TWAS hub - BCL7C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1090	0.0490	0.0040	0.013	NA	-0.003	NA	0.004	8.2e-02	NA	4.8e-01	NA	2.1e-01
2	GTEx	Muscle Skeletal	0.0945	0.0377	0.0019	0.089	NA	0.039	NA	0.059	4.5e-09	NA	8.8e-05	NA	1.8e-06
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0450	0.0307	0.0024	0.014	0.015	0.008	NA	0.009	9.8e-03	0.0069	3.9e-02	NA	2.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lupus	10.7	16.2	47.1	-6.9	0.4	-1.1
Irritability	7.9	13.4	35.9	2.1	0.2	6.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.8	16.4	30.4	4.2	1.2	5.5
Forced expiratory volume in 1-second (FEV1), Best measure	6.5	20.7	51.3	3.2	0.8	7.2
Cholesterol lowering medication	6.1	9.0	13.6	-3.7	1.1	-3.5
Forced vital capacity (FVC), Best measure	5.9	21.6	56.8	2.5	1.3	7.5
Neuroticism (Nagel 2018)	5.7	13.4	36.6	1.8	0.6	6.0
Hip circumference	5.5	23.6	44.9	-6.7	1.3	-4.9
Neuroticism	5.3	12.7	35.9	1.3	0.6	6.0
Neuroticism score	5.3	11.0	31.2	1.0	0.9	5.6
Tense / ‘highly strung’	5.3	8.8	25.4	0.6	0.7	5.0
Forced vital capacity (FVC)	5.2	20.2	54.8	2.3	0.7	7.4
Forced expiratory volume in 1-second (FEV1)	5.1	17.1	44.8	2.5	0.0	6.7
Lung FVC	4.8	24.5	62.1	2.6	2.2	7.9
Hayfever/allergic rhinitis (self-reported)	4.7	6.2	17.2	4.1	1.1	0.0
Hearing difficulty/problems: Yes	4.5	6.9	18.3	-1.6	0.2	-4.3
High cholesterol (Self-reported)	4.4	7.9	17.6	-1.5	1.9	-4.2
Body mass index (BMI)	4.3	18.4	40.1	-6.3	1.2	-3.7
Leg fat percentage (left)	4.3	15.4	27.2	-5.2	0.9	-4.3
Fractured/broken bones in last 5 years	4.3	5.5	10.2	-2.4	-0.6	-3.2
Worry (Nagel 2018)	4.2	8.9	19.8	2.4	1.0	4.5
Illnesses of siblings	4.2	5.9	10.6	2.6	0.3	3.3
Leg fat mass (left)	4.2	16.4	31.7	-5.6	1.0	-4.1
Blood Red Count	4.1	40.0	112.4	2.6	0.7	10.6
High blood pressure (siblings)	4.1	5.9	10.2	-2.7	-0.5	-3.2
Leg fat mass (right)	4.1	16.0	31.4	-5.6	1.1	-3.9
Leg fat percentage (right)	4.0	14.6	23.8	-4.9	0.9	-4.4
Arm fat mass (left)	3.9	16.2	34.7	-5.9	1.5	-3.4
Medication: Cholesterol lowering	3.8	5.9	16.5	-1.1	0.1	-4.1
Arm fat mass (right)	3.8	15.6	34.6	-5.9	1.2	-3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.8	4.4	11.0	3.3	-0.3	1.5
Waist circumference	3.7	13.5	26.0	-5.1	1.3	-3.6
Arm fat percentage (right)	3.7	14.4	28.7	-5.4	1.4	-3.6
Body fat percentage	3.7	14.6	25.3	-5.0	1.3	-4.1
Diastolic blood pressure, automated reading	3.7	11.6	18.7	-3.7	4.3	-1.6
Arm fat percentage (left)	3.6	14.4	29.4	-5.4	1.4	-3.4
Illnesses of father: None of the above (group 1)	3.6	4.4	13.1	-0.2	-0.5	3.6
Prospective memory result	3.5	4.4	8.1	2.2	0.0	2.9
Medication: Allopurinol	3.5	4.7	13.2	3.6	-0.9	0.1
Medication: Bendroflumethiazide	3.5	5.2	15.2	-3.9	-0.7	-0.2
Triglycerides	3.4	5.6	12.2	0.0	2.2	-3.5
Medication: Seretide 50 evohaler	3.4	3.9	7.0	2.6	-1.5	-1.6
Whole body fat mass	3.4	14.3	28.3	-5.3	1.1	-3.6
Medication for cholesterol	3.4	5.1	8.1	2.8	-1.4	2.3
Ever had hysterectomy (womb removed)	3.3	3.8	6.7	-2.6	0.8	-2.0
Chronic bronchitis/emphysema (father)	3.3	3.9	8.9	0.0	-1.7	-3.0
Worrier / anxious feelings	3.1	5.8	15.2	1.4	0.6	3.9
Vascular/heart problems diagnosed by doctor	3.1	8.6	20.2	4.5	-1.2	2.0
Depressed Affect (Nagel 2018)	3.0	6.4	18.7	-0.6	-0.1	4.3
BMI	2.9	16.7	35.2	-5.9	0.5	-3.8
Trunk fat percentage	2.9	11.6	19.4	-4.4	1.3	-3.7
Trunk fat mass	2.9	12.4	24.2	-4.9	1.3	-3.4
Weight	2.9	14.3	31.9	-5.7	1.6	-2.9
Leg pain on walking	2.9	3.6	6.3	-1.2	1.8	2.5
Number of incorrect matches in round	2.8	4.6	8.9	2.1	0.6	3.0
Medication: Simvastatin	2.8	4.1	8.8	-1.8	0.2	-3.0
Lung cancer (father)	2.8	3.2	8.0	-0.7	-1.1	2.8
Hearing aid user	2.8	3.2	5.5	-2.3	1.4	-1.4
Mood swings	2.7	4.9	14.7	-0.1	0.3	3.8
Tinnitus: Yes, now most or all of the time	2.7	3.1	8.5	-2.9	-0.1	-0.9
Fed-up feelings	2.6	4.8	14.1	-0.4	0.2	3.8
Wheeze or whistling in the chest in last year	2.6	4.6	12.2	-0.3	1.2	-3.5
Breast Cancer	2.5	6.1	9.3	-3.1	1.2	-2.7
Neuroticism (2016)	2.5	3.6	8.2	1.5	0.6	2.9
Ulcerative Colitis	2.5	3.6	10.6	0.0	-3.3	0.5
Asthma	2.5	4.9	10.3	1.9	-1.0	-3.2
Exposure to tobacco smoke outside home	2.5	3.3	8.5	-0.3	2.9	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	7.9	-0.9	-0.6	-2.8
Number of self-reported non-cancer illnesses	2.5	4.4	6.6	-1.1	2.6	-2.3
Cardiovascular Disease	2.4	7.8	12.2	-3.3	0.8	-3.5
Sensitivity / hurt feelings	2.4	4.2	10.9	0.6	1.1	3.3
Diverticular disease/diverticulitis (self-reported)	2.4	2.9	7.9	-0.6	0.6	2.8
Medication: Ramipril	2.4	3.0	7.5	-2.7	-0.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	7.0	-0.6	-2.0	-2.6
Asthma (self-reported)	2.4	4.8	9.5	2.0	-0.8	-3.1
Medication: Blood pressure	2.4	4.6	12.3	-3.5	1.0	-0.8
Medication: Atorvastatin	2.4	2.9	6.1	-1.7	0.1	-2.5
Nervous feelings	2.3	4.3	7.5	2.2	0.8	2.7
Overall health rating	2.3	4.9	11.0	-1.3	1.4	-3.3
Medication: Aspirin	2.3	3.1	4.5	-1.3	1.7	-2.1
Irritable Bowel Disease (IBD)	2.2	5.2	6.9	2.1	-2.0	2.6
Relative age voice broke	2.2	3.3	8.7	-1.1	0.1	-3.0
High blood pressure	2.2	6.3	13.8	-3.7	1.4	-1.7
Father’s age at death	2.2	3.0	5.5	2.4	-0.0	1.8
Comparative body size at age 10	2.2	6.1	10.0	-3.2	1.0	-2.7
Worry too long after embarrassment	2.2	3.6	9.1	1.3	-0.3	3.0
Health satisfaction	2.2	2.9	3.6	-1.9	1.8	-1.4
Chest pain or discomfort	2.2	3.2	5.0	-0.7	2.2	-2.0
Hypertension (Self-reported)	2.2	6.2	13.2	-3.6	1.5	-1.8
Smoking status: Previous	2.2	3.3	5.1	-2.2	-1.3	-1.7
Qualifications: nursing, teaching	2.2	3.4	5.7	2.4	-1.9	-0.9
Guilty feelings	2.2	3.2	9.7	0.1	0.1	3.1
Pack years of smoking	2.2	3.2	7.1	-1.6	-0.5	-2.7
Fluid intelligence score	2.1	4.3	11.2	-0.5	-1.2	-3.4
Qualifications: A levels/AS levels or equivalent	2.1	4.5	7.7	2.8	2.0	-1.4
Loud music exposure frequency	2.1	2.3	5.9	-1.0	-0.0	-2.4
Headache pain in last month	2.1	3.5	6.6	-0.0	2.6	-2.0
Chronic bronchitis/emphysema (mother)	2.1	2.5	7.2	-0.1	-0.5	-2.7
Knee pain experienced in last month	2.1	3.2	6.3	-1.8	-0.2	-2.5
Medication: Aspirin	2.1	2.8	3.1	-1.8	1.7	-1.5
Pain experienced in last month	2.1	3.4	9.1	0.8	-0.7	3.0
Supplements: Calcium	2.1	2.3	6.4	0.2	2.5	-0.6
Allergy	2.0	4.6	9.8	-3.1	0.6	1.9
Pain all over the body in last month	2.0	2.1	3.8	-0.9	-1.3	-2.0
Number of full sisters	2.0	2.5	6.0	-0.8	-0.9	-2.5
Myopia	2.0	2.9	7.8	-0.8	-0.7	-2.8
Supplements: Zinc	1.9	2.1	4.8	0.9	0.8	2.2
Illnesses of mother	1.9	2.4	4.3	2.1	1.3	1.1
Blood clot in the leg (DVT)	1.9	2.4	4.8	-0.4	1.5	-2.2
Number of full brothers	1.9	2.4	4.8	-2.2	-1.3	-0.9
Osteoporosis (self-reported)	1.9	2.4	5.0	-2.2	-1.2	-0.9
Arm predicted mass (left)	1.9	9.6	23.6	-4.9	0.8	-2.1
Alzheimer’s Disease (including proxy)	1.8	2.7	5.1	1.6	0.5	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	4.0	0.2	1.8	2.0
Illnesses of father: High blood pressure	1.8	2.2	5.0	-0.7	1.1	-2.2
Ever had prostate specific antigen (PSA) test	1.8	2.0	5.5	0.4	2.3	0.6
Ulcerative Colitis (UC)	1.7	3.1	4.2	2.0	-1.6	1.6
Body Mass Index (BMI) (2010)	1.7	2.3	4.8	0.0	2.2	-1.5
Respiratory disease	1.7	3.8	8.0	1.8	-0.7	-2.8
High blood pressure (mother)	1.7	2.3	5.5	-1.2	-2.4	0.2
Impedance of arm (right)	1.7	7.8	20.0	4.5	0.3	1.9
Arm fat-free mass (left)	1.7	8.9	23.2	-4.8	0.8	-1.6
Risk taking	1.7	2.5	5.5	-0.6	1.2	-2.3
Mean Putamen Volume	1.6	1.8	3.8	0.0	-2.0	1.3
HbA1C	1.6	1.7	3.7	0.0	1.9	-1.2
Waist Hip Ratio (WHR)	1.6	7.3	11.8	3.2	0.0	3.4
Smoking Status	1.6	3.8	7.1	-2.7	-1.2	-1.8
Hayfever, allergic rhinitis or eczema	1.6	3.4	10.0	3.2	0.1	0.4
Had menopause	1.6	2.1	3.3	-1.6	0.5	-1.8
Falls in the last year	1.6	2.2	4.7	-0.2	2.2	-1.4
Impedance of arm (left)	1.6	7.4	18.3	4.3	0.3	1.9
Medication for pain relief, constipation, heartburn	1.6	2.7	5.0	-0.3	-1.8	2.2
Arm predicted mass (right)	1.6	8.4	21.6	-4.7	0.9	-1.7
Unable to work because of sickness or disability	1.6	2.0	4.9	-2.2	-0.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	4.8	-0.5	1.0	-2.2
Crohns Disease (2017)	1.5	3.4	5.4	1.6	-1.5	2.3
Age at First Birth	1.5	2.2	4.8	0.0	2.2	1.4
Blood Eosinophil Count	1.5	11.2	29.9	5.5	-1.0	-1.7
Leg fat-free mass (left)	1.5	7.8	19.9	-4.5	1.5	-1.1
Townsend deprivation index at recruitment	1.5	2.0	3.5	0.2	1.9	-1.6
Number of live births	1.5	2.2	4.7	-2.2	-0.8	1.0
Arm fat-free mass (right)	1.5	7.9	20.7	-4.5	0.7	-1.6
Alcohol intake frequency.	1.5	3.5	9.6	-3.1	0.7	-0.7
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.5	-1.1	0.8	-1.9
Long-standing illness, disability or infirmity	1.5	2.2	6.3	0.7	-0.2	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.1	1.2	-1.1	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	4.3	2.1	0.8	0.5
Impedance of whole body	1.5	7.7	21.2	4.6	-0.4	1.3
Heel T-Score	1.4	10.8	20.6	4.5	-1.5	3.0
Number of treatments/medications taken	1.4	2.5	5.0	-1.1	1.1	-2.2
Pack years adult smoking proportion	1.4	2.2	4.9	-1.3	-0.3	-2.2
Medication: Atenolol	1.4	1.7	2.8	-1.7	-1.3	0.9
Leg predicted mass (left)	1.4	7.6	19.5	-4.4	1.4	-1.1
Past tobacco smoking	1.4	2.5	3.3	1.8	1.3	1.6
Hair/balding pattern: Pattern 3	1.4	2.0	4.4	-1.1	0.6	-2.1
Medication: Omeprazole	1.4	1.7	4.7	2.2	-0.3	0.6
Loneliness, isolation	1.4	2.0	5.7	-0.5	-0.3	2.4
Average weekly champagne plus white wine intake	1.4	1.9	3.2	-1.8	1.1	-1.1
Miserableness	1.4	2.5	6.0	-1.1	0.3	2.4
Medication: Paracetamol	1.4	2.2	3.2	-1.2	1.4	-1.8
Basal metabolic rate	1.4	8.0	21.2	-4.6	1.1	-1.3
Prostate Cancer	1.3	1.9	3.7	1.9	-0.3	1.4
Hand grip strength (left)	1.3	3.3	5.2	-2.2	0.2	-2.3
Relative age of first facial hair	1.3	2.6	5.1	-2.3	-0.3	-1.6
Systolic blood pressure, automated reading	1.3	3.9	7.5	-2.7	2.0	0.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.0	2.0	-0.3	-0.3
Impedance of leg (right)	1.3	6.1	15.8	4.0	-1.6	0.3
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	1.7	1.3	1.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.7	-0.1	0.6	2.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.8	0.9	-0.9	2.2
Leg fat-free mass (right)	1.3	7.2	18.4	-4.3	1.7	-0.7
Leg predicted mass (right)	1.3	7.2	18.2	-4.3	1.7	-0.7
Verbal and Numeric Reasoning (VNR)	1.2	2.9	8.3	0.3	0.6	-2.9
Diabetes (mother)	1.2	1.6	4.2	-2.0	0.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.1	0.7	-0.3	2.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.5	0.8	0.4	1.9
Medication: Paracetamol	1.2	2.0	2.9	-1.0	1.5	-1.7
Pulse wave peak to peak time	1.2	1.5	2.6	0.9	-1.6	1.0
Major Depression (MDD)	1.1	1.3	2.2	0.0	-1.3	1.5
Allergy or Eczema	1.1	3.0	8.6	2.9	-0.3	-0.6
Impedance of leg (left)	1.1	5.4	13.5	3.7	-1.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	3.5	1.9	-1.1	1.7
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	-0.8	1.6	-0.8
Birth weight of first child	1.1	2.0	3.4	-0.5	-1.8	-1.5
Qualifications: College or University degree	1.1	3.6	5.6	2.4	2.2	-0.2
Medication: Ibuprofen	1.1	1.4	2.5	-1.0	1.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.2	-0.7	-1.5	1.2
Whole body fat-free mass	1.1	6.1	16.6	-4.1	1.1	-0.7
Commuting to job workplace: Walk	1.1	1.2	2.8	1.7	-0.7	0.5
Whole body water mass	1.1	6.2	17.0	-4.1	1.1	-0.7
Ever depressed for a whole week	1.1	1.3	2.5	1.1	0.5	1.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.4	1.9	-0.6	-0.3
Intelligence (Savage-Jansen 2018)	1.0	2.9	5.8	1.4	1.1	-2.4
Alzheimer’s Disease (in mother)	1.0	1.2	2.5	1.6	0.4	0.9
HDL Cholesterol	1.0	1.7	3.8	0.0	-1.1	2.0
Hypothyroidism (self reported)	1.0	2.3	5.8	0.3	1.0	2.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-0.0	1.8	-0.9
Qualifications: CSEs or equivalent	1.0	1.3	2.1	-1.3	-0.5	1.5
Alcohol intake versus 10 years previously	1.0	1.5	2.3	-0.1	-1.5	-1.5
Exposure to tobacco smoke at home	1.0	1.1	1.8	-1.4	1.2	0.0
Peak expiratory flow (PEF)	1.0	2.3	4.2	1.2	-1.1	2.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.2	0.3	1.8	1.6
Number of children fathered	1.0	1.1	1.7	-1.3	0.1	-1.3
Illnesses of father: Heart disease	1.0	1.3	2.7	0.9	-0.7	-1.6
Ever smoked	1.0	1.7	2.7	-1.3	-1.6	-0.9
Reaction Time	0.9	1.7	2.7	-1.7	0.2	-1.5
Primary Biliary Cirrhosis	0.9	1.3	3.6	-1.9	0.3	-0.4
Blood White Count	0.9	6.6	16.1	4.0	0.1	1.9
Severe depression (siblings)	0.9	1.0	2.5	1.6	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.1	1.8	-1.7	0.5
Hearing difficulty/problems with background noise	0.9	1.5	3.6	-0.4	-0.9	-1.9
Happiness	0.9	1.1	1.8	1.2	0.2	1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.2	0.2	1.8	0.5
Glaucoma (self-reported)	0.9	1.0	1.6	0.5	-1.1	1.3
Angina (self-reported)	0.9	1.2	2.0	-1.4	-0.3	1.2
Suffer from ‘nerves’	0.9	1.4	2.7	1.2	0.2	1.6
Friendships satisfaction	0.9	1.1	2.0	1.4	0.0	1.2
LDL Cholesterol	0.8	1.3	3.8	0.0	0.4	-1.9
Rheumatoid Arthritis	0.8	1.2	2.2	-0.3	1.1	1.5
Angina	0.8	1.1	1.8	-1.3	-0.3	1.1
Trunk fat-free mass	0.8	4.5	13.0	-3.6	0.6	-0.3
Trunk predicted mass	0.8	4.5	13.0	-3.6	0.6	-0.3
Age at first live birth	0.8	1.4	2.3	1.4	0.4	1.5
Mean time to correctly identify matches	0.8	1.5	2.3	-1.5	0.4	-1.4
Pulse rate, automated reading	0.8	2.6	4.9	0.5	2.2	-1.6
Illnesses of siblings: Diabetes	0.8	0.9	2.1	-0.8	-0.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.0	0.6	0.6	2.0
Eye problems/disorders: Glaucoma	0.8	0.9	2.7	0.1	0.2	1.6
Commuting to job workplace: Cycle	0.8	1.0	2.2	1.5	0.2	-0.8
Lung FEV1/FVC ratio	0.7	3.8	6.4	2.1	-0.8	2.5
Chronotype (morning person)	0.7	1.7	3.0	-1.7	0.8	1.2
Medication for hormone replacement therapy	0.7	0.8	1.8	0.4	1.4	-0.5
Financial difficulties in last 2 years	0.7	1.0	1.3	-1.1	0.6	-1.2
Time employed in main current job	0.7	0.8	1.8	0.5	1.3	0.6
Gout (self-reported)	0.7	0.9	2.7	1.6	-0.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	-1.4	-0.3	0.5
Age at last live birth	0.7	1.0	2.2	0.2	0.9	1.5
Average weekly red wine intake	0.7	1.0	2.0	-0.8	1.4	-0.7
Diabetes diagnosed by doctor	0.7	1.1	2.6	0.4	-0.7	-1.6
Ever taken oral contraceptive pill	0.7	0.8	1.4	0.9	-1.2	-0.0
Medication: Lisinopril	0.7	1.0	2.4	-0.6	1.6	-0.0
Heart disease (siblings)	0.7	0.9	2.6	-1.6	0.0	0.1
Medication: Co-codamol	0.6	0.7	1.6	-0.5	-0.4	-1.3
Hand grip strength (right)	0.6	1.5	2.3	-1.3	0.7	-1.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.9	-0.2	1.4	-0.2
Medication: Levothyroxine sodium	0.6	1.0	1.8	0.2	1.0	1.3
Heart attack	0.6	0.7	1.8	-0.1	0.6	-1.4
Pulse wave reflection index	0.6	0.7	1.8	-1.4	0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.7	1.6	-0.5	-0.1
Medication: Amlodipine	0.6	0.9	1.7	0.8	-0.5	1.3
Shortness of breath walking on level ground	0.6	0.7	1.6	-0.7	-0.1	-1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	-0.6	0.2	1.3
Medication: Blood pressure	0.6	1.1	1.8	-1.3	1.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	0.2	-0.9	-1.2
Commuting to job workplace: Public transport	0.6	0.8	1.7	-0.8	1.3	-0.1
Alcohol drinker status: Never	0.6	0.7	1.8	-0.5	1.3	0.3
Alcohol drinker status: Previous	0.6	0.7	1.2	-1.1	0.8	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.3	0.3	0.3	1.2
Diabetes (father)	0.5	0.7	0.8	0.8	0.7	0.9
Stomach or abdominal pain in last month	0.5	0.6	1.3	1.1	-0.7	-0.3
Had other major operations	0.5	0.6	1.4	-1.2	0.5	0.1
Noisy workplace	0.5	0.7	0.9	0.9	-0.8	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.0	-0.6	1.0	-0.8
Family relationship satisfaction	0.5	0.6	1.1	0.3	0.7	-1.0
Ever had bowel cancer screening	0.5	0.5	1.6	-1.3	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	0.8	-1.1	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	-0.4	0.6	-1.2
Average weekly fortified wine intake	0.4	0.4	1.2	-0.4	0.0	-1.1
Taking other prescription medications	0.4	0.6	1.1	0.9	0.0	-1.1
Supplements: Glucosamine	0.4	0.5	1.1	1.0	-0.1	-0.5
Alcohol usually taken with meals	0.4	0.6	0.9	-0.7	0.6	-1.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	1.1	-0.6	0.1
Pulse rate	0.4	0.7	1.8	0.4	1.3	0.2
Birth weight	0.4	0.9	2.5	-1.6	0.2	0.3
Comparative height size at age 10	0.4	2.4	6.8	2.6	0.1	0.5
Had major operations	0.4	0.5	0.8	-0.2	-0.7	-0.9
Supplements: Vitamin C	0.4	0.4	0.6	0.7	-0.6	0.5
Osteoarthritis (self-reported)	0.4	0.6	1.5	0.3	-1.2	0.3
Medication: Gliclazide	0.4	0.4	0.8	0.9	-0.4	0.5
Wears glasses or contact lenses	0.4	0.5	1.0	-1.0	0.7	0.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	0.4	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.9	0.0	1.4	0.5
Schizophrenia (2018)	0.3	0.7	1.7	0.0	1.3	0.6
Ovarian Cancer	0.3	0.4	0.5	0.7	0.2	0.7
Schizophrenia (2014)	0.3	0.7	1.6	0.0	0.7	1.3
Blood Platelet Count	0.3	3.3	7.2	-1.4	-0.8	-2.7
Systolic Blood Pressure	0.3	1.6	2.5	-0.9	1.6	1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	-1.2	-0.0	-0.1
Average weekly spirits intake	0.3	0.4	1.1	0.1	0.3	-1.0
Current tobacco smoking	0.3	0.5	0.7	-0.4	-0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.6	-0.1	0.7	-0.7
Diabetes (self-reported)	0.3	0.5	0.8	0.1	-0.9	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.2	-0.2	1.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	0.1	0.9	0.4
Medication: Lansoprazole	0.3	0.4	1.1	-0.1	-0.1	-1.1
Neck or shoulder pain in last month	0.3	0.5	1.3	-1.1	-0.0	-0.2
Migraine (self-reported)	0.3	0.3	0.7	0.4	0.8	-0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	-0.3	-0.4	0.9
Eye problems/disorders: Cataract	0.3	0.3	0.4	0.4	0.6	-0.6
Back pain experienced in last month	0.3	0.4	0.7	0.9	0.5	-0.6
Mineral and other dietary supplements	0.3	0.4	1.2	-1.1	-0.0	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	0.7	0.5	0.6
Depression (Nagel 2018)	0.2	0.3	0.6	0.2	0.6	0.8
Fasting Glucose	0.2	0.3	0.3	-0.5	-0.5	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.2	0.8	0.4
Vitamin and mineral supplements	0.2	0.3	0.7	0.8	-0.0	0.5
Medication: Metformin	0.2	0.2	0.4	-0.1	0.6	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.4	0.7	0.5
Age when periods started (menarche)	0.2	0.4	1.3	-0.1	0.1	1.1
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.5	0.3	0.5
Multivitamins +/- minerals	0.2	0.3	0.8	-0.9	-0.1	0.0
Length of working week for main job	0.2	0.3	0.6	-0.8	0.3	0.3
Breastfed as a baby	0.2	0.3	0.7	-0.1	0.3	-0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.3	0.1	-0.8
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.0	0.7	-0.4
Heart disease (mother)	0.2	0.2	0.4	-0.3	-0.6	0.4
Average weekly beer plus cider intake	0.2	0.2	0.5	0.7	-0.5	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.0	-0.3	0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.0	0.0	-0.5
Height	0.1	1.7	2.7	-1.6	0.2	1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	-0.2	0.4
Maternal smoking around birth	0.1	0.1	0.3	0.3	-0.1	-0.6
Sitting height	0.1	0.6	1.3	1.2	0.3	0.5
Mouth/teeth dental problems	0.1	0.2	0.4	0.5	-0.0	0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.5	-0.2	0.4
Standing height	0.1	1.5	3.1	0.9	0.8	1.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.9	0.3	0.3
Eye problems/disorders: None of the above	0.1	0.2	0.4	-0.6	0.2	0.3
Breast cancer (self-reported)	0.1	0.1	0.2	0.1	0.4	-0.2
Smoking status: Current	0.1	0.2	0.4	-0.0	-0.7	-0.5
Mother’s age at death	0.1	0.1	0.4	-0.1	-0.6	0.0
Financial situation satisfaction	0.1	0.1	0.3	-0.6	0.1	0.2
Number of operations (self-reported)	0.1	0.1	0.3	-0.1	-0.1	-0.5
Age started oral contraceptive pill	0.1	0.1	0.4	-0.2	-0.6	0.1
Bipolar Disorder (2018)	0.0	0.1	0.2	0.0	0.5	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	-0.3
Crohns Disease (2012)	0.0	0.0	0.1	0.0	0.0	0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	-0.2
Hair Pigment	0.0	0.9	1.8	1.4	0.2	0.8
Tanning	0.0	0.5	1.0	0.5	-1.0	-0.4
Qualifications: None of the above	0.0	0.0	0.1	-0.3	0.2	-0.0
Depression (self-reported)	0.0	0.0	0.0	0.1	-0.0	0.0

Hub : Genes

BCL7C

Models

Trait associations