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chr11:111,051,115-112,491,227

Best TWAS P=4.68e-08 · Best GWAS P=4.38e-08 conditioned to 0.0147

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	The Cancer Genome Atlas	Lung Adenocarcinoma	HSPB2	0.03	0.01	blup	5	0.03	2.3e-04	-5.3	-5.5	4.7e-08	0.67	0.00	0.90	TRUE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIK2	0.04	0.01	blup	35	0.01	6.7e-03	-5.3	-5.4	5.9e-08	0.92	0.02	0.90	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf1	0.04	0.03	blup	5	0.02	1.8e-03	-5.3	5.4	6.3e-08	-0.62	0.00	0.83	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	FDXACB1	0.08	0.07	lasso	3	0.05	5.6e-04	-5.3	5.4	7.0e-08	-0.68	0.00	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C11orf1	0.06	0.06	lasso	5	0.05	4.4e-07	-5.3	5.4	8.5e-08	-0.71	0.04	0.96	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	C11orf1	0.11	0.07	enet	2	0.08	3.4e-05	-5.3	5.4	8.5e-08	-0.66	0.00	0.96	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRYAB	0.03	0.02	lasso	1	0.01	2.2e-03	-5.3	-5.3	1.1e-07	0.67	0.00	0.94	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	FDXACB1	0.13	0.05	lasso	1	0.05	2.4e-06	-5.3	5.3	1.1e-07	-0.67	0.00	1.00	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FDXACB1	0.03	0.02	lasso	1	0.02	5.9e-03	-5.3	5.3	1.1e-07	-0.67	0.00	0.85	FALSE
5	GTEx	Skin Sun Exposed Lower leg	C11orf1	0.06	0.05	lasso	2	0.02	9.6e-03	-5.3	5.3	1.3e-07	-0.69	0.04	0.92	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	C11orf1	0.04	0.02	lasso	2	0.03	2.1e-04	-5.3	5.3	1.3e-07	-0.66	0.02	0.98	FALSE
3	GTEx	Skin Not Sun Exposed Suprapubic	CRYAB	0.12	0.10	lasso	5	0.07	7.7e-05	-5.3	-5.3	1.4e-07	0.67	0.04	0.96	FALSE
2	GTEx	Muscle Skeletal	C11orf1	0.04	0.05	lasso	4	0.02	3.5e-03	-5.3	5.2	1.5e-07	-0.67	0.04	0.93	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	FDXACB1	0.06	0.00	blup	5	0.02	4.5e-03	-5.3	5.2	1.7e-07	-0.57	0.00	0.46	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf1	0.07	0.06	enet	3	0.08	7.0e-09	-5.3	5.2	1.9e-07	-0.66	0.00	1.00	FALSE
4	GTEx	Skin Sun Exposed Lower leg	CRYAB	0.07	0.04	lasso	10	0.02	1.3e-02	-5.3	-5.2	2.4e-07	0.69	0.04	0.92	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIK2	0.05	0.06	lasso	1	0.05	2.6e-06	-5.2	-5.2	2.4e-07	0.95	0.02	0.98	FALSE