Hub : Genes

SH3BGRL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1140 0.0420 7.2e-04 0.182 0.009 0.167 0.173 0.181 1.4e-21 2.6e-02 7.5e-20 1.3e-20 1.7e-21
2 GTEx Adipose Subcutaneous 0.1710 0.0550 1.3e-04 0.142 NA 0.118 NA 0.140 1.0e-11 NA 6.6e-10 NA 1.6e-11
3 GTEx Adipose Visceral Omentum 0.1570 0.0580 3.4e-03 0.104 NA 0.068 NA 0.103 5.0e-06 NA 2.1e-04 NA 5.6e-06
4 GTEx Colon Transverse 0.1130 0.0430 3.9e-03 0.012 NA 0.050 NA 0.042 8.1e-02 NA 2.1e-03 NA 4.2e-03
5 GTEx Esophagus Mucosa 0.1340 0.0470 2.6e-03 0.030 NA 0.033 NA 0.054 4.4e-03 NA 2.9e-03 NA 1.8e-04
6 GTEx Lung 0.2127 0.0582 2.4e-05 0.099 NA 0.080 NA 0.096 5.1e-08 NA 1.0e-06 NA 8.1e-08
7 GTEx Nerve Tibial 0.1809 0.0610 2.4e-04 0.018 NA 0.034 NA 0.036 1.7e-02 NA 1.8e-03 NA 1.4e-03
8 ROSMAP Brain Pre-frontal Cortex 0.0997 0.0331 8.4e-05 0.103 0.029 0.083 0.095 0.097 3.9e-13 1.0e-04 8.6e-11 3.3e-12 2.0e-12
9 YFS Blood 0.0362 0.0112 5.4e-05 0.028 0.018 0.022 0.021 0.028 1.8e-09 9.7e-07 5.3e-08 1.9e-07 1.3e-09
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0476 0.0237 6.2e-03 0.003 0.008 0.007 NA 0.009 1.4e-01 3.8e-02 4.9e-02 NA 2.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.2 0.4 1.4 -0.1 1.2 1.0 -0.7 -0.2 0.4 0.7 -0.0 0.0 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.8 2.5 0.9 0.8 0.5 -0.1 -0.8 0.7 1.6 0.9 -1.0 -0.6
Depressed Affect (Nagel 2018) 0.4 0.9 4.4 -0.8 -0.3 -0.3 -1.4 -1.2 0.2 0.4 -0.8 2.1 0.3
Depression (Nagel 2018) 0.1 0.2 0.7 0.1 -0.2 -0.6 -0.1 0.1 -0.2 0.8 -0.1 0.8 0.1
Intelligence (Savage-Jansen 2018) 1.0 3.0 7.0 -0.4 -2.5 -2.6 0.3 0.1 -2.6 -1.7 -0.5 -1.2 -2.3
Neuroticism (Nagel 2018) 0.5 1.1 4.8 -0.1 0.4 0.5 -1.9 -1.2 0.9 0.3 -0.2 2.2 0.4
Schizophrenia (2018) 0.4 0.8 2.2 1.2 0.1 -0.2 0.5 -0.9 0.6 1.5 1.2 -1.3 -0.5
Schizophrenia vs Biploar Disorder 0.5 0.7 1.9 0.5 -0.9 -1.4 -0.3 -0.9 -1.3 1.2 0.4 -0.1 0.1
Worry (Nagel 2018) 0.3 0.6 1.5 -0.3 1.2 1.2 -1.2 0.3 0.8 0.5 -0.4 0.6 -0.1
Alzheimer’s Disease (in mother) 1.3 1.6 6.3 1.3 -0.5 -0.5 0.9 1.4 -0.7 0.6 1.2 -2.5 -1.5
Alzheimer’s Disease (in father) 1.7 1.8 5.3 0.2 2.2 2.3 -1.8 0.5 2.1 -0.0 0.1 -0.4 0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 2.4 0.9 0.5 0.5 -0.3 1.3 0.5 0.3 0.8 -1.5 -0.8
Crohns Disease (2017) 0.5 1.1 3.5 1.3 0.6 0.9 -0.8 -0.5 1.9 0.4 1.4 1.1 -0.4
Irritable Bowel Disease (IBD) 0.4 0.8 2.1 1.4 0.6 0.8 0.1 -1.0 1.2 0.9 1.5 0.4 -0.1
Ulcerative Colitis (UC) 0.3 0.6 1.6 1.0 -0.2 -0.2 1.3 -1.3 -0.1 0.6 1.1 -0.2 0.0
Major Depression (MDD) 0.5 0.6 1.6 1.3 -0.1 -0.1 0.3 -0.7 -0.7 -0.9 1.3 0.4 0.7
Reaction Time 0.2 0.3 0.7 0.6 0.7 0.5 0.5 0.9 -0.3 -0.2 0.6 0.1 0.6
Verbal and Numeric Reasoning (VNR) 1.1 2.7 6.9 0.0 -2.3 -2.2 0.7 0.8 -2.6 -2.4 0.0 -1.2 -1.1
Breast Cancer 0.5 1.1 3.0 0.8 -1.4 -1.1 1.0 0.7 -0.4 -1.7 0.9 -0.6 -1.2
Ovarian Cancer 0.1 0.1 0.6 0.1 -0.1 -0.2 0.8 0.5 -0.5 0.1 0.1 -0.1 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 1.6 -0.6 -0.0 0.2 0.5 0.1 1.2 -0.1 -0.7 0.5 -0.9
Bipolar Disorder (2011) 0.2 0.2 0.8 0.9 0.1 0.4 0.3 0.4 0.0 -0.7 0.0 -0.2 0.0
Body Mass Index (BMI) (2010) 1.3 1.8 4.6 0.7 1.9 1.9 -2.1 0.5 2.1 0.8 0.7 0.2 -0.2
Coronary Artery Disease (CAD) 0.3 0.3 2.0 -0.1 -0.4 -0.0 -0.3 -1.4 0.3 -0.9 -0.1 0.5 -0.0
Crohns Disease (2012) 0.1 0.2 0.8 -0.1 0.0 0.2 -0.1 -0.1 0.9 0.4 0.1 0.4 0.8
Mean Putamen Volume 1.9 2.2 7.9 -2.0 0.3 0.0 -0.4 -2.8 0.1 -0.1 -2.1 0.3 2.2
Fasting Glucose 1.4 1.7 7.1 2.5 -0.2 -0.4 1.3 0.5 0.9 -0.2 2.7 0.0 0.2
HbA1C 0.3 0.3 1.4 -1.2 -0.2 -0.1 -0.2 0.2 0.3 -0.5 -1.0 0.4 0.2
HDL Cholesterol 0.8 1.4 2.8 -1.1 1.7 1.5 -1.6 0.5 0.5 1.1 -1.3 0.6 1.1
LDL Cholesterol 0.6 1.0 2.6 -0.3 1.2 1.1 -1.1 0.4 1.6 0.4 -0.3 0.7 -1.6
Lupus 1.2 1.9 8.9 -1.1 0.9 1.1 -1.4 -0.1 3.0 0.5 -1.1 1.1 1.3
Neuroticism (2016) 1.9 2.7 7.7 0.4 1.7 1.7 -2.8 -1.6 2.1 1.0 0.1 2.5 -0.1
Primary Biliary Cirrhosis 0.4 0.5 1.5 -0.3 1.2 1.2 -0.8 -0.2 0.6 0.5 -0.3 0.9 -0.1
Rheumatoid Arthritis 1.0 1.4 5.7 -2.3 0.6 0.8 -0.2 -0.5 0.6 0.1 -2.4 0.4 1.1
Schizophrenia (2014) 0.5 1.1 3.0 0.7 -0.7 -1.1 0.5 -1.7 -0.7 1.0 0.6 -1.4 -1.3
Triglycerides 1.2 2.0 7.4 0.7 -1.6 -1.4 1.4 -1.6 -1.1 -0.8 1.0 -0.8 -2.7
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.8 1.0 -0.2 -0.3 0.6 -1.4 0.1 0.7 1.2 0.7 0.5
Ulcerative Colitis 0.3 0.4 1.0 -0.4 0.6 0.8 0.5 -0.6 0.4 0.5 -0.3 -0.8 -1.0
Blood Eosinophil Count 0.0 0.2 0.6 0.7 -0.1 -0.5 0.5 -0.1 -0.2 -0.2 0.8 -0.6 0.3
Blood Platelet Count 0.1 1.4 4.5 -1.7 -0.8 -0.3 0.3 0.9 0.2 -1.3 -1.8 -2.1 -0.3
Blood Red Count 0.3 3.0 7.2 -0.8 -2.6 -2.7 1.3 -0.7 -2.5 -1.7 -0.7 -1.4 -1.3
Blood White Count 0.6 4.4 10.8 -1.0 -3.3 -3.2 2.3 -2.4 -2.4 -1.9 -1.0 -0.9 0.0
Heel T-Score 0.6 4.4 16.2 -4.0 0.3 0.6 -1.5 -1.5 0.8 0.7 -4.0 1.8 -1.6
BMI 0.6 3.3 11.1 0.8 0.6 0.7 -2.9 -1.8 1.2 0.0 0.8 2.6 3.3
Height 0.7 13.8 27.5 5.1 -2.7 -3.2 3.6 -0.3 -3.1 5.2 5.2 -3.8 -1.6
Waist Hip Ratio (WHR) 0.8 3.7 10.2 0.4 -2.9 -3.2 2.3 -1.8 -2.3 0.7 0.6 -1.0 1.8
Systolic Blood Pressure 0.2 0.9 2.6 -1.5 0.7 0.6 -0.8 -0.4 -0.0 1.6 -1.6 0.2 0.2
Smoking Status 0.3 0.6 1.8 1.3 0.8 0.8 0.7 0.1 0.8 -0.2 1.3 -0.5 0.2
Allergy or Eczema 0.3 0.9 2.7 0.1 -1.2 -1.1 1.4 0.8 -0.2 0.8 0.1 -0.4 -1.6
Cardiovascular Disease 0.5 1.7 11.1 -0.8 -0.0 0.1 -0.3 -1.4 0.6 0.2 -0.8 1.5 3.3
Hypothyroidism (self reported) 0.4 0.8 3.8 0.1 -1.1 -0.8 -0.4 -1.2 -1.1 -1.9 0.0 -0.1 0.0
Respiratory disease 0.2 0.4 1.1 -1.0 -0.4 -0.3 -0.2 -0.4 0.5 -0.2 -1.0 0.8 0.6
Type 2 Diabetes (T2D) (2018) 0.9 1.7 7.6 1.6 0.4 0.0 -0.8 -0.5 0.8 2.8 1.5 1.4 1.0
Lung FEV1/FVC ratio 0.1 0.5 1.7 0.5 -1.1 -1.3 -0.8 -0.1 -0.1 0.1 0.6 0.2 -1.0
Lung FVC 0.3 1.6 5.6 -0.4 2.1 1.7 0.0 -0.5 0.6 2.4 -0.5 -1.0 1.0
Neuroticism 0.7 1.6 6.0 -0.3 1.3 1.7 -2.5 -0.2 1.4 0.3 -0.5 1.7 0.6
Chronotype (morning person) 0.6 1.3 4.5 1.1 0.5 0.6 1.0 1.5 0.5 0.9 1.1 -1.3 -2.1
Hair Pigment 0.0 1.1 4.0 -0.8 -0.6 -0.7 1.0 -2.0 -0.9 0.9 -0.8 -0.8 -1.2
Tanning 0.0 0.5 1.2 -0.9 0.6 0.9 -0.7 1.0 0.3 -0.1 -1.1 -0.5 0.1
Hand grip strength (left) 0.4 1.1 5.7 -1.3 0.5 0.2 0.7 -0.8 -0.8 2.4 -1.2 -0.7 -0.1
Number of treatments/medications taken 1.2 2.1 7.7 -0.1 1.5 1.9 -1.2 1.6 2.8 1.3 -0.1 0.8 1.1
Average weekly spirits intake 0.3 0.4 0.9 -0.8 -0.2 0.1 -0.6 0.6 0.7 -0.9 -0.7 0.5 -0.5
Sensitivity / hurt feelings 0.9 1.6 10.0 0.3 0.5 0.9 -3.2 -0.2 0.9 0.0 0.2 1.8 -0.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.0 1.0 -1.4 -1.4 0.5 -0.5 -0.6 -0.4 0.8 -0.5 -0.5
Hearing difficulty/problems: Yes 0.7 1.0 5.1 -0.7 -0.9 -0.5 -0.6 0.4 -1.4 -2.2 -0.7 0.2 -0.7
Relative age of first facial hair 0.3 0.6 1.6 0.5 1.0 0.6 -0.8 -0.1 0.5 1.2 0.4 1.1 0.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 2.1 1.4 -0.7 -0.5 -0.1 0.0 0.4 -1.5 1.3 0.5 0.7
Ever used hormone-replacement therapy (HRT) 0.9 1.2 3.5 1.2 1.1 1.0 -0.9 1.4 0.5 1.9 1.1 -0.7 -0.3
Ever had hysterectomy (womb removed) 0.4 0.5 3.6 0.1 0.0 -0.0 -0.6 -1.9 -1.0 -0.2 0.1 -0.1 0.3
Systolic blood pressure, automated reading 0.3 0.9 3.1 -1.8 0.4 0.5 -1.0 -0.8 0.3 0.7 -1.8 -0.2 0.8
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 4.1 -1.3 -1.8 -1.8 2.0 -0.9 -1.9 -0.6 -1.3 -1.6 -1.0
Angina 0.7 0.9 3.4 -1.8 0.2 0.2 -0.6 0.5 0.6 1.1 -1.8 0.1 -0.4
Medication for hormone replacement therapy 0.5 0.6 3.2 0.0 -0.6 -0.2 0.1 0.8 -0.5 -1.8 0.0 -1.0 -0.3
Vitamin and mineral supplements 1.4 1.8 5.2 -0.5 -1.6 -2.1 1.6 -0.3 -2.3 -0.5 -0.2 -0.7 1.6
Supplements: Zinc 0.3 0.3 0.9 -0.6 -0.2 0.0 0.5 0.6 0.1 -0.2 -0.8 -0.3 -1.0
Medication: Co-codamol 0.4 0.5 1.1 -0.6 -1.1 -1.0 0.2 -0.6 -0.4 -1.0 -0.7 0.5 0.4
Medication: Metformin 1.6 2.3 10.4 -0.1 0.9 0.5 -0.8 -1.5 0.7 3.2 -0.0 2.3 1.6
Diabetes (father) 0.7 0.9 2.7 -0.5 -1.5 -1.3 1.6 -0.9 -0.8 0.1 -0.3 0.2 0.7
Diabetes (mother) 0.7 0.9 2.9 0.2 0.7 0.8 -0.8 -0.2 0.1 1.1 0.4 1.5 1.7
Severe depression (siblings) 1.6 1.8 5.4 2.1 1.0 0.5 -0.6 0.1 0.6 0.8 2.1 2.3 1.2
Pack years adult smoking proportion 0.8 1.2 3.6 -0.9 1.5 1.6 -1.9 0.1 0.6 0.5 -1.0 0.6 0.6
Impedance of leg (right) 0.4 2.2 4.8 0.7 -0.5 -0.6 1.8 1.8 -1.5 -2.0 0.7 -2.2 -1.6
Leg fat-free mass (left) 0.5 2.5 5.4 2.3 -1.1 -1.3 -0.4 -2.0 -0.8 2.1 2.3 0.6 1.4
Trunk fat percentage 0.5 2.2 6.9 1.6 0.2 0.4 -2.0 -1.0 0.5 -0.3 1.7 1.9 2.6
Hand grip strength (right) 0.4 1.2 3.8 -0.9 0.2 -0.1 1.6 -1.0 -1.6 2.0 -0.8 -0.2 -0.7
Townsend deprivation index at recruitment 0.6 0.8 4.0 1.0 -0.1 -0.3 -0.7 0.1 -0.4 -2.0 0.8 -0.1 1.3
Current tobacco smoking 0.6 1.0 3.9 -0.2 2.0 2.0 -0.3 0.2 1.4 0.4 -0.3 0.2 0.2
Average weekly fortified wine intake 0.4 0.5 1.7 0.1 -0.9 -0.7 0.7 -1.3 -0.0 -1.0 0.1 -0.0 0.3
Maternal smoking around birth 0.9 1.2 3.9 -0.4 -1.8 -2.0 -0.6 -1.7 -0.7 -0.8 -0.3 -0.6 -0.2
Fed-up feelings 0.4 0.7 3.3 -0.1 -0.5 -0.4 -1.4 -0.5 0.6 0.0 -0.1 1.8 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.4 1.2 0.5 0.3 -0.6 0.8 0.8 0.1 1.0 1.0 -0.2
Relative age voice broke 0.4 0.6 3.1 0.3 -0.8 -0.8 -0.3 0.2 -1.1 0.2 0.2 -0.1 -1.8
Taking other prescription medications 0.4 0.6 2.7 0.8 -0.0 0.4 -0.4 0.6 1.6 -0.9 0.8 0.3 0.8
Age when periods started (menarche) 0.6 1.3 4.8 0.6 -1.3 -1.1 0.4 0.8 -1.5 -0.9 0.5 -1.0 -2.2
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 8.6 -1.4 -0.4 -0.4 0.4 -2.9 0.4 0.6 -1.4 1.7 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 5.8 0.3 -2.2 -2.4 0.1 -0.8 -1.6 0.6 0.2 1.4 -2.2
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 3.5 -0.4 1.8 1.9 -0.7 0.6 0.9 1.7 -0.6 0.4 -1.3
Qualifications: CSEs or equivalent 0.2 0.3 1.1 -0.1 0.8 0.8 -0.4 -0.3 0.0 -0.1 -0.1 0.1 -1.1
Serious illness, injury or assault to yourself 0.3 0.4 0.9 -0.9 -0.1 -0.2 -0.5 0.8 0.7 0.8 -0.9 -0.4 -0.4
High blood pressure 0.8 2.1 5.8 -2.0 -0.1 0.1 -1.1 -2.4 0.6 -0.4 -2.1 0.0 2.3
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.1 0.2 -1.5 -1.5 1.2 0.7 -1.0 0.3 0.1 -0.7 -2.0
Multivitamins +/- minerals 0.5 0.6 2.4 0.2 0.8 1.0 -0.7 -0.4 0.8 0.9 -0.1 0.4 -1.6
Stomach or abdominal pain in last month 1.0 1.2 4.6 0.2 -0.4 -0.3 -1.3 -2.1 -0.1 -1.4 -0.1 0.5 -1.7
Supplements: Glucosamine 0.3 0.4 1.5 -0.2 1.0 1.1 -0.2 0.2 0.5 1.2 -0.2 0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.4 0.4 0.2 0.1 -0.6 -0.6 0.4 0.2 0.4 0.6 1.2
Medication: Atenolol 2.6 3.2 5.7 -2.3 1.3 1.4 -1.6 -2.4 1.3 1.6 -2.4 1.4 1.7
Medication: Levothyroxine sodium 0.8 1.4 4.2 -0.0 -1.8 -1.7 0.6 -0.3 -1.8 -2.0 -0.0 -0.3 -0.6
Sitting height 1.5 10.6 37.9 4.6 -1.2 -1.9 3.2 -0.9 -2.4 6.2 4.7 -1.6 -0.6
Chronic bronchitis/emphysema (father) 1.0 1.2 3.4 1.7 -0.6 -0.7 0.1 1.0 -0.5 -0.8 1.8 0.9 1.5
High blood pressure (mother) 1.5 2.1 4.4 -0.9 1.9 1.9 -1.8 0.8 1.3 1.3 -1.0 2.1 0.5
Body mass index (BMI) 0.8 3.4 10.6 0.8 0.6 0.8 -2.7 -1.6 1.1 0.3 0.8 3.2 3.2
Impedance of leg (left) 0.5 2.2 6.0 0.3 -0.3 -0.3 1.9 2.4 -1.2 -1.9 0.4 -2.4 -1.2
Leg predicted mass (left) 0.5 2.5 5.5 2.3 -1.1 -1.3 -0.5 -1.9 -0.8 2.2 2.3 0.6 1.4
Trunk fat mass 0.6 2.7 7.6 2.4 -0.2 -0.0 -1.7 -1.4 0.1 0.5 2.5 1.7 2.8
Waist circumference 0.8 3.0 8.6 1.8 -0.8 -0.9 -1.4 -2.4 -0.0 1.4 1.9 1.7 2.9
Number of incorrect matches in round 0.8 1.4 4.0 2.0 0.7 0.4 0.7 1.0 1.4 0.8 1.9 0.1 -1.0
Past tobacco smoking 0.5 1.0 3.8 -2.0 -0.6 -0.7 -0.3 -0.4 -0.7 -0.4 -2.0 -0.0 0.6
Alcohol usually taken with meals 0.3 0.5 2.2 -0.7 0.3 0.3 -0.2 1.5 0.5 0.9 -0.8 -0.4 -0.2
Nervous feelings 0.3 0.6 2.1 0.3 0.5 1.0 -1.2 1.1 1.5 0.2 0.3 -0.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.8 0.8 0.8 0.7 -0.5 -0.0 0.9 0.9 0.7 -0.3 0.1
Hearing difficulty/problems with background noise 0.4 0.6 1.8 1.4 -0.9 -0.8 -0.5 -0.2 -0.8 -0.8 1.2 0.1 0.3
Hair/balding pattern: Pattern 2 2.1 2.6 8.0 -2.0 -1.2 -0.4 -2.8 -0.8 -0.3 -1.1 -2.1 1.7 -1.8
Had menopause 0.3 0.4 1.4 -0.7 0.3 0.2 0.6 -0.6 -0.7 -0.0 -0.6 -0.2 1.2
Had other major operations 0.5 0.7 2.2 -0.3 0.1 0.5 -0.6 1.4 1.2 -1.5 -0.4 0.4 -0.2
Forced vital capacity (FVC) 0.5 1.7 5.9 1.8 0.2 -0.1 1.9 0.9 -0.1 2.4 1.9 -0.7 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.9 0.1 -1.0 -1.1 -0.6 -0.7 -0.2 1.7 0.0 2.0 -0.9
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.9 0.6 1.0 1.5 -0.2 -0.6 1.7 0.4 0.5 -0.7 -1.3
Qualifications: None of the above 0.5 1.1 3.0 0.3 -1.1 -1.2 1.7 -1.2 -0.7 -0.6 0.4 0.9 1.4
Financial difficulties in last 2 years 0.4 0.5 1.5 1.0 0.5 0.6 -1.2 -0.6 0.5 -0.1 0.9 -0.7 -0.3
Mouth/teeth dental problems 0.3 0.4 1.5 -0.6 -0.8 -0.8 -0.1 0.0 -0.3 -1.2 -0.6 0.3 0.6
Heart attack 1.5 1.9 6.2 -2.4 0.6 0.8 -1.5 -1.2 0.9 1.1 -2.5 -0.0 0.0
Allergy 0.1 0.2 0.4 -0.5 0.5 0.5 -0.5 0.1 0.4 -0.6 -0.4 -0.2 0.6
Pain all over the body in last month 0.8 0.8 1.5 1.1 0.9 0.8 -1.2 0.7 1.1 0.8 0.9 -0.4 -0.9
Diabetes (self-reported) 1.1 1.7 6.2 1.0 0.6 0.2 -0.8 -1.3 0.6 2.5 0.9 1.7 1.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.0 0.8 -0.4 -0.5 0.6 1.7 0.7 1.2 0.9 -0.8 -0.7
Medication: Ramipril 2.5 3.2 12.3 -3.5 0.8 1.2 -1.0 -1.3 1.1 1.2 -3.5 0.2 0.4
Medication: Simvastatin 1.2 1.8 4.3 -0.3 1.8 1.8 -0.6 0.5 1.8 1.9 -0.3 0.3 2.1
Fluid intelligence score 0.2 0.5 1.9 0.3 -0.7 -0.7 -0.3 0.8 -0.9 -0.4 0.3 -1.4 -0.6
Illnesses of siblings 1.6 2.2 7.0 2.1 -1.0 -1.0 1.8 0.4 -0.9 0.3 2.1 -0.8 -2.6
Neuroticism score 0.9 1.8 7.0 0.6 0.9 1.0 -2.7 -0.3 1.2 0.6 0.5 2.1 1.6
Weight 0.6 3.0 8.3 2.8 -0.7 -0.7 -1.0 -1.6 -0.4 1.5 2.9 1.5 2.3
Impedance of arm (right) 0.3 1.5 5.3 -0.5 -0.6 -0.5 1.4 0.5 -0.9 -1.8 -0.4 -2.3 -1.5
Arm fat percentage (right) 0.9 3.6 11.1 0.6 0.9 1.2 -2.8 -2.0 1.3 -0.0 0.7 2.9 3.3
Trunk fat-free mass 0.7 4.1 11.5 3.4 -1.2 -1.5 0.8 -1.6 -1.2 2.9 3.4 -0.3 1.0
Hip circumference 0.5 2.1 5.7 2.1 -0.0 0.0 -1.6 -1.5 0.1 0.1 2.1 1.4 2.4
Time employed in main current job 3.0 3.5 7.5 1.6 2.3 2.5 -1.2 2.5 2.7 1.5 1.5 1.0 0.4
Alcohol intake versus 10 years previously 0.5 0.7 2.9 0.5 -1.7 -1.5 0.3 -0.5 -0.4 -0.6 0.5 0.7 0.1
Father’s age at death 0.5 0.7 2.1 0.7 0.4 0.6 0.3 1.4 0.2 -0.8 0.7 0.8 -1.3
Worrier / anxious feelings 0.2 0.5 1.1 1.0 0.6 0.7 0.4 0.8 0.0 0.5 0.9 -0.2 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 4.0 1.7 -0.1 0.1 -1.2 0.2 1.3 -0.4 1.4 -0.2 -2.0
Falls in the last year 1.1 1.5 4.2 0.5 1.7 1.8 -0.6 2.1 1.1 0.4 0.3 -1.4 -0.6
Hair/balding pattern: Pattern 3 1.1 1.7 5.6 1.1 -0.7 -1.0 2.4 1.5 -0.4 -0.0 1.3 -1.8 -1.1
Number of live births 1.0 1.4 4.4 -1.6 0.0 0.0 1.4 -0.8 -1.0 -0.9 -1.5 -2.1 0.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.8 1.8 -0.3 -0.8 1.9 0.8 -0.3 2.0 1.9 -0.9 -0.4
Pulse rate 0.8 1.3 5.1 -0.6 -1.3 -1.0 -0.3 -1.8 -0.5 -2.3 -0.6 -0.8 0.7
Happiness 0.7 0.8 4.1 0.6 0.1 0.1 0.3 -1.0 -0.2 0.8 0.6 -2.0 -1.2
Noisy workplace 0.4 0.5 2.4 -0.2 -0.2 -0.4 0.7 -1.5 -0.3 -0.1 -0.0 0.1 1.2
Qualifications: A levels/AS levels or equivalent 0.6 1.3 5.9 0.0 -0.2 -0.1 -0.5 0.8 0.2 0.7 -0.1 -2.4 -2.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.6 0.7 -1.0 -0.8 0.9 -1.6 -0.5 -0.2 0.8 -0.9 -0.9
Mouth/teeth dental problems: Dentures 0.3 0.5 2.4 -0.6 -0.6 -0.5 1.1 -1.6 -0.3 0.1 -0.5 -0.4 -0.1
Asthma 0.1 0.3 0.9 -0.9 -0.1 -0.1 0.0 -0.9 -0.2 -0.2 -0.8 -0.4 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 8.9 3.0 0.0 0.1 -0.7 0.7 0.3 0.3 2.8 1.3 -2.2
Medication: Cholesterol lowering 0.8 1.3 4.6 -0.9 0.6 0.7 -0.3 0.1 1.3 1.8 -0.9 0.8 2.1
Depression (self-reported) 0.9 1.1 2.6 1.4 0.3 0.4 -1.6 1.2 1.5 0.7 1.2 0.5 -0.5
Medication: Lansoprazole 2.7 3.1 6.2 1.4 2.5 2.5 -2.4 0.9 2.1 0.8 1.3 1.5 0.8
Prospective memory result 0.5 0.7 1.6 -1.3 -0.6 -0.3 0.0 -0.1 0.3 -1.3 -1.2 0.8 -0.9
Lung cancer (father) 1.0 1.2 2.7 1.0 -1.5 -1.6 1.4 1.4 -0.7 0.3 1.0 -0.5 -0.4
Illnesses of mother 2.2 2.8 7.4 -0.7 -2.1 -2.0 1.7 -1.2 -1.3 -2.2 -0.7 -2.7 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 6.0 2.5 -0.8 -1.4 1.6 1.0 -1.0 2.4 2.4 -1.1 -0.8
Pulse wave Arterial Stiffness index 0.5 0.6 1.7 -0.3 1.2 1.3 -0.3 -0.6 -0.0 -0.6 -0.3 -0.7 -1.3
Impedance of arm (left) 0.3 1.5 4.2 -0.4 -0.5 -0.4 1.3 1.0 -0.6 -1.9 -0.4 -2.1 -1.8
Arm fat mass (right) 0.7 2.9 9.1 1.5 0.1 0.2 -1.9 -2.0 0.4 0.6 1.5 2.6 3.0
Trunk predicted mass 0.7 4.0 10.9 3.3 -1.3 -1.5 0.7 -1.7 -1.3 2.8 3.3 -0.2 1.1
Standing height 1.0 10.3 21.4 4.5 -2.8 -3.2 3.5 -0.2 -3.1 2.7 4.6 -3.4 -1.5
Length of working week for main job 0.2 0.3 1.6 0.3 -0.2 -0.5 1.3 -0.3 -0.0 0.5 0.3 -0.2 0.4
Exposure to tobacco smoke at home 0.5 0.6 1.4 1.0 0.7 0.5 0.5 1.2 -0.2 1.1 1.0 0.4 0.7
Breastfed as a baby 1.0 1.3 3.9 2.0 0.3 0.1 0.9 1.0 0.1 1.3 2.0 -0.7 1.1
Tense / ‘highly strung’ 0.3 0.6 2.5 -0.8 0.3 0.5 -1.6 -1.0 0.7 -0.1 -0.9 0.3 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.0 1.7 1.5 1.5 -0.5 2.0 2.0 1.2 1.7 0.0 -0.0
Hair/balding pattern: Pattern 4 0.2 0.5 3.2 0.1 0.5 0.1 -0.1 1.8 -0.5 -0.2 0.0 -0.2 1.0
Birth weight of first child 0.2 0.3 1.0 1.0 -0.1 0.1 -0.9 0.2 -0.2 -0.1 1.0 0.2 0.0
Peak expiratory flow (PEF) 0.3 0.6 2.0 0.6 0.6 0.1 1.4 -0.6 -0.2 1.0 0.7 -1.3 -0.5
Pulse wave reflection index 1.0 1.2 7.7 -0.3 1.3 1.4 -0.5 0.4 0.2 0.2 -0.4 -0.2 -2.8
Ever highly irritable/argumentative for 2 days 1.5 1.8 7.8 1.3 -0.4 -0.0 -0.4 2.8 0.5 -0.6 1.5 2.2 -0.2
Loud music exposure frequency 0.7 0.8 1.4 0.9 1.1 1.2 -0.4 -0.5 1.2 1.1 0.9 -0.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 3.1 0.7 -0.2 0.0 -1.8 1.0 0.6 0.3 0.6 -0.5 -1.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.9 -0.1 0.5 0.4 -0.6 1.4 0.1 0.3 -0.1 0.3 1.2
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.7 0.6 0.7 0.8 -0.3 0.4 -0.9 -0.6 0.2 0.3
Medication: Paracetamol 0.8 1.3 2.2 1.5 1.3 1.5 -1.3 0.1 1.3 1.1 1.3 0.5 -0.3
Headache pain in last month 0.4 0.6 1.4 1.2 -0.7 -0.8 0.5 0.8 -0.6 -0.8 1.0 -0.8 -0.5
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 6.0 1.5 -1.9 -2.1 2.0 0.1 -2.4 -1.9 1.4 -0.8 -2.4
Glaucoma (self-reported) 0.7 0.8 2.8 0.2 -0.9 -0.8 -0.0 -1.7 0.9 -0.3 0.3 0.8 1.4
Gout (self-reported) 0.6 0.8 1.9 1.1 0.5 0.1 1.1 0.6 -0.4 1.0 1.1 -1.4 -0.6
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 6.2 0.2 -1.9 -1.7 0.7 -1.6 -2.0 -2.5 0.2 -0.6 -0.9
Medication: Amlodipine 0.9 1.2 3.1 -0.6 1.4 1.5 -0.5 -1.0 1.8 1.7 -0.5 0.3 -0.5
Medication: Ventolin 100micrograms inhaler 0.9 1.1 3.4 -1.4 0.5 0.5 -1.8 -0.6 0.2 0.3 -1.4 0.4 1.7
Birth weight 1.0 2.1 5.6 1.7 1.3 1.2 -0.2 1.1 0.9 2.4 1.8 1.0 1.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.6 -0.6 0.9 1.2 -1.6 -0.9 0.9 -0.2 -0.6 0.9 -0.1
High blood pressure (siblings) 0.9 1.3 3.7 -1.9 -0.1 -0.1 -0.6 -1.4 -0.9 -0.4 -1.9 -1.0 0.8
Forced vital capacity (FVC), Best measure 0.8 2.8 8.2 2.6 -0.0 -0.6 1.6 1.0 -0.6 2.9 2.6 -1.2 -0.5
Body fat percentage 0.7 2.6 9.4 1.3 0.4 0.6 -2.3 -1.2 0.6 -0.4 1.4 2.3 3.1
Leg fat percentage (right) 0.7 2.5 8.4 1.2 0.7 0.8 -2.1 -1.1 0.8 -0.6 1.3 2.3 2.9
Arm fat-free mass (right) 0.6 3.3 9.7 3.1 -1.3 -1.5 0.2 -0.9 -1.1 2.3 3.1 0.3 1.4
Exposure to tobacco smoke outside home 1.0 1.4 5.2 1.1 -0.9 -0.5 0.0 0.9 -0.4 -2.3 1.0 -1.1 -1.7
Comparative body size at age 10 2.0 5.5 14.7 -0.7 3.2 2.8 -2.5 0.1 1.7 3.8 -0.7 2.8 2.2
Number of full brothers 0.7 0.9 2.9 0.8 -0.7 -0.6 0.8 -0.4 -1.7 -1.6 0.7 -0.4 -0.4
Worry too long after embarrassment 1.1 1.9 4.7 0.9 1.5 1.4 -2.2 -0.3 0.8 1.7 0.9 1.3 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.0 1.7 1.1 1.3 -0.8 1.4 1.3 1.6 1.5 0.3 -1.6
Wheeze or whistling in the chest in last year 0.2 0.4 1.8 -0.4 0.5 0.4 -0.6 -0.7 0.3 1.4 -0.6 -0.1 -0.6
Number of children fathered 0.4 0.4 1.1 -1.0 0.4 0.5 0.2 -0.6 0.4 0.5 -1.1 0.5 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.1 -0.4 -0.8 -1.1 0.2 -0.5 -0.4 1.2 -0.3 -1.4 -0.2
Age at first live birth 0.7 1.2 4.8 -0.5 -0.8 -0.9 -0.2 0.6 -1.4 -0.2 -0.6 -1.8 -2.2
Pulse wave peak to peak time 0.7 0.8 2.7 0.5 -1.5 -1.6 0.5 0.6 -0.3 0.8 0.5 0.4 1.1
Health satisfaction 0.7 0.9 3.4 1.8 -0.6 -0.4 0.2 0.1 0.1 -0.8 1.8 -0.4 -1.0
Shortness of breath walking on level ground 1.3 1.5 6.5 -1.9 0.3 0.4 -0.1 -2.5 -0.8 -0.7 -1.9 0.5 -0.1
Qualifications: College or University degree 0.5 1.6 4.3 2.0 0.3 -0.0 0.6 1.9 -0.1 0.4 2.1 -1.8 -0.8
Eye problems/disorders: None of the above 0.3 0.3 1.1 0.7 -0.3 -0.5 0.3 0.1 -0.7 0.0 0.8 1.1 0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 0.5 0.8 0.5 0.2 1.0 0.8 1.0 0.4 -0.6 1.4
Emphysema/chronic bronchitis 0.7 0.7 2.2 1.5 0.4 0.4 0.1 -0.0 0.9 0.5 1.5 -1.2 0.5
Medication for pain relief, constipation, heartburn 0.7 1.3 3.6 -0.7 -1.3 -1.6 1.3 -0.6 -1.9 -0.9 -0.5 -1.1 0.2
Neck or shoulder pain in last month 0.5 0.7 2.2 0.8 -0.6 -0.5 -1.4 -0.9 -0.0 0.3 0.7 1.5 0.0
Medication: Blood pressure 1.7 3.1 5.3 -2.2 1.3 1.7 -2.3 -1.2 1.8 1.0 -2.2 0.4 2.2
Angina (self-reported) 0.6 0.8 3.0 -1.7 0.3 0.2 -0.4 0.3 0.5 1.3 -1.7 0.1 -0.2
Migraine (self-reported) 1.5 1.9 7.6 -2.1 0.2 0.1 0.0 -2.7 -0.6 0.7 -2.2 -0.3 1.0
Medication: Ibuprofen 1.7 2.1 6.1 2.3 1.0 1.2 -0.3 1.1 1.0 0.5 2.1 0.5 -2.5
Medication: Allopurinol 1.6 2.1 7.1 1.8 0.3 -0.2 1.7 0.4 -0.4 1.6 1.8 -2.7 -1.3
Medication: Omeprazole 0.5 0.6 2.1 -0.7 0.7 1.2 -0.5 0.5 1.5 -0.6 -0.8 -0.3 0.3
Medication: Seretide 50 evohaler 0.5 0.6 1.8 -0.9 -1.0 -0.9 -0.0 -0.2 0.0 -1.3 -0.8 -1.0 -0.3
Mean time to correctly identify matches 0.2 0.5 1.3 0.7 0.9 0.8 0.1 1.1 0.5 0.3 0.6 0.2 0.7
Heart disease (mother) 1.2 1.5 5.2 0.3 -0.2 -0.4 -1.9 2.2 -0.0 0.9 0.3 2.3 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 3.2 -0.9 -1.1 -1.3 0.2 0.8 -0.7 -0.5 -0.9 0.0 -1.8
Whole body fat mass 0.7 2.8 8.8 1.9 0.0 0.1 -2.0 -1.6 0.2 0.4 1.9 2.3 3.0
Leg fat mass (right) 0.8 2.9 9.6 1.9 -0.0 0.1 -1.8 -1.7 0.4 0.2 1.9 2.5 3.1
Arm predicted mass (right) 0.8 4.1 12.5 3.5 -1.3 -1.6 0.3 -1.1 -1.1 2.6 3.5 0.6 1.3
Pulse rate, automated reading 0.3 0.9 3.6 0.9 -0.3 0.4 -1.2 -1.0 0.8 -1.9 0.9 0.2 0.8
Alcohol intake frequency. 0.3 0.8 2.0 -0.9 -0.2 0.1 0.5 0.9 1.2 -1.2 -0.9 0.1 1.4
Comparative height size at age 10 0.6 3.4 6.8 1.4 -2.6 -2.6 2.5 -0.5 -2.0 1.2 1.6 -2.1 -0.4
Number of full sisters 1.5 1.9 4.9 -1.3 -0.9 -1.1 1.7 -0.6 -1.7 -2.2 -1.2 -1.0 1.0
Suffer from ‘nerves’ 0.3 0.5 2.6 -0.2 0.2 0.1 -1.6 -0.7 0.7 0.4 -0.1 0.8 0.7
Overall health rating 0.6 1.3 5.8 2.4 -0.5 -0.5 -0.4 0.1 0.8 -0.6 2.3 0.1 -0.2
Chest pain or discomfort 0.7 1.0 3.1 -1.2 0.4 0.2 -1.8 -0.5 0.7 1.1 -1.3 -1.0 -0.5
Had major operations 0.1 0.2 0.7 0.4 -0.2 -0.0 0.3 0.1 0.5 -0.2 0.3 0.9 -0.4
Age at last live birth 1.0 1.5 6.2 0.1 0.8 0.6 -0.0 1.4 0.1 1.1 -0.1 -2.5 -2.1
Family relationship satisfaction 0.7 0.9 5.7 -0.2 0.5 -0.1 -0.5 -1.0 0.4 2.4 -0.2 -0.7 1.0
Leg pain on walking 1.0 1.3 2.9 0.6 1.5 1.5 -0.9 1.1 1.7 0.7 0.7 1.0 1.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.6 -0.1 0.8 0.8 0.5 0.6 -0.0 -0.8 -0.1 -0.7 0.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.9 0.7 -0.7 -0.9 1.2 -0.4 -1.4 -1.0 0.6 0.5 -0.0
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 9.5 -1.7 0.3 0.4 -0.6 0.3 -0.3 -0.3 -1.6 1.4 3.1
Medication: Aspirin 1.2 1.6 5.8 -1.0 0.9 1.1 -0.8 0.5 2.4 2.1 -1.0 0.7 -0.1
Supplements: Vitamin C 0.4 0.5 0.9 -0.2 0.6 1.0 -0.9 1.0 0.9 -0.4 -0.3 0.4 -0.6
Knee pain experienced in last month 0.5 0.8 2.0 1.3 -0.4 -0.3 -0.8 0.5 0.6 -0.1 1.4 1.4 0.7
Hypertension (Self-reported) 0.8 2.2 5.0 -2.2 0.2 0.4 -1.4 -2.0 1.0 -0.2 -2.2 0.0 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 3.1 1.3 -0.5 -0.3 0.2 1.7 0.4 -1.8 1.4 -0.6 0.3
Illnesses of father: Heart disease 2.0 2.8 6.8 0.3 2.1 1.9 -2.6 1.7 2.0 2.3 0.2 0.2 0.7
Illnesses of siblings: Diabetes 0.8 1.0 6.0 -1.0 0.4 0.4 -0.8 -0.4 0.9 -0.1 -0.8 0.4 2.5
Smoking status: Previous 0.5 0.8 3.2 1.7 -0.3 -0.1 1.0 0.3 0.2 0.3 1.8 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.6 7.9 2.8 -1.9 -2.1 1.9 1.6 -1.5 0.8 2.8 -1.3 -1.5
Whole body fat-free mass 0.6 3.4 8.9 3.0 -1.3 -1.5 0.3 -1.7 -1.1 2.6 3.0 0.2 1.3
Leg fat-free mass (right) 0.4 2.2 4.9 2.2 -1.1 -1.2 -0.1 -1.5 -0.6 2.2 2.2 0.4 1.3
Arm fat percentage (left) 0.8 3.1 9.4 0.6 0.7 0.9 -2.6 -1.9 1.0 -0.2 0.7 2.8 3.1
Average weekly red wine intake 0.9 1.4 9.2 -0.4 0.7 0.3 0.4 -1.2 -0.1 1.3 -0.4 -0.3 3.0
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.8 -1.7 -1.3 -1.2 1.0 -0.1 -0.9 -0.6 -1.7 0.7 -1.3
Mood swings 0.7 1.3 3.6 0.3 -1.9 -1.9 -0.1 -0.4 -1.4 -1.2 0.3 1.6 -0.3
Loneliness, isolation 0.2 0.3 0.9 -0.0 0.3 0.2 -0.8 -0.9 1.0 0.2 -0.1 0.2 -0.1
Long-standing illness, disability or infirmity 0.4 0.7 1.3 1.1 -1.1 -0.9 -0.9 -0.0 -0.4 -0.7 1.1 0.3 0.8
Ever had bowel cancer screening 0.8 0.9 2.4 0.3 1.2 1.6 0.2 0.5 1.5 1.0 0.3 -0.4 1.2
Diabetes diagnosed by doctor 0.8 1.3 7.5 0.7 0.1 -0.3 -0.4 -1.1 -0.0 2.7 0.7 1.1 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.8 -0.2 -0.6 -0.7 -0.4 1.0 0.2 -1.4 -0.1 0.4 0.8
Friendships satisfaction 0.4 0.5 3.4 0.6 0.7 0.3 -0.5 0.4 0.4 1.8 0.6 0.1 0.4
Qualifications: nursing, teaching 0.2 0.2 1.2 -0.3 -0.6 -0.6 -0.3 -0.1 -0.1 -1.1 -0.3 0.3 -0.1
Commuting to job workplace: Walk 1.1 1.2 2.3 1.5 1.2 1.2 -1.5 0.6 0.5 0.5 1.4 1.2 0.5
Eye problems/disorders: Cataract 1.1 1.2 4.0 -0.9 1.2 1.1 -2.0 1.6 0.5 0.4 -1.0 -0.7 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.1 0.8 1.0 1.0 -0.9 0.7 0.5 -0.3 0.7 0.9 -0.0
Medication for cholesterol 0.1 0.2 0.6 0.7 -0.0 -0.1 -0.2 0.6 -0.3 0.1 0.8 -0.2 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.4 1.0 0.5 0.5 -0.3 1.1 1.2 0.2 1.0 -0.0 0.9
Back pain experienced in last month 0.9 1.4 2.9 -1.1 -1.4 -0.9 -1.0 -0.3 -0.2 -1.7 -1.0 1.4 -1.7
Mineral and other dietary supplements 0.6 0.8 3.7 0.1 -0.6 -0.6 -0.8 -0.3 -0.2 -1.9 0.1 0.3 1.6
Breast cancer (self-reported) 0.4 0.5 1.1 -1.1 -0.4 -0.6 -0.1 0.4 0.4 1.0 -1.0 0.8 0.8
Asthma (self-reported) 0.1 0.3 0.5 -0.7 -0.5 -0.5 0.5 -0.5 -0.5 -0.3 -0.6 -0.7 -0.1
Osteoporosis (self-reported) 0.6 0.8 1.9 1.4 -0.1 0.3 -0.3 0.7 1.4 -1.0 1.4 -0.0 0.7
Osteoarthritis (self-reported) 0.2 0.3 0.8 -0.9 -0.2 -0.2 -0.1 -0.7 -0.2 -0.3 -0.9 -0.6 0.1
Medication: Aspirin 1.0 1.4 5.2 -0.8 0.7 0.9 -0.8 0.0 2.3 2.2 -0.9 0.5 -0.1
Medication: Gliclazide 1.1 1.2 4.3 1.0 0.3 -0.3 -0.9 0.1 0.3 1.5 1.1 2.1 1.5
Illnesses of father: None of the above (group 1) 1.1 1.4 3.5 -1.1 -1.2 -1.2 1.9 -1.3 -1.4 0.1 -0.9 -1.1 0.0
Smoking status: Current 0.6 1.0 3.9 -0.1 2.0 1.9 -0.2 0.4 1.4 0.8 -0.2 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 4.1 1.1 1.2 0.8 -0.4 1.6 0.6 2.0 1.1 -0.2 0.5
Whole body water mass 0.6 3.5 9.6 3.1 -1.1 -1.4 0.2 -1.7 -1.0 2.6 3.1 0.4 1.4
Leg predicted mass (right) 0.4 2.2 4.8 2.1 -1.1 -1.3 -0.1 -1.6 -0.6 2.2 2.1 0.4 1.3
Arm fat mass (left) 0.8 3.3 9.2 1.7 0.2 0.4 -2.3 -2.1 0.6 0.6 1.8 2.8 3.0
Number of self-reported non-cancer illnesses 0.4 0.7 3.5 -0.1 0.0 0.4 -0.4 -0.2 1.5 -0.6 -0.1 0.7 1.9
Average weekly champagne plus white wine intake 0.7 1.0 3.8 0.7 -1.0 -0.9 0.5 2.0 -0.1 0.4 0.7 -0.7 -1.5
Miserableness 1.0 1.7 8.2 1.4 0.1 0.5 -2.9 -0.7 1.4 -0.2 1.4 1.4 0.4
Guilty feelings 1.3 2.0 2.8 1.6 1.0 0.8 -1.7 -1.3 1.2 1.5 1.5 1.6 1.6
Wears glasses or contact lenses 0.1 0.2 1.1 -0.1 0.2 0.4 0.4 1.1 0.2 -0.2 -0.2 -0.2 0.2
Ever taken oral contraceptive pill 0.2 0.3 1.4 -0.4 0.4 0.4 -0.2 1.2 0.1 0.8 -0.3 -0.2 -0.0
Hearing aid user 1.2 1.4 5.6 0.6 -2.4 -2.1 1.0 0.1 -0.8 -0.9 0.7 0.5 0.6
Mother’s age at death 0.7 0.8 3.7 -0.2 -1.0 -0.6 1.0 0.3 -0.7 -1.1 -0.4 -0.3 -1.9
Financial situation satisfaction 1.0 1.2 3.8 -0.4 1.9 1.8 -0.7 -1.0 1.2 1.0 -0.4 0.3 0.8
Tinnitus: Yes, now most or all of the time 1.7 2.0 4.7 0.4 1.6 1.4 -2.0 1.6 1.1 0.4 0.4 2.2 1.6
Commuting to job workplace: Public transport 0.5 0.6 2.3 0.1 -0.5 -0.5 -1.0 -0.6 -1.2 0.1 0.1 -1.5 -0.8
Eye problems/disorders: Glaucoma 0.6 0.7 2.5 1.1 -0.6 -0.4 0.3 -1.6 1.0 0.1 1.1 -0.1 -0.3
Medication: Blood pressure 0.6 1.1 5.3 -1.2 -1.0 -1.0 0.4 -2.3 -0.6 -0.5 -1.2 0.3 -0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.1 -0.4 -1.2 -1.1 1.0 -0.4 0.4 -1.0 -0.5 1.4 1.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.9 0.3 -0.2 0.2 0.8 0.3 0.2 0.8 0.2 0.7 -1.4
High cholesterol (Self-reported) 0.6 1.1 3.0 -0.5 1.0 1.2 -1.0 0.1 1.1 0.7 -0.5 1.4 1.7
Medication: Bendroflumethiazide 0.6 0.8 3.8 0.1 -1.0 -1.0 -0.1 -2.0 -0.9 -0.7 0.1 1.0 0.2
Medication: Paracetamol 0.8 1.2 2.3 1.5 1.1 1.3 -0.9 0.2 1.5 1.0 1.5 0.7 -0.2
Medication: Lisinopril 2.5 3.2 8.6 -0.7 2.0 1.7 -2.9 -0.4 1.2 1.6 -0.6 2.1 2.7
Medication: Atorvastatin 0.4 0.5 1.5 -1.1 -0.4 -0.2 -0.4 -1.1 0.6 0.4 -1.2 0.7 -0.0
Illnesses of father: High blood pressure 0.4 0.5 2.2 -0.1 -0.3 -0.2 -0.4 -1.2 0.4 -1.0 -0.3 1.5 0.5
Alcohol drinker status: Never 0.4 0.5 1.1 -0.0 1.0 1.0 0.5 -0.2 1.0 -0.8 -0.1 0.5 0.6
Ever smoked 0.2 0.4 1.0 0.9 -0.1 -0.1 0.6 -1.0 -0.6 -0.8 0.9 -0.1 -0.2
Basal metabolic rate 0.6 3.3 9.4 3.0 -1.1 -1.3 0.0 -1.6 -0.9 2.3 3.1 0.5 1.6
Leg fat percentage (left) 0.6 2.4 9.9 1.2 0.6 0.8 -1.9 -0.7 0.8 -0.5 1.3 2.1 3.2
Arm fat-free mass (left) 0.8 3.8 10.9 3.2 -1.3 -1.5 0.1 -1.6 -1.1 2.4 3.3 0.6 1.7
Number of operations (self-reported) 0.4 0.5 2.4 -0.0 0.2 0.6 -0.6 0.0 1.0 -1.1 -0.1 1.6 -0.3
Average weekly beer plus cider intake 2.7 3.9 10.4 0.0 -3.2 -2.8 1.2 -2.3 -2.2 -2.6 0.0 0.5 -1.5
Irritability 0.6 1.0 2.5 1.6 -1.2 -1.0 -0.1 0.2 -0.4 -1.5 1.5 0.3 -0.1
Risk taking 0.4 0.6 2.8 0.1 -0.3 0.0 -1.2 -0.7 0.3 0.2 0.1 0.9 -1.7
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.2 -0.3 0.7 1.1 -0.5 1.1 1.8 -0.7 -0.3 1.2 0.3
Fractured/broken bones in last 5 years 2.1 2.8 6.8 -0.3 1.2 1.4 -2.0 2.6 2.2 0.9 -0.3 2.2 1.7
Age started oral contraceptive pill 0.4 0.5 2.5 0.4 0.2 0.1 -1.0 0.5 0.7 1.6 0.4 -0.0 -0.3
Diastolic blood pressure, automated reading 0.3 0.9 2.7 -1.1 0.5 0.8 -1.0 -0.7 0.3 -1.7 -1.2 0.1 1.2
Ever depressed for a whole week 0.7 0.9 1.9 -1.3 0.8 1.3 -0.3 -0.7 1.1 -0.5 -1.4 -0.8 -0.7
Unable to work because of sickness or disability 1.3 1.6 6.3 2.5 0.0 0.0 -0.6 1.6 0.4 -0.9 2.5 -0.2 0.1
Commuting to job workplace: Cycle 0.4 0.5 2.0 0.4 0.0 0.1 -1.2 0.8 -0.1 0.2 0.2 -0.9 -1.4
Myopia 1.1 1.6 4.5 1.5 -1.5 -1.3 1.5 -0.5 -0.2 -2.1 1.5 0.4 0.0
Vascular/heart problems diagnosed by doctor 0.8 2.1 5.7 2.4 0.1 -0.2 0.8 2.1 -0.6 -0.1 2.4 0.3 -2.0
Cholesterol lowering medication 0.6 0.9 2.2 -0.2 1.3 1.3 -0.9 -0.4 1.5 1.4 -0.3 0.8 0.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 3.9 -1.0 1.5 2.0 -0.8 1.1 1.7 -0.3 -1.1 0.1 0.6
Pain experienced in last month 0.8 1.4 5.7 0.2 1.1 0.7 1.3 1.0 0.3 2.4 0.4 -1.4 1.2
Supplements: Calcium 1.3 1.4 3.6 -1.8 0.1 0.2 -1.2 -1.6 0.4 0.8 -1.9 1.1 1.2
Basal cell carcinoma (self-reported) 0.7 0.9 1.5 0.8 -1.2 -1.1 1.1 0.1 -0.8 -1.2 0.9 1.2 -0.1
Heart attack/myocardial infarction (self-reported) 1.3 1.7 5.3 -2.3 0.7 0.8 -1.3 -1.2 1.0 1.1 -2.3 0.1 0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.3 -0.7 0.9 1.1 0.6 -0.2 0.9 -1.1 -0.7 0.4 0.3
Heart disease (siblings) 1.7 2.1 5.3 -1.1 1.4 1.1 -1.8 0.2 1.2 1.4 -1.0 1.9 2.3
Alcohol drinker status: Previous 0.3 0.4 1.1 -0.0 -0.6 -0.5 0.5 1.0 1.0 0.4 0.1 0.4 0.6
Pack years of smoking 0.8 1.1 2.3 -0.9 1.5 1.5 -1.5 -0.2 0.7 0.5 -0.9 1.1 0.9
Impedance of whole body 0.4 2.0 6.1 0.0 -0.5 -0.5 1.7 1.7 -1.0 -1.9 0.1 -2.5 -1.7
Leg fat mass (left) 0.7 2.9 10.6 2.0 -0.1 -0.1 -1.6 -1.5 0.3 0.1 2.0 2.3 3.2
Arm predicted mass (left) 0.8 3.9 12.0 3.4 -0.9 -1.1 -0.1 -1.3 -0.8 2.7 3.5 0.6 1.8