[Hub]/) : Traits : Suffer from 'nerves' : ← →

chr11:46,578,400-48,559,571

Best TWAS P=2.91e-17 · Best GWAS P=4.59e-16 conditioned to 0.595

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-6.505	-6.7	2.2e-11	0.91	0.06	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	2.093	-5.4	6.1e-08	0.74	0.03	0.78	FALSE
3	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-6.523	6.9	6.2e-12	-0.91	0.54	0.46	FALSE
4	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	-6.505	6.5	7.8e-11	-0.86	0.05	0.91	FALSE
5	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	1.263	-5.4	6.3e-08	0.60	0.12	0.42	FALSE
6	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-8.046	-7.8	4.8e-15	0.98	0.01	0.97	FALSE
7	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	5.529	6.4	1.2e-10	-0.78	0.03	0.41	FALSE
8	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-6.231	6.0	1.7e-09	-0.89	0.04	0.86	FALSE
9	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-6.218	-6.7	2.9e-11	0.87	0.03	0.55	FALSE
10	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	5.408	-6.8	1.2e-11	0.84	0.30	0.70	FALSE
11	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	1.398	-5.3	1.4e-07	0.24	0.51	0.08	FALSE
12	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	1.145	-5.1	3.0e-07	0.79	0.04	0.68	FALSE
13	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	-7.864	6.4	1.9e-10	-0.85	0.02	0.98	FALSE
14	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	-6.523	5.9	3.0e-09	-0.84	0.04	0.83	FALSE
15	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-6.523	7.2	8.0e-13	-0.94	0.02	0.93	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	2.694	-5.7	1.6e-08	0.57	0.13	0.55	FALSE
17	GTEx	Esophagus Mucosa	MADD	0.27	0.04	enet	18	0.12	4.1e-08	4.014	-5.7	1.3e-08	0.33	0.27	0.04	FALSE
18	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	-6.505	6.5	7.8e-11	-0.86	0.14	0.85	FALSE
19	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-7.864	-7.9	3.7e-15	0.90	0.02	0.96	FALSE
20	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	4.835	-5.4	6.0e-08	0.20	0.73	0.01	FALSE
21	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	-6.523	5.4	5.8e-08	-0.86	0.09	0.90	FALSE
22	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-6.505	6.7	3.0e-11	-0.91	0.04	0.95	FALSE
23	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	-6.505	6.5	7.8e-11	-0.86	0.19	0.46	FALSE
24	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-6.505	8.1	7.4e-16	-0.84	0.04	0.94	FALSE
25	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-6.249	7.0	2.3e-12	-0.94	0.04	0.96	FALSE
26	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-7.954	-7.4	1.8e-13	0.92	0.03	0.97	FALSE
27	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-6.505	7.2	7.3e-13	-0.93	0.08	0.92	FALSE
28	GTEx	Nerve Tibial	NR1H3	0.10	0.00	enet	24	0.08	4.7e-06	2.903	5.5	5.2e-08	-0.46	0.04	0.50	FALSE
29	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	-6.505	6.4	1.5e-10	-0.89	0.80	0.20	FALSE
30	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	6.053	-8.2	1.7e-16	0.70	0.03	0.95	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-6.505	6.4	1.6e-10	-0.81	0.11	0.89	FALSE
32	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-6.505	7.2	6.0e-13	-0.91	0.10	0.90	FALSE
33	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-8.046	7.8	8.1e-15	-0.95	0.02	0.98	FALSE
34	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-6.231	-6.2	5.0e-10	0.90	0.08	0.92	FALSE
35	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	5.422	6.1	1.4e-09	-0.66	0.72	0.14	FALSE
36	GTEx	Thyroid	MADD	0.11	0.00	enet	13	0.01	6.1e-02	0.027	-5.4	6.1e-08	0.33	0.06	0.08	FALSE
37	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-8.012	8.0	1.5e-15	-1.00	0.02	0.98	FALSE
38	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-7.932	7.9	2.6e-15	-0.98	0.03	0.97	FALSE
39	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	-6.231	5.6	2.6e-08	-0.85	0.16	0.84	FALSE
40	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-7.864	7.9	3.7e-15	-0.97	0.02	0.98	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-7.932	-7.8	5.0e-15	0.97	0.03	0.97	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	5.475	-6.0	1.7e-09	0.61	0.98	0.02	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	-5.951	5.3	1.0e-07	-0.88	0.05	0.95	FALSE
44	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	6.190	-7.0	2.4e-12	0.75	0.05	0.92	FALSE
45	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	-8.122	-5.3	9.5e-08	0.80	0.02	0.97	FALSE
46	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	-5.936	5.2	2.0e-07	-0.70	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-7.912	7.7	1.2e-14	-0.97	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	4.835	-7.2	5.2e-13	0.58	0.04	0.95	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-6.249	6.4	1.6e-10	-0.81	0.01	0.97	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	-7.970	-7.1	9.5e-13	0.84	0.01	0.65	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	-6.505	6.5	7.8e-11	-0.86	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	5.693	-5.3	9.7e-08	0.84	0.00	0.51	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	5.422	-5.9	3.8e-09	0.74	0.08	0.22	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	4.824	-5.5	3.7e-08	0.64	0.02	0.80	FALSE
55	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-6.505	6.8	1.2e-11	-0.91	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-7.932	7.9	2.3e-15	-0.98	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-8.122	-7.2	6.0e-13	0.82	0.00	0.99	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	-5.448	5.5	4.2e-08	-0.76	0.02	0.97	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-7.910	-8.2	2.4e-16	0.91	0.01	0.97	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	2.286	-5.4	6.5e-08	0.67	0.01	0.68	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-7.932	7.6	2.9e-14	-0.96	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MADD	0.20	0.07	enet	9	0.08	2.4e-09	4.835	-5.3	1.1e-07	0.31	0.62	0.33	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-7.856	7.9	4.0e-15	-0.97	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-6.242	-6.3	3.6e-10	0.88	0.01	0.98	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	-5.954	-6.4	1.7e-10	0.60	0.01	0.93	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-7.932	-7.9	2.2e-15	0.98	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-7.932	7.9	2.2e-15	-0.98	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	-6.161	-5.9	4.6e-09	0.86	0.01	0.98	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-6.505	7.3	2.0e-13	-0.90	0.00	0.96	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	MADD	0.15	0.04	enet	10	0.06	4.5e-07	4.835	-5.5	4.4e-08	0.29	0.18	0.13	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-7.954	-8.4	2.9e-17	0.94	0.01	0.90	TRUE
72	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-7.882	7.7	1.3e-14	-0.97	0.00	0.93	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	-6.505	6.6	4.5e-11	-0.80	0.01	0.84	FALSE