Hub : Genes

TXLNA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.038	0.0160	0.00087	0.036	0.024	0.014	0.029	0.024	3.0e-05	0.00054	0.00630	0.00018	0.00050
2	GTEx	Brain Cerebellum	0.144	0.0590	0.00540	0.136	NA	0.097	NA	0.123	8.1e-05	NA	0.00083	NA	0.00017
3	GTEx	Brain Frontal Cortex BA9	0.223	0.0917	0.00760	-0.011	NA	-0.001	NA	-0.011	9.1e-01	NA	0.33000	NA	0.92000
4	GTEx	Nerve Tibial	0.095	0.0502	0.00870	-0.004	NA	-0.003	NA	-0.003	8.5e-01	NA	0.68000	NA	0.70000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.3	2.9	1.4	1.7	0.3	0.4
Bipolar Disorder or Schizophrenia	1.0	2.5	4.0	2.0	1.5	1.8	0.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.9	-1.7	-0.2	0.5	0.9
Depression (Nagel 2018)	1.6	2.4	4.3	-2.1	-1.9	-1.2	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.8	-1.5	-1.0	-0.6	-1.9
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.7	0.9	0.3	0.6
Schizophrenia (2018)	0.8	1.8	4.5	1.4	0.6	2.1	0.5
Schizophrenia vs Biploar Disorder	0.6	0.7	1.1	0.7	-0.7	1.0	0.9
Worry (Nagel 2018)	0.6	1.2	3.7	0.6	1.9	-0.6	0.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.6	-0.3	0.0	-0.8
Alzheimer’s Disease (in father)	0.4	0.5	0.9	0.7	0.4	-1.0	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	0.6	0.1	-0.4	-1.1
Crohns Disease (2017)	0.1	0.3	0.6	0.8	-0.1	-0.6	-0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	0.4	-0.2	-0.4	-0.1
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.1	0.1	-0.0	0.3
Major Depression (MDD)	0.6	0.7	2.0	-0.2	0.0	1.4	-0.9
Reaction Time	0.7	1.2	1.8	1.3	0.9	0.8	1.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.9	-1.8	-2.0	-0.4	-1.4
Breast Cancer	1.4	3.4	4.3	-1.7	-1.9	2.1	-1.7
Ovarian Cancer	0.7	1.0	1.9	0.3	-1.4	-0.4	1.3
Prostate Cancer	2.5	3.5	4.8	0.9	1.9	2.2	2.2
Age at First Birth	0.9	1.3	2.0	-0.1	-1.3	1.3	1.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	1.6	-1.2	-0.8	1.3	-0.7
Coronary Artery Disease (CAD)	0.7	0.8	1.7	-0.7	0.1	-1.3	-1.1
Crohns Disease (2012)	0.8	1.3	4.5	-0.4	-0.4	0.6	-2.1
Mean Putamen Volume	0.1	0.2	0.3	0.2	0.4	0.4	0.5
Fasting Glucose	2.4	2.9	7.2	-1.6	-1.3	-0.5	-2.7
HbA1C	0.7	0.8	2.2	-1.5	0.4	0.0	-0.9
HDL Cholesterol	0.2	0.3	0.8	0.9	-0.5	-0.5	0.4
LDL Cholesterol	0.5	0.8	1.6	0.6	1.3	-0.9	0.5
Lupus	0.7	1.1	3.1	-1.0	-1.8	0.1	-0.4
Neuroticism (2016)	0.2	0.3	0.7	-0.8	-0.2	0.1	0.7
Primary Biliary Cirrhosis	0.3	0.5	1.4	-0.5	0.3	0.4	-1.2
Rheumatoid Arthritis	1.2	1.7	3.2	-1.6	-0.2	-1.1	-1.8
Schizophrenia (2014)	1.5	3.3	5.7	2.3	0.8	2.4	1.4
Triglycerides	0.2	0.3	0.6	-0.8	0.5	-0.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	-0.1	0.9	0.0	0.8
Ulcerative Colitis	0.2	0.3	0.8	-0.6	-0.9	0.2	-0.4
Blood Eosinophil Count	0.3	2.4	5.6	-2.4	-1.6	-1.1	-0.4
Blood Platelet Count	0.1	0.8	1.7	-1.3	-0.2	-1.2	-0.4
Blood Red Count	0.1	1.4	3.0	-1.5	-0.4	-0.3	-1.7
Blood White Count	1.2	9.1	19.9	-2.9	-1.7	-2.4	-4.5
Heel T-Score	0.5	3.9	11.6	-1.2	-3.4	0.3	1.6
BMI	1.9	11.2	16.4	-4.0	-3.9	2.9	-2.3
Height	1.3	25.5	47.6	-6.5	-2.6	2.2	-6.9
Waist Hip Ratio (WHR)	0.2	0.9	2.7	-0.5	1.6	0.9	-0.2
Systolic Blood Pressure	0.1	0.4	1.1	0.6	-0.5	-0.0	-1.1
Smoking Status	1.3	3.1	5.8	-2.2	-0.3	-1.3	-2.4
Allergy or Eczema	0.3	0.8	2.0	-0.9	-0.5	0.2	-1.4
Cardiovascular Disease	0.9	3.1	6.3	-2.5	-0.2	1.5	-1.9
Hypothyroidism (self reported)	0.3	0.6	1.3	-1.0	-0.3	0.1	-1.1
Respiratory disease	1.2	2.7	4.3	-1.8	-2.1	1.0	-1.6
Type 2 Diabetes (T2D) (2018)	2.0	3.7	6.6	-1.7	-2.6	1.8	-1.4
Lung FEV1/FVC ratio	0.9	4.6	13.1	-0.6	-2.2	3.6	0.2
Lung FVC	0.1	0.7	2.1	0.7	-0.1	0.2	1.5
Neuroticism	0.1	0.2	0.5	-0.2	0.7	0.3	-0.5
Chronotype (morning person)	0.3	0.8	2.2	1.5	0.2	-0.9	0.4
Hair Pigment	0.0	0.7	2.7	-0.3	-0.2	0.2	1.6
Tanning	0.1	1.3	2.6	1.5	-0.5	1.6	0.0
Hand grip strength (left)	1.1	2.9	5.9	-1.8	-2.4	1.4	-0.7
Number of treatments/medications taken	1.4	2.6	6.2	-2.5	-0.3	0.9	-1.8
Average weekly spirits intake	0.1	0.1	0.4	0.1	0.0	-0.7	0.3
Sensitivity / hurt feelings	0.4	0.6	1.0	-0.7	0.2	-1.0	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.9	-0.6	-1.0	-0.7	0.7
Hearing difficulty/problems: Yes	1.3	2.0	3.1	-1.8	-1.4	0.7	-1.6
Relative age of first facial hair	0.6	1.2	1.7	-1.3	-1.1	0.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	0.0	-0.0	-0.2	-1.3
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.5	-0.6	-0.9	2.1	0.6
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	-0.8	-0.2	0.1	-0.8
Systolic blood pressure, automated reading	0.3	0.8	2.2	1.5	-0.4	0.8	0.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.9	-0.1	-2.4	1.3	-1.0
Angina	0.6	0.9	1.3	-0.5	-1.1	0.8	-1.1
Medication for hormone replacement therapy	0.6	0.7	1.4	1.2	-0.5	0.4	1.0
Vitamin and mineral supplements	0.5	0.7	2.1	0.3	-1.4	0.7	0.2
Supplements: Zinc	0.4	0.4	0.6	-0.5	0.6	-0.7	-0.8
Medication: Co-codamol	1.3	1.5	4.1	-2.0	-0.9	-0.3	-1.1
Medication: Metformin	1.5	2.1	2.8	-1.7	-1.6	0.8	-1.5
Diabetes (father)	1.1	1.4	3.7	0.8	1.9	0.8	-0.7
Diabetes (mother)	1.3	1.7	4.5	-1.5	0.2	-0.1	-2.1
Severe depression (siblings)	0.8	0.9	2.5	1.6	0.9	-0.4	-0.4
Pack years adult smoking proportion	0.5	0.7	2.0	0.5	1.4	-0.1	-0.7
Impedance of leg (right)	0.9	4.4	9.7	0.8	2.6	-3.1	0.6
Leg fat-free mass (left)	2.6	13.7	22.8	-4.8	-3.0	3.1	-3.6
Trunk fat percentage	0.9	3.6	7.6	-2.8	-1.9	1.7	-0.8
Hand grip strength (right)	0.5	1.4	2.3	-1.0	-1.5	1.0	-1.1
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.0	-1.1	-1.2	-0.0
Current tobacco smoking	0.9	1.5	2.8	-0.9	1.4	-0.7	-1.7
Average weekly fortified wine intake	0.3	0.4	0.9	-0.4	-1.0	0.7	0.1
Maternal smoking around birth	1.1	1.5	3.8	-0.7	0.5	-1.3	-1.9
Fed-up feelings	0.2	0.4	1.2	-1.1	-0.3	-0.6	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	-1.1	-1.3	-0.6	-0.0
Relative age voice broke	2.2	3.4	4.8	-2.1	-1.7	-1.1	-2.2
Taking other prescription medications	2.4	3.7	7.3	-2.7	-1.6	0.7	-2.0
Age when periods started (menarche)	0.8	1.9	3.5	1.9	1.3	1.5	0.4
Bilateral oophorectomy (both ovaries removed)	1.9	2.1	3.2	-1.7	-1.8	-0.8	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.0	-1.5	-1.7	1.2	-0.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	5.5	-1.4	-2.3	-0.1	-0.8
Qualifications: CSEs or equivalent	0.7	1.0	2.1	1.3	1.4	0.1	0.4
Serious illness, injury or assault to yourself	0.8	0.9	2.0	0.6	-1.2	1.4	-0.0
High blood pressure	1.6	4.5	10.5	-1.8	-0.7	3.2	-2.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	-1.3	-0.5	-0.7	-1.4
Multivitamins +/- minerals	0.0	0.1	0.1	-0.1	0.4	-0.2	0.0
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.8	-0.7	-0.4	0.0
Supplements: Glucosamine	0.3	0.4	1.1	-1.0	0.1	-0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	-0.7	0.5	-0.4	-0.5
Medication: Atenolol	1.2	1.6	3.7	0.8	-1.1	1.9	0.8
Medication: Levothyroxine sodium	0.5	0.9	2.0	-1.2	-0.2	-1.4	-0.5
Sitting height	2.4	16.9	33.4	-5.8	-1.7	0.2	-5.6
Chronic bronchitis/emphysema (father)	1.6	1.8	4.8	1.4	2.2	0.3	0.7
High blood pressure (mother)	0.8	1.2	2.0	1.1	-1.4	-0.1	1.1
Body mass index (BMI)	1.6	6.7	11.3	-2.3	-3.4	3.2	-0.3
Impedance of leg (left)	0.9	4.2	9.0	0.9	2.6	-3.0	0.5
Leg predicted mass (left)	2.5	13.3	21.6	-4.7	-3.0	3.2	-3.5
Trunk fat mass	2.1	8.8	16.7	-4.1	-2.9	2.5	-2.0
Waist circumference	2.2	8.1	14.1	-3.2	-2.4	3.8	-1.6
Number of incorrect matches in round	0.2	0.4	1.1	0.2	1.1	-0.3	0.4
Past tobacco smoking	0.5	0.9	1.9	1.4	0.6	0.6	0.9
Alcohol usually taken with meals	0.8	1.3	2.7	0.5	-1.4	1.6	0.5
Nervous feelings	1.0	1.9	7.1	0.6	2.7	0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.2	0.2	-0.6	0.2
Hearing difficulty/problems with background noise	0.7	1.1	3.8	0.3	-0.3	2.0	-0.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	-1.0	0.7	-0.0	-0.5
Had menopause	0.5	0.6	1.4	-1.2	-0.7	0.5	-0.4
Had other major operations	3.0	3.7	7.6	-2.7	-1.9	0.4	-1.8
Forced vital capacity (FVC)	0.3	1.1	2.5	-1.6	0.0	-0.0	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.5	-1.9	-1.5	1.2	-1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.9	-1.7	-1.7	0.4	0.4
Qualifications: None of the above	0.2	0.3	1.1	0.2	0.2	-0.5	1.0
Financial difficulties in last 2 years	0.1	0.1	0.3	0.5	-0.2	0.4	0.2
Mouth/teeth dental problems	0.1	0.2	0.6	0.1	-0.8	-0.2	0.1
Heart attack	0.9	1.1	2.1	-1.1	-0.8	0.7	-1.4
Allergy	1.4	3.2	4.8	2.2	2.0	-1.2	1.6
Pain all over the body in last month	2.1	2.2	4.5	2.1	1.4	0.4	1.6
Diabetes (self-reported)	1.3	2.0	3.3	-1.8	-1.5	-0.1	-1.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	0.0	-0.6	0.4	-0.4
Medication: Ramipril	0.6	0.8	1.8	0.1	0.4	1.0	-1.4
Medication: Simvastatin	1.7	2.4	5.8	-1.1	-2.4	1.0	-1.3
Fluid intelligence score	1.1	2.4	4.2	-2.0	-1.9	0.8	-1.0
Illnesses of siblings	0.3	0.4	1.0	1.0	0.7	0.5	0.2
Neuroticism score	0.1	0.2	0.3	-0.2	0.6	0.6	-0.1
Weight	2.9	14.4	21.6	-4.7	-3.8	3.6	-2.9
Impedance of arm (right)	1.5	7.2	12.8	1.9	3.6	-3.4	1.1
Arm fat percentage (right)	1.0	3.8	6.8	-1.8	-2.6	2.2	0.4
Trunk fat-free mass	3.1	17.7	25.6	-5.1	-3.8	3.6	-4.3
Hip circumference	2.5	10.8	13.5	-3.5	-3.7	3.4	-2.4
Time employed in main current job	0.1	0.1	0.3	0.2	-0.6	-0.4	0.1
Alcohol intake versus 10 years previously	1.9	2.8	4.0	-2.0	1.3	-2.0	-1.3
Father’s age at death	0.8	1.0	3.7	-0.2	1.9	0.1	-0.6
Worrier / anxious feelings	0.8	1.5	3.4	-1.5	1.9	0.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.2	-0.5	-1.0	1.1	-0.4
Falls in the last year	0.4	0.5	1.2	0.1	0.3	1.1	0.9
Hair/balding pattern: Pattern 3	0.7	1.0	3.8	0.1	-1.9	0.1	-0.3
Number of live births	2.6	3.7	7.0	-2.5	-0.4	-1.0	-2.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.2	-1.1	-0.1	0.9	-0.7
Pulse rate	0.5	0.8	1.4	-0.9	-1.2	0.9	-0.3
Happiness	0.5	0.6	1.4	-1.2	-0.6	0.8	-0.4
Noisy workplace	1.3	1.6	2.3	-0.4	1.4	-1.5	-1.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.6	0.1	-1.6	1.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.8	-0.1	-2.2	-0.9	0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	1.8	1.3	-0.0	0.5	0.2
Asthma	1.9	3.8	8.8	-2.4	-3.0	0.3	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	-0.2	0.4	0.2
Medication: Cholesterol lowering	1.6	2.5	4.2	-1.4	-2.1	-0.1	-1.9
Depression (self-reported)	0.3	0.4	1.5	-0.1	0.1	0.3	1.2
Medication: Lansoprazole	1.4	1.6	4.7	-2.2	-1.1	0.3	-0.7
Prospective memory result	1.8	2.2	5.3	2.3	1.6	-0.2	1.1
Lung cancer (father)	0.6	0.7	1.1	-1.1	-0.3	1.1	-0.6
Illnesses of mother	0.3	0.3	0.8	-0.4	0.2	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.5	0.1	0.7	-0.7
Pulse wave Arterial Stiffness index	2.5	2.9	4.7	-1.9	-1.0	-1.5	-2.2
Impedance of arm (left)	1.5	7.1	13.9	1.7	3.7	-3.4	0.3
Arm fat mass (right)	2.0	8.2	12.3	-3.5	-3.3	2.8	-1.4
Trunk predicted mass	3.1	17.9	25.5	-5.0	-3.8	3.6	-4.3
Standing height	1.7	16.7	33.4	-5.5	-1.3	1.3	-5.8
Length of working week for main job	0.9	1.0	2.0	1.4	1.3	0.3	-0.1
Exposure to tobacco smoke at home	1.9	2.1	4.9	0.4	1.7	-2.2	-0.8
Breastfed as a baby	2.7	3.3	4.8	-1.7	-2.2	1.4	-1.9
Tense / ‘highly strung’	1.0	1.6	2.3	0.8	1.5	-1.5	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.5	-1.2	-0.8	-1.2	0.9
Hair/balding pattern: Pattern 4	0.4	0.9	1.4	0.2	-1.1	1.0	1.2
Birth weight of first child	0.4	0.7	1.2	-1.1	0.8	-0.2	-0.9
Peak expiratory flow (PEF)	0.8	1.8	3.8	-1.1	-1.9	1.0	-1.1
Pulse wave reflection index	1.6	2.0	4.4	-1.4	-0.4	-2.1	-1.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	-0.8	-0.1	-0.4	-0.8
Loud music exposure frequency	1.3	1.5	2.6	-1.6	-1.1	0.3	-1.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-0.8	-1.2	-0.1	0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	-0.4	1.3	0.7	-0.0
Blood clot in the leg (DVT)	1.5	2.0	6.4	1.0	0.1	2.5	0.7
Medication: Paracetamol	0.2	0.3	0.6	0.3	0.7	0.2	-0.8
Headache pain in last month	0.3	0.5	1.2	-0.6	-0.5	-1.1	0.2
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	5.7	2.4	2.0	-1.7	2.1
Glaucoma (self-reported)	1.3	1.5	3.6	-0.4	-1.9	1.5	-0.3
Gout (self-reported)	0.9	1.3	2.3	-0.9	-1.5	1.4	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.7	-1.3	-1.0	-0.9	-0.9
Medication: Amlodipine	1.0	1.4	2.7	-0.6	-1.6	1.5	-0.2
Medication: Ventolin 100micrograms inhaler	1.7	2.2	6.8	-1.3	-2.6	0.2	-0.5
Birth weight	0.2	0.5	1.3	0.0	-0.3	0.8	1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.3	0.4	0.5	1.5	-0.1
High blood pressure (siblings)	0.4	0.6	1.9	-0.2	-0.5	-1.4	0.4
Forced vital capacity (FVC), Best measure	0.2	0.7	1.4	-0.9	0.7	-0.5	-1.2
Body fat percentage	1.0	3.9	6.8	-2.6	-2.2	1.9	-0.5
Leg fat percentage (right)	1.2	4.5	8.1	-2.5	-2.8	1.9	0.0
Arm fat-free mass (right)	3.8	19.4	29.9	-5.5	-3.9	3.5	-4.5
Exposure to tobacco smoke outside home	0.2	0.2	0.8	-0.2	-0.3	0.1	-0.9
Comparative body size at age 10	0.2	0.6	2.0	-0.6	-1.4	0.1	0.3
Number of full brothers	0.3	0.4	0.5	0.7	0.7	-0.4	0.6
Worry too long after embarrassment	0.6	1.0	1.6	-0.9	0.1	1.3	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.5	-0.3	-1.6	-1.1	0.9
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.7	-0.5	0.8	0.4
Number of children fathered	0.3	0.3	1.0	-0.1	-0.3	-1.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.0	-0.6	0.1	0.2
Age at first live birth	0.4	0.7	2.5	-0.1	-0.1	0.3	1.6
Pulse wave peak to peak time	1.9	2.2	3.1	1.5	1.0	1.6	1.8
Health satisfaction	0.3	0.4	1.5	-1.2	-0.3	0.2	-0.2
Shortness of breath walking on level ground	0.6	0.7	1.9	-0.1	-0.8	1.4	-0.3
Qualifications: College or University degree	0.6	1.8	6.3	0.2	-0.7	2.5	-0.5
Eye problems/disorders: None of the above	1.9	2.2	3.4	1.5	1.1	-1.3	1.8
Mouth/teeth dental problems: Loose teeth	1.2	1.5	2.8	1.7	0.3	-0.2	1.7
Emphysema/chronic bronchitis	1.8	2.0	7.6	0.4	0.3	2.8	-0.5
Medication for pain relief, constipation, heartburn	0.8	1.4	2.9	-0.7	1.4	-1.7	-0.5
Neck or shoulder pain in last month	0.5	0.7	1.8	0.2	-0.9	-0.0	1.4
Medication: Blood pressure	2.8	4.9	7.6	-2.8	-1.8	1.8	-2.4
Angina (self-reported)	0.7	0.9	1.4	-0.4	-1.2	0.8	-1.1
Migraine (self-reported)	0.5	0.6	1.1	-0.7	-1.0	-0.2	-0.8
Medication: Ibuprofen	0.7	0.9	1.5	1.2	0.9	0.7	0.8
Medication: Allopurinol	1.4	1.9	4.2	-1.5	-2.0	1.1	-0.3
Medication: Omeprazole	0.2	0.2	0.6	-0.4	0.8	0.2	0.1
Medication: Seretide 50 evohaler	0.2	0.3	0.5	0.7	0.2	0.6	0.0
Mean time to correctly identify matches	0.3	0.6	0.7	0.8	0.8	0.5	0.7
Heart disease (mother)	0.6	0.8	1.8	-1.3	-0.8	0.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.9	4.6	7.3	-2.7	-2.3	1.5	-1.9
Whole body fat mass	2.1	9.0	15.8	-4.0	-3.1	2.6	-1.9
Leg fat mass (right)	2.5	9.7	15.9	-4.0	-3.7	2.7	-1.5
Arm predicted mass (right)	3.8	19.2	29.5	-5.4	-3.9	3.6	-4.4
Pulse rate, automated reading	0.6	2.1	4.5	-2.1	-0.5	1.4	-1.3
Alcohol intake frequency.	0.5	1.2	2.3	-0.5	-1.4	-0.6	-1.5
Comparative height size at age 10	1.0	5.6	14.6	-3.8	-0.4	-0.1	-2.8
Number of full sisters	1.8	2.2	3.9	-1.3	-2.0	0.8	-1.7
Suffer from ‘nerves’	2.0	3.2	5.6	2.0	1.6	0.7	2.4
Overall health rating	0.3	0.7	1.9	-0.6	-0.0	1.4	-0.8
Chest pain or discomfort	0.4	0.6	2.0	0.6	-0.2	1.4	0.2
Had major operations	1.7	2.0	5.6	0.1	-2.4	1.5	0.0
Age at last live birth	0.2	0.3	0.5	-0.6	-0.4	-0.7	-0.4
Family relationship satisfaction	0.4	0.5	1.9	0.0	0.2	-1.4	0.4
Leg pain on walking	1.1	1.3	3.0	-1.7	1.1	0.7	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.0	-0.2	-1.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.7	0.8	0.8	0.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	0.5	0.1	0.1
Medication: Aspirin	2.2	2.9	6.0	-1.4	-2.4	1.9	-0.5
Supplements: Vitamin C	0.3	0.3	0.5	-0.7	-0.3	0.7	-0.3
Knee pain experienced in last month	0.5	0.8	1.8	0.3	1.3	1.0	0.5
Hypertension (Self-reported)	1.6	4.3	11.8	-1.7	-0.6	3.4	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.2	-0.6	-1.5	0.7	-0.8
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.9	-0.7	-0.6	-0.2
Illnesses of siblings: Diabetes	0.8	0.9	2.5	-0.9	-1.6	0.1	-0.7
Smoking status: Previous	0.7	1.1	1.4	-1.2	-1.2	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.7	-1.7	0.7	0.6	-3.1
Whole body fat-free mass	3.0	17.3	26.4	-5.1	-3.6	3.6	-4.1
Leg fat-free mass (right)	2.4	13.0	20.2	-4.5	-2.9	3.3	-3.6
Arm fat percentage (left)	1.0	3.8	6.5	-1.9	-2.5	2.3	-0.1
Average weekly red wine intake	1.3	1.8	3.6	1.6	-0.2	1.9	1.1
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.7	0.4	0.4	-0.3	1.9
Mood swings	0.2	0.4	1.1	-1.0	0.5	-0.3	0.6
Loneliness, isolation	0.3	0.4	0.5	-0.7	-0.7	0.7	0.2
Long-standing illness, disability or infirmity	1.5	2.3	4.7	-1.5	0.9	1.3	-2.2
Ever had bowel cancer screening	0.4	0.4	1.3	-0.1	0.5	-1.2	-0.3
Diabetes diagnosed by doctor	1.1	1.8	2.5	-1.4	-1.6	0.7	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.1	-0.2	-0.3	-1.8	-0.2
Friendships satisfaction	0.2	0.3	0.6	0.2	-0.6	0.8	-0.1
Qualifications: nursing, teaching	0.8	1.2	2.3	1.5	0.1	0.5	1.5
Commuting to job workplace: Walk	1.3	1.4	3.6	1.3	-0.3	0.7	1.9
Eye problems/disorders: Cataract	2.1	2.4	3.8	-1.9	-1.1	1.3	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.4	-1.8	-1.2	-0.5	-0.9
Medication for cholesterol	1.8	2.7	7.1	-1.1	-0.8	-2.7	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.3	0.5	-0.9	-0.2
Back pain experienced in last month	0.1	0.2	0.3	0.2	0.5	0.6	-0.2
Mineral and other dietary supplements	1.9	2.5	4.0	2.0	-0.8	1.6	1.7
Breast cancer (self-reported)	0.3	0.4	1.3	-0.4	0.2	-1.1	0.4
Asthma (self-reported)	2.0	3.9	8.0	-2.5	-2.8	0.6	-0.9
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.4	0.5	-0.5	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.4	0.4	0.3	-0.8
Medication: Aspirin	2.2	2.9	6.2	-1.3	-2.5	1.9	-0.2
Medication: Gliclazide	0.5	0.5	0.7	0.4	0.9	-0.9	0.7
Illnesses of father: None of the above (group 1)	2.3	2.8	5.6	-2.3	-2.4	0.2	-0.6
Smoking status: Current	0.7	1.1	2.3	-1.0	1.0	-0.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	0.1	-0.3	0.3	-0.0
Whole body water mass	2.9	16.8	25.2	-5.0	-3.5	3.7	-4.0
Leg predicted mass (right)	2.4	12.8	19.8	-4.5	-2.9	3.2	-3.6
Arm fat mass (left)	2.1	8.5	11.2	-3.3	-3.4	3.1	-1.4
Number of self-reported non-cancer illnesses	2.5	4.4	7.1	-2.7	-2.2	0.5	-2.3
Average weekly champagne plus white wine intake	0.6	0.8	2.5	-0.4	-0.3	-0.5	-1.6
Miserableness	0.8	1.4	3.0	-1.1	-1.0	1.7	0.7
Guilty feelings	0.3	0.4	0.6	0.8	-0.1	0.6	-0.8
Wears glasses or contact lenses	1.7	1.9	2.8	-1.7	-1.4	-0.4	-1.6
Ever taken oral contraceptive pill	0.7	0.8	1.6	0.3	-1.1	0.4	1.2
Hearing aid user	1.7	1.9	4.6	-1.4	-0.3	1.1	-2.1
Mother’s age at death	0.5	0.6	2.1	0.3	0.3	1.5	-0.3
Financial situation satisfaction	0.3	0.3	1.0	-0.5	1.0	0.2	-0.1
Tinnitus: Yes, now most or all of the time	2.1	2.4	4.0	-2.0	-1.2	-1.1	-1.8
Commuting to job workplace: Public transport	2.7	3.2	5.0	-2.0	-0.7	-1.9	-2.2
Eye problems/disorders: Glaucoma	1.1	1.3	3.1	0.8	-1.1	1.8	-0.4
Medication: Blood pressure	1.5	2.8	10.3	-0.0	0.9	3.2	0.4
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.5	-2.1	-1.6	0.4	-1.3
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.8	-2.2	0.4	-0.9	-1.6
High cholesterol (Self-reported)	1.5	2.6	4.0	-2.0	-1.6	-0.3	-1.9
Medication: Bendroflumethiazide	0.6	0.8	2.5	-0.9	-0.1	1.6	-0.4
Medication: Paracetamol	0.6	0.9	3.2	0.4	1.8	-0.2	-0.0
Medication: Lisinopril	1.4	1.8	3.2	-1.6	-0.7	0.8	-1.8
Medication: Atorvastatin	0.2	0.2	0.7	-0.8	-0.2	-0.3	-0.2
Illnesses of father: High blood pressure	3.8	4.7	6.2	2.4	1.0	2.5	2.4
Alcohol drinker status: Never	0.4	0.5	1.2	-0.6	-1.1	0.4	-0.6
Ever smoked	0.1	0.2	0.4	-0.3	0.7	-0.4	-0.4
Basal metabolic rate	3.1	17.1	26.7	-5.2	-3.7	3.6	-3.9
Leg fat percentage (left)	1.3	4.6	8.1	-2.5	-2.8	2.1	-0.0
Arm fat-free mass (left)	3.7	18.6	29.3	-5.4	-4.1	3.8	-3.7
Number of operations (self-reported)	2.3	3.4	6.0	-2.5	-2.0	0.8	-1.7
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.0	0.5	-0.1	0.2
Irritability	0.7	1.1	4.5	0.1	-0.2	-0.1	2.1
Risk taking	0.5	0.7	1.6	0.4	0.8	-1.3	-0.7
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.2	0.3	-1.0	-1.5	0.7
Fractured/broken bones in last 5 years	0.3	0.3	0.8	0.2	0.7	-0.9	0.2
Age started oral contraceptive pill	0.9	1.1	2.9	0.5	0.0	1.7	1.0
Diastolic blood pressure, automated reading	0.8	2.4	5.9	-0.3	-1.9	2.4	0.0
Ever depressed for a whole week	1.9	2.4	4.4	-2.1	-1.7	-0.0	-1.4
Unable to work because of sickness or disability	2.5	3.3	11.5	-0.1	-3.4	1.2	0.3
Commuting to job workplace: Cycle	1.0	1.1	4.1	-0.4	-2.0	0.2	-0.5
Myopia	0.6	0.9	1.6	-0.9	-0.1	-1.1	-1.3
Vascular/heart problems diagnosed by doctor	1.7	4.8	11.4	1.9	0.6	-3.4	1.9
Cholesterol lowering medication	0.3	0.5	1.4	-0.2	0.4	1.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.5	0.1	0.7	0.1
Pain experienced in last month	0.6	0.9	1.3	-1.0	-1.0	-0.5	-1.1
Supplements: Calcium	2.3	2.6	5.8	-0.9	0.6	-2.4	-1.9
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.2	-1.0	-0.4	1.0
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.6	-1.1	-1.1	0.8	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.4	1.1	0.2	2.3	0.7
Heart disease (siblings)	0.2	0.2	0.6	-0.4	-0.8	-0.2	0.3
Alcohol drinker status: Previous	0.8	0.9	3.6	-0.3	-1.9	0.3	-0.0
Pack years of smoking	0.4	0.6	1.2	0.2	1.1	0.4	-0.9
Impedance of whole body	1.4	7.0	13.2	1.1	3.6	-3.6	0.5
Leg fat mass (left)	2.6	10.2	16.9	-4.1	-3.6	2.8	-1.7
Arm predicted mass (left)	3.6	18.2	28.1	-5.3	-3.7	4.0	-3.9