Hub : Genes

ARSB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3610 0.0390 0.0e+00 0.252 0.333 0.368 0.341 0.366 2.0e-30 1.1e-41 5.5e-47 7.7e-43 1.3e-46
2 GTEx Artery Tibial 0.1704 0.0665 3.0e-03 0.010 NA 0.022 NA 0.028 5.1e-02 NA 7.0e-03 NA 2.9e-03
3 GTEx Brain Cortex 0.4030 0.1110 1.6e-03 0.155 NA 0.136 NA 0.148 4.6e-05 NA 1.4e-04 NA 7.2e-05
4 GTEx Brain Hippocampus 0.3962 0.1122 5.6e-04 0.029 NA 0.076 NA 0.089 7.1e-02 NA 7.7e-03 NA 4.2e-03
5 GTEx Breast Mammary Tissue (Male) 0.2422 0.1043 9.6e-03 0.063 NA 0.000 NA 0.049 1.4e-02 NA 3.3e-01 NA 2.8e-02
6 GTEx Cells Transformed fibroblasts 0.3200 0.0600 3.1e-09 0.185 NA 0.183 NA 0.209 8.0e-14 NA 9.7e-14 NA 1.3e-15
7 GTEx Liver 0.4460 0.1110 3.1e-04 0.139 NA 0.156 NA 0.171 1.1e-04 NA 4.1e-05 NA 1.7e-05
8 GTEx Muscle Skeletal 0.0772 0.0300 1.8e-03 -0.001 NA 0.020 NA 0.016 4.6e-01 NA 4.2e-03 NA 9.3e-03
9 GTEx Nerve Tibial 0.1699 0.0731 4.9e-03 0.038 NA 0.003 NA 0.018 1.1e-03 NA 2.0e-01 NA 1.9e-02
10 GTEx Skin Sun Exposed Lower leg 0.1150 0.0400 5.7e-04 0.057 NA 0.075 NA 0.072 1.7e-05 NA 8.7e-07 NA 1.4e-06
11 GTEx Stomach 0.1900 0.0610 6.1e-04 0.006 NA 0.027 NA 0.038 1.6e-01 NA 1.9e-02 NA 6.6e-03
12 GTEx Testis 0.2770 0.0920 3.5e-03 0.125 NA 0.096 NA 0.132 3.7e-06 NA 5.0e-05 NA 1.8e-06
13 NTR Blood 0.0640 0.0179 9.7e-08 0.018 0.032 0.026 0.033 0.017 9.6e-07 1.1e-10 6.6e-09 7.8e-11 1.9e-06
14 ROSMAP Brain Pre-frontal Cortex 0.2607 0.0416 0.0e+00 0.165 0.189 0.189 0.210 0.195 1.1e-20 1.1e-23 9.3e-24 1.8e-26 1.5e-24
15 TCGA Breast Invasive Carcinoma 0.0904 0.0252 1.9e-09 0.023 0.050 0.056 NA 0.045 1.0e-05 2.0e-10 1.1e-11 NA 1.4e-09
16 TCGA Colon Adenocarcinoma 0.0830 0.0400 9.4e-03 0.024 0.021 0.011 NA 0.019 1.4e-02 2.0e-02 7.5e-02 NA 2.6e-02
17 TCGA Head and Neck Squamous Cell Carcinoma 0.0896 0.0378 2.7e-03 0.026 0.014 0.014 NA 0.031 5.2e-04 9.8e-03 8.5e-03 NA 2.0e-04
18 TCGA Kidney Renal Clear Cell Carcinoma 0.1158 0.0307 1.3e-10 0.065 0.089 0.086 NA 0.087 8.8e-08 3.0e-10 6.4e-10 NA 5.7e-10
19 TCGA Kidney Renal Papillary Cell Carcinoma 0.2250 0.0640 4.4e-06 0.027 0.070 0.069 NA 0.069 1.1e-02 7.7e-05 8.5e-05 NA 8.6e-05
20 TCGA Brain Lower Grade Glioma 0.0483 0.0235 5.3e-03 0.009 0.026 0.008 NA 0.010 2.6e-02 5.5e-04 3.5e-02 NA 2.1e-02
21 TCGA Liver Hepatocellular Carcinoma 0.2150 0.0970 3.3e-03 -0.001 0.049 0.002 NA 0.005 3.7e-01 2.4e-03 2.5e-01 NA 1.8e-01
22 TCGA Lung Adenocarcinoma 0.0850 0.0295 4.2e-05 0.020 0.038 0.025 NA 0.016 1.8e-03 2.6e-05 5.8e-04 NA 4.5e-03
23 TCGA Lung Squamous Cell Carcinoma 0.0715 0.0277 1.4e-04 0.007 0.036 0.008 NA 0.014 4.4e-02 5.2e-05 3.3e-02 NA 9.8e-03
24 TCGA Thyroid Carcinoma 0.0670 0.0290 1.6e-03 -0.001 0.025 -0.002 NA -0.002 4.4e-01 1.4e-03 5.7e-01 NA 6.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bipolar Disorder (2018) 1.9 3.0 8.6 -1.9 1.4 -1.9 -1.8 2.2 2.9 -1.7 -0.4 1.9 1.8 1.8 0.5 1.1 -1.7 1.8 1.4 -0.2 1.9 1.9 -1.8 -2.1 1.9 1.4 2.0
Bipolar Disorder or Schizophrenia 1.0 2.4 9.6 -0.5 0.9 -0.6 -0.8 1.6 1.2 -1.8 1.5 1.0 1.1 3.1 0.6 -0.0 -0.5 1.8 1.6 0.8 2.0 2.2 -1.3 -2.1 1.9 1.9 2.5
Depressed Affect (Nagel 2018) 0.4 0.8 5.2 1.0 0.5 0.2 -0.9 -0.5 1.5 -0.6 -2.3 0.3 0.2 -1.3 0.7 -0.3 0.5 0.4 1.0 1.7 -0.0 1.1 1.0 -0.6 -0.2 0.1 0.6
Depression (Nagel 2018) 0.4 0.6 5.1 0.0 -0.1 -0.1 -1.7 -0.8 1.0 -0.3 -1.4 -0.4 -0.5 -2.3 0.3 -0.6 -0.1 -0.6 0.4 1.0 -0.4 0.0 0.5 -0.2 -0.5 -0.3 -0.7
Intelligence (Savage-Jansen 2018) 0.3 1.1 4.1 1.7 0.5 1.2 -1.1 -1.6 0.5 0.0 -1.3 -0.8 -0.8 -1.1 0.5 -0.6 2.0 -0.6 1.1 1.9 0.2 -0.1 1.2 -0.0 -0.4 0.8 0.0
Neuroticism (Nagel 2018) 0.2 0.5 2.0 0.9 0.4 0.9 -0.5 -0.7 0.9 -0.8 -1.1 -0.3 -0.2 -1.0 -0.2 -0.8 0.8 -0.5 -0.0 0.8 -0.5 0.6 0.6 -1.4 -0.2 -0.2 1.1
Schizophrenia (2018) 0.6 1.1 6.6 0.8 0.1 0.7 0.5 0.2 -0.8 -0.9 2.2 -0.3 0.3 2.6 0.3 -0.9 0.7 0.8 1.0 1.2 1.0 1.2 -0.2 -0.8 0.9 1.3 1.6
Schizophrenia vs Biploar Disorder 0.8 1.1 5.7 0.9 -0.2 1.0 1.0 0.2 -1.3 -0.2 2.0 -0.5 0.1 0.3 0.5 -0.0 1.0 0.7 0.3 0.2 1.8 1.5 -0.9 -0.4 1.2 0.8 2.4
Worry (Nagel 2018) 0.2 0.4 4.8 0.5 0.0 0.7 -0.4 -0.6 0.2 -0.6 0.9 -0.6 -0.5 0.1 -0.6 -0.7 0.7 -0.4 -0.3 -0.2 -0.3 -0.1 -0.0 -2.2 0.5 0.2 0.8
Alzheimer’s Disease (in mother) 1.1 1.2 4.4 0.1 -1.2 0.9 -0.5 -0.5 -0.7 1.1 -0.8 -1.0 -1.2 -1.3 -1.0 -1.0 -0.1 -0.8 -2.0 -2.1 -1.9 -1.3 -0.4 0.3 -0.5 -1.6 -0.9
Alzheimer’s Disease (in father) 0.6 0.7 5.5 -0.2 -0.2 -0.4 -0.8 0.4 2.4 -1.0 -1.0 1.1 0.7 -1.2 -0.0 0.7 -0.7 0.1 0.7 0.3 0.6 0.3 -0.3 -1.6 0.1 0.1 -0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 2.9 0.1 -0.8 0.6 -0.5 -0.0 0.7 0.0 -1.3 -0.3 -0.4 -1.6 -0.9 -0.8 -0.4 -0.5 -1.1 -1.7 -1.2 -0.8 -0.2 -0.7 -0.5 -1.4 -0.8
Crohns Disease (2017) 0.6 1.4 5.9 -1.6 0.9 -1.8 0.4 1.2 1.0 -0.6 -1.6 0.3 1.0 0.2 0.6 0.2 -2.4 2.2 1.5 -0.4 0.6 1.4 -0.8 -0.2 1.3 1.1 1.4
Irritable Bowel Disease (IBD) 0.6 1.3 4.6 -1.6 0.7 -1.6 0.4 1.6 0.8 -1.3 0.2 1.1 1.2 1.3 0.2 -0.2 -2.0 1.7 1.1 -0.6 0.8 2.1 -0.7 -0.4 0.7 1.0 1.1
Ulcerative Colitis (UC) 0.7 1.2 5.3 -1.2 0.7 -1.2 -0.1 1.8 0.8 -1.3 1.5 1.7 1.2 1.5 -0.1 -0.1 -1.2 1.0 0.6 -0.5 1.1 2.3 -0.6 -0.6 0.4 0.6 1.1
Major Depression (MDD) 1.0 1.2 4.5 0.9 -1.3 0.4 -1.4 -1.1 0.7 0.4 -1.7 0.6 0.1 -1.7 -0.5 0.4 -0.0 -1.2 -0.2 0.7 -1.1 -0.8 2.1 1.2 -0.9 -1.3 -2.0
Reaction Time 0.5 0.9 3.7 -0.3 1.3 -0.7 0.9 1.3 0.5 -1.8 -0.8 1.1 1.3 -0.1 -1.0 -0.1 -0.2 -0.3 1.0 -0.3 0.6 0.3 0.1 -1.9 -0.6 1.7 0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.6 4.0 1.3 0.6 1.0 -0.5 0.0 0.4 -0.8 0.2 -1.2 0.2 0.3 -0.5 -0.3 2.0 -0.5 0.6 0.7 0.1 0.4 1.5 -0.2 -0.4 0.8 -0.1
Breast Cancer 0.1 0.2 0.9 0.0 0.8 -0.3 0.0 -0.2 1.0 -0.1 -0.4 -0.2 -0.3 -0.0 -0.5 0.1 0.0 -0.6 0.1 -0.3 0.3 -0.7 0.3 0.5 -0.6 -0.5 -0.5
Ovarian Cancer 0.5 0.7 3.2 -0.9 -0.9 0.1 0.1 -0.4 -1.8 0.6 0.3 -0.5 -1.1 0.7 1.0 -0.7 -0.4 0.6 -0.8 -0.0 -0.4 0.5 -1.5 0.1 1.5 -0.2 1.4
Prostate Cancer 0.4 0.6 5.7 1.1 1.0 0.4 0.1 -0.4 0.9 -0.2 -0.5 0.7 0.3 -2.4 -0.7 -0.2 0.6 -0.3 0.5 0.3 0.2 -0.9 0.8 -1.3 0.1 0.3 -0.3
Age at First Birth 0.8 1.1 5.0 1.3 -0.2 1.1 -0.4 -0.6 -1.0 0.7 -0.2 0.1 -0.2 -0.5 -1.6 -0.2 1.0 -2.2 -0.9 -0.6 -0.4 -0.9 1.0 1.3 -2.1 -1.0 -1.6
Bipolar Disorder (2011) 2.0 1.9 6.7 -0.2 1.0 -1.0 -2.3 1.5 2.6 -0.6 0.2 1.8 1.5 0.2 0.5 1.4 -0.4 1.3 2.2 1.5 1.9 2.3 0.7 -0.2 1.1 0.8 1.4
Body Mass Index (BMI) (2010) 0.5 0.7 2.3 0.1 -0.7 0.2 0.2 -1.2 0.0 1.0 0.8 -1.4 -1.3 -1.0 -0.5 -0.3 0.4 -0.6 -0.9 -1.1 -0.9 -1.5 -0.5 -0.2 -0.4 -0.9 -0.2
Coronary Artery Disease (CAD) 0.7 0.8 2.9 -1.2 -0.5 -0.5 0.3 1.1 -1.5 -1.4 1.4 -0.4 0.4 1.7 0.1 -0.2 -0.8 0.9 -0.1 -0.4 0.3 -0.0 -1.2 -1.0 1.0 1.3 0.3
Crohns Disease (2012) 0.5 0.8 5.8 -1.6 -0.1 -1.4 0.5 -0.2 0.2 0.2 -1.4 -1.1 -0.6 -0.5 0.3 0.3 -2.4 1.1 0.6 -0.9 0.0 0.1 -0.9 -0.2 0.7 0.8 0.5
Mean Putamen Volume 0.6 0.7 2.5 0.8 0.8 0.6 0.9 0.5 1.3 1.0 -0.6 0.0 0.2 0.9 1.0 1.6 0.3 0.6 0.9 0.7 -0.2 -0.4 1.3 1.3 -0.1 0.8 -1.2
Fasting Glucose 2.0 2.4 11.9 0.1 2.6 -0.8 -2.9 1.5 3.4 -0.5 -1.2 1.9 2.0 -1.9 -0.3 0.8 -0.1 0.6 2.1 0.3 1.9 1.6 0.7 0.1 -0.0 0.7 1.0
HbA1C 0.3 0.3 2.7 0.3 0.3 0.8 1.6 -0.3 -0.9 0.6 -0.3 0.5 -0.6 0.6 -0.3 0.8 0.4 -0.8 -0.3 0.0 -0.2 -0.2 -0.1 0.4 0.2 0.4 0.2
HDL Cholesterol 0.3 0.5 3.0 0.5 0.2 0.8 0.2 0.4 -1.5 -0.6 1.4 0.9 0.4 1.7 -0.2 -0.2 1.2 -0.2 0.2 0.1 0.2 0.1 0.2 -0.1 -0.3 0.4 -0.1
LDL Cholesterol 0.9 1.5 4.8 -1.0 0.2 -1.1 -0.9 0.7 -0.1 -1.4 1.0 0.8 0.5 2.0 0.8 -0.5 -0.5 0.8 0.8 1.0 1.8 1.3 -1.9 -2.1 1.0 1.4 2.2
Lupus 1.1 1.7 6.9 1.0 1.7 0.6 0.4 1.6 0.0 -1.0 -0.3 1.3 1.7 0.5 0.1 1.2 0.8 0.5 2.2 1.0 2.0 1.6 -0.3 -0.4 0.9 2.6 2.3
Neuroticism (2016) 1.4 2.0 7.0 1.8 0.9 0.9 -0.6 -0.2 1.7 -0.4 -1.1 1.1 0.5 -2.6 0.6 1.7 1.7 -0.3 2.1 2.2 0.8 2.0 2.3 -0.3 0.3 1.3 1.2
Primary Biliary Cirrhosis 1.1 1.6 5.1 -0.4 1.0 -0.9 -0.8 1.9 0.4 -2.3 0.1 1.9 1.9 -0.3 -1.2 1.8 -0.2 -0.4 1.7 -0.3 2.1 1.2 -0.4 -1.6 0.4 1.5 0.7
Rheumatoid Arthritis 0.9 1.2 3.0 -0.6 -1.7 -0.0 -0.4 -1.7 -0.4 0.9 -1.6 -1.2 -1.4 -1.4 0.3 1.1 -1.4 -1.0 -0.9 0.3 -1.3 -1.1 0.3 1.1 -0.8 -1.7 -1.3
Schizophrenia (2014) 0.7 1.5 7.7 0.4 0.1 0.3 0.5 0.5 -0.2 -0.6 1.6 -0.2 0.3 2.8 0.6 -0.7 0.2 1.2 1.1 0.9 1.9 1.7 -1.0 -1.0 1.5 1.6 2.5
Triglycerides 0.8 1.3 2.7 -1.2 1.3 -1.6 1.0 0.7 0.9 -0.5 -0.7 -0.3 0.6 -0.7 1.2 1.1 -1.6 1.6 1.2 1.1 1.2 1.0 -1.0 -0.8 1.3 1.5 1.5
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.8 0.3 1.7 0.7 0.8 1.2 1.6 -1.3 -1.4 -0.1 1.3 1.0 -0.9 0.1 -0.1 -0.2 -0.3 -0.7 -0.8 -0.1 1.5 -0.8 -1.2 0.1 -0.7
Ulcerative Colitis 0.5 0.8 2.2 -1.1 0.7 -0.7 -1.0 1.0 1.0 -1.5 0.7 0.3 0.6 1.3 -0.5 -1.5 -1.2 0.1 0.3 -0.4 0.1 1.4 -0.4 -1.3 -0.1 0.9 0.6
Blood Eosinophil Count 0.3 2.1 6.0 -1.4 -1.4 0.9 1.8 -0.8 -2.4 0.6 -0.7 -2.1 -1.7 0.2 -0.4 -0.6 -1.6 -0.5 -2.4 -2.0 -2.3 -2.1 -1.7 -0.2 -1.0 -0.9 -0.8
Blood Platelet Count 0.8 9.3 106.1 -2.0 0.5 -1.7 10.3 0.8 0.2 -0.9 2.1 0.3 1.0 8.4 -0.3 3.9 -3.3 0.0 1.0 -0.1 1.3 0.3 -0.4 -0.9 0.3 1.0 1.1
Blood Red Count 0.1 1.4 5.3 -1.2 -0.8 -0.4 0.3 -0.7 -1.7 1.7 0.9 -2.0 -1.4 0.3 -0.2 -0.4 -1.1 -1.0 -2.0 -1.2 -2.3 -1.5 -0.3 0.9 -0.1 -1.1 -0.6
Blood White Count 0.6 4.6 11.5 -1.2 -1.6 -0.6 0.3 -2.6 -0.9 3.4 -2.2 -1.2 -2.8 -2.9 -0.4 -1.2 -1.5 -2.9 -2.6 -0.9 -3.4 -2.9 0.9 1.6 -2.4 -3.0 -2.5
Heel T-Score 0.7 5.5 33.2 -0.7 1.2 -2.9 -0.9 0.2 3.2 -1.0 -2.2 1.6 1.4 -1.5 3.9 1.8 -1.6 2.7 3.8 5.8 1.9 2.6 2.6 0.7 1.9 0.9 0.9
BMI 0.6 3.2 8.4 -2.3 -2.5 -1.8 0.1 -2.9 -0.4 2.6 -1.5 -2.0 -2.9 -2.7 0.9 0.5 -2.6 -1.1 -1.6 0.8 -1.7 -1.2 -0.9 1.0 -0.2 -2.5 -0.9
Height 0.9 18.2 48.8 4.7 -3.0 5.9 1.0 -3.1 -3.4 4.1 -4.7 -3.3 -3.1 -7.0 -2.7 -1.4 3.7 -4.0 -4.6 -3.0 -7.0 -5.3 3.3 4.8 -4.8 -3.0 -5.5
Waist Hip Ratio (WHR) 0.2 0.9 4.8 0.1 0.1 0.8 1.0 0.7 -0.2 0.5 -0.2 -0.5 0.2 0.7 -1.4 -0.7 0.3 -1.3 -1.8 -2.2 -1.0 -1.3 -1.2 0.0 -1.6 -0.7 0.2
Systolic Blood Pressure 0.6 2.9 30.2 1.0 1.0 -0.2 2.1 1.8 1.1 -0.7 2.3 5.5 2.4 1.4 -1.4 2.0 1.1 -0.7 0.3 -0.7 1.9 1.1 0.2 -0.7 -0.2 -1.0 0.8
Smoking Status 1.1 2.7 9.4 0.6 -0.8 1.2 1.5 -1.5 -0.9 1.6 1.0 -0.5 -1.0 -0.0 -2.2 0.6 0.3 -2.5 -1.9 -1.7 -2.4 -1.9 1.4 1.1 -2.7 -2.3 -3.1
Allergy or Eczema 0.2 0.6 2.4 0.1 -0.2 -0.2 -0.6 -1.4 0.1 0.5 -1.5 -0.9 -0.5 -0.2 1.0 0.1 -0.8 0.3 0.8 1.6 -0.5 -0.1 1.3 0.4 0.0 0.3 -1.0
Cardiovascular Disease 0.3 1.0 6.3 -0.7 -1.0 -1.0 0.0 -0.5 -0.8 0.9 -0.8 2.5 -0.2 -2.2 -0.1 0.4 -0.7 -0.6 -0.9 -0.5 0.1 0.4 -1.4 0.1 -0.2 -1.6 0.9
Hypothyroidism (self reported) 0.5 1.1 7.5 -0.9 -2.7 -0.4 -0.4 -1.8 -0.6 0.8 0.5 -1.3 -1.9 0.8 0.7 -1.0 -1.0 -0.8 -0.3 0.2 -0.8 -1.1 -0.6 -0.3 -0.0 -1.1 -1.1
Respiratory disease 1.3 3.0 14.6 -0.5 -2.2 -0.3 -3.8 -2.5 0.9 2.4 -1.8 -1.4 -2.4 -1.7 0.2 -2.2 -0.8 -1.8 -1.0 0.2 -2.0 -1.4 0.2 -0.2 -1.3 -1.4 -2.3
Type 2 Diabetes (T2D) (2018) 2.4 4.5 13.1 1.3 -2.0 1.7 -2.0 -2.1 0.4 2.0 -1.7 -1.1 -1.9 -1.2 -1.9 -1.9 0.9 -3.2 -2.7 -1.5 -2.6 -2.1 1.2 1.5 -3.6 -3.5 -3.0
Lung FEV1/FVC ratio 1.2 5.9 16.5 -2.9 0.2 -3.1 3.0 1.5 0.5 -0.1 0.8 1.3 0.3 1.9 4.0 3.4 -3.7 3.7 1.9 2.2 2.4 1.9 -1.8 0.7 4.1 2.0 2.9
Lung FVC 0.7 3.5 9.9 -2.6 0.4 -2.7 1.5 0.9 -1.5 -0.5 1.3 -1.5 0.1 1.7 3.1 0.7 -2.4 2.9 0.8 1.8 2.2 1.2 -2.2 0.0 2.8 1.1 3.0
Neuroticism 0.4 0.9 2.8 1.0 1.1 0.3 -1.4 -0.9 1.6 -0.6 -0.5 0.4 0.4 -1.7 -0.7 -0.1 1.1 -1.1 0.7 0.8 0.4 0.8 1.2 -1.6 -0.5 -0.5 0.8
Chronotype (morning person) 0.2 0.4 1.4 -1.2 -0.2 -0.6 -0.4 -0.8 -0.8 0.0 -0.4 -0.9 -0.9 0.5 0.7 -0.3 -0.9 0.8 -0.4 0.2 -0.1 -0.4 -1.2 -0.3 0.6 0.5 -0.7
Hair Pigment 0.1 2.0 10.4 1.1 -0.9 1.4 0.3 -0.7 -0.2 0.8 -0.1 -0.1 -0.3 1.0 -1.9 0.2 0.6 -2.8 -1.0 -1.6 -1.5 -2.0 1.2 0.9 -3.2 -1.5 -2.5
Tanning 0.0 0.5 2.9 -0.3 0.7 -0.6 1.7 1.1 0.1 -0.5 0.1 1.1 0.9 -1.4 -0.7 0.4 -0.2 0.8 0.0 -0.7 0.4 -0.2 0.3 -0.7 0.3 -0.2 0.2
Hand grip strength (left) 0.6 1.7 6.1 -0.9 -1.2 -1.2 0.6 -1.5 -1.6 2.0 -0.9 -1.3 -2.0 -0.5 1.6 1.4 -1.2 0.3 -0.5 0.8 -1.2 -1.3 0.9 2.5 0.5 -1.2 -1.2
Number of treatments/medications taken 0.9 1.6 4.7 0.7 -1.0 0.7 -1.6 -1.8 -0.6 1.8 -1.7 0.5 -1.3 -2.0 -0.6 -1.3 0.9 -2.2 -1.1 -0.3 -1.0 -0.8 0.0 0.8 -1.9 -2.0 -0.7
Average weekly spirits intake 0.4 0.5 2.2 0.0 -0.2 0.0 -1.4 -0.3 0.1 0.9 -1.5 -0.1 -0.3 -1.5 -0.3 -0.8 -0.1 -0.5 -0.4 -0.4 -0.8 -0.3 0.2 0.9 -0.6 -1.2 -0.9
Sensitivity / hurt feelings 1.2 2.1 7.1 2.0 2.7 1.4 0.5 1.0 1.4 -1.4 -0.5 1.8 1.8 -1.0 -1.6 1.8 2.5 -1.3 0.9 0.4 0.9 1.2 2.2 -0.5 -1.0 0.3 0.6
Frequency of depressed mood in last 2 weeks 1.1 1.5 7.5 1.0 -0.8 0.8 -1.7 -1.4 1.0 0.7 -1.7 0.1 -1.1 -2.7 -0.3 -0.6 0.7 -1.8 -0.3 0.2 -1.0 -0.7 1.3 0.0 -1.7 -1.7 -1.3
Hearing difficulty/problems: Yes 0.5 0.7 2.7 -0.7 -0.5 -0.1 0.1 0.8 0.5 -1.1 -0.7 -0.2 0.5 0.9 -1.5 -0.6 -0.7 -1.6 -0.5 -1.2 -1.0 -0.5 -0.6 -1.6 -0.9 0.3 -0.5
Relative age of first facial hair 0.5 1.1 3.1 0.8 1.1 1.4 -0.9 1.1 -1.6 -1.2 0.6 -0.4 0.5 1.5 -1.6 -1.8 1.7 -0.0 -0.5 -1.6 -0.4 -0.3 0.0 -1.0 -0.8 0.4 0.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 3.4 -0.3 0.3 0.5 -0.1 -0.6 -0.0 -0.4 -1.9 0.1 -0.6 -1.1 -0.9 -1.8 0.1 -1.3 -0.5 -0.8 -0.2 0.1 -0.9 -1.7 -1.1 -0.7 0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.8 -0.6 0.4 -0.4 -1.0 -0.4 1.5 0.4 -0.6 -1.0 -0.6 1.7 -0.1 -1.1 -1.1 -0.2 -0.5 -0.8 0.1 -0.9 -1.0 -1.4 -0.4 0.3 -0.6
Ever had hysterectomy (womb removed) 0.6 0.7 2.3 -1.1 -0.3 -0.9 -1.5 -1.5 0.7 0.8 -0.8 -1.1 -1.2 0.4 -0.2 -0.6 -0.9 -1.4 -0.8 -0.2 -0.3 -0.7 -1.0 0.1 -0.7 -0.7 0.0
Systolic blood pressure, automated reading 0.4 1.2 9.5 -0.6 1.1 -1.2 1.0 0.8 0.6 -0.6 1.2 3.1 0.9 1.0 -1.0 1.3 -0.2 -0.9 -0.0 -0.6 1.4 0.5 -0.9 -1.4 -0.1 -0.7 0.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 4.7 -1.9 -1.6 -1.8 -1.6 -0.0 2.2 -0.1 1.1 0.1 -0.1 0.0 0.6 -0.5 -1.5 0.4 -0.6 0.1 -0.0 0.8 -1.0 -1.0 0.1 -1.8 -0.1
Angina 0.9 1.2 3.9 -1.9 -0.7 -1.1 0.6 -0.1 -0.2 0.7 -0.5 -0.2 -0.6 1.6 -0.4 -0.7 -2.0 -0.6 -1.7 -1.6 -0.9 -0.5 -2.0 -0.3 -0.1 -1.6 0.2
Medication for hormone replacement therapy 1.0 1.1 5.6 -0.0 0.1 -0.6 -2.0 -1.4 2.4 0.4 -1.6 -1.0 -0.7 -0.5 1.6 -0.4 -0.5 0.3 1.4 1.4 0.7 -0.0 1.3 -0.5 0.3 0.9 -0.1
Vitamin and mineral supplements 1.2 1.6 10.4 -0.9 0.9 0.1 2.4 1.0 -0.8 -1.7 2.3 -0.4 0.6 3.2 -0.1 0.7 -0.7 1.4 -0.1 -0.2 0.6 0.7 -0.9 -1.4 1.9 0.5 0.0
Supplements: Zinc 1.7 1.9 15.1 0.7 -1.2 0.3 -2.5 -1.7 0.4 1.6 -1.6 -1.1 -1.6 -3.9 0.8 -1.2 0.8 -0.8 0.1 1.0 -0.8 -0.3 1.8 1.4 -0.1 0.0 -0.3
Medication: Co-codamol 1.4 1.7 9.9 -1.9 -0.5 -2.0 -3.1 -0.8 0.5 0.2 -1.7 -0.5 -0.6 -2.5 0.9 -2.2 -1.1 -0.5 -0.6 0.4 -0.9 0.0 -1.5 0.1 -0.2 -0.8 0.4
Medication: Metformin 1.7 2.4 7.5 0.0 -2.1 0.4 -1.5 -2.2 0.5 1.6 -1.3 -0.4 -1.7 -0.9 -0.5 -0.6 -0.0 -2.7 -1.3 -0.1 -1.5 -1.7 0.5 1.8 -2.6 -2.7 -2.1
Diabetes (father) 1.0 1.2 5.5 -0.8 -0.7 -0.4 -1.0 -0.2 1.4 0.3 -0.3 -2.4 -0.9 0.7 1.7 -1.9 -1.6 1.5 -0.4 0.8 -0.6 -0.0 -1.2 -1.2 1.2 0.9 0.6
Diabetes (mother) 2.1 2.7 6.8 -0.2 -2.4 0.1 -0.5 -2.2 -1.0 2.4 -1.6 -2.1 -2.5 -2.3 0.5 -2.3 -0.2 -1.1 -2.1 -0.2 -2.1 -1.0 0.2 1.4 -1.4 -2.6 -1.1
Severe depression (siblings) 0.8 0.9 3.3 -1.4 -0.2 -1.5 -1.5 -0.3 1.4 -0.6 -1.8 -0.4 -0.2 -0.4 0.7 -0.0 -1.8 0.4 0.3 0.6 0.1 0.4 -1.0 -1.6 0.7 0.1 0.2
Pack years adult smoking proportion 0.8 1.1 6.7 0.3 -0.9 0.0 -1.3 -1.3 0.0 0.9 -2.6 -1.1 -0.8 -1.9 0.6 -1.3 -0.1 -0.7 0.2 0.9 -1.4 0.1 0.9 1.2 -1.3 -1.1 0.2
Impedance of leg (right) 0.4 1.9 6.1 2.5 2.2 2.0 -0.6 1.4 -0.3 -1.1 -0.0 0.8 1.8 0.4 -2.0 -0.4 2.4 -1.1 0.8 -1.3 0.3 -0.1 2.0 0.2 -1.6 1.8 -0.7
Leg fat-free mass (left) 1.4 7.6 19.9 -0.1 -3.8 0.9 0.1 -3.9 -2.1 4.0 -2.7 -3.3 -4.1 -4.4 0.7 -1.1 -0.3 -1.7 -3.3 0.0 -4.5 -3.2 0.3 2.8 -1.6 -3.8 -2.5
Trunk fat percentage 2.1 8.4 22.0 0.0 -3.2 1.3 -0.8 -3.3 -1.4 2.9 -1.6 -2.1 -3.2 -2.2 -3.0 -1.9 0.1 -4.6 -4.4 -3.0 -4.2 -4.0 -0.6 0.5 -4.0 -4.7 -3.7
Hand grip strength (right) 0.5 1.4 4.0 0.5 -1.3 0.2 0.7 -1.5 -1.5 1.9 -0.5 -1.1 -1.5 -1.0 0.9 1.1 0.2 -0.1 -0.5 0.5 -1.3 -1.6 1.6 2.0 -0.2 -1.2 -1.9
Townsend deprivation index at recruitment 0.6 0.9 4.8 -0.6 0.5 -0.3 -2.2 -1.1 -0.2 -0.1 -0.9 -0.3 -0.6 0.2 -1.2 -1.2 -0.5 -1.9 -0.3 -0.3 -0.4 -0.4 0.4 -0.8 -1.7 -0.3 -1.5
Current tobacco smoking 0.5 0.8 2.7 0.8 -0.3 1.0 -0.8 -0.2 1.0 0.6 -0.1 -0.1 0.1 -0.6 -1.3 -0.6 0.1 -1.2 -0.4 -0.4 -1.4 -0.4 1.7 0.1 -1.1 -1.4 -1.3
Average weekly fortified wine intake 0.5 0.6 2.8 1.0 0.9 0.2 1.3 0.7 0.7 0.4 0.2 -0.3 0.8 -0.6 -0.1 0.4 0.4 0.9 1.1 0.4 0.4 0.9 1.7 0.4 0.8 0.4 -0.2
Maternal smoking around birth 1.5 2.2 7.8 0.8 -0.5 1.0 -1.6 -2.3 -0.6 1.3 -0.9 -2.6 -1.9 -1.3 -0.5 -2.8 0.5 -1.4 -1.4 -0.9 -1.7 -1.3 0.9 0.5 -2.3 -1.1 -1.2
Fed-up feelings 0.5 0.9 4.8 0.7 -0.4 -0.1 -1.1 -1.2 0.9 -0.2 -1.3 0.0 -0.6 -2.0 1.5 -0.4 0.3 0.4 0.8 2.2 -0.6 0.4 1.4 -0.5 0.3 -0.4 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 8.8 1.3 0.1 1.0 -1.3 -1.3 0.6 0.8 -1.3 -0.3 -0.5 -3.0 -0.8 -1.2 1.0 -1.6 -0.2 0.5 -1.5 -1.1 2.0 0.6 -1.8 -1.3 -1.9
Relative age voice broke 0.6 1.0 3.1 1.3 -0.3 1.4 -1.8 0.1 -0.8 1.2 -0.0 -0.2 -0.1 -0.9 -1.0 -1.2 1.3 -0.6 -0.9 -1.1 -1.7 -1.0 1.2 0.5 -0.4 -1.1 -0.7
Taking other prescription medications 1.8 2.7 7.7 0.1 -2.8 0.5 -1.1 -2.6 -1.1 2.0 -1.4 -0.6 -2.3 -2.6 -0.5 -1.8 0.1 -2.3 -1.6 -0.8 -2.1 -1.6 -0.4 0.8 -1.6 -2.6 -1.4
Age when periods started (menarche) 0.9 2.2 7.0 1.2 1.3 0.4 1.2 0.8 -2.1 0.0 1.8 0.1 0.8 1.9 1.8 1.4 1.1 2.0 1.6 1.9 0.9 0.8 0.2 2.0 1.8 1.9 2.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.5 -0.8 0.7 -1.3 -1.3 -0.4 1.3 0.2 -0.5 0.2 -0.5 0.9 1.6 0.9 -0.1 0.3 0.4 0.5 1.3 0.9 -0.5 0.4 0.8 -0.0 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 15.2 -0.0 -1.8 -0.9 -0.2 -0.8 0.3 0.8 -0.9 -0.5 -0.5 -0.5 3.7 0.6 -0.9 2.2 2.0 3.9 -0.1 0.9 2.2 2.2 1.9 -0.0 0.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 5.6 -0.5 -0.7 0.5 0.4 0.2 -0.3 -0.5 0.7 -0.1 -0.5 2.4 0.2 -1.1 -0.5 -0.0 -1.1 -0.3 -0.6 -0.1 -0.5 -0.4 -0.4 -0.5 -0.3
Qualifications: CSEs or equivalent 0.1 0.2 0.7 0.3 0.9 0.6 0.8 -0.2 -0.6 0.7 0.0 -0.0 -0.5 -0.2 0.1 -0.1 0.6 0.1 -0.6 -0.6 -0.2 -0.2 0.0 -0.5 0.1 -0.0 0.5
Serious illness, injury or assault to yourself 1.1 1.3 5.0 -0.5 -0.7 0.8 1.4 -0.1 -1.9 0.3 -0.3 -0.0 -0.5 0.4 -1.1 -1.8 -0.3 -0.6 -2.2 -2.2 -1.8 -1.1 -1.8 0.3 -0.4 -1.0 0.5
High blood pressure 0.3 0.9 8.8 -0.3 0.1 -0.9 0.2 -0.2 -0.2 0.2 -1.1 3.0 0.8 -2.3 -0.8 0.5 -0.2 -1.0 -0.4 -0.3 0.5 0.5 -0.8 -0.3 -0.7 -1.2 0.5
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.6 0.7 -0.9 0.7 -0.2 -1.6 0.2 0.8 -0.9 -0.7 -1.0 -0.2 1.0 -0.7 -0.1 0.0 0.3 1.5 -0.9 -0.3 1.6 0.4 0.0 -0.3 -1.4
Multivitamins +/- minerals 1.6 2.0 11.2 1.2 -0.6 0.6 -1.8 -1.1 -0.3 2.1 -2.1 -0.6 -1.1 -3.3 0.3 -0.8 1.3 -1.3 -0.4 0.5 -1.0 -1.1 1.2 2.6 -1.8 -1.1 -0.3
Stomach or abdominal pain in last month 1.2 1.5 6.9 -0.4 -0.0 -1.4 -0.7 -0.4 0.6 -0.1 -0.8 -0.2 -0.3 -0.2 2.2 -0.3 -1.1 2.1 1.4 2.6 0.9 1.2 0.3 1.2 2.0 1.0 1.6
Supplements: Glucosamine 0.6 0.8 3.4 0.5 0.2 0.9 -1.4 0.6 -1.0 -1.0 0.2 0.5 0.6 -0.3 -1.8 -0.7 1.2 -0.7 -0.5 -1.6 -0.4 -0.8 -0.5 -0.7 -1.0 0.5 -1.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.8 1.3 0.3 0.4 -0.2 -0.6 0.7 0.5 -1.3 -0.1 0.0 -1.0 0.1 -0.0 0.6 -0.3 0.5 1.2 -0.2 0.0 1.0 1.4 -0.2 -0.4 0.0
Medication: Atenolol 1.6 2.0 8.4 -0.2 0.0 -0.5 -0.2 -0.9 -0.6 2.4 -2.0 1.6 -1.0 -2.4 -0.8 -0.1 0.2 -1.6 -1.8 -1.4 -1.2 -1.9 -1.5 1.1 -1.2 -2.9 -1.2
Medication: Levothyroxine sodium 0.5 0.8 4.5 -0.4 -2.1 -0.3 -0.5 -1.5 0.4 1.2 -0.5 -1.1 -1.5 0.3 1.2 0.2 -0.9 0.2 0.4 0.9 -0.4 -0.4 0.0 0.7 0.5 -0.5 -1.0
Sitting height 1.6 11.6 33.4 3.9 -2.5 3.6 -0.4 -3.8 -2.0 4.4 -3.7 -2.7 -2.9 -5.8 0.4 -1.8 3.0 -1.9 -2.0 1.4 -4.9 -3.6 4.8 5.2 -2.7 -3.2 -4.0
Chronic bronchitis/emphysema (father) 0.6 0.7 2.9 -0.0 1.3 -0.5 -0.0 0.7 -0.3 -0.4 0.8 1.7 0.8 -0.2 -1.7 0.1 0.3 -1.3 -0.7 -1.6 0.3 -1.0 -0.2 -0.4 -1.3 -0.3 -0.5
High blood pressure (mother) 0.3 0.5 2.0 0.2 0.1 0.2 1.0 0.1 -0.4 1.4 -0.6 1.4 0.1 -1.2 -0.0 -0.4 0.1 0.5 -0.4 -0.8 -0.4 -0.3 -0.5 -0.5 0.9 -0.9 0.9
Body mass index (BMI) 0.8 3.4 11.0 -2.6 -2.7 -1.6 -0.9 -2.5 -0.5 1.8 -0.9 -1.7 -2.6 -1.3 -0.3 -0.8 -2.4 -1.8 -2.6 -0.8 -1.9 -1.8 -2.2 -0.3 -1.0 -3.3 -1.1
Impedance of leg (left) 0.4 1.8 5.4 2.3 1.7 1.8 0.1 1.7 -0.4 -0.9 0.7 1.3 1.9 1.1 -2.0 -0.2 2.3 -1.0 0.8 -1.4 0.4 -0.1 1.6 0.3 -1.4 1.6 -0.6
Leg predicted mass (left) 1.5 7.7 20.2 -0.1 -3.8 0.9 0.0 -3.9 -2.1 4.0 -2.7 -3.4 -4.1 -4.4 0.8 -1.1 -0.3 -1.7 -3.4 0.1 -4.5 -3.2 0.3 2.8 -1.6 -3.8 -2.5
Trunk fat mass 2.2 9.3 22.8 -0.1 -3.6 1.3 -0.7 -3.7 -1.9 3.4 -2.1 -2.8 -3.7 -3.1 -2.3 -1.9 -0.0 -4.2 -4.6 -2.5 -4.6 -4.2 -0.6 1.1 -3.5 -4.8 -3.6
Waist circumference 1.1 4.1 12.7 -1.2 -2.5 -0.0 -0.4 -1.9 -1.4 1.9 -1.0 -1.9 -2.2 -2.1 -1.6 -1.2 -1.0 -2.6 -3.6 -2.1 -2.7 -2.7 -2.0 -0.0 -2.2 -3.5 -1.7
Number of incorrect matches in round 0.6 0.9 2.4 0.9 1.2 1.1 0.1 0.2 -0.8 0.5 0.7 -0.6 -0.2 0.5 -1.5 -1.5 1.0 -1.4 -1.5 -1.2 -0.7 -0.9 1.0 0.9 -0.8 -1.4 -0.6
Past tobacco smoking 1.5 2.8 11.6 -0.6 0.4 -1.1 -0.7 1.6 0.9 -1.4 0.0 0.5 1.2 0.5 2.3 -1.0 -0.8 3.1 1.8 2.2 2.1 2.8 -0.5 -0.3 2.8 1.7 3.4
Alcohol usually taken with meals 0.7 1.2 3.7 0.6 0.8 0.5 1.9 1.0 -0.4 -0.8 1.6 0.4 0.9 0.5 1.1 1.2 1.1 1.9 1.1 1.4 1.4 1.2 -0.1 0.3 1.5 1.2 0.7
Nervous feelings 0.2 0.3 1.6 -0.3 0.1 -0.0 -0.5 0.2 0.4 -0.3 1.1 -0.4 0.1 -0.4 -1.3 -0.3 -0.5 -0.7 -0.5 -1.1 -0.4 -0.7 0.1 -1.0 -0.1 -0.3 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 4.1 0.9 1.3 0.8 -0.5 0.5 2.0 -1.6 -0.6 0.4 1.1 -0.7 -0.4 -0.3 0.9 -0.1 1.1 1.2 1.1 0.9 0.4 -1.3 0.6 0.4 1.1
Hearing difficulty/problems with background noise 1.3 2.1 6.9 0.3 -2.2 1.1 1.6 -0.7 -1.4 0.4 0.7 -0.3 -0.8 0.6 -1.9 -0.8 0.4 -2.6 -2.0 -0.9 -2.3 -2.1 0.1 0.2 -1.9 -1.9 -1.8
Hair/balding pattern: Pattern 2 0.9 1.2 3.9 1.8 1.1 0.9 0.2 1.1 0.9 -0.4 -1.1 1.3 1.6 -1.1 -0.8 0.1 1.7 0.3 1.5 0.4 0.7 1.7 2.0 0.5 0.0 1.1 -0.0
Had menopause 0.6 0.8 3.4 1.2 0.7 1.4 1.0 -0.1 -1.1 -0.8 0.8 0.2 0.2 0.3 -1.3 -0.9 1.8 -1.3 -0.6 -0.7 0.5 0.2 0.3 -1.0 -1.4 0.1 0.0
Had other major operations 0.9 1.0 4.7 0.5 0.8 0.5 0.8 0.4 1.3 -1.5 -1.3 0.2 0.3 -0.6 0.8 0.8 0.6 1.1 1.4 0.6 1.1 0.8 0.1 -1.7 1.1 2.2 1.0
Forced vital capacity (FVC) 0.5 1.8 8.8 -0.2 -0.9 0.1 1.5 -0.5 -2.7 1.3 -0.4 -2.7 -1.1 -1.4 1.8 -0.8 -0.2 1.1 -1.1 0.1 -1.5 -1.3 0.3 3.0 0.0 -0.5 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 12.7 -0.3 -1.0 -1.0 -0.3 -0.7 -0.2 0.6 -0.4 -0.3 -0.5 -0.0 3.5 0.7 -0.7 2.3 2.0 3.6 0.4 0.8 1.3 1.6 2.4 0.6 0.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 3.8 0.7 -1.3 0.9 0.1 -1.2 0.7 0.9 1.0 -0.2 -1.0 0.1 0.0 -0.5 0.1 -0.4 -1.2 -0.6 -1.2 -0.1 0.8 0.8 -0.2 -1.9 -1.2
Qualifications: None of the above 0.6 1.2 3.4 -1.0 1.4 -1.8 -1.0 0.6 0.3 -0.7 -1.6 0.3 0.2 0.3 1.1 0.3 -1.0 0.8 1.8 0.8 1.6 1.2 -1.2 0.2 1.0 1.6 1.3
Financial difficulties in last 2 years 0.3 0.4 1.6 0.2 -0.1 -0.0 0.2 -0.4 0.1 -0.2 -0.9 1.0 0.4 -1.3 -0.6 -0.3 -0.4 -0.8 0.8 0.7 0.2 0.4 1.0 -0.9 -0.4 0.4 0.4
Mouth/teeth dental problems 0.9 1.4 5.8 -1.1 0.2 -0.7 0.7 1.9 -0.8 -1.1 2.4 2.1 1.3 2.0 -0.8 0.9 -0.6 0.7 -0.0 -1.8 1.1 1.5 -0.9 0.2 0.2 0.4 0.3
Heart attack 2.0 2.6 8.6 0.2 -2.5 0.8 0.1 -1.9 -1.6 2.9 -1.5 -1.2 -2.0 -0.6 -0.0 -0.8 -0.1 -1.6 -2.1 -0.8 -2.5 -1.8 0.2 2.0 -1.8 -2.7 -0.6
Allergy 0.9 2.0 5.7 -1.4 2.0 -1.6 1.9 2.4 -0.3 -1.6 1.0 1.5 2.0 0.1 -0.8 2.1 -0.7 0.8 0.6 -1.4 1.6 0.8 -1.4 -0.4 0.5 1.4 2.0
Pain all over the body in last month 1.4 1.5 5.6 1.0 1.4 1.0 1.6 -0.1 -0.4 0.7 0.0 0.4 0.6 0.6 -2.4 -0.9 1.1 -1.9 -1.4 -2.1 -1.2 -1.6 -0.2 0.3 -2.0 -1.5 -1.1
Diabetes (self-reported) 0.8 1.2 2.9 0.5 -1.6 0.9 -1.0 -1.6 -0.1 1.6 0.0 -0.8 -1.4 -0.3 -0.2 -0.7 0.2 -1.2 -1.4 -0.5 -1.0 -1.2 0.1 1.3 -1.5 -1.7 -1.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 3.8 -1.1 -0.6 -1.3 -0.7 -0.3 0.3 0.2 0.3 -0.2 -0.4 0.2 1.6 0.5 -1.4 1.0 0.6 0.7 0.7 0.3 -0.8 -0.4 1.9 0.5 0.8
Medication: Ramipril 1.8 2.3 5.2 -1.5 -1.9 -0.5 0.6 -1.8 -1.6 1.6 -1.8 -0.9 -1.9 -1.0 -0.6 -0.5 -1.6 -2.3 -2.2 -1.0 -1.8 -1.9 -0.8 0.2 -1.7 -2.2 -1.5
Medication: Simvastatin 1.1 1.7 4.8 -1.8 -1.4 -1.6 -0.5 -1.8 0.0 1.4 -1.8 -0.1 -1.6 -0.3 0.4 -1.2 -1.8 -1.5 -1.7 -0.4 -1.0 -1.5 -1.5 0.5 -0.6 -2.2 -0.7
Fluid intelligence score 1.0 2.1 6.8 2.4 -0.8 2.6 -1.3 -1.0 -0.7 0.7 -0.9 -1.4 -0.9 -1.0 -1.0 -1.9 2.6 -1.8 -0.7 0.0 -1.7 -0.9 2.0 0.3 -2.0 -0.7 -1.0
Illnesses of siblings 0.5 0.8 5.0 0.5 -1.0 1.2 0.4 0.6 -0.4 0.0 2.2 -0.3 0.1 1.0 -0.7 -0.6 1.3 -0.3 -0.8 -1.1 -0.6 0.1 -0.9 -1.1 0.5 0.2 1.2
Neuroticism score 0.4 0.9 2.6 1.2 0.5 0.9 -1.3 -1.6 1.1 -0.1 -1.3 -0.8 -0.8 -1.2 -0.1 -0.7 1.0 -1.0 0.3 1.1 -0.4 0.0 1.5 -0.8 -0.7 -0.6 -0.2
Weight 1.6 7.8 18.8 -0.8 -3.9 0.3 -0.8 -3.9 -1.9 3.5 -2.4 -3.2 -4.0 -4.0 -0.3 -1.6 -0.8 -2.7 -3.8 -0.8 -4.3 -3.6 -0.7 1.7 -2.2 -4.3 -2.8
Impedance of arm (right) 0.7 3.5 12.9 3.5 0.3 3.6 -0.8 -0.2 0.6 0.6 -0.7 0.2 0.1 -0.3 -2.5 -1.4 3.3 -2.6 -0.7 -1.7 -1.5 -1.3 2.8 0.5 -3.1 -0.1 -2.4
Arm fat percentage (right) 1.2 4.9 15.6 -1.3 -3.0 -0.1 -1.4 -2.8 -0.5 2.3 -1.1 -1.8 -2.9 -1.6 -1.8 -1.2 -1.0 -3.4 -3.5 -2.1 -2.7 -2.4 -1.5 -0.2 -2.6 -4.0 -2.2
Trunk fat-free mass 1.0 5.8 19.7 0.7 -3.1 1.2 0.9 -3.1 -2.9 3.6 -2.4 -2.9 -3.3 -4.4 1.4 -0.3 0.5 -0.7 -2.5 0.7 -3.6 -2.7 0.8 3.5 -0.8 -2.6 -1.7
Hip circumference 1.5 6.4 18.1 -1.2 -3.8 0.0 -0.6 -3.1 -1.5 2.9 -1.3 -2.1 -3.2 -3.1 -1.2 -1.4 -1.1 -2.9 -3.9 -1.6 -3.9 -3.4 -1.3 0.7 -2.2 -4.2 -3.0
Time employed in main current job 2.2 2.5 6.2 -0.8 0.9 -1.7 0.0 1.3 1.4 -1.0 -1.0 0.9 1.4 1.4 2.3 1.5 -1.4 2.5 2.4 1.9 2.3 1.9 -0.2 0.8 1.6 2.2 1.9
Alcohol intake versus 10 years previously 0.6 0.8 6.2 0.4 -0.9 0.4 -2.5 -1.5 -0.3 0.0 -0.8 -1.5 -0.7 -0.1 0.2 -1.1 0.3 -1.1 -0.1 0.7 -0.8 -0.6 0.8 0.5 -1.2 -0.7 -0.3
Father’s age at death 1.1 1.5 3.5 -0.5 1.1 -1.1 -1.6 1.0 1.5 -0.7 -1.7 0.6 1.0 -1.3 0.8 -0.0 -0.7 1.2 1.5 0.7 1.7 1.1 -1.4 -1.0 1.2 1.7 1.9
Worrier / anxious feelings 0.5 1.0 6.6 2.2 0.4 1.8 -0.4 -0.6 -0.0 -0.4 0.3 0.8 0.2 0.2 -1.1 0.7 2.6 -1.3 0.3 0.4 0.4 -0.5 1.4 -0.6 -0.8 0.5 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 4.6 2.1 -0.4 1.7 -1.9 -0.9 1.3 0.0 -0.9 0.5 -0.0 -1.5 -1.7 -1.3 1.8 -1.9 -0.4 -0.4 -0.3 -0.4 1.5 -0.7 -2.0 -1.8 -1.8
Falls in the last year 0.6 0.8 2.6 -0.5 -0.5 0.0 1.3 1.0 0.1 -0.7 0.8 1.0 0.9 -0.4 -1.1 -0.2 0.2 -0.5 -1.6 -1.4 -0.3 -0.1 -1.4 -1.0 -0.7 -1.5 0.6
Hair/balding pattern: Pattern 3 0.6 0.8 5.3 1.2 0.3 0.6 0.7 0.6 0.1 -0.4 0.7 1.4 0.7 0.7 -0.5 2.3 1.0 -0.6 1.3 0.4 1.1 -0.4 0.4 -0.5 -0.8 1.5 -0.1
Number of live births 1.5 2.2 6.3 -2.2 0.6 -1.3 -0.0 1.4 0.3 -2.0 -0.5 -0.7 0.2 2.0 1.6 -0.4 -1.9 1.7 0.7 0.6 1.3 1.4 -2.5 -2.0 2.0 1.4 2.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 10.0 -1.4 -1.5 -1.2 1.9 -0.4 -2.1 1.2 -0.3 -2.3 -1.2 -0.9 3.2 0.6 -1.6 2.2 -0.1 1.0 -0.4 -0.4 -0.3 2.5 1.5 0.5 0.8
Pulse rate 0.9 1.6 4.9 0.4 1.4 -0.3 -0.4 1.6 -0.1 -1.6 1.9 0.3 1.9 0.9 -0.4 -0.8 0.4 2.1 1.5 0.2 1.3 2.2 0.3 -0.3 1.4 1.3 1.9
Happiness 0.4 0.5 2.6 0.2 -0.7 0.1 1.6 0.2 -0.7 -0.8 1.5 1.3 0.5 -0.1 0.5 0.6 0.1 0.8 0.5 0.8 0.2 0.8 0.5 -0.5 0.4 0.4 0.1
Noisy workplace 0.5 0.6 2.6 -1.1 -1.3 -0.5 -1.6 -0.4 -0.0 0.2 0.3 -0.9 -0.8 1.2 0.1 -1.4 -0.4 -0.5 -0.8 -0.4 -1.0 -0.4 -1.0 -0.2 0.2 -0.8 -0.6
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.6 -0.1 0.6 -0.1 0.4 1.0 0.6 -0.2 0.6 0.7 0.7 0.7 0.8 -0.1 0.1 1.3 0.6 0.6 0.7 0.8 -0.1 -1.1 1.2 0.8 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.9 -0.4 -0.4 -0.0 -1.0 0.2 -0.4 0.2 0.7 -0.3 -0.6 0.9 0.3 -0.2 -0.2 0.2 -0.2 -0.8 0.2 -0.4 -1.0 -0.1 0.1 -0.2 -0.6
Mouth/teeth dental problems: Dentures 1.7 2.9 8.0 0.2 -2.1 0.3 -0.7 -2.8 -1.0 2.3 -2.0 -2.4 -2.6 -2.7 1.1 -1.2 0.0 -1.4 -1.3 1.4 -2.3 -2.1 0.5 1.4 -0.8 -2.0 -1.7
Asthma 1.0 1.9 7.0 1.2 -2.1 1.9 -2.6 -1.6 -0.1 1.4 0.6 -0.5 -1.6 -0.2 -0.7 -2.5 1.3 -1.6 -1.3 -0.5 -1.3 -0.9 -0.2 -0.5 -1.0 -1.4 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.8 1.6 1.0 0.6 -0.4 1.1 1.2 -0.9 1.0 1.5 2.0 0.3 -0.9 -0.1 1.3 -0.5 1.0 0.1 0.5 0.7 1.7 -0.0 -0.9 0.3 -0.2
Medication: Cholesterol lowering 1.0 1.6 6.4 -1.7 -0.9 -1.5 -0.1 -1.5 -0.8 1.6 -2.5 0.1 -1.4 -0.7 0.5 -0.6 -1.7 -1.1 -1.4 -0.2 -1.1 -0.9 -1.4 1.1 -0.9 -2.0 -0.9
Depression (self-reported) 0.5 0.6 6.6 -0.5 -1.3 -0.9 -0.9 -0.4 2.6 -0.6 -0.0 -0.9 -0.2 0.1 -0.2 -0.7 -1.0 -0.5 0.0 0.2 -0.1 0.4 0.1 -0.6 -0.3 -0.3 -0.2
Medication: Lansoprazole 1.1 1.3 5.9 -0.9 -0.3 -1.0 -0.2 0.9 -0.2 -1.1 -0.6 0.6 0.8 0.8 1.5 -0.7 -1.4 1.8 1.1 0.5 0.8 1.6 -0.9 -0.1 1.6 1.6 2.4
Prospective memory result 0.6 0.7 2.9 -1.6 -0.3 -1.6 0.8 0.2 0.3 0.5 1.4 0.6 -0.2 0.4 -0.6 0.4 -1.3 -0.2 -0.9 -0.9 0.2 -0.1 -1.7 0.5 0.6 -0.9 0.7
Lung cancer (father) 1.0 1.2 10.0 -1.3 -0.1 -1.5 -3.2 0.3 1.8 -0.8 -0.8 -0.1 0.5 -1.0 0.5 -1.6 -1.2 0.3 0.9 0.6 0.8 0.8 -0.1 -1.0 0.7 -0.1 0.8
Illnesses of mother 0.7 0.9 5.1 0.4 0.1 -0.1 -0.7 0.2 1.0 -1.3 0.8 -0.1 0.6 1.5 0.9 0.6 0.3 0.1 1.5 2.3 1.0 1.0 0.9 1.0 0.2 1.0 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 11.6 -2.1 -1.5 -1.8 1.2 -0.6 -1.5 1.6 -0.9 -2.3 -1.6 -0.6 3.4 0.3 -2.4 1.9 -0.7 1.3 -0.7 -0.5 -0.8 2.5 1.8 -0.5 0.8
Pulse wave Arterial Stiffness index 0.6 0.7 2.3 0.7 1.5 0.3 -1.1 1.2 1.4 -0.8 -0.7 0.4 1.5 -0.1 -0.5 0.4 0.3 0.1 1.1 0.0 0.6 0.9 0.9 -0.1 -0.3 1.0 0.1
Impedance of arm (left) 1.1 5.0 14.8 3.6 -0.1 3.9 -1.5 -0.8 0.2 0.7 -0.9 -0.9 -0.4 -0.8 -3.2 -2.3 3.5 -3.3 -1.6 -2.4 -2.3 -2.1 2.7 0.3 -3.8 -1.0 -2.9
Arm fat mass (right) 1.8 7.5 20.2 -1.0 -4.0 0.3 -0.9 -3.8 -1.6 3.4 -1.7 -3.0 -3.9 -2.5 -1.2 -1.6 -1.0 -3.3 -4.1 -1.7 -3.9 -3.5 -1.1 1.0 -2.6 -4.5 -2.7
Trunk predicted mass 1.0 6.0 19.5 0.6 -3.2 1.1 0.8 -3.2 -2.9 3.6 -2.4 -2.9 -3.3 -4.4 1.4 -0.4 0.4 -0.7 -2.5 0.6 -3.6 -2.7 0.7 3.5 -0.7 -2.7 -1.7
Standing height 1.3 13.3 36.4 3.9 -3.2 4.4 1.0 -3.5 -3.7 4.4 -3.1 -3.6 -3.6 -6.0 -0.1 -1.7 3.3 -2.4 -3.2 -0.2 -5.9 -4.5 3.6 4.9 -2.9 -2.7 -4.3
Length of working week for main job 0.6 0.6 2.6 1.1 -0.4 0.6 0.2 -0.8 0.5 0.8 -0.9 0.5 -0.3 -1.4 -0.3 0.2 0.6 -0.5 0.2 0.0 -0.7 -0.3 1.6 1.4 -0.6 -0.9 -1.3
Exposure to tobacco smoke at home 0.6 0.7 5.2 -1.0 0.9 -0.5 -0.9 0.3 -0.2 0.1 -2.3 -0.6 0.1 0.2 -0.7 -0.8 -1.3 -0.2 -0.5 -1.1 -0.9 -1.1 -0.2 0.2 -0.4 0.9 -0.9
Breastfed as a baby 0.6 0.8 6.1 -0.6 -0.9 -0.1 0.4 0.3 -0.1 -0.6 2.5 0.1 -0.1 0.9 -1.3 1.0 -0.2 -0.6 -0.5 -1.1 0.7 0.2 -1.0 -1.6 0.5 0.7 0.2
Tense / ‘highly strung’ 0.4 0.6 1.5 0.8 1.1 0.2 1.2 0.4 0.2 -0.7 1.2 -0.1 0.8 -0.8 -0.1 0.1 0.8 0.4 0.7 1.0 0.4 0.9 1.0 -1.1 0.7 1.0 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 5.2 0.6 -1.0 0.3 -2.3 -1.2 1.1 0.9 -0.3 -1.0 -0.5 -1.3 -0.3 -1.3 -0.2 -1.4 -0.0 0.5 -1.0 -0.4 2.0 0.7 -0.8 -0.8 -1.4
Hair/balding pattern: Pattern 4 0.6 1.6 5.0 -1.5 1.3 -1.8 -2.0 0.7 2.0 -2.2 0.4 1.5 0.9 -0.0 -0.0 0.5 -0.8 0.3 0.8 -0.6 1.7 0.7 -1.3 -2.2 0.5 0.9 0.8
Birth weight of first child 1.1 2.0 6.9 -1.7 0.3 -1.7 1.0 2.0 -0.1 -1.6 2.6 0.4 1.3 1.5 -0.7 -0.4 -0.9 0.6 0.5 -1.2 1.6 0.8 -2.4 -2.5 1.1 1.5 1.2
Peak expiratory flow (PEF) 0.8 1.9 8.1 -0.7 -1.5 -0.7 2.8 -1.4 -1.9 1.4 0.1 -1.3 -1.6 -0.5 2.8 1.6 -1.1 1.4 0.1 1.3 0.1 -0.6 -0.0 1.9 1.3 0.8 0.4
Pulse wave reflection index 0.3 0.4 1.6 -1.0 0.2 -0.1 0.9 0.1 -1.0 0.2 0.9 0.0 -0.6 0.3 0.2 0.6 -1.3 -0.1 -0.6 -0.8 -0.3 -0.3 -0.9 -0.4 0.2 0.4 0.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 4.5 -0.5 -0.6 -0.1 -0.7 -0.8 0.1 1.2 -0.2 -1.0 -1.1 1.7 2.1 -0.7 -0.9 1.3 -0.4 1.0 -1.1 -0.5 0.5 0.9 0.5 -0.4 -0.6
Loud music exposure frequency 1.2 1.3 4.8 -0.7 0.4 -1.3 1.3 0.5 1.3 -1.4 0.5 0.1 1.0 0.9 1.6 0.7 -1.0 1.4 1.6 2.2 0.7 1.3 0.8 -0.1 1.8 0.7 1.2
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 6.0 0.3 1.3 -0.3 1.7 2.2 1.3 -0.4 1.1 2.5 1.8 0.1 -0.0 2.2 0.2 1.4 1.1 -0.0 1.8 1.0 -0.2 -0.9 0.4 1.0 0.9
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.1 -0.2 1.8 -0.3 0.4 0.5 0.5 -1.2 -1.0 -0.8 1.0 1.0 -0.6 -1.1 0.1 -0.0 0.4 -0.0 0.0 -0.5 -1.0 -0.9 -0.7 1.0 1.0
Blood clot in the leg (DVT) 0.9 1.2 14.0 -0.0 0.0 -0.5 -3.7 -0.2 1.7 0.1 -1.9 -0.9 -0.0 -0.9 0.2 -1.7 -0.3 -0.1 -0.2 -0.1 -0.7 -0.2 -0.0 0.3 -0.9 -0.8 -0.3
Medication: Paracetamol 0.4 0.7 3.5 0.5 0.9 -0.1 -1.9 0.2 1.0 -0.3 0.5 0.9 0.8 -0.0 0.5 -0.6 0.9 0.5 1.0 0.9 0.7 1.9 0.6 0.3 0.0 -0.2 0.9
Headache pain in last month 1.1 1.9 9.0 1.0 2.4 -0.0 -3.0 1.1 1.5 -1.4 -1.7 0.7 1.6 -0.9 0.3 -0.8 1.5 0.9 1.9 1.3 1.6 1.4 1.3 -0.4 0.3 1.0 1.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 4.5 1.4 0.6 1.3 0.9 1.1 0.8 -1.8 2.1 -1.0 1.0 1.6 -0.2 0.1 1.1 1.3 1.2 0.5 0.9 0.9 1.3 -1.2 1.0 1.6 0.5
Glaucoma (self-reported) 0.3 0.3 2.5 0.0 -0.4 0.1 0.6 -1.0 -1.3 0.7 0.2 -0.2 -0.8 -1.6 -0.6 -0.2 0.2 -0.1 -0.3 -0.7 0.1 0.3 -0.2 -0.2 0.2 -0.0 0.1
Gout (self-reported) 0.3 0.5 1.9 0.9 0.7 1.3 0.0 1.0 -0.4 0.3 -0.6 0.6 0.5 -0.6 -1.0 -0.0 1.4 0.1 -0.5 -1.3 -0.1 -0.5 -0.2 0.6 0.1 0.5 -0.1
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 7.5 -1.1 -2.7 -0.6 -0.8 -1.4 -0.1 0.7 0.4 -0.7 -1.4 0.2 0.2 -0.8 -0.9 -0.7 -0.6 -0.4 -0.7 -1.1 -0.7 -0.3 0.0 -1.4 -1.0
Medication: Amlodipine 1.2 1.6 8.2 0.6 -1.4 0.7 -0.2 -2.0 -2.9 1.9 -0.6 -0.5 -1.5 -1.1 0.6 -1.0 0.9 -1.7 -1.2 0.9 -1.0 -1.2 0.2 2.2 -0.8 -1.3 -0.1
Medication: Ventolin 100micrograms inhaler 1.3 1.6 4.7 1.8 -0.0 2.2 -0.5 -1.0 -0.8 1.1 -0.9 -0.3 -0.9 -1.2 -1.7 -0.6 2.0 -1.9 -1.1 -1.2 -1.3 -0.9 1.1 0.2 -1.9 -0.7 -1.9
Birth weight 0.2 0.3 1.2 0.5 0.6 -0.3 0.3 -0.0 0.3 0.3 0.7 -0.7 0.3 -0.4 0.4 0.8 1.1 -0.1 0.9 0.9 0.2 0.5 1.1 0.7 -0.3 0.1 0.1
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.7 -0.4 -0.1 -0.2 -1.2 -0.8 1.3 0.5 -1.4 -1.6 -0.7 -0.2 -0.9 -1.5 -0.6 -0.7 -0.9 -1.1 -1.0 -1.0 -0.4 -0.8 -1.2 -1.6 -0.4
High blood pressure (siblings) 0.7 1.0 3.7 -0.0 -0.1 -0.3 0.4 -0.9 -0.8 0.9 -1.9 0.5 -0.4 -1.6 -0.9 0.4 -0.6 -1.2 -0.6 -0.9 -0.7 -1.3 0.6 1.2 -1.8 -1.4 -1.4
Forced vital capacity (FVC), Best measure 0.5 1.7 7.6 -1.2 -1.0 -0.8 0.2 -0.6 -1.6 1.5 -1.1 -2.8 -1.4 -1.3 1.9 -0.8 -1.1 0.8 -1.3 0.4 -1.5 -1.1 -0.3 2.4 0.4 -1.4 -0.2
Body fat percentage 1.5 5.8 17.3 -0.9 -2.8 0.2 -1.4 -2.7 -0.8 2.1 -1.3 -1.7 -2.7 -1.9 -2.5 -1.5 -0.6 -4.0 -3.7 -2.5 -3.1 -3.0 -1.5 -0.1 -3.1 -4.2 -2.7
Leg fat percentage (right) 0.9 3.3 8.6 -2.1 -1.6 -1.2 -2.2 -1.8 -0.2 1.0 -1.4 -1.1 -1.6 -1.6 -1.9 -1.2 -1.7 -2.9 -2.6 -2.0 -1.6 -1.7 -2.2 -0.8 -2.0 -2.9 -1.6
Arm fat-free mass (right) 1.0 5.4 12.9 -0.4 -3.2 0.3 0.9 -3.1 -2.9 3.5 -2.0 -3.2 -3.4 -3.6 1.5 -0.6 -0.6 -0.6 -2.6 0.6 -3.5 -2.7 -0.2 3.0 -0.4 -2.7 -1.6
Exposure to tobacco smoke outside home 0.5 0.7 6.4 -1.3 0.3 -0.6 -0.5 0.1 -1.1 -0.5 -1.1 0.4 -0.4 0.8 0.8 -0.4 -0.5 0.9 -0.2 -0.5 0.3 -0.1 -2.5 -0.5 0.5 1.1 1.0
Comparative body size at age 10 0.1 0.3 1.7 -0.7 0.1 -0.1 -0.7 -0.2 1.3 -0.1 0.6 -0.2 -0.3 -0.4 -0.3 -0.0 0.1 -0.4 -0.6 -0.7 0.1 0.1 -1.3 -0.9 0.1 -0.2 -0.7
Number of full brothers 0.6 0.7 3.6 1.4 0.7 1.0 -0.3 -0.7 -1.4 1.2 1.3 -0.9 -1.0 0.8 -0.0 -0.6 1.9 -0.5 0.1 -0.1 -0.1 -0.5 0.8 0.8 -0.3 0.6 -0.1
Worry too long after embarrassment 1.0 1.7 6.6 2.4 -0.0 2.4 0.3 -1.7 0.3 0.8 -0.4 -1.1 -0.9 -1.4 -0.5 -0.3 2.0 -1.3 -0.3 0.6 -1.5 -0.6 2.6 1.0 -1.5 -1.0 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.3 10.4 -1.9 -1.6 -1.3 -3.2 -2.1 1.5 1.7 -2.1 -2.8 -2.1 -2.0 -0.2 -2.2 -2.5 -1.9 -1.6 -0.6 -2.1 -1.1 0.2 -0.1 -1.3 -2.1 -1.1
Wheeze or whistling in the chest in last year 0.9 1.7 6.8 1.1 0.1 1.7 -2.6 -0.7 1.0 -0.7 -0.9 -0.2 -0.2 -1.2 -2.1 -1.7 1.3 -2.2 -0.9 -1.2 -0.8 -0.3 0.2 -2.2 -1.2 -0.9 -0.7
Number of children fathered 0.9 1.1 4.1 1.8 -0.0 1.9 0.2 0.2 -0.3 0.3 -0.3 0.6 0.5 -0.4 -1.2 -2.0 1.6 -0.6 -1.4 -1.1 -0.8 -1.2 -0.2 0.6 -1.2 -0.8 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.5 -0.1 1.2 -0.2 -0.5 1.3 -0.0 -1.3 0.8 1.6 1.2 0.9 -0.4 1.0 0.4 0.2 1.0 -0.3 1.5 0.6 -1.2 -1.3 0.4 1.4 0.4
Age at first live birth 0.4 0.6 2.4 -0.6 -1.0 -0.8 1.1 -0.3 -0.8 1.3 1.2 -0.2 -0.7 -1.1 0.7 1.0 -0.6 0.4 -0.5 0.4 -0.5 -0.7 0.0 1.5 0.7 -0.3 -0.7
Pulse wave peak to peak time 0.7 0.8 2.9 -0.6 -1.7 -0.1 1.2 -1.3 -1.5 1.0 0.5 -0.6 -1.6 -0.1 0.4 -0.4 -0.2 -0.3 -1.4 -0.1 -0.9 -1.2 -0.8 0.3 0.2 -1.2 -0.3
Health satisfaction 0.3 0.5 1.4 0.2 -0.7 0.5 -0.8 -0.1 -0.4 -0.8 1.2 0.9 0.2 -0.4 -1.0 -1.0 0.6 -0.6 -0.5 -0.7 -0.5 1.0 0.1 -0.9 -0.7 -0.2 -0.0
Shortness of breath walking on level ground 3.0 3.5 10.5 0.5 -1.3 1.4 -3.0 -1.2 1.4 0.7 -2.4 -1.0 -1.1 -2.8 -2.3 -3.2 0.4 -2.5 -1.9 -2.3 -2.7 -1.1 -0.5 -0.6 -2.4 -1.8 -1.5
Qualifications: College or University degree 1.3 4.2 11.2 1.6 -1.5 2.4 0.1 -2.7 -1.1 2.4 -1.3 -2.3 -2.2 -1.3 -0.3 -2.8 2.1 -2.1 -2.4 0.2 -3.3 -2.3 1.4 2.4 -1.7 -2.5 -2.3
Eye problems/disorders: None of the above 0.8 0.9 3.6 0.5 0.7 0.2 0.9 1.2 -0.1 -1.9 -0.7 1.9 1.4 -0.2 -0.7 1.9 0.4 -0.1 1.0 0.5 1.1 0.5 0.1 -0.5 -0.2 1.4 0.7
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 -0.9 -1.0 -0.2 0.1 0.3 0.1 -0.4 -1.3 -0.2 -0.6 -0.4 1.4 -1.2 -1.1 1.4 -0.4 0.2 -0.3 0.9 -0.4 0.0 1.0 -0.2 0.6
Emphysema/chronic bronchitis 3.1 3.5 11.2 0.5 -1.7 1.1 -1.8 -2.6 -0.9 2.3 -1.2 -2.4 -2.7 -1.4 0.0 -2.0 0.7 -1.9 -2.2 -0.4 -3.1 -3.3 0.7 1.6 -1.5 -2.0 -2.0
Medication for pain relief, constipation, heartburn 0.7 1.2 3.2 -1.4 0.5 -1.4 0.8 0.9 1.1 -1.1 0.3 -0.2 0.5 0.5 0.8 1.1 -1.6 1.7 1.0 0.6 1.3 0.5 -1.1 -1.2 1.8 1.6 0.4
Neck or shoulder pain in last month 1.9 2.7 8.2 -0.1 1.1 -0.6 -2.7 0.1 2.2 -0.8 -2.4 -0.1 0.3 -1.5 1.9 0.5 -0.8 2.5 2.9 2.2 1.7 1.6 0.4 -0.6 2.4 1.9 1.9
Medication: Blood pressure 0.8 1.4 7.5 -0.3 -0.9 -0.1 -1.0 -1.3 -0.4 1.7 -1.7 0.5 -0.9 -2.7 -0.6 -0.2 0.0 -1.7 -1.4 -0.4 -1.1 -1.2 -0.8 0.7 -1.3 -2.1 -0.4
Angina (self-reported) 0.8 1.0 4.0 -2.0 -0.7 -1.2 0.4 -0.1 -0.1 0.6 -0.6 -0.3 -0.6 1.3 -0.2 -0.8 -2.0 -0.3 -1.6 -1.3 -0.9 -0.3 -1.9 -0.2 0.2 -1.4 0.4
Migraine (self-reported) 0.5 0.6 4.3 0.1 0.9 -0.1 -0.4 0.7 0.8 -2.1 0.6 -0.7 1.0 1.1 -0.6 -0.2 0.6 0.3 0.7 -0.1 0.8 1.1 0.3 -0.2 0.2 0.7 0.4
Medication: Ibuprofen 1.4 1.7 7.0 1.8 1.3 1.0 0.4 1.8 0.8 -1.5 1.5 2.0 2.6 0.3 -1.6 -0.1 1.6 -0.6 1.0 -0.5 0.6 1.0 2.0 -0.4 -1.4 0.4 -0.3
Medication: Allopurinol 0.7 1.0 3.9 1.3 1.1 1.7 -0.0 0.8 -1.0 0.2 -0.3 0.5 0.6 -0.5 -1.8 -0.2 2.0 -0.8 -0.6 -1.9 -0.0 -0.3 -0.0 0.7 -1.3 0.6 -0.4
Medication: Omeprazole 0.6 0.7 3.2 1.8 -0.1 1.1 0.1 -0.6 -0.5 0.7 0.8 -0.2 -0.2 -1.1 0.2 0.7 1.7 -0.1 0.3 1.2 0.2 0.0 1.2 1.3 0.5 0.2 0.4
Medication: Seretide 50 evohaler 0.3 0.3 3.4 0.4 0.4 0.2 -1.8 -0.2 0.2 0.7 -0.8 0.5 -0.3 -0.3 0.5 -0.4 0.7 -0.8 -0.2 0.7 -0.0 -0.3 -0.2 0.2 -0.3 -0.2 0.4
Mean time to correctly identify matches 0.5 1.0 2.6 -0.4 1.4 -1.0 1.5 1.2 0.7 -1.5 -0.7 1.4 1.2 0.1 -1.6 0.9 -0.3 -0.6 0.7 -0.7 0.6 0.2 0.0 -1.5 -0.5 1.5 0.4
Heart disease (mother) 0.6 0.8 2.7 -0.4 1.6 -0.0 -0.5 0.9 0.7 -1.2 -1.1 1.6 0.9 0.5 -0.8 0.1 0.2 -0.4 -0.1 -1.1 1.3 0.3 -1.3 -1.4 -0.4 0.2 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 10.0 -2.1 -0.7 -2.3 -0.8 -0.8 0.5 0.2 0.7 0.2 -0.9 -0.2 3.2 0.9 -2.0 2.0 0.8 2.2 1.8 1.0 -1.2 0.0 2.8 1.4 1.2
Whole body fat mass 1.7 7.1 18.8 -0.8 -3.4 0.5 -1.0 -3.3 -1.6 2.9 -1.7 -2.6 -3.4 -2.8 -1.8 -1.6 -0.6 -3.6 -4.1 -2.2 -3.8 -3.5 -1.3 0.6 -2.9 -4.3 -2.8
Leg fat mass (right) 1.2 4.5 11.8 -1.6 -2.8 -0.5 -1.5 -2.8 -1.1 2.3 -1.6 -2.3 -2.9 -2.4 -1.1 -1.3 -1.4 -2.8 -3.1 -1.3 -2.8 -2.4 -1.7 0.3 -1.8 -3.4 -1.8
Arm predicted mass (right) 1.0 5.1 14.2 -0.3 -3.2 0.3 0.5 -3.1 -2.7 3.3 -2.0 -3.0 -3.4 -3.8 1.5 -0.6 -0.4 -0.7 -2.5 0.7 -3.4 -2.5 -0.3 2.9 -0.3 -2.9 -1.2
Pulse rate, automated reading 0.6 1.9 7.3 1.9 2.0 2.3 -0.1 1.6 -1.6 -0.8 1.5 1.0 1.3 0.9 -2.0 -1.9 2.7 -0.3 -0.7 -1.9 -0.0 0.8 0.3 -0.1 -0.5 -0.1 0.6
Alcohol intake frequency. 0.6 1.4 8.2 -2.0 0.3 -2.9 -1.6 0.3 0.6 0.2 -0.8 1.5 0.5 -1.0 1.6 0.2 -1.9 0.8 1.0 1.5 0.8 0.6 -0.6 0.8 1.0 0.0 1.4
Comparative height size at age 10 1.6 8.8 26.6 3.1 -2.4 3.4 1.2 -3.2 -2.6 3.9 -2.3 -2.9 -3.1 -5.2 0.1 -1.4 2.3 -1.5 -2.5 0.0 -4.5 -2.9 3.1 4.4 -2.0 -2.6 -3.9
Number of full sisters 0.4 0.4 1.8 -0.2 -0.5 -0.4 -1.3 -0.8 -1.1 0.6 -0.4 -0.1 -1.0 -0.7 0.6 1.1 0.1 0.2 0.2 0.2 0.5 0.3 -0.9 0.6 0.2 0.9 0.6
Suffer from ‘nerves’ 0.4 0.7 1.7 0.7 -0.7 1.0 0.3 -0.9 0.3 0.1 1.1 -1.1 -0.6 -0.7 -1.2 -0.1 0.8 -1.2 -0.7 -1.1 -1.3 -0.3 0.9 -1.1 -0.7 -0.7 0.1
Overall health rating 0.4 0.8 2.1 1.4 1.0 1.2 -0.9 -0.2 -0.1 -0.4 -1.4 1.0 0.3 -0.9 -1.4 -0.8 1.4 -1.3 -0.1 -0.6 -0.5 0.3 0.8 -0.5 -1.3 0.2 -0.2
Chest pain or discomfort 1.5 2.1 7.8 1.7 0.5 2.2 -0.3 -1.4 -0.7 0.5 -2.8 -1.2 -1.0 -1.3 -1.4 -1.9 1.5 -1.5 -1.6 -1.0 -2.5 -1.7 0.1 -0.3 -1.8 -0.5 -1.1
Had major operations 0.9 1.1 5.3 -1.3 0.3 -2.0 -1.0 -0.9 0.5 -0.1 -1.2 -0.8 -0.2 -0.3 1.1 0.1 -2.3 1.2 1.5 1.6 -0.1 0.3 1.4 0.8 0.7 0.4 -0.3
Age at last live birth 0.4 0.6 3.2 -1.0 0.7 -0.8 0.7 0.6 -0.2 0.3 -0.1 -0.3 -0.1 -0.6 1.0 0.3 -0.9 1.7 -0.1 0.1 0.1 0.1 -1.4 0.5 1.8 0.3 0.9
Family relationship satisfaction 0.8 1.0 2.9 -0.9 -1.3 -0.8 -0.2 -1.5 0.3 0.4 -1.5 -0.5 -1.2 -1.7 0.0 -1.2 -1.2 -1.2 -1.0 -0.2 -1.3 -1.1 0.2 -0.3 -1.0 -1.3 -1.0
Leg pain on walking 0.9 1.1 4.4 -0.7 1.2 -0.9 -0.6 1.2 1.7 -1.3 -1.3 0.6 1.5 -0.8 -0.5 0.1 -1.0 0.9 1.3 -0.1 0.6 2.1 -0.3 -1.2 0.4 0.9 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 5.2 -2.3 -0.2 -1.8 -0.8 1.2 -0.4 -1.1 0.3 0.6 0.5 1.7 0.5 0.5 -1.9 0.7 0.3 -0.1 1.0 0.7 -1.5 -0.9 0.7 0.5 0.8
Commuting to job workplace: Car/motor vehicle 1.3 1.5 6.0 -1.0 -0.8 -1.0 -0.2 0.3 0.5 -0.9 -0.1 -0.5 0.4 -0.7 2.2 0.1 -1.0 2.1 1.1 1.3 1.2 1.0 -1.2 -0.9 2.3 1.7 2.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.8 -0.6 -0.2 -1.4 -0.7 1.2 0.4 -0.7 1.2 0.1 1.0 -0.4 1.0 1.7 -0.5 1.7 1.0 0.6 1.0 1.0 0.4 0.5 1.0 0.8 0.5
Medication: Aspirin 4.0 5.3 14.2 -0.3 -1.5 1.1 1.4 -2.6 -3.1 3.5 -2.2 -1.9 -3.1 -1.5 -0.9 -1.0 -0.5 -2.9 -3.8 -2.2 -3.2 -3.2 -0.7 2.0 -2.4 -3.4 -1.2
Supplements: Vitamin C 1.0 1.1 4.2 -0.2 0.1 -1.5 -1.4 0.1 1.0 0.3 -0.8 1.3 0.7 -1.1 1.3 1.4 -0.6 1.0 1.9 1.1 1.5 1.0 0.5 0.4 0.8 2.0 0.4
Knee pain experienced in last month 0.8 1.3 4.1 -1.7 -0.2 -1.4 -1.3 -0.1 1.1 0.1 -1.3 -0.6 -0.5 -1.0 2.0 0.5 -1.7 1.7 0.8 0.9 0.4 1.3 -1.0 -0.7 1.9 0.6 1.4
Hypertension (Self-reported) 0.3 0.9 7.8 -0.6 0.2 -0.9 0.0 -0.0 -0.2 0.1 -0.9 2.8 0.9 -2.1 -0.8 0.4 -0.2 -0.9 -0.5 -0.5 0.6 0.4 -1.4 -0.6 -0.5 -1.1 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.7 -0.9 -0.5 -0.6 -0.3 -0.4 -1.2 -0.4 -0.6 0.1 -0.4 1.0 -0.0 -0.6 -0.7 -0.9 -1.2 -0.5 0.0 -0.8 -1.6 -0.4 -0.3 -0.3 0.1
Illnesses of father: Heart disease 1.5 2.1 6.1 0.4 -1.6 1.3 1.4 -2.4 -1.0 1.2 0.1 -2.0 -2.5 0.3 -0.5 -1.1 0.1 -1.9 -1.9 -0.8 -2.0 -2.1 0.9 0.1 -1.4 -1.5 -2.0
Illnesses of siblings: Diabetes 1.7 2.1 14.1 0.7 0.0 -0.1 -2.3 -1.1 0.8 1.3 -3.7 0.6 -0.4 -2.8 1.0 0.5 -0.1 -0.7 0.7 1.4 -0.5 -1.2 1.8 2.1 -1.1 0.3 -2.0
Smoking status: Previous 1.2 1.7 6.0 0.7 -0.4 0.9 1.2 -1.2 -1.0 1.2 0.2 0.4 -0.8 -0.7 -1.8 1.8 0.9 -2.3 -1.3 -1.8 -1.1 -2.1 -0.0 0.3 -1.7 -1.1 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.7 0.8 -0.7 0.9 -0.1 -1.0 -0.2 1.1 -0.2 -1.2 -1.3 -1.4 1.2 -0.8 0.8 -0.1 -0.7 0.8 -1.5 -1.0 1.8 1.6 -0.5 -0.6 -1.9
Whole body fat-free mass 1.2 6.9 19.1 0.4 -3.6 1.1 0.8 -3.5 -2.8 4.0 -2.4 -3.0 -3.7 -4.4 1.1 -0.6 0.2 -1.1 -3.0 0.4 -4.1 -3.1 0.5 3.4 -1.1 -3.2 -2.1
Leg fat-free mass (right) 1.4 7.6 20.0 -0.1 -4.1 0.8 0.5 -3.9 -2.2 4.2 -2.5 -3.1 -4.1 -4.1 1.0 -1.0 -0.4 -1.5 -3.4 0.2 -4.5 -3.2 0.3 3.0 -1.4 -4.0 -2.4
Arm fat percentage (left) 1.6 6.4 19.5 -1.4 -3.2 -0.0 -1.9 -3.2 -0.5 2.4 -1.4 -2.4 -3.2 -1.9 -2.1 -1.8 -1.0 -3.8 -3.9 -2.3 -3.2 -2.9 -1.5 -0.3 -2.9 -4.4 -2.4
Average weekly red wine intake 0.3 0.4 1.8 0.1 0.7 1.0 1.3 0.8 -0.6 -0.5 0.2 0.1 0.4 -0.1 -0.4 0.0 0.6 0.6 -0.7 -1.0 -0.4 -0.2 -0.6 -0.7 0.6 0.6 -0.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 4.1 0.7 0.4 0.0 0.7 0.7 0.5 0.6 -0.8 0.7 0.5 -0.1 0.4 1.1 0.4 0.2 1.5 0.5 0.8 -0.1 1.4 0.5 0.8 2.0 0.3
Mood swings 0.3 0.6 2.1 1.2 1.2 0.1 -0.7 -0.4 1.2 -0.1 -1.4 0.3 0.2 -1.0 0.2 -0.6 0.9 -0.2 0.6 1.3 -0.0 0.8 1.4 -0.4 -0.8 -0.3 0.6
Loneliness, isolation 0.6 0.8 5.5 -0.5 1.5 -0.6 -1.2 0.1 1.2 -1.6 -0.9 0.2 0.4 -0.7 -0.4 -0.0 -0.6 0.1 0.8 0.4 0.7 0.9 -0.2 -2.3 0.5 1.2 0.0
Long-standing illness, disability or infirmity 2.2 3.4 9.0 1.5 -1.0 1.5 -1.9 -3.0 -0.6 1.8 -2.2 -0.9 -1.8 -2.9 -0.6 -3.0 1.4 -2.5 -1.2 0.1 -1.7 -1.1 1.2 1.1 -2.5 -2.6 -1.9
Ever had bowel cancer screening 1.0 1.2 3.1 1.2 1.0 1.4 -0.3 -0.4 -0.8 0.6 -1.4 -0.2 -0.3 -1.3 -1.8 -0.7 1.6 -1.7 -1.3 -1.4 -0.5 -1.1 -0.3 -0.8 -1.6 -0.9 -0.7
Diabetes diagnosed by doctor 0.9 1.5 6.2 0.7 -2.1 0.9 -1.1 -1.4 0.7 1.5 -0.1 -0.6 -1.1 -0.9 -0.8 -0.8 0.1 -1.7 -1.6 -0.8 -1.1 -1.1 0.2 1.0 -1.9 -2.5 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 3.7 -0.4 -0.7 0.4 1.9 -0.5 -0.9 -0.5 0.3 0.3 -0.9 -0.2 -0.6 -0.5 -0.5 0.0 -0.5 -1.2 -0.2 -0.4 -1.4 -1.6 1.3 0.0 0.9
Friendships satisfaction 0.3 0.3 2.5 0.3 -0.3 0.5 0.6 0.0 -1.4 -0.3 0.4 0.5 0.1 -1.6 -0.4 -0.1 0.6 -0.2 -0.3 0.0 -1.0 -0.1 0.7 0.0 -0.0 -0.3 -0.1
Qualifications: nursing, teaching 0.9 1.4 4.6 1.9 -0.8 1.8 1.4 -1.7 -0.6 1.5 -0.6 -0.4 -0.9 -0.8 -0.5 0.1 1.4 -0.6 -0.7 -0.2 -1.3 -1.1 1.7 1.3 -0.7 -1.2 -2.1
Commuting to job workplace: Walk 0.4 0.4 2.7 0.2 0.7 -0.4 -0.1 0.3 1.3 -0.2 -0.2 0.6 0.3 0.7 -0.2 0.8 -0.1 -0.3 0.9 0.7 0.4 -0.1 0.7 -0.4 -0.8 -0.1 -1.6
Eye problems/disorders: Cataract 0.9 1.0 3.5 1.6 0.2 0.8 -0.7 -0.9 -0.4 1.4 1.8 -1.3 -0.5 0.6 0.9 -0.1 1.4 0.2 0.3 1.1 -0.2 -0.8 1.7 1.9 0.0 0.4 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 3.5 1.9 0.3 1.6 -0.6 -0.2 1.5 -0.3 0.6 -0.3 0.1 -0.3 -1.5 0.7 1.7 -0.9 0.4 -0.3 0.3 -1.0 1.3 -1.4 -0.3 0.3 -0.9
Medication for cholesterol 0.7 1.0 4.9 0.5 0.7 0.6 -0.5 1.8 -0.1 -0.9 2.2 -0.1 1.2 0.6 -0.1 -1.0 1.3 1.8 0.4 -0.5 -0.0 1.4 -0.2 -0.3 1.0 1.1 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 2.1 0.8 -0.0 0.9 -0.1 -0.5 -1.4 0.4 -0.9 -0.7 -0.9 -0.2 -0.3 -0.5 0.8 -0.3 -0.2 -0.7 -0.7 -0.3 0.1 0.6 -0.7 0.5 -0.0
Back pain experienced in last month 1.4 2.0 7.1 0.7 -1.0 0.7 -2.7 -2.1 -0.0 2.0 -2.0 -0.5 -1.4 -2.1 0.8 -2.2 0.5 -1.0 -0.7 0.6 -1.9 -0.9 0.8 0.6 -1.6 -1.5 -1.2
Mineral and other dietary supplements 1.2 1.6 6.9 -0.7 -0.2 -0.8 2.1 0.3 0.2 -0.4 -0.6 -0.1 0.5 0.6 2.4 1.5 -1.8 2.0 1.5 2.6 0.5 1.0 1.0 0.5 1.6 0.9 0.4
Breast cancer (self-reported) 0.7 0.8 3.3 0.2 1.5 0.2 1.8 1.5 -0.5 -1.4 0.2 0.6 1.2 0.5 -0.9 0.7 0.4 0.3 0.5 -0.7 1.2 -0.0 0.1 -0.5 -0.1 1.4 0.9
Asthma (self-reported) 1.0 2.0 5.8 1.5 -2.2 2.1 -2.4 -1.7 0.0 1.4 0.5 -0.4 -1.6 -0.3 -0.8 -2.3 1.5 -1.8 -1.3 -0.5 -1.4 -1.0 0.2 -0.6 -1.2 -1.4 -1.7
Osteoporosis (self-reported) 0.6 0.7 3.6 0.9 0.5 1.2 0.3 0.4 -1.5 -0.5 -0.3 0.1 0.3 0.6 -1.4 -1.4 1.1 -0.4 -0.9 -1.9 -0.6 -0.4 -0.8 0.5 -0.5 0.0 -0.2
Osteoarthritis (self-reported) 1.0 1.2 6.5 -0.0 0.1 0.0 0.4 -0.2 0.2 -1.1 2.5 0.2 0.2 0.9 1.1 -0.4 0.3 0.7 0.5 1.1 1.4 1.5 -1.1 -2.0 1.6 1.1 2.0
Medication: Aspirin 4.1 5.3 13.2 -0.0 -1.7 1.2 1.4 -2.7 -3.4 3.5 -1.8 -2.0 -3.1 -1.3 -1.0 -1.0 -0.2 -2.9 -3.6 -2.0 -3.1 -3.3 -0.5 2.1 -2.4 -3.3 -1.4
Medication: Gliclazide 0.4 0.5 2.8 0.2 -0.0 0.6 0.7 0.3 0.5 -1.7 0.3 -0.7 0.6 1.0 -1.6 0.3 -0.2 -0.6 -0.3 -0.8 0.0 0.0 -0.1 -1.1 -0.8 -0.6 -0.0
Illnesses of father: None of the above (group 1) 1.3 1.6 4.0 -1.8 1.0 -1.5 0.2 1.9 -0.4 -1.5 0.0 0.7 1.6 1.1 0.6 0.9 -1.4 2.0 0.8 -0.0 1.1 1.7 -1.6 -0.2 1.6 0.4 1.9
Smoking status: Current 0.5 0.7 2.5 0.4 -0.1 0.8 -0.6 0.0 0.4 0.6 0.3 -0.3 0.1 -0.2 -1.4 -0.8 -0.1 -1.1 -0.8 -0.8 -1.6 -0.7 1.3 0.3 -1.3 -1.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 3.9 -1.4 1.1 -1.5 2.0 0.9 -0.9 0.1 -0.4 -0.0 0.2 1.2 1.8 1.4 -1.2 1.7 0.3 0.5 1.2 0.4 -0.6 1.1 1.7 1.0 0.9
Whole body water mass 1.2 6.6 18.7 0.2 -3.5 0.9 0.7 -3.5 -2.6 4.0 -2.5 -3.1 -3.8 -4.3 1.3 -0.6 -0.0 -1.0 -2.9 0.5 -4.0 -2.9 0.4 3.4 -0.9 -3.2 -1.9
Leg predicted mass (right) 1.4 7.5 19.7 -0.1 -4.0 0.8 0.5 -3.9 -2.1 4.1 -2.5 -3.1 -4.1 -4.2 0.9 -1.0 -0.4 -1.5 -3.3 0.1 -4.4 -3.2 0.3 2.9 -1.4 -3.9 -2.3
Arm fat mass (left) 1.9 7.7 22.3 -1.0 -3.8 0.4 -1.1 -3.8 -1.6 3.2 -1.8 -3.1 -3.9 -2.9 -1.4 -1.9 -0.8 -3.5 -4.2 -1.8 -4.0 -3.5 -1.1 0.8 -2.8 -4.7 -2.6
Number of self-reported non-cancer illnesses 0.3 0.6 3.2 0.3 -0.9 -0.0 -1.0 -1.8 -0.1 0.6 -0.6 0.4 -1.2 -0.6 0.4 -1.0 0.3 -0.7 -0.2 0.5 0.5 0.8 -0.9 -0.5 -0.1 -1.0 0.7
Average weekly champagne plus white wine intake 0.7 0.9 5.4 1.6 -0.2 0.7 0.4 0.3 1.9 -0.1 0.7 0.5 1.0 -0.6 0.1 0.7 1.4 0.6 1.2 1.0 0.5 0.7 2.3 0.7 -0.2 0.5 0.1
Miserableness 0.6 1.0 5.4 0.9 1.8 -0.1 -0.3 -0.5 1.6 0.0 -1.2 0.2 0.2 -0.8 1.4 0.7 0.1 0.5 1.6 2.3 0.6 1.0 1.6 0.6 0.4 0.2 0.8
Guilty feelings 0.7 1.0 3.5 0.6 -0.1 1.2 -1.3 -1.4 0.0 1.2 -1.9 -1.1 -1.8 -0.7 -0.2 -1.6 0.9 -1.1 -1.0 -0.1 -1.2 -0.4 0.0 0.4 -1.0 -1.2 -0.4
Wears glasses or contact lenses 0.9 1.0 5.4 1.2 0.6 0.5 -0.5 -0.3 -0.2 -0.4 -1.3 -0.4 0.2 -1.1 0.7 2.3 1.3 0.5 1.2 1.3 1.1 0.7 1.6 1.0 0.5 1.0 -0.3
Ever taken oral contraceptive pill 0.6 0.6 2.5 -1.0 0.2 -0.5 -0.7 0.3 1.6 -0.3 -1.4 -1.0 0.1 0.3 1.2 -1.0 -1.1 0.8 0.4 0.6 0.1 0.6 -0.7 -0.1 1.0 0.5 0.7
Hearing aid user 2.1 2.4 11.2 -2.2 -0.5 -2.0 -3.3 0.5 2.0 -1.4 -2.2 -0.4 -0.1 -0.7 1.9 -0.3 -2.2 0.9 1.2 1.4 1.1 1.1 -1.4 -1.4 1.7 1.6 0.8
Mother’s age at death 0.2 0.3 1.7 0.1 -0.6 0.6 0.2 0.3 -0.4 0.2 1.3 0.2 -0.2 0.9 -0.3 -0.0 -0.1 0.6 -0.1 -0.2 -0.3 -0.3 0.2 0.3 1.2 0.4 -0.6
Financial situation satisfaction 0.4 0.5 4.9 -0.0 -0.3 0.2 -0.3 -0.4 -0.6 -0.9 -0.3 0.1 -0.0 -0.7 -1.2 -0.7 -0.2 -0.6 -0.4 -0.5 -0.2 0.6 -0.4 -2.2 -0.5 -0.1 0.3
Tinnitus: Yes, now most or all of the time 1.4 1.6 5.7 -1.4 -1.4 -1.3 -0.6 -2.2 0.2 1.7 -1.9 -1.5 -2.4 -0.2 2.0 -1.1 -2.0 -0.2 -0.1 1.7 -1.0 -0.3 -0.4 0.5 0.3 -0.1 -0.3
Commuting to job workplace: Public transport 0.4 0.4 3.0 0.0 0.4 -0.2 0.5 -0.0 0.0 0.1 1.7 0.6 -0.1 1.3 -0.5 -0.3 -0.2 -0.5 0.3 0.2 0.2 0.8 1.1 0.1 -0.9 -0.8 -0.8
Eye problems/disorders: Glaucoma 0.3 0.4 2.4 -0.1 -0.2 0.1 -0.5 -1.4 -0.9 0.8 -0.7 -0.3 -1.3 -1.6 -0.1 -0.3 0.3 -0.3 -0.2 -0.2 0.0 0.1 -0.5 0.1 0.3 -0.0 -0.0
Medication: Blood pressure 0.8 1.5 6.2 1.0 -0.5 0.9 1.8 -0.6 -1.3 1.1 -1.4 1.4 -0.0 -1.0 -1.5 0.2 0.6 -2.1 -1.1 -0.6 -0.6 -0.8 0.7 1.0 -2.5 -1.4 -1.8
Pain type(s) experienced in last month: Hip pain 1.5 1.9 6.9 -1.7 1.3 -1.7 -1.6 0.2 1.1 0.0 -1.6 0.2 0.2 -0.0 2.6 0.3 -2.4 1.8 1.9 1.6 0.8 1.4 -0.5 -0.4 1.9 1.6 1.2
Supplements: Fish oil (including cod liver oil) 0.9 1.2 4.6 0.7 -0.0 0.8 -1.8 -0.6 0.1 1.1 0.2 0.3 -0.7 -1.6 -1.6 0.6 1.3 -2.1 -1.2 -1.7 -0.2 -1.1 -1.0 -0.2 -1.4 -1.1 -0.6
High cholesterol (Self-reported) 1.0 1.8 5.1 -1.9 -1.7 -1.5 -0.5 -2.0 -2.0 1.7 -0.5 -0.1 -2.3 0.2 0.9 -1.7 -1.4 -1.4 -1.8 -0.2 -0.5 -0.9 -2.0 0.4 -0.3 -1.4 -0.1
Medication: Bendroflumethiazide 0.9 1.4 4.1 1.6 0.5 1.4 0.2 0.4 0.1 0.6 -0.6 2.0 1.1 -1.5 -1.8 0.5 2.0 -1.6 -1.1 -0.8 -0.7 -0.4 1.0 0.2 -1.7 -1.4 -1.0
Medication: Paracetamol 0.4 0.7 4.0 0.2 0.9 0.1 -2.0 0.3 0.8 -0.3 1.0 0.6 0.5 -0.0 -0.6 -1.5 1.0 -0.6 -0.1 -0.1 0.0 1.5 0.4 -0.2 -1.0 -1.1 0.3
Medication: Lisinopril 0.3 0.4 1.2 -0.1 -0.9 -0.4 -0.3 -0.8 0.4 1.1 -0.9 0.9 -0.1 -1.0 0.1 0.9 -0.5 -0.6 0.2 0.7 0.1 -0.5 0.3 0.8 -0.1 -0.5 -0.5
Medication: Atorvastatin 0.5 0.7 2.0 0.6 1.3 0.8 1.4 0.8 -0.4 -0.2 -0.5 1.1 0.6 0.9 -0.9 1.4 0.3 -0.7 -0.3 -0.6 0.4 0.2 0.5 0.8 -0.9 -0.6 -1.2
Illnesses of father: High blood pressure 2.2 2.8 9.7 2.2 -0.5 2.0 0.1 -1.3 -0.5 1.7 0.1 -0.2 -0.4 -1.3 -2.4 -0.4 2.6 -2.8 -1.4 -1.4 -1.8 -1.6 2.0 0.9 -3.1 -1.6 -1.9
Alcohol drinker status: Never 0.4 0.4 2.4 -0.8 0.1 -1.1 -0.2 -0.2 -1.5 0.2 1.6 0.7 0.1 -0.2 0.4 0.4 -0.2 0.0 -0.1 0.8 0.6 0.6 -0.6 0.5 0.6 -0.0 0.9
Ever smoked 1.1 1.9 7.5 0.8 -0.8 1.0 0.8 -1.5 -0.0 0.9 0.1 -0.9 -0.8 -0.3 -1.7 1.1 0.5 -2.3 -0.9 -1.2 -1.9 -2.0 1.7 0.4 -2.2 -1.5 -2.7
Basal metabolic rate 1.4 7.7 20.1 0.2 -3.8 1.1 0.4 -3.8 -2.6 4.1 -2.6 -3.2 -4.0 -4.5 0.7 -0.9 0.1 -1.7 -3.3 0.1 -4.4 -3.4 0.4 3.2 -1.6 -3.7 -2.4
Leg fat percentage (left) 0.8 3.0 8.8 -2.4 -1.8 -1.6 -1.7 -1.6 -0.3 1.0 -1.0 -0.8 -1.5 -1.2 -1.8 -0.9 -1.9 -2.7 -2.5 -1.9 -1.4 -1.7 -2.4 -0.9 -1.7 -3.0 -1.4
Arm fat-free mass (left) 1.1 5.4 15.5 -0.1 -3.4 0.4 0.9 -3.2 -2.9 3.6 -1.8 -2.6 -3.4 -3.9 1.4 -0.2 -0.2 -0.8 -2.5 0.6 -3.5 -2.5 0.1 3.1 -0.6 -2.9 -1.5
Number of operations (self-reported) 0.8 1.2 4.8 -0.4 0.6 -0.8 -0.2 -0.4 1.3 -0.9 -0.7 -0.8 -0.2 0.2 1.5 0.4 -1.1 1.1 2.1 1.6 1.3 1.1 0.8 -0.6 1.2 2.2 0.9
Average weekly beer plus cider intake 1.3 1.9 5.4 1.4 -0.7 1.0 -1.3 -1.8 -0.5 1.9 -1.7 -2.1 -1.5 -1.5 0.3 -0.8 0.4 -1.1 -0.3 1.5 -1.6 -1.6 2.1 2.3 -0.8 -0.9 -0.6
Irritability 0.6 1.0 3.1 -1.3 -0.9 -0.9 -0.9 -1.2 0.8 -0.0 -1.7 -1.0 -1.2 -0.7 1.1 -1.0 -1.8 0.2 -0.1 0.9 -0.2 0.2 -0.4 -0.8 0.9 -1.1 1.3
Risk taking 0.9 1.4 4.7 -0.2 -0.9 -0.4 1.6 -0.8 -1.3 1.6 -1.1 -0.2 -0.7 -1.2 1.9 0.9 -1.0 1.9 1.0 0.9 0.3 0.8 -0.4 2.2 1.6 0.0 1.4
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.9 -0.7 -0.2 -0.2 -1.3 -0.9 -1.7 1.0 -1.0 -0.2 -0.9 -1.7 -0.1 -0.3 -0.1 -0.6 -1.6 -1.0 -1.5 -1.6 -0.5 0.3 -0.2 -1.2 -0.4
Fractured/broken bones in last 5 years 1.4 1.8 11.4 -0.3 0.6 0.5 0.9 1.4 0.5 -0.7 1.1 1.8 1.1 0.9 -2.9 -0.0 0.4 -1.3 -1.4 -3.4 -0.6 0.1 -1.8 -1.7 -1.4 -0.4 0.4
Age started oral contraceptive pill 0.8 1.0 4.5 -0.1 -1.8 0.4 0.8 -1.0 -0.7 1.6 1.0 0.6 -1.0 0.5 -0.0 -1.0 0.1 -1.4 -1.3 0.0 -0.8 -0.8 -1.0 0.7 -1.2 -2.1 0.0
Diastolic blood pressure, automated reading 0.7 2.3 8.8 0.7 -0.0 0.5 2.9 -0.1 -1.7 0.7 1.4 0.9 -0.0 1.0 -3.0 1.1 1.1 -2.6 -1.8 -2.1 -1.0 -1.2 0.9 0.2 -2.1 -2.0 -1.4
Ever depressed for a whole week 0.4 0.5 2.1 -0.7 -0.5 -0.2 -0.4 -0.2 0.8 0.1 0.8 -0.7 -0.1 1.5 -0.2 0.5 -1.4 -0.3 -1.1 -0.7 -0.5 -0.5 -0.1 0.0 0.5 -1.2 -0.7
Unable to work because of sickness or disability 0.6 0.7 3.9 -0.4 1.0 -0.6 -1.4 0.5 1.0 -1.0 -2.0 -0.6 0.7 -1.9 -0.7 -0.1 -0.5 -0.5 -0.1 -0.3 0.2 0.8 0.5 -0.0 -1.0 -0.2 0.1
Commuting to job workplace: Cycle 0.4 0.4 2.7 -0.3 0.2 -1.1 -0.5 -0.7 -1.2 0.8 -0.3 0.1 -0.1 -0.9 0.3 -0.3 0.2 -0.0 -0.1 0.5 -0.4 -0.4 1.0 1.6 -0.2 -0.7 -0.5
Myopia 1.9 2.7 10.3 3.0 0.8 2.4 1.1 0.1 -1.7 -0.8 0.1 1.6 1.1 -0.9 -2.7 -0.5 3.2 -2.0 -0.1 -1.0 -0.5 -1.1 2.5 -0.7 -2.5 0.2 -1.8
Vascular/heart problems diagnosed by doctor 0.3 0.9 6.5 0.5 0.1 0.8 -0.8 0.4 0.6 -0.6 1.1 -2.6 -0.3 1.7 0.9 -0.4 0.5 1.3 0.8 0.7 -0.1 -0.3 0.7 0.0 0.9 1.5 -0.1
Cholesterol lowering medication 0.8 1.2 5.4 0.3 -0.8 0.9 0.3 -1.6 -0.9 0.6 -0.4 0.1 -1.6 0.9 -1.0 -1.2 0.4 -2.3 -2.0 -1.1 -0.6 -1.5 -0.6 -0.6 -1.1 -1.3 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 5.8 2.4 0.2 1.8 0.6 -0.4 -0.6 0.2 1.1 0.4 0.2 -1.0 -0.5 0.8 2.4 -0.5 0.1 0.7 -0.2 0.0 1.5 0.9 -0.3 -0.0 -0.3
Pain experienced in last month 0.7 1.2 6.0 -0.8 -1.2 -0.1 2.4 0.2 -1.5 -0.8 2.4 -0.7 -0.1 1.9 -0.8 -0.1 -0.5 -0.8 -1.5 -1.2 -0.4 -0.6 -0.4 -0.2 -0.2 -1.0 -0.5
Supplements: Calcium 1.3 1.5 7.1 2.1 0.7 1.4 0.5 1.7 0.6 -0.5 0.4 2.7 2.0 -0.8 -1.9 -0.3 2.3 -0.1 -0.1 -1.6 0.4 0.3 0.4 0.2 -0.7 0.6 -0.1
Basal cell carcinoma (self-reported) 0.3 0.4 1.9 -0.0 0.2 0.6 0.4 0.6 -0.4 -0.6 0.3 -0.4 0.2 -0.3 -0.7 -0.1 0.8 -0.5 -0.7 -1.4 -0.1 -0.3 -1.0 -0.9 -1.2 -0.2 0.9
Heart attack/myocardial infarction (self-reported) 2.1 2.7 8.8 0.1 -2.6 0.7 0.0 -2.1 -1.8 3.0 -1.5 -1.4 -2.2 -0.6 0.3 -0.9 -0.1 -1.5 -2.1 -0.7 -2.5 -1.7 0.3 2.0 -1.6 -2.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 13.6 -0.2 -0.0 -0.8 -3.7 -0.3 1.7 0.2 -2.0 -0.9 -0.1 -0.9 0.6 -1.5 -0.5 0.3 -0.1 0.2 -0.6 -0.2 -0.0 0.5 -0.6 -0.6 -0.3
Heart disease (siblings) 0.6 0.7 3.4 -1.5 -0.6 -0.9 -0.8 -0.7 -0.2 -0.9 -0.2 -0.9 -0.7 1.3 0.2 -1.8 -1.5 -0.2 -0.2 -0.1 0.3 -0.1 -1.1 -0.8 -0.2 0.1 -0.7
Alcohol drinker status: Previous 0.6 0.7 3.4 -0.4 0.1 -0.9 -1.4 0.3 1.9 -0.5 -1.1 0.8 0.8 -1.7 -0.4 0.5 -0.8 -0.4 0.5 0.3 0.3 -0.3 0.7 -1.0 -0.3 -0.1 -0.6
Pack years of smoking 0.8 1.2 5.1 0.4 -1.4 0.3 -1.3 -1.4 -0.3 1.1 -2.2 -1.1 -1.0 -1.6 0.7 -1.4 -0.0 -0.7 -0.1 0.9 -1.6 -0.1 0.7 1.2 -1.2 -1.3 0.3
Impedance of whole body 0.6 3.1 11.0 3.3 0.9 3.2 -0.6 0.6 -0.1 -0.2 0.1 0.4 1.0 0.3 -2.9 -1.4 3.2 -2.3 -0.4 -2.0 -1.0 -1.0 2.5 0.2 -2.8 0.3 -1.9
Leg fat mass (left) 1.0 4.1 11.6 -1.7 -2.8 -0.7 -1.2 -2.6 -1.2 2.2 -1.3 -2.0 -2.7 -2.2 -1.0 -1.1 -1.5 -2.6 -3.0 -1.3 -2.6 -2.3 -1.9 0.3 -1.6 -3.4 -1.6
Arm predicted mass (left) 1.1 5.4 13.5 -0.2 -3.5 0.4 0.9 -3.1 -3.0 3.5 -1.8 -2.6 -3.4 -3.7 1.2 -0.4 -0.3 -0.9 -2.7 0.3 -3.6 -2.7 -0.2 3.0 -0.7 -2.9 -1.6