[Hub]/) : Traits : Neuroticism score :

chr16:30,347,731-31,758,245

Best TWAS P=1.71e-08 · Best GWAS P=2.56e-08 conditioned to 0.329

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD3B7 0.05 0.06 lasso 4 0.07 5.5e-09 -5.4 -5.4 6.6e-08 0.88 0.03 0.97 FALSE
2 GTEx Adipose Subcutaneous RP11-196G11.2 0.23 0.20 lasso 9 0.21 4.2e-17 -5.5 -5.6 2.8e-08 0.94 0.02 0.98 FALSE
3 GTEx Artery Aorta STX1B 0.17 0.18 lasso 6 0.15 1.9e-08 -5.4 -5.5 3.2e-08 0.91 0.03 0.97 FALSE
4 GTEx Artery Aorta RP11-196G11.2 0.10 0.16 lasso 2 0.14 7.1e-08 -5.3 -5.4 7.6e-08 0.94 0.04 0.96 FALSE
5 GTEx Artery Coronary RP11-196G11.2 0.12 0.06 lasso 6 0.06 3.4e-03 -5.5 -5.6 1.7e-08 0.92 0.02 0.93 TRUE
6 GTEx Brain Cerebellar Hemisphere STX1B 0.13 0.11 lasso 5 0.10 1.5e-03 -5.3 -5.5 4.6e-08 0.95 0.04 0.72 FALSE
7 GTEx Brain Cerebellum STX1B 0.24 0.16 lasso 11 0.18 4.8e-06 -5.2 -5.3 1.1e-07 0.87 0.04 0.95 FALSE
8 GTEx Brain Cerebellum STX4 0.14 0.25 lasso 1 0.24 8.3e-08 -5.3 -5.3 9.0e-08 0.92 0.04 0.95 FALSE
9 GTEx Brain Cerebellum RP11-196G11.2 0.31 0.30 lasso 4 0.36 1.3e-11 -5.3 -5.4 5.4e-08 0.93 0.04 0.96 FALSE
10 GTEx Breast Mammary Tissue (Male) RP11-196G11.2 0.15 0.16 lasso 4 0.09 3.9e-03 -5.2 -5.2 1.7e-07 0.91 0.04 0.90 FALSE
11 GTEx Cells Transformed fibroblasts RP11-196G11.2 0.14 0.14 lasso 6 0.13 2.9e-10 -5.4 -5.5 4.5e-08 0.93 0.03 0.97 FALSE
12 GTEx Colon Transverse STX4 0.10 0.09 lasso 3 0.06 6.6e-04 -5.2 -5.2 1.9e-07 0.90 0.04 0.91 FALSE
13 GTEx Colon Transverse RP11-196G11.2 0.24 0.11 lasso 5 0.15 1.9e-07 -5.3 -5.3 8.8e-08 0.92 0.03 0.97 FALSE
14 GTEx Esophagus Mucosa STX1B 0.12 0.03 lasso 5 0.05 1.7e-04 -5.4 -5.6 2.8e-08 0.82 0.04 0.96 FALSE
15 GTEx Esophagus Mucosa STX4 0.08 0.00 enet 21 0.02 1.0e-02 -5.1 -5.4 7.9e-08 0.85 0.06 0.90 FALSE
16 GTEx Esophagus Mucosa RP11-196G11.2 0.09 0.03 enet 13 0.05 1.5e-04 -5.5 -5.5 4.5e-08 0.87 0.03 0.95 FALSE
17 GTEx Esophagus Muscularis STX4 0.05 0.05 lasso 3 0.03 6.7e-03 -5.3 -5.4 7.2e-08 0.91 0.03 0.94 FALSE
18 GTEx Esophagus Muscularis RP11-196G11.2 0.14 0.14 lasso 6 0.13 3.7e-08 -5.5 -5.2 1.7e-07 0.90 0.02 0.98 FALSE
19 GTEx Heart Left Ventricle HSD3B7 0.12 0.08 lasso 3 0.07 2.0e-04 -5.3 -5.4 7.8e-08 0.98 0.05 0.94 FALSE
20 GTEx Lung RP11-196G11.2 0.21 0.12 enet 22 0.14 1.6e-10 -5.4 -5.4 5.9e-08 0.84 0.04 0.96 FALSE
21 GTEx Muscle Skeletal STX4 0.04 0.04 lasso 3 0.03 2.9e-04 -5.4 -5.4 8.5e-08 0.90 0.03 0.97 FALSE
22 GTEx Muscle Skeletal RP11-196G11.2 0.15 0.10 enet 10 0.12 1.0e-11 -5.4 -5.3 1.1e-07 0.90 0.03 0.97 FALSE
23 GTEx Nerve Tibial STX1B 0.21 0.14 enet 17 0.18 1.6e-12 -5.2 -5.2 1.9e-07 0.93 0.05 0.95 FALSE
24 GTEx Nerve Tibial HSD3B7 0.09 0.05 lasso 3 0.03 2.4e-03 -5.4 -5.5 3.0e-08 0.90 0.04 0.85 FALSE
25 GTEx Nerve Tibial RP11-196G11.2 0.17 0.22 lasso 6 0.22 2.3e-15 -5.3 -5.6 2.7e-08 0.95 0.03 0.97 FALSE
26 GTEx Ovary RP11-196G11.2 0.41 0.22 lasso 10 0.25 6.0e-07 -5.4 -5.5 3.1e-08 0.96 0.04 0.96 FALSE
27 GTEx Pancreas STX1B 0.23 0.18 lasso 3 0.16 2.8e-07 -5.2 -5.2 1.9e-07 0.90 0.05 0.95 FALSE
28 GTEx Pancreas RP11-196G11.2 0.13 0.11 lasso 1 0.11 2.5e-05 -5.3 -5.3 1.4e-07 0.91 0.04 0.94 FALSE
29 GTEx Pituitary HSD3B7 0.13 0.07 lasso 7 0.05 2.1e-02 -5.3 -5.4 7.9e-08 0.98 0.05 0.86 FALSE
30 GTEx Pituitary RP11-196G11.2 0.21 0.28 lasso 6 0.23 1.4e-06 -5.5 -5.3 1.1e-07 0.95 0.03 0.96 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic RP11-196G11.2 0.22 0.21 lasso 9 0.26 3.2e-14 -5.5 -5.5 4.8e-08 0.96 0.02 0.98 FALSE
32 GTEx Skin Sun Exposed Lower leg STX1B 0.05 0.04 enet 4 0.05 7.2e-05 -5.2 -5.3 1.1e-07 0.92 0.04 0.95 FALSE
33 GTEx Skin Sun Exposed Lower leg HSD3B7 0.12 0.17 lasso 5 0.16 2.7e-13 -5.1 -5.3 1.2e-07 0.97 0.06 0.94 FALSE
34 GTEx Skin Sun Exposed Lower leg RP11-196G11.2 0.16 0.15 lasso 7 0.15 4.0e-12 -5.4 -5.6 1.9e-08 0.92 0.03 0.97 FALSE
35 GTEx Stomach RP11-196G11.2 0.25 0.16 enet 21 0.14 4.6e-07 -3.8 -5.1 2.7e-07 0.83 0.15 0.84 FALSE
36 GTEx Testis STX1B 0.26 0.23 lasso 5 0.25 1.2e-11 -5.3 -5.4 6.9e-08 0.90 0.04 0.96 FALSE
37 GTEx Testis RP11-196G11.2 0.14 0.11 lasso 4 0.13 3.1e-06 -5.3 -5.4 6.2e-08 0.93 0.03 0.96 FALSE
38 GTEx Thyroid RP11-196G11.2 0.11 0.14 lasso 2 0.14 3.5e-11 -5.4 -5.5 4.3e-08 0.92 0.03 0.97 FALSE
39 GTEx Uterus RP11-196G11.2 0.18 0.16 lasso 20 0.15 5.4e-04 -5.5 -5.4 5.1e-08 0.96 0.04 0.92 FALSE
40 GTEx Whole Blood RP11-196G11.2 0.07 0.05 lasso 3 0.06 1.4e-06 -5.3 -5.2 2.4e-07 0.91 0.05 0.94 FALSE
41 METSIM Adipose RP11-196G11.2 0.13 0.17 lasso 9 0.16 2.2e-23 -5.4 -5.4 5.5e-08 0.88 0.03 0.97 FALSE
42 ROSMAP Brain Pre-frontal Cortex STX1B 0.08 0.10 lasso 7 0.10 3.0e-12 -5.3 -5.3 1.3e-07 0.98 0.04 0.96 FALSE
43 ROSMAP Brain Pre-frontal Cortex HSD3B7 0.03 0.05 lasso 6 0.02 3.0e-04 -5.3 -5.2 2.2e-07 0.90 0.03 0.96 FALSE
44 ROSMAP Brain Pre-frontal Cortex STX4 0.06 0.11 lasso 10 0.11 1.4e-13 -5.3 5.2 1.6e-07 -0.93 0.03 0.96 FALSE
45 ROSMAP Brain Pre-frontal Cortex RP11-196G11.2 0.12 0.12 lasso 4 0.12 1.1e-14 -5.4 -5.4 5.8e-08 0.88 0.03 0.97 FALSE
46 YFS Blood STX4 0.03 0.06 lasso 2 0.05 4.3e-17 -5.4 -5.4 5.6e-08 0.89 0.03 0.97 FALSE
47 The Cancer Genome Atlas Bladder Urothelial Carcinoma HSD3B7 0.04 0.02 enet 13 0.03 2.1e-03 -5.4 -5.6 1.9e-08 0.93 0.02 0.63 FALSE
48 The Cancer Genome Atlas Breast Invasive Carcinoma PRSS53 0.03 0.03 blup 38 0.02 6.8e-06 -5.3 5.2 2.4e-07 -0.86 0.01 0.99 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BCL7C 0.04 0.01 blup 29 0.02 6.9e-03 -5.3 5.6 2.3e-08 -0.86 0.01 0.82 FALSE
50 The Cancer Genome Atlas Liver Hepatocellular Carcinoma HSD3B7 0.08 0.05 blup 31 0.05 1.8e-03 -5.1 -5.1 2.6e-07 0.98 0.02 0.93 FALSE
51 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma STX1B 0.02 0.01 blup 32 0.01 5.5e-02 -5.4 -5.4 8.7e-08 0.95 0.02 0.56 FALSE
52 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HSD3B7 0.09 0.12 blup 31 0.11 4.1e-05 -5.5 -5.5 4.8e-08 0.97 0.02 0.96 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma HSD3B7 0.24 0.27 lasso 6 0.26 2.0e-27 -5.1 -5.2 2.2e-07 0.97 0.04 0.96 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma PRSS53 0.06 0.02 enet 7 0.04 4.7e-05 -5.3 5.3 1.1e-07 -0.89 0.01 0.99 FALSE
55 The Cancer Genome Atlas Prostate Adenocarcinoma STX1B 0.04 0.03 blup 32 0.04 9.5e-05 -5.4 -5.3 1.4e-07 0.96 0.02 0.96 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma HSD3B7 0.20 0.27 lasso 12 0.28 1.8e-27 -5.4 -5.3 1.0e-07 0.98 0.03 0.97 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma PRSS53 0.11 0.04 enet 8 0.05 9.7e-06 -5.4 5.3 1.3e-07 -0.80 0.01 0.98 FALSE