Hub : Genes

PRSS53

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.2210	0.0840	7.9e-04	0.076	NA	0.095	NA	0.111	3.7e-03	NA	1.3e-03	NA	5.5e-04
2	TCGA	Breast Invasive Carcinoma	0.0276	0.0160	1.7e-05	0.025	0.024	0.021	NA	0.022	5.1e-06	6.8e-06	2.9e-05	NA	1.9e-05
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0538	0.0356	1.5e-03	0.013	0.026	0.018	NA	0.025	1.1e-02	6.3e-04	3.5e-03	NA	6.6e-04
4	TCGA	Brain Lower Grade Glioma	0.0655	0.0498	1.4e-04	0.044	0.029	0.039	NA	0.037	9.7e-06	2.5e-04	2.8e-05	NA	4.1e-05
5	TCGA	Liver Hepatocellular Carcinoma	0.2530	0.1330	5.8e-04	0.029	0.056	0.059	NA	0.027	1.6e-02	1.2e-03	9.2e-04	NA	2.0e-02
6	TCGA	Prostate Adenocarcinoma	0.0610	0.0367	3.1e-05	0.021	0.039	0.040	NA	0.036	2.4e-03	6.0e-05	4.7e-05	NA	1.1e-04
7	TCGA	Thyroid Carcinoma	0.1050	0.0610	1.0e-04	0.043	0.048	0.051	NA	0.046	4.6e-05	1.7e-05	9.7e-06	NA	2.6e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.9	1.5	2.7	-0.4	-1.4	-1.7	-0.8	-1.0	-1.4	-1.4
Bipolar Disorder or Schizophrenia	1.3	3.1	5.7	-1.3	-1.6	-2.2	-1.2	-2.4	-1.4	-1.8
Depressed Affect (Nagel 2018)	6.9	14.5	24.2	-0.7	4.7	4.6	3.1	1.3	4.7	4.9
Depression (Nagel 2018)	1.5	2.2	5.7	0.7	2.1	2.4	0.6	0.1	1.9	0.9
Intelligence (Savage-Jansen 2018)	1.2	3.8	8.2	0.0	-1.6	-1.9	-2.2	-1.8	-2.1	-2.9
Neuroticism (Nagel 2018)	9.6	22.7	36.0	-2.9	6.0	5.1	4.5	0.2	6.0	5.6
Schizophrenia (2018)	0.9	1.9	5.2	-1.4	-0.9	-1.5	-0.9	-2.3	-0.8	-1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.6	0.9	0.6	0.5	-0.4	0.8	0.5
Worry (Nagel 2018)	7.9	16.7	29.6	-3.7	5.4	4.0	3.8	-1.4	5.1	4.0
Alzheimer’s Disease (in mother)	5.3	6.2	17.6	-4.2	2.4	0.5	3.4	-1.7	2.1	1.0
Alzheimer’s Disease (in father)	2.9	3.1	5.4	-2.3	2.2	1.1	2.3	-0.8	1.9	1.1
Alzheimer’s Disease (including proxy)	8.7	12.6	27.6	-5.2	4.1	1.8	4.5	-1.6	3.5	2.2
Crohns Disease (2017)	2.1	4.7	7.8	-0.3	2.2	2.7	1.7	2.0	2.4	2.8
Irritable Bowel Disease (IBD)	1.7	4.0	7.2	-0.4	2.0	2.5	1.5	1.8	2.2	2.7
Ulcerative Colitis (UC)	0.3	0.6	1.2	-0.6	0.7	0.9	0.6	0.7	0.9	1.1
Major Depression (MDD)	1.0	1.2	1.7	-1.3	1.1	0.8	1.2	-0.3	1.3	1.3
Reaction Time	0.8	1.5	3.8	0.7	-1.0	-0.9	-1.9	-1.2	-1.3	-1.3
Verbal and Numeric Reasoning (VNR)	1.7	4.0	9.7	1.5	-1.6	-1.2	-3.1	-0.6	-2.2	-2.6
Breast Cancer	1.5	3.7	8.5	2.9	-1.6	-0.8	-1.8	0.6	-2.0	-2.6
Ovarian Cancer	0.6	0.8	3.5	-0.8	-0.4	-0.9	0.0	-1.9	-0.3	-0.5
Prostate Cancer	0.4	0.6	1.2	-1.0	0.3	0.4	1.1	1.0	0.7	0.7
Age at First Birth	0.7	1.1	2.9	-1.7	0.4	-0.5	1.6	-1.0	0.6	0.6
Bipolar Disorder (2011)	2.9	2.8	12.6	0.0	-0.6	-2.1	-0.3	-3.6	-0.6	-1.2
Body Mass Index (BMI) (2010)	2.2	3.0	6.8	2.6	-1.8	-0.7	-1.5	1.4	-1.9	-1.6
Coronary Artery Disease (CAD)	0.2	0.2	1.0	-0.1	0.2	0.2	-1.0	-0.5	0.0	0.3
Crohns Disease (2012)	0.4	0.6	1.1	-0.9	0.8	0.8	0.2	0.6	0.7	1.0
Mean Putamen Volume	0.3	0.3	0.9	-1.0	0.4	-0.1	0.3	-0.2	0.3	1.0
Fasting Glucose	0.4	0.4	1.5	0.8	0.0	0.4	0.6	1.2	0.4	0.3
HbA1C	0.3	0.3	0.8	-0.2	-0.7	-0.9	-0.5	-0.3	-0.9	-0.2
HDL Cholesterol	1.8	3.0	10.4	-3.2	1.4	0.1	1.4	-1.9	1.5	1.0
LDL Cholesterol	1.1	1.8	5.5	2.3	-0.6	0.5	-0.4	2.2	-0.8	-0.8
Lupus	1.4	2.2	5.6	2.4	-0.8	-0.8	-1.6	-2.2	-0.5	-0.8
Neuroticism (2016)	4.0	5.8	8.8	-1.8	2.7	2.3	3.0	0.8	2.9	2.6
Primary Biliary Cirrhosis	1.5	2.1	5.2	2.3	-1.4	-0.6	-2.0	0.9	-1.4	-0.6
Rheumatoid Arthritis	0.3	0.5	1.1	0.4	0.5	0.8	0.1	0.8	0.7	1.1
Schizophrenia (2014)	1.1	2.4	7.2	-1.7	-1.0	-1.8	-0.8	-2.7	-0.8	-1.1
Triglycerides	6.2	10.2	30.0	5.5	-3.0	-0.7	-2.8	3.1	-3.1	-2.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.3	-0.1	-0.4	0.2	-0.7	-0.0	-0.0
Ulcerative Colitis	0.3	0.5	1.4	0.4	0.8	1.2	-0.3	0.7	0.6	0.6
Blood Eosinophil Count	1.7	12.8	38.7	-5.3	-0.4	-3.0	0.3	-6.2	-1.0	-3.6
Blood Platelet Count	0.1	0.8	2.9	0.8	0.3	0.2	-1.1	-0.7	-0.3	-1.7
Blood Red Count	8.4	81.6	130.0	-5.9	10.7	9.4	9.5	2.1	11.4	10.4
Blood White Count	0.8	5.9	22.5	-4.7	1.4	-0.2	3.0	-2.1	1.8	0.6
Heel T-Score	2.0	15.9	50.0	-7.1	3.1	0.4	5.1	-3.1	3.4	2.1
BMI	6.1	35.6	116.6	10.8	-4.6	0.0	-6.9	6.2	-4.6	-2.2
Height	0.2	3.5	11.6	1.4	-3.4	-2.4	-1.0	0.2	-2.0	-0.5
Waist Hip Ratio (WHR)	0.3	1.5	6.3	-2.5	0.1	-0.4	1.1	-1.0	0.7	1.1
Systolic Blood Pressure	0.6	2.9	14.4	1.3	0.1	1.1	0.4	3.8	0.3	1.7
Smoking Status	1.9	4.5	12.1	3.5	-1.7	-0.0	-2.5	2.3	-1.8	-1.4
Allergy or Eczema	1.4	3.7	7.1	-2.7	-1.4	-2.6	0.1	-2.5	-1.2	-1.6
Cardiovascular Disease	5.8	19.1	41.9	6.5	-4.5	-1.7	-5.5	3.1	-4.5	-2.8
Hypothyroidism (self reported)	0.6	1.5	2.6	-0.9	1.3	1.1	1.1	-0.1	1.5	1.6
Respiratory disease	2.2	5.0	8.8	1.5	-2.8	-2.1	-3.0	-0.2	-2.8	-2.0
Type 2 Diabetes (T2D) (2018)	1.6	3.0	9.6	3.1	-1.3	0.4	-1.4	2.6	-1.0	-0.1
Lung FEV1/FVC ratio	0.9	4.8	10.2	-3.2	2.5	1.4	2.3	-1.5	2.4	1.2
Lung FVC	7.3	37.3	56.4	-5.5	7.1	5.5	6.7	0.0	7.5	7.0
Neuroticism	8.2	19.8	31.4	-2.8	5.4	4.6	4.6	0.3	5.6	5.2
Chronotype (morning person)	0.8	1.9	3.1	0.6	1.3	1.6	1.1	1.6	1.4	1.8
Hair Pigment	0.1	1.7	5.2	-2.3	1.2	0.4	1.7	-0.6	1.0	0.8
Tanning	0.1	1.2	5.5	-0.8	-0.3	-0.9	-0.3	-2.4	-0.4	-1.1
Hand grip strength (left)	2.5	6.5	13.6	3.7	-2.8	-1.4	-2.8	1.1	-2.9	-2.1
Number of treatments/medications taken	5.6	10.1	15.1	2.9	-3.9	-2.9	-3.8	-0.2	-3.8	-3.2
Average weekly spirits intake	0.2	0.2	0.5	0.6	-0.5	-0.2	-0.1	0.7	-0.5	-0.2
Sensitivity / hurt feelings	2.3	3.9	6.7	-1.4	2.3	1.8	2.1	-0.3	2.6	2.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.3	0.5	1.3	1.5	-0.1	-0.1	1.1	0.6
Hearing difficulty/problems: Yes	3.0	4.5	7.0	1.8	-2.0	-1.8	-2.6	-0.4	-2.6	-2.6
Relative age of first facial hair	2.0	4.2	8.7	2.6	-2.2	-1.4	-3.0	-0.5	-2.0	-1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	0.9	-0.4	-0.1	-1.3	0.2	-0.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.4	-0.0	0.2	0.4	0.2	1.2	0.3	0.6
Ever had hysterectomy (womb removed)	2.3	2.6	8.6	2.9	-1.0	0.0	-2.2	0.6	-1.1	-1.2
Systolic blood pressure, automated reading	1.5	4.3	15.5	3.1	0.2	1.7	-0.5	3.9	0.2	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.4	-0.6	-0.2	-0.6	0.7	-0.7	-0.8
Angina	1.0	1.3	2.5	1.2	1.0	1.6	-0.1	1.3	0.9	1.2
Medication for hormone replacement therapy	0.2	0.3	0.6	-0.4	-0.4	-0.6	-0.8	-0.4	-0.5	-0.5
Vitamin and mineral supplements	0.5	0.7	4.2	-0.5	0.4	-0.0	0.2	-2.0	0.3	-0.5
Supplements: Zinc	0.5	0.5	1.2	-1.1	0.5	0.3	0.9	0.2	0.7	1.0
Medication: Co-codamol	2.4	2.8	8.8	3.0	-1.1	0.2	-2.0	2.0	-1.1	-0.6
Medication: Metformin	1.0	1.5	2.8	1.5	-1.7	-0.9	-0.9	0.9	-1.3	-1.1
Diabetes (father)	0.7	0.8	2.5	-1.6	-0.1	-0.6	1.6	0.3	0.2	0.6
Diabetes (mother)	1.7	2.2	10.0	3.2	-0.7	0.7	-1.7	1.3	-0.3	-0.0
Severe depression (siblings)	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.0	-0.3	-0.1	0.0
Pack years adult smoking proportion	1.5	2.2	4.7	2.2	-1.5	-0.8	-1.7	0.5	-1.6	-1.6
Impedance of leg (right)	2.6	12.4	39.6	-6.3	-0.3	-3.1	2.5	-5.3	-0.1	-1.7
Leg fat-free mass (left)	3.0	15.8	57.0	7.5	-2.7	0.8	-4.4	4.7	-2.2	-0.1
Trunk fat percentage	6.9	27.8	64.5	8.0	-5.7	-2.3	-6.5	3.0	-5.4	-3.7
Hand grip strength (right)	1.5	4.1	8.2	2.9	-2.4	-1.2	-2.1	1.2	-2.3	-1.5
Townsend deprivation index at recruitment	4.1	5.7	11.0	3.3	-2.4	-0.8	-3.1	1.9	-2.4	-1.9
Current tobacco smoking	1.1	1.8	5.1	2.3	-0.6	0.6	-1.3	2.1	-0.6	0.1
Average weekly fortified wine intake	0.3	0.4	1.1	-0.6	-0.6	-1.1	0.1	-0.4	-0.7	-0.5
Maternal smoking around birth	0.6	0.9	4.0	0.3	0.5	0.9	0.7	2.0	0.4	0.8
Fed-up feelings	3.4	6.2	12.3	-0.3	2.9	3.0	1.9	0.9	3.1	3.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	5.3	1.8	1.4	2.3	-0.3	1.1	1.2	0.8
Relative age voice broke	5.0	7.6	10.6	1.6	-3.2	-2.9	-2.9	-1.6	-3.2	-3.3
Taking other prescription medications	1.1	1.7	3.2	1.0	-1.8	-1.2	-1.6	0.1	-1.5	-1.3
Age when periods started (menarche)	1.1	2.6	11.1	-1.8	-0.7	-1.6	-0.6	-3.3	-0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	1.0	-0.3	0.1	-0.8	0.4	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.9	-1.7	0.9	0.5	1.4	-0.4	1.2	0.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.3	0.6	-1.2	-1.0	-1.5	-1.2	-1.0	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	1.2	1.1	-0.4	0.1	-1.0	0.3	-0.1	0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.0	1.0	0.1	0.8	-0.8	1.0	0.1	0.5
High blood pressure	4.2	11.8	33.0	5.7	-3.2	-0.6	-4.4	3.0	-3.0	-1.2
Hayfever, allergic rhinitis or eczema	1.3	2.9	7.8	-2.8	-1.0	-2.0	0.3	-2.4	-0.7	-1.0
Multivitamins +/- minerals	0.2	0.2	1.2	-0.1	-0.2	-0.0	0.2	1.1	-0.0	0.3
Stomach or abdominal pain in last month	0.0	0.1	0.1	-0.4	0.1	0.1	-0.3	0.0	-0.1	-0.3
Supplements: Glucosamine	0.4	0.6	1.7	-1.3	0.0	-0.6	1.0	-0.7	-0.0	-0.7
Diverticular disease/diverticulitis (self-reported)	2.4	2.9	5.8	0.3	1.8	2.2	1.1	0.6	2.1	2.4
Medication: Atenolol	1.1	1.4	2.9	1.4	1.0	1.7	0.3	1.3	1.0	0.9
Medication: Levothyroxine sodium	0.1	0.1	0.4	-0.2	0.2	0.2	0.2	-0.1	0.4	0.6
Sitting height	0.6	4.0	6.5	0.0	2.2	2.5	1.8	1.6	2.4	2.3
Chronic bronchitis/emphysema (father)	5.6	6.6	13.4	2.0	-2.7	-2.0	-3.7	-0.6	-3.1	-2.7
High blood pressure (mother)	1.0	1.4	5.1	2.3	-0.2	0.8	-1.0	1.7	-0.0	0.6
Body mass index (BMI)	7.5	32.1	107.4	10.4	-4.2	0.2	-6.4	6.0	-4.2	-2.0
Impedance of leg (left)	2.2	10.6	35.0	-5.9	-0.1	-2.7	2.6	-4.8	0.1	-1.3
Leg predicted mass (left)	3.0	15.7	56.9	7.5	-2.7	0.7	-4.3	4.7	-2.2	-0.1
Trunk fat mass	6.8	29.2	78.7	8.9	-5.4	-1.7	-6.6	3.9	-5.1	-3.0
Waist circumference	9.4	34.6	96.8	9.8	-5.6	-1.3	-7.1	5.0	-5.3	-2.9
Number of incorrect matches in round	6.1	10.2	29.8	-5.5	2.7	0.2	3.4	-3.4	2.8	1.9
Past tobacco smoking	1.5	2.8	6.7	-2.6	1.5	0.3	1.8	-1.5	1.6	1.6
Alcohol usually taken with meals	0.4	0.7	2.5	-1.0	-0.2	-1.0	-0.3	-1.6	-0.3	-0.6
Nervous feelings	5.8	10.9	19.2	-3.9	4.4	2.6	3.2	-1.8	3.7	2.8
Frequency of tenseness / restlessness in last 2 weeks	4.0	6.2	11.6	-1.1	3.4	3.2	1.5	0.5	3.2	2.8
Hearing difficulty/problems with background noise	0.9	1.4	2.5	0.1	-1.4	-1.5	-1.1	-0.3	-1.6	-1.4
Hair/balding pattern: Pattern 2	0.2	0.2	1.1	-1.0	0.2	-0.2	0.4	-0.1	-0.2	0.0
Had menopause	2.9	3.6	5.6	1.8	-2.1	-1.6	-2.4	-0.6	-2.2	-2.0
Had other major operations	1.4	1.7	4.9	2.2	-1.0	0.1	-1.7	1.5	-0.9	0.3
Forced vital capacity (FVC)	6.1	23.4	39.4	-4.2	5.1	3.9	5.5	-0.3	5.9	6.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	7.0	-2.7	1.2	0.4	2.1	-0.9	1.8	1.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.1	0.2	1.4	1.8	0.4	0.5	1.6	1.6
Qualifications: None of the above	0.9	1.9	6.3	1.9	0.4	1.4	-0.1	2.5	0.3	0.8
Financial difficulties in last 2 years	4.5	6.0	18.9	4.4	-1.8	0.4	-3.6	1.9	-1.7	-0.8
Mouth/teeth dental problems	0.8	1.2	4.1	-2.0	0.3	-0.6	1.3	-1.5	0.4	0.2
Heart attack	0.9	1.1	3.0	0.8	-1.1	-0.8	-1.1	-0.4	-1.0	-1.7
Allergy	2.6	5.9	10.6	1.5	2.5	3.2	1.5	2.8	2.4	2.5
Pain all over the body in last month	3.5	3.8	6.9	1.9	-2.2	-1.5	-2.6	0.1	-2.2	-2.0
Diabetes (self-reported)	1.9	2.9	5.0	2.2	-2.0	-0.7	-1.4	2.2	-1.7	-1.0
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	8.8	-3.0	-0.3	-1.5	0.9	-2.4	-0.1	-0.4
Medication: Ramipril	2.3	3.0	10.5	3.2	-1.3	-0.2	-2.0	0.7	-1.4	-1.4
Medication: Simvastatin	4.1	6.0	12.2	3.5	-2.4	-1.1	-2.9	0.8	-2.6	-2.6
Fluid intelligence score	3.0	6.2	13.5	2.4	-2.0	-1.4	-3.7	-0.4	-2.8	-3.1
Illnesses of siblings	6.7	9.4	25.1	-5.0	2.5	0.5	3.6	-2.9	2.9	1.9
Neuroticism score	8.7	18.1	28.2	-2.2	5.2	4.6	4.1	1.0	5.3	5.3
Weight	6.3	31.2	99.4	10.0	-4.9	-0.5	-6.5	5.3	-4.4	-1.9
Impedance of arm (right)	2.9	13.3	38.6	-6.1	-0.6	-3.4	1.8	-6.2	-0.2	-1.4
Arm fat percentage (right)	7.3	28.9	83.5	9.1	-5.0	-1.2	-6.6	3.9	-4.9	-3.0
Trunk fat-free mass	1.8	10.5	37.6	6.1	-1.3	1.7	-2.6	4.8	-0.8	1.1
Hip circumference	10.1	43.4	123.2	11.1	-6.2	-1.6	-7.9	5.2	-6.0	-3.7
Time employed in main current job	0.2	0.2	0.6	-0.2	-0.8	-0.8	-0.3	-0.1	-0.4	0.3
Alcohol intake versus 10 years previously	1.9	2.8	4.7	0.4	-2.1	-1.9	-1.9	-0.4	-2.2	-1.8
Father’s age at death	1.6	2.1	5.3	-2.3	1.1	0.3	2.1	-0.7	1.4	1.1
Worrier / anxious feelings	8.3	15.7	28.1	-1.7	5.3	4.8	3.3	0.3	5.1	4.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.6	1.6	0.5	1.4	-1.6	1.6	0.2	1.1
Falls in the last year	3.2	4.3	9.6	3.0	-2.0	-0.7	-3.1	1.1	-2.0	-1.4
Hair/balding pattern: Pattern 3	3.8	5.7	8.4	1.7	-2.7	-2.4	-2.4	-1.7	-2.6	-2.9
Number of live births	0.5	0.8	1.4	1.0	0.8	1.2	-0.1	0.5	0.9	1.1
Forced expiratory volume in 1-second (FEV1)	7.2	24.3	36.7	-4.4	5.5	4.2	5.6	-0.2	6.1	6.0
Pulse rate	0.5	0.8	2.1	-0.3	-1.3	-1.5	-0.5	-0.4	-1.0	-0.3
Happiness	1.4	1.7	2.9	-1.7	1.3	0.6	1.0	-1.5	1.5	1.1
Noisy workplace	0.9	1.1	1.9	0.0	1.0	1.2	0.8	1.1	1.1	1.4
Qualifications: A levels/AS levels or equivalent	3.1	6.9	16.9	-3.1	-1.5	-3.2	-0.4	-4.1	-1.6	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.5	0.2	0.1	0.2	-0.2	0.3	0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	1.9	1.1	0.6	1.1	-0.3	1.4	0.5	0.7
Asthma	4.6	9.0	12.7	0.9	-3.5	-3.4	-3.5	-2.1	-3.6	-3.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.2	1.1	-0.9	-0.7	-1.5	-0.6	-1.1	-0.9
Medication: Cholesterol lowering	6.0	9.3	16.6	4.1	-3.1	-1.6	-3.6	0.9	-3.4	-3.3
Depression (self-reported)	0.6	0.7	1.8	0.4	0.9	1.1	0.7	1.4	0.6	0.6
Medication: Lansoprazole	0.5	0.6	2.2	1.5	-0.3	0.1	-0.7	0.6	-0.6	-0.9
Prospective memory result	1.9	2.4	5.4	-1.3	1.3	1.3	1.5	1.0	1.7	2.3
Lung cancer (father)	0.6	0.7	2.2	-0.1	0.3	0.4	-1.1	-1.5	0.5	1.0
Illnesses of mother	1.1	1.4	4.3	-2.1	1.0	0.4	1.1	-0.8	1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	7.3	23.3	35.3	-5.1	5.2	3.6	5.5	-1.5	5.9	5.4
Pulse wave Arterial Stiffness index	2.2	2.5	9.2	3.0	-1.2	0.2	-1.7	1.8	-1.0	-0.2
Impedance of arm (left)	2.9	13.3	38.8	-6.0	-0.8	-3.5	1.6	-6.2	-0.4	-1.6
Arm fat mass (right)	7.5	30.7	97.0	9.8	-4.8	-0.6	-6.5	5.2	-4.5	-2.1
Trunk predicted mass	1.8	10.3	36.8	6.1	-1.3	1.7	-2.6	4.7	-0.8	1.1
Standing height	0.1	1.0	2.7	-0.4	-1.6	-1.5	-0.3	-1.2	-0.6	0.4
Length of working week for main job	0.1	0.1	0.4	-0.2	0.4	0.2	0.6	0.2	0.4	0.3
Exposure to tobacco smoke at home	0.8	0.9	2.3	1.5	-1.0	-0.5	-1.2	0.0	-0.9	-0.6
Breastfed as a baby	5.1	6.3	10.6	0.7	-3.3	-3.0	-2.4	-1.5	-2.9	-2.8
Tense / ‘highly strung’	9.6	15.9	24.8	-3.5	5.0	3.7	4.3	-0.4	4.8	4.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.7	-0.8	2.2	2.0	1.5	0.3	2.1	2.1
Hair/balding pattern: Pattern 4	0.6	1.6	2.7	0.1	1.3	1.6	1.0	1.5	1.4	1.3
Birth weight of first child	3.6	6.6	11.3	1.6	-3.4	-2.7	-3.0	-0.2	-3.2	-2.5
Peak expiratory flow (PEF)	2.1	4.8	7.4	-0.7	2.3	2.4	2.4	1.1	2.7	2.7
Pulse wave reflection index	1.4	1.7	5.9	2.4	0.1	1.3	-0.8	1.9	0.2	0.3
Ever highly irritable/argumentative for 2 days	2.2	2.6	4.3	-1.2	1.8	1.6	1.7	0.3	2.1	2.0
Loud music exposure frequency	0.9	1.0	2.8	1.7	0.1	0.6	-1.6	0.2	-0.5	-1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.0	-1.2	-1.1	-1.7	-0.6	-1.7	-1.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	0.9	-0.8	-0.5	-1.0	0.1	-0.7	-0.3
Blood clot in the leg (DVT)	1.5	2.0	4.3	0.9	-0.9	-1.0	-1.6	-1.2	-1.6	-2.1
Medication: Paracetamol	2.6	4.2	9.9	3.0	-1.8	-0.6	-3.1	0.6	-2.0	-1.5
Headache pain in last month	1.5	2.5	6.5	2.2	-1.2	-0.4	-2.6	0.7	-1.7	-1.2
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	12.4	-3.5	1.8	0.4	2.2	-1.9	1.9	1.7
Glaucoma (self-reported)	1.5	1.8	3.0	-1.4	1.4	0.9	1.7	-0.1	1.5	1.6
Gout (self-reported)	0.6	0.8	3.0	-1.7	0.0	-0.8	0.4	-1.3	-0.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.7	0.5	0.4	0.6	-0.1	0.7	0.8
Medication: Amlodipine	0.5	0.7	1.0	0.1	0.7	1.0	0.9	0.8	0.9	0.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.5	0.4	-1.5	-1.6	-0.9	-0.8	-1.4	-0.8
Birth weight	0.9	2.0	8.2	2.9	-0.6	0.6	-1.6	1.4	-0.6	-0.4
Chronic bronchitis/emphysema (mother)	5.6	6.5	10.3	1.6	-2.9	-2.4	-2.9	-0.8	-3.1	-3.2
High blood pressure (siblings)	7.0	10.1	22.9	4.8	-3.1	-1.0	-3.9	2.9	-3.2	-1.9
Forced vital capacity (FVC), Best measure	5.5	20.2	31.5	-4.4	4.7	3.4	4.9	-1.3	5.6	5.5
Body fat percentage	7.7	30.3	74.3	8.6	-5.7	-2.1	-6.7	3.4	-5.5	-3.8
Leg fat percentage (right)	7.0	25.3	62.9	7.9	-5.0	-1.8	-6.0	3.4	-5.1	-3.6
Arm fat-free mass (right)	3.1	15.8	55.1	7.4	-2.5	1.0	-3.8	5.5	-2.0	0.1
Exposure to tobacco smoke outside home	1.8	2.4	6.8	2.6	-1.1	0.2	-1.8	2.0	-1.2	-0.7
Comparative body size at age 10	5.5	15.2	23.6	3.8	-4.8	-3.4	-4.5	0.8	-4.9	-3.6
Number of full brothers	2.1	2.7	7.9	2.8	-0.7	0.6	-1.6	2.6	-0.7	-0.1
Worry too long after embarrassment	1.6	2.8	4.3	-1.4	1.7	1.4	2.1	-0.0	2.0	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.0	-1.1	1.4	1.1	1.1	0.1	1.3	1.4
Wheeze or whistling in the chest in last year	5.6	10.0	20.7	4.0	-3.2	-1.9	-4.6	0.1	-3.6	-2.6
Number of children fathered	0.2	0.2	0.5	0.7	0.6	0.6	-0.1	0.2	0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.9	-0.7	0.4	0.0	1.4	0.2	0.4	0.4
Age at first live birth	1.5	2.7	8.3	-2.9	0.8	-0.5	1.8	-2.3	1.1	0.5
Pulse wave peak to peak time	2.1	2.5	9.3	-3.0	1.1	-0.4	1.6	-1.9	0.9	0.2
Health satisfaction	2.1	2.7	9.0	2.6	0.5	1.6	-0.3	3.0	0.3	0.5
Shortness of breath walking on level ground	1.1	1.3	4.0	2.0	0.5	1.3	-1.5	1.1	-0.1	0.1
Qualifications: College or University degree	1.8	5.7	17.0	-3.9	-0.1	-2.0	1.1	-4.1	-0.0	-1.7
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.6	-0.1	0.2	-0.5	-0.2	-0.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.5	1.7	5.5	2.1	-0.9	0.3	-0.9	2.4	-0.4	0.5
Emphysema/chronic bronchitis	2.1	2.3	3.9	2.0	-1.9	-1.1	-2.0	0.2	-1.6	-1.1
Medication for pain relief, constipation, heartburn	3.6	6.2	11.3	-2.4	2.6	1.8	3.4	0.8	2.8	2.9
Neck or shoulder pain in last month	1.7	2.5	6.9	2.6	-1.4	-0.2	-2.4	1.0	-1.2	-0.4
Medication: Blood pressure	1.5	2.6	8.8	3.0	-0.6	0.8	-0.6	2.8	-0.3	0.2
Angina (self-reported)	0.9	1.2	2.4	1.2	1.0	1.6	-0.1	1.3	0.9	1.1
Migraine (self-reported)	0.3	0.4	2.3	0.2	0.2	0.5	-0.1	1.5	-0.0	0.1
Medication: Ibuprofen	0.9	1.1	1.8	0.9	-1.0	-0.8	-1.3	-1.1	-1.1	-1.0
Medication: Allopurinol	1.1	1.5	6.4	-2.5	0.5	-0.5	0.8	-1.6	0.4	-0.2
Medication: Omeprazole	0.2	0.2	0.5	-0.3	-0.7	-0.6	-0.4	-0.0	-0.4	0.1
Medication: Seretide 50 evohaler	1.0	1.1	2.1	-0.3	-1.0	-1.2	-0.9	-0.9	-1.2	-1.4
Mean time to correctly identify matches	0.6	1.1	2.6	0.3	-0.8	-0.9	-1.6	-1.2	-1.1	-1.2
Heart disease (mother)	0.6	0.7	1.7	0.3	0.8	1.0	0.9	1.3	0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	3.6	1.9	-1.5	-0.9	-1.5	0.6	-1.7	-1.9
Whole body fat mass	7.2	30.1	85.2	9.2	-5.2	-1.3	-6.6	4.5	-5.0	-2.8
Leg fat mass (right)	7.6	29.5	84.5	9.2	-5.1	-1.2	-6.4	4.6	-4.9	-2.9
Arm predicted mass (right)	3.2	16.2	55.5	7.5	-2.7	0.8	-3.9	5.5	-2.2	-0.0
Pulse rate, automated reading	2.6	8.3	16.3	1.7	-4.0	-3.4	-3.2	-0.0	-3.7	-2.0
Alcohol intake frequency.	3.9	9.0	32.0	5.7	-1.7	0.9	-3.7	3.5	-1.4	0.3
Comparative height size at age 10	0.1	0.4	1.4	0.2	-1.2	-0.6	-0.1	0.9	-0.5	0.2
Number of full sisters	4.6	5.6	9.5	1.8	-3.0	-2.2	-3.1	0.5	-3.0	-1.8
Suffer from ‘nerves’	3.2	5.0	10.7	-2.0	3.3	2.3	1.4	-1.5	2.8	1.6
Overall health rating	5.9	12.6	37.9	6.2	-2.6	0.2	-5.0	3.1	-2.7	-1.4
Chest pain or discomfort	1.8	2.6	6.4	2.5	-1.3	-0.3	-2.2	1.0	-1.7	-1.2
Had major operations	1.0	1.2	2.7	1.6	-1.1	-0.2	-1.2	1.3	-0.9	-0.9
Age at last live birth	0.7	1.0	2.5	-1.6	0.8	0.1	0.5	-1.6	0.9	0.5
Family relationship satisfaction	2.2	2.8	4.2	0.2	-1.9	-2.0	-1.5	-1.7	-1.8	-1.8
Leg pain on walking	4.3	5.4	9.7	0.8	2.1	2.7	1.7	3.1	2.2	2.9
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.1	1.3	0.9	1.8	0.4	2.0	1.3	1.7
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.3	0.4	1.3	1.7	1.6	2.3	1.2	1.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.1	-1.3	-0.8	-1.8	0.1	-1.5	-1.1	-1.4
Medication: Aspirin	2.2	2.9	5.9	2.2	-1.7	-0.9	-1.4	0.6	-1.9	-2.4
Supplements: Vitamin C	0.2	0.2	1.3	-1.1	0.1	-0.2	0.3	0.3	0.2	0.2
Knee pain experienced in last month	6.6	10.2	23.1	4.8	-3.0	-1.2	-4.2	0.9	-3.4	-2.9
Hypertension (Self-reported)	4.5	12.5	32.0	5.7	-3.6	-1.1	-4.6	2.7	-3.3	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.5	-1.6	0.2	-0.2	1.4	0.1	0.5	0.9
Illnesses of father: Heart disease	0.2	0.3	0.8	0.2	-0.4	-0.2	-0.6	0.3	-0.7	-0.9
Illnesses of siblings: Diabetes	1.2	1.5	4.5	2.1	-0.8	0.2	-1.6	1.2	-0.8	-0.7
Smoking status: Previous	1.5	2.2	4.4	2.1	-1.4	-0.5	-1.7	0.8	-1.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-0.4	0.7	0.6	0.5	-0.7	1.0	0.8
Whole body fat-free mass	2.4	13.8	50.0	7.1	-2.0	1.4	-3.5	5.1	-1.4	0.7
Leg fat-free mass (right)	2.8	15.0	55.4	7.4	-2.3	1.1	-4.1	4.8	-1.8	0.4
Arm fat percentage (left)	7.3	29.3	83.4	9.1	-5.2	-1.3	-6.7	4.0	-4.9	-3.0
Average weekly red wine intake	0.1	0.1	0.3	-0.6	0.5	0.1	0.3	-0.4	0.3	-0.3
Handedness (chirality/laterality): Left-handed	1.9	2.3	4.2	0.9	-1.8	-1.5	-1.7	0.5	-2.0	-1.5
Mood swings	5.8	10.5	17.2	-0.7	3.8	3.8	2.9	1.7	3.9	4.1
Loneliness, isolation	5.5	7.6	14.9	1.1	3.0	3.9	1.3	2.3	3.0	3.4
Long-standing illness, disability or infirmity	2.3	3.6	8.0	1.6	-1.9	-1.5	-2.8	-0.1	-2.3	-1.9
Ever had bowel cancer screening	0.1	0.2	0.4	0.6	0.4	0.5	-0.1	0.6	0.1	0.0
Diabetes diagnosed by doctor	2.1	3.5	6.5	2.6	-2.1	-0.7	-1.9	2.0	-1.9	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.3	-0.8	1.0	0.9	0.9	0.4	1.1	0.9
Friendships satisfaction	0.4	0.5	2.0	-1.4	0.2	-0.4	0.5	-1.1	0.2	0.1
Qualifications: nursing, teaching	1.2	1.9	4.8	-2.2	-0.8	-1.6	0.1	-1.8	-0.6	-1.3
Commuting to job workplace: Walk	0.8	0.9	2.9	-1.7	-0.1	-0.7	0.1	-1.5	0.3	0.8
Eye problems/disorders: Cataract	0.3	0.4	0.9	0.4	-0.8	-0.6	-1.0	-0.3	-0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.8	2.2	-1.0	-0.2	-2.0	0.5	-1.3	-1.7
Medication for cholesterol	6.6	10.0	19.3	-3.6	3.5	2.1	4.4	-1.1	3.6	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.1	0.1	0.8	1.4	0.1	2.3	0.8	1.5
Back pain experienced in last month	1.0	1.4	4.8	0.8	-1.3	-0.8	-2.2	-0.1	-1.3	-0.6
Mineral and other dietary supplements	0.3	0.4	1.8	1.4	-0.1	0.4	-0.8	-0.4	0.0	-0.3
Breast cancer (self-reported)	0.2	0.3	0.8	-0.7	-0.2	-0.7	0.1	-0.9	-0.3	0.1
Asthma (self-reported)	4.3	8.5	11.4	0.9	-3.3	-3.2	-3.3	-2.3	-3.4	-3.1
Osteoporosis (self-reported)	1.8	2.2	3.5	1.9	-1.6	-1.1	-1.6	-0.7	-1.3	-1.8
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.0	-0.6	-0.6	-0.4	-0.0	-0.6	0.0
Medication: Aspirin	1.2	1.5	4.3	2.1	-1.0	-0.3	-0.7	0.8	-1.1	-1.7
Medication: Gliclazide	0.6	0.7	3.2	0.6	-0.8	-0.2	0.3	1.8	-0.4	0.4
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	-0.9	1.1	0.8	1.2	-1.0	1.6	1.7
Smoking status: Current	0.7	1.2	3.6	1.8	-0.3	0.7	-0.9	1.9	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	12.0	25.4	37.7	-6.1	5.7	3.5	5.7	-1.8	5.9	5.0
Whole body water mass	2.4	13.6	49.1	7.0	-2.0	1.4	-3.4	5.1	-1.4	0.6
Leg predicted mass (right)	2.8	14.8	54.6	7.4	-2.4	1.0	-4.1	4.7	-1.9	0.3
Arm fat mass (left)	7.8	32.1	98.2	9.9	-5.1	-0.8	-6.7	5.1	-4.8	-2.4
Number of self-reported non-cancer illnesses	4.0	7.0	11.1	2.9	-3.0	-2.0	-3.3	0.3	-3.1	-2.6
Average weekly champagne plus white wine intake	0.3	0.4	1.0	1.0	0.0	0.2	-1.0	0.0	-0.4	-0.6
Miserableness	2.4	4.1	7.7	-0.0	2.8	2.7	1.3	0.1	2.6	2.3
Guilty feelings	3.1	4.6	9.1	-0.3	2.4	2.6	1.7	1.3	2.5	3.0
Wears glasses or contact lenses	0.5	0.6	2.0	0.7	-0.5	-0.2	-0.8	1.4	-0.5	0.5
Ever taken oral contraceptive pill	0.3	0.4	1.6	0.4	0.3	0.6	0.3	1.3	0.3	0.6
Hearing aid user	1.2	1.3	5.0	2.2	0.1	0.8	-0.8	1.7	-0.4	-0.1
Mother’s age at death	0.1	0.1	0.3	-0.6	-0.0	-0.4	-0.1	-0.4	-0.3	-0.3
Financial situation satisfaction	0.7	0.8	2.5	1.6	0.1	0.9	-0.3	1.6	-0.0	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.6	1.6	0.1	0.6	-0.1	1.4	0.0	0.2
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.9	-0.7	-0.5	-0.7	-0.4	-0.6	-0.5
Eye problems/disorders: Glaucoma	1.8	2.2	5.7	-1.8	1.3	0.6	2.4	0.0	1.4	1.4
Medication: Blood pressure	3.6	6.9	15.1	3.9	-2.8	-1.2	-3.5	1.8	-2.6	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.9	1.3	-0.6	0.1	-1.4	0.6	-0.5	0.4
Supplements: Fish oil (including cod liver oil)	1.8	2.4	3.7	-1.5	1.8	1.2	1.9	1.0	1.4	1.8
High cholesterol (Self-reported)	5.8	10.3	14.2	3.8	-3.5	-2.1	-3.5	1.2	-3.8	-3.7
Medication: Bendroflumethiazide	3.5	5.3	15.6	4.0	-2.3	-0.7	-2.8	2.0	-1.9	-0.4
Medication: Paracetamol	2.1	3.3	8.9	2.9	-1.3	-0.2	-3.0	0.4	-1.6	-1.2
Medication: Lisinopril	1.2	1.6	5.9	1.3	-1.4	-0.7	-0.1	2.4	-1.0	0.0
Medication: Atorvastatin	5.2	6.4	9.9	3.1	-2.8	-1.7	-3.0	0.3	-2.8	-2.8
Illnesses of father: High blood pressure	1.7	2.1	5.2	2.3	-0.7	0.4	-1.7	2.2	-1.0	-0.4
Alcohol drinker status: Never	0.1	0.2	0.3	0.6	0.4	0.5	-0.2	-0.2	0.3	0.5
Ever smoked	0.9	1.6	4.1	2.0	-0.8	0.3	-1.3	1.8	-0.9	-0.7
Basal metabolic rate	3.2	17.9	63.8	8.0	-2.8	1.0	-4.3	5.4	-2.2	0.1
Leg fat percentage (left)	7.2	26.1	68.9	8.3	-4.9	-1.6	-6.2	3.6	-5.0	-3.3
Arm fat-free mass (left)	3.5	17.6	61.3	7.8	-2.5	1.1	-4.1	5.8	-2.1	0.2
Number of operations (self-reported)	1.3	2.0	5.2	2.3	-1.3	0.1	-1.4	2.0	-1.0	-0.3
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.7	0.6	0.3	0.4	-0.6	0.3	-0.2
Irritability	10.3	17.4	26.5	-2.8	4.6	4.1	4.7	1.5	5.1	5.1
Risk taking	0.7	1.0	2.2	0.9	-0.9	-0.6	-1.0	0.3	-1.3	-1.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.1	0.6	0.6	0.1	0.1	0.5	0.7
Fractured/broken bones in last 5 years	4.9	6.3	14.6	3.8	-2.2	-0.8	-3.6	0.6	-2.4	-2.2
Age started oral contraceptive pill	0.4	0.5	0.9	0.1	-0.9	-0.9	-0.6	-0.8	-0.8	-0.7
Diastolic blood pressure, automated reading	4.6	14.1	39.2	6.3	-3.8	-1.3	-4.9	2.2	-3.5	-1.5
Ever depressed for a whole week	2.1	2.6	4.4	-1.0	1.8	1.6	1.7	0.2	2.1	2.0
Unable to work because of sickness or disability	3.8	4.9	16.0	4.0	-1.3	0.6	-3.0	2.3	-1.3	-0.5
Commuting to job workplace: Cycle	0.8	1.0	2.5	-0.7	-0.9	-1.3	-0.1	-1.0	-0.8	-1.6
Myopia	4.5	6.5	10.9	2.0	-2.7	-2.2	-3.3	-0.9	-3.1	-2.9
Vascular/heart problems diagnosed by doctor	4.6	12.6	37.7	-6.1	3.2	0.5	4.6	-2.9	3.0	1.4
Cholesterol lowering medication	8.8	13.0	23.1	4.6	-3.6	-2.0	-4.8	0.4	-3.9	-3.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-0.4	-0.9	-1.0	-0.9	-0.8	-0.8	-0.5
Pain experienced in last month	7.3	12.2	24.8	-3.8	3.7	2.3	5.0	-0.2	4.0	3.3
Supplements: Calcium	0.2	0.2	0.4	-0.0	-0.6	-0.5	-0.6	0.3	-0.5	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-1.2	0.5	0.2	1.2	0.4	0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.9	0.9	-1.0	-0.7	-1.1	-0.5	-1.0	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.2	0.9	-0.9	-1.0	-1.6	-1.1	-1.6	-2.0
Heart disease (siblings)	2.8	3.5	10.9	2.7	0.7	2.0	-0.5	3.3	0.4	1.0
Alcohol drinker status: Previous	1.7	1.9	7.2	2.7	-0.0	1.1	-1.1	1.9	-0.1	0.2
Pack years of smoking	1.9	2.8	4.6	2.1	-1.8	-1.1	-1.8	0.5	-1.9	-1.9
Impedance of whole body	2.9	14.9	44.5	-6.7	-0.6	-3.6	2.3	-6.2	-0.3	-1.7
Leg fat mass (left)	7.7	30.0	86.5	9.3	-5.1	-1.2	-6.5	4.6	-4.9	-2.8
Arm predicted mass (left)	3.6	18.4	64.2	8.0	-2.8	0.9	-4.2	5.7	-2.3	-0.2