Best TWAS P=2.18e-08 · Best GWAS P=3.22e-08 conditioned to 0.0802
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CTD-2514C3.1 | 0.06 | 0.02 | enet | 5 | 0.04 | 6.1e-04 | -3.5 | 5.2 | 1.6e-07 | -0.73 | 0.02 | 0.96 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | ABHD12 | 0.09 | 0.05 | enet | 13 | 0.04 | 2.9e-02 | -5.3 | -5.5 | 3.2e-08 | 0.95 | 0.06 | 0.82 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | ENTPD6 | 0.22 | 0.26 | lasso | 3 | 0.17 | 3.8e-05 | -5.0 | 5.2 | 2.5e-07 | -0.82 | 0.12 | 0.86 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ABHD12 | 0.24 | 0.33 | lasso | 4 | 0.35 | 6.3e-27 | -5.3 | -5.4 | 8.1e-08 | 0.90 | 0.07 | 0.93 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | GINS1 | 0.04 | 0.01 | lasso | 3 | 0.01 | 5.2e-02 | -4.3 | -5.3 | 9.8e-08 | 0.73 | 0.13 | 0.78 | FALSE |
6 | GTEx | Colon Sigmoid | ABHD12 | 0.17 | 0.17 | lasso | 15 | 0.17 | 1.0e-06 | -5.3 | -5.4 | 6.0e-08 | 0.99 | 0.05 | 0.94 | FALSE |
7 | GTEx | Heart Atrial Appendage | ABHD12 | 0.07 | 0.06 | enet | 16 | 0.06 | 1.0e-03 | -5.2 | -5.2 | 2.2e-07 | 0.89 | 0.09 | 0.89 | FALSE |
8 | GTEx | Heart Left Ventricle | ABHD12 | 0.15 | 0.14 | lasso | 10 | 0.12 | 4.0e-07 | -5.1 | -5.2 | 2.0e-07 | 0.87 | 0.11 | 0.89 | FALSE |
9 | GTEx | Liver | ABHD12 | 0.20 | 0.20 | lasso | 19 | 0.15 | 7.3e-05 | -5.2 | -5.5 | 3.9e-08 | 0.87 | 0.10 | 0.90 | FALSE |
10 | GTEx | Muscle Skeletal | ENTPD6 | 0.04 | 0.02 | lasso | 4 | 0.01 | 1.5e-02 | -4.9 | 5.2 | 2.4e-07 | -0.87 | 0.08 | 0.87 | FALSE |
11 | GTEx | Nerve Tibial | ABHD12 | 0.24 | 0.44 | lasso | 11 | 0.44 | 5.1e-34 | -5.2 | 5.2 | 2.0e-07 | -0.86 | 0.12 | 0.88 | FALSE |
12 | GTEx | Ovary | ABHD12 | 0.23 | 0.04 | lasso | 8 | 0.05 | 1.9e-02 | -5.1 | -5.6 | 2.2e-08 | 0.80 | 0.08 | 0.63 | TRUE |
13 | GTEx | Spleen | PYGB | 0.15 | 0.09 | lasso | 6 | 0.04 | 2.6e-02 | -5.2 | -5.5 | 3.7e-08 | 0.84 | 0.10 | 0.78 | FALSE |
14 | GTEx | Thyroid | ABHD12 | 0.05 | 0.04 | lasso | 5 | 0.03 | 3.9e-03 | -4.9 | 5.3 | 1.4e-07 | -0.88 | 0.10 | 0.86 | FALSE |
15 | GTEx | Thyroid | NINL | 0.13 | 0.18 | enet | 17 | 0.20 | 6.2e-15 | 4.0 | 5.2 | 2.1e-07 | -0.83 | 0.31 | 0.69 | FALSE |
16 | GTEx | Thyroid | VN1R108P | 0.05 | 0.01 | lasso | 2 | 0.02 | 1.8e-02 | -4.3 | -5.3 | 1.1e-07 | 0.77 | 0.10 | 0.71 | FALSE |
17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABHD12 | 0.04 | 0.00 | blup | 77 | 0.02 | 6.6e-03 | -5.1 | -5.3 | 1.5e-07 | 0.89 | 0.04 | 0.56 | FALSE |
18 | The Cancer Genome Atlas | Glioblastoma Multiforme | ABHD12 | 0.14 | 0.10 | lasso | 5 | 0.13 | 1.1e-04 | -5.3 | -5.5 | 4.2e-08 | 0.98 | 0.05 | 0.91 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABHD12 | 0.04 | 0.03 | blup | 77 | 0.04 | 4.0e-05 | -5.1 | -5.3 | 9.6e-08 | 0.89 | 0.06 | 0.94 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABHD12 | 0.04 | 0.06 | blup | 77 | 0.06 | 2.2e-07 | -5.1 | -5.2 | 2.1e-07 | 0.92 | 0.06 | 0.94 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABHD12 | 0.03 | 0.02 | lasso | 4 | 0.03 | 5.8e-04 | 4.9 | -5.2 | 1.7e-07 | 0.96 | 0.04 | 0.84 | FALSE |
22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NINL | 0.11 | 0.03 | blup | 81 | 0.07 | 2.1e-03 | 5.2 | 5.5 | 4.9e-08 | -0.89 | 0.03 | 0.72 | FALSE |