TWAS hub - MST1P9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.2210	0.0880	3.0e-11	0.079	0.127	0.126	NA	0.097	2.9e-07	7.6e-11	8.7e-11	NA	1.3e-08
2	TCGA	Breast Invasive Carcinoma	0.3128	0.0795	0.0e+00	0.086	0.139	0.135	NA	0.123	4.1e-17	2.2e-27	1.3e-26	NA	4.1e-24
3	TCGA	Cervical Squamous Cell Carcinoma	0.1060	0.0530	3.1e-04	0.112	0.077	0.058	NA	0.044	3.9e-06	1.3e-04	8.2e-04	NA	3.2e-03
4	TCGA	Colon Adenocarcinoma	0.0750	0.0420	5.1e-03	0.003	0.013	0.001	NA	-0.002	2.0e-01	5.4e-02	2.7e-01	NA	4.1e-01
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.1474	0.0584	4.5e-14	0.127	0.120	0.131	NA	0.087	4.5e-14	2.5e-13	1.5e-14	NA	5.4e-10
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1249	0.0511	5.3e-05	0.004	0.046	0.034	NA	0.028	9.6e-02	6.0e-06	1.0e-04	NA	3.5e-04
7	TCGA	Brain Lower Grade Glioma	0.1505	0.0526	0.0e+00	0.127	0.165	0.170	NA	0.144	2.7e-14	2.3e-18	6.2e-19	NA	5.2e-16
8	TCGA	Lung Squamous Cell Carcinoma	0.0373	0.0218	9.2e-04	0.021	0.020	0.011	NA	0.023	1.7e-03	2.1e-03	1.8e-02	NA	1.0e-03
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0800	0.0390	5.6e-05	0.046	0.080	0.061	NA	0.057	4.4e-04	4.2e-06	5.8e-05	NA	1.1e-04
10	TCGA	Prostate Adenocarcinoma	0.1256	0.0531	5.6e-10	0.088	0.087	0.088	NA	0.106	1.9e-09	2.4e-09	1.8e-09	NA	3.3e-11
11	TCGA	Soft Tissue Sarcoma	0.1030	0.0500	2.1e-04	0.035	0.055	0.055	NA	0.041	3.5e-03	3.5e-04	3.4e-04	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Lung FEV1/FVC ratio	40.8	206.8	295.8	13.7	12.7	17.2	11.3	16.4	1.6	16.3	16.4	16.4	16.6	12.3
Forced vital capacity (FVC), Best measure	26.1	95.6	134.6	-9.4	-8.9	-11.6	-8.1	-11.6	-0.1	-10.8	-10.9	-11.0	-11.1	-8.2
Forced vital capacity (FVC)	24.2	93.3	130.0	-9.4	-8.9	-11.3	-8.1	-11.4	-0.8	-10.7	-10.9	-11.0	-10.8	-8.0
Height	23.3	448.5	640.1	-21.3	-21.7	-25.3	-11.9	-23.3	0.3	-24.5	-23.2	-24.7	-22.8	-20.4
Standing height	18.9	187.5	275.6	-14.1	-13.7	-16.6	-8.2	-15.3	0.0	-16.1	-14.9	-15.7	-14.6	-12.6
Forced expiratory volume in 1-second (FEV1), predicted	16.4	34.0	50.3	-6.2	-6.3	-6.9	-2.9	-6.8	-0.1	-7.1	-6.1	-6.3	-5.7	-5.9
Comparative height size at age 10	16.3	89.7	127.7	-9.4	-9.7	-11.3	-5.6	-10.4	0.5	-10.8	-10.3	-11.1	-10.5	-9.0
Sitting height	11.7	83.0	121.0	-9.5	-9.3	-11.0	-5.3	-10.3	-0.1	-10.9	-9.9	-10.5	-9.4	-8.2
Lung FVC	11.6	58.8	96.4	-5.1	-5.4	-8.6	-8.1	-8.6	1.0	-7.8	-9.8	-9.4	-9.5	-6.3
Forced expiratory volume in 1-second (FEV1), Best measure	7.4	23.5	35.5	-4.5	-4.3	-5.6	-4.5	-6.0	0.6	-5.2	-5.4	-5.5	-5.5	-4.0
Forced expiratory volume in 1-second (FEV1)	6.7	22.7	32.8	-4.4	-4.2	-5.4	-4.6	-5.7	-0.2	-5.2	-5.5	-5.5	-5.3	-3.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.5	7.7	12.7	2.2	2.6	3.2	1.9	3.0	-0.7	2.7	3.4	3.2	3.6	2.9
Rheumatoid Arthritis	6.3	8.7	14.1	-2.7	-2.9	-3.4	-2.1	-2.8	-1.2	-3.2	-3.8	-3.6	-3.3	-2.7
Ever highly irritable/argumentative for 2 days	6.0	7.2	12.6	2.4	2.8	3.3	0.4	2.1	-1.0	3.5	3.0	3.0	2.7	3.2
Ovarian Cancer	5.8	7.7	12.3	2.4	2.5	3.2	1.0	2.2	-0.4	3.4	3.3	3.5	3.1	3.5
Average weekly fortified wine intake	5.8	6.8	13.3	-3.5	-3.3	-3.0	0.2	-2.5	0.6	-3.6	-1.4	-2.5	-2.5	-2.8
Impedance of arm (right)	5.5	25.7	38.4	-4.7	-4.8	-6.1	-3.0	-5.1	0.2	-5.9	-6.0	-6.2	-5.5	-5.1
Impedance of arm (left)	5.3	24.7	37.1	-4.5	-4.6	-6.0	-3.3	-5.0	0.6	-5.6	-6.0	-6.1	-5.5	-4.9
Impedance of whole body	5.0	25.4	41.2	-4.4	-4.3	-6.0	-4.4	-5.3	-0.5	-5.4	-6.4	-6.0	-5.8	-4.3
Heart disease (siblings)	4.9	6.0	9.1	-2.8	-2.4	-2.9	-1.2	-2.8	-1.0	-3.0	-2.5	-2.7	-2.5	-2.0
Impedance of leg (right)	4.8	23.1	40.2	-4.1	-3.9	-5.6	-4.7	-4.9	-1.3	-4.8	-6.3	-5.5	-5.8	-3.8
Hand grip strength (right)	4.6	12.6	21.9	-4.0	-3.5	-4.2	-1.4	-4.2	-0.3	-4.7	-3.5	-3.9	-3.3	-3.5
Hair/balding pattern: Pattern 3	4.4	6.6	10.1	2.8	2.9	2.9	0.6	2.4	-0.1	3.1	2.4	3.1	2.8	3.2
Impedance of leg (left)	4.1	20.0	34.0	-4.0	-3.5	-5.3	-4.7	-4.8	-1.8	-4.5	-5.8	-4.9	-5.3	-3.0
BMI	3.9	22.8	36.5	4.7	3.5	5.0	5.3	5.7	2.6	5.1	6.0	5.1	5.0	3.0
Trunk fat-free mass	3.8	22.1	32.9	-5.0	-5.2	-5.7	-1.9	-5.3	0.8	-5.7	-4.6	-5.3	-4.7	-4.7
Ever had prostate specific antigen (PSA) test	3.8	4.4	7.1	-2.1	-2.7	-2.5	-1.0	-2.4	0.5	-2.1	-2.0	-2.4	-2.3	-2.0
Frequency of depressed mood in last 2 weeks	3.7	5.1	7.3	2.2	2.5	2.7	1.7	2.6	-0.6	2.3	2.2	2.7	2.5	2.0
Trunk predicted mass	3.7	21.3	31.9	-4.9	-5.0	-5.5	-1.9	-5.2	0.8	-5.7	-4.5	-5.2	-4.7	-4.6
Hand grip strength (left)	3.6	9.4	16.0	-3.2	-3.1	-3.5	-1.0	-3.5	0.3	-4.0	-3.2	-3.5	-2.9	-3.4
Waist Hip Ratio (WHR)	3.5	15.6	25.9	-4.2	-4.1	-4.6	-3.0	-4.1	-1.5	-4.1	-3.9	-4.3	-5.1	-3.2
Leg pain on walking	3.4	4.2	5.8	2.2	2.4	2.3	0.8	1.8	0.5	2.4	2.3	2.2	2.4	2.1
Whole body fat-free mass	3.0	17.2	25.5	-4.4	-4.7	-5.0	-1.2	-4.6	1.3	-5.0	-3.8	-4.7	-4.1	-4.4
Whole body water mass	3.0	16.9	24.8	-4.4	-4.8	-4.9	-1.1	-4.6	1.3	-5.0	-3.7	-4.7	-4.0	-4.3
Basal metabolic rate	2.9	16.0	23.6	-4.1	-4.6	-4.8	-0.9	-4.3	1.7	-4.9	-3.6	-4.6	-3.9	-4.4
Average weekly red wine intake	2.8	4.1	6.9	-1.9	-1.7	-2.2	-1.6	-1.9	-0.4	-2.2	-2.3	-2.5	-2.6	-2.0
Alzheimer’s Disease (including proxy)	2.7	4.0	6.1	2.4	1.9	2.2	2.2	2.2	0.9	1.8	2.0	2.2	2.5	0.9
Peak expiratory flow (PEF)	2.6	6.1	8.9	2.9	2.7	3.0	0.5	2.6	0.3	3.0	2.2	2.7	2.7	2.6
Arm predicted mass (right)	2.6	13.6	19.2	-3.6	-4.1	-4.4	-1.4	-4.1	1.3	-4.3	-3.6	-4.2	-4.1	-3.9
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	5.3	-1.8	-2.0	-2.1	-0.3	-1.4	-0.6	-2.2	-2.1	-2.3	-1.9	-2.1
Arm predicted mass (left)	2.6	13.1	19.2	-3.9	-4.2	-4.4	-1.1	-4.0	1.0	-4.3	-3.2	-4.0	-3.7	-3.8
LDL Cholesterol	2.5	4.0	9.6	-1.4	-2.1	-2.3	1.0	-1.2	1.6	-2.6	-1.7	-2.2	-1.9	-3.1
Angina	2.5	3.3	5.2	1.7	2.1	2.0	1.8	2.3	-1.4	2.0	1.9	1.8	1.4	1.2
Body mass index (BMI)	2.5	10.5	15.9	3.6	2.5	3.6	3.5	3.8	2.7	3.3	4.0	3.2	3.2	1.7
Pain type(s) experienced in last month: Hip pain	2.5	3.1	5.8	-2.1	-2.2	-2.0	-1.6	-2.4	-0.5	-1.6	-1.4	-2.0	-1.7	-0.8
Chronic bronchitis/emphysema (mother)	2.4	2.8	4.3	1.6	1.7	2.0	0.9	1.7	0.1	2.1	1.9	1.9	1.8	1.6
Arm fat-free mass (right)	2.4	12.2	17.6	-3.5	-4.0	-4.2	-1.3	-3.9	1.2	-4.1	-3.3	-4.0	-3.7	-3.6
Arm fat-free mass (left)	2.4	12.1	17.7	-3.6	-4.0	-4.2	-1.0	-3.8	1.1	-4.2	-3.2	-3.9	-3.6	-3.7
Alzheimer’s Disease (in father)	2.3	2.5	4.6	1.4	1.2	1.8	1.7	1.9	-0.0	1.5	1.8	1.8	2.1	1.1
Vitamin and mineral supplements	2.3	3.1	8.6	-0.8	-1.4	-1.8	0.7	-1.0	2.3	-2.3	-1.5	-2.1	-1.1	-2.9
Leg fat-free mass (left)	2.3	12.2	18.2	-3.5	-4.1	-4.1	-0.3	-3.6	2.2	-4.3	-2.8	-4.0	-3.4	-4.1
Leg predicted mass (left)	2.3	12.2	18.2	-3.5	-4.1	-4.1	-0.3	-3.6	2.2	-4.3	-2.8	-4.0	-3.3	-4.1
Weight	2.2	10.6	15.8	-2.8	-3.7	-3.8	-0.2	-3.1	2.7	-3.9	-2.7	-3.9	-3.3	-4.0
Blood clot in the leg (DVT)	2.2	2.9	4.8	-2.0	-2.2	-1.9	0.1	-1.1	-0.9	-2.0	-1.7	-2.0	-1.6	-1.9
Alcohol usually taken with meals	2.1	3.4	6.0	-1.0	-1.2	-2.0	-1.9	-1.8	1.3	-2.0	-2.5	-2.4	-2.1	-1.4
Illnesses of father: High blood pressure	2.1	2.6	5.2	-2.1	-2.3	-1.7	0.8	-1.5	0.2	-2.3	-1.0	-1.4	-0.7	-2.2
Body Mass Index (BMI) (2010)	2.0	2.8	5.7	0.9	1.4	1.6	1.8	1.6	0.2	1.3	2.4	2.1	2.3	1.4
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.3	1.7	1.3	1.8	1.6	1.8	1.1	1.5	1.7	1.7	1.4	0.9
Financial situation satisfaction	2.0	2.5	5.5	1.4	1.0	1.6	2.4	1.9	0.6	1.3	2.1	1.8	1.7	0.6
Medication: Bendroflumethiazide	2.0	3.0	6.5	1.4	1.1	1.7	1.9	2.6	0.7	1.9	2.1	1.8	2.0	1.2
Bipolar Disorder (2018)	1.9	2.9	9.3	1.9	1.1	1.1	2.9	1.7	3.0	0.4	1.1	0.8	1.8	-0.6
Schizophrenia (2014)	1.9	4.1	7.1	2.6	1.6	2.3	2.1	2.1	1.2	2.0	2.0	2.0	2.7	1.3
Blood Red Count	1.9	18.2	31.4	-3.3	-3.4	-4.7	-5.0	-4.8	-0.7	-3.8	-5.6	-4.6	-5.5	-3.1
Hip circumference	1.9	8.3	13.6	-1.6	-2.6	-3.3	-0.2	-2.3	3.6	-3.2	-2.5	-3.6	-3.2	-3.7
Medication: Blood pressure	1.9	3.3	4.9	1.1	1.9	2.2	1.2	2.0	-1.3	1.8	2.2	2.2	2.0	1.8
Leg fat-free mass (right)	1.9	10.4	16.0	-3.5	-3.8	-3.8	-0.3	-3.6	1.8	-4.0	-2.5	-3.6	-3.0	-3.6
Leg predicted mass (right)	1.9	10.2	15.8	-3.5	-3.8	-3.8	-0.2	-3.5	1.8	-4.0	-2.4	-3.6	-3.0	-3.5
Risk taking	1.9	2.8	4.8	-1.3	-2.2	-1.9	-0.1	-1.3	0.7	-2.1	-1.7	-2.0	-1.7	-2.2
Bipolar Disorder or Schizophrenia	1.8	4.5	7.5	2.5	2.1	2.1	2.7	2.1	2.1	1.3	2.1	1.9	2.7	0.8
Illnesses of siblings	1.8	2.5	5.6	2.4	1.9	2.1	0.4	1.8	1.4	1.8	1.2	1.4	1.3	1.0
Medication: Seretide 50 evohaler	1.8	2.0	4.4	-0.1	-0.1	-1.5	-1.9	-1.5	0.4	-1.4	-2.1	-1.7	-1.9	-1.1
Had major operations	1.8	2.1	4.5	-1.3	-0.7	-1.6	-2.1	-2.0	-0.5	-1.6	-1.5	-1.3	-1.8	-0.3
Medication: Aspirin	1.8	2.4	4.7	1.6	1.4	1.6	1.9	2.2	0.8	1.6	1.8	1.4	1.6	0.8
Mineral and other dietary supplements	1.8	2.4	6.8	-1.2	-1.7	-1.6	1.1	-1.0	1.3	-1.8	-1.1	-1.6	-1.3	-2.6
Alzheimer’s Disease (in mother)	1.7	2.0	3.1	1.6	1.6	1.6	1.4	1.4	0.6	1.2	1.8	1.6	1.6	0.8
Trunk fat mass	1.7	7.2	12.0	-2.0	-3.0	-3.1	0.2	-2.2	2.9	-3.0	-2.1	-3.3	-2.7	-3.5
Medication: Cholesterol lowering	1.7	2.7	5.1	1.6	1.1	2.0	1.6	2.2	-0.1	2.2	2.1	1.7	1.4	1.0
Length of working week for main job	1.7	1.8	3.5	0.9	0.8	1.6	1.8	1.7	-0.2	1.3	1.9	1.5	1.4	0.9
Angina (self-reported)	1.7	2.2	3.5	1.4	1.8	1.6	1.6	1.9	-1.2	1.6	1.6	1.5	1.1	1.0
Depression (Nagel 2018)	1.6	2.3	3.5	1.8	1.8	1.7	1.0	1.6	0.0	1.6	1.7	1.9	1.4	1.4
Birth weight	1.6	3.5	8.4	-2.9	-2.5	-2.1	-0.5	-1.8	-1.4	-2.1	-1.6	-2.0	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	9.5	-1.1	-0.9	-1.8	-3.1	-2.3	-0.1	-1.4	-2.2	-2.1	-2.2	-0.9
Tinnitus: Yes, now most or all of the time	1.6	1.9	5.8	2.4	2.3	1.4	-0.2	1.5	1.7	1.5	0.1	0.4	0.5	0.2
Supplements: Calcium	1.6	1.7	3.4	1.8	1.7	1.7	-0.0	1.6	-0.5	1.5	0.6	1.2	1.1	1.3
Heel T-Score	1.5	11.9	23.8	2.2	3.3	4.0	0.2	2.6	-2.1	4.0	4.0	4.3	3.7	4.9
Qualifications: None of the above	1.5	3.3	6.4	2.5	2.3	1.9	-0.6	1.7	-0.8	2.4	0.9	1.7	1.2	2.3
Medication: Aspirin	1.5	1.9	3.7	1.6	1.2	1.4	1.5	1.9	0.9	1.5	1.5	1.1	1.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.5	1.5	1.3	1.6	0.6	1.5	-1.1	1.6	1.4	1.6	1.0	1.3
Number of incorrect matches in round	1.4	2.4	5.0	-0.9	-1.3	-1.8	0.2	-1.5	0.1	-1.9	-2.2	-2.1	-0.6	-2.1
Exposure to tobacco smoke at home	1.4	1.5	6.0	0.5	-1.4	-0.5	1.8	0.8	1.5	0.1	-0.6	-0.9	-1.2	-2.4
Alcohol intake frequency.	1.4	3.2	4.9	1.6	1.8	1.7	1.0	2.0	-0.1	2.1	1.9	2.0	2.2	2.0
Commuting to job workplace: Cycle	1.4	1.6	7.2	0.6	0.2	-0.8	-0.5	0.2	2.7	-0.4	-1.6	-1.6	-1.5	-1.4
Age when periods started (menarche)	1.3	3.1	5.5	-1.7	-2.3	-2.0	-0.5	-1.3	-0.5	-1.7	-2.2	-2.0	-2.1	-1.8
Qualifications: CSEs or equivalent	1.3	1.7	3.3	-1.0	-1.2	-1.2	-1.5	-1.7	-0.0	-1.1	-1.5	-1.3	-1.8	-1.0
Waist circumference	1.3	4.9	7.8	-1.3	-2.2	-2.6	-0.2	-1.8	2.5	-2.3	-1.7	-2.7	-2.8	-2.8
Loneliness, isolation	1.3	1.9	3.1	1.4	1.2	1.8	0.5	1.1	-0.9	1.6	1.5	1.2	1.8	1.4
Qualifications: nursing, teaching	1.3	2.0	4.1	-0.1	-0.6	-1.3	-0.4	-0.7	2.0	-1.5	-1.6	-1.9	-1.6	-2.0
Schizophrenia (2018)	1.2	2.4	4.1	1.8	1.7	1.8	1.1	1.3	0.3	1.4	1.8	1.8	2.0	1.3
Ulcerative Colitis	1.2	1.8	3.8	-1.1	-0.8	-1.5	-0.7	-1.3	-0.9	-1.6	-1.9	-1.7	-1.5	-1.0
Severe depression (siblings)	1.2	1.3	3.9	-0.5	-0.0	0.8	-0.4	0.0	-2.0	0.9	1.6	1.3	1.1	1.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	0.2	0.5	0.9	1.5	0.8	0.1	1.0	1.7	1.5	1.7	1.2
Multivitamins +/- minerals	1.2	1.5	3.2	1.0	1.3	1.4	0.0	1.1	-1.0	1.7	1.0	1.5	0.7	1.8
Worrier / anxious feelings	1.2	2.2	4.0	2.0	1.8	1.9	1.0	1.9	0.5	1.4	1.2	1.4	1.6	0.7
Age at first live birth	1.2	2.1	5.2	-1.2	-1.0	-1.7	-1.6	-1.3	-0.3	-1.3	-1.8	-1.6	-2.3	-1.2
Pulse rate, automated reading	1.2	3.8	6.0	2.1	2.4	2.3	0.2	1.1	-0.4	2.3	2.0	2.2	2.2	2.3
Chest pain or discomfort	1.2	1.7	5.0	1.0	0.3	1.2	2.2	1.8	-0.3	1.1	1.4	1.4	1.5	0.4
Eye problems/disorders: Cataract	1.2	1.4	6.2	0.4	1.0	-0.5	-2.5	-0.9	0.2	-0.3	-1.2	-0.9	-2.2	0.1
Fractured/broken bones in last 5 years	1.2	1.5	5.9	1.3	0.0	0.7	2.4	1.2	1.7	0.1	0.6	0.4	1.6	-0.9
Ulcerative Colitis (UC)	1.1	2.1	5.7	-0.1	-0.2	-1.1	-1.5	-1.2	0.0	-1.6	-2.4	-1.9	-1.9	-1.5
HbA1C	1.1	1.2	2.2	1.3	1.5	1.3	0.6	1.4	0.2	1.3	0.9	1.0	1.0	0.7
Neuroticism (2016)	1.1	1.6	3.2	1.4	0.9	1.7	1.7	1.8	-0.4	1.0	1.1	1.1	1.5	0.3
Ever had hysterectomy (womb removed)	1.1	1.2	3.1	1.3	1.7	1.2	-0.3	0.7	0.1	0.9	0.6	1.1	1.1	1.8
Diabetes (mother)	1.1	1.4	2.5	-1.5	-0.6	-1.6	-0.9	-1.5	-0.8	-1.4	-1.0	-1.1	-1.1	-0.8
Pulse wave reflection index	1.1	1.3	5.5	-0.3	0.6	0.7	-2.1	-0.4	-2.4	0.9	0.0	0.5	0.0	1.6
Medication for pain relief, constipation, heartburn	1.1	1.8	3.1	-1.2	-1.7	-1.4	-0.3	-1.4	0.2	-1.6	-1.8	-1.4	-1.2	-1.6
Migraine (self-reported)	1.1	1.4	4.2	-0.2	-0.8	-1.0	0.2	-0.7	1.9	-1.2	-1.2	-1.4	-0.8	-2.0
Serious illness, injury or assault to yourself	1.0	1.2	2.4	-0.9	-0.5	-1.5	-0.5	-1.3	1.0	-1.6	-0.8	-1.2	-1.1	-1.0
Financial difficulties in last 2 years	1.0	1.3	3.0	1.6	0.7	1.1	1.2	1.7	1.6	1.1	0.9	0.6	0.7	-0.0
Heart attack	1.0	1.2	2.1	0.7	1.4	1.2	-0.1	0.9	-1.3	1.4	1.2	1.3	0.5	1.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.6	1.6	1.1	1.4	1.5	1.6	0.9	0.6	1.1	0.8	1.0	-0.3
Medication: Ramipril	1.0	1.2	1.9	0.6	0.9	1.3	0.2	1.0	-1.3	1.3	1.4	1.2	1.2	1.3
Tense / ‘highly strung’	1.0	1.7	3.6	1.9	1.8	1.6	-0.2	1.6	-0.0	1.4	1.0	1.2	0.9	1.2
Medication: Gliclazide	1.0	1.1	5.1	1.0	0.6	0.4	1.8	1.1	2.2	0.3	0.7	0.4	0.6	-0.1
Smoking status: Current	1.0	1.6	4.6	-2.1	-1.7	-1.5	0.5	-1.5	0.0	-1.6	-0.3	-0.9	-0.9	-0.9
Pack years of smoking	1.0	1.5	2.8	1.7	1.0	1.0	1.4	1.2	1.2	1.4	1.4	1.2	0.9	0.5
Age at First Birth	0.9	1.3	3.4	0.1	0.8	1.2	0.6	0.5	-0.9	0.9	1.9	1.4	1.6	1.4
Fasting Glucose	0.9	1.1	2.6	0.7	0.6	1.0	0.4	1.1	-0.9	1.6	1.4	1.4	0.8	1.1
Number of treatments/medications taken	0.9	1.7	3.2	1.6	1.8	1.5	-0.4	1.6	-0.0	1.5	1.2	1.2	0.6	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.3	0.5	1.1	1.6	0.8	0.9	-0.4	1.4	2.1	2.3	1.3	1.9
Fluid intelligence score	0.9	1.8	5.4	-0.7	-1.5	-1.2	1.4	-0.7	2.3	-1.5	-0.7	-0.8	-0.5	-2.0
Prospective memory result	0.9	1.1	2.0	0.6	1.4	1.3	0.3	0.9	-1.0	1.2	0.9	1.0	1.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.9	-1.1	-1.3	-1.5	-1.4	-1.7	0.3	-1.1	-1.5	-1.2	-1.4	-0.7
Number of full brothers	0.9	1.1	2.5	0.3	0.2	0.9	1.3	1.3	-0.9	1.0	1.1	1.1	1.6	1.1
Shortness of breath walking on level ground	0.9	1.0	4.2	1.8	0.7	0.4	1.1	1.1	2.0	0.5	0.2	-0.1	0.2	-0.7
Age at last live birth	0.9	1.2	3.9	-1.2	-0.5	-1.3	-1.4	-0.9	-0.7	-0.9	-1.2	-0.9	-2.0	-0.3
Supplements: Vitamin C	0.9	1.1	2.9	0.6	0.8	1.1	-0.8	0.5	-0.8	1.2	0.9	1.1	1.3	1.7
Wears glasses or contact lenses	0.9	1.0	2.1	0.7	1.3	1.3	-0.2	0.6	-0.6	1.0	1.3	1.0	0.7	1.5
Unable to work because of sickness or disability	0.9	1.2	3.1	1.8	1.1	1.2	0.6	1.6	0.3	1.4	1.0	0.9	0.9	0.4
Schizophrenia vs Biploar Disorder	0.8	1.1	6.0	-0.5	-0.3	-0.2	-1.7	-0.9	-2.5	0.4	-0.5	-0.1	-0.2	1.0
Reaction Time	0.8	1.5	2.8	1.7	1.2	1.5	0.7	1.6	-0.0	1.4	1.0	1.2	1.4	0.6
Primary Biliary Cirrhosis	0.8	1.1	2.7	1.6	1.6	1.1	-0.5	1.0	0.9	1.4	0.5	0.8	0.0	1.0
Medication for hormone replacement therapy	0.8	0.9	1.6	-1.0	-0.4	-0.7	-0.7	-0.6	-1.2	-1.2	-1.1	-1.1	-1.1	-0.8
Trunk fat percentage	0.8	3.3	9.8	-0.7	-1.8	-1.8	0.8	-0.8	3.1	-1.7	-1.0	-2.2	-1.6	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.0	1.1	1.4	1.3	-0.1	1.0	1.0	1.6	1.5	2.0	1.1	2.0
Alcohol intake versus 10 years previously	0.8	1.1	3.4	-0.9	0.1	0.2	-0.0	-0.5	-1.8	0.4	1.0	1.2	1.5	1.7
Medication: Amlodipine	0.8	1.1	2.2	-1.2	-1.2	-1.2	-0.1	-0.7	-1.2	-0.8	-1.5	-1.2	-1.1	-1.0
Eye problems/disorders: None of the above	0.8	0.9	2.8	-0.6	-0.7	0.6	1.6	0.7	-1.3	0.3	0.9	0.5	1.7	-0.0
Whole body fat mass	0.8	3.5	6.9	-1.2	-2.2	-2.0	0.6	-1.2	2.6	-1.9	-1.1	-2.2	-1.8	-2.5
Commuting to job workplace: Car/motor vehicle	0.8	1.0	3.5	-0.3	-0.2	-1.0	-1.9	-1.4	-0.1	-0.7	-1.2	-1.0	-0.8	-0.4
Arm fat percentage (left)	0.8	3.0	11.7	1.8	0.6	1.3	2.4	1.9	3.4	1.1	1.9	0.7	1.1	-0.4
Guilty feelings	0.8	1.2	4.2	1.1	0.1	1.2	2.1	1.6	0.4	1.0	1.1	0.7	0.9	-0.2
Ever depressed for a whole week	0.8	1.0	2.1	1.2	1.4	1.1	-0.0	0.2	0.9	1.5	1.2	1.1	0.6	1.0
Cholesterol lowering medication	0.8	1.2	2.8	-0.5	-0.3	-1.3	-0.4	-0.9	0.3	-1.4	-1.7	-1.6	-1.1	-1.4
Average weekly spirits intake	0.7	0.9	2.1	-1.3	-0.7	-0.9	-1.3	-1.4	-1.1	-0.4	-0.2	-0.3	-1.2	0.3
Medication: Co-codamol	0.7	0.9	3.8	-0.2	0.2	0.3	-0.9	-0.3	-2.0	0.8	0.5	0.7	0.6	1.6
Medication: Metformin	0.7	0.9	3.2	0.9	0.7	0.6	1.8	1.1	1.4	0.6	0.8	0.6	0.8	-0.2
Pack years adult smoking proportion	0.7	1.0	2.0	1.4	0.8	0.7	1.2	1.0	1.0	1.2	1.1	1.1	0.6	0.3
Current tobacco smoking	0.7	1.1	3.6	-1.9	-1.5	-1.1	0.2	-1.3	-0.3	-1.3	-0.1	-0.7	-0.8	-0.7
Maternal smoking around birth	0.7	1.1	3.3	0.4	-1.1	-0.2	1.5	0.0	1.6	-0.7	-0.5	-0.9	-0.6	-1.8
Supplements: Glucosamine	0.7	0.9	2.3	1.1	1.5	1.1	-0.1	0.9	0.3	1.1	0.4	0.9	0.6	1.2
Past tobacco smoking	0.7	1.2	2.9	1.2	1.7	1.3	-0.8	0.7	0.5	1.1	0.7	1.0	1.1	1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.7	1.6	1.2	0.8	0.4	0.3	1.6	1.1	0.6	0.5	0.1	-0.0
Arm fat percentage (right)	0.7	2.7	10.5	1.5	0.4	1.1	2.5	1.7	3.2	0.8	1.8	0.6	1.1	-0.5
Lung cancer (father)	0.7	0.8	2.9	1.0	-0.2	-0.0	1.7	1.0	1.7	0.3	0.1	-0.1	0.3	-1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.7	1.6	1.5	0.6	-0.0	0.8	1.6	0.6	0.1	0.5	0.5	0.5
Overall health rating	0.7	1.5	3.0	1.7	1.1	1.1	1.7	1.6	1.0	1.0	1.3	0.9	0.9	0.0
Ever had bowel cancer screening	0.7	0.9	2.3	0.6	-0.5	-0.7	0.4	0.1	1.4	-0.4	-1.5	-1.0	-0.8	-1.4
Ever taken oral contraceptive pill	0.7	0.8	1.5	0.5	0.9	1.2	-0.6	0.5	-1.1	1.0	0.7	1.1	0.7	1.2
Eye problems/disorders: Glaucoma	0.7	0.9	1.9	0.9	0.7	0.6	1.4	1.1	0.8	0.8	1.2	1.0	0.8	0.4
Medication: Paracetamol	0.7	1.1	3.9	-0.1	0.7	-0.6	-2.0	-0.8	-0.8	-0.6	-1.2	-1.0	-1.7	-0.2
Alcohol drinker status: Never	0.7	0.9	2.1	0.9	0.7	0.7	1.4	1.4	0.8	0.7	1.1	0.8	0.9	0.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	0.4	1.1	0.9	-0.1	0.7	-1.4	1.2	1.0	1.0	0.4	1.2
Breast Cancer	0.6	1.5	2.5	1.1	1.0	1.4	0.7	1.3	-0.1	1.5	1.4	1.6	1.3	1.0
Chronotype (morning person)	0.6	1.3	6.8	-1.2	0.6	-0.2	-1.9	-0.8	-2.6	-0.4	-0.6	-0.1	-0.1	1.2
Relative age of first facial hair	0.6	1.3	6.7	-0.7	-0.0	0.6	1.4	0.5	-2.6	-0.0	1.2	0.9	1.4	0.4
Medication: Lansoprazole	0.6	0.7	1.5	0.7	1.2	1.1	-0.2	0.8	0.1	0.9	1.0	0.7	0.8	1.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.4	0.5	-0.2	-0.5	-0.1	-0.5	1.8	-0.3	-1.1	-1.0	-0.6	-1.2
Comparative body size at age 10	0.6	1.6	4.9	1.3	0.5	1.0	2.2	1.3	1.8	0.7	1.2	0.9	1.6	0.0
Wheeze or whistling in the chest in last year	0.6	1.1	2.9	1.2	0.9	0.4	1.4	0.9	1.7	0.5	1.1	0.7	1.2	0.3
Health satisfaction	0.6	0.8	4.7	1.4	0.9	0.3	0.3	0.3	2.2	0.3	0.0	-0.1	-0.5	-0.7
Emphysema/chronic bronchitis	0.6	0.6	1.5	0.6	0.1	-0.6	-0.5	-0.3	0.8	-0.7	-1.1	-1.0	-1.2	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.6	-1.2	-1.2	-0.5	-0.2	-1.6	-0.8	-0.9	0.1	-0.6	-0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.5	-1.4	-1.6	-0.8	-0.1	-1.0	-1.3	-0.8	-1.1	-0.8	-0.3	-0.6
Average weekly champagne plus white wine intake	0.6	0.8	2.9	0.1	-0.5	-0.6	-1.0	-0.6	1.7	-0.5	-0.9	-0.9	-1.4	-0.7
High cholesterol (Self-reported)	0.6	1.0	3.5	-0.5	-1.1	-0.8	0.8	0.1	0.1	-1.1	-1.0	-1.3	-0.9	-1.9
Ever smoked	0.6	1.0	2.5	-1.0	-1.3	-1.0	1.2	-0.4	-0.4	-0.9	-0.3	-0.9	-1.0	-1.6
Age started oral contraceptive pill	0.6	0.7	1.5	-0.9	-0.1	-0.8	-0.9	-0.8	-0.6	-1.2	-1.1	-1.2	-0.6	-0.4
Depressed Affect (Nagel 2018)	0.5	1.1	1.7	1.0	1.2	1.2	0.1	0.6	-0.8	1.2	1.3	1.3	0.9	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.2	0.3	-0.7	-0.4	1.8	0.2	2.0	-0.8	-0.3	-0.4	-0.4	-2.0
Coronary Artery Disease (CAD)	0.5	0.6	1.2	1.0	0.7	0.9	0.7	1.1	0.6	0.8	0.6	0.8	0.9	0.6
Mean Putamen Volume	0.5	0.5	1.5	1.2	0.5	-0.3	-0.6	-0.2	1.2	-0.2	-1.0	-0.7	-0.5	-0.6
Smoking Status	0.5	1.2	3.2	-1.6	-1.8	-1.2	1.3	-0.9	-0.3	-1.3	-0.2	-0.6	-0.4	-1.2
Diabetes (father)	0.5	0.6	2.0	-0.5	-0.5	-1.1	-1.0	-1.4	0.7	-0.9	-0.5	-0.6	-0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	-0.9	-0.8	-0.5	-1.1	-0.4	-1.3	-0.2	-0.8	-0.7	-0.5	0.4
High blood pressure	0.5	1.3	4.8	1.3	0.5	1.1	2.2	2.1	0.4	0.8	0.6	0.5	0.8	-0.6
Medication: Atenolol	0.5	0.6	2.3	-1.0	-0.9	0.1	1.5	0.7	-0.9	-0.3	0.6	0.1	0.4	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.2	-0.7	-0.5	0.8	-0.2	1.4	-0.5	-0.0	-0.7	-0.7	-1.3
Pain all over the body in last month	0.5	0.5	1.5	-1.2	-0.9	-0.9	0.2	-0.5	-0.1	-0.9	-0.3	-0.6	-0.5	-0.6
Falls in the last year	0.5	0.6	2.3	0.2	0.1	0.4	1.5	0.5	1.1	0.1	1.4	0.6	0.8	0.3
Asthma	0.5	0.9	4.5	0.1	-0.2	-0.9	0.9	-0.6	2.1	-1.2	-0.5	-0.6	-0.4	-1.2
Depression (self-reported)	0.5	0.5	3.1	-1.1	-0.2	-0.4	-0.6	-0.7	-1.8	-0.5	-0.0	-0.2	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.2	-1.1	-1.1	-1.1	0.1	-0.7	0.8	-1.0	-0.7	-0.9	-0.4	-1.1
Gout (self-reported)	0.5	0.7	4.5	0.5	-0.2	-0.4	0.6	-0.2	2.1	-0.3	-0.5	-0.6	-0.6	-0.9
Leg fat percentage (right)	0.5	1.8	5.8	1.8	0.5	1.1	1.6	1.8	2.4	1.2	1.3	0.6	0.4	-0.3
Worry too long after embarrassment	0.5	0.8	4.6	0.4	-0.3	0.3	2.1	0.9	0.7	0.2	0.8	0.6	1.3	-0.5
Number of children fathered	0.5	0.6	2.3	-0.8	0.5	-0.4	-1.5	-1.1	-0.2	-0.3	0.0	-0.1	-0.9	0.9
Medication: Omeprazole	0.5	0.6	2.4	0.9	0.3	0.1	-1.0	0.2	1.6	0.1	-0.7	-0.7	-1.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	0.6	-0.1	0.8	1.2	0.9	-0.2	0.9	0.9	1.1	0.8	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	-1.1	-1.0	-0.8	-0.4	-0.8	0.2	-0.9	-0.5	-0.6	-0.7	-0.4
Osteoporosis (self-reported)	0.5	0.6	1.6	-0.7	-0.6	-0.9	-0.5	-0.4	-0.3	-0.5	-0.9	-0.9	-1.3	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	1.0	1.0	0.5	-1.2	0.6	-0.5	1.1	-0.7	0.2	-0.1	0.9
Mother’s age at death	0.5	0.6	2.7	0.9	1.6	0.4	-1.2	0.2	0.2	0.4	0.1	0.3	0.4	1.1
Medication: Atorvastatin	0.5	0.6	3.5	0.3	-0.5	0.4	1.9	0.8	0.3	0.1	0.4	-0.1	0.1	-1.4
Leg fat percentage (left)	0.5	2.0	4.9	1.8	0.8	1.3	1.6	1.8	2.2	1.3	1.5	0.9	0.8	0.1
Irritability	0.5	0.8	1.8	1.2	1.0	1.1	0.2	1.0	0.1	1.3	0.9	1.0	0.4	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.2	4.4	-1.5	-0.9	-1.2	-1.7	-2.1	0.1	-0.8	-0.6	-0.5	-0.6	0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	0.4	-0.4	-0.3	0.1	0.3	1.6	-0.3	-0.5	-0.9	-1.1	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.1	-0.2	-1.4	-0.3	2.0	0.4	1.9	-0.5	0.1	-0.3	-0.0	-1.7
Worry (Nagel 2018)	0.4	0.8	2.9	1.5	1.7	0.9	-1.1	0.6	0.1	0.5	-0.0	0.4	0.3	0.7
Triglycerides	0.4	0.7	3.1	-1.0	-1.2	-0.4	1.8	-0.0	-0.2	-0.8	0.7	-0.1	0.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	3.3	0.4	-0.7	0.2	1.8	1.1	0.4	0.1	0.5	0.1	0.3	-0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	0.4	0.7	0.4	-0.0	0.5	0.5	0.8	0.6	0.6	0.5	1.1
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.4	-0.0	0.8	1.2	1.0	0.3	1.1	1.0	0.8	0.8	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.8	1.0	0.4	0.6	0.7	0.8	1.3	0.0	0.0	0.1	0.0	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	-0.7	-0.3	-0.6	-0.7	-0.6	-1.0	-0.8	-0.7	-0.6	-1.0	-0.6
Allergy	0.4	0.9	3.9	-0.2	0.4	0.9	-0.5	0.5	-2.0	1.2	0.7	1.0	0.7	1.2
Diabetes (self-reported)	0.4	0.6	2.8	0.2	-0.2	-0.2	1.7	0.6	1.6	-0.1	0.1	-0.2	0.0	-1.0
Neuroticism score	0.4	0.9	1.5	1.2	1.0	1.2	0.9	1.1	-0.5	0.9	0.9	1.0	0.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.4	0.9	0.1	0.6	1.6	1.1	0.3	0.3	0.6	0.1	-0.0	-1.1
Noisy workplace	0.4	0.5	0.7	0.8	0.6	0.7	0.8	0.8	0.4	0.8	0.8	0.8	0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	1.0	1.0	0.5	-0.0	0.4	1.3	0.6	0.7	0.6	0.3	0.5
Pulse wave Arterial Stiffness index	0.4	0.4	1.3	-0.4	0.1	-0.4	-1.2	-0.9	-0.3	-0.8	-0.5	-0.6	-0.9	-0.1
Arm fat mass (right)	0.4	1.6	8.0	-0.2	-1.3	-0.6	1.9	0.0	2.8	-0.8	0.5	-0.8	-0.3	-1.7
Birth weight of first child	0.4	0.7	2.5	-1.6	-0.6	-0.8	0.4	-0.8	-0.7	-1.5	0.4	-0.5	0.2	-0.2
Headache pain in last month	0.4	0.7	2.2	1.3	1.1	0.8	-0.1	0.7	1.5	0.7	0.5	0.3	0.3	0.2
Body fat percentage	0.4	1.4	9.2	0.4	-0.8	-0.5	1.3	0.4	3.0	-0.4	0.2	-0.9	-0.5	-1.5
Neck or shoulder pain in last month	0.4	0.6	2.1	1.5	0.9	0.7	0.3	0.8	0.9	0.9	0.6	0.8	0.3	0.2
Medication: Ibuprofen	0.4	0.5	2.2	0.9	1.1	0.4	-0.4	0.3	1.5	0.4	0.5	0.5	0.0	0.7
Mean time to correctly identify matches	0.4	0.8	2.2	1.5	1.1	1.0	0.0	1.2	-0.2	1.0	0.4	0.7	0.8	0.5
Number of full sisters	0.4	0.4	1.3	-1.1	-0.8	-0.3	0.7	0.0	-1.1	0.2	0.7	0.6	0.3	0.3
Illnesses of father: Heart disease	0.4	0.6	1.6	-1.3	-1.3	-0.2	0.6	-0.5	-0.9	0.1	1.0	0.3	0.7	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-0.9	-0.7	-1.1	0.3	-0.4	-0.6	-0.8	-0.9	-0.6	-0.5	-0.8
Diabetes diagnosed by doctor	0.4	0.6	2.8	0.4	-0.0	0.1	1.7	0.7	1.4	0.1	0.3	-0.2	-0.1	-1.0
Medication for cholesterol	0.4	0.7	1.8	-0.5	0.0	0.5	0.2	-0.1	-1.1	0.5	1.3	1.2	0.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	0.7	1.1	0.4	-0.7	0.1	-1.0	0.8	0.5	0.6	-0.0	0.6
Asthma (self-reported)	0.4	0.7	3.0	0.0	-0.1	-0.8	0.9	-0.5	1.7	-1.1	-0.5	-0.5	-0.4	-1.1
Arm fat mass (left)	0.4	1.4	8.8	0.2	-0.9	-0.3	1.8	0.3	3.0	-0.4	0.6	-0.6	-0.2	-1.5
Miserableness	0.4	0.8	1.7	0.7	0.6	1.1	0.2	0.4	-1.1	1.1	1.0	1.3	0.6	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.2	-0.4	0.0	0.2	-1.1	-0.4	-1.5	0.2	-0.0	0.3	0.4	1.0
Neuroticism (Nagel 2018)	0.3	0.7	1.8	1.3	1.3	1.0	-0.0	0.7	0.0	0.9	0.8	0.8	0.6	0.8
Crohns Disease (2017)	0.3	0.8	1.6	1.1	0.8	0.9	1.3	0.9	1.2	0.6	0.6	0.6	0.8	-0.1
Crohns Disease (2012)	0.3	0.5	1.2	-0.3	-1.0	-0.3	0.9	-0.3	1.1	-0.3	-0.2	-0.6	-0.2	-1.1
Lupus	0.3	0.4	2.2	-0.3	-0.6	0.1	1.5	0.1	0.2	0.1	0.9	0.0	0.8	-0.5
Blood Eosinophil Count	0.3	2.5	5.4	-1.7	-2.1	-1.2	1.9	-1.0	1.5	-2.3	0.3	-1.1	-0.4	-2.2
Hypothyroidism (self reported)	0.3	0.7	2.2	1.5	1.4	1.2	0.2	1.1	0.6	0.7	0.3	0.0	0.2	0.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.1	-0.1	-0.7	-0.1	1.5	0.4	1.3	-0.1	0.2	-0.3	-0.3	-1.3
Neuroticism	0.3	0.8	1.5	1.1	1.2	1.1	-0.3	0.7	-0.9	1.0	0.8	1.0	0.4	0.9
Fed-up feelings	0.3	0.6	1.2	0.9	1.0	1.1	0.1	0.8	-1.1	1.1	0.5	0.8	-0.0	0.5
Relative age voice broke	0.3	0.5	1.1	-0.8	-0.4	0.3	0.8	0.3	-1.0	0.2	1.1	0.6	1.0	0.5
Nervous feelings	0.3	0.5	2.1	0.6	0.0	0.3	1.4	1.2	-0.1	0.0	-0.1	0.1	0.4	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.5	0.3	0.8	0.8	0.7	-1.1	0.6	0.7	0.7	0.6	0.2
Had other major operations	0.3	0.4	1.2	-0.5	-0.1	0.5	-0.3	0.3	-0.6	0.3	1.0	0.5	0.9	1.1
Mouth/teeth dental problems	0.3	0.4	1.4	0.8	1.2	0.4	-0.6	0.5	1.0	0.1	0.4	0.3	0.3	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.0	-0.1	-0.3	-0.8	0.1	-0.4	1.7	-0.9	-0.8	-0.9	-0.3	-1.4
Mouth/teeth dental problems: Dentures	0.3	0.5	2.9	-0.8	-1.0	-0.1	0.5	-0.0	-1.7	0.2	0.2	-0.0	-0.1	-0.2
Loud music exposure frequency	0.3	0.3	1.2	0.2	0.0	0.5	1.1	0.3	0.4	0.3	0.7	0.6	0.9	-0.0
Medication: Paracetamol	0.3	0.6	2.1	-0.3	0.6	-0.2	-1.5	-0.6	-1.4	-0.2	-0.5	-0.5	-0.8	0.3
Glaucoma (self-reported)	0.3	0.3	0.7	0.5	0.7	0.5	0.8	0.7	-0.1	0.5	0.7	0.5	0.6	0.3
Exposure to tobacco smoke outside home	0.3	0.4	1.2	-0.4	-1.1	-0.6	0.3	-0.1	0.5	-0.4	-0.7	-0.8	-0.7	-1.1
Pulse wave peak to peak time	0.3	0.3	1.1	-0.6	-1.1	-0.7	0.7	-0.0	0.2	-0.3	-0.5	-0.4	-0.1	-0.8
Leg fat mass (right)	0.3	1.1	6.1	0.0	-0.9	-0.5	1.2	0.1	2.5	-0.7	0.2	-0.9	-0.7	-1.5
Suffer from ‘nerves’	0.3	0.4	1.7	0.1	0.4	-0.0	-1.3	-0.5	-1.3	-0.1	-0.8	-0.3	-0.4	0.5
Knee pain experienced in last month	0.3	0.5	1.9	0.2	0.1	-0.1	-1.3	-0.4	-1.0	0.9	-0.3	0.3	0.5	1.4
Hypertension (Self-reported)	0.3	0.7	2.6	1.0	0.5	0.8	1.6	1.6	0.0	0.5	0.4	0.2	0.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.5	0.8	0.3	0.4	0.2	0.3	1.6	0.2	0.1	-0.1	-0.2	-0.6
Smoking status: Previous	0.3	0.4	0.8	-0.5	-0.9	-0.7	-0.1	-0.4	-0.6	-0.4	-0.7	-0.8	-0.8	-0.8
Long-standing illness, disability or infirmity	0.3	0.5	1.9	0.1	-0.4	-0.3	0.8	-0.1	1.1	-0.8	-0.1	-0.8	-0.2	-1.4
Osteoarthritis (self-reported)	0.3	0.4	2.5	0.7	0.3	-0.6	-0.4	-0.2	0.2	0.0	-1.6	-0.7	-0.4	-0.6
Number of self-reported non-cancer illnesses	0.3	0.5	3.1	0.2	-0.4	0.1	1.8	0.9	0.2	-0.3	0.1	-0.2	-0.0	-1.2
Hearing aid user	0.3	0.4	2.2	0.8	0.4	0.2	0.6	0.3	1.5	-0.2	0.4	-0.2	0.6	-0.4
Commuting to job workplace: Public transport	0.3	0.4	2.2	-0.8	-0.5	-0.1	1.5	0.3	-0.2	-0.5	0.1	-0.2	-0.1	-0.6
Medication: Blood pressure	0.3	0.5	1.2	0.4	-0.5	-0.6	-0.0	0.1	1.1	-0.2	-1.1	-1.1	-0.6	-0.8
Medication: Lisinopril	0.3	0.4	2.5	0.5	0.0	-0.3	0.4	0.3	1.6	-0.4	-0.5	-0.5	-0.4	-0.8
Alcohol drinker status: Previous	0.3	0.3	1.5	-0.5	-1.2	-0.6	0.4	0.3	-0.1	-0.0	-0.4	-0.6	-0.4	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	0.7	0.5	-0.1	-0.4	-0.2	0.7	-0.6	-1.1	-0.9	-0.7	-0.8
Prostate Cancer	0.2	0.3	1.6	-0.7	-0.5	-0.6	-0.6	-0.5	-1.3	-0.1	-0.5	-0.2	-0.4	0.0
HDL Cholesterol	0.2	0.4	1.7	0.0	0.6	0.0	-1.3	-0.2	-0.8	0.5	-0.5	-0.1	-0.4	0.8
Allergy or Eczema	0.2	0.6	4.2	1.2	0.5	0.2	0.7	0.5	2.1	-0.1	-0.1	-0.0	0.4	-0.3
Cardiovascular Disease	0.2	0.7	2.4	0.8	-0.2	-0.2	1.6	1.1	0.6	-0.4	-0.5	-0.7	-0.3	-1.6
Respiratory disease	0.2	0.5	3.5	0.4	0.3	-0.6	0.2	-0.5	1.9	-0.8	-0.2	-0.2	-0.4	-0.5
Sensitivity / hurt feelings	0.2	0.3	0.8	0.6	0.9	0.6	0.7	0.5	-0.4	0.3	0.5	0.5	0.6	0.1
Hearing difficulty/problems: Yes	0.2	0.3	1.4	0.5	-0.1	-0.6	0.2	-0.0	1.2	-0.2	-0.7	-0.6	0.3	-0.4
Systolic blood pressure, automated reading	0.2	0.7	2.5	0.8	0.8	0.6	1.6	1.0	0.3	0.0	0.6	0.6	1.1	-0.1
Supplements: Zinc	0.2	0.2	0.9	0.4	-0.4	0.2	-0.7	0.3	-0.1	0.5	-0.3	0.0	-0.9	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	3.0	1.3	0.4	0.2	0.7	0.6	1.7	0.1	-0.1	-0.1	0.2	-0.4
Stomach or abdominal pain in last month	0.2	0.3	1.5	-0.3	0.0	0.2	1.2	0.2	-0.2	-0.1	0.8	0.5	0.6	0.1
High blood pressure (mother)	0.2	0.3	0.5	-0.2	-0.6	-0.7	0.5	-0.5	0.6	-0.4	-0.6	-0.0	0.4	-0.6
Hearing difficulty/problems with background noise	0.2	0.2	0.7	-0.1	-0.5	-0.6	-0.4	-0.5	-0.5	-0.1	-0.8	-0.6	-0.2	-0.5
Number of live births	0.2	0.3	0.9	0.4	0.5	0.7	-0.0	0.5	0.2	0.6	0.8	1.0	0.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.8	-0.8	-0.4	-0.4	-0.6	-0.5	-0.2	-0.5	-0.0	-0.3	0.2
Breastfed as a baby	0.2	0.3	1.4	-0.5	0.2	-0.2	-0.6	-0.0	-1.2	-0.2	0.3	0.1	-0.1	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	-0.6	0.1	-0.1	-1.4	-0.9	-1.3	0.1	-0.1	0.1	-0.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	1.0	1.1	0.9	-0.1	0.6	0.1	0.4	0.2	-0.1	-0.1	0.0
High blood pressure (siblings)	0.2	0.3	1.7	-0.8	-0.8	-0.1	0.5	0.1	-1.3	0.1	0.6	0.3	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.4	-0.8	-0.4	-0.1	-0.2	0.5	-0.3	-0.4	-0.7	-0.7	-0.8
Qualifications: College or University degree	0.2	0.8	1.6	-0.9	-0.9	-0.8	1.1	-0.5	1.0	-1.3	-0.2	-0.8	0.1	-1.3
Heart disease (mother)	0.2	0.2	1.0	-1.0	-0.8	-0.5	-0.0	-0.6	-0.4	-0.2	-0.0	-0.3	-0.2	-0.1
Family relationship satisfaction	0.2	0.2	0.7	-0.4	-0.3	-0.1	0.9	-0.4	-0.8	-0.2	0.2	0.2	0.7	-0.2
Friendships satisfaction	0.2	0.3	1.1	0.9	0.5	0.4	-0.2	0.2	1.1	0.5	0.4	0.2	-0.5	-0.0
Commuting to job workplace: Walk	0.2	0.2	1.1	-0.2	-0.1	0.2	1.1	0.3	-0.7	-0.1	0.2	0.5	0.5	-0.1
Breast cancer (self-reported)	0.2	0.3	0.8	-0.1	-0.4	-0.3	0.3	-0.1	0.7	-0.7	-0.5	-0.7	-0.3	-0.9
Number of operations (self-reported)	0.2	0.4	0.8	0.2	0.5	0.5	0.2	0.8	-0.1	0.4	0.9	0.6	0.7	0.9
Average weekly beer plus cider intake	0.2	0.3	0.8	0.7	0.9	0.2	-0.5	0.3	0.1	0.6	-0.4	0.3	0.1	0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.7	-0.6	-0.4	-0.6	-1.3	-1.0	-0.8	-0.6	-0.8	-0.4	-0.9	-0.1
Myopia	0.2	0.2	1.0	-1.0	-0.5	-0.4	-0.4	-0.8	-0.3	-0.2	0.0	0.1	-0.2	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	1.9	0.4	-0.2	-0.3	-0.1	-0.1	1.4	-0.2	-0.1	-0.1	-0.3	-0.4
Leg fat mass (left)	0.2	0.9	4.9	-0.1	-0.9	-0.5	1.0	-0.1	2.2	-0.6	0.2	-0.8	-0.6	-1.3
Blood Platelet Count	0.1	1.4	4.5	0.2	-0.7	-0.7	0.4	-0.1	0.7	-0.9	-1.5	-1.4	-2.0	-2.1
Systolic Blood Pressure	0.1	0.3	1.9	0.4	1.4	0.5	0.2	0.4	-0.5	-0.1	0.3	0.4	0.6	0.6
Tanning	0.1	1.1	7.1	-0.5	-0.3	0.5	-1.0	0.0	-2.7	0.8	0.6	0.8	0.2	1.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.7	0.3	-0.1	0.4	0.4	0.8	-0.3	-0.0	0.1	-0.3	0.0	-0.3
Taking other prescription medications	0.1	0.1	0.9	-0.1	0.0	0.2	0.1	0.3	-1.0	0.1	0.3	-0.0	-0.1	0.0
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.2	0.2	0.3	-0.6	0.0	-0.2	-0.1	-0.5	-0.6	-0.6	-0.3
Had menopause	0.1	0.1	0.3	0.4	0.1	0.4	-0.0	0.6	-0.3	0.1	0.1	-0.1	0.0	0.1
Medication: Simvastatin	0.1	0.1	0.5	0.2	0.7	-0.1	-0.6	-0.1	-0.6	0.2	-0.3	-0.1	-0.3	0.2
Time employed in main current job	0.1	0.1	0.2	-0.2	-0.2	0.2	0.3	0.0	0.3	-0.1	0.4	0.2	0.4	-0.1
Father’s age at death	0.1	0.1	0.5	0.3	0.5	-0.2	-0.2	0.1	0.5	-0.0	-0.2	-0.6	-0.7	-0.1
Pulse rate	0.1	0.2	1.1	0.1	0.2	0.4	1.0	0.4	-0.3	-0.2	0.6	0.3	0.6	-0.2
Happiness	0.1	0.2	1.3	0.1	0.4	-0.0	0.4	-0.2	1.1	-0.1	0.1	0.3	0.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.2	-0.6	0.2	0.9	0.1	-0.3	-0.0	0.5	0.2	0.4	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.5	0.0	0.4	0.6	0.8	0.3	0.0	0.6	0.3	-0.0	-0.1
Medication: Allopurinol	0.1	0.2	0.4	-0.1	-0.4	-0.4	0.3	-0.1	0.6	-0.0	-0.5	-0.4	-0.6	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	0.1	-0.2	0.4	-0.7	0.3	-0.7	0.7	-0.1	0.1	-0.2	0.3
Back pain experienced in last month	0.1	0.1	1.4	0.1	-0.1	0.1	-0.0	0.2	-1.2	0.1	0.0	0.1	0.3	0.2
Pain experienced in last month	0.1	0.2	0.8	-0.1	-0.0	-0.3	0.5	0.1	0.4	-0.5	-0.5	-0.5	-0.2	-0.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	1.3	0.2	0.4	0.6	0.7	0.5	-1.1	0.2	0.8	0.6	0.0	0.3
Hair Pigment	0.0	0.2	0.5	0.3	-0.0	0.3	0.1	0.1	0.7	0.5	0.4	0.6	0.7	0.3
Illnesses of mother	0.0	0.1	0.4	0.2	-0.0	0.2	0.0	0.6	-0.0	-0.0	-0.1	-0.2	-0.2	-0.2
Mood swings	0.0	0.0	0.1	0.2	-0.1	-0.1	0.0	-0.3	0.2	-0.1	0.0	-0.2	-0.2	-0.4

Hub : Genes

MST1P9

Models

Trait associations