Best TWAS P=3.15e-11 · Best GWAS P=6.7e-10 conditioned to 0.34
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PM20D1 | 0.27 | 0.41 | enet | 15 | 0.41 | 7.8e-54 | 6.0 | 6.0 | 1.6e-09 | -0.75 | 0.00 | 1.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | SLC26A9 | 0.13 | 0.16 | lasso | 3 | 0.16 | 3.1e-19 | 6.0 | 6.0 | 1.9e-09 | -0.76 | 0.00 | 1.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RAB7L1 | 0.17 | 0.08 | enet | 15 | 0.10 | 1.2e-05 | -3.6 | 5.1 | 2.8e-07 | -0.54 | 0.48 | 0.48 | FALSE |
4 | GTEx | Artery Tibial | NUCKS1 | 0.13 | 0.03 | lasso | 2 | 0.01 | 4.0e-02 | 5.7 | -5.8 | 7.0e-09 | 0.70 | 0.03 | 0.92 | FALSE |
5 | GTEx | Brain Cerebellum | NUCKS1 | 0.22 | 0.13 | lasso | 3 | 0.08 | 2.0e-03 | 5.7 | -5.2 | 1.7e-07 | 0.72 | 0.07 | 0.77 | FALSE |
6 | GTEx | Esophagus Mucosa | RAB7L1 | 0.26 | 0.11 | enet | 34 | 0.18 | 4.5e-12 | -4.1 | 5.8 | 7.5e-09 | -0.62 | 0.04 | 0.96 | FALSE |
7 | GTEx | Lung | RAB7L1 | 0.34 | 0.19 | enet | 53 | 0.31 | 7.5e-24 | -3.5 | 5.3 | 1.1e-07 | -0.57 | 0.32 | 0.68 | FALSE |
8 | GTEx | Nerve Tibial | SLC41A1 | 0.12 | 0.02 | lasso | 4 | 0.05 | 2.5e-04 | 6.0 | 5.2 | 1.7e-07 | -0.70 | 0.03 | 0.96 | FALSE |
9 | GTEx | Pancreas | SLC41A1 | 0.24 | 0.21 | lasso | 5 | 0.19 | 1.4e-08 | 6.0 | 6.0 | 1.5e-09 | -0.77 | 0.00 | 1.00 | FALSE |
10 | GTEx | Prostate | NUCKS1 | 0.38 | 0.23 | lasso | 8 | 0.32 | 7.5e-09 | -6.1 | 6.3 | 2.7e-10 | -0.95 | 0.01 | 0.98 | FALSE |
11 | GTEx | Testis | NUCKS1 | 0.16 | 0.16 | enet | 15 | 0.16 | 1.3e-07 | 5.1 | -5.2 | 2.4e-07 | 0.74 | 0.08 | 0.92 | FALSE |
12 | GTEx | Thyroid | NUCKS1 | 0.26 | 0.16 | lasso | 6 | 0.19 | 1.8e-14 | 4.9 | -5.1 | 2.9e-07 | 0.64 | 0.09 | 0.91 | FALSE |
13 | METSIM | Adipose | NUCKS1 | 0.05 | 0.02 | lasso | 6 | 0.01 | 4.3e-03 | 5.1 | -5.2 | 1.8e-07 | 0.70 | 0.09 | 0.86 | FALSE |
14 | METSIM | Adipose | PM20D1 | 0.25 | 0.30 | bslmm | 377 | 0.31 | 8.4e-47 | 6.0 | -5.6 | 2.2e-08 | 0.83 | 0.00 | 1.00 | FALSE |
15 | METSIM | Adipose | SLC41A1 | 0.07 | 0.08 | lasso | 7 | 0.08 | 1.9e-11 | -6.1 | 6.0 | 1.8e-09 | -0.94 | 0.00 | 1.00 | FALSE |
16 | YFS | Blood | NUCKS1 | 0.15 | 0.24 | lasso | 4 | 0.25 | 1.4e-80 | 4.9 | -5.2 | 2.3e-07 | 0.66 | 0.66 | 0.34 | FALSE |
17 | YFS | Blood | SLC41A1 | 0.06 | 0.05 | enet | 15 | 0.05 | 2.6e-17 | 5.7 | 5.4 | 5.8e-08 | -0.73 | 0.01 | 0.99 | FALSE |
18 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PM20D1 | 0.22 | 0.26 | lasso | 5 | 0.26 | 1.7e-22 | 5.7 | -6.2 | 4.8e-10 | 0.85 | 0.01 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PM20D1 | 0.24 | 0.37 | lasso | 5 | 0.39 | 4.9e-85 | 6.0 | -6.3 | 3.6e-10 | 0.83 | 0.00 | 1.00 | FALSE |
20 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PM20D1 | 0.18 | 0.19 | blup | 47 | 0.18 | 1.9e-09 | 6.0 | -5.1 | 2.8e-07 | 0.74 | 0.00 | 1.00 | FALSE |
21 | The Cancer Genome Atlas | Colon Adenocarcinoma | PM20D1 | 0.26 | 0.13 | enet | 14 | 0.16 | 9.7e-10 | -6.1 | -5.8 | 5.4e-09 | 0.86 | 0.00 | 1.00 | FALSE |
22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PM20D1 | 0.19 | 0.25 | lasso | 5 | 0.25 | 3.0e-28 | 6.0 | -6.3 | 3.0e-10 | 0.86 | 0.01 | 0.99 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PM20D1 | 0.29 | 0.35 | enet | 18 | 0.35 | 5.1e-41 | 6.0 | -6.6 | 3.2e-11 | 0.86 | 0.00 | 1.00 | TRUE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAB7L1 | 0.09 | 0.08 | enet | 11 | 0.08 | 1.7e-09 | -4.3 | 5.1 | 2.9e-07 | -0.64 | 0.61 | 0.39 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PM20D1 | 0.19 | 0.19 | enet | 4 | 0.19 | 4.5e-11 | 6.0 | -6.1 | 8.4e-10 | 0.81 | 0.01 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PM20D1 | 0.41 | 0.43 | enet | 20 | 0.44 | 9.2e-55 | 6.0 | -5.8 | 6.0e-09 | 0.79 | 0.00 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Lung Adenocarcinoma | PM20D1 | 0.31 | 0.39 | enet | 16 | 0.41 | 5.1e-52 | 6.0 | -6.3 | 3.3e-10 | 0.82 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB7L1 | 0.02 | 0.02 | enet | 5 | 0.03 | 4.6e-04 | -3.9 | 5.7 | 1.6e-08 | -0.83 | 0.01 | 0.86 | FALSE |
29 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PM20D1 | 0.26 | 0.34 | lasso | 3 | 0.34 | 1.9e-40 | 6.0 | -6.3 | 2.3e-10 | 0.88 | 0.00 | 1.00 | FALSE |
30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PM20D1 | 0.12 | 0.13 | blup | 47 | 0.12 | 9.1e-09 | 6.0 | -6.0 | 2.2e-09 | 0.76 | 0.00 | 1.00 | FALSE |
31 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RAB7L1 | 0.06 | 0.06 | blup | 46 | 0.06 | 5.2e-05 | 4.9 | 5.7 | 1.5e-08 | -0.82 | 0.05 | 0.93 | FALSE |
32 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PM20D1 | 0.32 | 0.34 | lasso | 2 | 0.34 | 9.7e-15 | 5.7 | -5.8 | 5.9e-09 | 0.74 | 0.01 | 0.99 | FALSE |
33 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PM20D1 | 0.34 | 0.13 | enet | 20 | 0.21 | 9.7e-09 | -5.0 | -5.4 | 6.3e-08 | 0.82 | 0.01 | 0.99 | FALSE |
34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PM20D1 | 0.16 | 0.14 | enet | 15 | 0.16 | 5.6e-16 | 6.0 | -6.3 | 2.7e-10 | 0.90 | 0.00 | 1.00 | FALSE |
35 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PM20D1 | 0.23 | 0.24 | lasso | 4 | 0.24 | 1.2e-14 | 6.0 | -6.3 | 3.3e-10 | 0.83 | 0.00 | 1.00 | FALSE |
36 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | PM20D1 | 0.17 | 0.11 | lasso | 3 | 0.07 | 5.0e-03 | 6.0 | -6.1 | 1.1e-09 | 0.78 | 0.01 | 0.82 | FALSE |
37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PM20D1 | 0.09 | 0.11 | enet | 6 | 0.10 | 1.3e-07 | -6.2 | -6.2 | 5.1e-10 | 0.96 | 0.00 | 1.00 | FALSE |
38 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RAB7L1 | 0.07 | 0.04 | blup | 46 | 0.07 | 1.2e-05 | 5.7 | 5.3 | 1.1e-07 | -0.65 | 0.03 | 0.94 | FALSE |
39 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PM20D1 | 0.42 | 0.34 | lasso | 3 | 0.34 | 6.9e-13 | 6.0 | -5.8 | 7.1e-09 | 0.61 | 0.01 | 0.99 | FALSE |
40 | The Cancer Genome Atlas | Thyroid Carcinoma | PM20D1 | 0.26 | 0.40 | lasso | 4 | 0.41 | 2.0e-42 | 6.0 | -6.1 | 8.6e-10 | 0.82 | 0.00 | 1.00 | FALSE |
41 | The Cancer Genome Atlas | Thyroid Carcinoma | RAB7L1 | 0.13 | 0.17 | enet | 15 | 0.21 | 3.6e-20 | -4.1 | 5.5 | 5.2e-08 | -0.71 | 0.24 | 0.76 | FALSE |
42 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | PM20D1 | 0.19 | 0.09 | lasso | 4 | 0.12 | 4.2e-04 | 5.7 | -5.8 | 7.7e-09 | 0.77 | 0.01 | 0.83 | FALSE |