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chr16:30,347,731-31,758,245

Best TWAS P=1.71e-08 · Best GWAS P=2.56e-08 conditioned to 0.329

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HSD3B7	0.05	0.06	lasso	4	0.07	5.5e-09	-5.4	-5.4	6.6e-08	0.88	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	RP11-196G11.2	0.23	0.20	lasso	9	0.21	4.2e-17	-5.5	-5.6	2.8e-08	0.94	0.02	0.98	FALSE
3	GTEx	Artery Aorta	STX1B	0.17	0.18	lasso	6	0.15	1.9e-08	-5.4	-5.5	3.2e-08	0.91	0.03	0.97	FALSE
4	GTEx	Artery Aorta	RP11-196G11.2	0.10	0.16	lasso	2	0.14	7.1e-08	-5.3	-5.4	7.6e-08	0.94	0.04	0.96	FALSE
5	GTEx	Artery Coronary	RP11-196G11.2	0.12	0.06	lasso	6	0.06	3.4e-03	-5.5	-5.6	1.7e-08	0.92	0.02	0.93	TRUE
6	GTEx	Brain Cerebellar Hemisphere	STX1B	0.13	0.11	lasso	5	0.10	1.5e-03	-5.3	-5.5	4.6e-08	0.95	0.04	0.72	FALSE
7	GTEx	Brain Cerebellum	STX1B	0.24	0.16	lasso	11	0.18	4.8e-06	-5.2	-5.3	1.1e-07	0.87	0.04	0.95	FALSE
8	GTEx	Brain Cerebellum	STX4	0.14	0.25	lasso	1	0.24	8.3e-08	-5.3	-5.3	9.0e-08	0.92	0.04	0.95	FALSE
9	GTEx	Brain Cerebellum	RP11-196G11.2	0.31	0.30	lasso	4	0.36	1.3e-11	-5.3	-5.4	5.4e-08	0.93	0.04	0.96	FALSE
10	GTEx	Breast Mammary Tissue (Male)	RP11-196G11.2	0.15	0.16	lasso	4	0.09	3.9e-03	-5.2	-5.2	1.7e-07	0.91	0.04	0.90	FALSE
11	GTEx	Cells Transformed fibroblasts	RP11-196G11.2	0.14	0.14	lasso	6	0.13	2.9e-10	-5.4	-5.5	4.5e-08	0.93	0.03	0.97	FALSE
12	GTEx	Colon Transverse	STX4	0.10	0.09	lasso	3	0.06	6.6e-04	-5.2	-5.2	1.9e-07	0.90	0.04	0.91	FALSE
13	GTEx	Colon Transverse	RP11-196G11.2	0.24	0.11	lasso	5	0.15	1.9e-07	-5.3	-5.3	8.8e-08	0.92	0.03	0.97	FALSE
14	GTEx	Esophagus Mucosa	STX1B	0.12	0.03	lasso	5	0.05	1.7e-04	-5.4	-5.6	2.8e-08	0.82	0.04	0.96	FALSE
15	GTEx	Esophagus Mucosa	STX4	0.08	0.00	enet	21	0.02	1.0e-02	-5.1	-5.4	7.9e-08	0.85	0.06	0.90	FALSE
16	GTEx	Esophagus Mucosa	RP11-196G11.2	0.09	0.03	enet	13	0.05	1.5e-04	-5.5	-5.5	4.5e-08	0.87	0.03	0.95	FALSE
17	GTEx	Esophagus Muscularis	STX4	0.05	0.05	lasso	3	0.03	6.7e-03	-5.3	-5.4	7.2e-08	0.91	0.03	0.94	FALSE
18	GTEx	Esophagus Muscularis	RP11-196G11.2	0.14	0.14	lasso	6	0.13	3.7e-08	-5.5	-5.2	1.7e-07	0.90	0.02	0.98	FALSE
19	GTEx	Heart Left Ventricle	HSD3B7	0.12	0.08	lasso	3	0.07	2.0e-04	-5.3	-5.4	7.8e-08	0.98	0.05	0.94	FALSE
20	GTEx	Lung	RP11-196G11.2	0.21	0.12	enet	22	0.14	1.6e-10	-5.4	-5.4	5.9e-08	0.84	0.04	0.96	FALSE
21	GTEx	Muscle Skeletal	STX4	0.04	0.04	lasso	3	0.03	2.9e-04	-5.4	-5.4	8.5e-08	0.90	0.03	0.97	FALSE
22	GTEx	Muscle Skeletal	RP11-196G11.2	0.15	0.10	enet	10	0.12	1.0e-11	-5.4	-5.3	1.1e-07	0.90	0.03	0.97	FALSE
23	GTEx	Nerve Tibial	STX1B	0.21	0.14	enet	17	0.18	1.6e-12	-5.2	-5.2	1.9e-07	0.93	0.05	0.95	FALSE
24	GTEx	Nerve Tibial	HSD3B7	0.09	0.05	lasso	3	0.03	2.4e-03	-5.4	-5.5	3.0e-08	0.90	0.04	0.85	FALSE
25	GTEx	Nerve Tibial	RP11-196G11.2	0.17	0.22	lasso	6	0.22	2.3e-15	-5.3	-5.6	2.7e-08	0.95	0.03	0.97	FALSE
26	GTEx	Ovary	RP11-196G11.2	0.41	0.22	lasso	10	0.25	6.0e-07	-5.4	-5.5	3.1e-08	0.96	0.04	0.96	FALSE
27	GTEx	Pancreas	STX1B	0.23	0.18	lasso	3	0.16	2.8e-07	-5.2	-5.2	1.9e-07	0.90	0.05	0.95	FALSE
28	GTEx	Pancreas	RP11-196G11.2	0.13	0.11	lasso	1	0.11	2.5e-05	-5.3	-5.3	1.4e-07	0.91	0.04	0.94	FALSE
29	GTEx	Pituitary	HSD3B7	0.13	0.07	lasso	7	0.05	2.1e-02	-5.3	-5.4	7.9e-08	0.98	0.05	0.86	FALSE
30	GTEx	Pituitary	RP11-196G11.2	0.21	0.28	lasso	6	0.23	1.4e-06	-5.5	-5.3	1.1e-07	0.95	0.03	0.96	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	RP11-196G11.2	0.22	0.21	lasso	9	0.26	3.2e-14	-5.5	-5.5	4.8e-08	0.96	0.02	0.98	FALSE
32	GTEx	Skin Sun Exposed Lower leg	STX1B	0.05	0.04	enet	4	0.05	7.2e-05	-5.2	-5.3	1.1e-07	0.92	0.04	0.95	FALSE
33	GTEx	Skin Sun Exposed Lower leg	HSD3B7	0.12	0.17	lasso	5	0.16	2.7e-13	-5.1	-5.3	1.2e-07	0.97	0.06	0.94	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RP11-196G11.2	0.16	0.15	lasso	7	0.15	4.0e-12	-5.4	-5.6	1.9e-08	0.92	0.03	0.97	FALSE
35	GTEx	Stomach	RP11-196G11.2	0.25	0.16	enet	21	0.14	4.6e-07	-3.8	-5.1	2.7e-07	0.83	0.15	0.84	FALSE
36	GTEx	Testis	STX1B	0.26	0.23	lasso	5	0.25	1.2e-11	-5.3	-5.4	6.9e-08	0.90	0.04	0.96	FALSE
37	GTEx	Testis	RP11-196G11.2	0.14	0.11	lasso	4	0.13	3.1e-06	-5.3	-5.4	6.2e-08	0.93	0.03	0.96	FALSE
38	GTEx	Thyroid	RP11-196G11.2	0.11	0.14	lasso	2	0.14	3.5e-11	-5.4	-5.5	4.3e-08	0.92	0.03	0.97	FALSE
39	GTEx	Uterus	RP11-196G11.2	0.18	0.16	lasso	20	0.15	5.4e-04	-5.5	-5.4	5.1e-08	0.96	0.04	0.92	FALSE
40	GTEx	Whole Blood	RP11-196G11.2	0.07	0.05	lasso	3	0.06	1.4e-06	-5.3	-5.2	2.4e-07	0.91	0.05	0.94	FALSE
41	METSIM	Adipose	RP11-196G11.2	0.13	0.17	lasso	9	0.16	2.2e-23	-5.4	-5.4	5.5e-08	0.88	0.03	0.97	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	STX1B	0.08	0.10	lasso	7	0.10	3.0e-12	-5.3	-5.3	1.3e-07	0.98	0.04	0.96	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	HSD3B7	0.03	0.05	lasso	6	0.02	3.0e-04	-5.3	-5.2	2.2e-07	0.90	0.03	0.96	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	STX4	0.06	0.11	lasso	10	0.11	1.4e-13	-5.3	5.2	1.6e-07	-0.93	0.03	0.96	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	RP11-196G11.2	0.12	0.12	lasso	4	0.12	1.1e-14	-5.4	-5.4	5.8e-08	0.88	0.03	0.97	FALSE
46	YFS	Blood	STX4	0.03	0.06	lasso	2	0.05	4.3e-17	-5.4	-5.4	5.6e-08	0.89	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HSD3B7	0.04	0.02	enet	13	0.03	2.1e-03	-5.4	-5.6	1.9e-08	0.93	0.02	0.63	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRSS53	0.03	0.03	blup	38	0.02	6.8e-06	-5.3	5.2	2.4e-07	-0.86	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BCL7C	0.04	0.01	blup	29	0.02	6.9e-03	-5.3	5.6	2.3e-08	-0.86	0.01	0.82	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD3B7	0.08	0.05	blup	31	0.05	1.8e-03	-5.1	-5.1	2.6e-07	0.98	0.02	0.93	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	-5.4	-5.4	8.7e-08	0.95	0.02	0.56	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD3B7	0.09	0.12	blup	31	0.11	4.1e-05	-5.5	-5.5	4.8e-08	0.97	0.02	0.96	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD3B7	0.24	0.27	lasso	6	0.26	2.0e-27	-5.1	-5.2	2.2e-07	0.97	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS53	0.06	0.02	enet	7	0.04	4.7e-05	-5.3	5.3	1.1e-07	-0.89	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	STX1B	0.04	0.03	blup	32	0.04	9.5e-05	-5.4	-5.3	1.4e-07	0.96	0.02	0.96	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	HSD3B7	0.20	0.27	lasso	12	0.28	1.8e-27	-5.4	-5.3	1.0e-07	0.98	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	PRSS53	0.11	0.04	enet	8	0.05	9.7e-06	-5.4	5.3	1.3e-07	-0.80	0.01	0.98	FALSE