[Hub]/) : Traits : Forced vital capacity (FVC), Best measure :

chr5:139,323,257-141,214,127

Best TWAS P=1.76e-09 · Best GWAS P=1.05e-07 conditioned to 0.354

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NDUFA2 0.02 0.01 bslmm 343 0.01 7.8e-03 -5.2 5.4 7.9e-08 -0.89 0.08 0.69 FALSE
2 CommonMind Brain Pre-frontal Cortex PCDHA2 0.04 0.03 blup 478 0.03 5.0e-05 -5.1 -5.3 1.5e-07 0.84 0.08 0.92 FALSE
3 CommonMind Brain Pre-frontal Cortex PCDHA7 0.13 0.14 lasso 8 0.14 5.1e-17 -5.2 -5.2 2.0e-07 0.97 0.05 0.95 FALSE
4 CommonMind Brain Pre-frontal Cortex ZMAT2 0.06 0.10 blup 360 0.09 1.4e-11 -5.1 -5.9 3.8e-09 0.86 0.07 0.93 FALSE
5 GTEx Artery Tibial TMCO6 0.04 0.04 enet 5 0.04 4.1e-04 4.5 -5.2 1.9e-07 0.80 0.12 0.87 FALSE
6 GTEx Brain Cerebellar Hemisphere WDR55 0.11 0.07 enet 10 -0.01 6.6e-01 -4.6 -5.3 1.3e-07 0.88 0.08 0.61 FALSE
7 GTEx Brain Hypothalamus HARS 0.14 -0.01 enet 15 -0.01 6.3e-01 4.8 5.1 2.8e-07 -0.69 0.06 0.37 FALSE
8 GTEx Cells Transformed fibroblasts WDR55 0.05 0.08 lasso 13 0.07 4.0e-06 -5.1 -5.2 1.9e-07 0.91 0.08 0.92 FALSE
9 GTEx Cells Transformed fibroblasts ZMAT2 0.04 0.02 lasso 4 0.02 2.4e-02 -5.3 -5.4 5.1e-08 0.96 0.06 0.86 FALSE
10 GTEx Esophagus Mucosa ZMAT2 0.06 0.02 enet 16 0.02 1.1e-02 4.8 -5.4 6.5e-08 0.77 0.08 0.81 FALSE
11 GTEx Heart Left Ventricle TMCO6 0.05 0.01 lasso 5 0.00 6.2e-01 -5.1 -5.4 5.4e-08 0.91 0.06 0.74 FALSE
12 GTEx Heart Left Ventricle PCDHB5 0.11 0.05 lasso 3 0.06 5.3e-04 4.6 6.0 1.8e-09 -0.79 0.07 0.76 TRUE
13 GTEx Nerve Tibial HARS 0.07 0.01 enet 16 0.04 1.1e-03 -5.3 5.4 6.9e-08 -0.84 0.06 0.90 FALSE
14 GTEx Vagina IK 0.27 0.09 enet 29 0.15 2.4e-04 -4.5 -5.1 2.7e-07 0.82 0.10 0.85 FALSE
15 METSIM Adipose DND1 0.08 0.11 lasso 5 0.10 7.3e-15 -5.3 5.3 9.5e-08 -0.97 0.06 0.94 FALSE
16 ROSMAP Brain Pre-frontal Cortex PCDHA8 0.04 0.03 enet 4 0.03 3.4e-05 -5.1 -5.3 1.2e-07 0.87 0.04 0.96 FALSE
17 YFS Blood WDR55 0.15 0.21 bslmm 337 0.21 8.6e-67 -5.1 -5.1 2.8e-07 0.90 0.08 0.92 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma PCDHA4 0.01 0.02 lasso 1 0.01 4.9e-04 -5.3 -5.3 1.1e-07 0.99 0.00 0.96 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PCDHA7 0.02 0.02 enet 5 0.02 1.6e-03 5.0 -5.1 2.7e-07 0.60 0.01 0.66 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma PCDHA13 0.07 0.06 blup 29 0.09 8.6e-11 4.7 5.1 2.9e-07 -0.66 0.02 0.96 FALSE
21 The Cancer Genome Atlas Lung Adenocarcinoma PCDHA13 0.02 0.01 enet 11 0.02 5.6e-03 4.7 5.4 6.8e-08 -0.64 0.02 0.77 FALSE
22 The Cancer Genome Atlas Prostate Adenocarcinoma ZMAT2 0.03 0.03 enet 6 0.04 1.3e-04 -5.0 -5.2 1.9e-07 0.89 0.02 0.89 FALSE