Hub : Genes

PRSS53

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Liver 0.2210 0.0840 7.9e-04 0.076 NA 0.095 NA 0.111 3.7e-03 NA 1.3e-03 NA 5.5e-04
2 TCGA Breast Invasive Carcinoma 0.0276 0.0160 1.7e-05 0.025 0.024 0.021 NA 0.022 5.1e-06 6.8e-06 2.9e-05 NA 1.9e-05
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0538 0.0356 1.5e-03 0.013 0.026 0.018 NA 0.025 1.1e-02 6.3e-04 3.5e-03 NA 6.6e-04
4 TCGA Brain Lower Grade Glioma 0.0655 0.0498 1.4e-04 0.044 0.029 0.039 NA 0.037 9.7e-06 2.5e-04 2.8e-05 NA 4.1e-05
5 TCGA Liver Hepatocellular Carcinoma 0.2530 0.1330 5.8e-04 0.029 0.056 0.059 NA 0.027 1.6e-02 1.2e-03 9.2e-04 NA 2.0e-02
6 TCGA Prostate Adenocarcinoma 0.0610 0.0367 3.1e-05 0.021 0.039 0.040 NA 0.036 2.4e-03 6.0e-05 4.7e-05 NA 1.1e-04
7 TCGA Thyroid Carcinoma 0.1050 0.0610 1.0e-04 0.043 0.048 0.051 NA 0.046 4.6e-05 1.7e-05 9.7e-06 NA 2.6e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.9 1.5 2.7 -0.4 -1.4 -1.7 -0.8 -1.0 -1.4 -1.4
Bipolar Disorder or Schizophrenia 1.3 3.1 5.7 -1.3 -1.6 -2.2 -1.2 -2.4 -1.4 -1.8
Depressed Affect (Nagel 2018) 6.9 14.5 24.2 -0.7 4.7 4.6 3.1 1.3 4.7 4.9
Depression (Nagel 2018) 1.5 2.2 5.7 0.7 2.1 2.4 0.6 0.1 1.9 0.9
Intelligence (Savage-Jansen 2018) 1.2 3.8 8.2 0.0 -1.6 -1.9 -2.2 -1.8 -2.1 -2.9
Neuroticism (Nagel 2018) 9.6 22.7 36.0 -2.9 6.0 5.1 4.5 0.2 6.0 5.6
Schizophrenia (2018) 0.9 1.9 5.2 -1.4 -0.9 -1.5 -0.9 -2.3 -0.8 -1.1
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 -0.6 0.9 0.6 0.5 -0.4 0.8 0.5
Worry (Nagel 2018) 7.9 16.7 29.6 -3.7 5.4 4.0 3.8 -1.4 5.1 4.0
Alzheimer’s Disease (in mother) 5.3 6.2 17.6 -4.2 2.4 0.5 3.4 -1.7 2.1 1.0
Alzheimer’s Disease (in father) 2.9 3.1 5.4 -2.3 2.2 1.1 2.3 -0.8 1.9 1.1
Alzheimer’s Disease (including proxy) 8.7 12.6 27.6 -5.2 4.1 1.8 4.5 -1.6 3.5 2.2
Crohns Disease (2017) 2.1 4.7 7.8 -0.3 2.2 2.7 1.7 2.0 2.4 2.8
Irritable Bowel Disease (IBD) 1.7 4.0 7.2 -0.4 2.0 2.5 1.5 1.8 2.2 2.7
Ulcerative Colitis (UC) 0.3 0.6 1.2 -0.6 0.7 0.9 0.6 0.7 0.9 1.1
Major Depression (MDD) 1.0 1.2 1.7 -1.3 1.1 0.8 1.2 -0.3 1.3 1.3
Reaction Time 0.8 1.5 3.8 0.7 -1.0 -0.9 -1.9 -1.2 -1.3 -1.3
Verbal and Numeric Reasoning (VNR) 1.7 4.0 9.7 1.5 -1.6 -1.2 -3.1 -0.6 -2.2 -2.6
Breast Cancer 1.5 3.7 8.5 2.9 -1.6 -0.8 -1.8 0.6 -2.0 -2.6
Ovarian Cancer 0.6 0.8 3.5 -0.8 -0.4 -0.9 0.0 -1.9 -0.3 -0.5
Prostate Cancer 0.4 0.6 1.2 -1.0 0.3 0.4 1.1 1.0 0.7 0.7
Age at First Birth 0.7 1.1 2.9 -1.7 0.4 -0.5 1.6 -1.0 0.6 0.6
Bipolar Disorder (2011) 2.9 2.8 12.6 0.0 -0.6 -2.1 -0.3 -3.6 -0.6 -1.2
Body Mass Index (BMI) (2010) 2.2 3.0 6.8 2.6 -1.8 -0.7 -1.5 1.4 -1.9 -1.6
Coronary Artery Disease (CAD) 0.2 0.2 1.0 -0.1 0.2 0.2 -1.0 -0.5 0.0 0.3
Crohns Disease (2012) 0.4 0.6 1.1 -0.9 0.8 0.8 0.2 0.6 0.7 1.0
Mean Putamen Volume 0.3 0.3 0.9 -1.0 0.4 -0.1 0.3 -0.2 0.3 1.0
Fasting Glucose 0.4 0.4 1.5 0.8 0.0 0.4 0.6 1.2 0.4 0.3
HbA1C 0.3 0.3 0.8 -0.2 -0.7 -0.9 -0.5 -0.3 -0.9 -0.2
HDL Cholesterol 1.8 3.0 10.4 -3.2 1.4 0.1 1.4 -1.9 1.5 1.0
LDL Cholesterol 1.1 1.8 5.5 2.3 -0.6 0.5 -0.4 2.2 -0.8 -0.8
Lupus 1.4 2.2 5.6 2.4 -0.8 -0.8 -1.6 -2.2 -0.5 -0.8
Neuroticism (2016) 4.0 5.8 8.8 -1.8 2.7 2.3 3.0 0.8 2.9 2.6
Primary Biliary Cirrhosis 1.5 2.1 5.2 2.3 -1.4 -0.6 -2.0 0.9 -1.4 -0.6
Rheumatoid Arthritis 0.3 0.5 1.1 0.4 0.5 0.8 0.1 0.8 0.7 1.1
Schizophrenia (2014) 1.1 2.4 7.2 -1.7 -1.0 -1.8 -0.8 -2.7 -0.8 -1.1
Triglycerides 6.2 10.2 30.0 5.5 -3.0 -0.7 -2.8 3.1 -3.1 -2.2
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 -0.3 -0.1 -0.4 0.2 -0.7 -0.0 -0.0
Ulcerative Colitis 0.3 0.5 1.4 0.4 0.8 1.2 -0.3 0.7 0.6 0.6
Blood Eosinophil Count 1.7 12.8 38.7 -5.3 -0.4 -3.0 0.3 -6.2 -1.0 -3.6
Blood Platelet Count 0.1 0.8 2.9 0.8 0.3 0.2 -1.1 -0.7 -0.3 -1.7
Blood Red Count 8.4 81.6 130.0 -5.9 10.7 9.4 9.5 2.1 11.4 10.4
Blood White Count 0.8 5.9 22.5 -4.7 1.4 -0.2 3.0 -2.1 1.8 0.6
Heel T-Score 2.0 15.9 50.0 -7.1 3.1 0.4 5.1 -3.1 3.4 2.1
BMI 6.1 35.6 116.6 10.8 -4.6 0.0 -6.9 6.2 -4.6 -2.2
Height 0.2 3.5 11.6 1.4 -3.4 -2.4 -1.0 0.2 -2.0 -0.5
Waist Hip Ratio (WHR) 0.3 1.5 6.3 -2.5 0.1 -0.4 1.1 -1.0 0.7 1.1
Systolic Blood Pressure 0.6 2.9 14.4 1.3 0.1 1.1 0.4 3.8 0.3 1.7
Smoking Status 1.9 4.5 12.1 3.5 -1.7 -0.0 -2.5 2.3 -1.8 -1.4
Allergy or Eczema 1.4 3.7 7.1 -2.7 -1.4 -2.6 0.1 -2.5 -1.2 -1.6
Cardiovascular Disease 5.8 19.1 41.9 6.5 -4.5 -1.7 -5.5 3.1 -4.5 -2.8
Hypothyroidism (self reported) 0.6 1.5 2.6 -0.9 1.3 1.1 1.1 -0.1 1.5 1.6
Respiratory disease 2.2 5.0 8.8 1.5 -2.8 -2.1 -3.0 -0.2 -2.8 -2.0
Type 2 Diabetes (T2D) (2018) 1.6 3.0 9.6 3.1 -1.3 0.4 -1.4 2.6 -1.0 -0.1
Lung FEV1/FVC ratio 0.9 4.8 10.2 -3.2 2.5 1.4 2.3 -1.5 2.4 1.2
Lung FVC 7.3 37.3 56.4 -5.5 7.1 5.5 6.7 0.0 7.5 7.0
Neuroticism 8.2 19.8 31.4 -2.8 5.4 4.6 4.6 0.3 5.6 5.2
Chronotype (morning person) 0.8 1.9 3.1 0.6 1.3 1.6 1.1 1.6 1.4 1.8
Hair Pigment 0.1 1.7 5.2 -2.3 1.2 0.4 1.7 -0.6 1.0 0.8
Tanning 0.1 1.2 5.5 -0.8 -0.3 -0.9 -0.3 -2.4 -0.4 -1.1
Hand grip strength (left) 2.5 6.5 13.6 3.7 -2.8 -1.4 -2.8 1.1 -2.9 -2.1
Number of treatments/medications taken 5.6 10.1 15.1 2.9 -3.9 -2.9 -3.8 -0.2 -3.8 -3.2
Average weekly spirits intake 0.2 0.2 0.5 0.6 -0.5 -0.2 -0.1 0.7 -0.5 -0.2
Sensitivity / hurt feelings 2.3 3.9 6.7 -1.4 2.3 1.8 2.1 -0.3 2.6 2.4
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.3 0.5 1.3 1.5 -0.1 -0.1 1.1 0.6
Hearing difficulty/problems: Yes 3.0 4.5 7.0 1.8 -2.0 -1.8 -2.6 -0.4 -2.6 -2.6
Relative age of first facial hair 2.0 4.2 8.7 2.6 -2.2 -1.4 -3.0 -0.5 -2.0 -1.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.6 0.9 -0.4 -0.1 -1.3 0.2 -0.5 -0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.4 -0.0 0.2 0.4 0.2 1.2 0.3 0.6
Ever had hysterectomy (womb removed) 2.3 2.6 8.6 2.9 -1.0 0.0 -2.2 0.6 -1.1 -1.2
Systolic blood pressure, automated reading 1.5 4.3 15.5 3.1 0.2 1.7 -0.5 3.9 0.2 1.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.7 0.4 -0.6 -0.2 -0.6 0.7 -0.7 -0.8
Angina 1.0 1.3 2.5 1.2 1.0 1.6 -0.1 1.3 0.9 1.2
Medication for hormone replacement therapy 0.2 0.3 0.6 -0.4 -0.4 -0.6 -0.8 -0.4 -0.5 -0.5
Vitamin and mineral supplements 0.5 0.7 4.2 -0.5 0.4 -0.0 0.2 -2.0 0.3 -0.5
Supplements: Zinc 0.5 0.5 1.2 -1.1 0.5 0.3 0.9 0.2 0.7 1.0
Medication: Co-codamol 2.4 2.8 8.8 3.0 -1.1 0.2 -2.0 2.0 -1.1 -0.6
Medication: Metformin 1.0 1.5 2.8 1.5 -1.7 -0.9 -0.9 0.9 -1.3 -1.1
Diabetes (father) 0.7 0.8 2.5 -1.6 -0.1 -0.6 1.6 0.3 0.2 0.6
Diabetes (mother) 1.7 2.2 10.0 3.2 -0.7 0.7 -1.7 1.3 -0.3 -0.0
Severe depression (siblings) 0.0 0.0 0.1 -0.3 -0.0 -0.1 -0.0 -0.3 -0.1 0.0
Pack years adult smoking proportion 1.5 2.2 4.7 2.2 -1.5 -0.8 -1.7 0.5 -1.6 -1.6
Impedance of leg (right) 2.6 12.4 39.6 -6.3 -0.3 -3.1 2.5 -5.3 -0.1 -1.7
Leg fat-free mass (left) 3.0 15.8 57.0 7.5 -2.7 0.8 -4.4 4.7 -2.2 -0.1
Trunk fat percentage 6.9 27.8 64.5 8.0 -5.7 -2.3 -6.5 3.0 -5.4 -3.7
Hand grip strength (right) 1.5 4.1 8.2 2.9 -2.4 -1.2 -2.1 1.2 -2.3 -1.5
Townsend deprivation index at recruitment 4.1 5.7 11.0 3.3 -2.4 -0.8 -3.1 1.9 -2.4 -1.9
Current tobacco smoking 1.1 1.8 5.1 2.3 -0.6 0.6 -1.3 2.1 -0.6 0.1
Average weekly fortified wine intake 0.3 0.4 1.1 -0.6 -0.6 -1.1 0.1 -0.4 -0.7 -0.5
Maternal smoking around birth 0.6 0.9 4.0 0.3 0.5 0.9 0.7 2.0 0.4 0.8
Fed-up feelings 3.4 6.2 12.3 -0.3 2.9 3.0 1.9 0.9 3.1 3.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 5.3 1.8 1.4 2.3 -0.3 1.1 1.2 0.8
Relative age voice broke 5.0 7.6 10.6 1.6 -3.2 -2.9 -2.9 -1.6 -3.2 -3.3
Taking other prescription medications 1.1 1.7 3.2 1.0 -1.8 -1.2 -1.6 0.1 -1.5 -1.3
Age when periods started (menarche) 1.1 2.6 11.1 -1.8 -0.7 -1.6 -0.6 -3.3 -0.3 -0.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.0 1.0 -0.3 0.1 -0.8 0.4 -0.4 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.9 -1.7 0.9 0.5 1.4 -0.4 1.2 0.8
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 2.3 0.6 -1.2 -1.0 -1.5 -1.2 -1.0 -1.0
Qualifications: CSEs or equivalent 0.3 0.4 1.2 1.1 -0.4 0.1 -1.0 0.3 -0.1 0.8
Serious illness, injury or assault to yourself 0.4 0.5 1.0 1.0 0.1 0.8 -0.8 1.0 0.1 0.5
High blood pressure 4.2 11.8 33.0 5.7 -3.2 -0.6 -4.4 3.0 -3.0 -1.2
Hayfever, allergic rhinitis or eczema 1.3 2.9 7.8 -2.8 -1.0 -2.0 0.3 -2.4 -0.7 -1.0
Multivitamins +/- minerals 0.2 0.2 1.2 -0.1 -0.2 -0.0 0.2 1.1 -0.0 0.3
Stomach or abdominal pain in last month 0.0 0.1 0.1 -0.4 0.1 0.1 -0.3 0.0 -0.1 -0.3
Supplements: Glucosamine 0.4 0.6 1.7 -1.3 0.0 -0.6 1.0 -0.7 -0.0 -0.7
Diverticular disease/diverticulitis (self-reported) 2.4 2.9 5.8 0.3 1.8 2.2 1.1 0.6 2.1 2.4
Medication: Atenolol 1.1 1.4 2.9 1.4 1.0 1.7 0.3 1.3 1.0 0.9
Medication: Levothyroxine sodium 0.1 0.1 0.4 -0.2 0.2 0.2 0.2 -0.1 0.4 0.6
Sitting height 0.6 4.0 6.5 0.0 2.2 2.5 1.8 1.6 2.4 2.3
Chronic bronchitis/emphysema (father) 5.6 6.6 13.4 2.0 -2.7 -2.0 -3.7 -0.6 -3.1 -2.7
High blood pressure (mother) 1.0 1.4 5.1 2.3 -0.2 0.8 -1.0 1.7 -0.0 0.6
Body mass index (BMI) 7.5 32.1 107.4 10.4 -4.2 0.2 -6.4 6.0 -4.2 -2.0
Impedance of leg (left) 2.2 10.6 35.0 -5.9 -0.1 -2.7 2.6 -4.8 0.1 -1.3
Leg predicted mass (left) 3.0 15.7 56.9 7.5 -2.7 0.7 -4.3 4.7 -2.2 -0.1
Trunk fat mass 6.8 29.2 78.7 8.9 -5.4 -1.7 -6.6 3.9 -5.1 -3.0
Waist circumference 9.4 34.6 96.8 9.8 -5.6 -1.3 -7.1 5.0 -5.3 -2.9
Number of incorrect matches in round 6.1 10.2 29.8 -5.5 2.7 0.2 3.4 -3.4 2.8 1.9
Past tobacco smoking 1.5 2.8 6.7 -2.6 1.5 0.3 1.8 -1.5 1.6 1.6
Alcohol usually taken with meals 0.4 0.7 2.5 -1.0 -0.2 -1.0 -0.3 -1.6 -0.3 -0.6
Nervous feelings 5.8 10.9 19.2 -3.9 4.4 2.6 3.2 -1.8 3.7 2.8
Frequency of tenseness / restlessness in last 2 weeks 4.0 6.2 11.6 -1.1 3.4 3.2 1.5 0.5 3.2 2.8
Hearing difficulty/problems with background noise 0.9 1.4 2.5 0.1 -1.4 -1.5 -1.1 -0.3 -1.6 -1.4
Hair/balding pattern: Pattern 2 0.2 0.2 1.1 -1.0 0.2 -0.2 0.4 -0.1 -0.2 0.0
Had menopause 2.9 3.6 5.6 1.8 -2.1 -1.6 -2.4 -0.6 -2.2 -2.0
Had other major operations 1.4 1.7 4.9 2.2 -1.0 0.1 -1.7 1.5 -0.9 0.3
Forced vital capacity (FVC) 6.1 23.4 39.4 -4.2 5.1 3.9 5.5 -0.3 5.9 6.3
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 7.0 -2.7 1.2 0.4 2.1 -0.9 1.8 1.5
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.1 0.2 1.4 1.8 0.4 0.5 1.6 1.6
Qualifications: None of the above 0.9 1.9 6.3 1.9 0.4 1.4 -0.1 2.5 0.3 0.8
Financial difficulties in last 2 years 4.5 6.0 18.9 4.4 -1.8 0.4 -3.6 1.9 -1.7 -0.8
Mouth/teeth dental problems 0.8 1.2 4.1 -2.0 0.3 -0.6 1.3 -1.5 0.4 0.2
Heart attack 0.9 1.1 3.0 0.8 -1.1 -0.8 -1.1 -0.4 -1.0 -1.7
Allergy 2.6 5.9 10.6 1.5 2.5 3.2 1.5 2.8 2.4 2.5
Pain all over the body in last month 3.5 3.8 6.9 1.9 -2.2 -1.5 -2.6 0.1 -2.2 -2.0
Diabetes (self-reported) 1.9 2.9 5.0 2.2 -2.0 -0.7 -1.4 2.2 -1.7 -1.0
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 8.8 -3.0 -0.3 -1.5 0.9 -2.4 -0.1 -0.4
Medication: Ramipril 2.3 3.0 10.5 3.2 -1.3 -0.2 -2.0 0.7 -1.4 -1.4
Medication: Simvastatin 4.1 6.0 12.2 3.5 -2.4 -1.1 -2.9 0.8 -2.6 -2.6
Fluid intelligence score 3.0 6.2 13.5 2.4 -2.0 -1.4 -3.7 -0.4 -2.8 -3.1
Illnesses of siblings 6.7 9.4 25.1 -5.0 2.5 0.5 3.6 -2.9 2.9 1.9
Neuroticism score 8.7 18.1 28.2 -2.2 5.2 4.6 4.1 1.0 5.3 5.3
Weight 6.3 31.2 99.4 10.0 -4.9 -0.5 -6.5 5.3 -4.4 -1.9
Impedance of arm (right) 2.9 13.3 38.6 -6.1 -0.6 -3.4 1.8 -6.2 -0.2 -1.4
Arm fat percentage (right) 7.3 28.9 83.5 9.1 -5.0 -1.2 -6.6 3.9 -4.9 -3.0
Trunk fat-free mass 1.8 10.5 37.6 6.1 -1.3 1.7 -2.6 4.8 -0.8 1.1
Hip circumference 10.1 43.4 123.2 11.1 -6.2 -1.6 -7.9 5.2 -6.0 -3.7
Time employed in main current job 0.2 0.2 0.6 -0.2 -0.8 -0.8 -0.3 -0.1 -0.4 0.3
Alcohol intake versus 10 years previously 1.9 2.8 4.7 0.4 -2.1 -1.9 -1.9 -0.4 -2.2 -1.8
Father’s age at death 1.6 2.1 5.3 -2.3 1.1 0.3 2.1 -0.7 1.4 1.1
Worrier / anxious feelings 8.3 15.7 28.1 -1.7 5.3 4.8 3.3 0.3 5.1 4.3
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 2.6 1.6 0.5 1.4 -1.6 1.6 0.2 1.1
Falls in the last year 3.2 4.3 9.6 3.0 -2.0 -0.7 -3.1 1.1 -2.0 -1.4
Hair/balding pattern: Pattern 3 3.8 5.7 8.4 1.7 -2.7 -2.4 -2.4 -1.7 -2.6 -2.9
Number of live births 0.5 0.8 1.4 1.0 0.8 1.2 -0.1 0.5 0.9 1.1
Forced expiratory volume in 1-second (FEV1) 7.2 24.3 36.7 -4.4 5.5 4.2 5.6 -0.2 6.1 6.0
Pulse rate 0.5 0.8 2.1 -0.3 -1.3 -1.5 -0.5 -0.4 -1.0 -0.3
Happiness 1.4 1.7 2.9 -1.7 1.3 0.6 1.0 -1.5 1.5 1.1
Noisy workplace 0.9 1.1 1.9 0.0 1.0 1.2 0.8 1.1 1.1 1.4
Qualifications: A levels/AS levels or equivalent 3.1 6.9 16.9 -3.1 -1.5 -3.2 -0.4 -4.1 -1.6 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.5 0.2 0.1 0.2 -0.2 0.3 0.5
Mouth/teeth dental problems: Dentures 0.5 0.8 1.9 1.1 0.6 1.1 -0.3 1.4 0.5 0.7
Asthma 4.6 9.0 12.7 0.9 -3.5 -3.4 -3.5 -2.1 -3.6 -3.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.2 1.1 -0.9 -0.7 -1.5 -0.6 -1.1 -0.9
Medication: Cholesterol lowering 6.0 9.3 16.6 4.1 -3.1 -1.6 -3.6 0.9 -3.4 -3.3
Depression (self-reported) 0.6 0.7 1.8 0.4 0.9 1.1 0.7 1.4 0.6 0.6
Medication: Lansoprazole 0.5 0.6 2.2 1.5 -0.3 0.1 -0.7 0.6 -0.6 -0.9
Prospective memory result 1.9 2.4 5.4 -1.3 1.3 1.3 1.5 1.0 1.7 2.3
Lung cancer (father) 0.6 0.7 2.2 -0.1 0.3 0.4 -1.1 -1.5 0.5 1.0
Illnesses of mother 1.1 1.4 4.3 -2.1 1.0 0.4 1.1 -0.8 1.1 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 7.3 23.3 35.3 -5.1 5.2 3.6 5.5 -1.5 5.9 5.4
Pulse wave Arterial Stiffness index 2.2 2.5 9.2 3.0 -1.2 0.2 -1.7 1.8 -1.0 -0.2
Impedance of arm (left) 2.9 13.3 38.8 -6.0 -0.8 -3.5 1.6 -6.2 -0.4 -1.6
Arm fat mass (right) 7.5 30.7 97.0 9.8 -4.8 -0.6 -6.5 5.2 -4.5 -2.1
Trunk predicted mass 1.8 10.3 36.8 6.1 -1.3 1.7 -2.6 4.7 -0.8 1.1
Standing height 0.1 1.0 2.7 -0.4 -1.6 -1.5 -0.3 -1.2 -0.6 0.4
Length of working week for main job 0.1 0.1 0.4 -0.2 0.4 0.2 0.6 0.2 0.4 0.3
Exposure to tobacco smoke at home 0.8 0.9 2.3 1.5 -1.0 -0.5 -1.2 0.0 -0.9 -0.6
Breastfed as a baby 5.1 6.3 10.6 0.7 -3.3 -3.0 -2.4 -1.5 -2.9 -2.8
Tense / ‘highly strung’ 9.6 15.9 24.8 -3.5 5.0 3.7 4.3 -0.4 4.8 4.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 4.7 -0.8 2.2 2.0 1.5 0.3 2.1 2.1
Hair/balding pattern: Pattern 4 0.6 1.6 2.7 0.1 1.3 1.6 1.0 1.5 1.4 1.3
Birth weight of first child 3.6 6.6 11.3 1.6 -3.4 -2.7 -3.0 -0.2 -3.2 -2.5
Peak expiratory flow (PEF) 2.1 4.8 7.4 -0.7 2.3 2.4 2.4 1.1 2.7 2.7
Pulse wave reflection index 1.4 1.7 5.9 2.4 0.1 1.3 -0.8 1.9 0.2 0.3
Ever highly irritable/argumentative for 2 days 2.2 2.6 4.3 -1.2 1.8 1.6 1.7 0.3 2.1 2.0
Loud music exposure frequency 0.9 1.0 2.8 1.7 0.1 0.6 -1.6 0.2 -0.5 -1.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 3.0 -1.2 -1.1 -1.7 -0.6 -1.7 -1.1 -1.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.1 0.9 -0.8 -0.5 -1.0 0.1 -0.7 -0.3
Blood clot in the leg (DVT) 1.5 2.0 4.3 0.9 -0.9 -1.0 -1.6 -1.2 -1.6 -2.1
Medication: Paracetamol 2.6 4.2 9.9 3.0 -1.8 -0.6 -3.1 0.6 -2.0 -1.5
Headache pain in last month 1.5 2.5 6.5 2.2 -1.2 -0.4 -2.6 0.7 -1.7 -1.2
Medication for cholesterol, blood pressure or diabetes 2.7 4.4 12.4 -3.5 1.8 0.4 2.2 -1.9 1.9 1.7
Glaucoma (self-reported) 1.5 1.8 3.0 -1.4 1.4 0.9 1.7 -0.1 1.5 1.6
Gout (self-reported) 0.6 0.8 3.0 -1.7 0.0 -0.8 0.4 -1.3 -0.0 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 -0.7 0.5 0.4 0.6 -0.1 0.7 0.8
Medication: Amlodipine 0.5 0.7 1.0 0.1 0.7 1.0 0.9 0.8 0.9 0.9
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.5 0.4 -1.5 -1.6 -0.9 -0.8 -1.4 -0.8
Birth weight 0.9 2.0 8.2 2.9 -0.6 0.6 -1.6 1.4 -0.6 -0.4
Chronic bronchitis/emphysema (mother) 5.6 6.5 10.3 1.6 -2.9 -2.4 -2.9 -0.8 -3.1 -3.2
High blood pressure (siblings) 7.0 10.1 22.9 4.8 -3.1 -1.0 -3.9 2.9 -3.2 -1.9
Forced vital capacity (FVC), Best measure 5.5 20.2 31.5 -4.4 4.7 3.4 4.9 -1.3 5.6 5.5
Body fat percentage 7.7 30.3 74.3 8.6 -5.7 -2.1 -6.7 3.4 -5.5 -3.8
Leg fat percentage (right) 7.0 25.3 62.9 7.9 -5.0 -1.8 -6.0 3.4 -5.1 -3.6
Arm fat-free mass (right) 3.1 15.8 55.1 7.4 -2.5 1.0 -3.8 5.5 -2.0 0.1
Exposure to tobacco smoke outside home 1.8 2.4 6.8 2.6 -1.1 0.2 -1.8 2.0 -1.2 -0.7
Comparative body size at age 10 5.5 15.2 23.6 3.8 -4.8 -3.4 -4.5 0.8 -4.9 -3.6
Number of full brothers 2.1 2.7 7.9 2.8 -0.7 0.6 -1.6 2.6 -0.7 -0.1
Worry too long after embarrassment 1.6 2.8 4.3 -1.4 1.7 1.4 2.1 -0.0 2.0 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.0 -1.1 1.4 1.1 1.1 0.1 1.3 1.4
Wheeze or whistling in the chest in last year 5.6 10.0 20.7 4.0 -3.2 -1.9 -4.6 0.1 -3.6 -2.6
Number of children fathered 0.2 0.2 0.5 0.7 0.6 0.6 -0.1 0.2 0.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.9 -0.7 0.4 0.0 1.4 0.2 0.4 0.4
Age at first live birth 1.5 2.7 8.3 -2.9 0.8 -0.5 1.8 -2.3 1.1 0.5
Pulse wave peak to peak time 2.1 2.5 9.3 -3.0 1.1 -0.4 1.6 -1.9 0.9 0.2
Health satisfaction 2.1 2.7 9.0 2.6 0.5 1.6 -0.3 3.0 0.3 0.5
Shortness of breath walking on level ground 1.1 1.3 4.0 2.0 0.5 1.3 -1.5 1.1 -0.1 0.1
Qualifications: College or University degree 1.8 5.7 17.0 -3.9 -0.1 -2.0 1.1 -4.1 -0.0 -1.7
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.6 -0.1 0.2 -0.5 -0.2 -0.1 -0.4
Mouth/teeth dental problems: Loose teeth 1.5 1.7 5.5 2.1 -0.9 0.3 -0.9 2.4 -0.4 0.5
Emphysema/chronic bronchitis 2.1 2.3 3.9 2.0 -1.9 -1.1 -2.0 0.2 -1.6 -1.1
Medication for pain relief, constipation, heartburn 3.6 6.2 11.3 -2.4 2.6 1.8 3.4 0.8 2.8 2.9
Neck or shoulder pain in last month 1.7 2.5 6.9 2.6 -1.4 -0.2 -2.4 1.0 -1.2 -0.4
Medication: Blood pressure 1.5 2.6 8.8 3.0 -0.6 0.8 -0.6 2.8 -0.3 0.2
Angina (self-reported) 0.9 1.2 2.4 1.2 1.0 1.6 -0.1 1.3 0.9 1.1
Migraine (self-reported) 0.3 0.4 2.3 0.2 0.2 0.5 -0.1 1.5 -0.0 0.1
Medication: Ibuprofen 0.9 1.1 1.8 0.9 -1.0 -0.8 -1.3 -1.1 -1.1 -1.0
Medication: Allopurinol 1.1 1.5 6.4 -2.5 0.5 -0.5 0.8 -1.6 0.4 -0.2
Medication: Omeprazole 0.2 0.2 0.5 -0.3 -0.7 -0.6 -0.4 -0.0 -0.4 0.1
Medication: Seretide 50 evohaler 1.0 1.1 2.1 -0.3 -1.0 -1.2 -0.9 -0.9 -1.2 -1.4
Mean time to correctly identify matches 0.6 1.1 2.6 0.3 -0.8 -0.9 -1.6 -1.2 -1.1 -1.2
Heart disease (mother) 0.6 0.7 1.7 0.3 0.8 1.0 0.9 1.3 0.8 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 3.6 1.9 -1.5 -0.9 -1.5 0.6 -1.7 -1.9
Whole body fat mass 7.2 30.1 85.2 9.2 -5.2 -1.3 -6.6 4.5 -5.0 -2.8
Leg fat mass (right) 7.6 29.5 84.5 9.2 -5.1 -1.2 -6.4 4.6 -4.9 -2.9
Arm predicted mass (right) 3.2 16.2 55.5 7.5 -2.7 0.8 -3.9 5.5 -2.2 -0.0
Pulse rate, automated reading 2.6 8.3 16.3 1.7 -4.0 -3.4 -3.2 -0.0 -3.7 -2.0
Alcohol intake frequency. 3.9 9.0 32.0 5.7 -1.7 0.9 -3.7 3.5 -1.4 0.3
Comparative height size at age 10 0.1 0.4 1.4 0.2 -1.2 -0.6 -0.1 0.9 -0.5 0.2
Number of full sisters 4.6 5.6 9.5 1.8 -3.0 -2.2 -3.1 0.5 -3.0 -1.8
Suffer from ‘nerves’ 3.2 5.0 10.7 -2.0 3.3 2.3 1.4 -1.5 2.8 1.6
Overall health rating 5.9 12.6 37.9 6.2 -2.6 0.2 -5.0 3.1 -2.7 -1.4
Chest pain or discomfort 1.8 2.6 6.4 2.5 -1.3 -0.3 -2.2 1.0 -1.7 -1.2
Had major operations 1.0 1.2 2.7 1.6 -1.1 -0.2 -1.2 1.3 -0.9 -0.9
Age at last live birth 0.7 1.0 2.5 -1.6 0.8 0.1 0.5 -1.6 0.9 0.5
Family relationship satisfaction 2.2 2.8 4.2 0.2 -1.9 -2.0 -1.5 -1.7 -1.8 -1.8
Leg pain on walking 4.3 5.4 9.7 0.8 2.1 2.7 1.7 3.1 2.2 2.9
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 4.1 1.3 0.9 1.8 0.4 2.0 1.3 1.7
Commuting to job workplace: Car/motor vehicle 1.9 2.2 5.3 0.4 1.3 1.7 1.6 2.3 1.2 1.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.1 -1.3 -0.8 -1.8 0.1 -1.5 -1.1 -1.4
Medication: Aspirin 2.2 2.9 5.9 2.2 -1.7 -0.9 -1.4 0.6 -1.9 -2.4
Supplements: Vitamin C 0.2 0.2 1.3 -1.1 0.1 -0.2 0.3 0.3 0.2 0.2
Knee pain experienced in last month 6.6 10.2 23.1 4.8 -3.0 -1.2 -4.2 0.9 -3.4 -2.9
Hypertension (Self-reported) 4.5 12.5 32.0 5.7 -3.6 -1.1 -4.6 2.7 -3.3 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.5 -1.6 0.2 -0.2 1.4 0.1 0.5 0.9
Illnesses of father: Heart disease 0.2 0.3 0.8 0.2 -0.4 -0.2 -0.6 0.3 -0.7 -0.9
Illnesses of siblings: Diabetes 1.2 1.5 4.5 2.1 -0.8 0.2 -1.6 1.2 -0.8 -0.7
Smoking status: Previous 1.5 2.2 4.4 2.1 -1.4 -0.5 -1.7 0.8 -1.6 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.0 -0.4 0.7 0.6 0.5 -0.7 1.0 0.8
Whole body fat-free mass 2.4 13.8 50.0 7.1 -2.0 1.4 -3.5 5.1 -1.4 0.7
Leg fat-free mass (right) 2.8 15.0 55.4 7.4 -2.3 1.1 -4.1 4.8 -1.8 0.4
Arm fat percentage (left) 7.3 29.3 83.4 9.1 -5.2 -1.3 -6.7 4.0 -4.9 -3.0
Average weekly red wine intake 0.1 0.1 0.3 -0.6 0.5 0.1 0.3 -0.4 0.3 -0.3
Handedness (chirality/laterality): Left-handed 1.9 2.3 4.2 0.9 -1.8 -1.5 -1.7 0.5 -2.0 -1.5
Mood swings 5.8 10.5 17.2 -0.7 3.8 3.8 2.9 1.7 3.9 4.1
Loneliness, isolation 5.5 7.6 14.9 1.1 3.0 3.9 1.3 2.3 3.0 3.4
Long-standing illness, disability or infirmity 2.3 3.6 8.0 1.6 -1.9 -1.5 -2.8 -0.1 -2.3 -1.9
Ever had bowel cancer screening 0.1 0.2 0.4 0.6 0.4 0.5 -0.1 0.6 0.1 0.0
Diabetes diagnosed by doctor 2.1 3.5 6.5 2.6 -2.1 -0.7 -1.9 2.0 -1.9 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.3 -0.8 1.0 0.9 0.9 0.4 1.1 0.9
Friendships satisfaction 0.4 0.5 2.0 -1.4 0.2 -0.4 0.5 -1.1 0.2 0.1
Qualifications: nursing, teaching 1.2 1.9 4.8 -2.2 -0.8 -1.6 0.1 -1.8 -0.6 -1.3
Commuting to job workplace: Walk 0.8 0.9 2.9 -1.7 -0.1 -0.7 0.1 -1.5 0.3 0.8
Eye problems/disorders: Cataract 0.3 0.4 0.9 0.4 -0.8 -0.6 -1.0 -0.3 -0.7 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 4.8 2.2 -1.0 -0.2 -2.0 0.5 -1.3 -1.7
Medication for cholesterol 6.6 10.0 19.3 -3.6 3.5 2.1 4.4 -1.1 3.6 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 5.1 0.1 0.8 1.4 0.1 2.3 0.8 1.5
Back pain experienced in last month 1.0 1.4 4.8 0.8 -1.3 -0.8 -2.2 -0.1 -1.3 -0.6
Mineral and other dietary supplements 0.3 0.4 1.8 1.4 -0.1 0.4 -0.8 -0.4 0.0 -0.3
Breast cancer (self-reported) 0.2 0.3 0.8 -0.7 -0.2 -0.7 0.1 -0.9 -0.3 0.1
Asthma (self-reported) 4.3 8.5 11.4 0.9 -3.3 -3.2 -3.3 -2.3 -3.4 -3.1
Osteoporosis (self-reported) 1.8 2.2 3.5 1.9 -1.6 -1.1 -1.6 -0.7 -1.3 -1.8
Osteoarthritis (self-reported) 0.1 0.2 0.4 0.0 -0.6 -0.6 -0.4 -0.0 -0.6 0.0
Medication: Aspirin 1.2 1.5 4.3 2.1 -1.0 -0.3 -0.7 0.8 -1.1 -1.7
Medication: Gliclazide 0.6 0.7 3.2 0.6 -0.8 -0.2 0.3 1.8 -0.4 0.4
Illnesses of father: None of the above (group 1) 1.2 1.5 2.9 -0.9 1.1 0.8 1.2 -1.0 1.6 1.7
Smoking status: Current 0.7 1.2 3.6 1.8 -0.3 0.7 -0.9 1.9 -0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 12.0 25.4 37.7 -6.1 5.7 3.5 5.7 -1.8 5.9 5.0
Whole body water mass 2.4 13.6 49.1 7.0 -2.0 1.4 -3.4 5.1 -1.4 0.6
Leg predicted mass (right) 2.8 14.8 54.6 7.4 -2.4 1.0 -4.1 4.7 -1.9 0.3
Arm fat mass (left) 7.8 32.1 98.2 9.9 -5.1 -0.8 -6.7 5.1 -4.8 -2.4
Number of self-reported non-cancer illnesses 4.0 7.0 11.1 2.9 -3.0 -2.0 -3.3 0.3 -3.1 -2.6
Average weekly champagne plus white wine intake 0.3 0.4 1.0 1.0 0.0 0.2 -1.0 0.0 -0.4 -0.6
Miserableness 2.4 4.1 7.7 -0.0 2.8 2.7 1.3 0.1 2.6 2.3
Guilty feelings 3.1 4.6 9.1 -0.3 2.4 2.6 1.7 1.3 2.5 3.0
Wears glasses or contact lenses 0.5 0.6 2.0 0.7 -0.5 -0.2 -0.8 1.4 -0.5 0.5
Ever taken oral contraceptive pill 0.3 0.4 1.6 0.4 0.3 0.6 0.3 1.3 0.3 0.6
Hearing aid user 1.2 1.3 5.0 2.2 0.1 0.8 -0.8 1.7 -0.4 -0.1
Mother’s age at death 0.1 0.1 0.3 -0.6 -0.0 -0.4 -0.1 -0.4 -0.3 -0.3
Financial situation satisfaction 0.7 0.8 2.5 1.6 0.1 0.9 -0.3 1.6 -0.0 0.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.6 1.6 0.1 0.6 -0.1 1.4 0.0 0.2
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.9 -0.7 -0.5 -0.7 -0.4 -0.6 -0.5
Eye problems/disorders: Glaucoma 1.8 2.2 5.7 -1.8 1.3 0.6 2.4 0.0 1.4 1.4
Medication: Blood pressure 3.6 6.9 15.1 3.9 -2.8 -1.2 -3.5 1.8 -2.6 -1.1
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.9 1.3 -0.6 0.1 -1.4 0.6 -0.5 0.4
Supplements: Fish oil (including cod liver oil) 1.8 2.4 3.7 -1.5 1.8 1.2 1.9 1.0 1.4 1.8
High cholesterol (Self-reported) 5.8 10.3 14.2 3.8 -3.5 -2.1 -3.5 1.2 -3.8 -3.7
Medication: Bendroflumethiazide 3.5 5.3 15.6 4.0 -2.3 -0.7 -2.8 2.0 -1.9 -0.4
Medication: Paracetamol 2.1 3.3 8.9 2.9 -1.3 -0.2 -3.0 0.4 -1.6 -1.2
Medication: Lisinopril 1.2 1.6 5.9 1.3 -1.4 -0.7 -0.1 2.4 -1.0 0.0
Medication: Atorvastatin 5.2 6.4 9.9 3.1 -2.8 -1.7 -3.0 0.3 -2.8 -2.8
Illnesses of father: High blood pressure 1.7 2.1 5.2 2.3 -0.7 0.4 -1.7 2.2 -1.0 -0.4
Alcohol drinker status: Never 0.1 0.2 0.3 0.6 0.4 0.5 -0.2 -0.2 0.3 0.5
Ever smoked 0.9 1.6 4.1 2.0 -0.8 0.3 -1.3 1.8 -0.9 -0.7
Basal metabolic rate 3.2 17.9 63.8 8.0 -2.8 1.0 -4.3 5.4 -2.2 0.1
Leg fat percentage (left) 7.2 26.1 68.9 8.3 -4.9 -1.6 -6.2 3.6 -5.0 -3.3
Arm fat-free mass (left) 3.5 17.6 61.3 7.8 -2.5 1.1 -4.1 5.8 -2.1 0.2
Number of operations (self-reported) 1.3 2.0 5.2 2.3 -1.3 0.1 -1.4 2.0 -1.0 -0.3
Average weekly beer plus cider intake 0.1 0.2 0.5 -0.7 0.6 0.3 0.4 -0.6 0.3 -0.2
Irritability 10.3 17.4 26.5 -2.8 4.6 4.1 4.7 1.5 5.1 5.1
Risk taking 0.7 1.0 2.2 0.9 -0.9 -0.6 -1.0 0.3 -1.3 -1.5
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.1 0.6 0.6 0.1 0.1 0.5 0.7
Fractured/broken bones in last 5 years 4.9 6.3 14.6 3.8 -2.2 -0.8 -3.6 0.6 -2.4 -2.2
Age started oral contraceptive pill 0.4 0.5 0.9 0.1 -0.9 -0.9 -0.6 -0.8 -0.8 -0.7
Diastolic blood pressure, automated reading 4.6 14.1 39.2 6.3 -3.8 -1.3 -4.9 2.2 -3.5 -1.5
Ever depressed for a whole week 2.1 2.6 4.4 -1.0 1.8 1.6 1.7 0.2 2.1 2.0
Unable to work because of sickness or disability 3.8 4.9 16.0 4.0 -1.3 0.6 -3.0 2.3 -1.3 -0.5
Commuting to job workplace: Cycle 0.8 1.0 2.5 -0.7 -0.9 -1.3 -0.1 -1.0 -0.8 -1.6
Myopia 4.5 6.5 10.9 2.0 -2.7 -2.2 -3.3 -0.9 -3.1 -2.9
Vascular/heart problems diagnosed by doctor 4.6 12.6 37.7 -6.1 3.2 0.5 4.6 -2.9 3.0 1.4
Cholesterol lowering medication 8.8 13.0 23.1 4.6 -3.6 -2.0 -4.8 0.4 -3.9 -3.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.1 -0.4 -0.9 -1.0 -0.9 -0.8 -0.8 -0.5
Pain experienced in last month 7.3 12.2 24.8 -3.8 3.7 2.3 5.0 -0.2 4.0 3.3
Supplements: Calcium 0.2 0.2 0.4 -0.0 -0.6 -0.5 -0.6 0.3 -0.5 -0.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 -1.2 0.5 0.2 1.2 0.4 0.6 0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.1 2.9 0.9 -1.0 -0.7 -1.1 -0.5 -1.0 -1.7
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 4.2 0.9 -0.9 -1.0 -1.6 -1.1 -1.6 -2.0
Heart disease (siblings) 2.8 3.5 10.9 2.7 0.7 2.0 -0.5 3.3 0.4 1.0
Alcohol drinker status: Previous 1.7 1.9 7.2 2.7 -0.0 1.1 -1.1 1.9 -0.1 0.2
Pack years of smoking 1.9 2.8 4.6 2.1 -1.8 -1.1 -1.8 0.5 -1.9 -1.9
Impedance of whole body 2.9 14.9 44.5 -6.7 -0.6 -3.6 2.3 -6.2 -0.3 -1.7
Leg fat mass (left) 7.7 30.0 86.5 9.3 -5.1 -1.2 -6.5 4.6 -4.9 -2.8
Arm predicted mass (left) 3.6 18.4 64.2 8.0 -2.8 0.9 -4.2 5.7 -2.3 -0.2