Hub : Genes

SH3BGRL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1140	0.0420	7.2e-04	0.182	0.009	0.167	0.173	0.181	1.4e-21	2.6e-02	7.5e-20	1.3e-20	1.7e-21
2	GTEx	Adipose Subcutaneous	0.1710	0.0550	1.3e-04	0.142	NA	0.118	NA	0.140	1.0e-11	NA	6.6e-10	NA	1.6e-11
3	GTEx	Adipose Visceral Omentum	0.1570	0.0580	3.4e-03	0.104	NA	0.068	NA	0.103	5.0e-06	NA	2.1e-04	NA	5.6e-06
4	GTEx	Colon Transverse	0.1130	0.0430	3.9e-03	0.012	NA	0.050	NA	0.042	8.1e-02	NA	2.1e-03	NA	4.2e-03
5	GTEx	Esophagus Mucosa	0.1340	0.0470	2.6e-03	0.030	NA	0.033	NA	0.054	4.4e-03	NA	2.9e-03	NA	1.8e-04
6	GTEx	Lung	0.2127	0.0582	2.4e-05	0.099	NA	0.080	NA	0.096	5.1e-08	NA	1.0e-06	NA	8.1e-08
7	GTEx	Nerve Tibial	0.1809	0.0610	2.4e-04	0.018	NA	0.034	NA	0.036	1.7e-02	NA	1.8e-03	NA	1.4e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.0997	0.0331	8.4e-05	0.103	0.029	0.083	0.095	0.097	3.9e-13	1.0e-04	8.6e-11	3.3e-12	2.0e-12
9	YFS	Blood	0.0362	0.0112	5.4e-05	0.028	0.018	0.022	0.021	0.028	1.8e-09	9.7e-07	5.3e-08	1.9e-07	1.3e-09
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0476	0.0237	6.2e-03	0.003	0.008	0.007	NA	0.009	1.4e-01	3.8e-02	4.9e-02	NA	2.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.2	0.4	1.4	-0.1	1.2	1.0	-0.7	-0.2	0.4	0.7	-0.0	0.0	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.5	0.9	0.8	0.5	-0.1	-0.8	0.7	1.6	0.9	-1.0	-0.6
Depressed Affect (Nagel 2018)	0.4	0.9	4.4	-0.8	-0.3	-0.3	-1.4	-1.2	0.2	0.4	-0.8	2.1	0.3
Depression (Nagel 2018)	0.1	0.2	0.7	0.1	-0.2	-0.6	-0.1	0.1	-0.2	0.8	-0.1	0.8	0.1
Intelligence (Savage-Jansen 2018)	1.0	3.0	7.0	-0.4	-2.5	-2.6	0.3	0.1	-2.6	-1.7	-0.5	-1.2	-2.3
Neuroticism (Nagel 2018)	0.5	1.1	4.8	-0.1	0.4	0.5	-1.9	-1.2	0.9	0.3	-0.2	2.2	0.4
Schizophrenia (2018)	0.4	0.8	2.2	1.2	0.1	-0.2	0.5	-0.9	0.6	1.5	1.2	-1.3	-0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	0.5	-0.9	-1.4	-0.3	-0.9	-1.3	1.2	0.4	-0.1	0.1
Worry (Nagel 2018)	0.3	0.6	1.5	-0.3	1.2	1.2	-1.2	0.3	0.8	0.5	-0.4	0.6	-0.1
Alzheimer’s Disease (in mother)	1.3	1.6	6.3	1.3	-0.5	-0.5	0.9	1.4	-0.7	0.6	1.2	-2.5	-1.5
Alzheimer’s Disease (in father)	1.7	1.8	5.3	0.2	2.2	2.3	-1.8	0.5	2.1	-0.0	0.1	-0.4	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	0.9	0.5	0.5	-0.3	1.3	0.5	0.3	0.8	-1.5	-0.8
Crohns Disease (2017)	0.5	1.1	3.5	1.3	0.6	0.9	-0.8	-0.5	1.9	0.4	1.4	1.1	-0.4
Irritable Bowel Disease (IBD)	0.4	0.8	2.1	1.4	0.6	0.8	0.1	-1.0	1.2	0.9	1.5	0.4	-0.1
Ulcerative Colitis (UC)	0.3	0.6	1.6	1.0	-0.2	-0.2	1.3	-1.3	-0.1	0.6	1.1	-0.2	0.0
Major Depression (MDD)	0.5	0.6	1.6	1.3	-0.1	-0.1	0.3	-0.7	-0.7	-0.9	1.3	0.4	0.7
Reaction Time	0.2	0.3	0.7	0.6	0.7	0.5	0.5	0.9	-0.3	-0.2	0.6	0.1	0.6
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.9	0.0	-2.3	-2.2	0.7	0.8	-2.6	-2.4	0.0	-1.2	-1.1
Breast Cancer	0.5	1.1	3.0	0.8	-1.4	-1.1	1.0	0.7	-0.4	-1.7	0.9	-0.6	-1.2
Ovarian Cancer	0.1	0.1	0.6	0.1	-0.1	-0.2	0.8	0.5	-0.5	0.1	0.1	-0.1	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	1.6	-0.6	-0.0	0.2	0.5	0.1	1.2	-0.1	-0.7	0.5	-0.9
Bipolar Disorder (2011)	0.2	0.2	0.8	0.9	0.1	0.4	0.3	0.4	0.0	-0.7	0.0	-0.2	0.0
Body Mass Index (BMI) (2010)	1.3	1.8	4.6	0.7	1.9	1.9	-2.1	0.5	2.1	0.8	0.7	0.2	-0.2
Coronary Artery Disease (CAD)	0.3	0.3	2.0	-0.1	-0.4	-0.0	-0.3	-1.4	0.3	-0.9	-0.1	0.5	-0.0
Crohns Disease (2012)	0.1	0.2	0.8	-0.1	0.0	0.2	-0.1	-0.1	0.9	0.4	0.1	0.4	0.8
Mean Putamen Volume	1.9	2.2	7.9	-2.0	0.3	0.0	-0.4	-2.8	0.1	-0.1	-2.1	0.3	2.2
Fasting Glucose	1.4	1.7	7.1	2.5	-0.2	-0.4	1.3	0.5	0.9	-0.2	2.7	0.0	0.2
HbA1C	0.3	0.3	1.4	-1.2	-0.2	-0.1	-0.2	0.2	0.3	-0.5	-1.0	0.4	0.2
HDL Cholesterol	0.8	1.4	2.8	-1.1	1.7	1.5	-1.6	0.5	0.5	1.1	-1.3	0.6	1.1
LDL Cholesterol	0.6	1.0	2.6	-0.3	1.2	1.1	-1.1	0.4	1.6	0.4	-0.3	0.7	-1.6
Lupus	1.2	1.9	8.9	-1.1	0.9	1.1	-1.4	-0.1	3.0	0.5	-1.1	1.1	1.3
Neuroticism (2016)	1.9	2.7	7.7	0.4	1.7	1.7	-2.8	-1.6	2.1	1.0	0.1	2.5	-0.1
Primary Biliary Cirrhosis	0.4	0.5	1.5	-0.3	1.2	1.2	-0.8	-0.2	0.6	0.5	-0.3	0.9	-0.1
Rheumatoid Arthritis	1.0	1.4	5.7	-2.3	0.6	0.8	-0.2	-0.5	0.6	0.1	-2.4	0.4	1.1
Schizophrenia (2014)	0.5	1.1	3.0	0.7	-0.7	-1.1	0.5	-1.7	-0.7	1.0	0.6	-1.4	-1.3
Triglycerides	1.2	2.0	7.4	0.7	-1.6	-1.4	1.4	-1.6	-1.1	-0.8	1.0	-0.8	-2.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	1.0	-0.2	-0.3	0.6	-1.4	0.1	0.7	1.2	0.7	0.5
Ulcerative Colitis	0.3	0.4	1.0	-0.4	0.6	0.8	0.5	-0.6	0.4	0.5	-0.3	-0.8	-1.0
Blood Eosinophil Count	0.0	0.2	0.6	0.7	-0.1	-0.5	0.5	-0.1	-0.2	-0.2	0.8	-0.6	0.3
Blood Platelet Count	0.1	1.4	4.5	-1.7	-0.8	-0.3	0.3	0.9	0.2	-1.3	-1.8	-2.1	-0.3
Blood Red Count	0.3	3.0	7.2	-0.8	-2.6	-2.7	1.3	-0.7	-2.5	-1.7	-0.7	-1.4	-1.3
Blood White Count	0.6	4.4	10.8	-1.0	-3.3	-3.2	2.3	-2.4	-2.4	-1.9	-1.0	-0.9	0.0
Heel T-Score	0.6	4.4	16.2	-4.0	0.3	0.6	-1.5	-1.5	0.8	0.7	-4.0	1.8	-1.6
BMI	0.6	3.3	11.1	0.8	0.6	0.7	-2.9	-1.8	1.2	0.0	0.8	2.6	3.3
Height	0.7	13.8	27.5	5.1	-2.7	-3.2	3.6	-0.3	-3.1	5.2	5.2	-3.8	-1.6
Waist Hip Ratio (WHR)	0.8	3.7	10.2	0.4	-2.9	-3.2	2.3	-1.8	-2.3	0.7	0.6	-1.0	1.8
Systolic Blood Pressure	0.2	0.9	2.6	-1.5	0.7	0.6	-0.8	-0.4	-0.0	1.6	-1.6	0.2	0.2
Smoking Status	0.3	0.6	1.8	1.3	0.8	0.8	0.7	0.1	0.8	-0.2	1.3	-0.5	0.2
Allergy or Eczema	0.3	0.9	2.7	0.1	-1.2	-1.1	1.4	0.8	-0.2	0.8	0.1	-0.4	-1.6
Cardiovascular Disease	0.5	1.7	11.1	-0.8	-0.0	0.1	-0.3	-1.4	0.6	0.2	-0.8	1.5	3.3
Hypothyroidism (self reported)	0.4	0.8	3.8	0.1	-1.1	-0.8	-0.4	-1.2	-1.1	-1.9	0.0	-0.1	0.0
Respiratory disease	0.2	0.4	1.1	-1.0	-0.4	-0.3	-0.2	-0.4	0.5	-0.2	-1.0	0.8	0.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	7.6	1.6	0.4	0.0	-0.8	-0.5	0.8	2.8	1.5	1.4	1.0
Lung FEV1/FVC ratio	0.1	0.5	1.7	0.5	-1.1	-1.3	-0.8	-0.1	-0.1	0.1	0.6	0.2	-1.0
Lung FVC	0.3	1.6	5.6	-0.4	2.1	1.7	0.0	-0.5	0.6	2.4	-0.5	-1.0	1.0
Neuroticism	0.7	1.6	6.0	-0.3	1.3	1.7	-2.5	-0.2	1.4	0.3	-0.5	1.7	0.6
Chronotype (morning person)	0.6	1.3	4.5	1.1	0.5	0.6	1.0	1.5	0.5	0.9	1.1	-1.3	-2.1
Hair Pigment	0.0	1.1	4.0	-0.8	-0.6	-0.7	1.0	-2.0	-0.9	0.9	-0.8	-0.8	-1.2
Tanning	0.0	0.5	1.2	-0.9	0.6	0.9	-0.7	1.0	0.3	-0.1	-1.1	-0.5	0.1
Hand grip strength (left)	0.4	1.1	5.7	-1.3	0.5	0.2	0.7	-0.8	-0.8	2.4	-1.2	-0.7	-0.1
Number of treatments/medications taken	1.2	2.1	7.7	-0.1	1.5	1.9	-1.2	1.6	2.8	1.3	-0.1	0.8	1.1
Average weekly spirits intake	0.3	0.4	0.9	-0.8	-0.2	0.1	-0.6	0.6	0.7	-0.9	-0.7	0.5	-0.5
Sensitivity / hurt feelings	0.9	1.6	10.0	0.3	0.5	0.9	-3.2	-0.2	0.9	0.0	0.2	1.8	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	1.0	-1.4	-1.4	0.5	-0.5	-0.6	-0.4	0.8	-0.5	-0.5
Hearing difficulty/problems: Yes	0.7	1.0	5.1	-0.7	-0.9	-0.5	-0.6	0.4	-1.4	-2.2	-0.7	0.2	-0.7
Relative age of first facial hair	0.3	0.6	1.6	0.5	1.0	0.6	-0.8	-0.1	0.5	1.2	0.4	1.1	0.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.1	1.4	-0.7	-0.5	-0.1	0.0	0.4	-1.5	1.3	0.5	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.5	1.2	1.1	1.0	-0.9	1.4	0.5	1.9	1.1	-0.7	-0.3
Ever had hysterectomy (womb removed)	0.4	0.5	3.6	0.1	0.0	-0.0	-0.6	-1.9	-1.0	-0.2	0.1	-0.1	0.3
Systolic blood pressure, automated reading	0.3	0.9	3.1	-1.8	0.4	0.5	-1.0	-0.8	0.3	0.7	-1.8	-0.2	0.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.1	-1.3	-1.8	-1.8	2.0	-0.9	-1.9	-0.6	-1.3	-1.6	-1.0
Angina	0.7	0.9	3.4	-1.8	0.2	0.2	-0.6	0.5	0.6	1.1	-1.8	0.1	-0.4
Medication for hormone replacement therapy	0.5	0.6	3.2	0.0	-0.6	-0.2	0.1	0.8	-0.5	-1.8	0.0	-1.0	-0.3
Vitamin and mineral supplements	1.4	1.8	5.2	-0.5	-1.6	-2.1	1.6	-0.3	-2.3	-0.5	-0.2	-0.7	1.6
Supplements: Zinc	0.3	0.3	0.9	-0.6	-0.2	0.0	0.5	0.6	0.1	-0.2	-0.8	-0.3	-1.0
Medication: Co-codamol	0.4	0.5	1.1	-0.6	-1.1	-1.0	0.2	-0.6	-0.4	-1.0	-0.7	0.5	0.4
Medication: Metformin	1.6	2.3	10.4	-0.1	0.9	0.5	-0.8	-1.5	0.7	3.2	-0.0	2.3	1.6
Diabetes (father)	0.7	0.9	2.7	-0.5	-1.5	-1.3	1.6	-0.9	-0.8	0.1	-0.3	0.2	0.7
Diabetes (mother)	0.7	0.9	2.9	0.2	0.7	0.8	-0.8	-0.2	0.1	1.1	0.4	1.5	1.7
Severe depression (siblings)	1.6	1.8	5.4	2.1	1.0	0.5	-0.6	0.1	0.6	0.8	2.1	2.3	1.2
Pack years adult smoking proportion	0.8	1.2	3.6	-0.9	1.5	1.6	-1.9	0.1	0.6	0.5	-1.0	0.6	0.6
Impedance of leg (right)	0.4	2.2	4.8	0.7	-0.5	-0.6	1.8	1.8	-1.5	-2.0	0.7	-2.2	-1.6
Leg fat-free mass (left)	0.5	2.5	5.4	2.3	-1.1	-1.3	-0.4	-2.0	-0.8	2.1	2.3	0.6	1.4
Trunk fat percentage	0.5	2.2	6.9	1.6	0.2	0.4	-2.0	-1.0	0.5	-0.3	1.7	1.9	2.6
Hand grip strength (right)	0.4	1.2	3.8	-0.9	0.2	-0.1	1.6	-1.0	-1.6	2.0	-0.8	-0.2	-0.7
Townsend deprivation index at recruitment	0.6	0.8	4.0	1.0	-0.1	-0.3	-0.7	0.1	-0.4	-2.0	0.8	-0.1	1.3
Current tobacco smoking	0.6	1.0	3.9	-0.2	2.0	2.0	-0.3	0.2	1.4	0.4	-0.3	0.2	0.2
Average weekly fortified wine intake	0.4	0.5	1.7	0.1	-0.9	-0.7	0.7	-1.3	-0.0	-1.0	0.1	-0.0	0.3
Maternal smoking around birth	0.9	1.2	3.9	-0.4	-1.8	-2.0	-0.6	-1.7	-0.7	-0.8	-0.3	-0.6	-0.2
Fed-up feelings	0.4	0.7	3.3	-0.1	-0.5	-0.4	-1.4	-0.5	0.6	0.0	-0.1	1.8	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	1.2	0.5	0.3	-0.6	0.8	0.8	0.1	1.0	1.0	-0.2
Relative age voice broke	0.4	0.6	3.1	0.3	-0.8	-0.8	-0.3	0.2	-1.1	0.2	0.2	-0.1	-1.8
Taking other prescription medications	0.4	0.6	2.7	0.8	-0.0	0.4	-0.4	0.6	1.6	-0.9	0.8	0.3	0.8
Age when periods started (menarche)	0.6	1.3	4.8	0.6	-1.3	-1.1	0.4	0.8	-1.5	-0.9	0.5	-1.0	-2.2
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	8.6	-1.4	-0.4	-0.4	0.4	-2.9	0.4	0.6	-1.4	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.8	0.3	-2.2	-2.4	0.1	-0.8	-1.6	0.6	0.2	1.4	-2.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.5	-0.4	1.8	1.9	-0.7	0.6	0.9	1.7	-0.6	0.4	-1.3
Qualifications: CSEs or equivalent	0.2	0.3	1.1	-0.1	0.8	0.8	-0.4	-0.3	0.0	-0.1	-0.1	0.1	-1.1
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.9	-0.1	-0.2	-0.5	0.8	0.7	0.8	-0.9	-0.4	-0.4
High blood pressure	0.8	2.1	5.8	-2.0	-0.1	0.1	-1.1	-2.4	0.6	-0.4	-2.1	0.0	2.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.1	0.2	-1.5	-1.5	1.2	0.7	-1.0	0.3	0.1	-0.7	-2.0
Multivitamins +/- minerals	0.5	0.6	2.4	0.2	0.8	1.0	-0.7	-0.4	0.8	0.9	-0.1	0.4	-1.6
Stomach or abdominal pain in last month	1.0	1.2	4.6	0.2	-0.4	-0.3	-1.3	-2.1	-0.1	-1.4	-0.1	0.5	-1.7
Supplements: Glucosamine	0.3	0.4	1.5	-0.2	1.0	1.1	-0.2	0.2	0.5	1.2	-0.2	0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.4	0.4	0.2	0.1	-0.6	-0.6	0.4	0.2	0.4	0.6	1.2
Medication: Atenolol	2.6	3.2	5.7	-2.3	1.3	1.4	-1.6	-2.4	1.3	1.6	-2.4	1.4	1.7
Medication: Levothyroxine sodium	0.8	1.4	4.2	-0.0	-1.8	-1.7	0.6	-0.3	-1.8	-2.0	-0.0	-0.3	-0.6
Sitting height	1.5	10.6	37.9	4.6	-1.2	-1.9	3.2	-0.9	-2.4	6.2	4.7	-1.6	-0.6
Chronic bronchitis/emphysema (father)	1.0	1.2	3.4	1.7	-0.6	-0.7	0.1	1.0	-0.5	-0.8	1.8	0.9	1.5
High blood pressure (mother)	1.5	2.1	4.4	-0.9	1.9	1.9	-1.8	0.8	1.3	1.3	-1.0	2.1	0.5
Body mass index (BMI)	0.8	3.4	10.6	0.8	0.6	0.8	-2.7	-1.6	1.1	0.3	0.8	3.2	3.2
Impedance of leg (left)	0.5	2.2	6.0	0.3	-0.3	-0.3	1.9	2.4	-1.2	-1.9	0.4	-2.4	-1.2
Leg predicted mass (left)	0.5	2.5	5.5	2.3	-1.1	-1.3	-0.5	-1.9	-0.8	2.2	2.3	0.6	1.4
Trunk fat mass	0.6	2.7	7.6	2.4	-0.2	-0.0	-1.7	-1.4	0.1	0.5	2.5	1.7	2.8
Waist circumference	0.8	3.0	8.6	1.8	-0.8	-0.9	-1.4	-2.4	-0.0	1.4	1.9	1.7	2.9
Number of incorrect matches in round	0.8	1.4	4.0	2.0	0.7	0.4	0.7	1.0	1.4	0.8	1.9	0.1	-1.0
Past tobacco smoking	0.5	1.0	3.8	-2.0	-0.6	-0.7	-0.3	-0.4	-0.7	-0.4	-2.0	-0.0	0.6
Alcohol usually taken with meals	0.3	0.5	2.2	-0.7	0.3	0.3	-0.2	1.5	0.5	0.9	-0.8	-0.4	-0.2
Nervous feelings	0.3	0.6	2.1	0.3	0.5	1.0	-1.2	1.1	1.5	0.2	0.3	-0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	0.8	0.8	0.7	-0.5	-0.0	0.9	0.9	0.7	-0.3	0.1
Hearing difficulty/problems with background noise	0.4	0.6	1.8	1.4	-0.9	-0.8	-0.5	-0.2	-0.8	-0.8	1.2	0.1	0.3
Hair/balding pattern: Pattern 2	2.1	2.6	8.0	-2.0	-1.2	-0.4	-2.8	-0.8	-0.3	-1.1	-2.1	1.7	-1.8
Had menopause	0.3	0.4	1.4	-0.7	0.3	0.2	0.6	-0.6	-0.7	-0.0	-0.6	-0.2	1.2
Had other major operations	0.5	0.7	2.2	-0.3	0.1	0.5	-0.6	1.4	1.2	-1.5	-0.4	0.4	-0.2
Forced vital capacity (FVC)	0.5	1.7	5.9	1.8	0.2	-0.1	1.9	0.9	-0.1	2.4	1.9	-0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.9	0.1	-1.0	-1.1	-0.6	-0.7	-0.2	1.7	0.0	2.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.9	0.6	1.0	1.5	-0.2	-0.6	1.7	0.4	0.5	-0.7	-1.3
Qualifications: None of the above	0.5	1.1	3.0	0.3	-1.1	-1.2	1.7	-1.2	-0.7	-0.6	0.4	0.9	1.4
Financial difficulties in last 2 years	0.4	0.5	1.5	1.0	0.5	0.6	-1.2	-0.6	0.5	-0.1	0.9	-0.7	-0.3
Mouth/teeth dental problems	0.3	0.4	1.5	-0.6	-0.8	-0.8	-0.1	0.0	-0.3	-1.2	-0.6	0.3	0.6
Heart attack	1.5	1.9	6.2	-2.4	0.6	0.8	-1.5	-1.2	0.9	1.1	-2.5	-0.0	0.0
Allergy	0.1	0.2	0.4	-0.5	0.5	0.5	-0.5	0.1	0.4	-0.6	-0.4	-0.2	0.6
Pain all over the body in last month	0.8	0.8	1.5	1.1	0.9	0.8	-1.2	0.7	1.1	0.8	0.9	-0.4	-0.9
Diabetes (self-reported)	1.1	1.7	6.2	1.0	0.6	0.2	-0.8	-1.3	0.6	2.5	0.9	1.7	1.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.0	0.8	-0.4	-0.5	0.6	1.7	0.7	1.2	0.9	-0.8	-0.7
Medication: Ramipril	2.5	3.2	12.3	-3.5	0.8	1.2	-1.0	-1.3	1.1	1.2	-3.5	0.2	0.4
Medication: Simvastatin	1.2	1.8	4.3	-0.3	1.8	1.8	-0.6	0.5	1.8	1.9	-0.3	0.3	2.1
Fluid intelligence score	0.2	0.5	1.9	0.3	-0.7	-0.7	-0.3	0.8	-0.9	-0.4	0.3	-1.4	-0.6
Illnesses of siblings	1.6	2.2	7.0	2.1	-1.0	-1.0	1.8	0.4	-0.9	0.3	2.1	-0.8	-2.6
Neuroticism score	0.9	1.8	7.0	0.6	0.9	1.0	-2.7	-0.3	1.2	0.6	0.5	2.1	1.6
Weight	0.6	3.0	8.3	2.8	-0.7	-0.7	-1.0	-1.6	-0.4	1.5	2.9	1.5	2.3
Impedance of arm (right)	0.3	1.5	5.3	-0.5	-0.6	-0.5	1.4	0.5	-0.9	-1.8	-0.4	-2.3	-1.5
Arm fat percentage (right)	0.9	3.6	11.1	0.6	0.9	1.2	-2.8	-2.0	1.3	-0.0	0.7	2.9	3.3
Trunk fat-free mass	0.7	4.1	11.5	3.4	-1.2	-1.5	0.8	-1.6	-1.2	2.9	3.4	-0.3	1.0
Hip circumference	0.5	2.1	5.7	2.1	-0.0	0.0	-1.6	-1.5	0.1	0.1	2.1	1.4	2.4
Time employed in main current job	3.0	3.5	7.5	1.6	2.3	2.5	-1.2	2.5	2.7	1.5	1.5	1.0	0.4
Alcohol intake versus 10 years previously	0.5	0.7	2.9	0.5	-1.7	-1.5	0.3	-0.5	-0.4	-0.6	0.5	0.7	0.1
Father’s age at death	0.5	0.7	2.1	0.7	0.4	0.6	0.3	1.4	0.2	-0.8	0.7	0.8	-1.3
Worrier / anxious feelings	0.2	0.5	1.1	1.0	0.6	0.7	0.4	0.8	0.0	0.5	0.9	-0.2	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	4.0	1.7	-0.1	0.1	-1.2	0.2	1.3	-0.4	1.4	-0.2	-2.0
Falls in the last year	1.1	1.5	4.2	0.5	1.7	1.8	-0.6	2.1	1.1	0.4	0.3	-1.4	-0.6
Hair/balding pattern: Pattern 3	1.1	1.7	5.6	1.1	-0.7	-1.0	2.4	1.5	-0.4	-0.0	1.3	-1.8	-1.1
Number of live births	1.0	1.4	4.4	-1.6	0.0	0.0	1.4	-0.8	-1.0	-0.9	-1.5	-2.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.8	1.8	-0.3	-0.8	1.9	0.8	-0.3	2.0	1.9	-0.9	-0.4
Pulse rate	0.8	1.3	5.1	-0.6	-1.3	-1.0	-0.3	-1.8	-0.5	-2.3	-0.6	-0.8	0.7
Happiness	0.7	0.8	4.1	0.6	0.1	0.1	0.3	-1.0	-0.2	0.8	0.6	-2.0	-1.2
Noisy workplace	0.4	0.5	2.4	-0.2	-0.2	-0.4	0.7	-1.5	-0.3	-0.1	-0.0	0.1	1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	5.9	0.0	-0.2	-0.1	-0.5	0.8	0.2	0.7	-0.1	-2.4	-2.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.6	0.7	-1.0	-0.8	0.9	-1.6	-0.5	-0.2	0.8	-0.9	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	2.4	-0.6	-0.6	-0.5	1.1	-1.6	-0.3	0.1	-0.5	-0.4	-0.1
Asthma	0.1	0.3	0.9	-0.9	-0.1	-0.1	0.0	-0.9	-0.2	-0.2	-0.8	-0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	8.9	3.0	0.0	0.1	-0.7	0.7	0.3	0.3	2.8	1.3	-2.2
Medication: Cholesterol lowering	0.8	1.3	4.6	-0.9	0.6	0.7	-0.3	0.1	1.3	1.8	-0.9	0.8	2.1
Depression (self-reported)	0.9	1.1	2.6	1.4	0.3	0.4	-1.6	1.2	1.5	0.7	1.2	0.5	-0.5
Medication: Lansoprazole	2.7	3.1	6.2	1.4	2.5	2.5	-2.4	0.9	2.1	0.8	1.3	1.5	0.8
Prospective memory result	0.5	0.7	1.6	-1.3	-0.6	-0.3	0.0	-0.1	0.3	-1.3	-1.2	0.8	-0.9
Lung cancer (father)	1.0	1.2	2.7	1.0	-1.5	-1.6	1.4	1.4	-0.7	0.3	1.0	-0.5	-0.4
Illnesses of mother	2.2	2.8	7.4	-0.7	-2.1	-2.0	1.7	-1.2	-1.3	-2.2	-0.7	-2.7	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	6.0	2.5	-0.8	-1.4	1.6	1.0	-1.0	2.4	2.4	-1.1	-0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-0.3	1.2	1.3	-0.3	-0.6	-0.0	-0.6	-0.3	-0.7	-1.3
Impedance of arm (left)	0.3	1.5	4.2	-0.4	-0.5	-0.4	1.3	1.0	-0.6	-1.9	-0.4	-2.1	-1.8
Arm fat mass (right)	0.7	2.9	9.1	1.5	0.1	0.2	-1.9	-2.0	0.4	0.6	1.5	2.6	3.0
Trunk predicted mass	0.7	4.0	10.9	3.3	-1.3	-1.5	0.7	-1.7	-1.3	2.8	3.3	-0.2	1.1
Standing height	1.0	10.3	21.4	4.5	-2.8	-3.2	3.5	-0.2	-3.1	2.7	4.6	-3.4	-1.5
Length of working week for main job	0.2	0.3	1.6	0.3	-0.2	-0.5	1.3	-0.3	-0.0	0.5	0.3	-0.2	0.4
Exposure to tobacco smoke at home	0.5	0.6	1.4	1.0	0.7	0.5	0.5	1.2	-0.2	1.1	1.0	0.4	0.7
Breastfed as a baby	1.0	1.3	3.9	2.0	0.3	0.1	0.9	1.0	0.1	1.3	2.0	-0.7	1.1
Tense / ‘highly strung’	0.3	0.6	2.5	-0.8	0.3	0.5	-1.6	-1.0	0.7	-0.1	-0.9	0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.0	1.7	1.5	1.5	-0.5	2.0	2.0	1.2	1.7	0.0	-0.0
Hair/balding pattern: Pattern 4	0.2	0.5	3.2	0.1	0.5	0.1	-0.1	1.8	-0.5	-0.2	0.0	-0.2	1.0
Birth weight of first child	0.2	0.3	1.0	1.0	-0.1	0.1	-0.9	0.2	-0.2	-0.1	1.0	0.2	0.0
Peak expiratory flow (PEF)	0.3	0.6	2.0	0.6	0.6	0.1	1.4	-0.6	-0.2	1.0	0.7	-1.3	-0.5
Pulse wave reflection index	1.0	1.2	7.7	-0.3	1.3	1.4	-0.5	0.4	0.2	0.2	-0.4	-0.2	-2.8
Ever highly irritable/argumentative for 2 days	1.5	1.8	7.8	1.3	-0.4	-0.0	-0.4	2.8	0.5	-0.6	1.5	2.2	-0.2
Loud music exposure frequency	0.7	0.8	1.4	0.9	1.1	1.2	-0.4	-0.5	1.2	1.1	0.9	-0.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.1	0.7	-0.2	0.0	-1.8	1.0	0.6	0.3	0.6	-0.5	-1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.9	-0.1	0.5	0.4	-0.6	1.4	0.1	0.3	-0.1	0.3	1.2
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.7	0.6	0.7	0.8	-0.3	0.4	-0.9	-0.6	0.2	0.3
Medication: Paracetamol	0.8	1.3	2.2	1.5	1.3	1.5	-1.3	0.1	1.3	1.1	1.3	0.5	-0.3
Headache pain in last month	0.4	0.6	1.4	1.2	-0.7	-0.8	0.5	0.8	-0.6	-0.8	1.0	-0.8	-0.5
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	6.0	1.5	-1.9	-2.1	2.0	0.1	-2.4	-1.9	1.4	-0.8	-2.4
Glaucoma (self-reported)	0.7	0.8	2.8	0.2	-0.9	-0.8	-0.0	-1.7	0.9	-0.3	0.3	0.8	1.4
Gout (self-reported)	0.6	0.8	1.9	1.1	0.5	0.1	1.1	0.6	-0.4	1.0	1.1	-1.4	-0.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	6.2	0.2	-1.9	-1.7	0.7	-1.6	-2.0	-2.5	0.2	-0.6	-0.9
Medication: Amlodipine	0.9	1.2	3.1	-0.6	1.4	1.5	-0.5	-1.0	1.8	1.7	-0.5	0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.4	-1.4	0.5	0.5	-1.8	-0.6	0.2	0.3	-1.4	0.4	1.7
Birth weight	1.0	2.1	5.6	1.7	1.3	1.2	-0.2	1.1	0.9	2.4	1.8	1.0	1.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.6	-0.6	0.9	1.2	-1.6	-0.9	0.9	-0.2	-0.6	0.9	-0.1
High blood pressure (siblings)	0.9	1.3	3.7	-1.9	-0.1	-0.1	-0.6	-1.4	-0.9	-0.4	-1.9	-1.0	0.8
Forced vital capacity (FVC), Best measure	0.8	2.8	8.2	2.6	-0.0	-0.6	1.6	1.0	-0.6	2.9	2.6	-1.2	-0.5
Body fat percentage	0.7	2.6	9.4	1.3	0.4	0.6	-2.3	-1.2	0.6	-0.4	1.4	2.3	3.1
Leg fat percentage (right)	0.7	2.5	8.4	1.2	0.7	0.8	-2.1	-1.1	0.8	-0.6	1.3	2.3	2.9
Arm fat-free mass (right)	0.6	3.3	9.7	3.1	-1.3	-1.5	0.2	-0.9	-1.1	2.3	3.1	0.3	1.4
Exposure to tobacco smoke outside home	1.0	1.4	5.2	1.1	-0.9	-0.5	0.0	0.9	-0.4	-2.3	1.0	-1.1	-1.7
Comparative body size at age 10	2.0	5.5	14.7	-0.7	3.2	2.8	-2.5	0.1	1.7	3.8	-0.7	2.8	2.2
Number of full brothers	0.7	0.9	2.9	0.8	-0.7	-0.6	0.8	-0.4	-1.7	-1.6	0.7	-0.4	-0.4
Worry too long after embarrassment	1.1	1.9	4.7	0.9	1.5	1.4	-2.2	-0.3	0.8	1.7	0.9	1.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.0	1.7	1.1	1.3	-0.8	1.4	1.3	1.6	1.5	0.3	-1.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.8	-0.4	0.5	0.4	-0.6	-0.7	0.3	1.4	-0.6	-0.1	-0.6
Number of children fathered	0.4	0.4	1.1	-1.0	0.4	0.5	0.2	-0.6	0.4	0.5	-1.1	0.5	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.1	-0.4	-0.8	-1.1	0.2	-0.5	-0.4	1.2	-0.3	-1.4	-0.2
Age at first live birth	0.7	1.2	4.8	-0.5	-0.8	-0.9	-0.2	0.6	-1.4	-0.2	-0.6	-1.8	-2.2
Pulse wave peak to peak time	0.7	0.8	2.7	0.5	-1.5	-1.6	0.5	0.6	-0.3	0.8	0.5	0.4	1.1
Health satisfaction	0.7	0.9	3.4	1.8	-0.6	-0.4	0.2	0.1	0.1	-0.8	1.8	-0.4	-1.0
Shortness of breath walking on level ground	1.3	1.5	6.5	-1.9	0.3	0.4	-0.1	-2.5	-0.8	-0.7	-1.9	0.5	-0.1
Qualifications: College or University degree	0.5	1.6	4.3	2.0	0.3	-0.0	0.6	1.9	-0.1	0.4	2.1	-1.8	-0.8
Eye problems/disorders: None of the above	0.3	0.3	1.1	0.7	-0.3	-0.5	0.3	0.1	-0.7	0.0	0.8	1.1	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	0.5	0.8	0.5	0.2	1.0	0.8	1.0	0.4	-0.6	1.4
Emphysema/chronic bronchitis	0.7	0.7	2.2	1.5	0.4	0.4	0.1	-0.0	0.9	0.5	1.5	-1.2	0.5
Medication for pain relief, constipation, heartburn	0.7	1.3	3.6	-0.7	-1.3	-1.6	1.3	-0.6	-1.9	-0.9	-0.5	-1.1	0.2
Neck or shoulder pain in last month	0.5	0.7	2.2	0.8	-0.6	-0.5	-1.4	-0.9	-0.0	0.3	0.7	1.5	0.0
Medication: Blood pressure	1.7	3.1	5.3	-2.2	1.3	1.7	-2.3	-1.2	1.8	1.0	-2.2	0.4	2.2
Angina (self-reported)	0.6	0.8	3.0	-1.7	0.3	0.2	-0.4	0.3	0.5	1.3	-1.7	0.1	-0.2
Migraine (self-reported)	1.5	1.9	7.6	-2.1	0.2	0.1	0.0	-2.7	-0.6	0.7	-2.2	-0.3	1.0
Medication: Ibuprofen	1.7	2.1	6.1	2.3	1.0	1.2	-0.3	1.1	1.0	0.5	2.1	0.5	-2.5
Medication: Allopurinol	1.6	2.1	7.1	1.8	0.3	-0.2	1.7	0.4	-0.4	1.6	1.8	-2.7	-1.3
Medication: Omeprazole	0.5	0.6	2.1	-0.7	0.7	1.2	-0.5	0.5	1.5	-0.6	-0.8	-0.3	0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.8	-0.9	-1.0	-0.9	-0.0	-0.2	0.0	-1.3	-0.8	-1.0	-0.3
Mean time to correctly identify matches	0.2	0.5	1.3	0.7	0.9	0.8	0.1	1.1	0.5	0.3	0.6	0.2	0.7
Heart disease (mother)	1.2	1.5	5.2	0.3	-0.2	-0.4	-1.9	2.2	-0.0	0.9	0.3	2.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.2	-0.9	-1.1	-1.3	0.2	0.8	-0.7	-0.5	-0.9	0.0	-1.8
Whole body fat mass	0.7	2.8	8.8	1.9	0.0	0.1	-2.0	-1.6	0.2	0.4	1.9	2.3	3.0
Leg fat mass (right)	0.8	2.9	9.6	1.9	-0.0	0.1	-1.8	-1.7	0.4	0.2	1.9	2.5	3.1
Arm predicted mass (right)	0.8	4.1	12.5	3.5	-1.3	-1.6	0.3	-1.1	-1.1	2.6	3.5	0.6	1.3
Pulse rate, automated reading	0.3	0.9	3.6	0.9	-0.3	0.4	-1.2	-1.0	0.8	-1.9	0.9	0.2	0.8
Alcohol intake frequency.	0.3	0.8	2.0	-0.9	-0.2	0.1	0.5	0.9	1.2	-1.2	-0.9	0.1	1.4
Comparative height size at age 10	0.6	3.4	6.8	1.4	-2.6	-2.6	2.5	-0.5	-2.0	1.2	1.6	-2.1	-0.4
Number of full sisters	1.5	1.9	4.9	-1.3	-0.9	-1.1	1.7	-0.6	-1.7	-2.2	-1.2	-1.0	1.0
Suffer from ‘nerves’	0.3	0.5	2.6	-0.2	0.2	0.1	-1.6	-0.7	0.7	0.4	-0.1	0.8	0.7
Overall health rating	0.6	1.3	5.8	2.4	-0.5	-0.5	-0.4	0.1	0.8	-0.6	2.3	0.1	-0.2
Chest pain or discomfort	0.7	1.0	3.1	-1.2	0.4	0.2	-1.8	-0.5	0.7	1.1	-1.3	-1.0	-0.5
Had major operations	0.1	0.2	0.7	0.4	-0.2	-0.0	0.3	0.1	0.5	-0.2	0.3	0.9	-0.4
Age at last live birth	1.0	1.5	6.2	0.1	0.8	0.6	-0.0	1.4	0.1	1.1	-0.1	-2.5	-2.1
Family relationship satisfaction	0.7	0.9	5.7	-0.2	0.5	-0.1	-0.5	-1.0	0.4	2.4	-0.2	-0.7	1.0
Leg pain on walking	1.0	1.3	2.9	0.6	1.5	1.5	-0.9	1.1	1.7	0.7	0.7	1.0	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	-0.1	0.8	0.8	0.5	0.6	-0.0	-0.8	-0.1	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	0.7	-0.7	-0.9	1.2	-0.4	-1.4	-1.0	0.6	0.5	-0.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	9.5	-1.7	0.3	0.4	-0.6	0.3	-0.3	-0.3	-1.6	1.4	3.1
Medication: Aspirin	1.2	1.6	5.8	-1.0	0.9	1.1	-0.8	0.5	2.4	2.1	-1.0	0.7	-0.1
Supplements: Vitamin C	0.4	0.5	0.9	-0.2	0.6	1.0	-0.9	1.0	0.9	-0.4	-0.3	0.4	-0.6
Knee pain experienced in last month	0.5	0.8	2.0	1.3	-0.4	-0.3	-0.8	0.5	0.6	-0.1	1.4	1.4	0.7
Hypertension (Self-reported)	0.8	2.2	5.0	-2.2	0.2	0.4	-1.4	-2.0	1.0	-0.2	-2.2	0.0	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.1	1.3	-0.5	-0.3	0.2	1.7	0.4	-1.8	1.4	-0.6	0.3
Illnesses of father: Heart disease	2.0	2.8	6.8	0.3	2.1	1.9	-2.6	1.7	2.0	2.3	0.2	0.2	0.7
Illnesses of siblings: Diabetes	0.8	1.0	6.0	-1.0	0.4	0.4	-0.8	-0.4	0.9	-0.1	-0.8	0.4	2.5
Smoking status: Previous	0.5	0.8	3.2	1.7	-0.3	-0.1	1.0	0.3	0.2	0.3	1.8	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.6	7.9	2.8	-1.9	-2.1	1.9	1.6	-1.5	0.8	2.8	-1.3	-1.5
Whole body fat-free mass	0.6	3.4	8.9	3.0	-1.3	-1.5	0.3	-1.7	-1.1	2.6	3.0	0.2	1.3
Leg fat-free mass (right)	0.4	2.2	4.9	2.2	-1.1	-1.2	-0.1	-1.5	-0.6	2.2	2.2	0.4	1.3
Arm fat percentage (left)	0.8	3.1	9.4	0.6	0.7	0.9	-2.6	-1.9	1.0	-0.2	0.7	2.8	3.1
Average weekly red wine intake	0.9	1.4	9.2	-0.4	0.7	0.3	0.4	-1.2	-0.1	1.3	-0.4	-0.3	3.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.8	-1.7	-1.3	-1.2	1.0	-0.1	-0.9	-0.6	-1.7	0.7	-1.3
Mood swings	0.7	1.3	3.6	0.3	-1.9	-1.9	-0.1	-0.4	-1.4	-1.2	0.3	1.6	-0.3
Loneliness, isolation	0.2	0.3	0.9	-0.0	0.3	0.2	-0.8	-0.9	1.0	0.2	-0.1	0.2	-0.1
Long-standing illness, disability or infirmity	0.4	0.7	1.3	1.1	-1.1	-0.9	-0.9	-0.0	-0.4	-0.7	1.1	0.3	0.8
Ever had bowel cancer screening	0.8	0.9	2.4	0.3	1.2	1.6	0.2	0.5	1.5	1.0	0.3	-0.4	1.2
Diabetes diagnosed by doctor	0.8	1.3	7.5	0.7	0.1	-0.3	-0.4	-1.1	-0.0	2.7	0.7	1.1	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	-0.2	-0.6	-0.7	-0.4	1.0	0.2	-1.4	-0.1	0.4	0.8
Friendships satisfaction	0.4	0.5	3.4	0.6	0.7	0.3	-0.5	0.4	0.4	1.8	0.6	0.1	0.4
Qualifications: nursing, teaching	0.2	0.2	1.2	-0.3	-0.6	-0.6	-0.3	-0.1	-0.1	-1.1	-0.3	0.3	-0.1
Commuting to job workplace: Walk	1.1	1.2	2.3	1.5	1.2	1.2	-1.5	0.6	0.5	0.5	1.4	1.2	0.5
Eye problems/disorders: Cataract	1.1	1.2	4.0	-0.9	1.2	1.1	-2.0	1.6	0.5	0.4	-1.0	-0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	0.8	1.0	1.0	-0.9	0.7	0.5	-0.3	0.7	0.9	-0.0
Medication for cholesterol	0.1	0.2	0.6	0.7	-0.0	-0.1	-0.2	0.6	-0.3	0.1	0.8	-0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	1.0	0.5	0.5	-0.3	1.1	1.2	0.2	1.0	-0.0	0.9
Back pain experienced in last month	0.9	1.4	2.9	-1.1	-1.4	-0.9	-1.0	-0.3	-0.2	-1.7	-1.0	1.4	-1.7
Mineral and other dietary supplements	0.6	0.8	3.7	0.1	-0.6	-0.6	-0.8	-0.3	-0.2	-1.9	0.1	0.3	1.6
Breast cancer (self-reported)	0.4	0.5	1.1	-1.1	-0.4	-0.6	-0.1	0.4	0.4	1.0	-1.0	0.8	0.8
Asthma (self-reported)	0.1	0.3	0.5	-0.7	-0.5	-0.5	0.5	-0.5	-0.5	-0.3	-0.6	-0.7	-0.1
Osteoporosis (self-reported)	0.6	0.8	1.9	1.4	-0.1	0.3	-0.3	0.7	1.4	-1.0	1.4	-0.0	0.7
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.9	-0.2	-0.2	-0.1	-0.7	-0.2	-0.3	-0.9	-0.6	0.1
Medication: Aspirin	1.0	1.4	5.2	-0.8	0.7	0.9	-0.8	0.0	2.3	2.2	-0.9	0.5	-0.1
Medication: Gliclazide	1.1	1.2	4.3	1.0	0.3	-0.3	-0.9	0.1	0.3	1.5	1.1	2.1	1.5
Illnesses of father: None of the above (group 1)	1.1	1.4	3.5	-1.1	-1.2	-1.2	1.9	-1.3	-1.4	0.1	-0.9	-1.1	0.0
Smoking status: Current	0.6	1.0	3.9	-0.1	2.0	1.9	-0.2	0.4	1.4	0.8	-0.2	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.1	1.1	1.2	0.8	-0.4	1.6	0.6	2.0	1.1	-0.2	0.5
Whole body water mass	0.6	3.5	9.6	3.1	-1.1	-1.4	0.2	-1.7	-1.0	2.6	3.1	0.4	1.4
Leg predicted mass (right)	0.4	2.2	4.8	2.1	-1.1	-1.3	-0.1	-1.6	-0.6	2.2	2.1	0.4	1.3
Arm fat mass (left)	0.8	3.3	9.2	1.7	0.2	0.4	-2.3	-2.1	0.6	0.6	1.8	2.8	3.0
Number of self-reported non-cancer illnesses	0.4	0.7	3.5	-0.1	0.0	0.4	-0.4	-0.2	1.5	-0.6	-0.1	0.7	1.9
Average weekly champagne plus white wine intake	0.7	1.0	3.8	0.7	-1.0	-0.9	0.5	2.0	-0.1	0.4	0.7	-0.7	-1.5
Miserableness	1.0	1.7	8.2	1.4	0.1	0.5	-2.9	-0.7	1.4	-0.2	1.4	1.4	0.4
Guilty feelings	1.3	2.0	2.8	1.6	1.0	0.8	-1.7	-1.3	1.2	1.5	1.5	1.6	1.6
Wears glasses or contact lenses	0.1	0.2	1.1	-0.1	0.2	0.4	0.4	1.1	0.2	-0.2	-0.2	-0.2	0.2
Ever taken oral contraceptive pill	0.2	0.3	1.4	-0.4	0.4	0.4	-0.2	1.2	0.1	0.8	-0.3	-0.2	-0.0
Hearing aid user	1.2	1.4	5.6	0.6	-2.4	-2.1	1.0	0.1	-0.8	-0.9	0.7	0.5	0.6
Mother’s age at death	0.7	0.8	3.7	-0.2	-1.0	-0.6	1.0	0.3	-0.7	-1.1	-0.4	-0.3	-1.9
Financial situation satisfaction	1.0	1.2	3.8	-0.4	1.9	1.8	-0.7	-1.0	1.2	1.0	-0.4	0.3	0.8
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.7	0.4	1.6	1.4	-2.0	1.6	1.1	0.4	0.4	2.2	1.6
Commuting to job workplace: Public transport	0.5	0.6	2.3	0.1	-0.5	-0.5	-1.0	-0.6	-1.2	0.1	0.1	-1.5	-0.8
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	1.1	-0.6	-0.4	0.3	-1.6	1.0	0.1	1.1	-0.1	-0.3
Medication: Blood pressure	0.6	1.1	5.3	-1.2	-1.0	-1.0	0.4	-2.3	-0.6	-0.5	-1.2	0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	-0.4	-1.2	-1.1	1.0	-0.4	0.4	-1.0	-0.5	1.4	1.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.9	0.3	-0.2	0.2	0.8	0.3	0.2	0.8	0.2	0.7	-1.4
High cholesterol (Self-reported)	0.6	1.1	3.0	-0.5	1.0	1.2	-1.0	0.1	1.1	0.7	-0.5	1.4	1.7
Medication: Bendroflumethiazide	0.6	0.8	3.8	0.1	-1.0	-1.0	-0.1	-2.0	-0.9	-0.7	0.1	1.0	0.2
Medication: Paracetamol	0.8	1.2	2.3	1.5	1.1	1.3	-0.9	0.2	1.5	1.0	1.5	0.7	-0.2
Medication: Lisinopril	2.5	3.2	8.6	-0.7	2.0	1.7	-2.9	-0.4	1.2	1.6	-0.6	2.1	2.7
Medication: Atorvastatin	0.4	0.5	1.5	-1.1	-0.4	-0.2	-0.4	-1.1	0.6	0.4	-1.2	0.7	-0.0
Illnesses of father: High blood pressure	0.4	0.5	2.2	-0.1	-0.3	-0.2	-0.4	-1.2	0.4	-1.0	-0.3	1.5	0.5
Alcohol drinker status: Never	0.4	0.5	1.1	-0.0	1.0	1.0	0.5	-0.2	1.0	-0.8	-0.1	0.5	0.6
Ever smoked	0.2	0.4	1.0	0.9	-0.1	-0.1	0.6	-1.0	-0.6	-0.8	0.9	-0.1	-0.2
Basal metabolic rate	0.6	3.3	9.4	3.0	-1.1	-1.3	0.0	-1.6	-0.9	2.3	3.1	0.5	1.6
Leg fat percentage (left)	0.6	2.4	9.9	1.2	0.6	0.8	-1.9	-0.7	0.8	-0.5	1.3	2.1	3.2
Arm fat-free mass (left)	0.8	3.8	10.9	3.2	-1.3	-1.5	0.1	-1.6	-1.1	2.4	3.3	0.6	1.7
Number of operations (self-reported)	0.4	0.5	2.4	-0.0	0.2	0.6	-0.6	0.0	1.0	-1.1	-0.1	1.6	-0.3
Average weekly beer plus cider intake	2.7	3.9	10.4	0.0	-3.2	-2.8	1.2	-2.3	-2.2	-2.6	0.0	0.5	-1.5
Irritability	0.6	1.0	2.5	1.6	-1.2	-1.0	-0.1	0.2	-0.4	-1.5	1.5	0.3	-0.1
Risk taking	0.4	0.6	2.8	0.1	-0.3	0.0	-1.2	-0.7	0.3	0.2	0.1	0.9	-1.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.2	-0.3	0.7	1.1	-0.5	1.1	1.8	-0.7	-0.3	1.2	0.3
Fractured/broken bones in last 5 years	2.1	2.8	6.8	-0.3	1.2	1.4	-2.0	2.6	2.2	0.9	-0.3	2.2	1.7
Age started oral contraceptive pill	0.4	0.5	2.5	0.4	0.2	0.1	-1.0	0.5	0.7	1.6	0.4	-0.0	-0.3
Diastolic blood pressure, automated reading	0.3	0.9	2.7	-1.1	0.5	0.8	-1.0	-0.7	0.3	-1.7	-1.2	0.1	1.2
Ever depressed for a whole week	0.7	0.9	1.9	-1.3	0.8	1.3	-0.3	-0.7	1.1	-0.5	-1.4	-0.8	-0.7
Unable to work because of sickness or disability	1.3	1.6	6.3	2.5	0.0	0.0	-0.6	1.6	0.4	-0.9	2.5	-0.2	0.1
Commuting to job workplace: Cycle	0.4	0.5	2.0	0.4	0.0	0.1	-1.2	0.8	-0.1	0.2	0.2	-0.9	-1.4
Myopia	1.1	1.6	4.5	1.5	-1.5	-1.3	1.5	-0.5	-0.2	-2.1	1.5	0.4	0.0
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.7	2.4	0.1	-0.2	0.8	2.1	-0.6	-0.1	2.4	0.3	-2.0
Cholesterol lowering medication	0.6	0.9	2.2	-0.2	1.3	1.3	-0.9	-0.4	1.5	1.4	-0.3	0.8	0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.9	-1.0	1.5	2.0	-0.8	1.1	1.7	-0.3	-1.1	0.1	0.6
Pain experienced in last month	0.8	1.4	5.7	0.2	1.1	0.7	1.3	1.0	0.3	2.4	0.4	-1.4	1.2
Supplements: Calcium	1.3	1.4	3.6	-1.8	0.1	0.2	-1.2	-1.6	0.4	0.8	-1.9	1.1	1.2
Basal cell carcinoma (self-reported)	0.7	0.9	1.5	0.8	-1.2	-1.1	1.1	0.1	-0.8	-1.2	0.9	1.2	-0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.3	-2.3	0.7	0.8	-1.3	-1.2	1.0	1.1	-2.3	0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.3	-0.7	0.9	1.1	0.6	-0.2	0.9	-1.1	-0.7	0.4	0.3
Heart disease (siblings)	1.7	2.1	5.3	-1.1	1.4	1.1	-1.8	0.2	1.2	1.4	-1.0	1.9	2.3
Alcohol drinker status: Previous	0.3	0.4	1.1	-0.0	-0.6	-0.5	0.5	1.0	1.0	0.4	0.1	0.4	0.6
Pack years of smoking	0.8	1.1	2.3	-0.9	1.5	1.5	-1.5	-0.2	0.7	0.5	-0.9	1.1	0.9
Impedance of whole body	0.4	2.0	6.1	0.0	-0.5	-0.5	1.7	1.7	-1.0	-1.9	0.1	-2.5	-1.7
Leg fat mass (left)	0.7	2.9	10.6	2.0	-0.1	-0.1	-1.6	-1.5	0.3	0.1	2.0	2.3	3.2
Arm predicted mass (left)	0.8	3.9	12.0	3.4	-0.9	-1.1	-0.1	-1.3	-0.8	2.7	3.5	0.6	1.8