2
Allergy or Eczema	0.6	1.6	6.0	0.7	0.7	0.8	2.4	-0.8	-1.1
Cardiovascular Disease	0.6	1.9	3.5	-0.9	1.5	1.5	0.9	-1.5	-1.9
Hypothyroidism (self reported)	0.4	1.0	1.4	-0.9	1.1	1.2	-0.8	-1.1	-0.8
Respiratory disease	1.3	2.9	7.3	-0.6	1.5	1.6	2.7	-1.5	-1.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.8	-0.1	1.1	1.0	-0.0	-1.0	-1.7
Lung FEV1/FVC ratio	0.2	1.0	1.8	1.0	-1.1	-1.4	-0.4	1.2	0.6
Lung FVC	0.1	0.7	3.2	-0.8	0.2	0.1	1.8	-0.2	-0.3
Neuroticism	0.0	0.1	0.2	0.0	-0.0	0.0	-0.4	-0.1	0.4
Chronotype (morning person)	0.2	0.4	1.5	1.1	0.1	-0.0	-1.2	0.0	-0.0
Hair Pigment	0.1	1.9	9.0	-3.0	-0.8	-0.6	-0.1	0.6	1.1
Tanning	0.1	0.9	3.1	-0.4	-0.8	-0.8	-1.8	1.0	0.1
Hand grip strength (left)	0.6	1.6	5.8	2.4	0.9	0.7	-1.4	-0.6	-0.8
Number of treatments/medications taken	1.9	3.3	4.9	-2.2	1.8	1.8	1.3	-1.7	-2.0
Average weekly spirits intake	0.1	0.1	0.3	0.5	-0.1	-0.1	0.5	0.1	0.3
Sensitivity / hurt feelings	0.3	0.5	1.7	0.9	0.4	0.4	1.3	-0.3	-0.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.5	-1.4	1.1	1.0	-1.6	-1.1	-0.7
Hearing difficulty/problems: Yes	1.2	1.8	3.1	0.0	1.8	1.7	-0.3	-1.6	-1.5
Relative age of first facial hair	1.1	2.2	3.8	0.9	1.8	2.0	0.6	-1.7	-1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	0.9	0.2	0.1	-1.3	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.2	-1.8	0.4	0.5	0.8	-0.4	-0.9
Ever had hysterectomy (womb removed)	0.7	0.8	2.4	1.6	0.7	0.8	0.7	-0.7	-0.7
Systolic blood pressure, automated reading	0.6	1.8	4.9	0.9	-1.4	-1.3	-0.3	1.4	2.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	0.1	0.7	0.8	-0.9	-0.8	-0.5
Angina	0.5	0.7	1.9	0.7	0.6	0.8	1.4	-0.8	-0.0
Medication for hormone replacement therapy	0.4	0.4	1.8	-1.3	0.1	0.2	-0.2	-0.1	0.7
Vitamin and mineral supplements	0.4	0.5	1.4	-0.8	-0.6	-0.7	-0.2	0.6	1.2
Supplements: Zinc	0.4	0.4	0.7	-0.5	0.6	0.6	-0.8	-0.6	-0.7
Medication: Co-codamol	0.8	1.0	3.0	0.3	1.0	0.9	0.3	-0.9	-1.7
Medication: Metformin	0.9	1.2	2.3	-0.5	1.3	1.3	-0.0	-1.2	-1.5
Diabetes (father)	0.9	1.2	2.9	1.7	-0.9	-0.8	0.6	0.9	1.1
Diabetes (mother)	0.8	1.1	2.6	0.6	0.9	0.7	-1.2	-0.7	-1.6
Severe depression (siblings)	0.6	0.7	2.3	1.5	-0.7	-0.7	0.0	0.5	0.7
Pack years adult smoking proportion	0.6	0.9	1.7	1.2	-0.6	-0.7	-1.3	0.8	0.9
Impedance of leg (right)	0.5	2.6	8.8	1.4	-1.1	-0.9	3.0	0.9	1.4
Leg fat-free mass (left)	1.3	6.7	14.6	1.5	2.8	2.4	-2.3	-2.3	-3.8
Trunk fat percentage	0.1	0.4	1.6	0.4	0.0	-0.1	-0.8	0.0	-1.2
Hand grip strength (right)	0.5	1.3	5.5	2.4	0.5	0.4	-1.4	-0.3	-0.2
Townsend deprivation index at recruitment	0.2	0.3	1.4	0.5	0.3	0.2	-1.2	-0.1	-0.3
Current tobacco smoking	0.4	0.6	1.8	1.3	0.8	0.6	0.0	-0.6	-0.8
Average weekly fortified wine intake	0.5	0.6	1.9	-1.4	0.4	0.4	-1.1	-0.5	-0.4
Maternal smoking around birth	1.1	1.6	8.4	2.9	0.1	-0.2	-0.5	0.4	-0.9
Fed-up feelings	0.1	0.1	0.2	-0.1	0.4	0.4	0.3	-0.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.6	-1.0	1.3	1.2	-0.0	-1.3	-1.2
Relative age voice broke	2.9	4.5	7.1	0.0	2.7	2.7	-0.0	-2.5	-2.6
Taking other prescription medications	1.2	1.9	4.8	-1.2	1.4	1.3	0.3	-1.2	-2.2
Age when periods started (menarche)	0.2	0.6	1.0	0.3	-1.0	-1.0	0.3	1.0	0.4
Bilateral oophorectomy (both ovaries removed)	3.6	4.2	7.0	0.3	2.6	2.6	0.7	-2.4	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	4.7	-1.1	2.2	2.2	1.3	-2.2	-1.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.7	0.6	0.8	0.7	-0.1	-0.8	-1.9
Qualifications: CSEs or equivalent	2.4	3.2	4.8	-0.0	-2.2	-2.2	-0.6	2.2	2.1
Serious illness, injury or assault to yourself	0.5	0.6	0.9	0.1	0.8	0.9	0.8	-1.0	-0.8
High blood pressure	0.2	0.5	1.7	-0.5	0.6	0.5	0.2	-0.5	-1.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.7	0.2	0.6	0.6	2.6	-0.6	-1.0
Multivitamins +/- minerals	0.5	0.7	1.3	0.7	0.7	0.7	1.0	-0.5	-1.1
Stomach or abdominal pain in last month	0.4	0.4	1.8	0.2	-0.1	-0.2	-1.3	0.2	0.9
Supplements: Glucosamine	0.4	0.6	1.5	1.2	0.4	0.3	-0.9	-0.4	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	0.8	-0.8	-1.0	0.7	1.0	-0.1
Medication: Atenolol	0.4	0.5	1.7	-0.8	-0.5	-0.4	1.3	0.3	0.5
Medication: Levothyroxine sodium	0.7	1.2	2.3	-0.5	1.2	1.1	0.3	-1.3	-1.5
Sitting height	2.7	19.0	29.4	4.8	4.8	4.5	-0.6	-4.3	-5.4
Chronic bronchitis/emphysema (father)	2.9	3.4	4.5	2.1	-1.9	-1.9	0.0	2.0	2.1
High blood pressure (mother)	0.7	1.0	2.2	-1.2	-0.4	-0.2	-1.4	0.2	1.5
Body mass index (BMI)	0.3	1.3	6.4	-0.5	-0.0	-0.3	-2.5	0.2	-0.9
Impedance of leg (left)	0.6	2.7	10.1	1.6	-1.0	-0.8	3.2	0.8	1.1
Leg predicted mass (left)	1.2	6.3	13.5	1.6	2.6	2.3	-2.2	-2.2	-3.7
Trunk fat mass	0.5	1.9	6.5	1.0	1.1	0.9	-1.1	-0.9	-2.6
Waist circumference	0.3	1.2	3.8	1.0	0.4	0.2	-1.5	-0.2	-2.0
Number of incorrect matches in round	0.2	0.3	1.0	-1.0	-0.5	-0.5	0.2	0.6	0.3
Past tobacco smoking	0.6	1.1	1.9	-0.4	-1.4	-1.2	0.2	1.1	1.4
Alcohol usually taken with meals	0.6	0.9	2.8	-1.7	0.5	0.9	0.8	-0.9	-0.1
Nervous feelings	0.2	0.4	0.6	-0.1	-0.7	-0.8	0.6	0.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.2	-1.1	1.1	1.0	-1.8	-1.1	-0.3
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.1	0.3	0.2	-0.5	-0.1	-0.6
Hair/balding pattern: Pattern 2	1.0	1.2	1.9	-0.9	1.3	1.4	0.5	-1.4	-0.8
Had menopause	0.3	0.4	1.1	-0.6	0.2	0.1	-0.8	0.1	-1.0
Had other major operations	1.0	1.2	3.0	-0.6	1.1	1.1	0.6	-1.1	-1.7
Forced vital capacity (FVC)	0.5	1.9	3.6	1.9	1.4	1.2	1.3	-1.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.6	5.3	-0.7	1.9	1.9	2.3	-2.0	-2.1
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.6	-2.1	1.5	1.6	-0.9	-1.6	-0.6
Qualifications: None of the above	0.7	1.4	3.1	-1.8	-0.9	-0.9	-1.6	1.0	0.6
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.9	-0.3	-0.4	0.6	0.2	0.4
Mouth/teeth dental problems	0.1	0.2	1.1	0.4	0.2	0.1	-1.1	-0.1	0.2
Heart attack	0.2	0.2	0.5	0.2	0.4	0.3	0.7	-0.2	-0.6
Allergy	1.3	3.0	11.7	0.6	-1.1	-1.1	-3.4	1.1	1.5
Pain all over the body in last month	1.8	2.0	2.7	0.6	-1.6	-1.6	-1.2	1.6	1.4
Diabetes (self-reported)	1.2	1.8	3.7	-0.6	1.5	1.5	-0.5	-1.5	-1.9
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.4	0.0	-0.0	0.6	-0.1	0.2
Medication: Ramipril	0.1	0.2	0.3	0.3	0.5	0.5	-0.3	-0.5	-0.0
Medication: Simvastatin	0.9	1.3	2.8	-0.7	1.0	1.1	1.7	-1.0	-1.1
Fluid intelligence score	0.7	1.5	4.2	-0.0	1.3	1.1	0.7	-1.2	-2.0
Illnesses of siblings	0.2	0.3	1.0	0.2	-0.2	-0.1	-0.7	0.1	1.0
Neuroticism score	0.0	0.1	0.3	-0.2	-0.1	-0.1	0.1	0.0	0.6
Weight	0.9	4.5	11.4	1.7	2.0	1.6	-1.9	-1.5	-3.4
Impedance of arm (right)	0.7	3.1	12.6	0.3	-1.2	-0.9	3.5	0.8	1.8
Arm fat percentage (right)	0.2	0.6	1.5	-0.9	-0.6	-0.7	-1.2	0.6	-0.3
Trunk fat-free mass	1.8	10.1	20.7	2.7	3.5	3.1	-1.8	-2.8	-4.5
Hip circumference	0.6	2.4	4.1	1.9	1.1	0.8	-2.0	-0.8	-2.0
Time employed in main current job	0.3	0.3	0.7	0.8	-0.5	-0.6	-0.3	0.6	0.3
Alcohol intake versus 10 years previously	0.5	0.7	2.0	-1.0	0.5	0.3	-1.4	-0.2	-1.0
Father’s age at death	0.1	0.1	0.6	0.8	-0.0	-0.1	-0.4	0.1	-0.3
Worrier / anxious feelings	0.5	1.0	4.8	-0.2	0.4	0.5	2.2	-0.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.8	1.3	-0.0	-0.2	-0.2	0.2	-0.2
Falls in the last year	0.1	0.2	0.5	0.7	-0.1	-0.2	-0.2	0.3	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.7	0.4	0.4	-0.7	-0.4	-0.3
Number of live births	3.8	5.4	8.2	1.9	2.6	2.6	1.0	-2.5	-2.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.7	1.3	0.7	0.5	1.6	-0.6	-0.5
Pulse rate	0.6	0.9	3.1	-1.8	0.1	0.1	-1.6	-0.1	-0.0
Happiness	1.2	1.4	4.7	-2.2	0.8	0.9	1.2	-0.8	-0.5
Noisy workplace	1.3	1.6	2.7	-0.3	1.5	1.5	0.3	-1.6	-1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.0	-1.0	0.8	0.9	-0.3	-0.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.8	0.5	1.2	1.4	-0.5	-1.3	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	-0.4	-0.8	-0.7	0.4	0.8	0.7
Asthma	1.7	3.4	8.0	-0.8	1.7	1.7	2.8	-1.6	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	4.1	0.9	-0.3	-0.1	2.0	0.0	0.7
Medication: Cholesterol lowering	1.0	1.6	2.5	-0.4	1.5	1.6	0.8	-1.6	-1.4
Depression (self-reported)	0.5	0.6	2.7	-1.6	-0.4	-0.5	0.1	0.4	0.2
Medication: Lansoprazole	0.4	0.5	2.3	0.1	0.1	-0.1	-1.5	0.2	-0.8
Prospective memory result	0.7	0.9	3.2	-0.5	-0.9	-0.7	0.5	0.7	1.8
Lung cancer (father)	0.1	0.1	0.2	-0.3	0.3	0.1	-0.4	0.0	-0.5
Illnesses of mother	0.1	0.1	0.2	0.0	0.2	0.3	0.5	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.5	1.9	0.8	0.7	1.6	-0.7	-0.4
Pulse wave Arterial Stiffness index	3.6	4.2	11.5	1.0	2.1	1.9	1.1	-1.9	-3.4
Impedance of arm (left)	0.6	2.6	12.0	0.5	-1.0	-0.7	3.5	0.5	1.4
Arm fat mass (right)	0.3	1.2	3.5	0.4	0.7	0.5	-1.6	-0.4	-1.9
Trunk predicted mass	1.8	10.0	20.5	2.7	3.4	3.0	-1.8	-2.8	-4.5
Standing height	1.9	18.8	31.5	5.2	4.5	4.2	1.0	-4.0	-5.6
Length of working week for main job	3.0	3.3	6.9	-0.0	-1.8	-1.7	-1.8	1.9	2.6
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.1	0.5	0.4	-0.9	-0.4	-0.8
Breastfed as a baby	1.2	1.5	5.3	0.5	1.0	1.0	0.7	-1.0	-2.3
Tense / ‘highly strung’	0.3	0.6	1.4	-1.2	-0.5	-0.4	-0.4	0.2	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.8	-2.2	0.4	0.4	0.1	-0.5	0.0
Hair/balding pattern: Pattern 4	0.6	1.5	4.0	0.5	-1.3	-1.2	2.0	1.1	0.8
Birth weight of first child	0.6	1.2	2.7	0.7	1.1	1.0	-1.6	-0.9	-0.9
Peak expiratory flow (PEF)	0.4	0.9	2.0	1.4	1.0	0.8	0.9	-0.8	-0.5
Pulse wave reflection index	1.7	2.0	7.0	0.7	1.4	1.2	0.3	-1.1	-2.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-0.2	0.8	0.8	1.2	-0.8	-1.2
Loud music exposure frequency	1.3	1.4	3.0	-0.4	1.2	1.2	0.9	-1.4	-1.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.3	0.4	1.1	1.2	0.0	-1.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.5	-0.4	-0.5	0.2	0.4	-0.2
Blood clot in the leg (DVT)	0.9	1.1	3.7	-1.9	-0.9	-0.9	-0.0	0.9	0.8
Medication: Paracetamol	0.4	0.6	1.8	0.3	-0.7	-0.7	1.3	0.7	0.5
Headache pain in last month	0.1	0.2	0.3	-0.4	0.5	0.5	-0.2	-0.6	0.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.2	1.2	-1.4	-1.5	-0.5	1.4	1.4
Glaucoma (self-reported)	0.3	0.3	0.6	0.2	0.7	0.6	0.1	-0.7	-0.8
Gout (self-reported)	0.5	0.7	3.1	-1.8	-0.5	-0.7	0.1	0.5	-0.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	3.2	-1.2	1.7	1.8	-0.4	-1.8	-1.4
Medication: Amlodipine	0.5	0.6	1.4	-0.5	0.6	0.5	-1.2	-0.5	-1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.1	-0.7	1.1	1.0	0.6	-0.9	-0.7
Birth weight	0.1	0.2	0.3	0.4	-0.5	-0.5	0.1	0.6	-0.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.6	1.3	-0.9	-0.9	-1.0	1.0	0.6
High blood pressure (siblings)	0.3	0.4	1.4	-1.2	-0.5	-0.5	0.8	0.4	-0.1
Forced vital capacity (FVC), Best measure	0.7	2.7	5.9	2.4	1.5	1.3	1.9	-1.3	-1.0
Body fat percentage	0.1	0.4	1.4	-0.1	-0.2	-0.3	-1.2	0.3	-1.0
Leg fat percentage (right)	0.2	0.6	2.4	-0.2	-0.3	-0.5	-1.6	0.4	-0.7
Arm fat-free mass (right)	2.1	10.7	23.2	2.4	3.5	3.1	-2.4	-2.9	-4.8
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.8	0.0	0.0	0.2	-0.2	-0.6
Comparative body size at age 10	0.1	0.3	0.6	-0.8	-0.3	-0.5	-0.7	0.3	-0.2
Number of full brothers	2.7	3.5	5.4	0.1	-2.2	-2.2	-0.8	2.3	2.2
Worry too long after embarrassment	0.1	0.1	0.2	0.4	0.5	0.4	-0.2	-0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	-0.9	0.5	0.6	1.2	-0.6	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	-1.0	0.5	0.5	1.1	-0.5	0.0
Number of children fathered	0.8	0.9	3.3	0.4	0.8	0.9	-1.8	-0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	1.0	-0.3	-0.3	0.9	0.4	0.0
Age at first live birth	0.6	1.0	5.4	-2.3	-0.1	-0.1	-0.6	-0.1	0.3
Pulse wave peak to peak time	2.7	3.2	9.3	-0.8	-1.7	-1.5	-1.1	1.6	3.0
Health satisfaction	0.8	1.0	4.3	-2.1	0.6	0.5	1.0	-0.5	-0.3
Shortness of breath walking on level ground	0.0	0.0	0.1	0.1	-0.1	-0.1	0.3	0.1	-0.2
Qualifications: College or University degree	0.4	1.4	3.9	-2.0	1.0	1.2	0.7	-1.1	-0.2
Eye problems/disorders: None of the above	1.3	1.5	4.5	-0.9	-0.9	-0.9	-2.1	0.9	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	-1.0	-0.5	-0.5	-0.1	0.5	0.1
Emphysema/chronic bronchitis	1.1	1.2	2.2	0.9	-1.3	-1.4	-0.0	1.5	0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	3.3	1.1	0.3	0.2	-1.8	-0.2	-0.3
Neck or shoulder pain in last month	0.6	0.9	1.6	-1.3	-1.0	-0.8	0.7	0.8	0.9
Medication: Blood pressure	0.8	1.4	2.4	-0.4	1.4	1.4	-0.3	-1.3	-1.5
Angina (self-reported)	0.4	0.5	1.5	0.6	0.4	0.6	1.2	-0.6	0.1
Migraine (self-reported)	0.3	0.4	0.6	0.4	0.5	0.6	0.5	-0.8	-0.7
Medication: Ibuprofen	1.1	1.3	2.7	0.5	-1.1	-1.0	1.6	0.9	1.5
Medication: Allopurinol	0.9	1.2	3.0	-1.7	0.9	0.6	-0.1	-0.8	-1.6
Medication: Omeprazole	0.6	0.7	3.4	-1.9	0.4	0.5	0.3	-0.4	-0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.8	-0.1	-0.2	-0.9	0.3	0.4
Mean time to correctly identify matches	0.9	1.7	3.7	-0.0	-1.8	-1.9	-0.0	1.7	0.2
Heart disease (mother)	0.4	0.4	1.3	-0.6	0.7	0.5	0.0	-0.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	6.6	-1.6	2.4	2.4	0.8	-2.2	-2.6
Whole body fat mass	0.5	1.9	5.6	0.9	1.0	0.7	-1.7	-0.7	-2.4
Leg fat mass (right)	0.4	1.6	4.5	0.5	0.8	0.4	-2.0	-0.5	-2.1
Arm predicted mass (right)	1.9	9.9	22.1	2.3	3.3	2.9	-2.2	-2.7	-4.7
Pulse rate, automated reading	0.1	0.5	1.5	-0.2	0.8	0.4	-0.5	-0.6	-1.2
Alcohol intake frequency.	0.3	0.7	3.6	1.9	-0.3	-0.5	0.1	0.4	-0.4
Comparative height size at age 10	1.8	9.7	20.0	3.6	2.9	2.7	1.7	-2.6	-4.5
Number of full sisters	1.2	1.5	2.7	0.3	1.4	1.4	0.6	-1.3	-1.6
Suffer from ‘nerves’	1.4	2.2	6.6	-0.8	-1.5	-1.4	-0.3	1.3	2.6
Overall health rating	0.1	0.2	1.1	1.0	0.0	-0.1	-0.2	0.1	-0.3
Chest pain or discomfort	1.0	1.4	2.4	-0.1	-1.4	-1.4	0.5	1.6	1.3
Had major operations	0.6	0.8	3.3	1.8	-0.5	-0.6	-0.4	0.6	-0.1
Age at last live birth	0.9	1.4	2.3	-1.0	1.2	1.3	0.1	-1.5	-1.3
Family relationship satisfaction	0.3	0.3	0.8	0.9	0.5	0.6	0.1	-0.7	-0.2
Leg pain on walking	0.8	0.9	4.2	-2.0	0.1	0.1	0.7	-0.1	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	1.5	0.3	0.3	0.8	-0.2	-0.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	6.1	2.5	-0.9	-0.9	0.2	1.0	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	-0.3	-1.0	-1.0	-0.2	0.9	0.6
Medication: Aspirin	0.9	1.2	2.5	-1.6	0.9	0.8	-0.7	-0.9	-1.4
Supplements: Vitamin C	0.8	1.0	2.1	-0.4	1.1	1.1	-0.2	-1.1	-1.4
Knee pain experienced in last month	1.3	2.1	3.3	0.1	-1.8	-1.8	0.6	1.7	1.6
Hypertension (Self-reported)	0.2	0.4	1.4	-1.2	0.3	0.2	0.1	-0.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	12.1	-0.7	0.3	0.1	-3.5	0.0	-0.6
Illnesses of father: Heart disease	0.5	0.6	1.1	0.1	0.9	1.0	0.2	-1.1	-0.8
Illnesses of siblings: Diabetes	0.6	0.8	1.7	1.3	0.9	0.8	0.2	-0.8	-0.8
Smoking status: Previous	0.8	1.2	2.0	1.0	1.2	1.2	0.3	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	12.7	3.6	1.2	1.1	0.9	-1.1	-1.1
Whole body fat-free mass	1.6	9.2	19.8	2.2	3.3	2.9	-2.0	-2.7	-4.5
Leg fat-free mass (right)	1.2	6.5	14.1	1.5	2.8	2.4	-2.0	-2.3	-3.8
Arm fat percentage (left)	0.1	0.6	1.7	-0.9	-0.5	-0.6	-1.3	0.5	-0.6
Average weekly red wine intake	0.3	0.5	1.4	1.1	0.1	0.1	1.2	-0.3	0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.3	-1.1	-0.6	-0.6	-1.3	0.6	1.5
Mood swings	0.1	0.1	0.7	-0.1	0.2	0.1	-0.8	-0.1	-0.1
Loneliness, isolation	1.4	1.9	3.0	-1.7	1.5	1.6	0.5	-1.6	-0.8
Long-standing illness, disability or infirmity	1.0	1.6	2.5	-0.7	1.3	1.3	1.0	-1.4	-1.6
Ever had bowel cancer screening	0.1	0.2	0.8	0.4	0.2	0.1	-0.0	-0.0	-0.9
Diabetes diagnosed by doctor	0.5	0.9	2.3	-0.4	0.9	0.9	-0.6	-0.8	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.5	0.3	1.0	0.9	0.7	-0.9	-1.2
Friendships satisfaction	0.3	0.4	0.8	0.9	-0.5	-0.6	0.6	0.5	0.2
Qualifications: nursing, teaching	1.2	1.8	3.1	0.5	-1.7	-1.6	-0.1	1.5	1.8
Commuting to job workplace: Walk	1.0	1.1	2.6	-1.6	-0.9	-0.9	0.5	0.8	1.1
Eye problems/disorders: Cataract	1.2	1.4	2.4	-0.9	1.1	1.2	1.3	-1.1	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.8	-0.8	1.1	1.1	0.8	-1.0	-1.3
Medication for cholesterol	0.7	1.1	3.4	1.8	0.8	0.8	-0.6	-0.9	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.2	-0.3	0.4	0.5	-1.1	-0.6	-0.0
Back pain experienced in last month	0.6	0.9	1.4	0.1	-1.1	-1.2	0.2	1.1	1.0
Mineral and other dietary supplements	0.8	1.1	2.3	-1.2	-0.8	-0.7	1.2	0.6	1.5
Breast cancer (self-reported)	0.4	0.5	0.9	-1.0	0.7	0.7	-0.0	-0.8	-0.4
Asthma (self-reported)	1.7	3.4	8.3	-0.7	1.7	1.7	2.9	-1.6	-1.9
Osteoporosis (self-reported)	0.2	0.2	1.3	-0.0	0.1	0.1	1.1	-0.0	0.2
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.3	-0.3	-0.2	0.0	0.1	-0.2
Medication: Aspirin	0.8	1.1	3.2	-1.8	0.6	0.6	-0.7	-0.6	-1.3
Medication: Gliclazide	0.6	0.6	1.3	0.2	1.1	1.1	-0.2	-1.1	-0.3
Illnesses of father: None of the above (group 1)	2.0	2.4	5.0	-2.2	1.4	1.3	-0.5	-1.2	-2.0
Smoking status: Current	0.5	0.8	1.2	1.1	1.1	0.9	-0.2	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.7	0.1	0.2	0.2	1.6	-0.3	0.2
Whole body water mass	1.6	8.9	19.0	2.2	3.2	2.8	-2.2	-2.6	-4.4
Leg predicted mass (right)	1.2	6.5	14.2	1.6	2.7	2.4	-1.9	-2.3	-3.8
Arm fat mass (left)	0.3	1.3	3.5	0.6	0.5	0.3	-1.9	-0.3	-1.8
Number of self-reported non-cancer illnesses	3.5	6.1	8.0	-1.4	2.8	2.8	1.8	-2.8	-2.8
Average weekly champagne plus white wine intake	2.1	3.0	4.7	-0.1	1.9	2.0	1.1	-2.0	-2.2
Miserableness	0.3	0.4	1.5	-0.7	-0.4	-0.5	-1.2	0.6	0.0
Guilty feelings	0.1	0.1	0.4	0.2	0.1	0.2	-0.2	-0.1	0.7
Wears glasses or contact lenses	1.5	1.7	3.2	1.2	1.4	1.2	-1.1	-1.2	-1.8
Ever taken oral contraceptive pill	0.6	0.7	2.1	1.4	-0.6	-0.7	-0.8	0.7	0.3
Hearing aid user	0.3	0.4	0.6	0.6	0.7	0.6	-0.8	-0.5	-0.3
Mother’s age at death	0.2	0.2	0.7	0.9	-0.2	-0.2	-0.2	0.4	0.3
Financial situation satisfaction	0.5	0.6	3.0	-0.5	0.3	0.3	1.7	-0.3	0.2
Tinnitus: Yes, now most or all of the time	4.3	5.1	7.8	0.2	2.8	2.8	-1.6	-2.6	-2.4
Commuting to job workplace: Public transport	1.5	1.7	3.4	-0.3	1.6	1.5	-0.2	-1.5	-1.9
Eye problems/disorders: Glaucoma	0.3	0.4	2.1	1.4	-0.1	-0.1	-0.2	0.1	0.6
Medication: Blood pressure	0.4	0.7	2.5	-1.6	-0.7	-0.7	0.5	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	0.9	0.4	0.3	1.0	-0.4	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.1	0.4	0.7	0.6	-1.5	-0.4	-1.3
High cholesterol (Self-reported)	2.3	4.1	6.4	-0.9	2.5	2.5	-0.0	-2.5	-2.3
Medication: Bendroflumethiazide	0.4	0.6	0.9	-0.7	0.9	0.8	0.5	-0.8	-0.6
Medication: Paracetamol	0.7	1.2	1.5	-1.2	-1.1	-1.0	1.0	1.0	1.1
Medication: Lisinopril	1.0	1.3	2.2	0.8	1.4	1.5	0.7	-1.4	-1.0
Medication: Atorvastatin	1.4	1.8	5.2	-1.1	1.2	1.1	-2.3	-1.2	-0.7
Illnesses of father: High blood pressure	4.2	5.3	12.2	-0.2	-2.6	-2.4	-0.4	2.5	3.5
Alcohol drinker status: Never	0.6	0.7	2.1	-0.9	0.5	0.7	1.4	-0.5	-0.5
Ever smoked	0.1	0.2	0.3	0.3	0.5	0.5	-0.5	-0.3	-0.4
Basal metabolic rate	1.4	7.9	17.9	2.1	3.0	2.6	-2.0	-2.4	-4.2
Leg fat percentage (left)	0.2	0.6	2.5	-0.0	-0.3	-0.4	-1.6	0.4	-0.8
Arm fat-free mass (left)	1.7	8.5	19.0	2.1	3.1	2.6	-2.3	-2.4	-4.4
Number of operations (self-reported)	0.6	0.9	2.5	0.1	1.0	0.9	0.4	-0.9	-1.6
Average weekly beer plus cider intake	0.1	0.2	0.9	-0.0	-0.3	-0.4	-1.0	0.3	0.0
Irritability	0.6	1.0	3.1	-1.8	-0.5	-0.5	-1.2	0.4	0.9
Risk taking	0.8	1.2	2.2	-0.0	1.4	1.5	-0.4	-1.4	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.7	0.0	0.5	0.5	-1.3	-0.5	-0.5
Fractured/broken bones in last 5 years	0.2	0.2	1.2	-0.3	0.1	0.2	1.1	-0.1	0.1
Age started oral contraceptive pill	0.7	0.9	1.7	-0.1	-1.3	-1.2	0.7	1.2	0.5
Diastolic blood pressure, automated reading	0.4	1.1	2.0	-0.3	-1.1	-1.2	0.2	1.4	1.3
Ever depressed for a whole week	2.3	2.8	4.4	-0.7	2.0	1.9	0.9	-1.9	-2.1
Unable to work because of sickness or disability	0.4	0.5	2.0	1.4	0.0	-0.2	-0.5	0.2	-1.0
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.7	0.2	0.3	-0.7	-0.3	0.2
Myopia	2.5	3.7	5.2	-1.6	2.3	2.3	-0.7	-2.3	-1.8
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.0	0.8	-0.7	-0.7	-0.5	0.7	1.4
Cholesterol lowering medication	0.7	1.0	4.8	-2.2	0.4	0.5	-0.4	-0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.5	-1.6	0.3	0.4	0.6	-0.3	-0.1
Pain experienced in last month	1.6	2.7	4.3	-0.3	1.9	2.0	1.0	-1.9	-2.1
Supplements: Calcium	4.4	4.8	7.1	1.2	2.5	2.6	0.7	-2.7	-2.6
Basal cell carcinoma (self-reported)	0.5	0.7	1.0	0.4	1.0	0.9	-0.2	-0.9	-1.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	0.2	0.3	0.3	0.7	-0.2	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.8	-2.0	-0.7	-0.7	-0.1	0.7	0.6
Heart disease (siblings)	0.6	0.7	1.2	-0.8	0.9	0.9	0.3	-0.8	-1.1
Alcohol drinker status: Previous	0.4	0.5	1.6	1.3	-0.4	-0.6	0.6	0.5	-0.3
Pack years of smoking	0.5	0.7	2.3	1.1	-0.3	-0.4	-1.5	0.5	0.5
Impedance of whole body	0.5	2.6	12.2	0.7	-1.0	-0.6	3.5	0.5	1.2
Leg fat mass (left)	0.5	1.9	5.3	0.6	0.8	0.5	-2.1	-0.5	-2.3
Arm predicted mass (left)	1.6	8.2	18.1	2.4	2.9	2.4	-2.4	-2.2	-4.3