TWAS hub - TMEM39B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.037	0.0219	0.00025	0.026	0.027	0.020	NA	0.016	0.00057	0.00050	0.00240	NA	0.00610
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.053	0.0310	0.00110	0.043	0.050	0.053	NA	0.048	0.00072	0.00027	0.00017	NA	0.00035

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of live births	5.9	8.3	10.0	-3.2	-2.6
Sitting height	5.5	39.0	41.5	-6.4	-6.0
Illnesses of father: High blood pressure	5.2	6.4	7.0	2.6	2.4
Arm predicted mass (right)	4.8	24.5	26.2	-5.1	-4.8
Pulse wave reflection index	4.7	5.8	7.2	-2.7	-2.1
Arm fat-free mass (right)	4.6	23.7	25.6	-5.1	-4.7
Commuting to job workplace: Public transport	4.5	5.4	6.1	-2.5	-2.1
Had other major operations	4.3	5.3	6.9	-1.9	-2.6
Pulse wave Arterial Stiffness index	4.2	4.9	7.8	-2.8	-1.4
Arm fat-free mass (left)	4.2	21.3	23.2	-4.8	-4.4
Arm predicted mass (left)	4.1	20.6	22.2	-4.7	-4.4
Whole body fat-free mass	4.0	22.8	24.5	-5.0	-4.6
Tinnitus: Yes, now most or all of the time	4.0	4.6	5.1	-2.2	-2.0
Trunk fat-free mass	3.9	22.4	24.8	-5.0	-4.5
Trunk predicted mass	3.9	22.0	24.5	-5.0	-4.4
Basal metabolic rate	3.8	20.9	22.2	-4.7	-4.4
Whole body water mass	3.7	21.2	23.1	-4.8	-4.4
Leg fat-free mass (left)	3.6	19.3	19.7	-4.4	-4.3
Leg predicted mass (left)	3.5	18.4	18.6	-4.3	-4.3
Eye problems/disorders: None of the above	3.5	4.1	4.3	2.0	2.1
Prospective memory result	3.4	4.2	4.8	2.2	1.9
Standing height	3.4	33.5	38.4	-6.2	-5.3
Comparative height size at age 10	3.4	18.7	22.3	-4.7	-3.9
Relative age voice broke	3.3	5.0	5.3	-2.2	-2.3
Heart disease (mother)	3.3	4.0	4.2	-2.0	-2.0
Leg fat-free mass (right)	3.3	17.7	17.8	-4.2	-4.2
Leg predicted mass (right)	3.3	17.6	17.7	-4.2	-4.2
Supplements: Fish oil (including cod liver oil)	3.2	4.2	4.5	-2.1	-1.9
Maternal smoking around birth	3.1	4.4	5.7	-1.8	-2.4
Medication: Lansoprazole	3.1	3.5	3.8	-1.8	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	5.3	-2.3	-1.4
Suffer from ‘nerves’	3.0	4.7	4.8	2.1	2.2
Height	2.9	55.4	67.2	-8.2	-6.6
Breastfed as a baby	2.8	3.5	4.8	-2.2	-1.5
Pulse wave peak to peak time	2.8	3.3	5.5	2.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.8	6.0	-2.4	-2.4
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	4.8	-2.2	-2.0
Mineral and other dietary supplements	2.8	3.7	4.1	2.0	1.8
Weight	2.7	13.5	13.6	-3.7	-3.7
Illnesses of father: None of the above (group 1)	2.6	3.2	4.4	-2.1	-1.4
Pain type(s) experienced in last month: Hip pain	2.5	3.2	3.9	-1.6	-2.0
HbA1C	2.3	2.6	3.5	-1.3	-1.9
Mouth/teeth dental problems: Loose teeth	2.3	2.7	3.1	1.5	1.8
Eye problems/disorders: Cataract	2.3	2.6	2.9	-1.7	-1.5
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	3.0	-1.5	-1.7
Intelligence (Savage-Jansen 2018)	2.0	6.1	7.8	-2.8	-2.1
Fasting Glucose	2.0	2.3	3.0	-1.7	-1.3
Diabetes (mother)	2.0	2.5	3.0	-1.4	-1.7
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	2.8	-1.2	-1.7
Hair/balding pattern: Pattern 2	2.0	2.6	2.9	-1.5	-1.7
Forced vital capacity (FVC)	2.0	7.7	9.0	-2.5	-3.0
Number of self-reported non-cancer illnesses	2.0	3.4	4.2	-2.0	-1.6
Verbal and Numeric Reasoning (VNR)	1.9	4.7	6.1	-2.5	-1.8
Fluid intelligence score	1.9	3.9	5.4	-2.3	-1.6
Commuting to job workplace: Walk	1.9	2.1	2.1	1.5	1.4
Had menopause	1.8	2.3	2.4	-1.5	-1.5
Pain all over the body in last month	1.8	1.9	2.5	1.6	1.1
Number of operations (self-reported)	1.8	2.7	3.3	-1.4	-1.8
Mouth/teeth dental problems: Dentures	1.7	2.9	3.7	1.9	1.5
Asthma (self-reported)	1.7	3.3	4.2	-2.0	-1.5
Supplements: Calcium	1.7	1.8	2.6	-1.6	-1.0
Leg fat mass (left)	1.7	6.8	7.1	-2.6	-2.7
Trunk fat mass	1.6	7.0	7.1	-2.7	-2.6
Hip circumference	1.6	7.0	7.1	-2.6	-2.7
Lung cancer (father)	1.6	1.8	2.6	-1.0	-1.6
Medication: Ibuprofen	1.6	2.0	2.5	1.2	1.6
Unable to work because of sickness or disability	1.6	2.1	2.7	1.2	1.6
Bipolar Disorder (2018)	1.5	2.3	4.6	2.2	0.0
Lupus	1.5	2.3	4.2	-2.0	-0.7
Medication for hormone replacement therapy	1.5	1.6	2.2	1.5	1.0
Taking other prescription medications	1.5	2.4	2.4	-1.6	-1.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.6	-0.9	-1.6
High blood pressure (mother)	1.5	2.1	2.2	1.4	1.5
Allergy	1.5	3.5	4.9	2.2	1.5
Medication: Blood pressure	1.5	2.6	2.7	-1.6	-1.6
Whole body fat mass	1.5	6.2	6.3	-2.5	-2.5
Ever depressed for a whole week	1.5	1.9	2.3	-1.5	-1.2
Depression (Nagel 2018)	1.4	2.1	2.1	-1.4	-1.5
Rheumatoid Arthritis	1.4	1.9	3.9	-2.0	0.0
Waist circumference	1.4	5.0	5.3	-2.2	-2.3
Asthma	1.4	2.8	3.6	-1.9	-1.4
Leg fat mass (right)	1.4	5.6	5.6	-2.4	-2.4
Medication for cholesterol	1.4	2.2	3.2	-1.8	-1.1
Breast Cancer	1.3	3.1	3.3	-1.7	-1.8
Medication: Co-codamol	1.3	1.5	2.2	-1.5	-0.9
Medication: Levothyroxine sodium	1.3	2.3	2.7	-1.6	-1.4
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	2.7	-1.6	-1.6
Number of full sisters	1.3	1.6	1.9	-1.4	-1.1
Hayfever, allergic rhinitis or eczema	1.2	2.5	3.1	-1.8	-1.4
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	5.0	-1.8	-2.2
Blood clot in the leg (DVT)	1.2	1.6	2.2	1.0	1.5
Forced vital capacity (FVC), Best measure	1.2	4.5	5.9	-1.8	-2.4
Age when periods started (menarche)	1.1	2.6	3.6	1.3	1.9
Qualifications: CSEs or equivalent	1.1	1.5	2.3	1.5	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.4	-1.1	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.1	-1.4	-0.5
Qualifications: nursing, teaching	1.1	1.8	1.9	1.4	1.3
Wears glasses or contact lenses	1.1	1.3	1.6	-1.0	-1.3
Reaction Time	1.0	1.9	2.1	1.3	1.4
BMI	1.0	5.7	6.1	-2.3	-2.5
Smoking Status	1.0	2.4	2.8	-1.7	-1.4
Diabetes (father)	1.0	1.2	1.2	1.1	1.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.2	-0.3	-1.5
Neck or shoulder pain in last month	1.0	1.4	1.6	1.3	1.0
Medication: Allopurinol	1.0	1.3	1.9	-1.4	-0.9
Pain experienced in last month	1.0	1.7	3.1	-1.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.8	0.9	1.3
Hearing difficulty/problems: Yes	0.9	1.3	2.3	-1.5	-0.7
Hearing difficulty/problems with background noise	0.9	1.4	2.7	0.4	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	2.8	-1.7	-1.2
Arm fat mass (right)	0.9	3.9	4.0	-1.9	-2.0
Peak expiratory flow (PEF)	0.9	2.1	2.1	-1.4	-1.4
Medication: Lisinopril	0.9	1.1	1.4	-0.9	-1.2
Bipolar Disorder or Schizophrenia	0.8	2.0	4.0	2.0	0.0
Diabetes (self-reported)	0.8	1.3	1.6	-1.3	-1.0
Arm fat mass (left)	0.8	3.4	3.6	-1.8	-1.9
Respiratory disease	0.7	1.5	2.2	-1.5	-0.9
Hand grip strength (left)	0.7	1.9	2.3	-1.2	-1.5
Number of treatments/medications taken	0.7	1.3	1.9	-1.4	-0.8
Relative age of first facial hair	0.7	1.5	1.9	-1.0	-1.4
Systolic blood pressure, automated reading	0.7	2.1	2.3	1.5	1.4
Serious illness, injury or assault to yourself	0.7	0.8	1.4	0.4	1.2
Supplements: Glucosamine	0.7	0.9	1.0	-0.9	-1.0
Depression (self-reported)	0.7	0.9	0.9	0.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	2.9	-1.2	-1.7
Length of working week for main job	0.7	0.8	1.4	1.2	0.3
Average weekly red wine intake	0.7	1.0	1.5	0.7	1.2
Friendships satisfaction	0.7	0.8	1.0	-0.8	-1.0
Age started oral contraceptive pill	0.7	0.8	1.1	1.1	0.7
Alzheimer’s Disease (in father)	0.6	0.7	1.2	0.4	1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-1.3	0.0
Allergy or Eczema	0.6	1.7	1.9	-1.4	-1.2
Hypothyroidism (self reported)	0.6	1.4	1.4	-1.1	-1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	1.2	-0.0
Impedance of arm (right)	0.6	2.9	3.1	1.6	1.8
Alcohol intake versus 10 years previously	0.6	0.9	1.1	-1.1	-0.8
Worrier / anxious feelings	0.6	1.2	1.4	-1.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.1	0.6	1.0
Birth weight of first child	0.6	1.2	1.6	-0.9	-1.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.7	-1.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.0	1.0	0.9
Number of full brothers	0.6	0.7	1.3	1.1	0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	2.2	-0.2	-1.5
Migraine (self-reported)	0.6	0.8	0.9	-0.8	-1.0
Mean time to correctly identify matches	0.6	1.0	1.3	0.9	1.2
Mood swings	0.6	1.2	1.9	-0.6	-1.4
Major Depression (MDD)	0.5	0.6	1.2	-1.1	0.0
Schizophrenia (2014)	0.5	1.1	2.2	1.5	0.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.3	-1.1	-0.8
Severe depression (siblings)	0.5	0.6	1.0	1.0	0.4
Trunk fat percentage	0.5	2.0	2.2	-1.3	-1.5
Hand grip strength (right)	0.5	1.4	1.5	-1.2	-1.2
Stomach or abdominal pain in last month	0.5	0.6	1.1	-0.2	-1.1
Medication: Atenolol	0.5	0.7	0.7	0.8	0.9
Hair/balding pattern: Pattern 3	0.5	0.8	0.9	0.8	0.9
Noisy workplace	0.5	0.6	1.0	-0.5	-1.0
Worry too long after embarrassment	0.5	0.8	1.2	-0.7	-1.1
Chest pain or discomfort	0.5	0.8	0.9	1.0	0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.9	0.9	0.5
Ever had bowel cancer screening	0.5	0.6	0.8	-0.7	-0.9
Eye problems/disorders: Glaucoma	0.5	0.5	0.7	0.8	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	-0.6	-1.2
Coronary Artery Disease (CAD)	0.4	0.5	1.1	-1.0	0.0
Blood White Count	0.4	2.7	2.9	-1.7	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.3	-1.1	-0.9
High blood pressure	0.4	1.0	1.5	-1.2	-0.7
Impedance of arm (left)	0.4	2.0	2.3	1.3	1.5
Hair/balding pattern: Pattern 4	0.4	0.9	1.5	1.2	0.5
Leg pain on walking	0.4	0.6	0.7	-0.8	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.5	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.9	-0.2	-0.9
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.5	-1.0
Average weekly champagne plus white wine intake	0.4	0.5	1.0	-1.0	-0.1
Fractured/broken bones in last 5 years	0.4	0.6	1.1	0.0	1.1
Cholesterol lowering medication	0.4	0.6	1.0	0.4	1.0
Worry (Nagel 2018)	0.3	0.6	1.0	1.0	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.2	0.9
Prostate Cancer	0.3	0.4	0.5	0.7	0.6
Mean Putamen Volume	0.3	0.4	0.7	0.9	-0.1
Cardiovascular Disease	0.3	1.0	1.2	-1.1	-1.0
Tanning	0.3	3.4	5.2	1.3	2.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	0.5	0.6
Vitamin and mineral supplements	0.3	0.4	0.5	0.7	0.5
Body mass index (BMI)	0.3	1.4	1.9	-0.9	-1.4
Alcohol usually taken with meals	0.3	0.5	0.9	0.4	0.9
Qualifications: None of the above	0.3	0.7	1.5	1.2	0.1
Father’s age at death	0.3	0.4	0.4	-0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.1	-0.1	-1.1
Pulse rate	0.3	0.5	0.9	0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	-0.0	1.1
Tense / ‘highly strung’	0.3	0.5	0.7	0.9	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.4	-0.5	-0.6
Loud music exposure frequency	0.3	0.3	0.6	-0.8	0.2
Gout (self-reported)	0.3	0.4	0.7	-0.8	0.1
Body fat percentage	0.3	1.1	1.2	-1.0	-1.1
Shortness of breath walking on level ground	0.3	0.4	0.7	0.2	0.9
Age at last live birth	0.3	0.5	0.9	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	-0.4	-0.7
Knee pain experienced in last month	0.3	0.5	0.9	0.9	0.2
Medication: Gliclazide	0.3	0.4	0.7	0.8	0.1
Miserableness	0.3	0.4	0.9	-0.1	-0.9
Medication: Bendroflumethiazide	0.3	0.4	0.6	-0.4	-0.8
Medication: Paracetamol	0.3	0.4	0.8	-0.1	0.9
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.1	1.1	0.6
Impedance of whole body	0.3	1.4	1.7	1.0	1.3
Schizophrenia (2018)	0.2	0.4	0.7	0.8	0.0
Crohns Disease (2017)	0.2	0.4	0.9	0.9	0.1
Crohns Disease (2012)	0.2	0.3	0.6	-0.8	0.0
LDL Cholesterol	0.2	0.3	0.5	0.7	0.0
Blood Eosinophil Count	0.2	1.5	1.7	-1.1	-1.3
Blood Platelet Count	0.2	2.7	3.0	-1.5	-1.7
Blood Red Count	0.2	2.1	2.2	-1.5	-1.4
Waist Hip Ratio (WHR)	0.2	1.0	1.1	-1.1	-1.0
Systolic Blood Pressure	0.2	1.2	1.6	0.9	1.3
Chronotype (morning person)	0.2	0.5	0.7	0.5	0.8
Average weekly spirits intake	0.2	0.3	0.5	0.1	0.7
Angina	0.2	0.3	0.6	0.8	0.0
Impedance of leg (right)	0.2	1.1	1.4	0.8	1.2
Current tobacco smoking	0.2	0.4	0.7	-0.9	-0.3
Average weekly fortified wine intake	0.2	0.2	0.3	-0.3	-0.5
Fed-up feelings	0.2	0.4	0.6	-0.5	-0.8
Impedance of leg (left)	0.2	0.9	1.2	0.8	1.1
Financial difficulties in last 2 years	0.2	0.3	0.4	0.6	0.5
Medication: Ramipril	0.2	0.2	0.4	0.0	0.7
Medication: Simvastatin	0.2	0.3	0.4	-0.4	0.6
Falls in the last year	0.2	0.3	0.5	0.7	-0.2
Illnesses of mother	0.2	0.2	0.3	0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.7	-0.3
High blood pressure (siblings)	0.2	0.3	0.5	0.1	0.7
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.7	0.1
Number of children fathered	0.2	0.3	0.4	0.3	0.7
Qualifications: College or University degree	0.2	0.7	1.4	0.2	1.2
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.5	0.4
Angina (self-reported)	0.2	0.3	0.6	0.8	-0.1
Medication: Omeprazole	0.2	0.3	0.5	0.2	0.7
Pulse rate, automated reading	0.2	0.7	0.7	-0.8	-0.8
Alcohol intake frequency.	0.2	0.5	0.7	-0.5	-0.8
Hypertension (Self-reported)	0.2	0.6	0.9	-0.9	-0.6
Diabetes diagnosed by doctor	0.2	0.3	0.4	-0.6	-0.5
Back pain experienced in last month	0.2	0.3	0.5	0.7	-0.3
Smoking status: Current	0.2	0.3	0.5	-0.7	-0.3
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.4	0.5
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.8	-0.3
Medication: Atorvastatin	0.2	0.3	0.4	0.6	-0.4
Leg fat percentage (left)	0.2	0.8	1.1	-0.7	-1.0
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.1	-0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.2	0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	0.7	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.2	0.4	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.3	-0.4
Ulcerative Colitis	0.1	0.1	0.3	-0.5	0.0
Lung FVC	0.1	0.3	0.4	-0.4	-0.7
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.4	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.3	-0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.5	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.4	0.3
Medication: Metformin	0.1	0.2	0.2	-0.3	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.0	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.3	-0.5
Multivitamins +/- minerals	0.1	0.2	0.3	-0.5	-0.2
Number of incorrect matches in round	0.1	0.1	0.1	0.4	-0.3
Nervous feelings	0.1	0.1	0.2	0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.3	-0.2
Heart attack	0.1	0.1	0.1	-0.3	-0.2
Neuroticism score	0.1	0.1	0.3	0.0	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.5	-0.1
Medication: Paracetamol	0.1	0.2	0.5	-0.7	0.1
Headache pain in last month	0.1	0.2	0.3	-0.6	-0.4
Medication: Amlodipine	0.1	0.1	0.2	-0.3	0.4
Leg fat percentage (right)	0.1	0.5	0.6	-0.6	-0.8
Comparative body size at age 10	0.1	0.2	0.4	-0.2	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.4	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.2	0.3
Overall health rating	0.1	0.2	0.4	0.7	0.0
Had major operations	0.1	0.1	0.2	0.0	0.5
Medication: Aspirin	0.1	0.2	0.3	-0.5	0.3
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	-0.2
Smoking status: Previous	0.1	0.2	0.3	-0.5	-0.4
Loneliness, isolation	0.1	0.1	0.2	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.1	0.4
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	-0.4
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.2	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	0.5
Medication: Aspirin	0.1	0.2	0.2	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.3	-0.6
Hearing aid user	0.1	0.1	0.2	-0.5	-0.0
Mother’s age at death	0.1	0.2	0.3	-0.2	-0.5
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.2
Ever smoked	0.1	0.1	0.2	0.4	0.1
Diastolic blood pressure, automated reading	0.1	0.5	0.8	0.9	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.3	-0.4
Myopia	0.1	0.1	0.2	-0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.3	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.2	0.0
Ovarian Cancer	0.0	0.0	0.0	-0.1	0.1
Age at First Birth	0.0	0.0	0.0	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.0	0.2	0.0
Triglycerides	0.0	0.0	0.1	-0.3	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.1	0.0
Heel T-Score	0.0	0.0	0.1	-0.2	0.3
Lung FEV1/FVC ratio	0.0	0.0	0.0	-0.0	-0.2
Neuroticism	0.0	0.1	0.1	0.3	-0.2
Hair Pigment	0.0	0.3	0.5	0.7	0.4
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.1	0.2
Supplements: Zinc	0.0	0.0	0.0	-0.0	0.1
Pack years adult smoking proportion	0.0	0.0	0.0	0.1	-0.2
Past tobacco smoking	0.0	0.1	0.1	0.2	0.2
Mouth/teeth dental problems	0.0	0.0	0.1	-0.2	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	-0.2	0.2
Illnesses of siblings	0.0	0.1	0.1	0.4	0.0
Arm fat percentage (right)	0.0	0.1	0.1	-0.1	-0.3
Time employed in main current job	0.0	0.0	0.0	0.2	0.1
Happiness	0.0	0.0	0.0	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	-0.2	0.2
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.2	-0.2
Glaucoma (self-reported)	0.0	0.0	0.0	-0.1	-0.2
Birth weight	0.0	0.1	0.1	0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.2	-0.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.2	0.2
Age at first live birth	0.0	0.1	0.1	-0.3	-0.0
Health satisfaction	0.0	0.0	0.1	0.1	0.3
Family relationship satisfaction	0.0	0.0	0.1	0.2	0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.2	0.2
Arm fat percentage (left)	0.0	0.2	0.2	-0.3	-0.5
Long-standing illness, disability or infirmity	0.0	0.0	0.0	-0.2	-0.1
Guilty feelings	0.0	0.1	0.1	0.3	-0.2
Financial situation satisfaction	0.0	0.0	0.0	-0.0	-0.0
Medication: Blood pressure	0.0	0.0	0.0	0.2	0.2
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1
Irritability	0.0	0.1	0.1	0.2	-0.3
Risk taking	0.0	0.0	0.1	0.1	0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.0	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	0.0
Heart disease (siblings)	0.0	0.0	0.0	-0.2	0.2
Pack years of smoking	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

TMEM39B

Models

Trait associations