[Hub]/) : Traits : Sitting height :

chr1:25,475,418-28,515,292

Best TWAS P=2.39e-24 · Best GWAS P=1.88e-26 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cortex CNKSR1 0.46 0.23 enet 33 0.31 3.5e-09 -2.21 6.5 5.9e-11 -0.14 0.83 0.02 FALSE
2 GTEx Cells Transformed fibroblasts RP1-125I3.2 0.06 0.04 enet 19 0.03 3.3e-03 7.35 -7.6 2.3e-14 0.20 0.08 0.48 FALSE
3 GTEx Colon Transverse CNKSR1 0.14 0.00 enet 21 0.00 2.0e-01 -3.87 5.1 2.8e-07 0.03 0.12 0.11 FALSE
4 GTEx Esophagus Mucosa DHDDS 0.11 0.06 lasso 4 0.04 6.6e-04 -10.64 -9.7 4.5e-22 0.91 0.00 1.00 TRUE
5 GTEx Esophagus Mucosa PDIK1L 0.10 0.09 lasso 6 0.09 8.8e-07 9.48 -9.4 6.8e-21 0.17 0.96 0.01 FALSE
6 GTEx Muscle Skeletal PIGV 0.07 0.01 enet 12 0.02 2.1e-03 3.72 -6.0 2.5e-09 0.13 0.49 0.03 TRUE
7 GTEx Nerve Tibial NUDC 0.12 0.00 lasso 6 0.01 1.2e-01 6.74 6.4 1.6e-10 -0.31 0.02 0.48 TRUE
8 GTEx Nerve Tibial PDIK1L 0.09 0.01 enet 10 0.03 2.2e-03 7.97 -8.9 5.7e-19 0.21 0.72 0.06 FALSE
9 GTEx Pancreas CNKSR1 0.20 0.03 enet 20 0.04 7.3e-03 7.71 -7.7 1.8e-14 0.34 0.09 0.34 FALSE
10 GTEx Pituitary CNKSR1 0.38 0.16 lasso 7 0.15 1.4e-04 4.55 -6.1 9.5e-10 0.19 0.33 0.04 FALSE
11 GTEx Skin Not Sun Exposed Suprapubic CNKSR1 0.15 0.10 lasso 7 0.09 1.0e-05 4.55 -6.8 1.5e-11 0.17 0.93 0.00 FALSE
12 GTEx Skin Not Sun Exposed Suprapubic PDIK1L 0.22 0.05 enet 37 0.11 8.3e-07 9.48 -7.3 3.2e-13 0.22 0.98 0.01 TRUE
13 GTEx Skin Sun Exposed Lower leg CNKSR1 0.10 0.04 enet 21 0.04 2.2e-04 4.68 -5.5 3.1e-08 0.29 0.38 0.20 FALSE
14 GTEx Skin Sun Exposed Lower leg PDIK1L 0.14 0.05 enet 23 0.12 3.1e-10 9.48 -7.2 6.9e-13 0.19 0.99 0.01 FALSE
15 GTEx Spleen PIGV 0.16 0.13 lasso 13 0.16 6.6e-05 5.44 -5.7 1.2e-08 0.10 0.31 0.05 FALSE
16 GTEx Testis RP1-317E23.7 0.59 0.52 enet 20 0.58 4.6e-31 4.92 -5.2 2.0e-07 0.08 1.00 0.00 TRUE
17 GTEx Thyroid DHDDS 0.14 0.08 enet 22 0.07 5.8e-06 4.75 -5.9 3.2e-09 0.41 0.68 0.02 FALSE
18 GTEx Thyroid CNKSR1 0.10 0.04 lasso 7 0.03 2.1e-03 8.31 -9.2 2.4e-20 0.20 0.78 0.08 FALSE
19 GTEx Whole Blood CEP85 0.07 0.01 enet 17 0.02 1.3e-02 -2.30 -7.4 1.4e-13 0.17 0.23 0.18 TRUE
20 ROSMAP Brain Pre-frontal Cortex WASF2 0.08 0.04 blup 261 0.04 1.4e-05 -4.20 -5.2 2.6e-07 0.03 0.16 0.79 TRUE
21 The Cancer Genome Atlas Bladder Urothelial Carcinoma TRIM63 0.03 0.02 blup 33 0.02 4.6e-03 9.44 8.9 5.4e-19 -0.15 0.01 0.90 FALSE
22 The Cancer Genome Atlas Breast Invasive Carcinoma EXTL1 0.02 0.02 blup 46 0.02 1.5e-05 4.67 -5.2 2.0e-07 0.12 0.49 0.43 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma GRRP1 0.03 0.02 enet 7 0.01 3.9e-04 -3.33 -5.8 7.3e-09 0.13 0.11 0.79 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma PDIK1L 0.02 0.01 blup 37 0.02 6.1e-05 9.53 -7.9 3.9e-15 0.14 0.01 0.95 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma TRIM63 0.15 0.16 lasso 2 0.16 2.3e-32 9.44 9.5 2.4e-21 -0.15 0.00 1.00 FALSE
26 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TRIM63 0.14 0.15 lasso 1 0.14 2.2e-07 9.43 9.4 4.0e-21 -0.14 0.00 1.00 FALSE
27 The Cancer Genome Atlas Colon Adenocarcinoma TRIM63 0.08 0.10 lasso 4 0.10 3.7e-06 9.44 9.3 1.7e-20 -0.17 0.01 0.99 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GRRP1 0.11 0.02 blup 52 0.03 8.8e-05 -3.36 5.8 6.2e-09 -0.04 0.02 0.29 FALSE
29 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDIK1L 0.02 0.02 blup 37 0.02 2.8e-03 9.53 -9.8 8.7e-23 0.14 0.01 0.87 TRUE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC30A2 0.03 0.02 lasso 3 0.01 1.1e-02 5.54 -7.3 3.4e-13 0.12 0.02 0.86 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TRIM63 0.11 0.11 enet 4 0.12 9.0e-14 9.44 9.0 3.3e-19 -0.15 0.00 1.00 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma PDIK1L 0.03 0.01 blup 37 0.02 2.6e-03 8.33 -10.2 2.4e-24 0.11 0.01 0.60 TRUE
33 The Cancer Genome Atlas Brain Lower Grade Glioma TRIM63 0.29 0.33 enet 20 0.33 2.5e-38 9.44 10.1 4.2e-24 -0.15 0.00 1.00 FALSE
34 The Cancer Genome Atlas Lung Adenocarcinoma TRIM63 0.14 0.20 enet 7 0.21 9.4e-24 9.08 9.1 9.5e-20 -0.17 0.01 0.99 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CNKSR1 0.11 0.03 blup 57 0.05 3.5e-06 8.31 -7.2 7.8e-13 0.21 0.14 0.56 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PDIK1L 0.02 0.00 blup 37 0.02 1.2e-03 6.16 -7.8 6.5e-15 0.17 0.02 0.76 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TRIM63 0.16 0.11 lasso 1 0.10 2.0e-11 9.44 9.4 3.7e-21 -0.15 0.00 1.00 FALSE
38 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TRIM63 0.14 0.18 lasso 7 0.15 3.0e-10 9.12 8.8 1.4e-18 -0.16 0.04 0.96 FALSE
39 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RPS6KA1 0.11 0.05 lasso 6 0.07 8.0e-04 -8.43 7.9 3.2e-15 -0.61 0.01 0.87 FALSE
40 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TRIM63 0.09 0.05 lasso 1 0.04 1.2e-02 6.16 6.2 7.3e-10 -0.08 0.02 0.41 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma DHDDS 0.04 0.00 blup 50 0.02 5.7e-03 2.81 -5.3 1.3e-07 0.47 0.02 0.14 FALSE
42 The Cancer Genome Atlas Prostate Adenocarcinoma PDIK1L 0.03 0.03 blup 37 0.02 7.0e-03 -0.36 -5.2 2.5e-07 0.16 0.03 0.28 TRUE
43 The Cancer Genome Atlas Prostate Adenocarcinoma SH3BGRL3 0.05 0.03 lasso 2 0.03 9.3e-04 7.35 8.4 6.0e-17 -0.16 0.00 0.94 FALSE
44 The Cancer Genome Atlas Rectum Adenocarcinoma EXTL1 0.14 0.03 blup 46 0.05 2.2e-02 4.89 -6.6 3.4e-11 0.14 0.02 0.44 FALSE
45 The Cancer Genome Atlas Rectum Adenocarcinoma TRIM63 0.28 0.22 lasso 3 0.20 1.7e-05 5.54 7.2 7.4e-13 -0.11 0.02 0.89 FALSE
46 The Cancer Genome Atlas Thyroid Carcinoma TRIM63 0.18 0.26 enet 7 0.26 3.0e-25 9.08 9.2 3.6e-20 -0.15 0.01 0.99 FALSE
47 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TRIM63 0.19 0.07 blup 33 0.14 1.3e-04 9.44 9.0 3.4e-19 -0.15 0.01 0.99 FALSE