Best TWAS P=1.76e-09 · Best GWAS P=1.05e-07 conditioned to 0.354
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NDUFA2 | 0.02 | 0.01 | bslmm | 343 | 0.01 | 7.8e-03 | -5.2 | 5.4 | 7.9e-08 | -0.89 | 0.08 | 0.69 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PCDHA2 | 0.04 | 0.03 | blup | 478 | 0.03 | 5.0e-05 | -5.1 | -5.3 | 1.5e-07 | 0.84 | 0.08 | 0.92 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PCDHA7 | 0.13 | 0.14 | lasso | 8 | 0.14 | 5.1e-17 | -5.2 | -5.2 | 2.0e-07 | 0.97 | 0.05 | 0.95 | FALSE |
4 | CommonMind | Brain Pre-frontal Cortex | ZMAT2 | 0.06 | 0.10 | blup | 360 | 0.09 | 1.4e-11 | -5.1 | -5.9 | 3.8e-09 | 0.86 | 0.07 | 0.93 | FALSE |
5 | GTEx | Artery Tibial | TMCO6 | 0.04 | 0.04 | enet | 5 | 0.04 | 4.1e-04 | 4.5 | -5.2 | 1.9e-07 | 0.80 | 0.12 | 0.87 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | WDR55 | 0.11 | 0.07 | enet | 10 | -0.01 | 6.6e-01 | -4.6 | -5.3 | 1.3e-07 | 0.88 | 0.08 | 0.61 | FALSE |
7 | GTEx | Brain Hypothalamus | HARS | 0.14 | -0.01 | enet | 15 | -0.01 | 6.3e-01 | 4.8 | 5.1 | 2.8e-07 | -0.69 | 0.06 | 0.37 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | WDR55 | 0.05 | 0.08 | lasso | 13 | 0.07 | 4.0e-06 | -5.1 | -5.2 | 1.9e-07 | 0.91 | 0.08 | 0.92 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | ZMAT2 | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | -5.3 | -5.4 | 5.1e-08 | 0.96 | 0.06 | 0.86 | FALSE |
10 | GTEx | Esophagus Mucosa | ZMAT2 | 0.06 | 0.02 | enet | 16 | 0.02 | 1.1e-02 | 4.8 | -5.4 | 6.5e-08 | 0.77 | 0.08 | 0.81 | FALSE |
11 | GTEx | Heart Left Ventricle | TMCO6 | 0.05 | 0.01 | lasso | 5 | 0.00 | 6.2e-01 | -5.1 | -5.4 | 5.4e-08 | 0.91 | 0.06 | 0.74 | FALSE |
12 | GTEx | Heart Left Ventricle | PCDHB5 | 0.11 | 0.05 | lasso | 3 | 0.06 | 5.3e-04 | 4.6 | 6.0 | 1.8e-09 | -0.79 | 0.07 | 0.76 | TRUE |
13 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -5.3 | 5.4 | 6.9e-08 | -0.84 | 0.06 | 0.90 | FALSE |
14 | GTEx | Vagina | IK | 0.27 | 0.09 | enet | 29 | 0.15 | 2.4e-04 | -4.5 | -5.1 | 2.7e-07 | 0.82 | 0.10 | 0.85 | FALSE |
15 | METSIM | Adipose | DND1 | 0.08 | 0.11 | lasso | 5 | 0.10 | 7.3e-15 | -5.3 | 5.3 | 9.5e-08 | -0.97 | 0.06 | 0.94 | FALSE |
16 | ROSMAP | Brain Pre-frontal Cortex | PCDHA8 | 0.04 | 0.03 | enet | 4 | 0.03 | 3.4e-05 | -5.1 | -5.3 | 1.2e-07 | 0.87 | 0.04 | 0.96 | FALSE |
17 | YFS | Blood | WDR55 | 0.15 | 0.21 | bslmm | 337 | 0.21 | 8.6e-67 | -5.1 | -5.1 | 2.8e-07 | 0.90 | 0.08 | 0.92 | FALSE |
18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCDHA4 | 0.01 | 0.02 | lasso | 1 | 0.01 | 4.9e-04 | -5.3 | -5.3 | 1.1e-07 | 0.99 | 0.00 | 0.96 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PCDHA7 | 0.02 | 0.02 | enet | 5 | 0.02 | 1.6e-03 | 5.0 | -5.1 | 2.7e-07 | 0.60 | 0.01 | 0.66 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCDHA13 | 0.07 | 0.06 | blup | 29 | 0.09 | 8.6e-11 | 4.7 | 5.1 | 2.9e-07 | -0.66 | 0.02 | 0.96 | FALSE |
21 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCDHA13 | 0.02 | 0.01 | enet | 11 | 0.02 | 5.6e-03 | 4.7 | 5.4 | 6.8e-08 | -0.64 | 0.02 | 0.77 | FALSE |
22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZMAT2 | 0.03 | 0.03 | enet | 6 | 0.04 | 1.3e-04 | -5.0 | -5.2 | 1.9e-07 | 0.89 | 0.02 | 0.89 | FALSE |