[Hub]/) : Traits : Suffer from 'nerves' : ← →

chr8:8,092,025-11,748,645

Best TWAS P=2.23e-11 · Best GWAS P=5.13e-10 conditioned to 0.128

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PINX1	0.07	0.07	enet	7	0.08	4.9e-10	5.4	-5.5	4.3e-08	-0.51	0.57	0.43	FALSE
2	GTEx	Adipose Subcutaneous	AF131215.9	0.20	0.12	enet	60	0.17	1.1e-13	4.5	-5.5	3.8e-08	-0.55	0.83	0.17	FALSE
3	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	-5.1	-5.6	2.2e-08	-0.70	0.29	0.67	FALSE
4	GTEx	Adipose Visceral Omentum	AF131215.9	0.18	0.16	lasso	7	0.16	2.0e-08	-5.1	-5.2	1.7e-07	-0.73	0.77	0.23	FALSE
5	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	-5.3	-5.3	8.9e-08	-0.76	0.64	0.35	FALSE
6	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	-5.3	-5.3	1.2e-07	-0.74	0.57	0.41	FALSE
7	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	4.5	-5.4	5.6e-08	-0.80	0.26	0.72	FALSE
8	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	-4.8	-5.2	2.1e-07	-0.74	0.62	0.34	FALSE
9	GTEx	Artery Coronary	AC087269.1	0.20	0.02	enet	29	0.02	8.7e-02	-4.6	5.6	2.2e-08	0.48	0.11	0.30	FALSE
10	GTEx	Artery Coronary	AF131215.2	0.11	0.02	enet	27	0.05	6.5e-03	3.1	-5.4	6.7e-08	-0.55	0.09	0.61	FALSE
11	GTEx	Artery Tibial	AF131215.2	0.07	0.03	enet	24	0.05	1.8e-04	5.1	-6.0	2.4e-09	-0.67	0.14	0.84	FALSE
12	GTEx	Artery Tibial	AF131215.9	0.08	0.01	lasso	10	0.02	1.8e-02	4.4	-5.2	1.7e-07	-0.64	0.14	0.78	FALSE
13	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-5.2	5.9	3.8e-09	0.65	0.14	0.84	FALSE
14	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	5.1	-5.4	5.4e-08	-0.67	0.20	0.33	FALSE
15	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	-5.5	5.7	1.5e-08	0.65	0.11	0.88	FALSE
16	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-5.3	5.4	5.4e-08	0.61	0.11	0.49	FALSE
17	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	-4.7	5.2	1.6e-07	0.59	0.10	0.76	FALSE
18	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	4.5	-5.4	8.1e-08	-0.83	0.17	0.82	FALSE
19	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	6.0	-6.3	3.7e-10	-0.93	0.06	0.94	FALSE
20	GTEx	Breast Mammary Tissue (Female)	AF131215.2	0.04	-0.01	lasso	2	0.00	4.8e-01	6.0	-6.0	2.6e-09	-0.95	0.06	0.24	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	AF131215.2	0.20	0.10	enet	14	0.11	1.5e-04	5.1	-5.3	1.2e-07	-0.70	0.46	0.45	FALSE
22	GTEx	Cells Transformed fibroblasts	FAM86B3P	0.23	0.33	lasso	11	0.38	8.4e-30	-5.4	-5.9	4.4e-09	-0.64	0.13	0.87	FALSE
23	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	-5.6	-5.8	7.4e-09	-0.72	0.17	0.36	FALSE
24	GTEx	Colon Sigmoid	AF131215.9	0.11	0.17	enet	5	0.09	4.9e-04	5.1	-5.4	6.9e-08	-0.67	0.33	0.25	FALSE
25	GTEx	Colon Transverse	AF131215.2	0.15	0.09	enet	32	0.07	3.1e-04	-4.8	-5.3	1.1e-07	-0.66	0.41	0.48	FALSE
26	GTEx	Colon Transverse	AF131215.9	0.12	0.14	enet	18	0.12	4.0e-06	5.1	-5.9	4.5e-09	-0.65	0.64	0.32	FALSE
27	GTEx	Esophagus Mucosa	FAM86B3P	0.22	0.17	lasso	8	0.19	1.7e-12	-5.4	-5.5	3.5e-08	-0.63	0.12	0.88	FALSE
28	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	4.4	-5.5	3.1e-08	-0.71	0.94	0.06	FALSE
29	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	-5.3	-5.7	9.9e-09	-0.77	0.67	0.32	FALSE
30	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	5.1	-5.2	1.9e-07	-0.65	0.72	0.28	FALSE
31	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	-5.2	-5.4	6.6e-08	-0.71	0.34	0.28	FALSE
32	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	5.1	-5.7	1.5e-08	-0.70	0.53	0.40	FALSE
33	GTEx	Lung	AF131215.2	0.12	0.08	lasso	5	0.08	1.0e-06	5.1	-5.4	6.8e-08	-0.66	0.65	0.35	FALSE
34	GTEx	Lung	AF131215.9	0.15	0.18	lasso	4	0.15	1.5e-11	5.1	-5.2	1.6e-07	-0.64	0.79	0.21	FALSE
35	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	4.4	-5.3	9.6e-08	-0.76	0.92	0.08	FALSE
36	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	5.1	-5.6	2.6e-08	-0.73	0.76	0.23	FALSE
37	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	-4.8	-5.2	1.9e-07	-0.74	0.83	0.17	FALSE
38	GTEx	Pituitary	FAM86B3P	0.13	0.15	lasso	4	0.13	3.5e-04	4.9	5.3	1.3e-07	0.54	0.10	0.66	FALSE
39	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	-5.5	-6.7	2.2e-11	-0.79	0.09	0.44	TRUE
40	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	4.4	-5.2	1.6e-07	-0.73	0.87	0.13	FALSE
41	GTEx	Skin Sun Exposed Lower leg	MSRA	0.10	0.02	lasso	4	0.01	8.5e-02	-4.4	5.1	3.0e-07	0.61	0.31	0.31	FALSE
42	GTEx	Skin Sun Exposed Lower leg	AF131215.2	0.14	0.11	lasso	9	0.16	4.3e-13	4.4	-5.1	2.8e-07	-0.70	0.97	0.03	FALSE
43	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	5.1	-5.9	3.2e-09	-0.73	0.86	0.14	FALSE
44	GTEx	Spleen	AF131215.2	0.16	0.08	enet	14	0.06	1.1e-02	5.1	-6.2	6.8e-10	-0.74	0.26	0.38	FALSE
45	GTEx	Spleen	AF131215.9	0.34	0.23	enet	16	0.15	1.2e-04	-5.3	-5.5	3.3e-08	-0.69	0.46	0.31	FALSE
46	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	-5.3	5.5	4.4e-08	0.63	0.22	0.77	FALSE
47	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	4.4	-5.7	1.3e-08	-0.73	0.84	0.15	FALSE
48	GTEx	Thyroid	AF131215.9	0.11	0.08	enet	16	0.17	4.7e-13	5.1	-5.7	1.2e-08	-0.71	0.76	0.24	FALSE
49	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	-5.3	-5.6	1.9e-08	-0.79	0.16	0.46	FALSE
50	GTEx	Uterus	AF131215.9	0.16	-0.01	enet	18	0.03	7.5e-02	-5.3	-5.6	2.1e-08	-0.66	0.14	0.39	FALSE
51	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	-5.3	-5.4	5.9e-08	-0.73	0.21	0.60	FALSE
52	NTR	Blood	MFHAS1	0.02	0.01	blup	759	0.01	2.9e-04	-5.3	-5.7	1.1e-08	-0.60	0.39	0.60	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	5.0	-5.4	5.7e-08	-0.71	0.49	0.51	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	-5.4	5.8	5.9e-09	0.64	0.14	0.86	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	-5.1	-5.6	1.6e-08	-0.77	0.74	0.26	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	AF131215.2	0.49	0.57	lasso	7	0.57	9.0e-89	5.1	-5.2	1.7e-07	-0.64	0.79	0.21	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ10661	0.10	0.16	lasso	1	0.15	6.1e-13	-5.5	-5.5	3.6e-08	-0.62	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	RP1L1	0.02	0.01	lasso	2	0.01	4.1e-03	-5.7	-5.4	8.2e-08	-0.53	0.01	0.87	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ10661	0.15	0.26	lasso	4	0.23	3.0e-13	-5.5	-5.6	1.9e-08	-0.62	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ10661	0.07	0.14	lasso	3	0.14	3.7e-15	-5.5	-5.5	4.3e-08	-0.62	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ10661	0.07	0.02	blup	42	0.04	2.9e-03	-5.5	-5.3	1.4e-07	-0.61	0.01	0.93	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	-5.3	5.7	1.1e-08	0.60	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FLJ10661	0.09	0.07	blup	41	0.07	3.6e-04	4.3	-5.1	3.1e-07	-0.57	0.04	0.61	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ10661	0.06	0.05	lasso	3	0.04	2.4e-05	-5.5	-5.3	9.7e-08	-0.58	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ10661	0.08	0.05	blup	42	0.07	9.3e-06	-5.5	-5.2	2.1e-07	-0.60	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ10661	0.24	0.36	enet	8	0.35	4.1e-13	-5.5	-5.3	1.2e-07	-0.60	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	4.9	5.7	1.5e-08	0.60	0.59	0.40	FALSE