Hub : Genes

BHMT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3270 0.0500 0.0e+00 0.335 0.299 0.369 0.386 0.377 4.6e-42 7.3e-37 3.2e-47 7.6e-50 2.5e-48
2 ROSMAP Brain Pre-frontal Cortex 0.1707 0.0398 0.0e+00 0.182 0.180 0.203 0.208 0.197 8.4e-23 1.4e-22 1.6e-25 3.1e-26 9.7e-25
3 TCGA Breast Invasive Carcinoma 0.0459 0.0235 7.7e-07 0.022 0.041 0.038 NA 0.035 2.0e-05 8.2e-09 2.1e-08 NA 9.2e-08
4 TCGA Head and Neck Squamous Cell Carcinoma 0.2774 0.0757 2.0e-15 0.149 0.156 0.160 NA 0.159 1.8e-16 3.6e-17 1.2e-17 NA 1.9e-17
5 TCGA Kidney Renal Clear Cell Carcinoma 0.1780 0.0579 2.9e-10 0.044 0.090 0.073 NA 0.085 9.5e-06 2.6e-10 1.3e-08 NA 8.9e-10
6 TCGA Brain Lower Grade Glioma 0.0407 0.0212 9.5e-05 0.036 0.016 0.019 NA -0.001 5.4e-05 5.9e-03 2.4e-03 NA 5.4e-01
7 TCGA Lung Squamous Cell Carcinoma 0.2505 0.0923 4.2e-10 0.111 0.101 0.106 NA 0.102 1.6e-12 1.8e-11 4.7e-12 NA 1.1e-11
8 TCGA Ovarian Serous Cystadenocarcinoma 0.1240 0.0550 5.1e-05 0.076 0.088 0.093 NA 0.077 7.3e-06 1.5e-06 7.8e-07 NA 6.8e-06
9 TCGA Prostate Adenocarcinoma 0.0404 0.0264 2.5e-03 0.030 0.000 0.008 NA 0.015 3.5e-04 3.0e-01 4.6e-02 NA 8.6e-03
10 TCGA Testicular Germ Cell Tumors 0.2680 0.1060 9.6e-05 0.218 0.154 0.173 NA 0.211 3.1e-08 4.2e-06 1.1e-06 NA 5.5e-08
11 TCGA Thyroid Carcinoma 0.0470 0.0250 6.6e-05 0.029 0.039 0.032 NA 0.032 7.0e-04 9.8e-05 4.4e-04 NA 4.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.7 1.1 3.1 0.1 -0.5 -1.4 -1.1 1.8 -1.0 -0.6 -1.3 -0.7 -0.4 -1.2
Bipolar Disorder or Schizophrenia 0.6 1.4 4.1 2.0 1.7 0.5 -0.9 1.7 1.4 -0.3 -0.2 0.9 -0.9 1.0
Depressed Affect (Nagel 2018) 1.8 3.8 6.6 -0.4 -1.5 -2.0 -2.2 1.1 -2.1 -2.6 -1.2 -2.5 -2.5 -2.1
Depression (Nagel 2018) 1.4 2.1 5.9 -0.2 -1.6 -1.5 -1.2 0.5 -1.2 -1.5 -1.2 -1.0 -2.3 -2.4
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.9 1.2 0.5 0.4 -0.4 1.4 0.7 0.6 0.1 0.1 0.1 0.8
Neuroticism (Nagel 2018) 0.6 1.4 3.9 -0.3 -0.7 -0.9 -1.5 0.5 -1.1 -2.0 -0.5 -1.5 -1.9 -1.0
Schizophrenia (2018) 1.5 3.0 7.0 2.6 2.6 1.8 -0.3 0.8 2.6 0.1 0.8 1.7 -0.9 2.2
Schizophrenia vs Biploar Disorder 2.3 3.0 6.7 2.2 2.6 1.4 1.3 -0.4 2.0 1.8 1.1 1.7 1.1 2.3
Worry (Nagel 2018) 0.2 0.5 1.3 0.6 1.0 1.1 -0.2 0.2 0.9 -0.4 0.8 0.2 -0.2 1.2
Alzheimer’s Disease (in mother) 0.4 0.5 1.3 -0.8 -0.2 -0.9 -0.2 -0.3 -1.0 -0.2 -0.6 -0.8 -0.4 -1.1
Alzheimer’s Disease (in father) 0.9 0.9 2.1 1.1 1.1 -1.1 -1.2 1.4 0.2 -0.3 -1.0 0.0 -1.4 -0.6
Alzheimer’s Disease (including proxy) 0.8 1.2 3.2 -0.2 0.1 -1.6 -0.9 0.1 -1.1 -1.0 -1.2 -0.9 -1.5 -1.8
Crohns Disease (2017) 0.2 0.4 1.8 0.4 0.3 -0.6 -1.0 0.5 0.1 -0.5 -0.6 0.0 -1.4 -0.7
Irritable Bowel Disease (IBD) 0.4 1.1 2.2 -0.6 -0.7 -1.2 -1.5 1.2 -0.4 -1.0 -1.4 0.2 -1.2 -1.1
Ulcerative Colitis (UC) 0.6 1.1 2.3 -1.1 -1.2 -1.4 -1.1 1.2 -0.7 -0.8 -1.5 0.1 -0.5 -1.2
Major Depression (MDD) 3.2 3.9 9.6 -0.1 -0.9 -2.4 -1.7 -0.3 -2.6 -1.5 -1.5 -2.7 -2.4 -3.1
Reaction Time 0.2 0.4 1.4 0.3 0.3 0.8 0.3 0.2 1.0 0.0 0.6 0.7 0.4 1.2
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.7 -0.5 -0.4 0.7 -0.2 0.7 0.8 0.3 0.2 1.0 0.6 1.3
Breast Cancer 0.8 2.0 4.0 -0.2 -1.2 -1.8 -1.6 0.9 -0.7 -2.0 -2.0 -0.0 -1.8 -1.6
Ovarian Cancer 1.2 1.6 3.1 0.3 0.3 1.4 1.8 -1.5 1.5 1.1 1.3 1.5 1.4 0.9
Prostate Cancer 0.2 0.3 0.7 0.8 0.7 -0.4 0.4 -0.3 -0.2 0.9 0.1 -0.6 0.1 -0.3
Age at First Birth 0.5 0.8 1.9 0.6 0.8 0.8 0.7 -0.0 0.4 1.3 1.1 -0.2 1.4 1.1
Bipolar Disorder (2011) 0.5 0.5 1.7 0.4 -0.1 -1.3 -0.1 1.0 -0.8 0.2 -0.8 -0.7 0.4 -0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.1 -1.0 -0.8 0.6 0.7 -0.5 0.1 0.1 0.5 0.3 0.8 0.3
Coronary Artery Disease (CAD) 0.7 0.9 4.4 0.5 0.6 0.8 -0.3 0.4 1.4 0.9 -0.1 2.1 -0.0 1.1
Crohns Disease (2012) 0.2 0.4 1.4 0.4 0.6 0.1 -1.1 1.2 0.5 -0.4 -0.1 0.3 -0.7 -0.0
Mean Putamen Volume 1.9 2.2 3.9 -0.7 -1.5 -1.9 -1.1 0.8 -1.7 -1.5 -1.7 -1.4 -1.2 -2.0
Fasting Glucose 2.2 2.7 7.9 -0.7 -1.2 -2.8 -1.2 0.5 -2.2 -1.4 -1.7 -1.5 -1.2 -2.1
HbA1C 0.3 0.3 0.7 0.4 0.5 0.8 0.4 0.5 0.8 0.1 0.5 -0.4 0.4 0.9
HDL Cholesterol 3.3 5.5 9.4 1.7 2.8 2.5 1.9 -0.5 2.7 3.0 2.1 2.3 2.1 3.1
LDL Cholesterol 2.3 3.6 7.3 2.7 2.4 1.6 1.2 0.9 2.3 1.9 1.1 2.0 1.8 2.1
Lupus 1.2 1.9 8.3 2.9 1.9 -0.6 -0.5 1.5 1.5 -0.1 -1.1 1.2 -0.8 0.4
Neuroticism (2016) 1.7 2.4 5.2 0.4 -1.4 -1.9 -1.2 1.6 -1.4 -1.2 -1.7 -1.4 -1.8 -2.3
Primary Biliary Cirrhosis 3.2 4.6 12.8 1.7 0.0 -2.2 -2.8 3.6 0.1 -1.5 -3.3 1.0 -2.4 -1.6
Rheumatoid Arthritis 0.4 0.5 1.8 0.6 1.3 -0.2 -0.7 0.7 -0.4 0.1 0.1 -1.4 -0.6 0.3
Schizophrenia (2014) 1.5 3.4 11.2 3.4 3.1 1.2 -0.2 1.2 2.5 -0.1 0.2 1.9 -0.7 1.7
Triglycerides 0.2 0.3 1.2 0.6 -0.3 -0.8 -0.3 -0.0 -0.4 -0.5 -0.4 -0.1 -0.6 -1.1
Type 2 Diabetes (T2D) (2012) 3.2 3.7 7.8 -0.9 -1.5 -2.3 -2.1 0.9 -2.0 -1.7 -1.6 -2.2 -2.5 -2.8
Ulcerative Colitis 0.6 0.9 2.7 -0.5 -0.8 -0.9 -1.0 1.5 -0.6 -0.6 -1.0 -0.1 -0.5 -1.6
Blood Eosinophil Count 0.1 0.9 2.3 -0.3 0.5 1.4 1.4 -0.2 0.3 1.5 1.1 0.4 1.5 0.4
Blood Platelet Count 0.6 6.6 15.2 2.7 2.6 3.1 1.5 0.1 3.5 2.3 2.1 2.4 2.0 3.9
Blood Red Count 0.0 0.5 1.3 -1.1 -1.0 -0.1 -0.7 0.3 -0.9 -0.4 -0.5 -0.2 -0.5 -0.8
Blood White Count 1.2 8.6 20.7 -3.4 -4.5 -2.9 -0.6 -1.2 -4.4 -1.0 -1.3 -3.2 -0.9 -4.5
Heel T-Score 0.8 6.0 16.1 -0.2 -2.9 -3.2 -1.6 0.3 -3.1 -1.5 -2.2 -2.4 -2.4 -4.0
BMI 0.5 2.8 8.4 -1.8 -2.9 -1.2 -0.3 0.2 -2.4 -1.0 -0.9 -1.5 -0.7 -2.6
Height 1.0 19.7 42.8 -6.5 -5.7 -3.8 -3.0 -1.3 -6.0 -4.7 -2.3 -4.7 -2.8 -4.8
Waist Hip Ratio (WHR) 0.0 0.2 0.6 0.1 0.3 -0.0 -0.2 0.5 0.3 0.8 -0.4 0.6 -0.0 -0.1
Systolic Blood Pressure 0.4 1.8 5.6 0.1 -0.4 -1.7 -1.8 1.5 -0.1 -1.5 -2.4 0.3 -1.7 -0.8
Smoking Status 1.7 4.1 8.8 -3.0 -2.8 -2.0 -1.3 0.0 -2.5 -1.8 -1.6 -1.9 -1.2 -2.4
Allergy or Eczema 0.3 0.8 2.3 -0.3 -1.0 -0.7 -0.0 -0.9 -1.2 -1.0 0.0 -1.3 -0.4 -1.5
Cardiovascular Disease 0.7 2.2 5.0 -0.6 -1.3 -1.5 -1.9 2.2 -0.3 -1.2 -2.2 0.5 -1.8 -1.3
Hypothyroidism (self reported) 0.1 0.1 0.3 0.3 -0.5 -0.1 -0.3 0.3 -0.0 -0.3 -0.2 0.4 -0.6 -0.4
Respiratory disease 2.8 6.3 15.1 -0.2 -1.7 -2.7 -2.5 2.1 -2.4 -2.5 -2.4 -2.6 -3.1 -3.9
Type 2 Diabetes (T2D) (2018) 5.4 10.2 22.4 -2.8 -3.3 -4.0 -1.9 0.2 -4.5 -1.9 -2.4 -4.1 -2.2 -4.7
Lung FEV1/FVC ratio 0.1 0.4 1.6 -0.4 -0.8 0.0 0.5 0.1 -0.4 1.3 -0.3 0.3 1.1 0.8
Lung FVC 2.1 10.9 27.6 1.9 3.2 3.8 2.7 -0.9 3.4 3.2 2.9 2.9 4.1 5.3
Neuroticism 0.6 1.6 4.4 0.7 -0.1 -1.3 -1.8 1.3 -0.9 -1.1 -1.1 -1.2 -2.1 -0.9
Chronotype (morning person) 0.1 0.2 0.7 0.3 0.6 0.8 0.2 -0.2 0.3 0.8 0.5 0.3 -0.1 0.3
Hair Pigment 0.0 0.1 0.2 -0.2 -0.3 -0.4 0.1 -0.1 -0.2 0.1 -0.1 -0.2 -0.0 -0.5
Tanning 0.2 2.6 7.2 -1.0 -1.6 -0.7 -2.3 1.3 -0.3 -2.7 -1.5 0.3 -2.5 -1.0
Hand grip strength (left) 0.7 1.9 4.8 -1.3 -0.8 1.0 1.8 -2.2 -0.6 1.2 1.5 -0.4 2.1 0.8
Number of treatments/medications taken 1.4 2.5 5.6 -1.0 -1.7 -2.2 -1.1 1.1 -1.4 -1.2 -1.9 -1.1 -1.8 -2.4
Average weekly spirits intake 2.8 3.4 8.3 -2.1 -2.4 -1.8 -0.1 -0.9 -2.9 -1.2 -0.5 -2.8 0.1 -2.4
Sensitivity / hurt feelings 0.6 1.0 3.1 0.2 -0.3 -1.4 -1.1 0.1 -0.8 -1.8 -1.1 -0.7 -1.2 -0.7
Frequency of depressed mood in last 2 weeks 1.2 1.7 4.0 -0.3 -1.2 -1.6 -1.0 0.6 -1.3 -1.3 -1.1 -1.4 -1.8 -2.0
Hearing difficulty/problems: Yes 0.2 0.3 0.8 -0.3 -0.5 -0.2 -0.4 0.8 -0.7 -0.5 -0.2 -0.9 -0.3 -0.7
Relative age of first facial hair 0.3 0.6 1.5 -0.8 -0.2 0.0 -0.9 1.2 0.6 -0.7 -1.0 1.1 -0.3 -0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.0 0.6 -0.1 -0.7 -1.0 1.2 0.2 -1.7 -1.0 -0.3 -1.7 -1.4
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.1 0.5 -0.2 -1.1 -0.3 1.3 -0.1 -0.7 -1.2 -0.5 -0.8 -1.4
Ever had hysterectomy (womb removed) 0.8 0.9 1.7 1.3 0.6 -0.9 -1.1 1.1 -0.1 -0.7 -1.1 -0.1 -1.3 -1.2
Systolic blood pressure, automated reading 1.0 2.9 7.2 0.8 -0.0 -1.7 -2.4 2.4 0.1 -2.1 -2.7 0.5 -2.1 -1.1
Eye problems/disorders: Diabetes related eye disease 3.1 3.4 6.7 -2.2 -1.9 -2.2 -0.6 -1.1 -2.6 -1.8 -1.3 -2.5 -1.0 -2.0
Angina 0.1 0.2 0.5 -0.7 -0.1 -0.0 -0.2 0.4 -0.4 -0.7 -0.3 -0.4 -0.3 -0.1
Medication for hormone replacement therapy 0.7 0.8 1.8 0.4 -0.8 -1.0 -0.5 1.0 -0.5 -0.7 -0.8 -1.1 -1.1 -1.3
Vitamin and mineral supplements 1.4 1.9 4.6 -1.0 0.0 2.1 1.4 -1.6 0.5 0.5 1.9 0.6 1.8 1.8
Supplements: Zinc 0.8 0.8 4.4 -1.3 -2.1 0.1 -0.2 0.1 -1.0 -0.4 0.2 -1.0 -0.4 -1.0
Medication: Co-codamol 0.7 0.8 2.3 -1.4 -1.5 -0.5 -0.6 0.6 -0.7 -0.6 -0.6 -0.5 -0.8 -1.0
Medication: Metformin 2.9 4.1 10.4 -0.6 -1.8 -3.0 -1.2 0.6 -2.0 -1.7 -2.5 -1.7 -2.0 -3.2
Diabetes (father) 0.4 0.5 1.1 -0.2 -0.1 -0.6 -0.6 0.2 -0.6 -0.9 -0.3 -1.1 -1.0 -1.0
Diabetes (mother) 4.2 5.3 15.1 -3.1 -3.9 -1.3 -1.5 -0.1 -2.1 -2.9 -1.5 -1.3 -2.3 -2.8
Severe depression (siblings) 2.3 2.6 5.3 -1.4 -2.3 -1.5 -1.2 1.3 -1.8 -1.2 -1.2 -1.9 -1.3 -2.0
Pack years adult smoking proportion 0.5 0.7 2.5 0.2 -0.6 -0.6 -0.8 1.2 -0.6 -0.7 -0.6 -0.7 -0.9 -1.6
Impedance of leg (right) 0.1 0.6 1.7 0.9 1.3 0.7 0.4 0.1 1.1 0.9 0.7 0.5 0.3 0.9
Leg fat-free mass (left) 1.7 8.8 18.7 -4.1 -4.3 -2.4 -1.3 -1.2 -4.2 -2.7 -1.4 -3.2 -1.6 -3.6
Trunk fat percentage 1.1 4.6 11.8 -2.4 -2.9 -2.0 -0.8 0.0 -3.0 -1.4 -1.4 -2.2 -1.3 -3.4
Hand grip strength (right) 0.6 1.8 5.4 -1.1 -0.4 0.9 1.8 -1.8 -0.5 1.4 1.5 -0.3 2.3 0.9
Townsend deprivation index at recruitment 1.6 2.2 5.0 -0.4 -1.5 -1.4 -1.3 1.8 -1.0 -1.3 -1.5 -1.3 -1.9 -2.2
Current tobacco smoking 2.4 3.9 10.6 -1.5 -2.1 -2.4 -1.2 0.4 -2.5 -1.4 -1.5 -2.4 -1.5 -3.3
Average weekly fortified wine intake 0.3 0.3 1.0 -0.3 -0.8 -0.0 -0.7 -0.3 -0.7 -1.0 -0.1 -0.6 -0.5 -0.3
Maternal smoking around birth 0.1 0.1 0.6 -0.3 -0.1 -0.1 0.0 -0.3 -0.2 -0.2 0.3 -0.6 -0.3 -0.8
Fed-up feelings 1.3 2.3 7.5 -0.5 -1.3 -1.2 -0.6 -1.0 -2.4 -1.5 0.2 -2.7 -1.4 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.7 10.8 -1.6 -2.9 -2.1 -1.4 0.2 -2.6 -2.2 -1.4 -2.1 -2.3 -3.3
Relative age voice broke 2.4 3.6 8.1 -2.1 -2.3 -2.0 -1.0 -0.0 -2.7 -1.7 -1.4 -2.0 -0.7 -2.9
Taking other prescription medications 1.0 1.6 3.9 -1.2 -1.7 -1.4 -0.6 -0.3 -1.5 -0.9 -0.7 -1.3 -1.3 -2.0
Age when periods started (menarche) 0.7 1.6 3.6 -0.2 -0.2 1.1 1.6 -0.8 0.9 1.4 0.5 1.7 1.9 1.9
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 0.1 -0.6 -0.2 0.4 0.4 0.1 -0.3 -0.5 0.5 0.5 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.9 -0.7 -1.9 -0.6 0.2 -1.2 -2.0 0.2 0.4 -1.6 -0.2 -1.7
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.3 -1.4 -0.8 0.8 1.3 -0.6 -0.9 1.1 1.4 -1.1 1.8 0.3
Qualifications: CSEs or equivalent 1.1 1.5 4.1 -0.2 0.3 1.4 1.4 -0.3 0.7 2.0 1.1 1.2 1.8 1.2
Serious illness, injury or assault to yourself 0.5 0.6 2.0 -1.4 -0.4 0.8 0.5 -1.2 0.6 -0.3 0.5 0.8 -0.1 0.5
High blood pressure 0.4 1.1 2.9 0.1 -0.4 -1.2 -1.5 1.7 -0.2 -1.1 -1.5 0.0 -1.1 -0.6
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.3 -0.8 -0.9 -0.0 0.8 -1.8 -1.3 -0.1 0.9 -1.5 0.3 -1.0
Multivitamins +/- minerals 0.6 0.8 2.2 -0.4 -0.9 -1.5 -0.2 0.2 -1.1 -0.2 -0.8 -1.2 -0.2 -1.5
Stomach or abdominal pain in last month 0.8 1.0 2.5 -0.8 -1.3 -0.6 -1.0 0.2 -1.5 -1.2 -0.2 -1.6 -0.9 -0.8
Supplements: Glucosamine 0.6 0.8 3.7 -0.3 -0.4 -0.5 -1.1 1.9 -0.1 -0.6 -1.4 0.2 -1.0 -0.5
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.7 -0.7 -1.4 -1.3 -1.4 0.6 -0.9 -1.6 -1.2 -0.7 -1.9 -1.3
Medication: Atenolol 0.4 0.5 2.3 -1.5 -0.7 0.5 0.2 -0.3 -0.4 0.8 0.4 -0.0 0.6 0.9
Medication: Levothyroxine sodium 0.2 0.3 0.8 0.6 0.1 -0.5 -0.8 0.5 0.3 -0.7 -0.6 0.4 -0.9 -0.5
Sitting height 1.5 11.0 27.6 -4.7 -4.1 -2.5 -0.6 -2.9 -5.2 -1.7 -0.3 -4.6 -0.5 -3.9
Chronic bronchitis/emphysema (father) 0.3 0.4 1.1 -0.1 0.0 -0.7 -1.1 0.6 -0.1 -0.9 -1.0 0.4 -0.6 -0.2
High blood pressure (mother) 0.2 0.2 1.1 0.2 0.4 0.1 -1.0 -0.1 0.3 -0.3 0.2 0.3 -1.0 0.4
Body mass index (BMI) 0.6 2.6 6.7 -0.9 -1.7 -1.8 -1.2 0.7 -2.0 -1.4 -1.6 -1.3 -1.6 -2.6
Impedance of leg (left) 0.4 1.8 3.2 0.9 1.6 1.5 1.2 -0.5 1.4 1.8 1.4 1.0 1.2 1.7
Leg predicted mass (left) 1.8 9.3 19.6 -4.2 -4.4 -2.5 -1.3 -1.3 -4.3 -2.8 -1.4 -3.3 -1.6 -3.7
Trunk fat mass 1.5 6.4 14.5 -3.0 -3.4 -2.3 -1.2 -0.1 -3.5 -1.9 -1.6 -2.7 -1.6 -3.8
Waist circumference 1.0 3.5 7.7 -1.3 -1.9 -2.2 -1.8 0.9 -2.1 -1.7 -2.1 -1.1 -2.0 -2.8
Number of incorrect matches in round 0.7 1.2 6.3 -1.1 -0.7 0.1 1.3 -2.5 -0.9 0.4 0.9 -0.5 0.8 -0.6
Past tobacco smoking 0.7 1.2 3.9 2.0 1.4 0.7 0.9 -1.0 0.6 1.6 1.1 0.9 0.6 0.0
Alcohol usually taken with meals 2.4 3.8 7.6 -1.2 -0.6 2.1 2.5 -2.8 0.6 1.5 2.4 0.7 2.6 2.5
Nervous feelings 0.1 0.3 1.5 -0.2 0.2 0.1 -0.2 -0.4 -0.5 -0.9 0.4 -1.2 -0.1 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.4 -0.2 -1.0 -0.4 -0.7 0.8 -0.2 -1.5 -0.6 -0.4 -1.2 -0.6
Hearing difficulty/problems with background noise 0.6 1.0 3.0 -1.0 -0.5 0.7 1.3 -1.7 -0.9 0.8 1.1 -0.8 1.1 0.1
Hair/balding pattern: Pattern 2 1.2 1.5 2.9 -0.2 -0.9 -1.5 -1.2 0.4 -1.0 -1.7 -1.6 -1.1 -1.6 -1.4
Had menopause 1.5 1.8 4.4 2.1 1.8 0.2 -0.9 1.3 1.8 0.0 -1.1 2.0 -1.0 0.7
Had other major operations 1.2 1.4 3.8 1.6 1.2 0.2 -0.6 1.5 1.9 -0.7 -0.9 1.8 -0.6 0.7
Forced vital capacity (FVC) 0.9 3.3 7.8 -1.4 -0.0 2.1 1.8 -2.7 0.2 1.2 2.3 0.3 2.8 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.3 -0.1 -1.2 -0.0 0.9 -1.5 -1.1 1.0 0.8 -0.8 0.4 -1.1
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.7 -1.4 -1.7 -1.3 -0.7 0.0 -1.9 -1.4 -0.8 -1.9 -1.0 -1.9
Qualifications: None of the above 1.3 2.7 4.8 2.1 1.5 -0.8 -2.1 2.0 1.4 -2.2 -1.4 1.0 -2.1 0.2
Financial difficulties in last 2 years 0.7 0.9 2.7 0.9 0.2 -1.0 -1.2 1.0 -0.2 -0.8 -0.9 -0.7 -1.6 -0.9
Mouth/teeth dental problems 1.4 2.2 4.2 -1.4 -0.5 1.4 2.0 -2.0 0.4 1.6 1.5 1.1 2.1 1.1
Heart attack 0.8 1.0 2.3 -1.5 -1.5 0.2 1.1 -0.5 -1.3 0.7 0.5 -1.1 1.1 -0.4
Allergy 0.9 2.0 5.3 0.7 1.2 1.1 0.5 0.9 1.9 1.5 0.1 2.3 1.4 2.2
Pain all over the body in last month 1.1 1.1 3.0 -0.9 -0.8 -0.8 -1.5 0.7 -0.6 -1.4 -1.1 -0.2 -1.7 -1.0
Diabetes (self-reported) 2.9 4.4 7.9 -1.2 -1.5 -2.8 -1.9 0.2 -2.4 -2.2 -2.3 -2.1 -2.4 -2.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.5 0.1 -0.2 -0.5 0.7 -1.6 -1.0 0.3 0.5 -0.9 0.3 -0.6
Medication: Ramipril 0.2 0.2 0.6 -0.8 -0.4 0.1 -0.6 0.1 -0.3 -0.4 -0.0 -0.5 -0.7 0.3
Medication: Simvastatin 0.3 0.4 1.0 -0.6 -1.0 -0.3 -0.4 0.7 -0.5 -0.6 -0.3 -0.4 -0.6 -0.9
Fluid intelligence score 0.2 0.4 1.3 -1.0 -1.1 0.0 -0.5 1.1 -0.4 0.2 -0.1 -0.4 0.3 -0.2
Illnesses of siblings 3.6 5.1 9.5 0.8 1.9 2.7 3.1 -1.6 1.6 2.6 2.6 0.9 3.0 2.5
Neuroticism score 0.7 1.4 3.3 -0.2 -0.9 -1.0 -1.3 0.8 -1.2 -1.6 -0.6 -1.6 -1.8 -1.2
Weight 1.5 7.2 14.1 -3.0 -3.6 -2.4 -1.6 -0.2 -3.7 -2.4 -1.7 -2.8 -2.0 -3.8
Impedance of arm (right) 0.1 0.6 1.3 -1.1 -1.1 0.3 1.1 -0.6 -0.4 0.4 0.8 -1.0 0.5 -0.6
Arm fat percentage (right) 1.1 4.4 11.9 -1.4 -2.5 -2.3 -1.3 1.0 -2.5 -1.8 -2.0 -1.8 -1.9 -3.4
Trunk fat-free mass 0.9 5.2 10.0 -2.9 -3.1 -2.0 -1.6 -0.8 -3.2 -2.6 -1.4 -2.2 -1.7 -2.5
Hip circumference 1.3 5.5 10.8 -2.7 -3.1 -2.3 -1.3 -0.5 -3.3 -2.0 -1.5 -2.2 -1.8 -3.3
Time employed in main current job 0.9 1.0 3.1 1.2 0.2 -1.0 -1.3 1.8 0.1 -0.3 -1.3 0.1 -1.2 -0.1
Alcohol intake versus 10 years previously 0.5 0.8 2.9 1.0 1.2 -0.7 0.2 0.5 -0.9 0.7 -0.0 -1.7 0.3 -0.9
Father’s age at death 0.3 0.5 1.2 1.1 0.9 -0.9 -0.6 1.0 0.2 -0.4 -0.7 -0.3 -0.4 -0.1
Worrier / anxious feelings 1.0 1.8 3.2 1.7 1.6 0.2 -1.4 1.7 1.8 -0.6 -0.8 1.5 -1.0 1.5
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 8.5 0.5 -0.2 -1.9 -2.3 1.6 -1.2 -1.9 -1.8 -1.6 -2.9 -2.0
Falls in the last year 0.4 0.6 2.5 -1.6 -1.4 -0.4 -0.3 -0.0 -0.3 -0.6 -0.9 0.4 -0.3 -0.0
Hair/balding pattern: Pattern 3 1.8 2.7 6.4 2.0 2.5 1.2 0.9 0.4 1.7 1.7 1.0 1.5 1.4 2.4
Number of live births 0.5 0.7 1.7 1.3 1.2 0.8 -0.4 0.6 1.2 -0.2 0.1 1.1 -0.3 0.6
Forced expiratory volume in 1-second (FEV1) 1.2 4.1 9.0 -0.8 0.2 2.2 2.2 -2.6 0.5 2.2 2.5 0.7 3.0 2.6
Pulse rate 0.3 0.4 1.6 -0.2 -1.2 -0.7 0.3 -0.3 -0.6 0.1 -0.8 0.2 -0.2 -1.3
Happiness 0.1 0.1 0.7 0.1 -0.1 -0.3 -0.4 -0.5 -0.0 -0.8 -0.3 0.2 -0.5 -0.0
Noisy workplace 0.2 0.3 0.6 -0.7 -0.8 0.3 0.4 -0.1 -0.6 0.1 0.4 -0.6 0.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.9 -0.1 0.1 0.5 0.6 -0.5 0.4 0.5 0.4 0.2 0.7 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.8 -0.2 -0.1 1.2 0.8 -0.1 1.1 0.6 0.8 1.3 0.7 1.3
Mouth/teeth dental problems: Dentures 0.7 1.1 3.9 -0.3 -1.2 -1.1 -0.5 0.2 -1.2 -1.3 -0.7 -1.2 -0.8 -2.0
Asthma 1.6 3.2 8.0 0.3 -0.4 -1.8 -2.1 1.5 -1.1 -2.0 -1.8 -1.2 -2.8 -2.6
Medication: Ibuprofen (e.g. Nurofen) 3.1 3.9 7.9 -0.8 -1.7 -2.8 -1.9 1.1 -2.3 -1.6 -2.5 -1.6 -1.9 -2.6
Medication: Cholesterol lowering 1.0 1.6 6.7 -2.2 -2.6 -0.6 0.2 -0.5 -1.6 -0.4 -0.1 -0.9 -0.1 -1.4
Depression (self-reported) 2.2 2.6 6.2 -1.4 -2.3 -1.9 -0.8 0.3 -1.8 -1.3 -1.1 -1.5 -1.4 -2.5
Medication: Lansoprazole 0.2 0.2 1.3 1.1 0.8 -0.2 -0.2 0.2 0.2 -0.6 -0.1 -0.1 -0.4 -0.2
Prospective memory result 1.3 1.6 3.6 0.4 0.8 1.2 1.9 -0.7 1.3 1.5 1.2 1.1 1.7 1.4
Lung cancer (father) 0.4 0.4 2.1 1.5 0.7 0.3 0.4 0.8 0.4 0.9 0.4 -0.1 0.1 -0.3
Illnesses of mother 1.0 1.2 5.2 0.2 -0.2 0.5 1.9 -0.7 -0.6 1.2 1.1 -0.7 2.3 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 10.1 -1.4 -0.4 1.9 2.4 -2.6 -0.2 1.9 2.6 -0.2 3.2 2.0
Pulse wave Arterial Stiffness index 1.4 1.6 4.0 0.5 -0.4 -2.0 -0.8 1.6 -1.4 0.2 -1.8 -0.9 -0.7 -1.9
Impedance of arm (left) 0.1 0.6 1.9 -1.4 -1.2 0.4 0.7 -0.5 -0.4 0.1 0.7 -1.0 0.3 -0.7
Arm fat mass (right) 1.2 4.9 11.7 -2.1 -2.9 -2.0 -1.3 0.3 -3.0 -1.9 -1.6 -2.2 -1.8 -3.4
Trunk predicted mass 1.0 5.4 10.7 -3.0 -3.1 -2.0 -1.6 -0.9 -3.3 -2.6 -1.4 -2.3 -1.6 -2.6
Standing height 0.9 8.8 26.7 -5.2 -4.5 -1.2 -0.6 -2.6 -4.1 -2.2 0.1 -3.4 -0.6 -2.7
Length of working week for main job 1.0 1.1 4.2 -0.7 -0.2 -1.0 0.4 -1.4 -1.7 0.2 0.6 -2.1 0.6 -0.6
Exposure to tobacco smoke at home 0.1 0.1 0.3 -0.5 0.5 0.1 0.6 -0.5 0.1 0.4 0.4 -0.1 0.3 0.0
Breastfed as a baby 0.4 0.6 1.3 0.9 1.1 0.0 -0.7 0.9 0.8 -0.9 -0.7 0.5 -0.4 0.6
Tense / ‘highly strung’ 0.2 0.4 1.3 -0.1 -0.2 1.1 0.1 -0.6 0.8 -0.6 0.6 0.7 -0.4 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 7.1 -1.3 -2.4 -1.4 -1.0 -0.1 -2.4 -2.2 -0.6 -2.7 -1.8 -2.6
Hair/balding pattern: Pattern 4 0.4 1.0 3.4 1.8 1.7 -0.4 -0.8 1.1 0.9 -0.7 -0.8 0.2 -1.0 0.3
Birth weight of first child 2.6 4.7 11.4 0.8 1.5 2.3 2.1 -1.1 2.8 2.0 1.5 2.6 2.4 3.4
Peak expiratory flow (PEF) 2.4 5.6 12.7 -0.1 1.1 2.4 2.9 -2.3 1.4 2.8 2.4 1.2 3.6 3.3
Pulse wave reflection index 1.2 1.5 4.6 0.9 1.7 0.9 1.4 -0.6 0.6 2.1 1.1 0.5 1.5 1.3
Ever highly irritable/argumentative for 2 days 1.2 1.5 3.6 -1.1 -1.4 -0.9 -1.0 0.5 -1.6 -1.0 -0.4 -1.9 -1.1 -1.6
Loud music exposure frequency 0.5 0.6 1.3 0.1 0.2 0.9 1.2 -0.8 0.1 1.1 1.1 -0.1 0.9 0.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.9 0.8 1.0 0.1 0.1 0.3 1.0 0.9 -0.5 1.2 0.5 1.4
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 5.1 1.3 0.7 -0.4 -2.1 2.3 1.1 -1.5 -1.7 1.2 -2.0 0.2
Blood clot in the leg (DVT) 1.8 2.3 5.0 -0.1 -0.5 -2.0 -1.8 1.0 -1.1 -2.2 -1.2 -1.6 -2.0 -1.8
Medication: Paracetamol 1.2 2.1 6.2 -0.7 -1.3 -1.9 -0.7 0.2 -1.7 -1.4 -1.4 -1.3 -1.2 -2.5
Headache pain in last month 0.5 0.9 1.9 0.4 -0.7 -1.1 -1.0 1.2 -0.3 -1.0 -1.4 -0.4 -1.2 -1.0
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 5.6 2.1 2.4 0.3 -0.6 0.4 1.5 -0.5 -0.1 0.8 -0.5 1.0
Glaucoma (self-reported) 1.2 1.5 3.2 0.6 0.8 1.3 1.8 -1.3 0.7 1.4 1.6 0.5 1.5 1.0
Gout (self-reported) 1.3 1.7 4.4 0.0 0.0 -1.1 -1.8 1.8 0.4 -1.9 -2.1 1.2 -1.2 -0.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.4 -0.4 -1.1 -0.4 -0.9 0.8 0.0 -1.1 -0.8 0.7 -1.2 -0.6
Medication: Amlodipine 0.3 0.5 1.4 0.2 0.2 1.2 0.2 0.4 0.7 0.4 0.9 0.6 0.9 0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 -0.3 -0.0 -0.7 -0.2 -1.1 -0.6 -0.8 -0.4 -0.5 -0.9 -1.3
Birth weight 1.0 2.2 6.1 0.1 -0.0 0.9 2.2 -2.2 0.1 1.9 1.7 0.1 2.5 1.4
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.4 0.8 1.1 -0.6 -0.1 0.2 -0.2 -0.2 0.2 -1.2 -0.5 -1.1
High blood pressure (siblings) 2.7 3.9 10.4 -0.5 -1.0 -2.0 -3.2 2.3 -0.5 -2.2 -2.5 0.2 -3.0 -1.3
Forced vital capacity (FVC), Best measure 1.0 3.7 10.4 -1.5 -0.2 1.8 2.3 -2.6 -0.3 1.8 2.6 -0.4 3.2 1.7
Body fat percentage 1.1 4.2 11.2 -1.5 -2.3 -2.3 -1.3 0.7 -2.5 -1.7 -1.8 -1.8 -1.8 -3.3
Leg fat percentage (right) 0.9 3.4 8.5 -0.3 -1.1 -2.3 -1.8 1.5 -1.9 -1.5 -2.0 -1.4 -2.2 -2.9
Arm fat-free mass (right) 0.7 3.8 8.3 -2.8 -2.6 -1.4 -1.0 -1.4 -2.9 -2.0 -0.8 -1.9 -1.0 -2.1
Exposure to tobacco smoke outside home 2.6 3.4 8.2 1.5 2.4 1.5 1.1 0.4 2.9 1.5 0.9 2.5 1.2 2.7
Comparative body size at age 10 0.3 0.8 2.6 -0.8 -1.6 -0.7 -0.5 0.5 -0.7 -0.7 -1.0 -0.1 -0.9 -1.4
Number of full brothers 0.4 0.5 3.2 0.3 -0.2 0.9 0.0 0.2 1.2 0.1 -0.4 1.8 -0.1 0.6
Worry too long after embarrassment 0.7 1.2 2.7 -1.6 -1.6 -0.1 0.2 -1.1 -1.6 -0.2 0.5 -1.6 -0.1 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 4.3 5.6 13.4 -2.0 -3.2 -2.0 -0.6 -0.2 -3.5 -1.4 -0.5 -3.7 -1.5 -3.7
Wheeze or whistling in the chest in last year 2.3 4.0 12.4 -0.3 -1.2 -2.5 -1.5 1.8 -1.9 -1.9 -1.8 -2.1 -1.9 -3.5
Number of children fathered 0.5 0.6 1.8 -1.3 -1.0 -0.1 0.2 -0.4 -1.0 -0.1 0.5 -1.2 0.5 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.8 0.7 0.4 -0.6 -0.2 0.4 0.5 -0.0 -0.9 0.8 -0.4 0.6
Age at first live birth 1.1 2.0 5.1 -2.1 -1.3 1.1 1.5 -2.3 -1.1 0.9 1.4 -0.7 1.5 0.9
Pulse wave peak to peak time 1.1 1.3 3.5 -0.8 0.1 1.9 0.5 -1.5 1.1 -0.4 1.7 0.7 0.5 1.7
Health satisfaction 1.3 1.6 4.9 -0.5 -0.2 -1.8 -1.1 0.2 -1.1 -1.1 -1.4 -0.9 -1.7 -2.2
Shortness of breath walking on level ground 6.0 7.2 17.0 -1.6 -1.6 -2.8 -2.3 1.3 -2.6 -3.4 -2.1 -2.9 -3.2 -4.1
Qualifications: College or University degree 1.5 4.8 13.4 -3.7 -3.0 1.9 2.1 -2.5 -1.4 0.9 2.3 -1.7 2.1 0.6
Eye problems/disorders: None of the above 0.9 1.0 1.9 1.3 1.2 0.6 -0.6 1.2 1.4 0.7 -0.1 1.4 -0.6 1.0
Mouth/teeth dental problems: Loose teeth 0.9 1.0 4.2 -2.0 -1.8 0.4 -0.3 -0.2 -1.1 -0.7 0.4 -1.1 -0.1 -0.6
Emphysema/chronic bronchitis 1.0 1.1 2.7 -0.9 -0.5 1.0 1.2 -0.7 -0.7 1.0 1.6 -1.2 1.5 -0.1
Medication for pain relief, constipation, heartburn 1.1 2.0 4.5 1.2 1.7 1.6 0.8 -0.8 1.8 1.0 1.5 1.3 1.1 2.1
Neck or shoulder pain in last month 0.5 0.7 2.1 1.4 0.8 -0.4 -0.4 1.3 -0.3 0.2 -0.3 -1.1 -0.9 -0.7
Medication: Blood pressure 0.5 0.9 3.6 -1.9 -1.6 -0.3 0.3 -0.2 -1.3 0.1 0.2 -1.1 0.3 -0.6
Angina (self-reported) 0.1 0.2 0.6 -0.8 -0.2 -0.1 -0.2 0.4 -0.4 -0.7 -0.4 -0.4 -0.3 -0.2
Migraine (self-reported) 0.9 1.1 2.7 0.6 1.0 1.4 0.8 -0.4 1.0 1.1 1.2 0.6 1.2 1.6
Medication: Ibuprofen 2.5 3.0 5.6 -0.8 -1.4 -2.4 -1.7 1.0 -2.0 -1.6 -2.3 -1.5 -1.4 -2.1
Medication: Allopurinol 0.9 1.2 3.4 -0.2 -0.2 -1.1 -1.3 1.3 0.4 -1.3 -1.9 1.2 -0.9 -0.7
Medication: Omeprazole 0.1 0.1 0.4 0.6 0.2 -0.3 -0.4 0.4 -0.3 -0.3 -0.3 -0.1 0.3 -0.1
Medication: Seretide 50 evohaler 0.4 0.5 2.9 0.5 -0.2 -0.5 -0.8 1.7 -0.3 0.0 -0.7 -0.4 -0.4 -0.4
Mean time to correctly identify matches 0.0 0.1 0.3 0.1 0.1 0.2 0.1 0.4 0.5 -0.2 0.1 0.3 0.3 0.5
Heart disease (mother) 0.7 0.8 2.1 0.9 1.3 0.5 -0.5 1.1 1.2 0.0 -0.2 0.8 -0.5 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 2.5 0.5 -0.1 0.8 1.6 -1.1 -0.1 0.8 1.1 -0.4 1.3 0.1
Whole body fat mass 1.4 5.8 12.9 -2.4 -3.0 -2.4 -1.6 0.4 -3.2 -2.1 -1.9 -2.3 -2.0 -3.6
Leg fat mass (right) 1.3 5.2 12.6 -1.6 -2.4 -2.6 -1.7 0.7 -2.9 -1.9 -2.1 -2.1 -2.2 -3.5
Arm predicted mass (right) 0.9 4.4 8.7 -2.6 -2.6 -1.9 -1.5 -1.0 -2.9 -2.4 -1.3 -2.0 -1.6 -2.4
Pulse rate, automated reading 0.1 0.3 1.1 -0.7 -1.0 0.1 0.4 -0.3 -0.0 0.3 -0.3 0.6 -0.1 -0.8
Alcohol intake frequency. 0.1 0.3 1.3 1.2 0.5 -0.2 0.4 -0.6 -0.0 0.7 0.2 0.2 0.1 -0.2
Comparative height size at age 10 1.2 6.5 14.0 -3.7 -3.5 -1.0 0.3 -3.1 -3.7 -1.4 0.7 -3.3 -0.1 -2.8
Number of full sisters 0.5 0.6 1.2 0.7 0.6 -0.2 -0.9 0.8 0.9 0.3 -0.9 1.1 -0.6 1.0
Suffer from ‘nerves’ 0.2 0.3 1.0 -1.0 -0.6 0.1 0.0 -0.6 -0.2 -0.9 0.4 -0.6 -0.4 -0.3
Overall health rating 2.6 5.7 14.2 -0.4 -1.1 -2.6 -2.8 1.8 -1.7 -2.6 -2.9 -1.3 -3.8 -3.0
Chest pain or discomfort 2.0 3.0 5.2 -1.9 -1.4 -1.3 -2.1 1.4 -1.6 -2.3 -1.3 -1.5 -2.0 -1.9
Had major operations 3.2 3.7 8.2 -2.2 -2.7 -2.0 -0.3 -0.7 -2.8 -1.7 -0.8 -2.9 -0.4 -2.1
Age at last live birth 0.5 0.7 2.1 -1.5 -1.0 0.1 0.3 -1.4 -1.2 0.2 0.3 -0.7 0.1 0.0
Family relationship satisfaction 1.4 1.7 3.6 -1.5 -1.6 -1.3 0.2 -1.3 -1.7 -0.5 -0.2 -1.9 -0.7 -1.7
Leg pain on walking 2.7 3.4 7.7 0.1 -0.8 -2.1 -2.1 1.4 -1.0 -2.5 -2.2 -0.7 -2.8 -2.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.5 1.0 0.2 -1.0 -0.9 1.6 0.5 0.2 -1.3 1.2 -0.7 -0.5
Commuting to job workplace: Car/motor vehicle 2.7 3.1 7.1 2.7 2.6 1.5 1.1 -0.7 2.3 1.6 1.3 1.9 0.6 1.9
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.9 -0.2 -0.7 -1.4 -1.7 1.1 -1.1 -1.0 -1.6 -0.2 -0.8 -1.1
Medication: Aspirin 0.4 0.6 2.3 -1.5 -1.1 0.4 0.7 -0.7 -0.7 0.3 0.5 -0.6 0.2 -0.3
Supplements: Vitamin C 0.6 0.7 1.4 1.1 0.4 -0.7 -0.8 0.8 0.8 -0.6 -1.0 0.8 -1.2 0.5
Knee pain experienced in last month 0.2 0.3 0.8 0.0 -0.5 -0.8 -0.1 0.7 -0.5 -0.3 -0.9 -0.1 -0.6 -0.8
Hypertension (Self-reported) 0.6 1.6 4.3 -0.0 -0.5 -1.4 -1.8 2.1 -0.1 -1.4 -1.9 0.3 -1.4 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.8 2.2 0.8 1.0 0.9 0.1 1.5 0.6 0.9 0.3 0.4 1.0 1.1
Illnesses of father: Heart disease 0.4 0.5 2.1 -1.4 -0.7 0.3 0.5 -1.2 -0.4 -0.3 0.7 -0.6 0.2 -0.4
Illnesses of siblings: Diabetes 4.5 5.5 13.0 -0.7 -1.4 -3.6 -1.9 0.6 -2.7 -2.4 -2.6 -2.4 -2.1 -3.4
Smoking status: Previous 0.4 0.6 1.5 -1.0 -0.6 -0.7 -0.8 0.9 -0.2 -1.2 -1.2 -0.3 -0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 4.3 -2.1 -2.1 -0.5 0.5 -1.9 -2.0 -1.1 0.3 -1.9 -0.2 -1.4
Whole body fat-free mass 1.2 6.6 13.3 -3.5 -3.6 -2.1 -1.4 -1.1 -3.6 -2.6 -1.4 -2.6 -1.6 -3.0
Leg fat-free mass (right) 1.4 7.5 17.6 -4.1 -4.2 -1.8 -0.7 -1.8 -4.0 -2.2 -0.7 -3.0 -1.0 -3.1
Arm fat percentage (left) 1.1 4.4 12.1 -1.5 -2.5 -2.2 -1.3 0.9 -2.4 -1.8 -1.9 -1.9 -2.0 -3.5
Average weekly red wine intake 1.0 1.5 3.3 -0.8 -0.3 1.4 1.8 -1.3 0.7 1.2 1.5 0.6 1.6 1.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.9 0.7 0.9 0.2 0.3 1.0 -0.4 0.4 0.3 0.2 1.0
Mood swings 0.7 1.3 2.8 -0.5 -1.0 -1.2 -0.7 -0.1 -1.7 -1.3 -0.6 -1.7 -1.2 -1.3
Loneliness, isolation 1.0 1.3 3.2 -0.2 -0.6 -0.9 -1.5 1.2 -0.8 -1.8 -0.9 -1.1 -1.5 -1.3
Long-standing illness, disability or infirmity 2.5 3.8 7.4 -1.4 -2.1 -1.6 -1.5 0.1 -2.3 -2.1 -0.8 -2.7 -2.5 -2.6
Ever had bowel cancer screening 0.7 0.8 2.7 0.2 0.0 -0.7 -1.0 1.4 0.1 -1.7 -1.1 -0.0 -0.8 -0.8
Diabetes diagnosed by doctor 3.4 5.5 11.2 -1.6 -2.0 -3.3 -1.6 -0.0 -3.1 -1.9 -2.2 -2.8 -2.0 -3.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.9 0.1 -0.3 0.2 -0.1 -0.6 0.9 -0.3 -0.2 1.4 -0.9 -0.2
Friendships satisfaction 0.6 0.7 2.9 -1.2 -0.5 0.1 0.6 -1.7 -0.9 0.5 0.8 -0.7 0.6 -0.0
Qualifications: nursing, teaching 0.7 1.1 2.3 -0.8 -0.3 1.3 1.1 -1.1 -0.2 1.5 1.5 -0.5 1.1 0.9
Commuting to job workplace: Walk 0.4 0.4 1.7 -0.5 -0.9 -0.4 -0.1 0.1 -1.1 -0.2 0.0 -1.3 0.2 -0.5
Eye problems/disorders: Cataract 0.5 0.6 2.1 -0.7 -1.5 -0.7 0.2 -0.6 -0.9 -0.8 -0.5 -0.3 0.5 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 7.3 1.8 2.7 0.0 -0.0 0.7 1.2 0.3 0.2 -0.0 0.6 1.6
Medication for cholesterol 0.8 1.2 5.9 -1.2 -0.4 0.1 1.6 -2.4 -0.4 0.9 0.7 0.4 1.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.0 -0.6 -0.4 -0.8 -0.5 -0.1 -0.6 -1.4 -0.8 -0.3 -0.6 -0.7
Back pain experienced in last month 2.4 3.5 9.0 -1.5 -2.2 -1.9 -1.1 0.4 -2.5 -1.3 -1.2 -2.3 -1.7 -3.0
Mineral and other dietary supplements 0.7 1.0 2.7 0.3 0.2 1.5 1.2 -1.1 0.2 0.6 1.6 -0.1 1.4 1.0
Breast cancer (self-reported) 0.6 0.8 3.3 0.4 0.7 0.2 0.1 -0.1 1.4 -0.5 -0.4 1.8 0.2 1.5
Asthma (self-reported) 1.7 3.4 8.1 0.2 -0.6 -2.0 -2.1 1.4 -1.2 -2.1 -1.9 -1.3 -2.8 -2.7
Osteoporosis (self-reported) 0.4 0.5 2.3 -1.5 -1.2 -0.0 -0.3 -0.1 -0.7 -0.7 -0.4 -0.2 -0.1 -0.5
Osteoarthritis (self-reported) 1.6 2.1 4.1 1.7 1.2 1.8 0.6 1.0 2.0 1.6 0.7 1.9 0.6 1.6
Medication: Aspirin 0.4 0.6 2.5 -1.6 -1.3 0.6 0.6 -0.6 -0.6 0.3 0.6 -0.3 0.4 -0.1
Medication: Gliclazide 0.7 0.7 1.7 -0.0 -0.2 -1.2 -0.8 0.3 -0.7 -0.8 -1.1 -0.6 -1.1 -1.3
Illnesses of father: None of the above (group 1) 0.3 0.4 1.4 0.5 0.4 0.7 0.1 0.2 0.9 0.3 0.3 1.0 0.4 1.2
Smoking status: Current 2.1 3.4 7.3 -2.1 -2.3 -2.0 -1.1 -0.0 -2.4 -1.4 -1.1 -2.2 -1.2 -2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 9.2 -0.0 0.7 2.2 2.1 -1.3 1.6 2.3 1.8 2.0 2.8 3.0
Whole body water mass 1.1 6.5 13.0 -3.4 -3.5 -2.1 -1.4 -1.1 -3.6 -2.6 -1.4 -2.6 -1.6 -3.0
Leg predicted mass (right) 1.4 7.6 17.5 -4.1 -4.2 -1.9 -0.8 -1.6 -4.0 -2.3 -0.9 -3.0 -1.1 -3.2
Arm fat mass (left) 1.3 5.3 12.5 -2.2 -3.0 -2.1 -1.4 0.3 -3.0 -2.1 -1.7 -2.2 -1.9 -3.5
Number of self-reported non-cancer illnesses 0.6 1.1 2.6 -0.2 -1.2 -0.9 -1.0 1.3 -0.3 -1.5 -1.2 -0.3 -1.6 -1.1
Average weekly champagne plus white wine intake 0.2 0.3 0.7 -0.4 -0.7 0.2 0.6 -0.5 -0.6 0.1 0.5 -0.8 0.6 -0.2
Miserableness 1.9 3.3 6.2 -0.3 -1.8 -2.2 -1.4 0.5 -2.4 -1.7 -1.4 -2.5 -1.9 -2.5
Guilty feelings 0.8 1.2 2.7 -1.0 -1.0 -0.9 -1.1 0.4 -1.0 -1.6 -1.0 -1.0 -1.5 -1.3
Wears glasses or contact lenses 0.2 0.3 0.8 -0.3 -0.3 -0.1 -0.8 0.9 -0.5 -0.6 -0.4 -0.4 -0.3 0.7
Ever taken oral contraceptive pill 1.6 1.8 4.5 -1.3 -2.1 -0.9 1.4 -0.9 -1.7 0.8 0.2 -1.3 0.6 -2.0
Hearing aid user 2.6 2.9 5.4 1.1 -0.0 -1.9 -2.3 2.2 -1.0 -1.9 -1.7 -1.3 -2.1 -1.9
Mother’s age at death 0.7 0.9 2.6 -1.6 -1.4 0.2 1.0 -1.3 -0.6 -0.3 0.6 -0.5 1.0 -0.3
Financial situation satisfaction 2.7 3.3 9.5 0.3 0.4 -2.1 -2.3 0.6 -0.8 -2.8 -1.9 -1.2 -3.1 -1.7
Tinnitus: Yes, now most or all of the time 1.7 2.0 5.3 -1.0 -1.6 -0.6 0.1 -1.5 -2.0 -1.1 0.5 -2.3 -1.0 -1.9
Commuting to job workplace: Public transport 0.9 1.0 2.6 -1.6 -1.5 -0.1 0.7 -1.4 -1.1 -0.7 0.5 -1.3 0.2 -0.3
Eye problems/disorders: Glaucoma 0.2 0.2 0.7 0.7 0.4 0.6 0.4 -0.1 0.6 0.8 0.4 0.5 0.1 0.5
Medication: Blood pressure 0.3 0.6 1.6 1.0 1.1 0.2 -1.0 1.3 0.8 -0.3 -0.3 0.4 -0.6 0.7
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.5 -0.5 -1.5 -0.3 -0.9 1.6 -1.0 -0.3 -0.4 -0.9 -0.6 -0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.9 0.6 0.9 -2.0 -1.4 1.2 0.0 -0.7 -1.8 -0.1 -1.5 -0.4
High cholesterol (Self-reported) 0.2 0.4 1.1 0.0 -0.6 1.0 0.1 0.8 1.0 -0.1 0.0 1.0 -0.2 0.4
Medication: Bendroflumethiazide 0.2 0.4 0.9 0.2 0.7 0.1 1.0 -0.9 -0.0 0.8 0.6 -0.2 0.7 -0.0
Medication: Paracetamol 1.7 2.7 7.6 -1.1 -1.6 -2.0 -1.1 0.6 -1.7 -1.8 -1.6 -1.3 -1.6 -2.8
Medication: Lisinopril 0.5 0.6 1.7 -0.1 -0.9 -0.8 -0.3 0.0 -1.2 -0.4 -0.3 -1.2 -0.5 -1.3
Medication: Atorvastatin 0.6 0.7 1.2 -0.8 -0.8 -0.9 -1.1 0.7 -0.6 -1.1 -1.1 -0.4 -0.9 -0.4
Illnesses of father: High blood pressure 0.5 0.6 1.9 -1.4 -0.8 -0.4 -0.0 -0.3 -0.9 -1.2 -0.0 -1.4 -0.0 -0.3
Alcohol drinker status: Never 0.9 1.1 2.9 0.9 0.8 1.4 -0.4 0.3 1.5 0.2 0.5 1.7 0.0 1.7
Ever smoked 0.6 1.0 3.5 -1.9 -1.6 -0.5 -0.3 0.8 -0.8 -1.0 -0.6 -1.3 0.2 -0.1
Basal metabolic rate 1.3 7.4 14.6 -3.6 -3.8 -2.3 -1.5 -1.0 -3.8 -2.7 -1.4 -2.8 -1.7 -3.3
Leg fat percentage (left) 0.6 2.3 6.0 -0.2 -0.9 -2.0 -1.4 1.2 -1.6 -1.1 -1.7 -1.1 -1.8 -2.4
Arm fat-free mass (left) 0.9 4.6 9.1 -2.8 -2.9 -1.9 -1.4 -0.8 -3.0 -2.3 -1.3 -2.0 -1.4 -2.4
Number of operations (self-reported) 0.3 0.4 1.1 0.5 -0.7 -1.0 0.2 0.7 -0.3 -0.6 -0.7 -0.4 0.1 -0.9
Average weekly beer plus cider intake 1.6 2.3 7.1 -1.2 -1.6 -1.5 -0.3 0.1 -2.3 -1.6 -0.4 -2.7 -0.0 -2.0
Irritability 1.5 2.5 4.4 -1.5 -2.1 -1.4 -1.2 0.5 -2.0 -1.7 -0.8 -2.0 -1.6 -1.7
Risk taking 0.3 0.4 1.0 -0.1 -0.7 -0.8 -0.7 0.6 -0.3 -0.4 -1.0 0.1 -0.7 -0.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.2 -1.0 -1.4 -1.1 -0.0 -0.6 -1.3 -0.8 -0.7 -0.6 -0.4 -1.5
Fractured/broken bones in last 5 years 0.2 0.3 0.8 -0.4 0.2 -0.7 -0.6 0.3 0.1 -0.2 -0.8 0.4 -0.9 -0.8
Age started oral contraceptive pill 0.6 0.7 2.6 1.4 1.6 -0.2 -0.5 0.0 1.1 -0.5 -0.4 0.8 -0.9 0.4
Diastolic blood pressure, automated reading 0.5 1.7 3.7 -0.6 -1.1 -1.2 -1.8 1.2 -0.4 -1.6 -1.9 0.4 -1.7 -1.1
Ever depressed for a whole week 1.9 2.4 4.4 -1.4 -1.8 -1.3 -1.1 -0.0 -1.9 -1.9 -0.7 -2.1 -1.5 -1.9
Unable to work because of sickness or disability 1.2 1.5 2.9 -1.3 -1.2 -1.3 -1.1 0.3 -1.3 -1.6 -0.9 -1.7 -1.0 -1.2
Commuting to job workplace: Cycle 0.6 0.7 2.2 -1.0 -1.5 -0.5 -1.1 0.3 -0.7 -0.5 -1.1 0.3 -0.9 -0.4
Myopia 1.1 1.5 3.0 0.9 1.4 1.4 1.2 -0.8 1.6 1.2 1.2 1.1 0.8 1.7
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.2 0.2 0.5 1.0 1.4 -1.5 0.3 1.2 1.3 0.1 1.1 0.7
Cholesterol lowering medication 0.6 1.0 2.6 1.1 1.2 0.8 -0.8 1.6 1.3 -0.3 -0.0 0.6 -0.8 1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 0.2 -0.2 -0.7 -0.8 0.4 -0.5 -0.7 -0.8 -0.1 -0.3 -0.6
Pain experienced in last month 1.2 2.0 4.3 -0.2 0.3 1.5 1.6 -2.0 0.9 0.9 1.7 1.0 2.1 1.6
Supplements: Calcium 0.8 0.8 1.8 -1.3 -1.3 -1.1 -0.5 -0.1 -0.7 -0.8 -1.2 -0.1 -0.8 -1.0
Basal cell carcinoma (self-reported) 1.2 1.4 3.9 1.1 1.7 0.8 -0.7 1.0 2.0 -0.3 -0.2 1.7 -0.3 1.5
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.7 -1.6 -1.6 0.3 1.4 -0.8 -1.4 0.7 0.7 -1.1 1.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 3.9 -0.1 -0.5 -1.9 -1.5 0.7 -1.1 -2.0 -1.1 -1.5 -1.6 -1.7
Heart disease (siblings) 0.6 0.7 1.6 0.7 0.2 -0.5 -0.9 1.1 0.5 -0.9 -0.9 0.8 -1.3 -0.9
Alcohol drinker status: Previous 2.2 2.5 6.9 -0.0 -0.7 -2.6 -1.4 0.7 -1.9 -1.0 -1.8 -1.8 -1.1 -2.4
Pack years of smoking 0.6 0.9 2.6 0.2 -0.6 -0.6 -1.0 1.4 -0.7 -0.9 -0.6 -0.8 -1.0 -1.6
Impedance of whole body 0.1 0.6 1.4 -0.4 -0.0 0.9 1.1 -0.6 0.4 1.0 1.2 -0.1 0.9 0.4
Leg fat mass (left) 1.1 4.4 10.4 -1.5 -2.3 -2.4 -1.6 0.6 -2.7 -1.8 -2.0 -1.8 -2.0 -3.2
Arm predicted mass (left) 0.9 4.4 8.2 -2.5 -2.7 -1.8 -1.6 -0.8 -2.9 -2.4 -1.3 -1.8 -1.7 -2.4