Hub : Genes

BHMT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3270	0.0500	0.0e+00	0.335	0.299	0.369	0.386	0.377	4.6e-42	7.3e-37	3.2e-47	7.6e-50	2.5e-48
2	ROSMAP	Brain Pre-frontal Cortex	0.1707	0.0398	0.0e+00	0.182	0.180	0.203	0.208	0.197	8.4e-23	1.4e-22	1.6e-25	3.1e-26	9.7e-25
3	TCGA	Breast Invasive Carcinoma	0.0459	0.0235	7.7e-07	0.022	0.041	0.038	NA	0.035	2.0e-05	8.2e-09	2.1e-08	NA	9.2e-08
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.2774	0.0757	2.0e-15	0.149	0.156	0.160	NA	0.159	1.8e-16	3.6e-17	1.2e-17	NA	1.9e-17
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1780	0.0579	2.9e-10	0.044	0.090	0.073	NA	0.085	9.5e-06	2.6e-10	1.3e-08	NA	8.9e-10
6	TCGA	Brain Lower Grade Glioma	0.0407	0.0212	9.5e-05	0.036	0.016	0.019	NA	-0.001	5.4e-05	5.9e-03	2.4e-03	NA	5.4e-01
7	TCGA	Lung Squamous Cell Carcinoma	0.2505	0.0923	4.2e-10	0.111	0.101	0.106	NA	0.102	1.6e-12	1.8e-11	4.7e-12	NA	1.1e-11
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.1240	0.0550	5.1e-05	0.076	0.088	0.093	NA	0.077	7.3e-06	1.5e-06	7.8e-07	NA	6.8e-06
9	TCGA	Prostate Adenocarcinoma	0.0404	0.0264	2.5e-03	0.030	0.000	0.008	NA	0.015	3.5e-04	3.0e-01	4.6e-02	NA	8.6e-03
10	TCGA	Testicular Germ Cell Tumors	0.2680	0.1060	9.6e-05	0.218	0.154	0.173	NA	0.211	3.1e-08	4.2e-06	1.1e-06	NA	5.5e-08
11	TCGA	Thyroid Carcinoma	0.0470	0.0250	6.6e-05	0.029	0.039	0.032	NA	0.032	7.0e-04	9.8e-05	4.4e-04	NA	4.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.1	3.1	0.1	-0.5	-1.4	-1.1	1.8	-1.0	-0.6	-1.3	-0.7	-0.4	-1.2
Bipolar Disorder or Schizophrenia	0.6	1.4	4.1	2.0	1.7	0.5	-0.9	1.7	1.4	-0.3	-0.2	0.9	-0.9	1.0
Depressed Affect (Nagel 2018)	1.8	3.8	6.6	-0.4	-1.5	-2.0	-2.2	1.1	-2.1	-2.6	-1.2	-2.5	-2.5	-2.1
Depression (Nagel 2018)	1.4	2.1	5.9	-0.2	-1.6	-1.5	-1.2	0.5	-1.2	-1.5	-1.2	-1.0	-2.3	-2.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.9	1.2	0.5	0.4	-0.4	1.4	0.7	0.6	0.1	0.1	0.1	0.8
Neuroticism (Nagel 2018)	0.6	1.4	3.9	-0.3	-0.7	-0.9	-1.5	0.5	-1.1	-2.0	-0.5	-1.5	-1.9	-1.0
Schizophrenia (2018)	1.5	3.0	7.0	2.6	2.6	1.8	-0.3	0.8	2.6	0.1	0.8	1.7	-0.9	2.2
Schizophrenia vs Biploar Disorder	2.3	3.0	6.7	2.2	2.6	1.4	1.3	-0.4	2.0	1.8	1.1	1.7	1.1	2.3
Worry (Nagel 2018)	0.2	0.5	1.3	0.6	1.0	1.1	-0.2	0.2	0.9	-0.4	0.8	0.2	-0.2	1.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-0.8	-0.2	-0.9	-0.2	-0.3	-1.0	-0.2	-0.6	-0.8	-0.4	-1.1
Alzheimer’s Disease (in father)	0.9	0.9	2.1	1.1	1.1	-1.1	-1.2	1.4	0.2	-0.3	-1.0	0.0	-1.4	-0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	3.2	-0.2	0.1	-1.6	-0.9	0.1	-1.1	-1.0	-1.2	-0.9	-1.5	-1.8
Crohns Disease (2017)	0.2	0.4	1.8	0.4	0.3	-0.6	-1.0	0.5	0.1	-0.5	-0.6	0.0	-1.4	-0.7
Irritable Bowel Disease (IBD)	0.4	1.1	2.2	-0.6	-0.7	-1.2	-1.5	1.2	-0.4	-1.0	-1.4	0.2	-1.2	-1.1
Ulcerative Colitis (UC)	0.6	1.1	2.3	-1.1	-1.2	-1.4	-1.1	1.2	-0.7	-0.8	-1.5	0.1	-0.5	-1.2
Major Depression (MDD)	3.2	3.9	9.6	-0.1	-0.9	-2.4	-1.7	-0.3	-2.6	-1.5	-1.5	-2.7	-2.4	-3.1
Reaction Time	0.2	0.4	1.4	0.3	0.3	0.8	0.3	0.2	1.0	0.0	0.6	0.7	0.4	1.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.7	-0.5	-0.4	0.7	-0.2	0.7	0.8	0.3	0.2	1.0	0.6	1.3
Breast Cancer	0.8	2.0	4.0	-0.2	-1.2	-1.8	-1.6	0.9	-0.7	-2.0	-2.0	-0.0	-1.8	-1.6
Ovarian Cancer	1.2	1.6	3.1	0.3	0.3	1.4	1.8	-1.5	1.5	1.1	1.3	1.5	1.4	0.9
Prostate Cancer	0.2	0.3	0.7	0.8	0.7	-0.4	0.4	-0.3	-0.2	0.9	0.1	-0.6	0.1	-0.3
Age at First Birth	0.5	0.8	1.9	0.6	0.8	0.8	0.7	-0.0	0.4	1.3	1.1	-0.2	1.4	1.1
Bipolar Disorder (2011)	0.5	0.5	1.7	0.4	-0.1	-1.3	-0.1	1.0	-0.8	0.2	-0.8	-0.7	0.4	-0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-1.0	-0.8	0.6	0.7	-0.5	0.1	0.1	0.5	0.3	0.8	0.3
Coronary Artery Disease (CAD)	0.7	0.9	4.4	0.5	0.6	0.8	-0.3	0.4	1.4	0.9	-0.1	2.1	-0.0	1.1
Crohns Disease (2012)	0.2	0.4	1.4	0.4	0.6	0.1	-1.1	1.2	0.5	-0.4	-0.1	0.3	-0.7	-0.0
Mean Putamen Volume	1.9	2.2	3.9	-0.7	-1.5	-1.9	-1.1	0.8	-1.7	-1.5	-1.7	-1.4	-1.2	-2.0
Fasting Glucose	2.2	2.7	7.9	-0.7	-1.2	-2.8	-1.2	0.5	-2.2	-1.4	-1.7	-1.5	-1.2	-2.1
HbA1C	0.3	0.3	0.7	0.4	0.5	0.8	0.4	0.5	0.8	0.1	0.5	-0.4	0.4	0.9
HDL Cholesterol	3.3	5.5	9.4	1.7	2.8	2.5	1.9	-0.5	2.7	3.0	2.1	2.3	2.1	3.1
LDL Cholesterol	2.3	3.6	7.3	2.7	2.4	1.6	1.2	0.9	2.3	1.9	1.1	2.0	1.8	2.1
Lupus	1.2	1.9	8.3	2.9	1.9	-0.6	-0.5	1.5	1.5	-0.1	-1.1	1.2	-0.8	0.4
Neuroticism (2016)	1.7	2.4	5.2	0.4	-1.4	-1.9	-1.2	1.6	-1.4	-1.2	-1.7	-1.4	-1.8	-2.3
Primary Biliary Cirrhosis	3.2	4.6	12.8	1.7	0.0	-2.2	-2.8	3.6	0.1	-1.5	-3.3	1.0	-2.4	-1.6
Rheumatoid Arthritis	0.4	0.5	1.8	0.6	1.3	-0.2	-0.7	0.7	-0.4	0.1	0.1	-1.4	-0.6	0.3
Schizophrenia (2014)	1.5	3.4	11.2	3.4	3.1	1.2	-0.2	1.2	2.5	-0.1	0.2	1.9	-0.7	1.7
Triglycerides	0.2	0.3	1.2	0.6	-0.3	-0.8	-0.3	-0.0	-0.4	-0.5	-0.4	-0.1	-0.6	-1.1
Type 2 Diabetes (T2D) (2012)	3.2	3.7	7.8	-0.9	-1.5	-2.3	-2.1	0.9	-2.0	-1.7	-1.6	-2.2	-2.5	-2.8
Ulcerative Colitis	0.6	0.9	2.7	-0.5	-0.8	-0.9	-1.0	1.5	-0.6	-0.6	-1.0	-0.1	-0.5	-1.6
Blood Eosinophil Count	0.1	0.9	2.3	-0.3	0.5	1.4	1.4	-0.2	0.3	1.5	1.1	0.4	1.5	0.4
Blood Platelet Count	0.6	6.6	15.2	2.7	2.6	3.1	1.5	0.1	3.5	2.3	2.1	2.4	2.0	3.9
Blood Red Count	0.0	0.5	1.3	-1.1	-1.0	-0.1	-0.7	0.3	-0.9	-0.4	-0.5	-0.2	-0.5	-0.8
Blood White Count	1.2	8.6	20.7	-3.4	-4.5	-2.9	-0.6	-1.2	-4.4	-1.0	-1.3	-3.2	-0.9	-4.5
Heel T-Score	0.8	6.0	16.1	-0.2	-2.9	-3.2	-1.6	0.3	-3.1	-1.5	-2.2	-2.4	-2.4	-4.0
BMI	0.5	2.8	8.4	-1.8	-2.9	-1.2	-0.3	0.2	-2.4	-1.0	-0.9	-1.5	-0.7	-2.6
Height	1.0	19.7	42.8	-6.5	-5.7	-3.8	-3.0	-1.3	-6.0	-4.7	-2.3	-4.7	-2.8	-4.8
Waist Hip Ratio (WHR)	0.0	0.2	0.6	0.1	0.3	-0.0	-0.2	0.5	0.3	0.8	-0.4	0.6	-0.0	-0.1
Systolic Blood Pressure	0.4	1.8	5.6	0.1	-0.4	-1.7	-1.8	1.5	-0.1	-1.5	-2.4	0.3	-1.7	-0.8
Smoking Status	1.7	4.1	8.8	-3.0	-2.8	-2.0	-1.3	0.0	-2.5	-1.8	-1.6	-1.9	-1.2	-2.4
Allergy or Eczema	0.3	0.8	2.3	-0.3	-1.0	-0.7	-0.0	-0.9	-1.2	-1.0	0.0	-1.3	-0.4	-1.5
Cardiovascular Disease	0.7	2.2	5.0	-0.6	-1.3	-1.5	-1.9	2.2	-0.3	-1.2	-2.2	0.5	-1.8	-1.3
Hypothyroidism (self reported)	0.1	0.1	0.3	0.3	-0.5	-0.1	-0.3	0.3	-0.0	-0.3	-0.2	0.4	-0.6	-0.4
Respiratory disease	2.8	6.3	15.1	-0.2	-1.7	-2.7	-2.5	2.1	-2.4	-2.5	-2.4	-2.6	-3.1	-3.9
Type 2 Diabetes (T2D) (2018)	5.4	10.2	22.4	-2.8	-3.3	-4.0	-1.9	0.2	-4.5	-1.9	-2.4	-4.1	-2.2	-4.7
Lung FEV1/FVC ratio	0.1	0.4	1.6	-0.4	-0.8	0.0	0.5	0.1	-0.4	1.3	-0.3	0.3	1.1	0.8
Lung FVC	2.1	10.9	27.6	1.9	3.2	3.8	2.7	-0.9	3.4	3.2	2.9	2.9	4.1	5.3
Neuroticism	0.6	1.6	4.4	0.7	-0.1	-1.3	-1.8	1.3	-0.9	-1.1	-1.1	-1.2	-2.1	-0.9
Chronotype (morning person)	0.1	0.2	0.7	0.3	0.6	0.8	0.2	-0.2	0.3	0.8	0.5	0.3	-0.1	0.3
Hair Pigment	0.0	0.1	0.2	-0.2	-0.3	-0.4	0.1	-0.1	-0.2	0.1	-0.1	-0.2	-0.0	-0.5
Tanning	0.2	2.6	7.2	-1.0	-1.6	-0.7	-2.3	1.3	-0.3	-2.7	-1.5	0.3	-2.5	-1.0
Hand grip strength (left)	0.7	1.9	4.8	-1.3	-0.8	1.0	1.8	-2.2	-0.6	1.2	1.5	-0.4	2.1	0.8
Number of treatments/medications taken	1.4	2.5	5.6	-1.0	-1.7	-2.2	-1.1	1.1	-1.4	-1.2	-1.9	-1.1	-1.8	-2.4
Average weekly spirits intake	2.8	3.4	8.3	-2.1	-2.4	-1.8	-0.1	-0.9	-2.9	-1.2	-0.5	-2.8	0.1	-2.4
Sensitivity / hurt feelings	0.6	1.0	3.1	0.2	-0.3	-1.4	-1.1	0.1	-0.8	-1.8	-1.1	-0.7	-1.2	-0.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.0	-0.3	-1.2	-1.6	-1.0	0.6	-1.3	-1.3	-1.1	-1.4	-1.8	-2.0
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.3	-0.5	-0.2	-0.4	0.8	-0.7	-0.5	-0.2	-0.9	-0.3	-0.7
Relative age of first facial hair	0.3	0.6	1.5	-0.8	-0.2	0.0	-0.9	1.2	0.6	-0.7	-1.0	1.1	-0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.0	0.6	-0.1	-0.7	-1.0	1.2	0.2	-1.7	-1.0	-0.3	-1.7	-1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.1	0.5	-0.2	-1.1	-0.3	1.3	-0.1	-0.7	-1.2	-0.5	-0.8	-1.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	1.3	0.6	-0.9	-1.1	1.1	-0.1	-0.7	-1.1	-0.1	-1.3	-1.2
Systolic blood pressure, automated reading	1.0	2.9	7.2	0.8	-0.0	-1.7	-2.4	2.4	0.1	-2.1	-2.7	0.5	-2.1	-1.1
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	6.7	-2.2	-1.9	-2.2	-0.6	-1.1	-2.6	-1.8	-1.3	-2.5	-1.0	-2.0
Angina	0.1	0.2	0.5	-0.7	-0.1	-0.0	-0.2	0.4	-0.4	-0.7	-0.3	-0.4	-0.3	-0.1
Medication for hormone replacement therapy	0.7	0.8	1.8	0.4	-0.8	-1.0	-0.5	1.0	-0.5	-0.7	-0.8	-1.1	-1.1	-1.3
Vitamin and mineral supplements	1.4	1.9	4.6	-1.0	0.0	2.1	1.4	-1.6	0.5	0.5	1.9	0.6	1.8	1.8
Supplements: Zinc	0.8	0.8	4.4	-1.3	-2.1	0.1	-0.2	0.1	-1.0	-0.4	0.2	-1.0	-0.4	-1.0
Medication: Co-codamol	0.7	0.8	2.3	-1.4	-1.5	-0.5	-0.6	0.6	-0.7	-0.6	-0.6	-0.5	-0.8	-1.0
Medication: Metformin	2.9	4.1	10.4	-0.6	-1.8	-3.0	-1.2	0.6	-2.0	-1.7	-2.5	-1.7	-2.0	-3.2
Diabetes (father)	0.4	0.5	1.1	-0.2	-0.1	-0.6	-0.6	0.2	-0.6	-0.9	-0.3	-1.1	-1.0	-1.0
Diabetes (mother)	4.2	5.3	15.1	-3.1	-3.9	-1.3	-1.5	-0.1	-2.1	-2.9	-1.5	-1.3	-2.3	-2.8
Severe depression (siblings)	2.3	2.6	5.3	-1.4	-2.3	-1.5	-1.2	1.3	-1.8	-1.2	-1.2	-1.9	-1.3	-2.0
Pack years adult smoking proportion	0.5	0.7	2.5	0.2	-0.6	-0.6	-0.8	1.2	-0.6	-0.7	-0.6	-0.7	-0.9	-1.6
Impedance of leg (right)	0.1	0.6	1.7	0.9	1.3	0.7	0.4	0.1	1.1	0.9	0.7	0.5	0.3	0.9
Leg fat-free mass (left)	1.7	8.8	18.7	-4.1	-4.3	-2.4	-1.3	-1.2	-4.2	-2.7	-1.4	-3.2	-1.6	-3.6
Trunk fat percentage	1.1	4.6	11.8	-2.4	-2.9	-2.0	-0.8	0.0	-3.0	-1.4	-1.4	-2.2	-1.3	-3.4
Hand grip strength (right)	0.6	1.8	5.4	-1.1	-0.4	0.9	1.8	-1.8	-0.5	1.4	1.5	-0.3	2.3	0.9
Townsend deprivation index at recruitment	1.6	2.2	5.0	-0.4	-1.5	-1.4	-1.3	1.8	-1.0	-1.3	-1.5	-1.3	-1.9	-2.2
Current tobacco smoking	2.4	3.9	10.6	-1.5	-2.1	-2.4	-1.2	0.4	-2.5	-1.4	-1.5	-2.4	-1.5	-3.3
Average weekly fortified wine intake	0.3	0.3	1.0	-0.3	-0.8	-0.0	-0.7	-0.3	-0.7	-1.0	-0.1	-0.6	-0.5	-0.3
Maternal smoking around birth	0.1	0.1	0.6	-0.3	-0.1	-0.1	0.0	-0.3	-0.2	-0.2	0.3	-0.6	-0.3	-0.8
Fed-up feelings	1.3	2.3	7.5	-0.5	-1.3	-1.2	-0.6	-1.0	-2.4	-1.5	0.2	-2.7	-1.4	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.7	10.8	-1.6	-2.9	-2.1	-1.4	0.2	-2.6	-2.2	-1.4	-2.1	-2.3	-3.3
Relative age voice broke	2.4	3.6	8.1	-2.1	-2.3	-2.0	-1.0	-0.0	-2.7	-1.7	-1.4	-2.0	-0.7	-2.9
Taking other prescription medications	1.0	1.6	3.9	-1.2	-1.7	-1.4	-0.6	-0.3	-1.5	-0.9	-0.7	-1.3	-1.3	-2.0
Age when periods started (menarche)	0.7	1.6	3.6	-0.2	-0.2	1.1	1.6	-0.8	0.9	1.4	0.5	1.7	1.9	1.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.1	-0.6	-0.2	0.4	0.4	0.1	-0.3	-0.5	0.5	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.9	-0.7	-1.9	-0.6	0.2	-1.2	-2.0	0.2	0.4	-1.6	-0.2	-1.7
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.3	-1.4	-0.8	0.8	1.3	-0.6	-0.9	1.1	1.4	-1.1	1.8	0.3
Qualifications: CSEs or equivalent	1.1	1.5	4.1	-0.2	0.3	1.4	1.4	-0.3	0.7	2.0	1.1	1.2	1.8	1.2
Serious illness, injury or assault to yourself	0.5	0.6	2.0	-1.4	-0.4	0.8	0.5	-1.2	0.6	-0.3	0.5	0.8	-0.1	0.5
High blood pressure	0.4	1.1	2.9	0.1	-0.4	-1.2	-1.5	1.7	-0.2	-1.1	-1.5	0.0	-1.1	-0.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.3	-0.8	-0.9	-0.0	0.8	-1.8	-1.3	-0.1	0.9	-1.5	0.3	-1.0
Multivitamins +/- minerals	0.6	0.8	2.2	-0.4	-0.9	-1.5	-0.2	0.2	-1.1	-0.2	-0.8	-1.2	-0.2	-1.5
Stomach or abdominal pain in last month	0.8	1.0	2.5	-0.8	-1.3	-0.6	-1.0	0.2	-1.5	-1.2	-0.2	-1.6	-0.9	-0.8
Supplements: Glucosamine	0.6	0.8	3.7	-0.3	-0.4	-0.5	-1.1	1.9	-0.1	-0.6	-1.4	0.2	-1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	3.7	-0.7	-1.4	-1.3	-1.4	0.6	-0.9	-1.6	-1.2	-0.7	-1.9	-1.3
Medication: Atenolol	0.4	0.5	2.3	-1.5	-0.7	0.5	0.2	-0.3	-0.4	0.8	0.4	-0.0	0.6	0.9
Medication: Levothyroxine sodium	0.2	0.3	0.8	0.6	0.1	-0.5	-0.8	0.5	0.3	-0.7	-0.6	0.4	-0.9	-0.5
Sitting height	1.5	11.0	27.6	-4.7	-4.1	-2.5	-0.6	-2.9	-5.2	-1.7	-0.3	-4.6	-0.5	-3.9
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	-0.1	0.0	-0.7	-1.1	0.6	-0.1	-0.9	-1.0	0.4	-0.6	-0.2
High blood pressure (mother)	0.2	0.2	1.1	0.2	0.4	0.1	-1.0	-0.1	0.3	-0.3	0.2	0.3	-1.0	0.4
Body mass index (BMI)	0.6	2.6	6.7	-0.9	-1.7	-1.8	-1.2	0.7	-2.0	-1.4	-1.6	-1.3	-1.6	-2.6
Impedance of leg (left)	0.4	1.8	3.2	0.9	1.6	1.5	1.2	-0.5	1.4	1.8	1.4	1.0	1.2	1.7
Leg predicted mass (left)	1.8	9.3	19.6	-4.2	-4.4	-2.5	-1.3	-1.3	-4.3	-2.8	-1.4	-3.3	-1.6	-3.7
Trunk fat mass	1.5	6.4	14.5	-3.0	-3.4	-2.3	-1.2	-0.1	-3.5	-1.9	-1.6	-2.7	-1.6	-3.8
Waist circumference	1.0	3.5	7.7	-1.3	-1.9	-2.2	-1.8	0.9	-2.1	-1.7	-2.1	-1.1	-2.0	-2.8
Number of incorrect matches in round	0.7	1.2	6.3	-1.1	-0.7	0.1	1.3	-2.5	-0.9	0.4	0.9	-0.5	0.8	-0.6
Past tobacco smoking	0.7	1.2	3.9	2.0	1.4	0.7	0.9	-1.0	0.6	1.6	1.1	0.9	0.6	0.0
Alcohol usually taken with meals	2.4	3.8	7.6	-1.2	-0.6	2.1	2.5	-2.8	0.6	1.5	2.4	0.7	2.6	2.5
Nervous feelings	0.1	0.3	1.5	-0.2	0.2	0.1	-0.2	-0.4	-0.5	-0.9	0.4	-1.2	-0.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.4	-0.2	-1.0	-0.4	-0.7	0.8	-0.2	-1.5	-0.6	-0.4	-1.2	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	3.0	-1.0	-0.5	0.7	1.3	-1.7	-0.9	0.8	1.1	-0.8	1.1	0.1
Hair/balding pattern: Pattern 2	1.2	1.5	2.9	-0.2	-0.9	-1.5	-1.2	0.4	-1.0	-1.7	-1.6	-1.1	-1.6	-1.4
Had menopause	1.5	1.8	4.4	2.1	1.8	0.2	-0.9	1.3	1.8	0.0	-1.1	2.0	-1.0	0.7
Had other major operations	1.2	1.4	3.8	1.6	1.2	0.2	-0.6	1.5	1.9	-0.7	-0.9	1.8	-0.6	0.7
Forced vital capacity (FVC)	0.9	3.3	7.8	-1.4	-0.0	2.1	1.8	-2.7	0.2	1.2	2.3	0.3	2.8	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	-0.1	-1.2	-0.0	0.9	-1.5	-1.1	1.0	0.8	-0.8	0.4	-1.1
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.7	-1.4	-1.7	-1.3	-0.7	0.0	-1.9	-1.4	-0.8	-1.9	-1.0	-1.9
Qualifications: None of the above	1.3	2.7	4.8	2.1	1.5	-0.8	-2.1	2.0	1.4	-2.2	-1.4	1.0	-2.1	0.2
Financial difficulties in last 2 years	0.7	0.9	2.7	0.9	0.2	-1.0	-1.2	1.0	-0.2	-0.8	-0.9	-0.7	-1.6	-0.9
Mouth/teeth dental problems	1.4	2.2	4.2	-1.4	-0.5	1.4	2.0	-2.0	0.4	1.6	1.5	1.1	2.1	1.1
Heart attack	0.8	1.0	2.3	-1.5	-1.5	0.2	1.1	-0.5	-1.3	0.7	0.5	-1.1	1.1	-0.4
Allergy	0.9	2.0	5.3	0.7	1.2	1.1	0.5	0.9	1.9	1.5	0.1	2.3	1.4	2.2
Pain all over the body in last month	1.1	1.1	3.0	-0.9	-0.8	-0.8	-1.5	0.7	-0.6	-1.4	-1.1	-0.2	-1.7	-1.0
Diabetes (self-reported)	2.9	4.4	7.9	-1.2	-1.5	-2.8	-1.9	0.2	-2.4	-2.2	-2.3	-2.1	-2.4	-2.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.5	0.1	-0.2	-0.5	0.7	-1.6	-1.0	0.3	0.5	-0.9	0.3	-0.6
Medication: Ramipril	0.2	0.2	0.6	-0.8	-0.4	0.1	-0.6	0.1	-0.3	-0.4	-0.0	-0.5	-0.7	0.3
Medication: Simvastatin	0.3	0.4	1.0	-0.6	-1.0	-0.3	-0.4	0.7	-0.5	-0.6	-0.3	-0.4	-0.6	-0.9
Fluid intelligence score	0.2	0.4	1.3	-1.0	-1.1	0.0	-0.5	1.1	-0.4	0.2	-0.1	-0.4	0.3	-0.2
Illnesses of siblings	3.6	5.1	9.5	0.8	1.9	2.7	3.1	-1.6	1.6	2.6	2.6	0.9	3.0	2.5
Neuroticism score	0.7	1.4	3.3	-0.2	-0.9	-1.0	-1.3	0.8	-1.2	-1.6	-0.6	-1.6	-1.8	-1.2
Weight	1.5	7.2	14.1	-3.0	-3.6	-2.4	-1.6	-0.2	-3.7	-2.4	-1.7	-2.8	-2.0	-3.8
Impedance of arm (right)	0.1	0.6	1.3	-1.1	-1.1	0.3	1.1	-0.6	-0.4	0.4	0.8	-1.0	0.5	-0.6
Arm fat percentage (right)	1.1	4.4	11.9	-1.4	-2.5	-2.3	-1.3	1.0	-2.5	-1.8	-2.0	-1.8	-1.9	-3.4
Trunk fat-free mass	0.9	5.2	10.0	-2.9	-3.1	-2.0	-1.6	-0.8	-3.2	-2.6	-1.4	-2.2	-1.7	-2.5
Hip circumference	1.3	5.5	10.8	-2.7	-3.1	-2.3	-1.3	-0.5	-3.3	-2.0	-1.5	-2.2	-1.8	-3.3
Time employed in main current job	0.9	1.0	3.1	1.2	0.2	-1.0	-1.3	1.8	0.1	-0.3	-1.3	0.1	-1.2	-0.1
Alcohol intake versus 10 years previously	0.5	0.8	2.9	1.0	1.2	-0.7	0.2	0.5	-0.9	0.7	-0.0	-1.7	0.3	-0.9
Father’s age at death	0.3	0.5	1.2	1.1	0.9	-0.9	-0.6	1.0	0.2	-0.4	-0.7	-0.3	-0.4	-0.1
Worrier / anxious feelings	1.0	1.8	3.2	1.7	1.6	0.2	-1.4	1.7	1.8	-0.6	-0.8	1.5	-1.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	8.5	0.5	-0.2	-1.9	-2.3	1.6	-1.2	-1.9	-1.8	-1.6	-2.9	-2.0
Falls in the last year	0.4	0.6	2.5	-1.6	-1.4	-0.4	-0.3	-0.0	-0.3	-0.6	-0.9	0.4	-0.3	-0.0
Hair/balding pattern: Pattern 3	1.8	2.7	6.4	2.0	2.5	1.2	0.9	0.4	1.7	1.7	1.0	1.5	1.4	2.4
Number of live births	0.5	0.7	1.7	1.3	1.2	0.8	-0.4	0.6	1.2	-0.2	0.1	1.1	-0.3	0.6
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	9.0	-0.8	0.2	2.2	2.2	-2.6	0.5	2.2	2.5	0.7	3.0	2.6
Pulse rate	0.3	0.4	1.6	-0.2	-1.2	-0.7	0.3	-0.3	-0.6	0.1	-0.8	0.2	-0.2	-1.3
Happiness	0.1	0.1	0.7	0.1	-0.1	-0.3	-0.4	-0.5	-0.0	-0.8	-0.3	0.2	-0.5	-0.0
Noisy workplace	0.2	0.3	0.6	-0.7	-0.8	0.3	0.4	-0.1	-0.6	0.1	0.4	-0.6	0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	-0.1	0.1	0.5	0.6	-0.5	0.4	0.5	0.4	0.2	0.7	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-0.2	-0.1	1.2	0.8	-0.1	1.1	0.6	0.8	1.3	0.7	1.3
Mouth/teeth dental problems: Dentures	0.7	1.1	3.9	-0.3	-1.2	-1.1	-0.5	0.2	-1.2	-1.3	-0.7	-1.2	-0.8	-2.0
Asthma	1.6	3.2	8.0	0.3	-0.4	-1.8	-2.1	1.5	-1.1	-2.0	-1.8	-1.2	-2.8	-2.6
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	7.9	-0.8	-1.7	-2.8	-1.9	1.1	-2.3	-1.6	-2.5	-1.6	-1.9	-2.6
Medication: Cholesterol lowering	1.0	1.6	6.7	-2.2	-2.6	-0.6	0.2	-0.5	-1.6	-0.4	-0.1	-0.9	-0.1	-1.4
Depression (self-reported)	2.2	2.6	6.2	-1.4	-2.3	-1.9	-0.8	0.3	-1.8	-1.3	-1.1	-1.5	-1.4	-2.5
Medication: Lansoprazole	0.2	0.2	1.3	1.1	0.8	-0.2	-0.2	0.2	0.2	-0.6	-0.1	-0.1	-0.4	-0.2
Prospective memory result	1.3	1.6	3.6	0.4	0.8	1.2	1.9	-0.7	1.3	1.5	1.2	1.1	1.7	1.4
Lung cancer (father)	0.4	0.4	2.1	1.5	0.7	0.3	0.4	0.8	0.4	0.9	0.4	-0.1	0.1	-0.3
Illnesses of mother	1.0	1.2	5.2	0.2	-0.2	0.5	1.9	-0.7	-0.6	1.2	1.1	-0.7	2.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	10.1	-1.4	-0.4	1.9	2.4	-2.6	-0.2	1.9	2.6	-0.2	3.2	2.0
Pulse wave Arterial Stiffness index	1.4	1.6	4.0	0.5	-0.4	-2.0	-0.8	1.6	-1.4	0.2	-1.8	-0.9	-0.7	-1.9
Impedance of arm (left)	0.1	0.6	1.9	-1.4	-1.2	0.4	0.7	-0.5	-0.4	0.1	0.7	-1.0	0.3	-0.7
Arm fat mass (right)	1.2	4.9	11.7	-2.1	-2.9	-2.0	-1.3	0.3	-3.0	-1.9	-1.6	-2.2	-1.8	-3.4
Trunk predicted mass	1.0	5.4	10.7	-3.0	-3.1	-2.0	-1.6	-0.9	-3.3	-2.6	-1.4	-2.3	-1.6	-2.6
Standing height	0.9	8.8	26.7	-5.2	-4.5	-1.2	-0.6	-2.6	-4.1	-2.2	0.1	-3.4	-0.6	-2.7
Length of working week for main job	1.0	1.1	4.2	-0.7	-0.2	-1.0	0.4	-1.4	-1.7	0.2	0.6	-2.1	0.6	-0.6
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.5	0.5	0.1	0.6	-0.5	0.1	0.4	0.4	-0.1	0.3	0.0
Breastfed as a baby	0.4	0.6	1.3	0.9	1.1	0.0	-0.7	0.9	0.8	-0.9	-0.7	0.5	-0.4	0.6
Tense / ‘highly strung’	0.2	0.4	1.3	-0.1	-0.2	1.1	0.1	-0.6	0.8	-0.6	0.6	0.7	-0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	7.1	-1.3	-2.4	-1.4	-1.0	-0.1	-2.4	-2.2	-0.6	-2.7	-1.8	-2.6
Hair/balding pattern: Pattern 4	0.4	1.0	3.4	1.8	1.7	-0.4	-0.8	1.1	0.9	-0.7	-0.8	0.2	-1.0	0.3
Birth weight of first child	2.6	4.7	11.4	0.8	1.5	2.3	2.1	-1.1	2.8	2.0	1.5	2.6	2.4	3.4
Peak expiratory flow (PEF)	2.4	5.6	12.7	-0.1	1.1	2.4	2.9	-2.3	1.4	2.8	2.4	1.2	3.6	3.3
Pulse wave reflection index	1.2	1.5	4.6	0.9	1.7	0.9	1.4	-0.6	0.6	2.1	1.1	0.5	1.5	1.3
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.6	-1.1	-1.4	-0.9	-1.0	0.5	-1.6	-1.0	-0.4	-1.9	-1.1	-1.6
Loud music exposure frequency	0.5	0.6	1.3	0.1	0.2	0.9	1.2	-0.8	0.1	1.1	1.1	-0.1	0.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	0.8	1.0	0.1	0.1	0.3	1.0	0.9	-0.5	1.2	0.5	1.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.1	1.3	0.7	-0.4	-2.1	2.3	1.1	-1.5	-1.7	1.2	-2.0	0.2
Blood clot in the leg (DVT)	1.8	2.3	5.0	-0.1	-0.5	-2.0	-1.8	1.0	-1.1	-2.2	-1.2	-1.6	-2.0	-1.8
Medication: Paracetamol	1.2	2.1	6.2	-0.7	-1.3	-1.9	-0.7	0.2	-1.7	-1.4	-1.4	-1.3	-1.2	-2.5
Headache pain in last month	0.5	0.9	1.9	0.4	-0.7	-1.1	-1.0	1.2	-0.3	-1.0	-1.4	-0.4	-1.2	-1.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.6	2.1	2.4	0.3	-0.6	0.4	1.5	-0.5	-0.1	0.8	-0.5	1.0
Glaucoma (self-reported)	1.2	1.5	3.2	0.6	0.8	1.3	1.8	-1.3	0.7	1.4	1.6	0.5	1.5	1.0
Gout (self-reported)	1.3	1.7	4.4	0.0	0.0	-1.1	-1.8	1.8	0.4	-1.9	-2.1	1.2	-1.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.4	-0.4	-1.1	-0.4	-0.9	0.8	0.0	-1.1	-0.8	0.7	-1.2	-0.6
Medication: Amlodipine	0.3	0.5	1.4	0.2	0.2	1.2	0.2	0.4	0.7	0.4	0.9	0.6	0.9	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.3	-0.0	-0.7	-0.2	-1.1	-0.6	-0.8	-0.4	-0.5	-0.9	-1.3
Birth weight	1.0	2.2	6.1	0.1	-0.0	0.9	2.2	-2.2	0.1	1.9	1.7	0.1	2.5	1.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	0.8	1.1	-0.6	-0.1	0.2	-0.2	-0.2	0.2	-1.2	-0.5	-1.1
High blood pressure (siblings)	2.7	3.9	10.4	-0.5	-1.0	-2.0	-3.2	2.3	-0.5	-2.2	-2.5	0.2	-3.0	-1.3
Forced vital capacity (FVC), Best measure	1.0	3.7	10.4	-1.5	-0.2	1.8	2.3	-2.6	-0.3	1.8	2.6	-0.4	3.2	1.7
Body fat percentage	1.1	4.2	11.2	-1.5	-2.3	-2.3	-1.3	0.7	-2.5	-1.7	-1.8	-1.8	-1.8	-3.3
Leg fat percentage (right)	0.9	3.4	8.5	-0.3	-1.1	-2.3	-1.8	1.5	-1.9	-1.5	-2.0	-1.4	-2.2	-2.9
Arm fat-free mass (right)	0.7	3.8	8.3	-2.8	-2.6	-1.4	-1.0	-1.4	-2.9	-2.0	-0.8	-1.9	-1.0	-2.1
Exposure to tobacco smoke outside home	2.6	3.4	8.2	1.5	2.4	1.5	1.1	0.4	2.9	1.5	0.9	2.5	1.2	2.7
Comparative body size at age 10	0.3	0.8	2.6	-0.8	-1.6	-0.7	-0.5	0.5	-0.7	-0.7	-1.0	-0.1	-0.9	-1.4
Number of full brothers	0.4	0.5	3.2	0.3	-0.2	0.9	0.0	0.2	1.2	0.1	-0.4	1.8	-0.1	0.6
Worry too long after embarrassment	0.7	1.2	2.7	-1.6	-1.6	-0.1	0.2	-1.1	-1.6	-0.2	0.5	-1.6	-0.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.3	5.6	13.4	-2.0	-3.2	-2.0	-0.6	-0.2	-3.5	-1.4	-0.5	-3.7	-1.5	-3.7
Wheeze or whistling in the chest in last year	2.3	4.0	12.4	-0.3	-1.2	-2.5	-1.5	1.8	-1.9	-1.9	-1.8	-2.1	-1.9	-3.5
Number of children fathered	0.5	0.6	1.8	-1.3	-1.0	-0.1	0.2	-0.4	-1.0	-0.1	0.5	-1.2	0.5	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	0.7	0.4	-0.6	-0.2	0.4	0.5	-0.0	-0.9	0.8	-0.4	0.6
Age at first live birth	1.1	2.0	5.1	-2.1	-1.3	1.1	1.5	-2.3	-1.1	0.9	1.4	-0.7	1.5	0.9
Pulse wave peak to peak time	1.1	1.3	3.5	-0.8	0.1	1.9	0.5	-1.5	1.1	-0.4	1.7	0.7	0.5	1.7
Health satisfaction	1.3	1.6	4.9	-0.5	-0.2	-1.8	-1.1	0.2	-1.1	-1.1	-1.4	-0.9	-1.7	-2.2
Shortness of breath walking on level ground	6.0	7.2	17.0	-1.6	-1.6	-2.8	-2.3	1.3	-2.6	-3.4	-2.1	-2.9	-3.2	-4.1
Qualifications: College or University degree	1.5	4.8	13.4	-3.7	-3.0	1.9	2.1	-2.5	-1.4	0.9	2.3	-1.7	2.1	0.6
Eye problems/disorders: None of the above	0.9	1.0	1.9	1.3	1.2	0.6	-0.6	1.2	1.4	0.7	-0.1	1.4	-0.6	1.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	4.2	-2.0	-1.8	0.4	-0.3	-0.2	-1.1	-0.7	0.4	-1.1	-0.1	-0.6
Emphysema/chronic bronchitis	1.0	1.1	2.7	-0.9	-0.5	1.0	1.2	-0.7	-0.7	1.0	1.6	-1.2	1.5	-0.1
Medication for pain relief, constipation, heartburn	1.1	2.0	4.5	1.2	1.7	1.6	0.8	-0.8	1.8	1.0	1.5	1.3	1.1	2.1
Neck or shoulder pain in last month	0.5	0.7	2.1	1.4	0.8	-0.4	-0.4	1.3	-0.3	0.2	-0.3	-1.1	-0.9	-0.7
Medication: Blood pressure	0.5	0.9	3.6	-1.9	-1.6	-0.3	0.3	-0.2	-1.3	0.1	0.2	-1.1	0.3	-0.6
Angina (self-reported)	0.1	0.2	0.6	-0.8	-0.2	-0.1	-0.2	0.4	-0.4	-0.7	-0.4	-0.4	-0.3	-0.2
Migraine (self-reported)	0.9	1.1	2.7	0.6	1.0	1.4	0.8	-0.4	1.0	1.1	1.2	0.6	1.2	1.6
Medication: Ibuprofen	2.5	3.0	5.6	-0.8	-1.4	-2.4	-1.7	1.0	-2.0	-1.6	-2.3	-1.5	-1.4	-2.1
Medication: Allopurinol	0.9	1.2	3.4	-0.2	-0.2	-1.1	-1.3	1.3	0.4	-1.3	-1.9	1.2	-0.9	-0.7
Medication: Omeprazole	0.1	0.1	0.4	0.6	0.2	-0.3	-0.4	0.4	-0.3	-0.3	-0.3	-0.1	0.3	-0.1
Medication: Seretide 50 evohaler	0.4	0.5	2.9	0.5	-0.2	-0.5	-0.8	1.7	-0.3	0.0	-0.7	-0.4	-0.4	-0.4
Mean time to correctly identify matches	0.0	0.1	0.3	0.1	0.1	0.2	0.1	0.4	0.5	-0.2	0.1	0.3	0.3	0.5
Heart disease (mother)	0.7	0.8	2.1	0.9	1.3	0.5	-0.5	1.1	1.2	0.0	-0.2	0.8	-0.5	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.5	0.5	-0.1	0.8	1.6	-1.1	-0.1	0.8	1.1	-0.4	1.3	0.1
Whole body fat mass	1.4	5.8	12.9	-2.4	-3.0	-2.4	-1.6	0.4	-3.2	-2.1	-1.9	-2.3	-2.0	-3.6
Leg fat mass (right)	1.3	5.2	12.6	-1.6	-2.4	-2.6	-1.7	0.7	-2.9	-1.9	-2.1	-2.1	-2.2	-3.5
Arm predicted mass (right)	0.9	4.4	8.7	-2.6	-2.6	-1.9	-1.5	-1.0	-2.9	-2.4	-1.3	-2.0	-1.6	-2.4
Pulse rate, automated reading	0.1	0.3	1.1	-0.7	-1.0	0.1	0.4	-0.3	-0.0	0.3	-0.3	0.6	-0.1	-0.8
Alcohol intake frequency.	0.1	0.3	1.3	1.2	0.5	-0.2	0.4	-0.6	-0.0	0.7	0.2	0.2	0.1	-0.2
Comparative height size at age 10	1.2	6.5	14.0	-3.7	-3.5	-1.0	0.3	-3.1	-3.7	-1.4	0.7	-3.3	-0.1	-2.8
Number of full sisters	0.5	0.6	1.2	0.7	0.6	-0.2	-0.9	0.8	0.9	0.3	-0.9	1.1	-0.6	1.0
Suffer from ‘nerves’	0.2	0.3	1.0	-1.0	-0.6	0.1	0.0	-0.6	-0.2	-0.9	0.4	-0.6	-0.4	-0.3
Overall health rating	2.6	5.7	14.2	-0.4	-1.1	-2.6	-2.8	1.8	-1.7	-2.6	-2.9	-1.3	-3.8	-3.0
Chest pain or discomfort	2.0	3.0	5.2	-1.9	-1.4	-1.3	-2.1	1.4	-1.6	-2.3	-1.3	-1.5	-2.0	-1.9
Had major operations	3.2	3.7	8.2	-2.2	-2.7	-2.0	-0.3	-0.7	-2.8	-1.7	-0.8	-2.9	-0.4	-2.1
Age at last live birth	0.5	0.7	2.1	-1.5	-1.0	0.1	0.3	-1.4	-1.2	0.2	0.3	-0.7	0.1	0.0
Family relationship satisfaction	1.4	1.7	3.6	-1.5	-1.6	-1.3	0.2	-1.3	-1.7	-0.5	-0.2	-1.9	-0.7	-1.7
Leg pain on walking	2.7	3.4	7.7	0.1	-0.8	-2.1	-2.1	1.4	-1.0	-2.5	-2.2	-0.7	-2.8	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	1.0	0.2	-1.0	-0.9	1.6	0.5	0.2	-1.3	1.2	-0.7	-0.5
Commuting to job workplace: Car/motor vehicle	2.7	3.1	7.1	2.7	2.6	1.5	1.1	-0.7	2.3	1.6	1.3	1.9	0.6	1.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.9	-0.2	-0.7	-1.4	-1.7	1.1	-1.1	-1.0	-1.6	-0.2	-0.8	-1.1
Medication: Aspirin	0.4	0.6	2.3	-1.5	-1.1	0.4	0.7	-0.7	-0.7	0.3	0.5	-0.6	0.2	-0.3
Supplements: Vitamin C	0.6	0.7	1.4	1.1	0.4	-0.7	-0.8	0.8	0.8	-0.6	-1.0	0.8	-1.2	0.5
Knee pain experienced in last month	0.2	0.3	0.8	0.0	-0.5	-0.8	-0.1	0.7	-0.5	-0.3	-0.9	-0.1	-0.6	-0.8
Hypertension (Self-reported)	0.6	1.6	4.3	-0.0	-0.5	-1.4	-1.8	2.1	-0.1	-1.4	-1.9	0.3	-1.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.2	0.8	1.0	0.9	0.1	1.5	0.6	0.9	0.3	0.4	1.0	1.1
Illnesses of father: Heart disease	0.4	0.5	2.1	-1.4	-0.7	0.3	0.5	-1.2	-0.4	-0.3	0.7	-0.6	0.2	-0.4
Illnesses of siblings: Diabetes	4.5	5.5	13.0	-0.7	-1.4	-3.6	-1.9	0.6	-2.7	-2.4	-2.6	-2.4	-2.1	-3.4
Smoking status: Previous	0.4	0.6	1.5	-1.0	-0.6	-0.7	-0.8	0.9	-0.2	-1.2	-1.2	-0.3	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.3	-2.1	-2.1	-0.5	0.5	-1.9	-2.0	-1.1	0.3	-1.9	-0.2	-1.4
Whole body fat-free mass	1.2	6.6	13.3	-3.5	-3.6	-2.1	-1.4	-1.1	-3.6	-2.6	-1.4	-2.6	-1.6	-3.0
Leg fat-free mass (right)	1.4	7.5	17.6	-4.1	-4.2	-1.8	-0.7	-1.8	-4.0	-2.2	-0.7	-3.0	-1.0	-3.1
Arm fat percentage (left)	1.1	4.4	12.1	-1.5	-2.5	-2.2	-1.3	0.9	-2.4	-1.8	-1.9	-1.9	-2.0	-3.5
Average weekly red wine intake	1.0	1.5	3.3	-0.8	-0.3	1.4	1.8	-1.3	0.7	1.2	1.5	0.6	1.6	1.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.9	0.7	0.9	0.2	0.3	1.0	-0.4	0.4	0.3	0.2	1.0
Mood swings	0.7	1.3	2.8	-0.5	-1.0	-1.2	-0.7	-0.1	-1.7	-1.3	-0.6	-1.7	-1.2	-1.3
Loneliness, isolation	1.0	1.3	3.2	-0.2	-0.6	-0.9	-1.5	1.2	-0.8	-1.8	-0.9	-1.1	-1.5	-1.3
Long-standing illness, disability or infirmity	2.5	3.8	7.4	-1.4	-2.1	-1.6	-1.5	0.1	-2.3	-2.1	-0.8	-2.7	-2.5	-2.6
Ever had bowel cancer screening	0.7	0.8	2.7	0.2	0.0	-0.7	-1.0	1.4	0.1	-1.7	-1.1	-0.0	-0.8	-0.8
Diabetes diagnosed by doctor	3.4	5.5	11.2	-1.6	-2.0	-3.3	-1.6	-0.0	-3.1	-1.9	-2.2	-2.8	-2.0	-3.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.9	0.1	-0.3	0.2	-0.1	-0.6	0.9	-0.3	-0.2	1.4	-0.9	-0.2
Friendships satisfaction	0.6	0.7	2.9	-1.2	-0.5	0.1	0.6	-1.7	-0.9	0.5	0.8	-0.7	0.6	-0.0
Qualifications: nursing, teaching	0.7	1.1	2.3	-0.8	-0.3	1.3	1.1	-1.1	-0.2	1.5	1.5	-0.5	1.1	0.9
Commuting to job workplace: Walk	0.4	0.4	1.7	-0.5	-0.9	-0.4	-0.1	0.1	-1.1	-0.2	0.0	-1.3	0.2	-0.5
Eye problems/disorders: Cataract	0.5	0.6	2.1	-0.7	-1.5	-0.7	0.2	-0.6	-0.9	-0.8	-0.5	-0.3	0.5	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	7.3	1.8	2.7	0.0	-0.0	0.7	1.2	0.3	0.2	-0.0	0.6	1.6
Medication for cholesterol	0.8	1.2	5.9	-1.2	-0.4	0.1	1.6	-2.4	-0.4	0.9	0.7	0.4	1.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.0	-0.6	-0.4	-0.8	-0.5	-0.1	-0.6	-1.4	-0.8	-0.3	-0.6	-0.7
Back pain experienced in last month	2.4	3.5	9.0	-1.5	-2.2	-1.9	-1.1	0.4	-2.5	-1.3	-1.2	-2.3	-1.7	-3.0
Mineral and other dietary supplements	0.7	1.0	2.7	0.3	0.2	1.5	1.2	-1.1	0.2	0.6	1.6	-0.1	1.4	1.0
Breast cancer (self-reported)	0.6	0.8	3.3	0.4	0.7	0.2	0.1	-0.1	1.4	-0.5	-0.4	1.8	0.2	1.5
Asthma (self-reported)	1.7	3.4	8.1	0.2	-0.6	-2.0	-2.1	1.4	-1.2	-2.1	-1.9	-1.3	-2.8	-2.7
Osteoporosis (self-reported)	0.4	0.5	2.3	-1.5	-1.2	-0.0	-0.3	-0.1	-0.7	-0.7	-0.4	-0.2	-0.1	-0.5
Osteoarthritis (self-reported)	1.6	2.1	4.1	1.7	1.2	1.8	0.6	1.0	2.0	1.6	0.7	1.9	0.6	1.6
Medication: Aspirin	0.4	0.6	2.5	-1.6	-1.3	0.6	0.6	-0.6	-0.6	0.3	0.6	-0.3	0.4	-0.1
Medication: Gliclazide	0.7	0.7	1.7	-0.0	-0.2	-1.2	-0.8	0.3	-0.7	-0.8	-1.1	-0.6	-1.1	-1.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	0.5	0.4	0.7	0.1	0.2	0.9	0.3	0.3	1.0	0.4	1.2
Smoking status: Current	2.1	3.4	7.3	-2.1	-2.3	-2.0	-1.1	-0.0	-2.4	-1.4	-1.1	-2.2	-1.2	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	9.2	-0.0	0.7	2.2	2.1	-1.3	1.6	2.3	1.8	2.0	2.8	3.0
Whole body water mass	1.1	6.5	13.0	-3.4	-3.5	-2.1	-1.4	-1.1	-3.6	-2.6	-1.4	-2.6	-1.6	-3.0
Leg predicted mass (right)	1.4	7.6	17.5	-4.1	-4.2	-1.9	-0.8	-1.6	-4.0	-2.3	-0.9	-3.0	-1.1	-3.2
Arm fat mass (left)	1.3	5.3	12.5	-2.2	-3.0	-2.1	-1.4	0.3	-3.0	-2.1	-1.7	-2.2	-1.9	-3.5
Number of self-reported non-cancer illnesses	0.6	1.1	2.6	-0.2	-1.2	-0.9	-1.0	1.3	-0.3	-1.5	-1.2	-0.3	-1.6	-1.1
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.4	-0.7	0.2	0.6	-0.5	-0.6	0.1	0.5	-0.8	0.6	-0.2
Miserableness	1.9	3.3	6.2	-0.3	-1.8	-2.2	-1.4	0.5	-2.4	-1.7	-1.4	-2.5	-1.9	-2.5
Guilty feelings	0.8	1.2	2.7	-1.0	-1.0	-0.9	-1.1	0.4	-1.0	-1.6	-1.0	-1.0	-1.5	-1.3
Wears glasses or contact lenses	0.2	0.3	0.8	-0.3	-0.3	-0.1	-0.8	0.9	-0.5	-0.6	-0.4	-0.4	-0.3	0.7
Ever taken oral contraceptive pill	1.6	1.8	4.5	-1.3	-2.1	-0.9	1.4	-0.9	-1.7	0.8	0.2	-1.3	0.6	-2.0
Hearing aid user	2.6	2.9	5.4	1.1	-0.0	-1.9	-2.3	2.2	-1.0	-1.9	-1.7	-1.3	-2.1	-1.9
Mother’s age at death	0.7	0.9	2.6	-1.6	-1.4	0.2	1.0	-1.3	-0.6	-0.3	0.6	-0.5	1.0	-0.3
Financial situation satisfaction	2.7	3.3	9.5	0.3	0.4	-2.1	-2.3	0.6	-0.8	-2.8	-1.9	-1.2	-3.1	-1.7
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.3	-1.0	-1.6	-0.6	0.1	-1.5	-2.0	-1.1	0.5	-2.3	-1.0	-1.9
Commuting to job workplace: Public transport	0.9	1.0	2.6	-1.6	-1.5	-0.1	0.7	-1.4	-1.1	-0.7	0.5	-1.3	0.2	-0.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.7	0.4	0.6	0.4	-0.1	0.6	0.8	0.4	0.5	0.1	0.5
Medication: Blood pressure	0.3	0.6	1.6	1.0	1.1	0.2	-1.0	1.3	0.8	-0.3	-0.3	0.4	-0.6	0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.5	-0.5	-1.5	-0.3	-0.9	1.6	-1.0	-0.3	-0.4	-0.9	-0.6	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.9	0.6	0.9	-2.0	-1.4	1.2	0.0	-0.7	-1.8	-0.1	-1.5	-0.4
High cholesterol (Self-reported)	0.2	0.4	1.1	0.0	-0.6	1.0	0.1	0.8	1.0	-0.1	0.0	1.0	-0.2	0.4
Medication: Bendroflumethiazide	0.2	0.4	0.9	0.2	0.7	0.1	1.0	-0.9	-0.0	0.8	0.6	-0.2	0.7	-0.0
Medication: Paracetamol	1.7	2.7	7.6	-1.1	-1.6	-2.0	-1.1	0.6	-1.7	-1.8	-1.6	-1.3	-1.6	-2.8
Medication: Lisinopril	0.5	0.6	1.7	-0.1	-0.9	-0.8	-0.3	0.0	-1.2	-0.4	-0.3	-1.2	-0.5	-1.3
Medication: Atorvastatin	0.6	0.7	1.2	-0.8	-0.8	-0.9	-1.1	0.7	-0.6	-1.1	-1.1	-0.4	-0.9	-0.4
Illnesses of father: High blood pressure	0.5	0.6	1.9	-1.4	-0.8	-0.4	-0.0	-0.3	-0.9	-1.2	-0.0	-1.4	-0.0	-0.3
Alcohol drinker status: Never	0.9	1.1	2.9	0.9	0.8	1.4	-0.4	0.3	1.5	0.2	0.5	1.7	0.0	1.7
Ever smoked	0.6	1.0	3.5	-1.9	-1.6	-0.5	-0.3	0.8	-0.8	-1.0	-0.6	-1.3	0.2	-0.1
Basal metabolic rate	1.3	7.4	14.6	-3.6	-3.8	-2.3	-1.5	-1.0	-3.8	-2.7	-1.4	-2.8	-1.7	-3.3
Leg fat percentage (left)	0.6	2.3	6.0	-0.2	-0.9	-2.0	-1.4	1.2	-1.6	-1.1	-1.7	-1.1	-1.8	-2.4
Arm fat-free mass (left)	0.9	4.6	9.1	-2.8	-2.9	-1.9	-1.4	-0.8	-3.0	-2.3	-1.3	-2.0	-1.4	-2.4
Number of operations (self-reported)	0.3	0.4	1.1	0.5	-0.7	-1.0	0.2	0.7	-0.3	-0.6	-0.7	-0.4	0.1	-0.9
Average weekly beer plus cider intake	1.6	2.3	7.1	-1.2	-1.6	-1.5	-0.3	0.1	-2.3	-1.6	-0.4	-2.7	-0.0	-2.0
Irritability	1.5	2.5	4.4	-1.5	-2.1	-1.4	-1.2	0.5	-2.0	-1.7	-0.8	-2.0	-1.6	-1.7
Risk taking	0.3	0.4	1.0	-0.1	-0.7	-0.8	-0.7	0.6	-0.3	-0.4	-1.0	0.1	-0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.2	-1.0	-1.4	-1.1	-0.0	-0.6	-1.3	-0.8	-0.7	-0.6	-0.4	-1.5
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.4	0.2	-0.7	-0.6	0.3	0.1	-0.2	-0.8	0.4	-0.9	-0.8
Age started oral contraceptive pill	0.6	0.7	2.6	1.4	1.6	-0.2	-0.5	0.0	1.1	-0.5	-0.4	0.8	-0.9	0.4
Diastolic blood pressure, automated reading	0.5	1.7	3.7	-0.6	-1.1	-1.2	-1.8	1.2	-0.4	-1.6	-1.9	0.4	-1.7	-1.1
Ever depressed for a whole week	1.9	2.4	4.4	-1.4	-1.8	-1.3	-1.1	-0.0	-1.9	-1.9	-0.7	-2.1	-1.5	-1.9
Unable to work because of sickness or disability	1.2	1.5	2.9	-1.3	-1.2	-1.3	-1.1	0.3	-1.3	-1.6	-0.9	-1.7	-1.0	-1.2
Commuting to job workplace: Cycle	0.6	0.7	2.2	-1.0	-1.5	-0.5	-1.1	0.3	-0.7	-0.5	-1.1	0.3	-0.9	-0.4
Myopia	1.1	1.5	3.0	0.9	1.4	1.4	1.2	-0.8	1.6	1.2	1.2	1.1	0.8	1.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	0.2	0.5	1.0	1.4	-1.5	0.3	1.2	1.3	0.1	1.1	0.7
Cholesterol lowering medication	0.6	1.0	2.6	1.1	1.2	0.8	-0.8	1.6	1.3	-0.3	-0.0	0.6	-0.8	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.2	-0.2	-0.7	-0.8	0.4	-0.5	-0.7	-0.8	-0.1	-0.3	-0.6
Pain experienced in last month	1.2	2.0	4.3	-0.2	0.3	1.5	1.6	-2.0	0.9	0.9	1.7	1.0	2.1	1.6
Supplements: Calcium	0.8	0.8	1.8	-1.3	-1.3	-1.1	-0.5	-0.1	-0.7	-0.8	-1.2	-0.1	-0.8	-1.0
Basal cell carcinoma (self-reported)	1.2	1.4	3.9	1.1	1.7	0.8	-0.7	1.0	2.0	-0.3	-0.2	1.7	-0.3	1.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.7	-1.6	-1.6	0.3	1.4	-0.8	-1.4	0.7	0.7	-1.1	1.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.9	-0.1	-0.5	-1.9	-1.5	0.7	-1.1	-2.0	-1.1	-1.5	-1.6	-1.7
Heart disease (siblings)	0.6	0.7	1.6	0.7	0.2	-0.5	-0.9	1.1	0.5	-0.9	-0.9	0.8	-1.3	-0.9
Alcohol drinker status: Previous	2.2	2.5	6.9	-0.0	-0.7	-2.6	-1.4	0.7	-1.9	-1.0	-1.8	-1.8	-1.1	-2.4
Pack years of smoking	0.6	0.9	2.6	0.2	-0.6	-0.6	-1.0	1.4	-0.7	-0.9	-0.6	-0.8	-1.0	-1.6
Impedance of whole body	0.1	0.6	1.4	-0.4	-0.0	0.9	1.1	-0.6	0.4	1.0	1.2	-0.1	0.9	0.4
Leg fat mass (left)	1.1	4.4	10.4	-1.5	-2.3	-2.4	-1.6	0.6	-2.7	-1.8	-2.0	-1.8	-2.0	-3.2
Arm predicted mass (left)	0.9	4.4	8.2	-2.5	-2.7	-1.8	-1.6	-0.8	-2.9	-2.4	-1.3	-1.8	-1.7	-2.4