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chr1:25,475,418-28,515,292

Best TWAS P=2.39e-24 · Best GWAS P=1.88e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Cortex	CNKSR1	0.46	0.23	enet	33	0.31	3.5e-09	-2.21	6.5	5.9e-11	-0.14	0.83	0.02	FALSE
2	GTEx	Cells Transformed fibroblasts	RP1-125I3.2	0.06	0.04	enet	19	0.03	3.3e-03	7.35	-7.6	2.3e-14	0.20	0.08	0.48	FALSE
3	GTEx	Colon Transverse	CNKSR1	0.14	0.00	enet	21	0.00	2.0e-01	-3.87	5.1	2.8e-07	0.03	0.12	0.11	FALSE
4	GTEx	Esophagus Mucosa	DHDDS	0.11	0.06	lasso	4	0.04	6.6e-04	-10.64	-9.7	4.5e-22	0.91	0.00	1.00	TRUE
5	GTEx	Esophagus Mucosa	PDIK1L	0.10	0.09	lasso	6	0.09	8.8e-07	9.48	-9.4	6.8e-21	0.17	0.96	0.01	FALSE
6	GTEx	Muscle Skeletal	PIGV	0.07	0.01	enet	12	0.02	2.1e-03	3.72	-6.0	2.5e-09	0.13	0.49	0.03	TRUE
7	GTEx	Nerve Tibial	NUDC	0.12	0.00	lasso	6	0.01	1.2e-01	6.74	6.4	1.6e-10	-0.31	0.02	0.48	TRUE
8	GTEx	Nerve Tibial	PDIK1L	0.09	0.01	enet	10	0.03	2.2e-03	7.97	-8.9	5.7e-19	0.21	0.72	0.06	FALSE
9	GTEx	Pancreas	CNKSR1	0.20	0.03	enet	20	0.04	7.3e-03	7.71	-7.7	1.8e-14	0.34	0.09	0.34	FALSE
10	GTEx	Pituitary	CNKSR1	0.38	0.16	lasso	7	0.15	1.4e-04	4.55	-6.1	9.5e-10	0.19	0.33	0.04	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	CNKSR1	0.15	0.10	lasso	7	0.09	1.0e-05	4.55	-6.8	1.5e-11	0.17	0.93	0.00	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	PDIK1L	0.22	0.05	enet	37	0.11	8.3e-07	9.48	-7.3	3.2e-13	0.22	0.98	0.01	TRUE
13	GTEx	Skin Sun Exposed Lower leg	CNKSR1	0.10	0.04	enet	21	0.04	2.2e-04	4.68	-5.5	3.1e-08	0.29	0.38	0.20	FALSE
14	GTEx	Skin Sun Exposed Lower leg	PDIK1L	0.14	0.05	enet	23	0.12	3.1e-10	9.48	-7.2	6.9e-13	0.19	0.99	0.01	FALSE
15	GTEx	Spleen	PIGV	0.16	0.13	lasso	13	0.16	6.6e-05	5.44	-5.7	1.2e-08	0.10	0.31	0.05	FALSE
16	GTEx	Testis	RP1-317E23.7	0.59	0.52	enet	20	0.58	4.6e-31	4.92	-5.2	2.0e-07	0.08	1.00	0.00	TRUE
17	GTEx	Thyroid	DHDDS	0.14	0.08	enet	22	0.07	5.8e-06	4.75	-5.9	3.2e-09	0.41	0.68	0.02	FALSE
18	GTEx	Thyroid	CNKSR1	0.10	0.04	lasso	7	0.03	2.1e-03	8.31	-9.2	2.4e-20	0.20	0.78	0.08	FALSE
19	GTEx	Whole Blood	CEP85	0.07	0.01	enet	17	0.02	1.3e-02	-2.30	-7.4	1.4e-13	0.17	0.23	0.18	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	WASF2	0.08	0.04	blup	261	0.04	1.4e-05	-4.20	-5.2	2.6e-07	0.03	0.16	0.79	TRUE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM63	0.03	0.02	blup	33	0.02	4.6e-03	9.44	8.9	5.4e-19	-0.15	0.01	0.90	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXTL1	0.02	0.02	blup	46	0.02	1.5e-05	4.67	-5.2	2.0e-07	0.12	0.49	0.43	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRRP1	0.03	0.02	enet	7	0.01	3.9e-04	-3.33	-5.8	7.3e-09	0.13	0.11	0.79	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDIK1L	0.02	0.01	blup	37	0.02	6.1e-05	9.53	-7.9	3.9e-15	0.14	0.01	0.95	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM63	0.15	0.16	lasso	2	0.16	2.3e-32	9.44	9.5	2.4e-21	-0.15	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM63	0.14	0.15	lasso	1	0.14	2.2e-07	9.43	9.4	4.0e-21	-0.14	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM63	0.08	0.10	lasso	4	0.10	3.7e-06	9.44	9.3	1.7e-20	-0.17	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRRP1	0.11	0.02	blup	52	0.03	8.8e-05	-3.36	5.8	6.2e-09	-0.04	0.02	0.29	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDIK1L	0.02	0.02	blup	37	0.02	2.8e-03	9.53	-9.8	8.7e-23	0.14	0.01	0.87	TRUE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC30A2	0.03	0.02	lasso	3	0.01	1.1e-02	5.54	-7.3	3.4e-13	0.12	0.02	0.86	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM63	0.11	0.11	enet	4	0.12	9.0e-14	9.44	9.0	3.3e-19	-0.15	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDIK1L	0.03	0.01	blup	37	0.02	2.6e-03	8.33	-10.2	2.4e-24	0.11	0.01	0.60	TRUE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM63	0.29	0.33	enet	20	0.33	2.5e-38	9.44	10.1	4.2e-24	-0.15	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM63	0.14	0.20	enet	7	0.21	9.4e-24	9.08	9.1	9.5e-20	-0.17	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CNKSR1	0.11	0.03	blup	57	0.05	3.5e-06	8.31	-7.2	7.8e-13	0.21	0.14	0.56	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PDIK1L	0.02	0.00	blup	37	0.02	1.2e-03	6.16	-7.8	6.5e-15	0.17	0.02	0.76	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM63	0.16	0.11	lasso	1	0.10	2.0e-11	9.44	9.4	3.7e-21	-0.15	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM63	0.14	0.18	lasso	7	0.15	3.0e-10	9.12	8.8	1.4e-18	-0.16	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS6KA1	0.11	0.05	lasso	6	0.07	8.0e-04	-8.43	7.9	3.2e-15	-0.61	0.01	0.87	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRIM63	0.09	0.05	lasso	1	0.04	1.2e-02	6.16	6.2	7.3e-10	-0.08	0.02	0.41	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	DHDDS	0.04	0.00	blup	50	0.02	5.7e-03	2.81	-5.3	1.3e-07	0.47	0.02	0.14	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDIK1L	0.03	0.03	blup	37	0.02	7.0e-03	-0.36	-5.2	2.5e-07	0.16	0.03	0.28	TRUE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	SH3BGRL3	0.05	0.03	lasso	2	0.03	9.3e-04	7.35	8.4	6.0e-17	-0.16	0.00	0.94	FALSE
44	The Cancer Genome Atlas	Rectum Adenocarcinoma	EXTL1	0.14	0.03	blup	46	0.05	2.2e-02	4.89	-6.6	3.4e-11	0.14	0.02	0.44	FALSE
45	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM63	0.28	0.22	lasso	3	0.20	1.7e-05	5.54	7.2	7.4e-13	-0.11	0.02	0.89	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM63	0.18	0.26	enet	7	0.26	3.0e-25	9.08	9.2	3.6e-20	-0.15	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM63	0.19	0.07	blup	33	0.14	1.3e-04	9.44	9.0	3.4e-19	-0.15	0.01	0.99	FALSE