[Hub]/) : Traits : Forced vital capacity (FVC), Best measure :

chr15:83,167,559-85,883,064

Best TWAS P=7.92e-13 · Best GWAS P=1.23e-20 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous WHAMM 0.46 0.45 lasso 3 0.47 2.7e-42 -4.97 5.5 4.8e-08 -0.12 0.22 0.78 FALSE
2 GTEx Adipose Subcutaneous RP11-182J1.14 0.11 0.11 lasso 9 0.12 8.1e-10 4.70 5.4 6.6e-08 -0.46 1.00 0.00 FALSE
3 GTEx Artery Tibial SCAND2P 0.12 0.05 enet 16 0.08 8.7e-07 -3.96 -5.4 8.2e-08 0.39 0.33 0.50 FALSE
4 GTEx Artery Tibial AC103965.1 0.27 0.26 enet 31 0.30 1.8e-23 4.70 -7.2 7.9e-13 0.56 1.00 0.00 TRUE
5 GTEx Artery Tibial CSPG4P11 0.16 0.24 lasso 4 0.23 3.0e-18 4.70 -5.9 4.3e-09 0.54 1.00 0.00 FALSE
6 GTEx Brain Cerebellar Hemisphere UBE2Q2P1 0.18 0.08 enet 18 0.12 4.2e-04 5.44 6.0 2.4e-09 -0.45 0.18 0.18 TRUE
7 GTEx Brain Cerebellar Hemisphere CSPG4P11 0.30 0.21 lasso 3 0.16 7.6e-05 5.13 5.2 1.9e-07 -0.44 0.39 0.08 FALSE
8 GTEx Brain Cerebellum AC103965.1 0.13 0.02 enet 21 0.01 2.1e-01 4.83 -6.9 4.4e-12 0.67 0.04 0.71 TRUE
9 GTEx Brain Cortex AC103965.1 0.17 0.19 lasso 3 0.16 4.3e-05 4.68 -5.2 2.0e-07 0.46 0.21 0.45 FALSE
10 GTEx Brain Cortex RP11-182J1.14 0.24 0.03 enet 14 0.16 3.2e-05 5.21 6.8 1.1e-11 -0.46 0.07 0.22 FALSE
11 GTEx Brain Hippocampus GOLGA6L5 0.41 0.05 enet 35 0.15 2.2e-04 -3.11 -5.2 1.6e-07 0.14 0.33 0.04 TRUE
12 GTEx Breast Mammary Tissue WHAMM 0.18 0.18 enet 10 0.09 1.8e-05 -4.97 5.1 2.9e-07 -0.13 0.21 0.79 FALSE
13 GTEx Breast Mammary Tissue (Male) AC103965.1 0.24 0.14 lasso 4 0.11 1.4e-03 4.68 -5.7 1.3e-08 0.53 0.12 0.29 FALSE
14 GTEx Breast Mammary Tissue (Male) RN7SL417P 0.20 0.12 lasso 3 0.10 3.1e-03 5.44 5.4 8.7e-08 -0.46 0.06 0.12 FALSE
15 GTEx Breast Mammary Tissue (Male) RP11-182J1.14 0.04 -0.01 enet 1 -0.01 5.9e-01 5.19 5.2 2.1e-07 -0.43 0.03 0.08 FALSE
16 GTEx Breast Mammary Tissue (Male) CSPG4P11 0.05 0.02 lasso 6 0.03 7.1e-02 5.56 -6.1 1.1e-09 0.44 0.03 0.09 TRUE
17 GTEx Cells Transformed fibroblasts SCAND2P 0.29 0.20 enet 39 0.21 6.5e-16 -3.96 -5.4 5.2e-08 0.32 0.88 0.09 TRUE
18 GTEx Colon Sigmoid RN7SL417P 0.17 0.06 lasso 4 0.12 6.1e-05 5.19 5.3 1.1e-07 -0.46 0.28 0.09 FALSE
19 GTEx Colon Sigmoid RP11-182J1.14 0.31 0.29 lasso 9 0.30 2.7e-11 5.21 5.3 1.5e-07 -0.46 1.00 0.00 TRUE
20 GTEx Colon Transverse RP11-182J1.14 0.23 0.19 enet 27 0.18 3.9e-09 4.83 5.6 2.4e-08 -0.46 1.00 0.00 TRUE
21 GTEx Esophagus Gastroesophageal Junction AC103965.1 0.13 0.14 lasso 4 0.15 3.2e-06 5.19 -5.6 2.7e-08 0.42 0.48 0.06 FALSE
22 GTEx Esophagus Gastroesophageal Junction CSPG4P11 0.18 0.06 lasso 2 0.06 3.5e-03 5.13 -5.6 2.1e-08 0.43 0.23 0.04 FALSE
23 GTEx Esophagus Gastroesophageal Junction RP11-382A20.2 0.13 0.03 enet 20 0.07 1.1e-03 3.60 5.9 3.1e-09 -0.12 0.11 0.14 TRUE
24 GTEx Esophagus Mucosa AC103965.1 0.20 0.19 enet 47 0.16 8.4e-11 4.70 -5.6 1.7e-08 0.38 1.00 0.00 FALSE
25 GTEx Esophagus Muscularis AC103965.1 0.18 0.14 enet 16 0.14 7.6e-09 5.13 -5.1 2.9e-07 0.46 1.00 0.00 FALSE
26 GTEx Heart Atrial Appendage RP11-182J1.14 0.06 0.05 lasso 3 0.05 3.6e-03 5.21 5.2 1.9e-07 -0.44 0.17 0.24 FALSE
27 GTEx Nerve Tibial AC103965.1 0.20 0.22 enet 17 0.27 5.1e-19 4.70 -6.3 2.8e-10 0.58 1.00 0.00 FALSE
28 GTEx Pancreas AC103965.1 0.29 0.23 lasso 9 0.18 2.8e-08 4.83 -5.4 5.5e-08 0.44 1.00 0.00 FALSE
29 GTEx Pituitary AC103965.1 0.30 0.16 enet 10 0.24 8.4e-07 4.47 -5.4 8.2e-08 0.45 0.40 0.22 TRUE
30 GTEx Prostate RP11-182J1.16 0.24 0.06 enet 27 0.08 6.2e-03 0.49 -5.8 7.5e-09 0.48 0.09 0.10 TRUE
31 GTEx Prostate RP11-182J1.14 0.25 0.09 enet 25 0.09 2.9e-03 5.16 5.7 1.3e-08 -0.35 0.19 0.08 FALSE
32 GTEx Skin Sun Exposed Lower leg AC103965.1 0.33 0.17 enet 24 0.23 4.8e-19 4.70 -5.2 1.9e-07 0.45 1.00 0.00 FALSE
33 GTEx Small Intestine Terminal Ileum RP11-182J1.14 0.26 0.01 enet 27 0.12 1.3e-03 -9.23 7.1 1.2e-12 -0.61 0.02 0.62 FALSE
34 GTEx Stomach AC103965.1 0.14 0.11 lasso 3 0.10 1.1e-05 4.68 -5.3 1.1e-07 0.40 0.84 0.01 FALSE
35 METSIM Adipose WHAMM 0.35 0.30 lasso 2 0.30 4.0e-46 -5.26 5.3 1.5e-07 -0.14 0.06 0.94 FALSE
36 The Cancer Genome Atlas Glioblastoma Multiforme GOLGA6L5 0.20 0.05 blup 7 0.07 4.7e-03 -4.37 -5.2 2.0e-07 0.35 0.00 0.13 TRUE
37 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZSCAN2 0.11 0.00 blup 46 0.03 1.2e-04 2.94 6.1 9.7e-10 -0.25 0.01 0.24 FALSE
38 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GOLGA6L5 0.04 0.01 blup 7 0.03 4.9e-04 4.85 -5.5 4.1e-08 0.44 0.00 0.87 TRUE
39 The Cancer Genome Atlas Brain Lower Grade Glioma ADAMTSL3 0.03 0.02 blup 153 0.01 7.6e-03 5.56 -5.3 1.1e-07 0.43 0.36 0.07 FALSE
40 The Cancer Genome Atlas Liver Hepatocellular Carcinoma WHAMM 0.14 0.05 enet 11 0.08 1.0e-04 -5.26 6.1 1.2e-09 -0.15 0.01 0.98 TRUE
41 The Cancer Genome Atlas Rectum Adenocarcinoma WHAMM 0.25 0.06 blup 55 0.09 4.2e-03 -5.26 5.4 7.1e-08 -0.12 0.01 0.76 FALSE
42 The Cancer Genome Atlas Skin Cutaneous Melanoma WHAMM 0.14 0.17 enet 5 0.13 2.5e-04 -5.48 -5.7 1.4e-08 0.00 0.01 0.61 FALSE