Hub : Genes

TXLNA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.038 0.0160 0.00087 0.036 0.024 0.014 0.029 0.024 3.0e-05 0.00054 0.00630 0.00018 0.00050
2 GTEx Brain Cerebellum 0.144 0.0590 0.00540 0.136 NA 0.097 NA 0.123 8.1e-05 NA 0.00083 NA 0.00017
3 GTEx Brain Frontal Cortex BA9 0.223 0.0917 0.00760 -0.011 NA -0.001 NA -0.011 9.1e-01 NA 0.33000 NA 0.92000
4 GTEx Nerve Tibial 0.095 0.0502 0.00870 -0.004 NA -0.003 NA -0.003 8.5e-01 NA 0.68000 NA 0.70000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.3 2.9 1.4 1.7 0.3 0.4
Bipolar Disorder or Schizophrenia 1.0 2.5 4.0 2.0 1.5 1.8 0.6
Depressed Affect (Nagel 2018) 0.5 1.0 2.9 -1.7 -0.2 0.5 0.9
Depression (Nagel 2018) 1.6 2.4 4.3 -2.1 -1.9 -1.2 -0.8
Intelligence (Savage-Jansen 2018) 0.6 1.9 3.8 -1.5 -1.0 -0.6 -1.9
Neuroticism (Nagel 2018) 0.2 0.4 0.8 -0.7 0.9 0.3 0.6
Schizophrenia (2018) 0.8 1.8 4.5 1.4 0.6 2.1 0.5
Schizophrenia vs Biploar Disorder 0.6 0.7 1.1 0.7 -0.7 1.0 0.9
Worry (Nagel 2018) 0.6 1.2 3.7 0.6 1.9 -0.6 0.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.7 0.6 -0.3 0.0 -0.8
Alzheimer’s Disease (in father) 0.4 0.5 0.9 0.7 0.4 -1.0 0.5
Alzheimer’s Disease (including proxy) 0.3 0.4 1.1 0.6 0.1 -0.4 -1.1
Crohns Disease (2017) 0.1 0.3 0.6 0.8 -0.1 -0.6 -0.3
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 0.4 -0.2 -0.4 -0.1
Ulcerative Colitis (UC) 0.0 0.0 0.1 0.1 0.1 -0.0 0.3
Major Depression (MDD) 0.6 0.7 2.0 -0.2 0.0 1.4 -0.9
Reaction Time 0.7 1.2 1.8 1.3 0.9 0.8 1.3
Verbal and Numeric Reasoning (VNR) 1.0 2.4 3.9 -1.8 -2.0 -0.4 -1.4
Breast Cancer 1.4 3.4 4.3 -1.7 -1.9 2.1 -1.7
Ovarian Cancer 0.7 1.0 1.9 0.3 -1.4 -0.4 1.3
Prostate Cancer 2.5 3.5 4.8 0.9 1.9 2.2 2.2
Age at First Birth 0.9 1.3 2.0 -0.1 -1.3 1.3 1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.6 -1.2 -0.8 1.3 -0.7
Coronary Artery Disease (CAD) 0.7 0.8 1.7 -0.7 0.1 -1.3 -1.1
Crohns Disease (2012) 0.8 1.3 4.5 -0.4 -0.4 0.6 -2.1
Mean Putamen Volume 0.1 0.2 0.3 0.2 0.4 0.4 0.5
Fasting Glucose 2.4 2.9 7.2 -1.6 -1.3 -0.5 -2.7
HbA1C 0.7 0.8 2.2 -1.5 0.4 0.0 -0.9
HDL Cholesterol 0.2 0.3 0.8 0.9 -0.5 -0.5 0.4
LDL Cholesterol 0.5 0.8 1.6 0.6 1.3 -0.9 0.5
Lupus 0.7 1.1 3.1 -1.0 -1.8 0.1 -0.4
Neuroticism (2016) 0.2 0.3 0.7 -0.8 -0.2 0.1 0.7
Primary Biliary Cirrhosis 0.3 0.5 1.4 -0.5 0.3 0.4 -1.2
Rheumatoid Arthritis 1.2 1.7 3.2 -1.6 -0.2 -1.1 -1.8
Schizophrenia (2014) 1.5 3.3 5.7 2.3 0.8 2.4 1.4
Triglycerides 0.2 0.3 0.6 -0.8 0.5 -0.4 -0.4
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 -0.1 0.9 0.0 0.8
Ulcerative Colitis 0.2 0.3 0.8 -0.6 -0.9 0.2 -0.4
Blood Eosinophil Count 0.3 2.4 5.6 -2.4 -1.6 -1.1 -0.4
Blood Platelet Count 0.1 0.8 1.7 -1.3 -0.2 -1.2 -0.4
Blood Red Count 0.1 1.4 3.0 -1.5 -0.4 -0.3 -1.7
Blood White Count 1.2 9.1 19.9 -2.9 -1.7 -2.4 -4.5
Heel T-Score 0.5 3.9 11.6 -1.2 -3.4 0.3 1.6
BMI 1.9 11.2 16.4 -4.0 -3.9 2.9 -2.3
Height 1.3 25.5 47.6 -6.5 -2.6 2.2 -6.9
Waist Hip Ratio (WHR) 0.2 0.9 2.7 -0.5 1.6 0.9 -0.2
Systolic Blood Pressure 0.1 0.4 1.1 0.6 -0.5 -0.0 -1.1
Smoking Status 1.3 3.1 5.8 -2.2 -0.3 -1.3 -2.4
Allergy or Eczema 0.3 0.8 2.0 -0.9 -0.5 0.2 -1.4
Cardiovascular Disease 0.9 3.1 6.3 -2.5 -0.2 1.5 -1.9
Hypothyroidism (self reported) 0.3 0.6 1.3 -1.0 -0.3 0.1 -1.1
Respiratory disease 1.2 2.7 4.3 -1.8 -2.1 1.0 -1.6
Type 2 Diabetes (T2D) (2018) 2.0 3.7 6.6 -1.7 -2.6 1.8 -1.4
Lung FEV1/FVC ratio 0.9 4.6 13.1 -0.6 -2.2 3.6 0.2
Lung FVC 0.1 0.7 2.1 0.7 -0.1 0.2 1.5
Neuroticism 0.1 0.2 0.5 -0.2 0.7 0.3 -0.5
Chronotype (morning person) 0.3 0.8 2.2 1.5 0.2 -0.9 0.4
Hair Pigment 0.0 0.7 2.7 -0.3 -0.2 0.2 1.6
Tanning 0.1 1.3 2.6 1.5 -0.5 1.6 0.0
Hand grip strength (left) 1.1 2.9 5.9 -1.8 -2.4 1.4 -0.7
Number of treatments/medications taken 1.4 2.6 6.2 -2.5 -0.3 0.9 -1.8
Average weekly spirits intake 0.1 0.1 0.4 0.1 0.0 -0.7 0.3
Sensitivity / hurt feelings 0.4 0.6 1.0 -0.7 0.2 -1.0 -1.0
Frequency of depressed mood in last 2 weeks 0.4 0.6 0.9 -0.6 -1.0 -0.7 0.7
Hearing difficulty/problems: Yes 1.3 2.0 3.1 -1.8 -1.4 0.7 -1.6
Relative age of first facial hair 0.6 1.2 1.7 -1.3 -1.1 0.5 -1.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.7 0.0 -0.0 -0.2 -1.3
Ever used hormone-replacement therapy (HRT) 1.2 1.5 4.5 -0.6 -0.9 2.1 0.6
Ever had hysterectomy (womb removed) 0.3 0.4 0.7 -0.8 -0.2 0.1 -0.8
Systolic blood pressure, automated reading 0.3 0.8 2.2 1.5 -0.4 0.8 0.4
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 5.9 -0.1 -2.4 1.3 -1.0
Angina 0.6 0.9 1.3 -0.5 -1.1 0.8 -1.1
Medication for hormone replacement therapy 0.6 0.7 1.4 1.2 -0.5 0.4 1.0
Vitamin and mineral supplements 0.5 0.7 2.1 0.3 -1.4 0.7 0.2
Supplements: Zinc 0.4 0.4 0.6 -0.5 0.6 -0.7 -0.8
Medication: Co-codamol 1.3 1.5 4.1 -2.0 -0.9 -0.3 -1.1
Medication: Metformin 1.5 2.1 2.8 -1.7 -1.6 0.8 -1.5
Diabetes (father) 1.1 1.4 3.7 0.8 1.9 0.8 -0.7
Diabetes (mother) 1.3 1.7 4.5 -1.5 0.2 -0.1 -2.1
Severe depression (siblings) 0.8 0.9 2.5 1.6 0.9 -0.4 -0.4
Pack years adult smoking proportion 0.5 0.7 2.0 0.5 1.4 -0.1 -0.7
Impedance of leg (right) 0.9 4.4 9.7 0.8 2.6 -3.1 0.6
Leg fat-free mass (left) 2.6 13.7 22.8 -4.8 -3.0 3.1 -3.6
Trunk fat percentage 0.9 3.6 7.6 -2.8 -1.9 1.7 -0.8
Hand grip strength (right) 0.5 1.4 2.3 -1.0 -1.5 1.0 -1.1
Townsend deprivation index at recruitment 0.4 0.6 1.4 0.0 -1.1 -1.2 -0.0
Current tobacco smoking 0.9 1.5 2.8 -0.9 1.4 -0.7 -1.7
Average weekly fortified wine intake 0.3 0.4 0.9 -0.4 -1.0 0.7 0.1
Maternal smoking around birth 1.1 1.5 3.8 -0.7 0.5 -1.3 -1.9
Fed-up feelings 0.2 0.4 1.2 -1.1 -0.3 -0.6 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 -1.1 -1.3 -0.6 -0.0
Relative age voice broke 2.2 3.4 4.8 -2.1 -1.7 -1.1 -2.2
Taking other prescription medications 2.4 3.7 7.3 -2.7 -1.6 0.7 -2.0
Age when periods started (menarche) 0.8 1.9 3.5 1.9 1.3 1.5 0.4
Bilateral oophorectomy (both ovaries removed) 1.9 2.1 3.2 -1.7 -1.8 -0.8 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.0 -1.5 -1.7 1.2 -0.8
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 5.5 -1.4 -2.3 -0.1 -0.8
Qualifications: CSEs or equivalent 0.7 1.0 2.1 1.3 1.4 0.1 0.4
Serious illness, injury or assault to yourself 0.8 0.9 2.0 0.6 -1.2 1.4 -0.0
High blood pressure 1.6 4.5 10.5 -1.8 -0.7 3.2 -2.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.9 -1.3 -0.5 -0.7 -1.4
Multivitamins +/- minerals 0.0 0.1 0.1 -0.1 0.4 -0.2 0.0
Stomach or abdominal pain in last month 0.3 0.3 0.7 -0.8 -0.7 -0.4 0.0
Supplements: Glucosamine 0.3 0.4 1.1 -1.0 0.1 -0.3 -0.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.5 -0.7 0.5 -0.4 -0.5
Medication: Atenolol 1.2 1.6 3.7 0.8 -1.1 1.9 0.8
Medication: Levothyroxine sodium 0.5 0.9 2.0 -1.2 -0.2 -1.4 -0.5
Sitting height 2.4 16.9 33.4 -5.8 -1.7 0.2 -5.6
Chronic bronchitis/emphysema (father) 1.6 1.8 4.8 1.4 2.2 0.3 0.7
High blood pressure (mother) 0.8 1.2 2.0 1.1 -1.4 -0.1 1.1
Body mass index (BMI) 1.6 6.7 11.3 -2.3 -3.4 3.2 -0.3
Impedance of leg (left) 0.9 4.2 9.0 0.9 2.6 -3.0 0.5
Leg predicted mass (left) 2.5 13.3 21.6 -4.7 -3.0 3.2 -3.5
Trunk fat mass 2.1 8.8 16.7 -4.1 -2.9 2.5 -2.0
Waist circumference 2.2 8.1 14.1 -3.2 -2.4 3.8 -1.6
Number of incorrect matches in round 0.2 0.4 1.1 0.2 1.1 -0.3 0.4
Past tobacco smoking 0.5 0.9 1.9 1.4 0.6 0.6 0.9
Alcohol usually taken with meals 0.8 1.3 2.7 0.5 -1.4 1.6 0.5
Nervous feelings 1.0 1.9 7.1 0.6 2.7 0.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.4 -0.2 0.2 -0.6 0.2
Hearing difficulty/problems with background noise 0.7 1.1 3.8 0.3 -0.3 2.0 -0.6
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 -1.0 0.7 -0.0 -0.5
Had menopause 0.5 0.6 1.4 -1.2 -0.7 0.5 -0.4
Had other major operations 3.0 3.7 7.6 -2.7 -1.9 0.4 -1.8
Forced vital capacity (FVC) 0.3 1.1 2.5 -1.6 0.0 -0.0 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 3.5 -1.9 -1.5 1.2 -1.2
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 2.9 -1.7 -1.7 0.4 0.4
Qualifications: None of the above 0.2 0.3 1.1 0.2 0.2 -0.5 1.0
Financial difficulties in last 2 years 0.1 0.1 0.3 0.5 -0.2 0.4 0.2
Mouth/teeth dental problems 0.1 0.2 0.6 0.1 -0.8 -0.2 0.1
Heart attack 0.9 1.1 2.1 -1.1 -0.8 0.7 -1.4
Allergy 1.4 3.2 4.8 2.2 2.0 -1.2 1.6
Pain all over the body in last month 2.1 2.2 4.5 2.1 1.4 0.4 1.6
Diabetes (self-reported) 1.3 2.0 3.3 -1.8 -1.5 -0.1 -1.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.4 0.0 -0.6 0.4 -0.4
Medication: Ramipril 0.6 0.8 1.8 0.1 0.4 1.0 -1.4
Medication: Simvastatin 1.7 2.4 5.8 -1.1 -2.4 1.0 -1.3
Fluid intelligence score 1.1 2.4 4.2 -2.0 -1.9 0.8 -1.0
Illnesses of siblings 0.3 0.4 1.0 1.0 0.7 0.5 0.2
Neuroticism score 0.1 0.2 0.3 -0.2 0.6 0.6 -0.1
Weight 2.9 14.4 21.6 -4.7 -3.8 3.6 -2.9
Impedance of arm (right) 1.5 7.2 12.8 1.9 3.6 -3.4 1.1
Arm fat percentage (right) 1.0 3.8 6.8 -1.8 -2.6 2.2 0.4
Trunk fat-free mass 3.1 17.7 25.6 -5.1 -3.8 3.6 -4.3
Hip circumference 2.5 10.8 13.5 -3.5 -3.7 3.4 -2.4
Time employed in main current job 0.1 0.1 0.3 0.2 -0.6 -0.4 0.1
Alcohol intake versus 10 years previously 1.9 2.8 4.0 -2.0 1.3 -2.0 -1.3
Father’s age at death 0.8 1.0 3.7 -0.2 1.9 0.1 -0.6
Worrier / anxious feelings 0.8 1.5 3.4 -1.5 1.9 0.4 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.2 -0.5 -1.0 1.1 -0.4
Falls in the last year 0.4 0.5 1.2 0.1 0.3 1.1 0.9
Hair/balding pattern: Pattern 3 0.7 1.0 3.8 0.1 -1.9 0.1 -0.3
Number of live births 2.6 3.7 7.0 -2.5 -0.4 -1.0 -2.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.2 -1.1 -0.1 0.9 -0.7
Pulse rate 0.5 0.8 1.4 -0.9 -1.2 0.9 -0.3
Happiness 0.5 0.6 1.4 -1.2 -0.6 0.8 -0.4
Noisy workplace 1.3 1.6 2.3 -0.4 1.4 -1.5 -1.4
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.6 0.1 -1.6 1.4 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 4.8 -0.1 -2.2 -0.9 0.7
Mouth/teeth dental problems: Dentures 0.3 0.5 1.8 1.3 -0.0 0.5 0.2
Asthma 1.9 3.8 8.8 -2.4 -3.0 0.3 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.4 -0.2 0.4 0.2
Medication: Cholesterol lowering 1.6 2.5 4.2 -1.4 -2.1 -0.1 -1.9
Depression (self-reported) 0.3 0.4 1.5 -0.1 0.1 0.3 1.2
Medication: Lansoprazole 1.4 1.6 4.7 -2.2 -1.1 0.3 -0.7
Prospective memory result 1.8 2.2 5.3 2.3 1.6 -0.2 1.1
Lung cancer (father) 0.6 0.7 1.1 -1.1 -0.3 1.1 -0.6
Illnesses of mother 0.3 0.3 0.8 -0.4 0.2 -0.9 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.5 -0.5 0.1 0.7 -0.7
Pulse wave Arterial Stiffness index 2.5 2.9 4.7 -1.9 -1.0 -1.5 -2.2
Impedance of arm (left) 1.5 7.1 13.9 1.7 3.7 -3.4 0.3
Arm fat mass (right) 2.0 8.2 12.3 -3.5 -3.3 2.8 -1.4
Trunk predicted mass 3.1 17.9 25.5 -5.0 -3.8 3.6 -4.3
Standing height 1.7 16.7 33.4 -5.5 -1.3 1.3 -5.8
Length of working week for main job 0.9 1.0 2.0 1.4 1.3 0.3 -0.1
Exposure to tobacco smoke at home 1.9 2.1 4.9 0.4 1.7 -2.2 -0.8
Breastfed as a baby 2.7 3.3 4.8 -1.7 -2.2 1.4 -1.9
Tense / ‘highly strung’ 1.0 1.6 2.3 0.8 1.5 -1.5 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.5 -1.2 -0.8 -1.2 0.9
Hair/balding pattern: Pattern 4 0.4 0.9 1.4 0.2 -1.1 1.0 1.2
Birth weight of first child 0.4 0.7 1.2 -1.1 0.8 -0.2 -0.9
Peak expiratory flow (PEF) 0.8 1.8 3.8 -1.1 -1.9 1.0 -1.1
Pulse wave reflection index 1.6 2.0 4.4 -1.4 -0.4 -2.1 -1.3
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.7 -0.8 -0.1 -0.4 -0.8
Loud music exposure frequency 1.3 1.5 2.6 -1.6 -1.1 0.3 -1.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.5 -0.8 -1.2 -0.1 0.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.7 -0.4 1.3 0.7 -0.0
Blood clot in the leg (DVT) 1.5 2.0 6.4 1.0 0.1 2.5 0.7
Medication: Paracetamol 0.2 0.3 0.6 0.3 0.7 0.2 -0.8
Headache pain in last month 0.3 0.5 1.2 -0.6 -0.5 -1.1 0.2
Medication for cholesterol, blood pressure or diabetes 2.6 4.3 5.7 2.4 2.0 -1.7 2.1
Glaucoma (self-reported) 1.3 1.5 3.6 -0.4 -1.9 1.5 -0.3
Gout (self-reported) 0.9 1.3 2.3 -0.9 -1.5 1.4 -0.1
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 1.7 -1.3 -1.0 -0.9 -0.9
Medication: Amlodipine 1.0 1.4 2.7 -0.6 -1.6 1.5 -0.2
Medication: Ventolin 100micrograms inhaler 1.7 2.2 6.8 -1.3 -2.6 0.2 -0.5
Birth weight 0.2 0.5 1.3 0.0 -0.3 0.8 1.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.3 0.4 0.5 1.5 -0.1
High blood pressure (siblings) 0.4 0.6 1.9 -0.2 -0.5 -1.4 0.4
Forced vital capacity (FVC), Best measure 0.2 0.7 1.4 -0.9 0.7 -0.5 -1.2
Body fat percentage 1.0 3.9 6.8 -2.6 -2.2 1.9 -0.5
Leg fat percentage (right) 1.2 4.5 8.1 -2.5 -2.8 1.9 0.0
Arm fat-free mass (right) 3.8 19.4 29.9 -5.5 -3.9 3.5 -4.5
Exposure to tobacco smoke outside home 0.2 0.2 0.8 -0.2 -0.3 0.1 -0.9
Comparative body size at age 10 0.2 0.6 2.0 -0.6 -1.4 0.1 0.3
Number of full brothers 0.3 0.4 0.5 0.7 0.7 -0.4 0.6
Worry too long after embarrassment 0.6 1.0 1.6 -0.9 0.1 1.3 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.5 -0.3 -1.6 -1.1 0.9
Wheeze or whistling in the chest in last year 0.2 0.4 0.7 -0.7 -0.5 0.8 0.4
Number of children fathered 0.3 0.3 1.0 -0.1 -0.3 -1.0 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 -0.0 -0.6 0.1 0.2
Age at first live birth 0.4 0.7 2.5 -0.1 -0.1 0.3 1.6
Pulse wave peak to peak time 1.9 2.2 3.1 1.5 1.0 1.6 1.8
Health satisfaction 0.3 0.4 1.5 -1.2 -0.3 0.2 -0.2
Shortness of breath walking on level ground 0.6 0.7 1.9 -0.1 -0.8 1.4 -0.3
Qualifications: College or University degree 0.6 1.8 6.3 0.2 -0.7 2.5 -0.5
Eye problems/disorders: None of the above 1.9 2.2 3.4 1.5 1.1 -1.3 1.8
Mouth/teeth dental problems: Loose teeth 1.2 1.5 2.8 1.7 0.3 -0.2 1.7
Emphysema/chronic bronchitis 1.8 2.0 7.6 0.4 0.3 2.8 -0.5
Medication for pain relief, constipation, heartburn 0.8 1.4 2.9 -0.7 1.4 -1.7 -0.5
Neck or shoulder pain in last month 0.5 0.7 1.8 0.2 -0.9 -0.0 1.4
Medication: Blood pressure 2.8 4.9 7.6 -2.8 -1.8 1.8 -2.4
Angina (self-reported) 0.7 0.9 1.4 -0.4 -1.2 0.8 -1.1
Migraine (self-reported) 0.5 0.6 1.1 -0.7 -1.0 -0.2 -0.8
Medication: Ibuprofen 0.7 0.9 1.5 1.2 0.9 0.7 0.8
Medication: Allopurinol 1.4 1.9 4.2 -1.5 -2.0 1.1 -0.3
Medication: Omeprazole 0.2 0.2 0.6 -0.4 0.8 0.2 0.1
Medication: Seretide 50 evohaler 0.2 0.3 0.5 0.7 0.2 0.6 0.0
Mean time to correctly identify matches 0.3 0.6 0.7 0.8 0.8 0.5 0.7
Heart disease (mother) 0.6 0.8 1.8 -1.3 -0.8 0.6 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.9 4.6 7.3 -2.7 -2.3 1.5 -1.9
Whole body fat mass 2.1 9.0 15.8 -4.0 -3.1 2.6 -1.9
Leg fat mass (right) 2.5 9.7 15.9 -4.0 -3.7 2.7 -1.5
Arm predicted mass (right) 3.8 19.2 29.5 -5.4 -3.9 3.6 -4.4
Pulse rate, automated reading 0.6 2.1 4.5 -2.1 -0.5 1.4 -1.3
Alcohol intake frequency. 0.5 1.2 2.3 -0.5 -1.4 -0.6 -1.5
Comparative height size at age 10 1.0 5.6 14.6 -3.8 -0.4 -0.1 -2.8
Number of full sisters 1.8 2.2 3.9 -1.3 -2.0 0.8 -1.7
Suffer from ‘nerves’ 2.0 3.2 5.6 2.0 1.6 0.7 2.4
Overall health rating 0.3 0.7 1.9 -0.6 -0.0 1.4 -0.8
Chest pain or discomfort 0.4 0.6 2.0 0.6 -0.2 1.4 0.2
Had major operations 1.7 2.0 5.6 0.1 -2.4 1.5 0.0
Age at last live birth 0.2 0.3 0.5 -0.6 -0.4 -0.7 -0.4
Family relationship satisfaction 0.4 0.5 1.9 0.0 0.2 -1.4 0.4
Leg pain on walking 1.1 1.3 3.0 -1.7 1.1 0.7 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 -0.0 -0.2 -1.1 -0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.7 0.8 0.8 0.4 -0.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.2 0.5 0.1 0.1
Medication: Aspirin 2.2 2.9 6.0 -1.4 -2.4 1.9 -0.5
Supplements: Vitamin C 0.3 0.3 0.5 -0.7 -0.3 0.7 -0.3
Knee pain experienced in last month 0.5 0.8 1.8 0.3 1.3 1.0 0.5
Hypertension (Self-reported) 1.6 4.3 11.8 -1.7 -0.6 3.4 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.2 -0.6 -1.5 0.7 -0.8
Illnesses of father: Heart disease 0.3 0.4 0.8 -0.9 -0.7 -0.6 -0.2
Illnesses of siblings: Diabetes 0.8 0.9 2.5 -0.9 -1.6 0.1 -0.7
Smoking status: Previous 0.7 1.1 1.4 -1.2 -1.2 -1.1 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.3 9.7 -1.7 0.7 0.6 -3.1
Whole body fat-free mass 3.0 17.3 26.4 -5.1 -3.6 3.6 -4.1
Leg fat-free mass (right) 2.4 13.0 20.2 -4.5 -2.9 3.3 -3.6
Arm fat percentage (left) 1.0 3.8 6.5 -1.9 -2.5 2.3 -0.1
Average weekly red wine intake 1.3 1.8 3.6 1.6 -0.2 1.9 1.1
Handedness (chirality/laterality): Left-handed 0.9 1.0 3.7 0.4 0.4 -0.3 1.9
Mood swings 0.2 0.4 1.1 -1.0 0.5 -0.3 0.6
Loneliness, isolation 0.3 0.4 0.5 -0.7 -0.7 0.7 0.2
Long-standing illness, disability or infirmity 1.5 2.3 4.7 -1.5 0.9 1.3 -2.2
Ever had bowel cancer screening 0.4 0.4 1.3 -0.1 0.5 -1.2 -0.3
Diabetes diagnosed by doctor 1.1 1.8 2.5 -1.4 -1.6 0.7 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 3.1 -0.2 -0.3 -1.8 -0.2
Friendships satisfaction 0.2 0.3 0.6 0.2 -0.6 0.8 -0.1
Qualifications: nursing, teaching 0.8 1.2 2.3 1.5 0.1 0.5 1.5
Commuting to job workplace: Walk 1.3 1.4 3.6 1.3 -0.3 0.7 1.9
Eye problems/disorders: Cataract 2.1 2.4 3.8 -1.9 -1.1 1.3 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 3.4 -1.8 -1.2 -0.5 -0.9
Medication for cholesterol 1.8 2.7 7.1 -1.1 -0.8 -2.7 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 0.3 0.5 -0.9 -0.2
Back pain experienced in last month 0.1 0.2 0.3 0.2 0.5 0.6 -0.2
Mineral and other dietary supplements 1.9 2.5 4.0 2.0 -0.8 1.6 1.7
Breast cancer (self-reported) 0.3 0.4 1.3 -0.4 0.2 -1.1 0.4
Asthma (self-reported) 2.0 3.9 8.0 -2.5 -2.8 0.6 -0.9
Osteoporosis (self-reported) 0.2 0.2 0.3 -0.4 0.5 -0.5 0.2
Osteoarthritis (self-reported) 0.2 0.3 0.7 -0.4 0.4 0.3 -0.8
Medication: Aspirin 2.2 2.9 6.2 -1.3 -2.5 1.9 -0.2
Medication: Gliclazide 0.5 0.5 0.7 0.4 0.9 -0.9 0.7
Illnesses of father: None of the above (group 1) 2.3 2.8 5.6 -2.3 -2.4 0.2 -0.6
Smoking status: Current 0.7 1.1 2.3 -1.0 1.0 -0.5 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.0 0.1 0.1 -0.3 0.3 -0.0
Whole body water mass 2.9 16.8 25.2 -5.0 -3.5 3.7 -4.0
Leg predicted mass (right) 2.4 12.8 19.8 -4.5 -2.9 3.2 -3.6
Arm fat mass (left) 2.1 8.5 11.2 -3.3 -3.4 3.1 -1.4
Number of self-reported non-cancer illnesses 2.5 4.4 7.1 -2.7 -2.2 0.5 -2.3
Average weekly champagne plus white wine intake 0.6 0.8 2.5 -0.4 -0.3 -0.5 -1.6
Miserableness 0.8 1.4 3.0 -1.1 -1.0 1.7 0.7
Guilty feelings 0.3 0.4 0.6 0.8 -0.1 0.6 -0.8
Wears glasses or contact lenses 1.7 1.9 2.8 -1.7 -1.4 -0.4 -1.6
Ever taken oral contraceptive pill 0.7 0.8 1.6 0.3 -1.1 0.4 1.2
Hearing aid user 1.7 1.9 4.6 -1.4 -0.3 1.1 -2.1
Mother’s age at death 0.5 0.6 2.1 0.3 0.3 1.5 -0.3
Financial situation satisfaction 0.3 0.3 1.0 -0.5 1.0 0.2 -0.1
Tinnitus: Yes, now most or all of the time 2.1 2.4 4.0 -2.0 -1.2 -1.1 -1.8
Commuting to job workplace: Public transport 2.7 3.2 5.0 -2.0 -0.7 -1.9 -2.2
Eye problems/disorders: Glaucoma 1.1 1.3 3.1 0.8 -1.1 1.8 -0.4
Medication: Blood pressure 1.5 2.8 10.3 -0.0 0.9 3.2 0.4
Pain type(s) experienced in last month: Hip pain 1.8 2.3 4.5 -2.1 -1.6 0.4 -1.3
Supplements: Fish oil (including cod liver oil) 1.6 2.1 4.8 -2.2 0.4 -0.9 -1.6
High cholesterol (Self-reported) 1.5 2.6 4.0 -2.0 -1.6 -0.3 -1.9
Medication: Bendroflumethiazide 0.6 0.8 2.5 -0.9 -0.1 1.6 -0.4
Medication: Paracetamol 0.6 0.9 3.2 0.4 1.8 -0.2 -0.0
Medication: Lisinopril 1.4 1.8 3.2 -1.6 -0.7 0.8 -1.8
Medication: Atorvastatin 0.2 0.2 0.7 -0.8 -0.2 -0.3 -0.2
Illnesses of father: High blood pressure 3.8 4.7 6.2 2.4 1.0 2.5 2.4
Alcohol drinker status: Never 0.4 0.5 1.2 -0.6 -1.1 0.4 -0.6
Ever smoked 0.1 0.2 0.4 -0.3 0.7 -0.4 -0.4
Basal metabolic rate 3.1 17.1 26.7 -5.2 -3.7 3.6 -3.9
Leg fat percentage (left) 1.3 4.6 8.1 -2.5 -2.8 2.1 -0.0
Arm fat-free mass (left) 3.7 18.6 29.3 -5.4 -4.1 3.8 -3.7
Number of operations (self-reported) 2.3 3.4 6.0 -2.5 -2.0 0.8 -1.7
Average weekly beer plus cider intake 0.1 0.1 0.3 -0.0 0.5 -0.1 0.2
Irritability 0.7 1.1 4.5 0.1 -0.2 -0.1 2.1
Risk taking 0.5 0.7 1.6 0.4 0.8 -1.3 -0.7
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.2 0.3 -1.0 -1.5 0.7
Fractured/broken bones in last 5 years 0.3 0.3 0.8 0.2 0.7 -0.9 0.2
Age started oral contraceptive pill 0.9 1.1 2.9 0.5 0.0 1.7 1.0
Diastolic blood pressure, automated reading 0.8 2.4 5.9 -0.3 -1.9 2.4 0.0
Ever depressed for a whole week 1.9 2.4 4.4 -2.1 -1.7 -0.0 -1.4
Unable to work because of sickness or disability 2.5 3.3 11.5 -0.1 -3.4 1.2 0.3
Commuting to job workplace: Cycle 1.0 1.1 4.1 -0.4 -2.0 0.2 -0.5
Myopia 0.6 0.9 1.6 -0.9 -0.1 -1.1 -1.3
Vascular/heart problems diagnosed by doctor 1.7 4.8 11.4 1.9 0.6 -3.4 1.9
Cholesterol lowering medication 0.3 0.5 1.4 -0.2 0.4 1.2 0.6
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.5 0.1 0.7 0.1
Pain experienced in last month 0.6 0.9 1.3 -1.0 -1.0 -0.5 -1.1
Supplements: Calcium 2.3 2.6 5.8 -0.9 0.6 -2.4 -1.9
Basal cell carcinoma (self-reported) 0.4 0.5 1.0 -0.2 -1.0 -0.4 1.0
Heart attack/myocardial infarction (self-reported) 0.9 1.1 1.6 -1.1 -1.1 0.8 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 5.4 1.1 0.2 2.3 0.7
Heart disease (siblings) 0.2 0.2 0.6 -0.4 -0.8 -0.2 0.3
Alcohol drinker status: Previous 0.8 0.9 3.6 -0.3 -1.9 0.3 -0.0
Pack years of smoking 0.4 0.6 1.2 0.2 1.1 0.4 -0.9
Impedance of whole body 1.4 7.0 13.2 1.1 3.6 -3.6 0.5
Leg fat mass (left) 2.6 10.2 16.9 -4.1 -3.6 2.8 -1.7
Arm predicted mass (left) 3.6 18.2 28.1 -5.3 -3.7 4.0 -3.9