Best TWAS P=7.92e-13 · Best GWAS P=1.23e-20 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | WHAMM | 0.46 | 0.45 | lasso | 3 | 0.47 | 2.7e-42 | -4.97 | 5.5 | 4.8e-08 | -0.12 | 0.22 | 0.78 | FALSE |
2 | GTEx | Adipose Subcutaneous | RP11-182J1.14 | 0.11 | 0.11 | lasso | 9 | 0.12 | 8.1e-10 | 4.70 | 5.4 | 6.6e-08 | -0.46 | 1.00 | 0.00 | FALSE |
3 | GTEx | Artery Tibial | SCAND2P | 0.12 | 0.05 | enet | 16 | 0.08 | 8.7e-07 | -3.96 | -5.4 | 8.2e-08 | 0.39 | 0.33 | 0.50 | FALSE |
4 | GTEx | Artery Tibial | AC103965.1 | 0.27 | 0.26 | enet | 31 | 0.30 | 1.8e-23 | 4.70 | -7.2 | 7.9e-13 | 0.56 | 1.00 | 0.00 | TRUE |
5 | GTEx | Artery Tibial | CSPG4P11 | 0.16 | 0.24 | lasso | 4 | 0.23 | 3.0e-18 | 4.70 | -5.9 | 4.3e-09 | 0.54 | 1.00 | 0.00 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | UBE2Q2P1 | 0.18 | 0.08 | enet | 18 | 0.12 | 4.2e-04 | 5.44 | 6.0 | 2.4e-09 | -0.45 | 0.18 | 0.18 | TRUE |
7 | GTEx | Brain Cerebellar Hemisphere | CSPG4P11 | 0.30 | 0.21 | lasso | 3 | 0.16 | 7.6e-05 | 5.13 | 5.2 | 1.9e-07 | -0.44 | 0.39 | 0.08 | FALSE |
8 | GTEx | Brain Cerebellum | AC103965.1 | 0.13 | 0.02 | enet | 21 | 0.01 | 2.1e-01 | 4.83 | -6.9 | 4.4e-12 | 0.67 | 0.04 | 0.71 | TRUE |
9 | GTEx | Brain Cortex | AC103965.1 | 0.17 | 0.19 | lasso | 3 | 0.16 | 4.3e-05 | 4.68 | -5.2 | 2.0e-07 | 0.46 | 0.21 | 0.45 | FALSE |
10 | GTEx | Brain Cortex | RP11-182J1.14 | 0.24 | 0.03 | enet | 14 | 0.16 | 3.2e-05 | 5.21 | 6.8 | 1.1e-11 | -0.46 | 0.07 | 0.22 | FALSE |
11 | GTEx | Brain Hippocampus | GOLGA6L5 | 0.41 | 0.05 | enet | 35 | 0.15 | 2.2e-04 | -3.11 | -5.2 | 1.6e-07 | 0.14 | 0.33 | 0.04 | TRUE |
12 | GTEx | Breast Mammary Tissue | WHAMM | 0.18 | 0.18 | enet | 10 | 0.09 | 1.8e-05 | -4.97 | 5.1 | 2.9e-07 | -0.13 | 0.21 | 0.79 | FALSE |
13 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 4.68 | -5.7 | 1.3e-08 | 0.53 | 0.12 | 0.29 | FALSE |
14 | GTEx | Breast Mammary Tissue (Male) | RN7SL417P | 0.20 | 0.12 | lasso | 3 | 0.10 | 3.1e-03 | 5.44 | 5.4 | 8.7e-08 | -0.46 | 0.06 | 0.12 | FALSE |
15 | GTEx | Breast Mammary Tissue (Male) | RP11-182J1.14 | 0.04 | -0.01 | enet | 1 | -0.01 | 5.9e-01 | 5.19 | 5.2 | 2.1e-07 | -0.43 | 0.03 | 0.08 | FALSE |
16 | GTEx | Breast Mammary Tissue (Male) | CSPG4P11 | 0.05 | 0.02 | lasso | 6 | 0.03 | 7.1e-02 | 5.56 | -6.1 | 1.1e-09 | 0.44 | 0.03 | 0.09 | TRUE |
17 | GTEx | Cells Transformed fibroblasts | SCAND2P | 0.29 | 0.20 | enet | 39 | 0.21 | 6.5e-16 | -3.96 | -5.4 | 5.2e-08 | 0.32 | 0.88 | 0.09 | TRUE |
18 | GTEx | Colon Sigmoid | RN7SL417P | 0.17 | 0.06 | lasso | 4 | 0.12 | 6.1e-05 | 5.19 | 5.3 | 1.1e-07 | -0.46 | 0.28 | 0.09 | FALSE |
19 | GTEx | Colon Sigmoid | RP11-182J1.14 | 0.31 | 0.29 | lasso | 9 | 0.30 | 2.7e-11 | 5.21 | 5.3 | 1.5e-07 | -0.46 | 1.00 | 0.00 | TRUE |
20 | GTEx | Colon Transverse | RP11-182J1.14 | 0.23 | 0.19 | enet | 27 | 0.18 | 3.9e-09 | 4.83 | 5.6 | 2.4e-08 | -0.46 | 1.00 | 0.00 | TRUE |
21 | GTEx | Esophagus Gastroesophageal Junction | AC103965.1 | 0.13 | 0.14 | lasso | 4 | 0.15 | 3.2e-06 | 5.19 | -5.6 | 2.7e-08 | 0.42 | 0.48 | 0.06 | FALSE |
22 | GTEx | Esophagus Gastroesophageal Junction | CSPG4P11 | 0.18 | 0.06 | lasso | 2 | 0.06 | 3.5e-03 | 5.13 | -5.6 | 2.1e-08 | 0.43 | 0.23 | 0.04 | FALSE |
23 | GTEx | Esophagus Gastroesophageal Junction | RP11-382A20.2 | 0.13 | 0.03 | enet | 20 | 0.07 | 1.1e-03 | 3.60 | 5.9 | 3.1e-09 | -0.12 | 0.11 | 0.14 | TRUE |
24 | GTEx | Esophagus Mucosa | AC103965.1 | 0.20 | 0.19 | enet | 47 | 0.16 | 8.4e-11 | 4.70 | -5.6 | 1.7e-08 | 0.38 | 1.00 | 0.00 | FALSE |
25 | GTEx | Esophagus Muscularis | AC103965.1 | 0.18 | 0.14 | enet | 16 | 0.14 | 7.6e-09 | 5.13 | -5.1 | 2.9e-07 | 0.46 | 1.00 | 0.00 | FALSE |
26 | GTEx | Heart Atrial Appendage | RP11-182J1.14 | 0.06 | 0.05 | lasso | 3 | 0.05 | 3.6e-03 | 5.21 | 5.2 | 1.9e-07 | -0.44 | 0.17 | 0.24 | FALSE |
27 | GTEx | Nerve Tibial | AC103965.1 | 0.20 | 0.22 | enet | 17 | 0.27 | 5.1e-19 | 4.70 | -6.3 | 2.8e-10 | 0.58 | 1.00 | 0.00 | FALSE |
28 | GTEx | Pancreas | AC103965.1 | 0.29 | 0.23 | lasso | 9 | 0.18 | 2.8e-08 | 4.83 | -5.4 | 5.5e-08 | 0.44 | 1.00 | 0.00 | FALSE |
29 | GTEx | Pituitary | AC103965.1 | 0.30 | 0.16 | enet | 10 | 0.24 | 8.4e-07 | 4.47 | -5.4 | 8.2e-08 | 0.45 | 0.40 | 0.22 | TRUE |
30 | GTEx | Prostate | RP11-182J1.16 | 0.24 | 0.06 | enet | 27 | 0.08 | 6.2e-03 | 0.49 | -5.8 | 7.5e-09 | 0.48 | 0.09 | 0.10 | TRUE |
31 | GTEx | Prostate | RP11-182J1.14 | 0.25 | 0.09 | enet | 25 | 0.09 | 2.9e-03 | 5.16 | 5.7 | 1.3e-08 | -0.35 | 0.19 | 0.08 | FALSE |
32 | GTEx | Skin Sun Exposed Lower leg | AC103965.1 | 0.33 | 0.17 | enet | 24 | 0.23 | 4.8e-19 | 4.70 | -5.2 | 1.9e-07 | 0.45 | 1.00 | 0.00 | FALSE |
33 | GTEx | Small Intestine Terminal Ileum | RP11-182J1.14 | 0.26 | 0.01 | enet | 27 | 0.12 | 1.3e-03 | -9.23 | 7.1 | 1.2e-12 | -0.61 | 0.02 | 0.62 | FALSE |
34 | GTEx | Stomach | AC103965.1 | 0.14 | 0.11 | lasso | 3 | 0.10 | 1.1e-05 | 4.68 | -5.3 | 1.1e-07 | 0.40 | 0.84 | 0.01 | FALSE |
35 | METSIM | Adipose | WHAMM | 0.35 | 0.30 | lasso | 2 | 0.30 | 4.0e-46 | -5.26 | 5.3 | 1.5e-07 | -0.14 | 0.06 | 0.94 | FALSE |
36 | The Cancer Genome Atlas | Glioblastoma Multiforme | GOLGA6L5 | 0.20 | 0.05 | blup | 7 | 0.07 | 4.7e-03 | -4.37 | -5.2 | 2.0e-07 | 0.35 | 0.00 | 0.13 | TRUE |
37 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZSCAN2 | 0.11 | 0.00 | blup | 46 | 0.03 | 1.2e-04 | 2.94 | 6.1 | 9.7e-10 | -0.25 | 0.01 | 0.24 | FALSE |
38 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GOLGA6L5 | 0.04 | 0.01 | blup | 7 | 0.03 | 4.9e-04 | 4.85 | -5.5 | 4.1e-08 | 0.44 | 0.00 | 0.87 | TRUE |
39 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADAMTSL3 | 0.03 | 0.02 | blup | 153 | 0.01 | 7.6e-03 | 5.56 | -5.3 | 1.1e-07 | 0.43 | 0.36 | 0.07 | FALSE |
40 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | WHAMM | 0.14 | 0.05 | enet | 11 | 0.08 | 1.0e-04 | -5.26 | 6.1 | 1.2e-09 | -0.15 | 0.01 | 0.98 | TRUE |
41 | The Cancer Genome Atlas | Rectum Adenocarcinoma | WHAMM | 0.25 | 0.06 | blup | 55 | 0.09 | 4.2e-03 | -5.26 | 5.4 | 7.1e-08 | -0.12 | 0.01 | 0.76 | FALSE |
42 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | WHAMM | 0.14 | 0.17 | enet | 5 | 0.13 | 2.5e-04 | -5.48 | -5.7 | 1.4e-08 | 0.00 | 0.01 | 0.61 | FALSE |