[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted : →

chr1:16,273,995-18,074,702

Best TWAS P=1.33e-12 · Best GWAS P=8.79e-12 conditioned to 0.107

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SDHB	0.03	0.02	blup	361	0.02	3.1e-03	-4.7	5.7	9.5e-09	-0.60	0.15	0.27	FALSE
2	GTEx	Adipose Visceral Omentum	MST1L	0.15	0.08	enet	21	0.11	1.7e-06	4.5	-5.6	2.2e-08	0.87	0.01	0.99	FALSE
3	GTEx	Artery Aorta	MST1L	0.23	0.16	enet	23	0.19	7.0e-11	-4.3	-5.3	1.4e-07	0.66	0.88	0.12	FALSE
4	GTEx	Brain Cerebellum	MST1L	0.21	0.13	lasso	2	0.09	1.7e-03	4.9	-5.1	3.0e-07	0.85	0.03	0.81	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	MST1L	0.31	0.10	lasso	6	0.14	2.2e-05	-6.4	-6.2	7.5e-10	0.84	0.03	0.96	FALSE
6	GTEx	Esophagus Mucosa	ATP13A2	0.12	0.13	enet	8	0.13	7.3e-09	-5.9	5.3	1.3e-07	-0.81	0.02	0.98	FALSE
7	GTEx	Esophagus Mucosa	MST1L	0.13	0.07	enet	23	0.07	2.7e-05	4.4	-5.5	4.4e-08	0.71	0.05	0.94	FALSE
8	GTEx	Esophagus Mucosa	RP1-37C10.3	0.10	0.10	enet	4	0.07	3.8e-05	-5.9	5.9	3.0e-09	-0.90	0.00	0.99	FALSE
9	GTEx	Esophagus Muscularis	MFAP2	0.14	0.15	lasso	3	0.12	8.8e-08	-5.6	5.7	1.1e-08	-0.84	0.07	0.92	FALSE
10	GTEx	Heart Atrial Appendage	MST1P2	0.20	0.09	lasso	4	0.09	6.7e-05	-5.9	5.8	8.9e-09	-0.88	0.02	0.96	FALSE
11	GTEx	Liver	MST1P2	0.20	0.14	lasso	4	0.10	7.6e-04	4.9	6.1	8.5e-10	-0.92	0.01	0.96	FALSE
12	GTEx	Lung	MFAP2	0.09	0.08	enet	19	0.06	1.3e-05	-4.8	5.4	5.9e-08	-0.85	0.01	0.99	FALSE
13	GTEx	Nerve Tibial	SDHB	0.10	0.07	lasso	3	0.07	1.7e-05	-4.9	5.4	7.7e-08	-0.77	0.45	0.46	FALSE
14	GTEx	Nerve Tibial	MST1L	0.23	0.16	lasso	7	0.22	6.6e-16	-4.4	-5.9	2.8e-09	0.86	0.03	0.97	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	MST1L	0.15	0.15	lasso	4	0.13	8.2e-08	-4.4	-5.2	1.6e-07	0.80	0.04	0.96	FALSE
16	GTEx	Testis	CROCC	0.18	0.03	lasso	4	0.04	1.0e-02	4.9	-5.4	7.2e-08	0.86	0.04	0.69	FALSE
17	GTEx	Testis	MST1L	0.45	0.20	enet	34	0.25	2.5e-11	-6.4	-5.9	4.3e-09	0.74	0.02	0.98	FALSE
18	GTEx	Whole Blood	MST1L	0.08	0.02	enet	12	0.04	6.3e-05	-4.4	-5.5	4.5e-08	0.83	0.01	0.98	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	SDHB	0.04	0.04	lasso	2	0.03	5.4e-05	-4.9	5.1	3.1e-07	-0.78	0.55	0.38	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CROCC	0.09	0.04	lasso	4	0.06	1.3e-05	-4.4	-5.3	1.4e-07	0.76	0.11	0.85	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MST1P9	0.22	0.08	blup	38	0.13	7.6e-11	-6.8	-6.2	6.1e-10	0.80	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP13A2	0.05	0.00	enet	1	0.01	1.6e-02	-6.8	6.8	8.8e-12	-1.00	0.00	0.81	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	MST1P9	0.31	0.09	blup	38	0.14	2.3e-27	-4.4	-6.3	2.4e-10	0.70	0.17	0.83	FALSE
24	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MST1P9	0.11	0.11	blup	38	0.08	1.3e-04	-6.8	-6.9	6.1e-12	0.93	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	MFAP2	0.12	0.06	blup	38	0.07	4.3e-05	-5.6	7.0	2.2e-12	-0.85	0.01	0.98	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	CROCC	0.17	0.05	lasso	4	0.09	7.7e-04	-4.3	-5.1	3.0e-07	0.71	0.07	0.58	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATP13A2	0.05	0.08	enet	5	0.07	2.1e-08	-5.9	5.8	8.4e-09	-0.88	0.03	0.97	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MFAP2	0.10	0.05	enet	21	0.07	5.7e-08	-3.6	5.3	1.3e-07	-0.67	0.54	0.45	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MST1P9	0.15	0.13	enet	15	0.13	1.5e-14	-5.9	-6.8	1.5e-11	0.92	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MFAP2	0.17	0.22	enet	10	0.23	6.8e-26	-6.8	6.5	1.0e-10	-0.95	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1P9	0.15	0.13	enet	14	0.17	6.2e-19	-6.8	-7.1	1.3e-12	0.84	0.00	1.00	TRUE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ATP13A2	0.18	0.08	blup	54	0.12	3.0e-06	2.9	5.2	1.7e-07	-0.65	0.04	0.90	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP13A2	0.07	0.05	lasso	4	0.06	4.8e-07	-5.6	5.2	2.5e-07	-0.74	0.23	0.76	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	MFAP2	0.04	0.03	blup	38	0.03	6.7e-05	-5.6	5.9	3.5e-09	-0.83	0.01	0.96	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP13A2	0.06	0.04	blup	54	0.05	7.7e-07	-4.3	5.3	1.1e-07	-0.73	0.17	0.82	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MFAP2	0.04	0.02	blup	38	0.03	1.5e-04	-4.3	5.1	2.8e-07	-0.73	0.02	0.93	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MST1P9	0.04	0.02	lasso	5	0.02	1.0e-03	-6.4	-6.1	1.3e-09	0.86	0.03	0.85	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MST1P9	0.08	0.05	blup	38	0.08	4.2e-06	4.4	-6.3	2.1e-10	0.84	0.04	0.90	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ATP13A2	0.14	0.05	blup	54	0.08	2.5e-04	-3.7	6.1	9.5e-10	-0.82	0.01	0.93	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	MST1P9	0.13	0.09	lasso	6	0.11	3.3e-11	4.4	-5.7	1.4e-08	0.85	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	MST1P9	0.10	0.04	enet	11	0.05	3.4e-04	-4.4	-5.9	4.0e-09	0.59	0.03	0.56	FALSE
42	The Cancer Genome Atlas	Soft Tissue Sarcoma	SDHB	0.06	0.03	blup	99	0.02	2.1e-02	-6.4	5.9	3.1e-09	-0.84	0.02	0.65	FALSE